DT-Web

DB02821 - Canaline


Identification
Name Canaline
Accession Number DB02821 (EXPT00828)
Type small molecule
Description Not Available
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 134.1338
Groups experimental
Monoisotopic Weight 134.069142196
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Ornithine aminotransferase, mitochondrial
Name Ornithine aminotransferase, mitochondrial
Gene Name OAT
Pharmacological action unknown
Actions inhibitor
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score 0.6494

Predictions


Id Partner name Gene Name Score
2842 Glutamate-1-semialdehyde 2,1-aminomutase hemL 0.2082
3981 Ornithine decarboxylase antizyme 3 OAZ3 0.0307
3980 Ornithine decarboxylase antizyme 2 OAZ2 0.0307
410 Ornithine decarboxylase antizyme OAZ1 0.0307
285 Mitochondrial ornithine transporter 2 SLC25A2 0.0307
224 Mitochondrial ornithine transporter 1 SLC25A15 0.0307
619 Low-affinity cationic amino acid transporter 2 SLC7A2 0.0261
834 Arginase-2, mitochondrial ARG2 0.0248
336 Ornithine carbamoyltransferase, mitochondrial OTC 0.0239
235 High-affinity cationic amino acid transporter 1 SLC7A1 0.0237
150 Cationic amino acid transporter 3 SLC7A3 0.0237
58 Cationic amino acid transporter 4 SLC7A4 0.0237
383 Glycine amidinotransferase, mitochondrial GATM 0.023
315 Arginase-1 ARG1 0.0202
3883 Ornithine aminotransferase variant Not Available 0.0066
3908 P-selectin cytoplasmic tail-associated protein pcap 0.0055
3915 Cysteine sulfinic acid decarboxylase-related protein 1 CSAD 0.0055
306 Pyridoxal phosphate phosphatase PDXP 0.0055
3911 Uncharacterized protein C20orf38 SPTLC3 0.0055
3906 Serine dehydratase-like SDSL 0.0055
3896 CDNA FLJ46802 fis, clone TRACH3032150, moderately similar to Cysteine sulfinic acid decarboxylase GADL1 0.0055
3891 Putative L-Dopa decarboxylase DDC 0.0055
3909 Hepatic peroxysomal alanine:glyoxylate aminotransferase Not Available 0.0055
3881 Selenocysteine lyase variant Not Available 0.0055
3878 GAD1 protein GAD1 0.0055
3887 Phosphorylase PYGB 0.0055
3914 Alanine-glyoxylate aminotransferase homolog TLH6 0.0055
3893 DDC protein DDC 0.0055
3880 Serine hydroxymethyltransferase 1 Not Available 0.0055
3910 O-phosphoseryl-tRNA(Sec) selenium transferase SEPSECS 0.0055
3875 Glycogen phosphorylase, brain form PYGB 0.0055
3882 Brain glycogen phosphorylase variant Not Available 0.0055
855 Sphingosine-1-phosphate lyase 1 SGPL1 0.0055
3905 Molybdenum cofactor sulfurase MOCOS 0.0055
3903 Aminolevulinate, delta-, synthase 2 ALAS2 0.0055
664 Glutamate decarboxylase 2 GAD2 0.0055
3890 Glutamate decarboxylase 2 GAD2 0.0055
3886 Migration-inducing protein 4 ALAS1 0.0055
3894 KIAA0251 protein PDXDC1 0.0055
534 Threonine synthase-like 1 THNSL1 0.0049
3899 Alanine--glyoxylate aminotransferase 2-like 2 AGXT2L2 0.0049
3874 Proline synthetase co-transcribed bacterial homolog protein PROSC 0.0049
499 Arginine decarboxylase ADC 0.0048
431 Serine racemase SRR 0.0048
184 L-serine dehydratase SDS 0.0048
491 Serine palmitoyltransferase 1 SPTLC1 0.0048
89 Cysteine sulfinic acid decarboxylase CSAD 0.0048
727 Serine palmitoyltransferase 2 SPTLC2 0.0048
665 Phosphoserine aminotransferase PSAT1 0.0048
4652 Phosphoserine aminotransferase serC 0.0048
801 Kynurenine/alpha-aminoadipate aminotransferase mitochondrial AADAT 0.0048
3895 Kynurenine--oxoglutarate transaminase 3 CCBL2 0.0048
420 Glutamate decarboxylase 1 GAD1 0.0048
3900 Glutamate decarboxylase 1 GAD1 0.0048
575 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial GCAT 0.0048
455 5-aminolevulinate synthase, nonspecific, mitochondrial ALAS1 0.0048
681 Glycine dehydrogenase [decarboxylating], mitochondrial GLDC 0.0048
3 Histidine decarboxylase HDC 0.0047
435 Kynureninase KYNU 0.0047
4654 Kynureninase kynU 0.0047
203 Pyridoxine-5'-phosphate oxidase PNPO 0.0047
3913 Glutamic acid decarboxylase GAD65 0.0047
169 Cysteine desulfurase, mitochondrial NFS1 0.0045
868 Cystathionine gamma-lyase CTH 0.0044
301 Kynurenine--oxoglutarate transaminase 1 CCBL1 0.0044
3877 Growth-inhibiting protein 18 GIG18 0.0044
426 Aspartate aminotransferase, mitochondrial GOT2 0.0044
3884 SHMT2 protein SHMT2 0.0043
3901 SHMT2 protein SHMT2 0.0043
3885 Hypothetical protein DKFZp686P09201 DKFZp686P09201 0.0043
3879 Serine hydroxymethyltransferase 2 Not Available 0.0043
321 Serine hydroxymethyltransferase, mitochondrial SHMT2 0.0043
358 Cystathionine beta-synthase CBS 0.0043
914 Formimidoyltransferase-cyclodeaminase FTCD 0.0043
763 Tyrosine aminotransferase TAT 0.0042
5493 Tyrosine aminotransferase Not Available 0.0042
735 Alanine aminotransferase 1 GPT 0.0042
3904 Alanine aminotransferase 2 GPT2 0.0042
449 Ornithine decarboxylase ODC1 0.0042
795 Branched-chain-amino-acid aminotransferase, mitochondrial BCAT2 0.0041
114 Alanine--glyoxylate aminotransferase 2, mitochondrial AGXT2 0.0041
586 Aspartate aminotransferase, cytoplasmic GOT1 0.0041
349 Serine--pyruvate aminotransferase AGXT 0.0041
367 Serine hydroxymethyltransferase, cytosolic SHMT1 0.004
574 Branched-chain-amino-acid aminotransferase, cytosolic BCAT1 0.0038
10 Glycogen phosphorylase, liver form PYGL 0.0037
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0036
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0035
1152 Glycogen phosphorylase, muscle form PYGM 0.0029
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