DT-Web

DB00142 - L-Glutamic Acid


Identification
Name L-Glutamic Acid
Accession Number DB00142 (NUTR00027)
Type small molecule
Description A peptide that is a homopolymer of glutamic acid. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 147.1293
Groups approved
Monoisotopic Weight 147.053157781
Pharmacology
Indication Considered to be nature's "Brain food" by improving mental capacities; helps speed the healing of ulcers; gives a "lift" from fatigue; helps control alcoholism, schizophrenia and the craving for sugar.
Mechanism of action Glutamate activates both ionotropic and metabotropic glutamate receptors. The ionotropic ones being non-NMDA (AMPA and kainate) and NMDA receptors. Free glutamic acid cannot cross the blood-brain barrier in appreciable quantities; instead it is converted into L-glutamine, which the brain uses for fuel and protein synthesis. It is conjectured that glutamate is involved in cognitive functions like learning and memory in the brain, though excessive amounts may cause neuronal damage associated in diseases like amyotrophic lateral sclerosis, lathyrism, and Alzheimer's disease. Also, the drug phencyclidine (more commonly known as PCP) antagonizes glutamate at the NMDA receptor, causing behavior reminiscent of schizophrenia. Glutamate in action is extremely difficult to study due to its transient nature.
Absorption Absorbed from the lumen of the small intestine into the enterocytes.Absorption is efficient and occurs by an active transport mechanism.
Protein binding Not Available
Biotransformation Hepatic
Route of elimination Not Available
Toxicity Glutamate causes neuronal damage and eventual cell death, particularly when NMDA receptors are activated, High dosages of glutamic acid may include symptoms such as headaches and neurological problems.
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Metabotropic glutamate receptor 1
Name Metabotropic glutamate receptor 1
Gene Name GRM1
Pharmacological action unknown
Actions Not Available
References
  • Suzuki G, Kimura T, Satow A, Kaneko N, Fukuda J, Hikichi H, Sakai N, Maehara S, Kawagoe-Takaki H, Hata M, Azuma T, Ito S, Kawamoto H, Ohta H: Pharmacological characterization of a new, orally active and potent allosteric metabotropic glutamate receptor 1 antagonist, 4-[1-(2-fluoropyridin-3-yl)-5-methyl-1H-1,2,3-triazol-4-yl]-N-isopropyl-N- methyl-3,6-dihydropyridine-1(2H)-carboxamide (FTIDC). J Pharmacol Exp Ther. 2007 Jun;321(3):1144-53. Epub 2007 Mar 14. - Pubmed
  • Chiocchetti A, Miglio G, Mesturini R, Varsaldi F, Mocellin M, Orilieri E, Dianzani C, Fantozzi R, Dianzani U, Lombardi G: Group I mGlu receptor stimulation inhibits activation-induced cell death of human T lymphocytes. Br J Pharmacol. 2006 Jul;148(6):760-8. Epub 2006 Jun 5. - Pubmed
  • San Gabriel AM, Maekawa T, Uneyama H, Yoshie S, Torii K: mGluR1 in the fundic glands of rat stomach. FEBS Lett. 2007 Mar 20;581(6):1119-23. Epub 2007 Feb 22. - Pubmed
DTHybrid score 1.2117
Metabotropic glutamate receptor 4
Name Metabotropic glutamate receptor 4
Gene Name GRM4
Pharmacological action unknown
Actions Not Available
References
  • Suzuki G, Kimura T, Satow A, Kaneko N, Fukuda J, Hikichi H, Sakai N, Maehara S, Kawagoe-Takaki H, Hata M, Azuma T, Ito S, Kawamoto H, Ohta H: Pharmacological characterization of a new, orally active and potent allosteric metabotropic glutamate receptor 1 antagonist, 4-[1-(2-fluoropyridin-3-yl)-5-methyl-1H-1,2,3-triazol-4-yl]-N-isopropyl-N- methyl-3,6-dihydropyridine-1(2H)-carboxamide (FTIDC). J Pharmacol Exp Ther. 2007 Jun;321(3):1144-53. Epub 2007 Mar 14. - Pubmed
DTHybrid score 0.8721
Glutamate receptor, ionotropic kainate 4
Name Glutamate receptor, ionotropic kainate 4
Gene Name GRIK4
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Korczak B, Nutt SL, Fletcher EJ, Hoo KH, Elliott CE, Rampersad V, McWhinnie EA, Kamboj RK: cDNA cloning and functional properties of human glutamate receptor EAA3 (GluR5) in homomeric and heteromeric configuration. Receptors Channels. 1995;3(1):41-9. - Pubmed
DTHybrid score 0.871
Glutamate receptor, ionotropic kainate 5
Name Glutamate receptor, ionotropic kainate 5
Gene Name GRIK5
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Takeda M, Haga M, Yamada H, Kinoshita M, Otsuka M, Tsuboi S, Moriyama Y: Ionotropic glutamate receptors expressed in human retinoblastoma Y79 cells. Neurosci Lett. 2000 Nov 17;294(2):97-100. - Pubmed
  • Murphy DE, Hutchison AJ, Hurt SD, Williams M, Sills MA: Characterization of the binding of [3H]-CGS 19755: a novel N-methyl-D-aspartate antagonist with nanomolar affinity in rat brain. Br J Pharmacol. 1988 Nov;95(3):932-8. - Pubmed
DTHybrid score 0.871
Metabotropic glutamate receptor 7
Name Metabotropic glutamate receptor 7
Gene Name GRM7
Pharmacological action unknown
Actions Not Available
References
  • Suzuki G, Kimura T, Satow A, Kaneko N, Fukuda J, Hikichi H, Sakai N, Maehara S, Kawagoe-Takaki H, Hata M, Azuma T, Ito S, Kawamoto H, Ohta H: Pharmacological characterization of a new, orally active and potent allosteric metabotropic glutamate receptor 1 antagonist, 4-[1-(2-fluoropyridin-3-yl)-5-methyl-1H-1,2,3-triazol-4-yl]-N-isopropyl-N- methyl-3,6-dihydropyridine-1(2H)-carboxamide (FTIDC). J Pharmacol Exp Ther. 2007 Jun;321(3):1144-53. Epub 2007 Mar 14. - Pubmed
DTHybrid score 0.872
Metabotropic glutamate receptor 8
Name Metabotropic glutamate receptor 8
Gene Name GRM8
Pharmacological action unknown
Actions Not Available
References
  • Suzuki G, Kimura T, Satow A, Kaneko N, Fukuda J, Hikichi H, Sakai N, Maehara S, Kawagoe-Takaki H, Hata M, Azuma T, Ito S, Kawamoto H, Ohta H: Pharmacological characterization of a new, orally active and potent allosteric metabotropic glutamate receptor 1 antagonist, 4-[1-(2-fluoropyridin-3-yl)-5-methyl-1H-1,2,3-triazol-4-yl]-N-isopropyl-N- methyl-3,6-dihydropyridine-1(2H)-carboxamide (FTIDC). J Pharmacol Exp Ther. 2007 Jun;321(3):1144-53. Epub 2007 Mar 14. - Pubmed
  • Morimoto R, Uehara S, Yatsushiro S, Juge N, Hua Z, Senoh S, Echigo N, Hayashi M, Mizoguchi T, Ninomiya T, Udagawa N, Omote H, Yamamoto A, Edwards RH, Moriyama Y: Secretion of L-glutamate from osteoclasts through transcytosis. EMBO J. 2006 Sep 20;25(18):4175-86. Epub 2006 Sep 7. - Pubmed
DTHybrid score 0.8726
Excitatory amino acid transporter 5
Name Excitatory amino acid transporter 5
Gene Name SLC1A7
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Takarada T, Hinoi E, Balcar VJ, Taniura H, Yoneda Y: Possible expression of functional glutamate transporters in the rat testis. J Endocrinol. 2004 May;181(2):233-44. - Pubmed
  • Arriza JL, Eliasof S, Kavanaugh MP, Amara SG: Excitatory amino acid transporter 5, a retinal glutamate transporter coupled to a chloride conductance. Proc Natl Acad Sci U S A. 1997 Apr 15;94(8):4155-60. - Pubmed
DTHybrid score 0.871
5-oxoprolinase
Name 5-oxoprolinase
Gene Name OPLAH
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Nishimura A, Itoh H, Oyama H, Murao S, Oda K: A simultaneous assay method for L-glutamate and L-pyroglutamate contents in soy sauce using a 5-oxoprolinase (without ATP hydrolyzing activity). Biosci Biotechnol Biochem. 2001 Feb;65(2):477-9. - Pubmed
  • Van der Werf P, Stephani RA, Orlowski M, Meister A: Inhibition of 5-oxoprolinase by 2-imidazolidone-4-carboxylic acid. Proc Natl Acad Sci U S A. 1973 Mar;70(3):759-61. - Pubmed
  • Seddon AP, Li LY, Meister A: Resolution of 5-oxo-L-prolinase into a 5-oxo-L-proline-dependent ATPase and a coupling protein. J Biol Chem. 1984 Jul 10;259(13):8091-4. - Pubmed
DTHybrid score 0.8689
Phosphoribosylformylglycinamidine synthase
Name Phosphoribosylformylglycinamidine synthase
Gene Name PFAS
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Jayaram HN, Lui MS, Plowman J, Pillwein K, Reardon MA, Elliott WL, Weber G: Oncolytic activity and mechanism of action of a novel L-cysteine derivative, L-cysteine, ethyl ester, S-(N-methylcarbamate) monohydrochloride. Cancer Chemother Pharmacol. 1990;26(2):88-92. - Pubmed
DTHybrid score 0.9011
Branched-chain-amino-acid aminotransferase, mitochondrial
Name Branched-chain-amino-acid aminotransferase, mitochondrial
Gene Name BCAT2
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.9435
Glutamate [NMDA] receptor subunit epsilon-4
Name Glutamate [NMDA] receptor subunit epsilon-4
Gene Name GRIN2D
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Pliss L, Jezova D, Mares V, Balcar VJ, St'astny F: N-Acetyl-L-aspartyl-L-glutamate changes functional and structural properties of rat blood-brain barrier. Neurosci Lett. 2002 Jan 11;317(2):85-8. - Pubmed
  • Bresink I, Benke TA, Collett VJ, Seal AJ, Parsons CG, Henley JM, Collingridge GL: Effects of memantine on recombinant rat NMDA receptors expressed in HEK 293 cells. Br J Pharmacol. 1996 Sep;119(2):195-204. - Pubmed
  • Sundstrom E, Whittemore S, Mo LL, Seiger A: Analysis of NMDA receptors in the human spinal cord. Exp Neurol. 1997 Dec;148(2):407-13. - Pubmed
DTHybrid score 0.8875
Glutamate receptor delta-2 subunit
Name Glutamate receptor delta-2 subunit
Gene Name GRID2
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.8694
Glutamate [NMDA] receptor subunit 3B
Name Glutamate [NMDA] receptor subunit 3B
Gene Name GRIN3B
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.7797
Probable glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial
Name Probable glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial
Gene Name PET112L
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.9014
Glutaminase kidney isoform, mitochondrial
Name Glutaminase kidney isoform, mitochondrial
Gene Name GLS
Pharmacological action unknown
Actions Not Available
References
  • Karmaker S, Saha TK, Yoshikawa Y, Yasui H, Sakurai H: A novel drug delivery system for type 1 diabetes: insulin-mimetic vanadyl-poly(gamma-glutamic acid) complex. J Inorg Biochem. 2006 Sep;100(9):1535-46. Epub 2006 May 24. - Pubmed
  • Shi F, Xu Z, Cen P: Efficient production of poly-gamma-glutamic acid by Bacillus subtilis ZJU-7. Appl Biochem Biotechnol. 2006 Jun;133(3):271-82. - Pubmed
  • Yang XX, Hu ZP, Xu AL, Duan W, Zhu YZ, Huang M, Sheu FS, Zhang Q, Bian JS, Chan E, Li X, Wang JC, Zhou SF: A mechanistic study on reduced toxicity of irinotecan by coadministered thalidomide, a tumor necrosis factor-alpha inhibitor. J Pharmacol Exp Ther. 2006 Oct;319(1):82-104. Epub 2006 Jun 30. - Pubmed
  • Ashiuchi M, Shimanouchi K, Horiuchi T, Kamei T, Misono H: Genetically engineered poly-gamma-glutamate producer from Bacillus subtilis ISW1214. Biosci Biotechnol Biochem. 2006 Jul;70(7):1794-7. - Pubmed
  • Ashiuchi M, Nakamura H, Yamamoto M, Misono H: Novel poly-gamma-glutamate-processing enzyme catalyzing gamma-glutamyl DD-amidohydrolysis. J Biosci Bioeng. 2006 Jul;102(1):60-5. - Pubmed
DTHybrid score 0.904
Aspartate aminotransferase, mitochondrial
Name Aspartate aminotransferase, mitochondrial
Gene Name GOT2
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Recasens M, Mandel P: Similarities between cysteinesulphinate transaminase and aspartate aminotransferase. Ciba Found Symp. 1979;(72):259-70. - Pubmed
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 0.8684
Bifunctional aminoacyl-tRNA synthetase [Includes: Glutamyl-tRNA synthetase
Name Bifunctional aminoacyl-tRNA synthetase [Includes: Glutamyl-tRNA synthetase
Gene Name EPRS
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Cerini C, Semeriva M, Gratecos D: Evolution of the aminoacyl-tRNA synthetase family and the organization of the Drosophila glutamyl-prolyl-tRNA synthetase gene. Intron/exon structure of the gene, control of expression of the two mRNAs, selective advantage of the multienzyme complex. Eur J Biochem. 1997 Feb 15;244(1):176-85. - Pubmed
  • Ting SM, Dignam JD: Post-transcriptional regulation of glutamyl-prolyl-tRNA synthetase in rat salivary gland. J Biol Chem. 1994 Mar 25;269(12):8993-8. - Pubmed
DTHybrid score 1.4954
Asparagine synthetase [glutamine-hydrolyzing]
Name Asparagine synthetase [glutamine-hydrolyzing]
Gene Name ASNS
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.7959
Glutamine synthetase
Name Glutamine synthetase
Gene Name GLUL
Pharmacological action unknown
Actions Not Available
References
  • Re DB, Nafia I, Melon C, Shimamoto K, Kerkerian-Le Goff L, Had-Aissouni L: Glutamate leakage from a compartmentalized intracellular metabolic pool and activation of the lipoxygenase pathway mediate oxidative astrocyte death by reversed glutamate transport. Glia. 2006 Jul;54(1):47-57. - Pubmed
  • Singh U, Sarkar D: Development of a simple high-throughput screening protocol based on biosynthetic activity of Mycobacterium tuberculosis glutamine synthetase for the identification of novel Inhibitors. J Biomol Screen. 2006 Dec;11(8):1035-42. Epub 2006 Sep 14. - Pubmed
  • Yamamoto S, Wakayama M, Tachiki T: Characterization of theanine-forming enzyme from Methylovorus mays no. 9 in respect to utilization of theanine production. Biosci Biotechnol Biochem. 2007 Feb;71(2):545-52. Epub 2007 Feb 7. - Pubmed
  • Scaraffia PY, Zhang Q, Wysocki VH, Isoe J, Wells MA: Analysis of whole body ammonia metabolism in Aedes aegypti using [15N]-labeled compounds and mass spectrometry. Insect Biochem Mol Biol. 2006 Aug;36(8):614-22. Epub 2006 May 19. - Pubmed
DTHybrid score 0.003
Aspartate aminotransferase, cytoplasmic
Name Aspartate aminotransferase, cytoplasmic
Gene Name GOT1
Pharmacological action unknown
Actions Not Available
References
  • Yudkoff M, Daikhin Y, Melo TM, Nissim I, Sonnewald U, Nissim I: The Ketogenic Diet and Brain Metabolism of Amino Acids: Relationship to the Anticonvulsant Effect. Annu Rev Nutr. 2007 Aug 21;27:415-430. - Pubmed
DTHybrid score 0.7952
Tyrosine aminotransferase
Name Tyrosine aminotransferase
Gene Name TAT
Pharmacological action unknown
Actions Not Available
References
  • Ozturk M, Chiu CY, Akdeniz N, Jenq SF, Chang SC, Hsa CY, Jap TS: Two novel mutations in the MEN1 gene in subjects with multiple endocrine neoplasia-1. J Endocrinol Invest. 2006 Jun;29(6):523-7. - Pubmed
DTHybrid score 0.7354
Alanine aminotransferase 1
Name Alanine aminotransferase 1
Gene Name GPT
Pharmacological action unknown
Actions Not Available
References
  • Ohgami N, Upadhyay S, Kabata A, Morimoto K, Kusakabe H, Suzuki H: Determination of the activities of glutamic oxaloacetic transaminase and glutamic pyruvic transaminase in a microfluidic system. Biosens Bioelectron. 2007 Feb 15;22(7):1330-6. Epub 2006 Jul 18. - Pubmed
DTHybrid score 0.7255
Vitamin K-dependent gamma-carboxylase
Name Vitamin K-dependent gamma-carboxylase
Gene Name GGCX
Pharmacological action unknown
Actions Not Available
References
  • Zhu A, Sun H, Raymond RM Jr, Furie BC, Furie B, Bronstein M, Kaufman RJ, Westrick R, Ginsburg D: Fatal hemorrhage in mice lacking gamma-glutamyl carboxylase. Blood. 2007 Jun 15;109(12):5270-5. Epub 2007 Feb 27. - Pubmed
  • Lal S, Jada SR, Xiang X, Lim WT, Lee EJ, Chowbay B: Pharmacogenetics of target genes across the warfarin pharmacological pathway. Clin Pharmacokinet. 2006;45(12):1189-200. - Pubmed
DTHybrid score 1.0418
Excitatory amino acid transporter 1
Name Excitatory amino acid transporter 1
Gene Name SLC1A3
Pharmacological action unknown
Actions Not Available
References
  • Glowatzki E, Cheng N, Hiel H, Yi E, Tanaka K, Ellis-Davies GC, Rothstein JD, Bergles DE: The glutamate-aspartate transporter GLAST mediates glutamate uptake at inner hair cell afferent synapses in the mammalian cochlea. J Neurosci. 2006 Jul 19;26(29):7659-64. - Pubmed
  • Beart PM, O'Shea RD: Transporters for L-glutamate: an update on their molecular pharmacology and pathological involvement. Br J Pharmacol. 2007 Jan;150(1):5-17. Epub 2006 Nov 6. - Pubmed
  • Nickell J, Salvatore MF, Pomerleau F, Apparsundaram S, Gerhardt GA: Reduced plasma membrane surface expression of GLAST mediates decreased glutamate regulation in the aged striatum. Neurobiol Aging. 2007 Nov;28(11):1737-48. Epub 2006 Sep 7. - Pubmed
DTHybrid score 0.8719
Excitatory amino acid transporter 2
Name Excitatory amino acid transporter 2
Gene Name SLC1A2
Pharmacological action unknown
Actions Not Available
References
  • King N, Lin H, McGivan JD, Suleiman MS: Expression and activity of the glutamate transporter EAAT2 in cardiac hypertrophy: implications for ischaemia reperfusion injury. Pflugers Arch. 2006 Sep;452(6):674-82. Epub 2006 May 23. - Pubmed
  • Nickell J, Salvatore MF, Pomerleau F, Apparsundaram S, Gerhardt GA: Reduced plasma membrane surface expression of GLAST mediates decreased glutamate regulation in the aged striatum. Neurobiol Aging. 2007 Nov;28(11):1737-48. Epub 2006 Sep 7. - Pubmed
  • Beart PM, O'Shea RD: Transporters for L-glutamate: an update on their molecular pharmacology and pathological involvement. Br J Pharmacol. 2007 Jan;150(1):5-17. Epub 2006 Nov 6. - Pubmed
  • Glowatzki E, Cheng N, Hiel H, Yi E, Tanaka K, Ellis-Davies GC, Rothstein JD, Bergles DE: The glutamate-aspartate transporter GLAST mediates glutamate uptake at inner hair cell afferent synapses in the mammalian cochlea. J Neurosci. 2006 Jul 19;26(29):7659-64. - Pubmed
DTHybrid score 0.8704
Excitatory amino acid transporter 3
Name Excitatory amino acid transporter 3
Gene Name SLC1A1
Pharmacological action unknown
Actions Not Available
References
  • Menaker D, Bendahan A, Kanner BI: The substrate specificity of a neuronal glutamate transporter is determined by the nature of the coupling ion. J Neurochem. 2006 Oct;99(1):20-8. Epub 2006 Jul 11. - Pubmed
  • Yun JY, Park KS, Kim JH, Do SH, Zuo Z: Propofol reverses oxidative stress-attenuated glutamate transporter EAAT3 activity: evidence of protein kinase C involvement. Eur J Pharmacol. 2007 Jun 22;565(1-3):83-8. Epub 2007 Mar 3. - Pubmed
  • Tao Z, Grewer C: Cooperation of the conserved aspartate 439 and bound amino acid substrate is important for high-affinity Na+ binding to the glutamate transporter EAAC1. J Gen Physiol. 2007 Apr;129(4):331-44. - Pubmed
  • Nickell J, Salvatore MF, Pomerleau F, Apparsundaram S, Gerhardt GA: Reduced plasma membrane surface expression of GLAST mediates decreased glutamate regulation in the aged striatum. Neurobiol Aging. 2007 Nov;28(11):1737-48. Epub 2006 Sep 7. - Pubmed
DTHybrid score 0.9645
Glutamate--cysteine ligase catalytic subunit
Name Glutamate--cysteine ligase catalytic subunit
Gene Name GCLC
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.712
Excitatory amino acid transporter 4
Name Excitatory amino acid transporter 4
Gene Name SLC1A6
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Gegelashvili G, Schousboe A: High affinity glutamate transporters: regulation of expression and activity. Mol Pharmacol. 1997 Jul;52(1):6-15. - Pubmed
  • Lin CL, Tzingounis AV, Jin L, Furuta A, Kavanaugh MP, Rothstein JD: Molecular cloning and expression of the rat EAAT4 glutamate transporter subtype. Brain Res Mol Brain Res. 1998 Dec 10;63(1):174-9. - Pubmed
DTHybrid score 0.8717
Glutamate dehydrogenase 2, mitochondrial
Name Glutamate dehydrogenase 2, mitochondrial
Gene Name GLUD2
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.6545
GMP synthase [glutamine-hydrolyzing]
Name GMP synthase [glutamine-hydrolyzing]
Gene Name GMPS
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Ravasio S, Dossena L, Martin-Figueroa E, Florencio FJ, Mattevi A, Morandi P, Curti B, Vanoni MA: Properties of the recombinant ferredoxin-dependent glutamate synthase of Synechocystis PCC6803. Comparison with the Azospirillum brasilense NADPH-dependent enzyme and its isolated alpha subunit. Biochemistry. 2002 Jun 25;41(25):8120-33. - Pubmed
  • Myers RS, Amaro RE, Luthey-Schulten ZA, Davisson VJ: Reaction coupling through interdomain contacts in imidazole glycerol phosphate synthase. Biochemistry. 2005 Sep 13;44(36):11974-85. - Pubmed
  • Boehlein SK, Richards NG, Schuster SM: Glutamine-dependent nitrogen transfer in Escherichia coli asparagine synthetase B. Searching for the catalytic triad. J Biol Chem. 1994 Mar 11;269(10):7450-7. - Pubmed
DTHybrid score 0.9014
Branched-chain-amino-acid aminotransferase, cytosolic
Name Branched-chain-amino-acid aminotransferase, cytosolic
Gene Name BCAT1
Pharmacological action unknown
Actions Not Available
References
  • Smirnov SV, Samsonova NN, Novikova AE, Matrosov NG, Rushkevich NY, Kodera T, Ogawa J, Yamanaka H, Shimizu S: A novel strategy for enzymatic synthesis of 4-hydroxyisoleucine: identification of an enzyme possessing HMKP (4-hydroxy-3-methyl-2-keto-pentanoate) aldolase activity. FEMS Microbiol Lett. 2007 Aug;273(1):70-7. Epub 2007 Jun 6. - Pubmed
DTHybrid score 0.9906
4-aminobutyrate aminotransferase, mitochondrial
Name 4-aminobutyrate aminotransferase, mitochondrial
Gene Name ABAT
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Imai H, Okuno T, Wu JY, Lee TJ: GABAergic innervation in cerebral blood vessels: an immunohistochemical demonstration of L-glutamic acid decarboxylase and GABA transaminase. J Cereb Blood Flow Metab. 1991 Jan;11(1):129-34. - Pubmed
  • Happola O, Paivarinta H, Soinila S, Wu JY, Panula P: Localization of L-glutamate decarboxylase and GABA transaminase immunoreactivity in the sympathetic ganglia of the rat. Neuroscience. 1987 Apr;21(1):271-81. - Pubmed
  • Far SR, Millimoria FR: Levels of glutamic acid decarboxylase (GAD), gamma amino butyric acid transaminase (GABA-T), glutamic acid dehydrogenase (GLDH) and proteins in cerebrospinal fluid of certain neurological disorders. Indian J Med Sci. 1996 Apr;50(4):99-102. - Pubmed
DTHybrid score 1.0231
Glutamate [NMDA] receptor subunit zeta-1
Name Glutamate [NMDA] receptor subunit zeta-1
Gene Name GRIN1
Pharmacological action unknown
Actions Not Available
References
  • Miglio G, Dianzani C, Fallarini S, Fantozzi R, Lombardi G: Stimulation of N-methyl-D-aspartate receptors modulates Jurkat T cell growth and adhesion to fibronectin. Biochem Biophys Res Commun. 2007 Sep 21;361(2):404-9. Epub 2007 Jul 20. - Pubmed
DTHybrid score 1.1607
Folylpolyglutamate synthase, mitochondrial
Name Folylpolyglutamate synthase, mitochondrial
Gene Name FPGS
Pharmacological action unknown
Actions Not Available
References
  • DeMartino JK, Hwang I, Xu L, Wilson IA, Boger DL: Discovery of a potent, nonpolyglutamatable inhibitor of glycinamide ribonucleotide transformylase. J Med Chem. 2006 May 18;49(10):2998-3002. - Pubmed
  • Gangjee A, Yang J, McGuire JJ, Kisliuk RL: Synthesis and evaluation of a classical 2,4-diamino-5-substituted-furo[2,3-d]pyrimidine and a 2-amino-4-oxo-6-substituted-pyrrolo[2,3-d]pyrimidine as antifolates. Bioorg Med Chem. 2006 Dec 15;14(24):8590-8. Epub 2006 Sep 20. - Pubmed
DTHybrid score 0.8897
Glutamyl aminopeptidase
Name Glutamyl aminopeptidase
Gene Name ENPEP
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Tobe H, Kojima F, Aoyagi T, Umezawa H: Purification by affinity chromatography using amastatin and properties of aminopeptidase A from pig kidney. Biochim Biophys Acta. 1980 Jun 13;613(2):459-68. - Pubmed
  • Acarturk F, Parlatan ZI, Saracoglu OF: Comparison of vaginal aminopeptidase enzymatic activities in various animals and in humans. J Pharm Pharmacol. 2001 Nov;53(11):1499-504. - Pubmed
  • Sasaki M, Bosman BW, Tan PS: Comparison of proteolytic activities in various lactobacilli. J Dairy Res. 1995 Nov;62(4):601-10. - Pubmed
DTHybrid score 0.869
Glutamate [NMDA] receptor subunit epsilon-1
Name Glutamate [NMDA] receptor subunit epsilon-1
Gene Name GRIN2A
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Rutter AR, Freeman FM, Stephenson FA: Further characterization of the molecular interaction between PSD-95 and NMDA receptors: the effect of the NR1 splice variant and evidence for modulation of channel gating. J Neurochem. 2002 Jun;81(6):1298-307. - Pubmed
  • Rutter AR, Stephenson FA: Coexpression of postsynaptic density-95 protein with NMDA receptors results in enhanced receptor expression together with a decreased sensitivity to L-glutamate. J Neurochem. 2000 Dec;75(6):2501-10. - Pubmed
  • Bresink I, Benke TA, Collett VJ, Seal AJ, Parsons CG, Henley JM, Collingridge GL: Effects of memantine on recombinant rat NMDA receptors expressed in HEK 293 cells. Br J Pharmacol. 1996 Sep;119(2):195-204. - Pubmed
DTHybrid score 0.8623
Glutamate [NMDA] receptor subunit epsilon-2
Name Glutamate [NMDA] receptor subunit epsilon-2
Gene Name GRIN2B
Pharmacological action unknown
Actions Not Available
References
  • Verkhratsky A, Kirchhoff F: NMDA Receptors in glia. Neuroscientist. 2007 Feb;13(1):28-37. - Pubmed
  • Miglio G, Dianzani C, Fallarini S, Fantozzi R, Lombardi G: Stimulation of N-methyl-D-aspartate receptors modulates Jurkat T cell growth and adhesion to fibronectin. Biochem Biophys Res Commun. 2007 Sep 21;361(2):404-9. Epub 2007 Jul 20. - Pubmed
DTHybrid score 0.8707
Glutamate [NMDA] receptor subunit epsilon-3
Name Glutamate [NMDA] receptor subunit epsilon-3
Gene Name GRIN2C
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Kuner T, Schoepfer R, Korpi ER: Ethanol inhibits glutamate-induced currents in heteromeric NMDA receptor subtypes. Neuroreport. 1993 Dec 13;5(3):297-300. - Pubmed
  • Olmos G, DeGregorio-Rocasolano N, Paz Regalado M, Gasull T, Assumpcio Boronat M, Trullas R, Villarroel A, Lerma J, Garcia-Sevilla JA: Protection by imidazol(ine) drugs and agmatine of glutamate-induced neurotoxicity in cultured cerebellar granule cells through blockade of NMDA receptor. Br J Pharmacol. 1999 Jul;127(6):1317-26. - Pubmed
  • Sundstrom E, Whittemore S, Mo LL, Seiger A: Analysis of NMDA receptors in the human spinal cord. Exp Neurol. 1997 Dec;148(2):407-13. - Pubmed
DTHybrid score 0.8412
Growth-inhibiting protein 18
Name Growth-inhibiting protein 18
Gene Name GIG18
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.7353
Probable glutamyl-tRNA synthetase, mitochondrial
Name Probable glutamyl-tRNA synthetase, mitochondrial
Gene Name EARS2
Pharmacological action unknown
Actions Not Available
References
  • Sekine S, Shichiri M, Bernier S, Chenevert R, Lapointe J, Yokoyama S: Structural bases of transfer RNA-dependent amino acid recognition and activation by glutamyl-tRNA synthetase. Structure. 2006 Dec;14(12):1791-9. - Pubmed
DTHybrid score 0.8693
Glutamate--ammonia ligase domain-containing protein 1
Name Glutamate--ammonia ligase domain-containing protein 1
Gene Name LGSN
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.8693
Glutamine-dependent NAD(+) synthetase
Name Glutamine-dependent NAD(+) synthetase
Gene Name NADSYN1
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.9014
Kynurenine--oxoglutarate transaminase 3
Name Kynurenine--oxoglutarate transaminase 3
Gene Name CCBL2
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.717
N-acetylglutamate synthase, mitochondrial
Name N-acetylglutamate synthase, mitochondrial
Gene Name NAGS
Pharmacological action unknown
Actions Not Available
References
  • Xu Y, Labedan B, Glansdorff N: Surprising arginine biosynthesis: a reappraisal of the enzymology and evolution of the pathway in microorganisms. Microbiol Mol Biol Rev. 2007 Mar;71(1):36-47. - Pubmed
DTHybrid score 0.8693
Kynurenine/alpha-aminoadipate aminotransferase mitochondrial
Name Kynurenine/alpha-aminoadipate aminotransferase mitochondrial
Gene Name AADAT
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Kocki T, Luchowski P, Luchowska E, Wielosz M, Turski WA, Urbanska EM: L-cysteine sulphinate, endogenous sulphur-containing amino acid, inhibits rat brain kynurenic acid production via selective interference with kynurenine aminotransferase II. Neurosci Lett. 2003 Jul 31;346(1-2):97-100. - Pubmed
DTHybrid score 0.717
Glutamate [NMDA] receptor subunit 3A
Name Glutamate [NMDA] receptor subunit 3A
Gene Name GRIN3A
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.854
Alanine aminotransferase 2
Name Alanine aminotransferase 2
Gene Name GPT2
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.7255
Mitochondrial glutamate carrier 2
Name Mitochondrial glutamate carrier 2
Gene Name SLC25A18
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.8702
Mitochondrial glutamate carrier 1
Name Mitochondrial glutamate carrier 1
Gene Name SLC25A22
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.8703
Alpha-aminoadipic semialdehyde synthase, mitochondrial
Name Alpha-aminoadipic semialdehyde synthase, mitochondrial
Gene Name AASS
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Gaziola SA, Teixeira CM, Lugli J, Sodek L, Azevedo RA: The enzymology of lysine catabolism in rice seeds--isolation, characterization, and regulatory properties of a lysine 2-oxoglutarate reductase/saccharopine dehydrogenase bifunctional polypeptide. Eur J Biochem. 1997 Jul 1;247(1):364-71. - Pubmed
  • Goncalves-Butruille M, Szajner P, Torigoi E, Leite A, Arruda P: Purification and Characterization of the Bifunctional Enzyme Lysine-Ketoglutarate Reductase-Saccharopine Dehydrogenase from Maize. Plant Physiol. 1996 Mar;110(3):765-771. - Pubmed
  • Noda C, Ichihara A: Purification and properties of L-lysine-alpha-ketoglutarate reductase from rat liver mitochondria. Biochim Biophys Acta. 1978 Aug 7;525(2):307-13. - Pubmed
DTHybrid score 1.0031
Glutaminase liver isoform, mitochondrial
Name Glutaminase liver isoform, mitochondrial
Gene Name GLS2
Pharmacological action unknown
Actions Not Available
References
  • Dossena L, Curti B, Vanoni MA: Activation and coupling of the glutaminase and synthase reaction of glutamate synthase is mediated by E1013 of the ferredoxin-dependent enzyme, belonging to loop 4 of the synthase domain. Biochemistry. 2007 Apr 17;46(15):4473-85. Epub 2007 Mar 21. - Pubmed
  • Kita K, Suzuki T, Ochi T: Down-regulation of glutaminase C in human hepatocarcinoma cell by diphenylarsinic acid, a degradation product of chemical warfare agents. Toxicol Appl Pharmacol. 2007 May 1;220(3):262-70. Epub 2007 Jan 24. - Pubmed
  • Yoshimune K, Shirakihara Y, Shiratori A, Wakayama M, Chantawannakul P, Moriguchi M: Crystal structure of a major fragment of the salt-tolerant glutaminase from Micrococcus luteus K-3. Biochem Biophys Res Commun. 2006 Aug 11;346(4):1118-24. Epub 2006 Jun 6. - Pubmed
DTHybrid score 0.904
Aspartyl aminopeptidase
Name Aspartyl aminopeptidase
Gene Name DNPEP
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Watanabe J, Tanaka H, Akagawa T, Mogi Y, Yamazaki T: Characterization of Aspergillus oryzae Aspartyl Aminopeptidase Expressed in Escherichia coli. Biosci Biotechnol Biochem. 2007 Oct 7;. - Pubmed
DTHybrid score 0.8693
Glutamate receptor delta-1 subunit
Name Glutamate receptor delta-1 subunit
Gene Name GRID1
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.8695
Cystine/glutamate transporter
Name Cystine/glutamate transporter
Gene Name SLC7A11
Pharmacological action unknown
Actions Not Available
References
  • Natale NR, Magnusson KR, Nelson JK: Can selective ligands for glutamate binding proteins be rationally designed? Curr Top Med Chem. 2006;6(8):823-47. - Pubmed
DTHybrid score 0.6742
Plasma glutamate carboxypeptidase
Name Plasma glutamate carboxypeptidase
Gene Name PGCP
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score Not Available
Phosphoserine aminotransferase
Name Phosphoserine aminotransferase
Gene Name PSAT1
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Hester G, Stark W, Moser M, Kallen J, Markovic-Housley Z, Jansonius JN: Crystal structure of phosphoserine aminotransferase from Escherichia coli at 2.3 A resolution: comparison of the unligated enzyme and a complex with alpha-methyl-l-glutamate. J Mol Biol. 1999 Feb 26;286(3):829-50. - Pubmed
  • Katsura Y, Shirouzu M, Yamaguchi H, Ishitani R, Nureki O, Kuramitsu S, Hayashi H, Yokoyama S: Crystal structure of a putative aspartate aminotransferase belonging to subgroup IV. Proteins. 2004 May 15;55(3):487-92. - Pubmed
DTHybrid score 0.717
Glutamate dehydrogenase 1, mitochondrial
Name Glutamate dehydrogenase 1, mitochondrial
Gene Name GLUD1
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Anagnou NP, Seuanez H, Modi W, O'Brien SJ, Papamatheakis J, Moschonas NK: Chromosomal mapping of two members of the human glutamate dehydrogenase (GLUD) gene family to chromosomes 10q22.3-q23 and Xq22-q23. Hum Hered. 1993 Nov-Dec;43(6):351-6. - Pubmed
DTHybrid score 0.6583
Glutamate receptor, ionotropic kainate 1
Name Glutamate receptor, ionotropic kainate 1
Gene Name GRIK1
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Sahara Y, Noro N, Iida Y, Soma K, Nakamura Y: Glutamate receptor subunits GluR5 and KA-2 are coexpressed in rat trigeminal ganglion neurons. J Neurosci. 1997 Sep 1;17(17):6611-20. - Pubmed
  • Valgeirsson J, Christensen JK, Kristensen AS, Pickering DS, Nielsen B, Fischer CH, Brauner-Osborne H, Nielsen EO, Krogsgaard-Larsen P, Madsen U: Synthesis and in vitro pharmacology at AMPA and kainate preferring glutamate receptors of 4-heteroarylmethylidene glutamate analogues. Bioorg Med Chem. 2003 Oct 1;11(20):4341-9. - Pubmed
  • Stensbol TB, Borre L, Johansen TN, Egebjerg J, Madsen U, Ebert B, Krogsgaard-Larsen P: Resolution, absolute stereochemistry and molecular pharmacology of the enantiomers of ATPA. Eur J Pharmacol. 1999 Sep 10;380(2-3):153-62. - Pubmed
DTHybrid score 0.7447
Glutamate receptor 1
Name Glutamate receptor 1
Gene Name GRIA1
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Stein E, Cox JA, Seeburg PH, Verdoorn TA: Complex pharmacological properties of recombinant alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate receptor subtypes. Mol Pharmacol. 1992 Nov;42(5):864-71. - Pubmed
  • Henley JM, Jenkins R, Hunt SP: Localisation of glutamate receptor binding sites and mRNAs to the dorsal horn of the rat spinal cord. Neuropharmacology. 1993 Jan;32(1):37-41. - Pubmed
  • Li F, Owens N, Verdoorn TA: Functional effects of mutations in the putative agonist binding region of recombinant alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors. Mol Pharmacol. 1995 Jan;47(1):148-54. - Pubmed
DTHybrid score 0.6448
Glutamate--cysteine ligase regulatory subunit
Name Glutamate--cysteine ligase regulatory subunit
Gene Name GCLM
Pharmacological action unknown
Actions Not Available
References
  • Giordano G, White CC, McConnachie LA, Fernandez C, Kavanagh TJ, Costa LG: Neurotoxicity of domoic Acid in cerebellar granule neurons in a genetic model of glutathione deficiency. Mol Pharmacol. 2006 Dec;70(6):2116-26. Epub 2006 Sep 25. - Pubmed
DTHybrid score 0.8144
Glutamate carboxypeptidase 2
Name Glutamate carboxypeptidase 2
Gene Name FOLH1
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Rodriguez CE, Lu H, Martinez AR, Hu Y, Brunelle A, Berkman CE: Inhibition of glutamate carboxypeptidase II by phosphonamidothionate derivatives of glutamic acid. J Enzyme Inhib. 2001 Oct;16(4):359-65. - Pubmed
  • Davis MI, Bennett MJ, Thomas LM, Bjorkman PJ: Crystal structure of prostate-specific membrane antigen, a tumor marker and peptidase. Proc Natl Acad Sci U S A. 2005 Apr 26;102(17):5981-6. Epub 2005 Apr 18. - Pubmed
  • Maung J, Mallari JP, Girtsman TA, Wu LY, Rowley JA, Santiago NM, Brunelle AN, Berkman CE: Probing for a hydrophobic a binding register in prostate-specific membrane antigen with phenylalkylphosphonamidates. Bioorg Med Chem. 2004 Sep 15;12(18):4969-79. - Pubmed
DTHybrid score 2.0184
Glutamate decarboxylase 2
Name Glutamate decarboxylase 2
Gene Name GAD2
Pharmacological action unknown
Actions Not Available
References
  • Wei J, Lin CH, Wu H, Jin Y, Lee YH, Wu JY: Activity-dependent cleavage of brain glutamic acid decarboxylase 65 by calpain. J Neurochem. 2006 Sep;98(5):1688-95. Epub 2006 Jul 31. - Pubmed
  • Manto MU, Laute MA, Aguera M, Rogemond V, Pandolfo M, Honnorat J: Effects of anti-glutamic acid decarboxylase antibodies associated with neurological diseases. Ann Neurol. 2007 Jun;61(6):544-51. - Pubmed
  • Pop SM, Wong CP, He Q, Wang Y, Wallet MA, Goudy KS, Tisch R: The type and frequency of immunoregulatory CD4+ T-cells govern the efficacy of antigen-specific immunotherapy in nonobese diabetic mice. Diabetes. 2007 May;56(5):1395-402. Epub 2007 Feb 22. - Pubmed
  • Wang FY, Zhu RM, Maemura K, Hirata I, Katsu K, Watanabe M: Expression of gamma-aminobutyric acid and glutamic acid decarboxylases in rat descending colon and their relation to epithelial differentiation. Chin J Dig Dis. 2006;7(2):103-8. - Pubmed
  • Castelli MP, Piras AP, Melis T, Succu S, Sanna F, Melis MR, Collu S, Grazia Ennas M, Diaz G, Mackie K, Argiolas A: Cannabinoid CB1 receptors in the paraventricular nucleus and central control of penile erection: immunocytochemistry, autoradiography and behavioral studies. Neuroscience. 2007 Jun 15;147(1):197-206. Epub 2007 May 15. - Pubmed
DTHybrid score 0.87
Glutamate decarboxylase 1
Name Glutamate decarboxylase 1
Gene Name GAD1
Pharmacological action unknown
Actions Not Available
References
  • Akama K, Takaiwa F: C-terminal extension of rice glutamate decarboxylase (OsGAD2) functions as an autoinhibitory domain and overexpression of a truncated mutant results in the accumulation of extremely high levels of GABA in plant cells. J Exp Bot. 2007;58(10):2699-707. Epub 2007 Jun 11. - Pubmed
  • Tueting P, Doueiri MS, Guidotti A, Davis JM, Costa E: Reelin down-regulation in mice and psychosis endophenotypes. Neurosci Biobehav Rev. 2006;30(8):1065-77. - Pubmed
  • Manto MU, Laute MA, Aguera M, Rogemond V, Pandolfo M, Honnorat J: Effects of anti-glutamic acid decarboxylase antibodies associated with neurological diseases. Ann Neurol. 2007 Jun;61(6):544-51. - Pubmed
  • Wang FY, Zhu RM, Maemura K, Hirata I, Katsu K, Watanabe M: Expression of gamma-aminobutyric acid and glutamic acid decarboxylases in rat descending colon and their relation to epithelial differentiation. Chin J Dig Dis. 2006;7(2):103-8. - Pubmed
  • Tronci E, Simola N, Borsini F, Schintu N, Frau L, Carminati P, Morelli M: Characterization of the antiparkinsonian effects of the new adenosine A2A receptor antagonist ST1535: acute and subchronic studies in rats. Eur J Pharmacol. 2007 Jul 2;566(1-3):94-102. Epub 2007 Mar 24. - Pubmed
DTHybrid score 0.7178
Formimidoyltransferase-cyclodeaminase
Name Formimidoyltransferase-cyclodeaminase
Gene Name FTCD
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Gao YS, Alvarez C, Nelson DS, Sztul E: Molecular cloning, characterization, and dynamics of rat formiminotransferase cyclodeaminase, a Golgi-associated 58-kDa protein. J Biol Chem. 1998 Dec 11;273(50):33825-34. - Pubmed
DTHybrid score 0.6929
Glutamate receptor 2
Name Glutamate receptor 2
Gene Name GRIA2
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Henley JM, Jenkins R, Hunt SP: Localisation of glutamate receptor binding sites and mRNAs to the dorsal horn of the rat spinal cord. Neuropharmacology. 1993 Jan;32(1):37-41. - Pubmed
  • Stein E, Cox JA, Seeburg PH, Verdoorn TA: Complex pharmacological properties of recombinant alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate receptor subtypes. Mol Pharmacol. 1992 Nov;42(5):864-71. - Pubmed
  • Li F, Owens N, Verdoorn TA: Functional effects of mutations in the putative agonist binding region of recombinant alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors. Mol Pharmacol. 1995 Jan;47(1):148-54. - Pubmed
DTHybrid score 1.269
Glutamate receptor 3
Name Glutamate receptor 3
Gene Name GRIA3
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Henley JM, Jenkins R, Hunt SP: Localisation of glutamate receptor binding sites and mRNAs to the dorsal horn of the rat spinal cord. Neuropharmacology. 1993 Jan;32(1):37-41. - Pubmed
DTHybrid score 0.8113
Glutamate receptor 4
Name Glutamate receptor 4
Gene Name GRIA4
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Linden AM, Yu H, Zarrinmayeh H, Wheeler WJ, Skolnick P: Binding of an AMPA receptor potentiator ([3H]LY395153) to native and recombinant AMPA receptors. Neuropharmacology. 2001 Jun;40(8):1010-8. - Pubmed
  • Henley JM, Jenkins R, Hunt SP: Localisation of glutamate receptor binding sites and mRNAs to the dorsal horn of the rat spinal cord. Neuropharmacology. 1993 Jan;32(1):37-41. - Pubmed
  • Cristovao AJ, Oliveira CR, Carvalho CM: Expression of AMPA/kainate receptors during development of chick embryo retina cells: in vitro versus in vivo studies. Int J Dev Neurosci. 2002 Feb;20(1):1-9. - Pubmed
DTHybrid score 0.8706
Delta 1-pyrroline-5-carboxylate synthetase
Name Delta 1-pyrroline-5-carboxylate synthetase
Gene Name ALDH18A1
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Morita Y, Nakamori S, Takagi H: L-proline accumulation and freeze tolerance of Saccharomyces cerevisiae are caused by a mutation in the PRO1 gene encoding gamma-glutamyl kinase. Appl Environ Microbiol. 2003 Jan;69(1):212-9. - Pubmed
  • Krishna RV, Beilstein P, Leisinger T: Biosynthesis of proline in Pseudomonas aeruginosa. Properties of gamma-glutamyl phosphate reductase and 1-pyrroline-5-carboxylate reductase. Biochem J. 1979 Jul 1;181(1):223-30. - Pubmed
  • Kamoun P, Aral B, Saudubray JM: [A new inherited metabolic disease: delta1-pyrroline 5-carboxylate synthetase deficiency] Bull Acad Natl Med. 1998;182(1):131-7; discussion 138-9. - Pubmed
DTHybrid score 0.8691
Glutamate receptor, ionotropic kainate 2
Name Glutamate receptor, ionotropic kainate 2
Gene Name GRIK2
Pharmacological action unknown
Actions Not Available
References
  • Wong AY, MacLean DM, Bowie D: Na+/Cl- dipole couples agonist binding to kainate receptor activation. J Neurosci. 2007 Jun 20;27(25):6800-9. - Pubmed
DTHybrid score 0.7026
Glutamate receptor, ionotropic kainate 3
Name Glutamate receptor, ionotropic kainate 3
Gene Name GRIK3
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Bettler B, Egebjerg J, Sharma G, Pecht G, Hermans-Borgmeyer I, Moll C, Stevens CF, Heinemann S: Cloning of a putative glutamate receptor: a low affinity kainate-binding subunit. Neuron. 1992 Feb;8(2):257-65. - Pubmed
  • Takeda M, Haga M, Yamada H, Kinoshita M, Otsuka M, Tsuboi S, Moriyama Y: Ionotropic glutamate receptors expressed in human retinoblastoma Y79 cells. Neurosci Lett. 2000 Nov 17;294(2):97-100. - Pubmed
  • Stuhmer T, Amar M, Harvey RJ, Bermudez I, van Minnen J, Darlison MG: Structure and pharmacological properties of a molluscan glutamate-gated cation channel and its likely role in feeding behavior. J Neurosci. 1996 May 1;16(9):2869-80. - Pubmed
DTHybrid score 0.8708

Transporters


Monocarboxylate transporter 10
Name Monocarboxylate transporter 10
Gene Name SLC16A10
Actions substrate,inhibitor
References
  • Kim DK, Kanai Y, Chairoungdua A, Matsuo H, Cha SH, Endou H: Expression cloning of a Na+-independent aromatic amino acid transporter with structural similarity to H+/monocarboxylate transporters. J Biol Chem. 2001 May 18;276(20):17221-8. Epub 2001 Feb 20. - Pubmed
  • Kim DK, Kanai Y, Matsuo H, Kim JY, Chairoungdua A, Kobayashi Y, Enomoto A, Cha SH, Goya T, Endou H: The human T-type amino acid transporter-1: characterization, gene organization, and chromosomal location. Genomics. 2002 Jan;79(1):95-103. - Pubmed
DTHybrid score 1.147
Monocarboxylate transporter 1
Name Monocarboxylate transporter 1
Gene Name SLC16A1
Actions substrate
References
  • Tamai I, Sai Y, Ono A, Kido Y, Yabuuchi H, Takanaga H, Satoh E, Ogihara T, Amano O, Izeki S, Tsuji A: Immunohistochemical and functional characterization of pH-dependent intestinal absorption of weak organic acids by the monocarboxylic acid transporter MCT1. J Pharm Pharmacol. 1999 Oct;51(10):1113-21. - Pubmed
DTHybrid score 0.5965

Predictions


Id Partner name Gene Name Score
4353 GMP synthase [glutamine-hydrolyzing] guaA 0.9014
5261 Phosphoribosylformylglycinamidine synthase purL 0.9011
3890 Glutamate decarboxylase 2 GAD2 0.87
5493 Tyrosine aminotransferase Not Available 0.7354
3900 Glutamate decarboxylase 1 GAD1 0.7178
4652 Phosphoserine aminotransferase serC 0.717
866 Large neutral amino acids transporter small subunit 2 SLC7A8 0.2523
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.2403
263 Neutral amino acid transporter B(0) SLC1A5 0.2394
3971 CAD protein [Includes: Glutamine-dependent carbamoyl-phosphate synthase CAD 0.2369
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.2353
3990 Protein-glutamine gamma-glutamyltransferase 4 TGM4 0.2277
1008 CTP synthase 1 CTPS 0.2277
3983 Protein-glutamine gamma-glutamyltransferase 5 TGM5 0.2277
3985 Glucosamine--fructose-6-phosphate aminotransferase [isomerizing] 2 GFPT2 0.2276
3989 Glutaminyl-tRNA synthetase QARS 0.2276
3992 Protein-glutamine gamma-glutamyltransferase Z TGM7 0.2276
3988 Protein-glutamine gamma-glutamyltransferase K TGM1 0.2276
3986 Protein-glutamine gamma-glutamyltransferase 6 TGM6 0.2276
169 Cysteine desulfurase, mitochondrial NFS1 0.2259
314 System N amino acid transporter 1 SLC38A3 0.2248
4512 Cytochrome P450 3A4 CYP3A4 0.2207
301 Kynurenine--oxoglutarate transaminase 1 CCBL1 0.2193
2746 4-aminobutyrate aminotransferase gabT 0.2149
6016 Cytochrome P450 2C19 CYP2C19 0.1963
24 Thymidylate synthase TMP1 0.1915
359 Thymidylate synthase TYMS 0.1915
2626 Thymidylate synthase thyA 0.1915
2729 Thymidylate synthase thyA 0.1915
5352 Thymidylate synthase THYA 0.1915
593 Proton-coupled amino acid transporter 1 SLC36A1 0.1905
6030 Cytochrome P450 2B6 CYP2B6 0.1848
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.1761
89 Cysteine sulfinic acid decarboxylase CSAD 0.1732
1596 Protein-glutamine gamma-glutamyltransferase 2 TGM2 0.1666
413 Amidophosphoribosyltransferase PPAT 0.1659
2515 Amidophosphoribosyltransferase purF 0.1659
3714 Amidophosphoribosyltransferase purF 0.1659
6013 Cytochrome P450 2E1 CYP2E1 0.1611
114 Alanine--glyoxylate aminotransferase 2, mitochondrial AGXT2 0.161
358 Cystathionine beta-synthase CBS 0.16
6 Coagulation factor XIII A chain F13A1 0.1574
482 Glycine receptor subunit alpha-1 GLRA1 0.1541
489 Monocarboxylate transporter 2 SLC16A7 0.1533
3899 Alanine--glyoxylate aminotransferase 2-like 2 AGXT2L2 0.147
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.1416
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.1416
868 Cystathionine gamma-lyase CTH 0.1396
3913 Glutamic acid decarboxylase GAD65 0.1383
349 Serine--pyruvate aminotransferase AGXT 0.1374
3977 ASRGL1 protein ASRGL1 0.1372
435 Kynureninase KYNU 0.1335
4654 Kynureninase kynU 0.1335
1387 Inositol monophosphatase 2 IMPA2 0.1283
199 Monocarboxylate transporter 8 SLC16A2 0.1278
500 Monocarboxylate transporter 4 SLC16A3 0.1272
171 Cysteine dioxygenase CDO-1 0.1259
4064 Probable cysteinyl-tRNA synthetase, mitochondrial CARS2 0.1256
1314 Thiamine transporter 2 SLC19A3 0.1255
774 Cysteinyl-tRNA synthetase, cytoplasmic CARS 0.1255
587 Serum albumin ALB 0.1247
798 Osteocalcin BGLAP 0.124
2339 Protein-glutamine gamma-glutamyltransferase E TGM3 0.1238
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.1218
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.1206
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.1155
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.1146
537 ATP synthase delta chain, mitochondrial ATP5D 0.1135
2026 Inositol monophosphatase IMPA1 0.1117
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.1104
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.1103
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.1083
3885 Hypothetical protein DKFZp686P09201 DKFZp686P09201 0.1083
3884 SHMT2 protein SHMT2 0.1083
3901 SHMT2 protein SHMT2 0.1083
3879 Serine hydroxymethyltransferase 2 Not Available 0.1083
321 Serine hydroxymethyltransferase, mitochondrial SHMT2 0.1083
1362 Metabotropic glutamate receptor 2 GRM2 0.106
4096 Metabotropic glutamate receptor 3 GRM3 0.106
207 Glutathione synthetase GSS 0.1038
5269 Glutathione synthetase gshB 0.1038
626 Cysteine dioxygenase type 1 CDO1 0.1012
676 Tyrosine 3-monooxygenase TH 0.1011
575 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial GCAT 0.1007
455 5-aminolevulinate synthase, nonspecific, mitochondrial ALAS1 0.1006
681 Glycine dehydrogenase [decarboxylating], mitochondrial GLDC 0.1006
2632 Adenylosuccinate synthetase purA 0.0983
3323 Adenylosuccinate synthetase purA 0.0983
3975 Adenylosuccinate synthetase ADSS 0.0983
4598 Adenylosuccinate synthetase Adss 0.0983
6817 Adenylosuccinate synthetase purA 0.0983
831 D(2) dopamine receptor DRD2 0.0982
3972 Adenylosuccinate synthetase isozyme 2 ADSS 0.0981
209 Aspartoacylase ASPA 0.0981
3979 Aspartoacylase-2 ACY3 0.0981
533 Aminoacylase-1 ACY1 0.0981
3969 Multifunctional protein ADE2 [Includes: Phosphoribosylaminoimidazole- succinocarboxamide synthase PAICS 0.0981
799 Aspartyl-tRNA synthetase, cytoplasmic DARS 0.098
262 Calcium-binding mitochondrial carrier protein Aralar1 SLC25A12 0.098
513 Calcium-binding mitochondrial carrier protein Aralar2 SLC25A13 0.098
305 Mitochondrial aspartate-glutamate carrier protein SLC25A13 0.098
3976 Aspartyl-tRNA synthetase, mitochondrial DARS2 0.098
2178 Metabotropic glutamate receptor 5 GRM5 0.0964
126 D-lactate dehydrogenase dld 0.0962
3545 D-lactate dehydrogenase Not Available 0.0962
4510 D-lactate dehydrogenase ldhA 0.0962
1999 Methylated-DNA--protein-cysteine methyltransferase MGMT 0.0958
3878 GAD1 protein GAD1 0.0942
534 Threonine synthase-like 1 THNSL1 0.0938
3874 Proline synthetase co-transcribed bacterial homolog protein PROSC 0.093
3908 P-selectin cytoplasmic tail-associated protein pcap 0.0926
3896 CDNA FLJ46802 fis, clone TRACH3032150, moderately similar to Cysteine sulfinic acid decarboxylase GADL1 0.0926
3915 Cysteine sulfinic acid decarboxylase-related protein 1 CSAD 0.0926
3887 Phosphorylase PYGB 0.0925
3911 Uncharacterized protein C20orf38 SPTLC3 0.0925
3881 Selenocysteine lyase variant Not Available 0.0925
3891 Putative L-Dopa decarboxylase DDC 0.0925
3906 Serine dehydratase-like SDSL 0.0925
306 Pyridoxal phosphate phosphatase PDXP 0.0925
3914 Alanine-glyoxylate aminotransferase homolog TLH6 0.0925
3883 Ornithine aminotransferase variant Not Available 0.0925
3893 DDC protein DDC 0.0925
3910 O-phosphoseryl-tRNA(Sec) selenium transferase SEPSECS 0.0925
3909 Hepatic peroxysomal alanine:glyoxylate aminotransferase Not Available 0.0925
3880 Serine hydroxymethyltransferase 1 Not Available 0.0924
855 Sphingosine-1-phosphate lyase 1 SGPL1 0.0924
3903 Aminolevulinate, delta-, synthase 2 ALAS2 0.0924
3886 Migration-inducing protein 4 ALAS1 0.0924
3894 KIAA0251 protein PDXDC1 0.0924
3882 Brain glycogen phosphorylase variant Not Available 0.0924
3905 Molybdenum cofactor sulfurase MOCOS 0.0924
3875 Glycogen phosphorylase, brain form PYGB 0.0924
3193 Serine hydroxymethyltransferase glyA 0.0922
3342 Serine hydroxymethyltransferase glyA 0.0922
367 Serine hydroxymethyltransferase, cytosolic SHMT1 0.0917
399 Tyrosyl-tRNA synthetase, mitochondrial YARS2 0.0909
246 Valyl-tRNA synthetase VARS 0.0906
701 Isoleucine-tRNA synthetase IARS 0.0895
4080 Isoleucyl-tRNA synthetase, mitochondrial IARS2 0.0895
546 Isoleucyl-tRNA synthetase, cytoplasmic IARS 0.0895
3 Histidine decarboxylase HDC 0.0894
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0872
184 L-serine dehydratase SDS 0.0859
431 Serine racemase SRR 0.0859
491 Serine palmitoyltransferase 1 SPTLC1 0.0859
727 Serine palmitoyltransferase 2 SPTLC2 0.0859
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0852
4118 Cytochrome P450 3A5 CYP3A5 0.0843
585 Aspartyl/asparaginyl beta-hydroxylase ASPH 0.0837
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0835
365 Dihydrofolate reductase DHFR 0.0821
2381 Dihydrofolate reductase DFR1 0.0821
2833 Dihydrofolate reductase Not Available 0.0821
2931 Dihydrofolate reductase folA 0.0821
3544 Dihydrofolate reductase folA 0.0821
3682 Dihydrofolate reductase folA 0.0821
6642 Dihydrofolate reductase folA 0.0821
6756 Dihydrofolate reductase dfrA 0.0821
499 Arginine decarboxylase ADC 0.082
532 Neutral amino acid transporter A SLC1A4 0.0813
323 Alanyl-tRNA synthetase, cytoplasmic AARS 0.0813
4070 Probable alanyl-tRNA synthetase, mitochondrial AARS2 0.0813
3999 Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial SDHD 0.0809
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0796
740 Argininosuccinate synthase ASS1 0.0789
865 Argininosuccinate synthase ASS1 0.0789
2680 Argininosuccinate synthase argG 0.0789
3194 Argininosuccinate synthase argG 0.0789
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0774
501 Leucine carboxyl methyltransferase 1 LCMT1 0.0773
675 Leucine carboxyl methyltransferase 2 LCMT2 0.0773
227 Probable leucyl-tRNA synthetase, mitochondrial LARS2 0.0772
846 Leucyl-tRNA synthetase, cytoplasmic LARS 0.0772
3082 Aminomethyltransferase gcvT 0.0762
502 5-hydroxytryptamine 2A receptor HTR2A 0.0759
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0752
3257 Bifunctional polymyxin resistance protein arnA arnA 0.075
5072 N,N-dimethylglycine oxidase dmg 0.0747
1721 Glycogen synthase kinase-3 beta GSK3B 0.0738
601 Propionyl-CoA carboxylase beta chain, mitochondrial PCCB 0.073
5718 Cytochrome P450 2A6 CYP2A6 0.073
5469 Head decoration protein shp 0.073
3978 Adenylosuccinate synthetase isozyme 1 ADSSL1 0.0727
4119 Cytochrome P450 2D6 CYP2D6 0.0719
19 Coagulation factor VIII F8 0.0706
31 Phenylalanyl-tRNA synthetase, mitochondrial FARS2 0.0684
42 Phenylalanyl-tRNA synthetase alpha chain FARSA 0.0684
6602 Phenylalanyl-tRNA synthetase alpha chain pheS 0.0684
618 Phenylalanyl-tRNA synthetase beta chain FARSB 0.0684
6603 Phenylalanyl-tRNA synthetase beta chain pheT 0.0684
1799 Glucose-6-phosphate 1-dehydrogenase G6PD 0.0683
2630 Glucose-6-phosphate 1-dehydrogenase zwf 0.0683
472 Ornithine aminotransferase, mitochondrial OAT 0.0672
2826 Glucose--fructose oxidoreductase gfo 0.0671
696 Kappa-type opioid receptor OPRK1 0.0652
369 Coagulation factor VII F7 0.0652
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0649
203 Pyridoxine-5'-phosphate oxidase PNPO 0.0649
669 Asparaginyl-tRNA synthetase, cytoplasmic NARS 0.0629
4092 Probable asparaginyl-tRNA synthetase, mitochondrial NARS2 0.0629
3998 B(0,+)-type amino acid transporter 1 SLC7A9 0.0628
38 Cystinosin CTNS 0.0626
1963 Neutral and basic amino acid transport protein rBAT SLC3A1 0.0626
471 Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) SLC6A14 0.0596
2675 Pteridine reductase 1 PTR1 0.0595
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0587
256 Tyrosyl-tRNA synthetase, cytoplasmic YARS 0.0572
341 5-hydroxytryptamine 3 receptor HTR3A 0.0571
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0571
4757 Cytochrome P450 2C9 CYP2C9 0.0568
449 Ornithine decarboxylase ODC1 0.0567
3184 3-methyl-2-oxobutanoate hydroxymethyltransferase panB 0.0566
3315 3-methyl-2-oxobutanoate hydroxymethyltransferase panB 0.0566
3179 2-isopropylmalate synthase leuA 0.0565
1483 Membrane copper amine oxidase AOC3 0.0542
240 Gamma-aminobutyric acid type B receptor, subunit 1 GABBR1 0.054
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0537
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0534
1334 Tissue factor pathway inhibitor TFPI 0.0521
4200 Cytochrome P450 1A2 CYP1A2 0.0515
4924 Cytochrome P450 2C8 CYP2C8 0.0506
6144 Solute carrier family 22 member 2 SLC22A2 0.0506
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0504
820 Glycine receptor subunit alpha-2 GLRA2 0.0497
239 Coagulation factor X F10 0.0497
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0496
2823 Trypanothione reductase TPR 0.0494
6024 Cytochrome P450 1A1 CYP1A1 0.049
592 Carbonic anhydrase 4 CA4 0.0487
10 Glycogen phosphorylase, liver form PYGL 0.0485
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0471
357 Carbonic anhydrase 2 CA2 0.0458
3334 Deacetoxycephalosporin C synthetase cefE 0.0457
5682 Ribonuclease pancreatic RNASE1 0.0448
461 Glycine receptor subunit alpha-3 GLRA3 0.0447
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0446
1729 Solute carrier family 22 member 6 SLC22A6 0.0436
2537 Aromatic-amino-acid aminotransferase tyrB 0.0434
2249 Aspartate aminotransferase aspC 0.043
2671 Aspartate aminotransferase aspC 0.043
5490 Aspartate aminotransferase Not Available 0.043
3917 Methylenetetrahydrofolate reductase MTHFR 0.0427
824 Sodium-dependent serotonin transporter SLC6A4 0.0422
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0418
1588 Multidrug resistance protein 1 ABCB1 0.0418
492 Histamine H1 receptor HRH1 0.0414
1566 Corticoliberin CRH 0.0413
3831 Low-density lipoprotein receptor-related protein 1 LRP1 0.0411
6142 Solute carrier family 22 member 8 SLC22A8 0.0411
828 Phenylalanine-4-hydroxylase PAH 0.0401
3109 Phenylalanine-4-hydroxylase phhA 0.0401
6107 Cytochrome P450 3A7 CYP3A7 0.0397
6031 Cytochrome P450 3A43 CYP3A43 0.0391
3939 Amine oxidase [flavin-containing] B MAOB 0.0385
3923 Cholinesterase BCHE 0.0385
2139 Tissue factor F3 0.0381
1152 Glycogen phosphorylase, muscle form PYGM 0.0364
3851 Serine protease hepsin HPN 0.0363
1245 Vitamin K-dependent protein S PROS1 0.0339
174 Sigma 1-type opioid receptor SIGMAR1 0.0331
3941 Amine oxidase [flavin-containing] A MAOA 0.0324
85 Growth hormone receptor GHR 0.0319
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0318
20 Prostaglandin G/H synthase 1 PTGS1 0.0317
54 Prothrombin F2 0.0315
1959 Platelet factor 4 PF4 0.0299
4057 Glycine N-acyltransferase GLYAT 0.0299
4059 Glycine N-acyltransferase-like protein 1 GLYATL1 0.0299
4061 Peroxisomal sarcosine oxidase PIPOX 0.0299
4058 Glycine N-acyltransferase-like protein 2 GLYATL2 0.0299
4056 N-arachidonyl glycine receptor GPR18 0.0299
4055 Bile acid CoA:amino acid N-acyltransferase BAAT 0.0299
4060 Vesicular inhibitory amino acid transporter SLC32A1 0.0299
3865 Serpin B6 SERPINB6 0.0299
1088 5-aminolevulinate synthase, erythroid-specific, mitochondrial ALAS2 0.0299
1236 Sodium- and chloride-dependent glycine transporter 1 SLC6A9 0.0299
1466 Glycyl-tRNA synthetase GARS 0.0299
4062 Sodium- and chloride-dependent glycine transporter 2 SLC6A5 0.0299
1986 Ceruloplasmin CP 0.0299
1650 Heme carrier protein 1 SLC46A1 0.0299
1024 Solute carrier family 22 member 11 SLC22A11 0.0298
16 Adenosine A1 receptor ADORA1 0.0297
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0293
2744 D-alanine aminotransferase dat 0.0291
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0287
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0287
6645 D-amino-acid oxidase DAO 0.0286
2532 Pantoate--beta-alanine ligase panC 0.0285
468 Cytochrome P450 4A11 CYP4A11 0.0279
862 Multidrug resistance-associated protein 1 ABCC1 0.0278
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0277
809 Methionine synthase MTR 0.0276
2935 Methionine synthase metH 0.0276
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0274
4077 Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform PPP2CB 0.0274
375 SEC14-like protein 3 SEC14L3 0.0274
86 SEC14-like protein 4 SEC14L4 0.0274
4076 Diacylglycerol kinase alpha DGKA 0.0274
275 Arachidonate 5-lipoxygenase ALOX5 0.0272
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0271
1268 Neuropeptide S receptor NPSR1 0.0271
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0271
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0271
1547 Coagulation factor XI F11 0.0269
6145 Solute carrier family 22 member 1 SLC22A1 0.0262
296 Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial MTHFD2 0.0262
6070 Nischarin NISCH 0.0261
3833 Plasma serine protease inhibitor SERPINA5 0.026
110 Pyruvate dehydrogenase E1 component subunit beta, mitochondrial PDHB 0.026
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0257
23 D(1A) dopamine receptor DRD1 0.0253
2749 UDP-4-amino-4-deoxy-L-arabinose--oxoglutarate aminotransferase arnB 0.0251
2842 Glutamate-1-semialdehyde 2,1-aminomutase hemL 0.0251
13 Aminomethyltransferase, mitochondrial AMT 0.0251
2929 (S)-2-haloacid dehalogenase dhlB 0.0248
2995 (S)-2-haloacid dehalogenase Not Available 0.0248
2164 Multidrug resistance-associated protein 4 ABCC4 0.0247
3920 Methylenetetrahydrofolate reductase intermediate form MTHFR 0.0244
3763 5,10-methylenetetrahydrofolate reductase metF 0.0243
3918 5,10-methylenetetrahydrofolate reductase MTHFR 0.0243
5094 5,10-methylenetetrahydrofolate reductase metF 0.0243
59 AMT protein AMT 0.0243
3919 Methionyl-tRNA formyltransferase, mitochondrial MTFMT 0.0243
1202 10-formyltetrahydrofolate dehydrogenase ALDH1L1 0.0243
5650 NimA-related protein DR_0842 0.0243
6106 Cytochrome P450 2C18 CYP2C18 0.0242
62 Glycine receptor subunit beta GLRB 0.0239
46 Coagulation factor V F5 0.0236
2021 Thrombomodulin THBD 0.0235
2546 Histidinol-phosphate aminotransferase hisC 0.0235
2698 Histidinol-phosphate aminotransferase hisC 0.0235
802 Pyrroline-5-carboxylate reductase 2 PYCR2 0.0234
248 Pyrroline-5-carboxylate reductase 1 PYCR1 0.0234
6073 Potassium channel subfamily K member 9 KCNK9 0.0233
6072 Potassium channel subfamily K member 3 KCNK3 0.0233
5925 Neuropeptide Y NPY 0.0231
2072 Endothelial protein C receptor PROCR 0.023
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.023
899 Glutathione S-transferase Mu 3 GSTM3 0.0227
905 Glutathione transferase omega-1 GSTO1 0.0227
283 SEC14-like protein 2 SEC14L2 0.0227
4054 Glycine cleavage system H protein, mitochondrial GCSH 0.0226
397 Monocarboxylate transporter 3 SLC16A8 0.0226
218 Monocarboxylate transporter 5 SLC16A4 0.0226
195 Monocarboxylate transporter 7 SLC16A6 0.0226
429 Monocarboxylate transporter 6 SLC16A5 0.0225
1673 GTP cyclohydrolase I GCH1 0.0225
3302 GTP cyclohydrolase I folE 0.0225
3209 Ornithine decarboxylase, inducible odcI 0.0225
776 Bile salt export pump ABCB11 0.0225
6020 Aldehyde oxidase AOX1 0.0224
6143 Solute carrier family 22 member 7 SLC22A7 0.0224
679 C-1-tetrahydrofolate synthase, cytoplasmic MTHFD1 0.0223
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0222
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.022
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0218
78 Acetyl-CoA acetyltransferase, mitochondrial ACAT1 0.0218
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0217
708 Alpha-tocopherol transfer protein TTPA 0.0216
810 Heme oxygenase 1 HMOX1 0.0214
3391 Heme oxygenase 1 pbsA1 0.0214
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0212
411 Glycine N-methyltransferase GNMT 0.0211
118 Organic cation/carnitine transporter 2 SLC22A5 0.0211
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0209
159 Penicillin-binding protein 2B penA 0.0207
6121 Penicillin-binding protein 2B penA 0.0207
383 Glycine amidinotransferase, mitochondrial GATM 0.0206
4078 Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform PPP2CA 0.0201
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0199
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0198
4069 Threonyl-tRNA synthetase, mitochondrial TARS2 0.0197
261 Threonyl-tRNA synthetase, cytoplasmic TARS 0.0197
3085 Molybdopterin-guanine dinucleotide biosynthesis protein A mobA 0.0197
267 Plasminogen activator inhibitor 1 SERPINE1 0.0196
3335 Probable GTP-binding protein engB engB 0.0196
3354 Ras-related protein Rap-2a RAP2A 0.0196
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0196
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0196
3311 mRNA-capping enzyme A103R 0.0195
894 Alanine racemase alr 0.0195
2453 Alanine racemase alr 0.0195
997 Protein kinase C beta type PRKCB 0.0195
2647 RNA-directed RNA polymerase P2 0.0193
52 Pyruvate kinase isozymes R/L PKLR 0.0191
3254 Bifunctional protein putA [Includes: Proline dehydrogenase putA 0.0189
4083 Peptidyl-prolyl cis-trans isomerase H PPIH 0.0189
4085 Peptidyl-prolyl cis-trans isomerase C PPIC 0.0189
4087 Pyrroline 5-carboxylate reductase isoform P5CR2 0.0189
4090 Chromosome 14 open reading frame 149 C14orf149 0.0189
4088 Probable prolyl-tRNA synthetase, mitochondrial PARS2 0.0189
4082 Proline oxidase, mitochondrial PRODH 0.0189
4086 Peptidyl-prolyl cis-trans isomerase G PPIG 0.0189
797 Sodium-dependent proline transporter SLC6A7 0.0189
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0188
713 Sodium-dependent dopamine transporter SLC6A3 0.0184
466 Solute carrier family 12 member 3 SLC12A3 0.0184
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0184
771 Pyruvate carboxylase, mitochondrial PC 0.0184
317 Methionine-R-sulfoxide reductase SEPX1 0.0183
480 Methionine-R-sulfoxide reductase B2 MSRB2 0.0182
3996 Betaine--homocysteine S-methyltransferase 2 BHMT2 0.0182
3921 Methionine adenosyltransferase 2 subunit beta MAT2B 0.0182
1970 Protein kinase C alpha type PRKCA 0.0182
3995 Methionyl-tRNA synthetase, mitochondrial MARS2 0.0182
600 Methionyl-tRNA synthetase, cytoplasmic MARS 0.0182
5818 Folate receptor alpha FOLR1 0.0179
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0178
2293 Cyclomaltodextrin glucanotransferase Not Available 0.0177
2508 Cyclomaltodextrin glucanotransferase cgt 0.0177
2523 Cyclomaltodextrin glucanotransferase cgt 0.0177
3207 Cyclomaltodextrin glucanotransferase amyA 0.0177
4084 Peptidyl-prolyl cis-trans isomerase B PPIB 0.0175
290 Prostaglandin G/H synthase 2 PTGS2 0.0173
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0172
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.017
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.017
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.017
98 Pyruvate kinase isozymes M1/M2 PKM2 0.0169
318 Alpha-2A adrenergic receptor ADRA2A 0.0168
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0165
2207 Rhodopsin RHO 0.0165
378 Alpha-2C adrenergic receptor ADRA2C 0.0164
2554 Peptidyl-prolyl cis-trans isomerase, mitochondrial PPIF 0.0164
453 S-adenosylmethionine synthetase isoform type-1 MAT1A 0.0163
3932 Glutathione S-transferase A2 GSTA2 0.0161
1750 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 PFKFB1 0.0161
251 Alcohol dehydrogenase 1A ADH1A 0.016
1758 GTPase HRas HRAS 0.016
2457 Bacillolysin nprS 0.016
556 Alpha-1A adrenergic receptor ADRA1A 0.0157
604 Vitamin K-dependent protein Z PROZ 0.0156
4081 Vitamin K epoxide reductase complex subunit 1-like protein 1 VKORC1L1 0.0156
4000 Prolyl 4-hydroxylase subunit alpha-2 P4HA2 0.0156
6148 Multidrug resistance-associated protein 7 ABCC10 0.0156
191 Peptide methionine sulfoxide reductase MSRA 0.0155
293 Gamma-glutamyl hydrolase GGH 0.0155
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0154
816 Biliverdin reductase A BLVRA 0.0153
579 Alcohol dehydrogenase class 4 mu/sigma chain ADH7 0.0153
316 4-trimethylaminobutyraldehyde dehydrogenase ALDH9A1 0.0153
792 Aldehyde dehydrogenase, dimeric NADP-preferring ALDH3A1 0.0153
334 S-adenosylmethionine synthetase isoform type-2 MAT2A 0.0151
6316 ADP-ribosylation factor 1 ARF1 0.015
338 DNA polymerase UL30 0.0149
379 DNA polymerase UL54 0.0149
697 DNA polymerase ORF28 0.0149
2482 DNA polymerase 43 0.0149
4104 DNA polymerase BALF5 0.0149
295 Carbonic anhydrase 1 CA1 0.0149
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0147
815 Histidyl-tRNA synthetase, cytoplasmic HARS 0.0147
96 Histidine ammonia-lyase HAL 0.0147
6257 Histidine ammonia-lyase Not Available 0.0147
6536 Histidine ammonia-lyase hutH 0.0147
2461 D-alanyl-D-alanine carboxypeptidase Not Available 0.0147
5756 D-alanyl-D-alanine carboxypeptidase dac 0.0147
941 Betaine--homocysteine S-methyltransferase 1 BHMT 0.0147
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0146
400 Coagulation factor IX F9 0.0146
5461 Coagulation factor IX F9 0.0146
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0143
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0143
444 Alcohol dehydrogenase 1B ADH1B 0.0143
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0142
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0141
6141 Sodium/bile acid cotransporter SLC10A1 0.0139
4132 Chloride channel protein ClC-Ka CLCNKA 0.0139
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0138
3949 Prolyl 3-hydroxylase 2 LEPREL1 0.0138
3945 Prolyl 3-hydroxylase 1 LEPRE1 0.0138
3951 Prolyl 3-hydroxylase 3 LEPREL2 0.0138
150 Cationic amino acid transporter 3 SLC7A3 0.0137
235 High-affinity cationic amino acid transporter 1 SLC7A1 0.0137
58 Cationic amino acid transporter 4 SLC7A4 0.0137
350 3-hydroxyacyl-CoA dehydrogenase type-2 HSD17B10 0.0137
646 Malate dehydrogenase, cytoplasmic MDH1 0.0137
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0136
178 NADH-cytochrome b5 reductase 3 CYB5R3 0.0136
812 Dihydrolipoyl dehydrogenase, mitochondrial DLD 0.0136
454 Peroxisomal multifunctional enzyme type 2 HSD17B4 0.0136
363 NADP-dependent malic enzyme, mitochondrial ME3 0.0134
597 Dihydropteridine reductase QDPR 0.0133
328 Sorbitol dehydrogenase SORD 0.0133
6147 Solute carrier family 22 member 3 SLC22A3 0.0133
396 Alcohol dehydrogenase 4 ADH4 0.0133
904 Glutathione S-transferase P GSTP1 0.0133
840 Methionine synthase reductase, mitochondrial MTRR 0.0132
340 Apoptotic protease-activating factor 1 APAF1 0.0131
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0127
422 Vitamin K-dependent protein C PROC 0.0127
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.0127
419 Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial HADH 0.0126
12 Alcohol dehydrogenase class 3 ADH5 0.0124
77 L-lactate dehydrogenase B chain LDHB 0.0123
517 Alcohol dehydrogenase 1C ADH1C 0.0123
694 Matrix protein 2 M 0.0121
3947 Xanthine dehydrogenase/oxidase XDH 0.012
617 Muscarinic acetylcholine receptor M2 CHRM2 0.012
599 Glyceraldehyde-3-phosphate dehydrogenase GAPDH 0.0119
4426 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0119
4454 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0119
4489 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0119
569 Retinal dehydrogenase 2 ALDH1A2 0.0118
473 L-lactate dehydrogenase A chain LDHA 0.0117
465 Calmodulin CALM1 0.0117
1039 Histone deacetylase 9 HDAC9 0.0116
794 Glyceraldehyde-3-phosphate dehydrogenase, testis-specific GAPDHS 0.0116
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0115
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0115
2297 Genome polyprotein Not Available 0.0114
2322 Genome polyprotein Not Available 0.0114
2694 Genome polyprotein Not Available 0.0114
2719 Genome polyprotein Not Available 0.0114
2860 Genome polyprotein Not Available 0.0114
2928 Genome polyprotein Not Available 0.0114
3160 Genome polyprotein Not Available 0.0114
3260 Genome polyprotein Not Available 0.0114
4783 Genome polyprotein Not Available 0.0114
5726 Genome polyprotein Not Available 0.0114
5779 Genome polyprotein Not Available 0.0114
5867 Genome polyprotein Not Available 0.0114
6253 Genome polyprotein Not Available 0.0114
6301 Genome polyprotein Not Available 0.0114
6380 Genome polyprotein Not Available 0.0114
6381 Genome polyprotein Not Available 0.0114
6437 Genome polyprotein Not Available 0.0114
6520 Genome polyprotein Not Available 0.0114
6521 Genome polyprotein Not Available 0.0114
6652 Genome polyprotein Not Available 0.0114
6734 Genome polyprotein Not Available 0.0114
6735 Genome polyprotein Not Available 0.0114
6736 Genome polyprotein Not Available 0.0114
6737 Genome polyprotein Not Available 0.0114
6738 Genome polyprotein Not Available 0.0114
6739 Genome polyprotein Not Available 0.0114
6744 Genome polyprotein Not Available 0.0114
6748 Genome polyprotein Not Available 0.0114
6894 Genome polyprotein Not Available 0.0114
6898 Genome polyprotein Not Available 0.0114
3587 Gastrotropin FABP6 0.0114
638 D(3) dopamine receptor DRD3 0.0113
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0112
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0112
611 Retinal dehydrogenase 1 ALDH1A1 0.0112
166 NAD-dependent malic enzyme, mitochondrial ME2 0.0111
5251 Carbonyl reductase [NADPH] 1 CBR1 0.011
221 Lysyl-tRNA synthetase KARS 0.0109
833 Organic cation/carnitine transporter 1 SLC22A4 0.0106
928 Nicotinic acid receptor 2 GPR109B 0.0105
860 Nicotinamide N-methyltransferase NNMT 0.0105
583 Nicotinate-nucleotide pyrophosphorylase [carboxylating] QPRT 0.0105
2442 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0105
2459 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0105
699 Nicotinic acid receptor 1 GPR109A 0.0105
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0103
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0102
2795 Methionine aminopeptidase 2 METAP2 0.0101
72 Seryl-tRNA synthetase, cytoplasmic SARS 0.0099
427 Substance-P receptor TACR1 0.0098
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0098
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0098
619 Low-affinity cationic amino acid transporter 2 SLC7A2 0.0095
172 Potassium channel subfamily K member 1 KCNK1 0.0095
6167 Organic solute transporter subunit beta OSTB 0.0094
6166 Organic solute transporter subunit alpha OSTA 0.0094
247 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 NDUFA1 0.0094
755 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 NDUFA3 0.0094
300 NADH-ubiquinone oxidoreductase chain 4L MT-ND4L 0.0094
353 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 NDUFA4L2 0.0094
374 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 NDUFB1 0.0094
190 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4 NDUFA4 0.0094
343 NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial NDUFC1 0.0094
607 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 NDUFA2 0.0094
446 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 NDUFA7 0.0094
270 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial NDUFB5 0.0094
405 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 NDUFA8 0.0094
30 NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial NDUFV3 0.0094
324 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 NDUFB4 0.0094
568 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 NDUFB7 0.0094
582 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 NDUFA13 0.0094
313 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 NDUFB3 0.0094
219 NADH-ubiquinone oxidoreductase chain 3 MT-ND3 0.0094
829 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 NDUFA12 0.0094
602 Acyl carrier protein, mitochondrial NDUFAB1 0.0094
525 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 NDUFA5 0.0094
104 NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial NDUFS6 0.0094
746 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial NDUFB8 0.0094
475 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial NDUFB2 0.0094
99 NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 NDUFS5 0.0094
417 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 NDUFB6 0.0094
384 NADH-ubiquinone oxidoreductase chain 6 MT-ND6 0.0094
41 NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial NDUFS8 0.0094
167 L-lactate dehydrogenase C chain LDHC 0.0094
326 L-lactate dehydrogenase A-like 6A LDHAL6A 0.0094
152 NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial NDUFV2 0.0094
236 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 NDUFA6 0.0094
91 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial NDUFA10 0.0094
609 15-hydroxyprostaglandin dehydrogenase [NAD+] HPGD 0.0094
112 L-lactate dehydrogenase A-like 6B LDHAL6B 0.0094
206 3-keto-steroid reductase HSD17B7 0.0094
598 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 NDUFA11 0.0094
272 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 NDUFB10 0.0094
216 Aldehyde dehydrogenase 3B2 ALDH3B2 0.0094
656 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 NDUFB9 0.0094
372 Estradiol 17-beta-dehydrogenase 3 HSD17B3 0.0094
644 Heme oxygenase 2 HMOX2 0.0094
4982 Heme oxygenase 2 pbsA2 0.0094
608 NADH-ubiquinone oxidoreductase chain 4 MT-ND4 0.0094
107 C-4 methylsterol oxidase SC4MOL 0.0094
141 3-hydroxyisobutyrate dehydrogenase, mitochondrial HIBADH 0.0094
721 NADH-ubiquinone oxidoreductase chain 2 MT-ND2 0.0094
555 NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial NDUFS4 0.0094
729 GDP-L-fucose synthetase TSTA3 0.0094
3463 GDP-L-fucose synthetase fcl 0.0094
14 Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial IDH3A 0.0094
487 Aldo-keto reductase family 1 member C4 AKR1C4 0.0094
662 Fatty aldehyde dehydrogenase ALDH3A2 0.0094
50 Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating NSDHL 0.0094
335 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial NDUFA9 0.0094
539 NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial NDUFV1 0.0094
196 D-beta-hydroxybutyrate dehydrogenase, mitochondrial BDH1 0.0094
848 Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial IDH3G 0.0094
231 Glycerol-3-phosphate dehydrogenase [NAD+], cytoplasmic GPD1 0.0094
9 Estradiol 17-beta-dehydrogenase 2 HSD17B2 0.0094
496 Aldehyde dehydrogenase 3B1 ALDH3B1 0.0094
671 Pyruvate dehydrogenase E1 component alpha subunit, testis-specific form, mitochondrial PDHA2 0.0094
628 Pyruvate dehydrogenase E1 component alpha subunit, somatic form, mitochondrial PDHA1 0.0094
271 Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial ALDH4A1 0.0094
145 Corticosteroid 11-beta-dehydrogenase isozyme 2 HSD11B2 0.0094
637 NADH-ubiquinone oxidoreductase chain 5 MT-ND5 0.0094
180 D-3-phosphoglycerate dehydrogenase PHGDH 0.0094
3726 D-3-phosphoglycerate dehydrogenase serA 0.0094
4291 D-3-phosphoglycerate dehydrogenase serA 0.0094
34 7-dehydrocholesterol reductase DHCR7 0.0094
711 UDP-glucose 6-dehydrogenase UGDH 0.0094
3672 UDP-glucose 6-dehydrogenase hasB 0.0094
149 Alpha-aminoadipic semialdehyde dehydrogenase ALDH7A1 0.0094
531 Aldehyde dehydrogenase X, mitochondrial ALDH1B1 0.0094
258 Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial ALDH6A1 0.0094
643 Peroxisomal bifunctional enzyme EHHADH 0.0094
548 NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial NDUFS1 0.0094
616 Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial IDH3B 0.0094
393 GDH/6PGL endoplasmic bifunctional protein [Includes: Glucose 1-dehydrogenase H6PD 0.0094
288 Trifunctional enzyme subunit alpha, mitochondrial HADHA 0.0094
486 Serine/threonine-protein kinase ALS2CR7 CDK15 0.0093
483 A-Raf proto-oncogene serine/threonine-protein kinase ARAF 0.0093
510 Serine/threonine-protein kinase receptor R3 ACVRL1 0.0093
733 Activin receptor type 1B ACVR1B 0.0093
225 NEDD8-activating enzyme E1 regulatory subunit NAE1 0.0093
745 Anti-Muellerian hormone type-2 receptor AMHR2 0.0093
825 Arsenical pump-driving ATPase ASNA1 0.0093
3435 Arsenical pump-driving ATPase arsA 0.0093
2105 ATP-binding cassette sub-family G member 1 ABCG1 0.0093
21 Beta-adrenergic receptor kinase 2 ADRBK2 0.0093
377 Beta-adrenergic receptor kinase 1 ADRBK1 0.0093
154 AFG3-like protein 2 AFG3L2 0.0093
395 ALK tyrosine kinase receptor Not Available 0.0093
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0093
3937 Fatty-acid amide hydrolase FAAH 0.0092
714 Glutathione reductase, mitochondrial GSR 0.0091
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0086
2683 Mono-ADP-ribosyltransferase C3 C3 0.0086
6500 Phospholipase A2 PLA2G1B 0.0085
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0085
6149 Solute carrier family 22 member 10 SLC22A10 0.0083
635 Estradiol 17-beta-dehydrogenase 8 HSD17B8 0.0082
666 NADP-dependent malic enzyme ME1 0.0082
857 Malate dehydrogenase, mitochondrial MDH2 0.0082
467 Delta-type opioid receptor OPRD1 0.0082
821 Acetyl-coenzyme A synthetase 2-like, mitochondrial ACSS1 0.0079
704 Long-chain-fatty-acid--CoA ligase 1 ACSL1 0.0079
386 Acetyl-coenzyme A synthetase, cytoplasmic ACSS2 0.0079
297 Adenylate cyclase type 1 ADCY1 0.0079
4495 3-oxoacyl-(Acyl carrier protein) reductase TM_1169 0.0078
4435 L-aspartate dehydrogenase nadX 0.0078
4428 Redox-sensing transcriptional repressor rex rex 0.0078
4414 Dehydrogenase TT_P0035 0.0078
2350 3-isopropylmalate dehydrogenase leuB 0.0078
3092 3-isopropylmalate dehydrogenase leuB 0.0078
4455 Glycerol dehydrogenase gldA 0.0078
4497 Benzyl alcohol dehydrogenase xylB 0.0078
4449 ADP-ribosyltransferase Not Available 0.0078
4466 Glutathione-independent formaldehyde dehydrogenase fdhA 0.0078
4446 3alpha-hydroxysteroid dehydrogenase/carbonyl reductase Not Available 0.0078
4472 Glucose 1-dehydrogenase Not Available 0.0078
4423 Levodione reductase lvr 0.0078
4505 Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase bphB 0.0078
4443 Quinate/shikimate dehydrogenase ydiB 0.0078
4456 Inorganic polyphosphate/ATP-NAD kinase ppnK 0.0078
4448 L-2-hydroxyisocaproate dehydrogenase Not Available 0.0078
4500 L-lactate dehydrogenase 2 ldh2 0.0078
4447 Hypothetical protein yhfP yhfP 0.0078
4336 Glyceraldehyde 3-phosphate dehydrogenase Not Available 0.0078
4436 Glyceraldehyde 3-phosphate dehydrogenase tthHB8IM 0.0078
3381 Alcohol dehydrogenase Not Available 0.0078
4508 Alcohol dehydrogenase adhA 0.0078
4418 AGR_L_3209p AGR_L_3209 0.0078
4507 Alanine dehydrogenase ald 0.0078
4475 Hypothetical protein Rv0046c/MT0052 ino1 0.0078
4506 Myo-inositol-1-phosphate synthase-related protein TM_1419 0.0078
3735 NAD(P) transhydrogenase subunit alpha part 1 pntAA 0.0078
4502 Formate dehydrogenase Not Available 0.0078
4487 Transcriptional regulator nadR nadR 0.0078
3729 Citrate synthase gltA 0.0078
4575 Citrate synthase cit 0.0078
4580 Citrate synthase gltA 0.0078
4451 Vip2Ac vip2Ac 0.0078
4467 Alpha-glucosidase, putative TM_0752 0.0078
4471 CDP-D-glucose-4,6-dehydratase ascB 0.0078
289 Cytosolic purine 5'-nucleotidase NT5C2 0.0078
847 Mu-type opioid receptor OPRM1 0.0078
6026 Alcohol dehydrogenase 6 ADH6 0.0077
292 Activin receptor type-1 ACVR1 0.0076
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0076
849 Activated CDC42 kinase 1 TNK2 0.0076
723 Cytosolic phospholipase A2 PLA2G4A 0.0076
11 NAD(P) transhydrogenase, mitochondrial NNT 0.0075
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0075
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0075
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0075
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0075
839 Short-chain specific acyl-CoA dehydrogenase, mitochondrial ACADS 0.0075
627 11-cis retinol dehydrogenase RDH5 0.0075
640 Aldehyde dehydrogenase 1A3 ALDH1A3 0.0074
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0074
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0074
90 Tryptophan 5-hydroxylase 2 TPH2 0.0073
4063 Tryptophanyl-tRNA synthetase, mitochondrial WARS2 0.0073
74 Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial DLAT 0.0073
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.0071
484 Tyrosine-protein kinase ABL2 ABL2 0.0069
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0069
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.0069
686 Aldo-keto reductase family 1 member C2 AKR1C2 0.0067
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0067
57 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I HSD3B1 0.0067
543 Penicillin-binding protein 1B mrcB 0.0067
6186 Penicillin-binding protein 1B ponB 0.0067
6822 Penicillin-binding protein 1b pbp1b 0.0067
6844 Penicillin-binding protein 1b pbp1b 0.0067
319 Opioid receptor, sigma 1 OPRS1 0.0066
594 Thyroxine-binding globulin SERPINA7 0.0066
645 Penicillin-binding protein 1A mrcA 0.0065
5805 Penicillin-binding protein 1A ponA 0.0065
6185 Penicillin-binding protein 1A mrcA 0.0065
6799 Penicillin-binding protein 1A pbpA 0.0065
3014 Ribonuclease UK114 HRSP12 0.0064
5428 Replication protein repA 0.0064
3617 Non-heme chloroperoxidase cpo 0.0064
5426 Non-heme chloroperoxidase cpo 0.0064
5427 Hydroxyquinol 1,2-dioxygenase chqB 0.0064
3718 Hydrogen peroxide-inducible genes activator oxyR 0.0064
3018 HTH-type transcriptional regulator malT malT 0.0064
279 Tyrosinase TYR 0.0064
4484 2,5-diketo-D-gluconic acid reductase A dkgA 0.0062
3087 Nicotinate-nucleotide adenylyltransferase nadD 0.0062
4469 Nicotinate-nucleotide adenylyltransferase nadD 0.0062
4486 Phenol 2-hydroxylase component B pheA2 0.0062
4477 Dihydrolipoyl dehydrogenase lpdV 0.0062
5077 Dihydrolipoyl dehydrogenase Not Available 0.0062
5117 Dihydrolipoyl dehydrogenase lpd 0.0062
4439 Ferredoxin reductase bphA4 0.0062
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0062
3598 dTDP-4-dehydrorhamnose reductase rfbD 0.0062
4427 TDP-glucose-4,6-dehydratase desIV 0.0062
3177 dTDP-glucose 4,6-dehydratase rfbB 0.0062
4499 dTDP-glucose 4,6-dehydratase rmlB 0.0062
6021 Adenosine kinase ADK 0.0062
4482 UDP-galactose 4-epimerase galE 0.0061
4503 NADPH-flavin oxidoreductase frp 0.0061
2967 CDP-paratose 2-epimerase rfbE 0.0061
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0061
3081 3-dehydroquinate synthase aroB 0.0061
2507 Diphtheria toxin Not Available 0.0061
654 Flavin reductase BLVRB 0.0061
758 Thyroid hormone receptor alpha THRA 0.0061
2336 2,3-diketo-L-gulonate reductase dlgD 0.0061
2538 6-phospho-beta-glucosidase bglT bglT 0.0061
2393 Maltose-6'-phosphate glucosidase glvA 0.0061
2591 Urocanate hydratase hutU 0.0061
4496 C-terminal-binding protein 1 CTBP1 0.0061
2424 L-lactate dehydrogenase ldh 0.0061
2641 L-lactate dehydrogenase Not Available 0.0061
4437 L-lactate dehydrogenase ldh 0.0061
4442 L-lactate dehydrogenase ldh 0.0061
3615 Dihydrodipicolinate reductase dapB 0.006
3618 Dihydrodipicolinate reductase dapB 0.006
4462 Dihydrodipicolinate reductase dapB 0.006
3401 D-2-hydroxyisocaproate dehydrogenase Not Available 0.006
4509 Acetoin(diacetyl) reductase budC 0.006
3671 7-alpha-hydroxysteroid dehydrogenase hdhA 0.006
2831 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase Not Available 0.006
3059 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase fabG3 0.006
6698 Dehydrogenase/reductase SDR family member 4-like 2 DHRS4L2 0.006
1199 GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1 ART1 0.006
4450 Iota toxin component Ia Not Available 0.006
4498 Ornithine cyclodeaminase PP3533 0.006
2018 Deoxyhypusine synthase DHPS 0.006
661 ADP/ATP translocase 1 SLC25A4 0.006
2881 Gamma-aminobutyraldehyde dehydrogenase prr 0.006
4476 Mannitol dehydrogenase mtlD 0.0059
252 Tryptophanyl-tRNA synthetase, cytoplasmic WARS 0.0059
63 Malate dehydrogenase mdh 0.0059
2329 Malate dehydrogenase mdh 0.0059
3445 Malate dehydrogenase mdh 0.0059
4420 Malate dehydrogenase mdh 0.0059
4438 Malate dehydrogenase mdh 0.0059
765 Indoleamine 2,3-dioxygenase IDO1 0.0059
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0058
6837 Serine/threonine-protein kinase 17B STK17B 0.0057
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.0057
2452 Tryptophanyl-tRNA synthetase trpS 0.0056
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0056
380 Cytochrome P450 17A1 CYP17A1 0.0055
2958 Probable tautomerase ydcE pptA 0.0055
4504 WbpP Not Available 0.0055
3296 Nicotinamide mononucleotide adenylyltransferase 1 NMNAT1 0.0055
4318 Siroheme synthase cysG 0.0055
2573 Cocaine esterase cocE 0.0055
7263 Cocaine esterase Not Available 0.0055
4440 NADH peroxidase npr 0.0055
134 Tryptophan 5-hydroxylase 1 TPH1 0.0055
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0055
3367 GDP-mannose 6-dehydrogenase algD 0.0055
2936 Oxygen-insensitive NAD(P)H nitroreductase nfnB 0.0054
5184 Oxygen-insensitive NAD(P)H nitroreductase nfnB 0.0054
3603 Chlorocatechol 1,2-dioxygenase clcA 0.0054
3115 Ras-related protein Rab-9 RAB9A 0.0054
4343 Alpha-glucosidase aglA 0.0054
346 Thyroid hormone receptor beta-1 THRB 0.0054
6012 Tryptophan 2,3-dioxygenase TDO2 0.0053
327 Glutathione reductase gor 0.0053
5110 Glutathione reductase GR2 0.0053
3736 Glyceraldehyde-3-phosphate dehydrogenase A gapA 0.0053
2799 Glyceraldehyde-3-phosphate dehydrogenase, glycosomal Not Available 0.0053
2617 Nitric oxide synthase oxygenase nos 0.0052
2701 Nitric oxide synthase oxygenase nos 0.0052
834 Arginase-2, mitochondrial ARG2 0.0051
3333 Nicotinamide mononucleotide adenylyltransferase 3 NMNAT3 0.0051
2434 NH(3)-dependent NAD(+) synthetase nadE 0.0051
2910 NH(3)-dependent NAD(+) synthetase nadE 0.0051
3217 NH(3)-dependent NAD(+) synthetase nadE 0.0051
3070 Adenosylhomocysteinase AHCY 0.005
4424 Adenosylhomocysteinase PFE1050w 0.005
6278 Adenosylhomocysteinase ahcY 0.005
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.005
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.005
5325 2,4-dienoyl-CoA reductase, mitochondrial DECR1 0.005
577 Argininosuccinate lyase ASL 0.0049
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0049
3191 Histidinol dehydrogenase hisD 0.0049
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0048
6599 HTH-type transcriptional regulator ttgR ttgR 0.0046
1119 Peroxiredoxin-5, mitochondrial PRDX5 0.0046
822 Aldose reductase AKR1B1 0.0045
2286 Isocitrate dehydrogenase [NADP] icd 0.0045
2302 Isocitrate dehydrogenase [NADP] icd 0.0045
2771 Isocitrate dehydrogenase [NADP] icd 0.0045
590 5-hydroxytryptamine 2C receptor HTR2C 0.0044
4491 DNA ligase, NAD-dependent ligA 0.0044
2762 UDP-glucose 4-epimerase GALE 0.0044
3461 UDP-glucose 4-epimerase galE 0.0044
2599 Tyrosine-protein kinase HCK HCK 0.0044
4674 2-hydroxy-6-oxo-7-methylocta-2,4-dienoate hydrolase cumD 0.0043
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.0042
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.0042
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.0042
2693 Heat-labile enterotoxin B chain eltB 0.0042
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0041
373 Transthyretin TTR 0.004
5304 UPF0166 protein TM_0021 TM_0021 0.0038
5314 UPF0079 ATP-binding protein HI0065 HI_0065 0.0038
5293 Shikimate kinase 2 aroL 0.0038
5288 Shikimate kinase aroK 0.0038
5287 Signaling protein Not Available 0.0038
5292 Putative partitioning protein TT_C1605 0.0038
5266 Activator of hgdC 0.0038
3199 Phosphopantetheine adenylyltransferase coaD 0.0038
3543 Phosphopantetheine adenylyltransferase coaD 0.0038
3567 Phosphopantetheine adenylyltransferase coaD 0.0038
5289 Phosphopantetheine adenylyltransferase coaD 0.0038
2874 Nitrogenase iron protein 1 nifH1 0.0038
5283 D-alanine--D-alanine ligase B ddlB 0.0038
5281 Plasmid segregation protein parM parM 0.0038
5305 Phosphoribosylaminoimidazole carboxylase ATPase subunit purK 0.0038
5299 D-alanine--D-alanine ligase ddl 0.0038
6598 D-alanine--D-alanine ligase ddl 0.0038
5276 Chromosomal replication initiator protein dnaA dnaA 0.0038
5259 Transcriptional regulator ntrC1 0.0038
6699 Transcriptional regulator Cgl2612 0.0038
5290 ATP-dependent hsl protease ATP-binding subunit hslU hslU 0.0038
5638 ATP-dependent hsl protease ATP-binding subunit hslU hslU 0.0038
5270 ATP-dependent Clp protease ATP-binding subunit clpX clpX 0.0038
5275 Multidrug resistance ABC transporter ATP-binding and permease protein lmrA 0.0038
5291 Glycogen synthase 1 glgA1 0.0038
4346 Polynucleotide kinase pseT 0.0038
5264 DNA replication protein REP 0.0038
4794 Phosphoenolpyruvate carboxykinase [ATP] pckA 0.0038
5308 Preprotein translocase secA 1 subunit secA1 0.0038
5285 Kinesin heavy chain KIF5B 0.0038
5315 Chaperone protein htpG htpG 0.0038
1549 Heat shock 70 kDa protein 1 HSPA1A 0.0038
5284 Large T antigen Not Available 0.0038
3777 ATP-dependent Clp protease ATP-binding subunit clpA clpA 0.0038
5277 Preprotein translocase subunit secA secA 0.0038
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.0036
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0036
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0036
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0036
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0036
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.0035
6218 Pannexin-1 PANX1 0.0034
1517 Beta-3 adrenergic receptor ADRB3 0.0034
3811 Cytochrome P450 19A1 CYP19A1 0.0033
163 D(1B) dopamine receptor DRD5 0.0032
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0031
4837 Cag-alfa cag-alfa 0.0031
4839 DNA polymerase III subunit tau dnaX 0.0031
4838 PMS1 protein homolog 2 PMS2 0.0031
3390 Aminoglycoside 3'-phosphotransferase aphA 0.0031
6029 Aminoglycoside 3'-phosphotransferase aphA1 0.0031
5302 TrwB trwB 0.0031
5646 Galactokinase GALK1 0.0031
5265 FtsH ftsH 0.0031
4106 Guanylate kinase GUK1 0.0031
4516 Guanylate kinase gmk 0.0031
6277 Heat shock cognate 71 kDa protein HSPA8 0.0031
5189 Trimethylamine dehydrogenase tmd 0.003
4774 NTPase P4 Not Available 0.003
3175 Glutamate--cysteine ligase gshA 0.003
3426 Glutamine synthetase glnA 0.003
2270 Dephospho-CoA kinase coaE 0.003
432 D(4) dopamine receptor DRD4 0.003
2284 Adenylate kinase adk 0.003
2296 Adenylate kinase adk 0.003
2311 Adenylate kinase adk 0.003
2312 Adenylate kinase Not Available 0.003
3470 Hypothetical protein MG245 homolog MPN_348 0.003
2751 Holliday junction ATP-dependent DNA helicase ruvB ruvB 0.003
4755 Holliday junction ATP-dependent DNA helicase ruvB ruvB 0.003
5295 2-keto-3-deoxy-gluconate kinase TT_P0036 0.003
5300 Antigen peptide transporter 1 TAP1 0.0029
7 Nitric oxide synthase, inducible NOS2 0.0029
291 Nitric-oxide synthase, endothelial NOS3 0.0029
5312 Kinesin-like protein KIF1A KIF1A 0.0027
2390 Nonsecretory ribonuclease RNASE2 0.0027
2282 Protein recA recA 0.0027
2315 Protein recA recA 0.0027
2332 Protein recA recA 0.0027
5263 Protein recA recA 0.0027
2922 Glycerol kinase glpK 0.0027
5271 Focal adhesion kinase 1 PTK2 0.0027
408 Riboflavin kinase RFK 0.0027
789 Alpha-1D adrenergic receptor ADRA1D 0.0026
1898 Cytochrome P450 1B1 CYP1B1 0.0025
2615 Chemotaxis protein cheA cheA 0.0025
4366 Riboflavin kinase/FMN adenylyltransferase TM_0857 0.0025
2892 Acetylglutamate kinase argB 0.0025
3550 Acetylglutamate kinase argB 0.0025
2371 Pantothenate kinase coaA 0.0025
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0025
1881 Hexokinase-1 HK1 0.0025
2950 Inositol-trisphosphate 3-kinase A ITPKA 0.0025
3669 Ribokinase rbsK 0.0025
6857 [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 2, mitochondrial PDK2 0.0025
6832 Serine/threonine-protein kinase SRPK2 SRPK2 0.0025
788 Creatine kinase M-type CKM 0.0024
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0024
629 Alpha-2B adrenergic receptor ADRA2B 0.0024
193 Beta-1 adrenergic receptor ADRB1 0.0024
2727 S-adenosylmethionine synthetase metK 0.0024
6390 Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 ATP2A1 0.0024
766 Beta-2 adrenergic receptor ADRB2 0.0023
632 Alpha-1B adrenergic receptor ADRA1B 0.0023
2697 Uridine-cytidine kinase 2 UCK2 0.0023
2817 Phosphoribosylglycinamide formyltransferase 2 purT 0.0023
2334 Dethiobiotin synthetase bioD 0.0023
6555 Dethiobiotin synthetase bioD 0.0023
48 Pyridoxal kinase PDXK 0.0022
61 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0022
2644 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0022
2710 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0022
702 UMP-CMP kinase CMPK1 0.0021
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0021
2511 MAP kinase-activated protein kinase 2 MAPKAPK2 0.0021
2317 UDP-N-acetylmuramoylalanine--D-glutamate ligase murD 0.0021
2091 Endoplasmin HSP90B1 0.0021
2251 Thymidylate kinase tmk 0.0021
2254 Thymidylate kinase DTYMK 0.0021
3522 Thymidylate kinase tmk 0.0021
6395 Myosin-14 MYH14 0.002
6137 Multidrug resistance-associated protein 6 ABCC6 0.002
1422 Serine/threonine-protein kinase 6 AURKA 0.002
504 Mast/stem cell growth factor receptor KIT 0.0019
3379 Kinesin-like protein KIF11 KIF11 0.0019
3456 Heat shock protein HSP 90-beta HSP90AB1 0.0019
6136 Multidrug resistance-associated protein 5 ABCC5 0.0019
3822 Actin, alpha skeletal muscle ACTA1 0.0018
509 Thymidine kinase TK 0.0018
570 Thymidine kinase TK 0.0018
2559 Thymidine kinase TK 0.0018
3430 Thymidine kinase tdk 0.0018
3518 Thymidine kinase TK 0.0018
5301 Thymidine kinase tdk 0.0018
5771 Thymidine kinase ORF36 0.0018
7009 Thymidine kinase ORF36 0.0018
4773 Deoxycytidine kinase DCK 0.0018
5294 Nucleoside diphosphate kinase A NME1 0.0018
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0015
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