DT-Web

DB04074 - Alpha-ketoisovalerate


Identification
Name Alpha-ketoisovalerate
Accession Number DB04074 (EXPT01974)
Type small molecule
Description Not Available
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 116.1152
Groups experimental
Monoisotopic Weight 116.047344122
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


3-methyl-2-oxobutanoate hydroxymethyltransferase
Name 3-methyl-2-oxobutanoate hydroxymethyltransferase
Gene Name panB
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.7551
Deacetoxycephalosporin C synthetase
Name Deacetoxycephalosporin C synthetase
Gene Name cefE
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 1.5859
2-isopropylmalate synthase
Name 2-isopropylmalate synthase
Gene Name leuA
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.755
Branched-chain-amino-acid aminotransferase, mitochondrial
Name Branched-chain-amino-acid aminotransferase, mitochondrial
Gene Name BCAT2
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.7176

Transporters


Monocarboxylate transporter 2
Name Monocarboxylate transporter 2
Gene Name SLC16A7
Actions inhibitor
References
  • Broer S, Broer A, Schneider HP, Stegen C, Halestrap AP, Deitmer JW: Characterization of the high-affinity monocarboxylate transporter MCT2 in Xenopus laevis oocytes. Biochem J. 1999 Aug 1;341 ( Pt 3):529-35. - Pubmed
DTHybrid score 0.9132
Monocarboxylate transporter 1
Name Monocarboxylate transporter 1
Gene Name SLC16A1
Actions inhibitor
References
  • Broer S, Schneider HP, Broer A, Rahman B, Hamprecht B, Deitmer JW: Characterization of the monocarboxylate transporter 1 expressed in Xenopus laevis oocytes by changes in cytosolic pH. Biochem J. 1998 Jul 1;333 ( Pt 1):167-74. - Pubmed
DTHybrid score 0.7953
Monocarboxylate transporter 4
Name Monocarboxylate transporter 4
Gene Name SLC16A3
Actions substrate
References
  • Manning Fox JE, Meredith D, Halestrap AP: Characterisation of human monocarboxylate transporter 4 substantiates its role in lactic acid efflux from skeletal muscle. J Physiol. 2000 Dec 1;529 Pt 2:285-93. - Pubmed
DTHybrid score 0.9013

Predictions


Id Partner name Gene Name Score
3184 3-methyl-2-oxobutanoate hydroxymethyltransferase panB 0.7551
3401 D-2-hydroxyisocaproate dehydrogenase Not Available 0.3079
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0861
6151 Monocarboxylate transporter 10 SLC16A10 0.0822
5650 NimA-related protein DR_0842 0.0739
3254 Bifunctional protein putA [Includes: Proline dehydrogenase putA 0.0584
2293 Cyclomaltodextrin glucanotransferase Not Available 0.0568
2508 Cyclomaltodextrin glucanotransferase cgt 0.0568
2523 Cyclomaltodextrin glucanotransferase cgt 0.0568
3207 Cyclomaltodextrin glucanotransferase amyA 0.0568
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0551
574 Branched-chain-amino-acid aminotransferase, cytosolic BCAT1 0.0544
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0525
3205 Isocitrate lyase icl 0.0466
3078 Regulator of ribonuclease activity A Rv3853 0.0466
4132 Chloride channel protein ClC-Ka CLCNKA 0.044
199 Monocarboxylate transporter 8 SLC16A2 0.0401
701 Isoleucine-tRNA synthetase IARS 0.038
4080 Isoleucyl-tRNA synthetase, mitochondrial IARS2 0.0379
546 Isoleucyl-tRNA synthetase, cytoplasmic IARS 0.0379
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0352
2248 Malate synthase G glcB 0.0335
3190 Malate synthase G glcB 0.0335
501 Leucine carboxyl methyltransferase 1 LCMT1 0.033
675 Leucine carboxyl methyltransferase 2 LCMT2 0.0329
846 Leucyl-tRNA synthetase, cytoplasmic LARS 0.0329
227 Probable leucyl-tRNA synthetase, mitochondrial LARS2 0.0329
6826 Bacilysin biosynthesis protein bacB bacB 0.0328
6827 Probable chorismate mutase pheA 0.0327
6508 Putative uncharacterized protein srtB 0.0327
6543 Putative uncharacterized protein tcp14 0.0327
6615 Putative uncharacterized protein MT0785 0.0327
6623 Putative uncharacterized protein Not Available 0.0327
6806 Putative uncharacterized protein AGR_C_2535 0.0327
6813 Putative uncharacterized protein SAV4671 0.0327
6815 Putative uncharacterized protein AFE_1514 0.0327
6819 Putative uncharacterized protein RUMGNA_03254 0.0327
6825 Putative uncharacterized protein CV_3270 0.0327
397 Monocarboxylate transporter 3 SLC16A8 0.0303
2424 L-lactate dehydrogenase ldh 0.03
2641 L-lactate dehydrogenase Not Available 0.03
4437 L-lactate dehydrogenase ldh 0.03
4442 L-lactate dehydrogenase ldh 0.03
126 D-lactate dehydrogenase dld 0.03
3545 D-lactate dehydrogenase Not Available 0.03
4510 D-lactate dehydrogenase ldhA 0.03
195 Monocarboxylate transporter 7 SLC16A6 0.0299
429 Monocarboxylate transporter 6 SLC16A5 0.0299
218 Monocarboxylate transporter 5 SLC16A4 0.0298
860 Nicotinamide N-methyltransferase NNMT 0.0298
583 Nicotinate-nucleotide pyrophosphorylase [carboxylating] QPRT 0.0298
2442 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0298
2459 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0298
928 Nicotinic acid receptor 2 GPR109B 0.0297
699 Nicotinic acid receptor 1 GPR109A 0.0297
2744 D-alanine aminotransferase dat 0.0291
5607 Indole-3-pyruvate decarboxylase ipdC 0.0284
6657 Indole-3-pyruvate decarboxylase ipdC 0.0284
6616 L-phenylalanine dehydrogenase pdh 0.0284
52 Pyruvate kinase isozymes R/L PKLR 0.0272
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.027
6500 Phospholipase A2 PLA2G1B 0.027
118 Organic cation/carnitine transporter 2 SLC22A5 0.0265
3178 Formate acetyltransferase 1 pflB 0.026
1729 Solute carrier family 22 member 6 SLC22A6 0.0256
2746 4-aminobutyrate aminotransferase gabT 0.0255
2749 UDP-4-amino-4-deoxy-L-arabinose--oxoglutarate aminotransferase arnB 0.0251
2842 Glutamate-1-semialdehyde 2,1-aminomutase hemL 0.0251
2249 Aspartate aminotransferase aspC 0.025
2671 Aspartate aminotransferase aspC 0.025
5490 Aspartate aminotransferase Not Available 0.025
771 Pyruvate carboxylase, mitochondrial PC 0.0246
98 Pyruvate kinase isozymes M1/M2 PKM2 0.0244
114 Alanine--glyoxylate aminotransferase 2, mitochondrial AGXT2 0.0241
110 Pyruvate dehydrogenase E1 component subunit beta, mitochondrial PDHB 0.0237
2546 Histidinol-phosphate aminotransferase hisC 0.0235
2698 Histidinol-phosphate aminotransferase hisC 0.0235
77 L-lactate dehydrogenase B chain LDHB 0.0232
723 Cytosolic phospholipase A2 PLA2G4A 0.0229
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0227
301 Kynurenine--oxoglutarate transaminase 1 CCBL1 0.0225
473 L-lactate dehydrogenase A chain LDHA 0.0224
20 Prostaglandin G/H synthase 1 PTGS1 0.0207
6268 Hydroxyacid oxidase 1 HAO1 0.0206
894 Alanine racemase alr 0.0195
2453 Alanine racemase alr 0.0195
6837 Serine/threonine-protein kinase 17B STK17B 0.0183
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.0183
6142 Solute carrier family 22 member 8 SLC22A8 0.0182
290 Prostaglandin G/H synthase 2 PTGS2 0.018
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0172
862 Multidrug resistance-associated protein 1 ABCC1 0.0165
6143 Solute carrier family 22 member 7 SLC22A7 0.0162
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.0159
1588 Multidrug resistance protein 1 ABCB1 0.0156
1024 Solute carrier family 22 member 11 SLC22A11 0.0149
338 DNA polymerase UL30 0.0149
379 DNA polymerase UL54 0.0149
697 DNA polymerase ORF28 0.0149
2482 DNA polymerase 43 0.0149
4104 DNA polymerase BALF5 0.0149
6599 HTH-type transcriptional regulator ttgR ttgR 0.0147
587 Serum albumin ALB 0.0143
2599 Tyrosine-protein kinase HCK HCK 0.0139
6149 Solute carrier family 22 member 10 SLC22A10 0.0135
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.0133
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.0133
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.0133
4119 Cytochrome P450 2D6 CYP2D6 0.0121
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.012
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0117
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.0116
4924 Cytochrome P450 2C8 CYP2C8 0.0113
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.0111
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0106
2164 Multidrug resistance-associated protein 4 ABCC4 0.0104
6218 Pannexin-1 PANX1 0.0101
4757 Cytochrome P450 2C9 CYP2C9 0.0099
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0098
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0094
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0083
6145 Solute carrier family 22 member 1 SLC22A1 0.0082
6141 Sodium/bile acid cotransporter SLC10A1 0.0081
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0081
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0079
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0078
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0076
3895 Kynurenine--oxoglutarate transaminase 3 CCBL2 0.0075
665 Phosphoserine aminotransferase PSAT1 0.0075
4652 Phosphoserine aminotransferase serC 0.0075
801 Kynurenine/alpha-aminoadipate aminotransferase mitochondrial AADAT 0.0075
420 Glutamate decarboxylase 1 GAD1 0.0075
3900 Glutamate decarboxylase 1 GAD1 0.0075
6144 Solute carrier family 22 member 2 SLC22A2 0.0068
3877 Growth-inhibiting protein 18 GIG18 0.0068
4512 Cytochrome P450 3A4 CYP3A4 0.0068
426 Aspartate aminotransferase, mitochondrial GOT2 0.0067
543 Penicillin-binding protein 1B mrcB 0.0067
6186 Penicillin-binding protein 1B ponB 0.0067
6822 Penicillin-binding protein 1b pbp1b 0.0067
6844 Penicillin-binding protein 1b pbp1b 0.0067
914 Formimidoyltransferase-cyclodeaminase FTCD 0.0065
645 Penicillin-binding protein 1A mrcA 0.0065
5805 Penicillin-binding protein 1A ponA 0.0065
6185 Penicillin-binding protein 1A mrcA 0.0065
6799 Penicillin-binding protein 1A pbpA 0.0065
3014 Ribonuclease UK114 HRSP12 0.0064
5428 Replication protein repA 0.0064
3617 Non-heme chloroperoxidase cpo 0.0064
5426 Non-heme chloroperoxidase cpo 0.0064
5427 Hydroxyquinol 1,2-dioxygenase chqB 0.0064
3718 Hydrogen peroxide-inducible genes activator oxyR 0.0064
3018 HTH-type transcriptional regulator malT malT 0.0064
159 Penicillin-binding protein 2B penA 0.0064
6121 Penicillin-binding protein 2B penA 0.0064
763 Tyrosine aminotransferase TAT 0.0064
5493 Tyrosine aminotransferase Not Available 0.0064
3904 Alanine aminotransferase 2 GPT2 0.0063
735 Alanine aminotransferase 1 GPT 0.0063
586 Aspartate aminotransferase, cytoplasmic GOT1 0.0063
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0062
6137 Multidrug resistance-associated protein 6 ABCC6 0.0059
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0059
33 Cystine/glutamate transporter SLC7A11 0.0057
6136 Multidrug resistance-associated protein 5 ABCC5 0.0055
2958 Probable tautomerase ydcE pptA 0.0055
2573 Cocaine esterase cocE 0.0055
7263 Cocaine esterase Not Available 0.0055
2936 Oxygen-insensitive NAD(P)H nitroreductase nfnB 0.0054
5184 Oxygen-insensitive NAD(P)H nitroreductase nfnB 0.0054
3603 Chlorocatechol 1,2-dioxygenase clcA 0.0054
3115 Ras-related protein Rab-9 RAB9A 0.0054
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0053
4024 Mitochondrial glutamate carrier 2 SLC25A18 0.005
4025 Mitochondrial glutamate carrier 1 SLC25A22 0.005
664 Glutamate decarboxylase 2 GAD2 0.005
3890 Glutamate decarboxylase 2 GAD2 0.005
4026 Aspartyl aminopeptidase DNPEP 0.005
1912 Excitatory amino acid transporter 1 SLC1A3 0.005
4021 Probable glutamyl-tRNA synthetase, mitochondrial EARS2 0.005
4019 Excitatory amino acid transporter 4 SLC1A6 0.005
4022 Glutamate--ammonia ligase domain-containing protein 1 LGSN 0.005
4023 N-acetylglutamate synthase, mitochondrial NAGS 0.005
4016 Excitatory amino acid transporter 5 SLC1A7 0.005
1047 Excitatory amino acid transporter 2 SLC1A2 0.005
919 Glutamate receptor, ionotropic kainate 4 GRIK4 0.005
922 Glutamate receptor 4 GRIA4 0.005
926 Metabotropic glutamate receptor 7 GRM7 0.005
915 Delta 1-pyrroline-5-carboxylate synthetase ALDH18A1 0.005
927 Metabotropic glutamate receptor 8 GRM8 0.005
4020 Glutamyl aminopeptidase ENPEP 0.005
925 Metabotropic glutamate receptor 4 GRM4 0.005
924 Glutamate receptor, ionotropic kainate 3 GRIK3 0.005
920 Glutamate receptor, ionotropic kainate 5 GRIK5 0.005
4027 Glutamate receptor delta-1 subunit GRID1 0.005
4018 Glutamate receptor delta-2 subunit GRID2 0.005
4017 5-oxoprolinase OPLAH 0.005
4118 Cytochrome P450 3A5 CYP3A5 0.0049
4037 Hypothetical protein GPX1 0.0047
4297 Hypothetical protein SP_1951 0.0047
4521 Hypothetical protein BC_2969 0.0047
4540 Hypothetical protein TM_1070 0.0047
4555 Hypothetical protein MT1739 0.0047
4569 Hypothetical protein mshD 0.0047
4578 Hypothetical protein PA3270 0.0047
4747 Hypothetical protein PA3967 0.0047
5177 Hypothetical protein TM_0096 0.0047
5194 Hypothetical protein PA1204 0.0047
5240 Hypothetical protein Rv2991 0.0047
5370 Hypothetical protein TM_1158 0.0047
5710 Hypothetical protein Tb927.5.1360 0.0047
4545 Molybdopterin-converting factor subunit 2 moaE 0.0047
4527 Putative hydrolase ycdX ycdX 0.0047
4106 Guanylate kinase GUK1 0.0047
4516 Guanylate kinase gmk 0.0047
4538 Hypothetical protein VC1899 VC_1899 0.0047
4536 Transcriptional regulator, IclR family TM_0065 0.0047
2501 Protein ygbM ygbM 0.0047
4514 Citrate lyase beta subunit-like protein citE 0.0047
4781 Citrate lyase beta subunit-like protein DR_1240 0.0047
4524 Mannose-6-phosphate isomerase yvyI 0.0047
4522 Arginine N-succinyltransferase subunit alpha astA 0.0047
4547 Iron binding protein FbpA fbpA 0.0047
4529 Oxalate decarboxylase oxdC oxdC 0.0047
4546 Aminotransferase, putative TM_1131 0.0047
658 Para-aminobenzoate synthase component 1 pabB 0.0047
4526 Oligopeptide ABC transporter, periplasmic oligopeptide-binding protein TM_1223 0.0047
4535 Glutaconyl-CoA decarboxylase subunit alpha gcdA 0.0047
4548 Gyrase B gyrB 0.0047
4515 Peripheral plasma membrane protein CASK CASK 0.0047
1119 Peroxiredoxin-5, mitochondrial PRDX5 0.0046
6016 Cytochrome P450 2C19 CYP2C19 0.0045
625 Glutamate carboxypeptidase 2 FOLH1 0.0044
830 Glutamate dehydrogenase 2, mitochondrial GLUD2 0.0044
668 Glutamate--cysteine ligase regulatory subunit GCLM 0.0043
4674 2-hydroxy-6-oxo-7-methylocta-2,4-dienoate hydrolase cumD 0.0043
3984 Probable glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial PET112L 0.0043
355 GMP synthase [glutamine-hydrolyzing] GMPS 0.0043
4353 GMP synthase [glutamine-hydrolyzing] guaA 0.0043
3991 Glutamine-dependent NAD(+) synthetase NADSYN1 0.0043
5 Glutaminase liver isoform, mitochondrial GLS2 0.0043
917 Glutaminase kidney isoform, mitochondrial GLS 0.0043
3982 Phosphoribosylformylglycinamidine synthase PFAS 0.0043
5261 Phosphoribosylformylglycinamidine synthase purL 0.0043
4496 C-terminal-binding protein 1 CTBP1 0.0043
2693 Heat-labile enterotoxin B chain eltB 0.0042
4532 Gephyrin GPHN 0.0041
6645 D-amino-acid oxidase DAO 0.0041
56 Delta-aminolevulinic acid dehydratase ALAD 0.0041
2356 Delta-aminolevulinic acid dehydratase hemB 0.0041
3613 Delta-aminolevulinic acid dehydratase hemB 0.0041
3674 Delta-aminolevulinic acid dehydratase hemB 0.0041
4533 Glyoxalase family protein BC_1747 0.0041
3237 Beta-lactamase OXA-2 bla 0.0041
4542 Glutaminase 1 glsA1 0.0041
4544 Glutaminase 1 glsA1 0.0041
2929 (S)-2-haloacid dehalogenase dhlB 0.0041
2995 (S)-2-haloacid dehalogenase Not Available 0.0041
4528 Phenazine biosynthesis protein PhzD phzD1 0.0041
3759 Glutathione S-transferase gst 0.004
4541 Glutathione S-transferase GST 0.004
3261 Signal recognition particle protein ffh 0.004
4517 Probable butyrate kinase 2 buk2 0.004
916 Metabotropic glutamate receptor 1 GRM1 0.004
776 Bile salt export pump ABCB11 0.004
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.004
923 Glutamate receptor 3 GRIA3 0.0039
2230 Catalase CAT 0.0039
3249 Catalase katA 0.0039
3625 Catalase katA 0.0039
4539 Catalase katA 0.0039
4941 Catalase katB 0.0039
83 Alpha-aminoadipic semialdehyde synthase, mitochondrial AASS 0.0039
1671 Excitatory amino acid transporter 3 SLC1A1 0.0039
201 Glutamate dehydrogenase 1, mitochondrial GLUD1 0.0038
186 Glutamate--cysteine ligase catalytic subunit GCLC 0.0038
210 Bifunctional aminoacyl-tRNA synthetase [Includes: Glutamyl-tRNA synthetase EPRS 0.0038
448 Vitamin K-dependent gamma-carboxylase GGCX 0.0038
3583 6-phosphogluconolactonase pgl 0.0037
3467 Methylglyoxal synthase mgsA 0.0037
2775 Dihydroorotate dehydrogenase pyrD 0.0037
4531 Putative ketoacyl reductase actIII 0.0037
6148 Multidrug resistance-associated protein 7 ABCC10 0.0036
306 Pyridoxal phosphate phosphatase PDXP 0.0036
3881 Selenocysteine lyase variant Not Available 0.0036
3887 Phosphorylase PYGB 0.0036
3908 P-selectin cytoplasmic tail-associated protein pcap 0.0036
3915 Cysteine sulfinic acid decarboxylase-related protein 1 CSAD 0.0036
3914 Alanine-glyoxylate aminotransferase homolog TLH6 0.0036
3911 Uncharacterized protein C20orf38 SPTLC3 0.0036
3906 Serine dehydratase-like SDSL 0.0036
3896 CDNA FLJ46802 fis, clone TRACH3032150, moderately similar to Cysteine sulfinic acid decarboxylase GADL1 0.0036
3891 Putative L-Dopa decarboxylase DDC 0.0036
3909 Hepatic peroxysomal alanine:glyoxylate aminotransferase Not Available 0.0036
3878 GAD1 protein GAD1 0.0036
3893 DDC protein DDC 0.0036
3880 Serine hydroxymethyltransferase 1 Not Available 0.0036
3883 Ornithine aminotransferase variant Not Available 0.0036
3910 O-phosphoseryl-tRNA(Sec) selenium transferase SEPSECS 0.0036
855 Sphingosine-1-phosphate lyase 1 SGPL1 0.0036
3903 Aminolevulinate, delta-, synthase 2 ALAS2 0.0036
3886 Migration-inducing protein 4 ALAS1 0.0036
3894 KIAA0251 protein PDXDC1 0.0036
3875 Glycogen phosphorylase, brain form PYGB 0.0036
3882 Brain glycogen phosphorylase variant Not Available 0.0036
3905 Molybdenum cofactor sulfurase MOCOS 0.0036
1039 Histone deacetylase 9 HDAC9 0.0036
2525 3-phosphoshikimate 1-carboxyvinyltransferase aroA 0.0035
3201 3-phosphoshikimate 1-carboxyvinyltransferase aroA 0.0035
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0035
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0035
242 Asparagine synthetase [glutamine-hydrolyzing] ASNS 0.0034
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0034
3587 Gastrotropin FABP6 0.0034
2688 Peptide deformylase def 0.0033
2708 Peptide deformylase def 0.0033
3004 Peptide deformylase def 0.0033
4337 Peptide deformylase def 0.0033
4338 Peptide deformylase def 0.0033
5368 Peptide deformylase def 0.0033
5371 Peptide deformylase def 0.0033
6375 Peptide deformylase def 0.0033
6378 Peptide deformylase def 0.0033
6379 Peptide deformylase def 0.0033
6776 Peptide deformylase def 0.0033
6900 Peptide deformylase def 0.0033
4534 Cytohesin-2 CYTH2 0.0033
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0033
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0033
2548 Subtilisin Carlsberg apr 0.0032
4269 Hypoxanthine-guanine phosphoribosyltransferase, putative HGPRTase 0.0032
3426 Glutamine synthetase glnA 0.0032
3987 Glutamine synthetase GLUL 0.0032
705 Glutamate receptor 1 GRIA1 0.0032
3874 Proline synthetase co-transcribed bacterial homolog protein PROSC 0.0031
534 Threonine synthase-like 1 THNSL1 0.0031
3899 Alanine--glyoxylate aminotransferase 2-like 2 AGXT2L2 0.0031
184 L-serine dehydratase SDS 0.0031
727 Serine palmitoyltransferase 2 SPTLC2 0.0031
431 Serine racemase SRR 0.0031
833 Organic cation/carnitine transporter 1 SLC22A4 0.0031
491 Serine palmitoyltransferase 1 SPTLC1 0.0031
89 Cysteine sulfinic acid decarboxylase CSAD 0.0031
499 Arginine decarboxylase ADC 0.0031
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0031
575 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial GCAT 0.0031
455 5-aminolevulinate synthase, nonspecific, mitochondrial ALAS1 0.0031
681 Glycine dehydrogenase [decarboxylating], mitochondrial GLDC 0.0031
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0031
3 Histidine decarboxylase HDC 0.0031
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.003
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.003
5818 Folate receptor alpha FOLR1 0.003
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.003
435 Kynureninase KYNU 0.003
4654 Kynureninase kynU 0.003
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.003
472 Ornithine aminotransferase, mitochondrial OAT 0.0029
3913 Glutamic acid decarboxylase GAD65 0.0029
203 Pyridoxine-5'-phosphate oxidase PNPO 0.0029
169 Cysteine desulfurase, mitochondrial NFS1 0.0029
868 Cystathionine gamma-lyase CTH 0.0028
760 Fibroblast growth factor 1 FGF1 0.0027
3884 SHMT2 protein SHMT2 0.0027
3901 SHMT2 protein SHMT2 0.0027
3885 Hypothetical protein DKFZp686P09201 DKFZp686P09201 0.0027
3879 Serine hydroxymethyltransferase 2 Not Available 0.0027
321 Serine hydroxymethyltransferase, mitochondrial SHMT2 0.0027
810 Heme oxygenase 1 HMOX1 0.0027
3391 Heme oxygenase 1 pbsA1 0.0027
358 Cystathionine beta-synthase CBS 0.0027
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0027
3027 Streptavidin Not Available 0.0027
6167 Organic solute transporter subunit beta OSTB 0.0027
6166 Organic solute transporter subunit alpha OSTA 0.0027
293 Gamma-glutamyl hydrolase GGH 0.0026
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0026
349 Serine--pyruvate aminotransferase AGXT 0.0026
449 Ornithine decarboxylase ODC1 0.0026
367 Serine hydroxymethyltransferase, cytosolic SHMT1 0.0025
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0025
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0025
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0025
1650 Heme carrier protein 1 SLC46A1 0.0024
921 Glutamate receptor 2 GRIA2 0.0024
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0024
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0024
76 Nitric-oxide synthase, brain NOS1 0.0024
5682 Ribonuclease pancreatic RNASE1 0.0023
10 Glycogen phosphorylase, liver form PYGL 0.0023
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0022
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0022
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0022
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0022
6107 Cytochrome P450 3A7 CYP3A7 0.0021
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.002
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0019
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0019
3917 Methylenetetrahydrofolate reductase MTHFR 0.0019
24 Thymidylate synthase TMP1 0.0018
359 Thymidylate synthase TYMS 0.0018
2626 Thymidylate synthase thyA 0.0018
2729 Thymidylate synthase thyA 0.0018
5352 Thymidylate synthase THYA 0.0018
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0018
1152 Glycogen phosphorylase, muscle form PYGM 0.0018
365 Dihydrofolate reductase DHFR 0.0018
2381 Dihydrofolate reductase DFR1 0.0018
2833 Dihydrofolate reductase Not Available 0.0018
2931 Dihydrofolate reductase folA 0.0018
3544 Dihydrofolate reductase folA 0.0018
3682 Dihydrofolate reductase folA 0.0018
6642 Dihydrofolate reductase folA 0.0018
6756 Dihydrofolate reductase dfrA 0.0018
6106 Cytochrome P450 2C18 CYP2C18 0.0018
6020 Aldehyde oxidase AOX1 0.0018
357 Carbonic anhydrase 2 CA2 0.0017
5718 Cytochrome P450 2A6 CYP2A6 0.0015
6030 Cytochrome P450 2B6 CYP2B6 0.0013
4200 Cytochrome P450 1A2 CYP1A2 0.0012
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