| Name |
D-alanine aminotransferase |
| Synonyms |
4707 |
| Gene name |
dat |
| General function |
Amino acid transport and metabolism |
| Specific function |
Acts on the D-isomers of alanine, leucine, aspartate, glutamate, aminobutyrate, norvaline and asparagine. The enzyme transfers an amino group from a substrate D-amino acid to the pyridoxal phosphate cofactor to form pyridoxamine and an alpha- keto acid in the first half-reaction. The second-half reaction is the reverse of the first, transferring the amino group from the pyridoxamine to a second alpha-keto acid to form the product D- amino acid via a ping-pong mechanism. This is an important process in the formation of D-alanine and D-glutamate, which are essential bacterial cell wall components |
| Gene sequence |
+ ...
ATGGGATACACTTTATGGAATGACCAAATCGTGAAAGATGAAGAAGTCAAAATTGATAAAGAAGATCGCGGTTATCAATTCGGTGATGGCGTATATGAAGTTGTGAAAGTATATAACGGTGAAATGTTTACTGTAAATGAACATATTGACCGATTATATGCATCAGCTGAAAAAATACGAATTACGATTCCATATACAAAGGATAAATTTCATCAATTGCTACATGAATTAGTGGAAAAAAATGAATTAAACACTGGGCATATTTATTTTCAAGTTACTCGCGGAACTTCGCCTCGTGCGCATCAATTCCCTGAGAATACTGTAAAACCAGTAATCATCGGTTATACGAAAGAAAATCCACGACCATTAGAAAATCTTGAAAAAGGTGTAAAAGCTACCTTTGTGGAAGATATCCGTTGGTTACGATGTGATATTAAATCTTTGAACTTGCTTGGTGCAGTATTAGCAAAACAAGAAGCTCATGAAAAAGGCTGCTATGAAGCGATTCTACATCGAAATAATACAGTAACAGAAGGCTCTTCTTCAAATGTATTTGGAATAAAAGATGGTATATTGTATACCCATCCTGCAAACAATATGATTTTAAAAGGAATCACTCGCGACGTTGTCATAGCTTGTGCAAATGAAATTAATATGCCTGTAAAAGAAATTCCATTTACAACTCATGAAGCATTGAAAATGGATGAATTATTTGTAACAAGTACAACTTCTGAAATTACGCCGGTTATTGAAATAGATGGTAAGTTGATTCGAGATGGAAAAGTTGGAGAATGGACTCGTAAATTACAAAAACAATTTGAAACAAAAATTCCAAAACCGCTTCATATATAA
|
| Protein sequence |
+ ...
MGYTLWNDQIVKDEEVKIDKEDRGYQFGDGVYEVVKVYNGEMFTVNEHIDRLYASAEKIRITIPYTKDKFHQLLHELVEKNELNTGHIYFQVTRGTSPRAHQFPENTVKPVIIGYTKENPRPLENLEKGVKATFVEDIRWLRCDIKSLNLLGAVLAKQEAHEKGCYEAILHRNNTVTEGSSSNVFGIKDGILYTHPANNMILKGITRDVVIACANEINMPVKEIPFTTHEALKMDELFVTSTTSEITPVIEIDGKLIRDGKVGEWTRKLQKQFETKIPKPLHI
|
| GO Classification |
| function |
| catalytic activity |
| transferase activity |
| transferase activity, transferring nitrogenous groups |
| transaminase activity |
| process |
| physiological process |
| metabolism |
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