DT-Web

DB02635 - N-[O-Phosphono-Pyridoxyl]-Isoleucine


Identification
Name N-[O-Phosphono-Pyridoxyl]-Isoleucine
Accession Number DB02635 (EXPT01863)
Type small molecule
Description Not Available
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 362.3154
Groups experimental
Monoisotopic Weight 362.124287612
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Branched-chain-amino-acid aminotransferase, mitochondrial
Name Branched-chain-amino-acid aminotransferase, mitochondrial
Gene Name BCAT2
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.3526

Predictions


Id Partner name Gene Name Score
574 Branched-chain-amino-acid aminotransferase, cytosolic BCAT1 0.0535
3184 3-methyl-2-oxobutanoate hydroxymethyltransferase panB 0.0406
3315 3-methyl-2-oxobutanoate hydroxymethyltransferase panB 0.0406
3179 2-isopropylmalate synthase leuA 0.0406
701 Isoleucine-tRNA synthetase IARS 0.038
4080 Isoleucyl-tRNA synthetase, mitochondrial IARS2 0.0379
546 Isoleucyl-tRNA synthetase, cytoplasmic IARS 0.0379
6151 Monocarboxylate transporter 10 SLC16A10 0.0367
501 Leucine carboxyl methyltransferase 1 LCMT1 0.033
3334 Deacetoxycephalosporin C synthetase cefE 0.0329
675 Leucine carboxyl methyltransferase 2 LCMT2 0.0329
846 Leucyl-tRNA synthetase, cytoplasmic LARS 0.0329
227 Probable leucyl-tRNA synthetase, mitochondrial LARS2 0.0329
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.032
2744 D-alanine aminotransferase dat 0.0291
2746 4-aminobutyrate aminotransferase gabT 0.0255
2749 UDP-4-amino-4-deoxy-L-arabinose--oxoglutarate aminotransferase arnB 0.0251
2842 Glutamate-1-semialdehyde 2,1-aminomutase hemL 0.0251
2249 Aspartate aminotransferase aspC 0.025
2671 Aspartate aminotransferase aspC 0.025
5490 Aspartate aminotransferase Not Available 0.025
489 Monocarboxylate transporter 2 SLC16A7 0.0246
500 Monocarboxylate transporter 4 SLC16A3 0.0246
2546 Histidinol-phosphate aminotransferase hisC 0.0235
2698 Histidinol-phosphate aminotransferase hisC 0.0235
301 Kynurenine--oxoglutarate transaminase 1 CCBL1 0.0225
738 Monocarboxylate transporter 1 SLC16A1 0.0217
199 Monocarboxylate transporter 8 SLC16A2 0.021
894 Alanine racemase alr 0.0195
2453 Alanine racemase alr 0.0195
3895 Kynurenine--oxoglutarate transaminase 3 CCBL2 0.0064
665 Phosphoserine aminotransferase PSAT1 0.0064
4652 Phosphoserine aminotransferase serC 0.0064
801 Kynurenine/alpha-aminoadipate aminotransferase mitochondrial AADAT 0.0064
420 Glutamate decarboxylase 1 GAD1 0.0064
3900 Glutamate decarboxylase 1 GAD1 0.0064
3877 Growth-inhibiting protein 18 GIG18 0.0058
426 Aspartate aminotransferase, mitochondrial GOT2 0.0056
914 Formimidoyltransferase-cyclodeaminase FTCD 0.0055
763 Tyrosine aminotransferase TAT 0.0054
5493 Tyrosine aminotransferase Not Available 0.0054
3904 Alanine aminotransferase 2 GPT2 0.0053
735 Alanine aminotransferase 1 GPT 0.0053
586 Aspartate aminotransferase, cytoplasmic GOT1 0.0053
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0047
4024 Mitochondrial glutamate carrier 2 SLC25A18 0.0037
4025 Mitochondrial glutamate carrier 1 SLC25A22 0.0037
664 Glutamate decarboxylase 2 GAD2 0.0037
3890 Glutamate decarboxylase 2 GAD2 0.0037
4026 Aspartyl aminopeptidase DNPEP 0.0037
4022 Glutamate--ammonia ligase domain-containing protein 1 LGSN 0.0037
4021 Probable glutamyl-tRNA synthetase, mitochondrial EARS2 0.0037
4023 N-acetylglutamate synthase, mitochondrial NAGS 0.0037
1912 Excitatory amino acid transporter 1 SLC1A3 0.0037
4016 Excitatory amino acid transporter 5 SLC1A7 0.0037
4019 Excitatory amino acid transporter 4 SLC1A6 0.0037
1047 Excitatory amino acid transporter 2 SLC1A2 0.0037
919 Glutamate receptor, ionotropic kainate 4 GRIK4 0.0037
926 Metabotropic glutamate receptor 7 GRM7 0.0037
915 Delta 1-pyrroline-5-carboxylate synthetase ALDH18A1 0.0037
922 Glutamate receptor 4 GRIA4 0.0037
927 Metabotropic glutamate receptor 8 GRM8 0.0037
925 Metabotropic glutamate receptor 4 GRM4 0.0037
924 Glutamate receptor, ionotropic kainate 3 GRIK3 0.0037
4020 Glutamyl aminopeptidase ENPEP 0.0037
920 Glutamate receptor, ionotropic kainate 5 GRIK5 0.0037
4017 5-oxoprolinase OPLAH 0.0037
4027 Glutamate receptor delta-1 subunit GRID1 0.0037
4018 Glutamate receptor delta-2 subunit GRID2 0.0037
306 Pyridoxal phosphate phosphatase PDXP 0.0036
3881 Selenocysteine lyase variant Not Available 0.0036
3887 Phosphorylase PYGB 0.0036
3908 P-selectin cytoplasmic tail-associated protein pcap 0.0036
3915 Cysteine sulfinic acid decarboxylase-related protein 1 CSAD 0.0036
3914 Alanine-glyoxylate aminotransferase homolog TLH6 0.0036
3911 Uncharacterized protein C20orf38 SPTLC3 0.0036
3906 Serine dehydratase-like SDSL 0.0036
3896 CDNA FLJ46802 fis, clone TRACH3032150, moderately similar to Cysteine sulfinic acid decarboxylase GADL1 0.0036
3891 Putative L-Dopa decarboxylase DDC 0.0036
3909 Hepatic peroxysomal alanine:glyoxylate aminotransferase Not Available 0.0036
3878 GAD1 protein GAD1 0.0036
3893 DDC protein DDC 0.0036
3880 Serine hydroxymethyltransferase 1 Not Available 0.0036
3883 Ornithine aminotransferase variant Not Available 0.0036
3910 O-phosphoseryl-tRNA(Sec) selenium transferase SEPSECS 0.0036
855 Sphingosine-1-phosphate lyase 1 SGPL1 0.0036
3903 Aminolevulinate, delta-, synthase 2 ALAS2 0.0036
3886 Migration-inducing protein 4 ALAS1 0.0036
3894 KIAA0251 protein PDXDC1 0.0036
3875 Glycogen phosphorylase, brain form PYGB 0.0036
3882 Brain glycogen phosphorylase variant Not Available 0.0036
3905 Molybdenum cofactor sulfurase MOCOS 0.0036
625 Glutamate carboxypeptidase 2 FOLH1 0.0032
3984 Probable glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial PET112L 0.0032
355 GMP synthase [glutamine-hydrolyzing] GMPS 0.0032
4353 GMP synthase [glutamine-hydrolyzing] guaA 0.0032
668 Glutamate--cysteine ligase regulatory subunit GCLM 0.0032
5 Glutaminase liver isoform, mitochondrial GLS2 0.0032
917 Glutaminase kidney isoform, mitochondrial GLS 0.0032
3991 Glutamine-dependent NAD(+) synthetase NADSYN1 0.0032
3982 Phosphoribosylformylglycinamidine synthase PFAS 0.0032
5261 Phosphoribosylformylglycinamidine synthase purL 0.0032
830 Glutamate dehydrogenase 2, mitochondrial GLUD2 0.0032
3874 Proline synthetase co-transcribed bacterial homolog protein PROSC 0.0031
534 Threonine synthase-like 1 THNSL1 0.0031
3899 Alanine--glyoxylate aminotransferase 2-like 2 AGXT2L2 0.0031
184 L-serine dehydratase SDS 0.0031
727 Serine palmitoyltransferase 2 SPTLC2 0.0031
431 Serine racemase SRR 0.0031
491 Serine palmitoyltransferase 1 SPTLC1 0.0031
89 Cysteine sulfinic acid decarboxylase CSAD 0.0031
499 Arginine decarboxylase ADC 0.0031
575 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial GCAT 0.0031
455 5-aminolevulinate synthase, nonspecific, mitochondrial ALAS1 0.0031
681 Glycine dehydrogenase [decarboxylating], mitochondrial GLDC 0.0031
3 Histidine decarboxylase HDC 0.0031
435 Kynureninase KYNU 0.003
4654 Kynureninase kynU 0.003
472 Ornithine aminotransferase, mitochondrial OAT 0.0029
3913 Glutamic acid decarboxylase GAD65 0.0029
916 Metabotropic glutamate receptor 1 GRM1 0.0029
203 Pyridoxine-5'-phosphate oxidase PNPO 0.0029
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0029
169 Cysteine desulfurase, mitochondrial NFS1 0.0029
923 Glutamate receptor 3 GRIA3 0.0028
1671 Excitatory amino acid transporter 3 SLC1A1 0.0028
83 Alpha-aminoadipic semialdehyde synthase, mitochondrial AASS 0.0028
186 Glutamate--cysteine ligase catalytic subunit GCLC 0.0028
868 Cystathionine gamma-lyase CTH 0.0028
201 Glutamate dehydrogenase 1, mitochondrial GLUD1 0.0028
210 Bifunctional aminoacyl-tRNA synthetase [Includes: Glutamyl-tRNA synthetase EPRS 0.0028
3884 SHMT2 protein SHMT2 0.0027
3901 SHMT2 protein SHMT2 0.0027
3885 Hypothetical protein DKFZp686P09201 DKFZp686P09201 0.0027
3879 Serine hydroxymethyltransferase 2 Not Available 0.0027
321 Serine hydroxymethyltransferase, mitochondrial SHMT2 0.0027
448 Vitamin K-dependent gamma-carboxylase GGCX 0.0027
358 Cystathionine beta-synthase CBS 0.0027
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0027
114 Alanine--glyoxylate aminotransferase 2, mitochondrial AGXT2 0.0026
349 Serine--pyruvate aminotransferase AGXT 0.0026
449 Ornithine decarboxylase ODC1 0.0026
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0025
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0025
242 Asparagine synthetase [glutamine-hydrolyzing] ASNS 0.0025
367 Serine hydroxymethyltransferase, cytosolic SHMT1 0.0025
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0025
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0024
33 Cystine/glutamate transporter SLC7A11 0.0024
3426 Glutamine synthetase glnA 0.0023
3987 Glutamine synthetase GLUL 0.0023
705 Glutamate receptor 1 GRIA1 0.0023
10 Glycogen phosphorylase, liver form PYGL 0.0023
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0022
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0022
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0022
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0018
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0018
1152 Glycogen phosphorylase, muscle form PYGM 0.0018
921 Glutamate receptor 2 GRIA2 0.0017
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