DT-Web

DB00118 - S-Adenosylmethionine


Identification
Name S-Adenosylmethionine
Accession Number DB00118 (NUTR00052)
Type small molecule
Description Physiologic methyl radical donor involved in enzymatic transmethylation reactions and present in all living organisms. It possesses anti-inflammatory activity and has been used in treatment of chronic liver disease. (From Merck, 11th ed)
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 399.445
Groups approved
Monoisotopic Weight 399.145063566
Pharmacology
Indication S-Adenosylmethionine (SAMe) is used as a drug in Europe for the treatment of depression, liver disorders, fibromyalgia, and osteoarthritis. It has also been introduced into the United States market as a dietary supplement for the support of bone and joint health, as well as mood and emotional well being.
Mechanism of action S-Adenosylmethionine (SAMe) is a natural substance present in the cells of the body. It is a direct metabolite of the essential amino acid L-methionine. SAMe plays a crucial biochemical role in the body by donating a one-carbon methyl group in a process called transmethylation. SAMe, formed from the reaction of L-methionine and adenosine triphosphate catalyzed by the enzyme S-adenosylmethionine synthetase, is the methyl-group donor in the biosynthesis of both DNA and RNA nucleic acids, phospholipids, proteins, epinephrine, melatonin, creatine and other molecules.
Absorption S-Adenosylmethionine is absorbed from the small intestine following oral intake. As absorption is affected by food, it is best to take on an empty stomach. Bioavailability is low following oral intake.
Protein binding Not Available
Biotransformation Significant first-pass metabolism in the liver. Approximately 50% of S-Adenosylmethionine (SAMe) is metabolized in the liver. SAMe is metabolized to S-adenosylhomocysteine, which is then metabolized to homocysteine. Homocysteine can either be metabolized to cystathionine and then cysteine or to methionine. The cofactor in the metabolism of homocysteine to cysteine is vitamin B6. Cofactors for the metabolism of homocysteine to methionine are folic acid, vitamin B12 and betaine.
Route of elimination Not Available
Toxicity Irritating to mucus membranes and upper respiratory tract. Can cause CNS depression.
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Desvenlafaxine Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Ginkgo biloba Additive anticoagulant/antiplatelet effects may increase bleed risk. Concomitant therapy should be avoided.
Ketoprofen Increased risk of bleeding due to additive antiplatelet properties of the two agents. Concomitant therapy should be avoided or monitored carefully for bleeding, bruising and altered mental status, which may be caused by CNS bleeds.
Sulindac S-adenosylmethionine may enhance the anticoagulant effect of sulindac. Increased risk of bleeding, bruising and altered mental status due to CNS bleeds. Concomitant therapy should be avoided.
Tramadol Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Tranylcypromine Increased risk of serotonin syndrome. Use caution during concomitant therapy and monitor for symptoms of serotonin syndrome.
Trazodone Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Trimipramine Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Venlafaxine Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Warfarin Additive anticoagulant effects increase the risk of bleeding. Concomitant therapy should be avoided.
Zolmitriptan Use of two serotonin modulators, such as zolmitriptan and S-adenosylmethionine, increases the risk of serotonin syndrome. Consider alternate therapy or monitor for serotonin syndrome during concomitant therapy.
Food Interactions Not Available

Targets


Glycine N-methyltransferase
Name Glycine N-methyltransferase
Gene Name GNMT
Pharmacological action unknown
Actions cofactor
References
  • Rowling MJ, Schalinske KL: Retinoid compounds activate and induce hepatic glycine N-methyltransferase in rats. J Nutr. 2001 Jul;131(7):1914-7. - Pubmed
  • Luka Z, Cerone R, Phillips JA 3rd, Mudd HS, Wagner C: Mutations in human glycine N-methyltransferase give insights into its role in methionine metabolism. Hum Genet. 2002 Jan;110(1):68-74. Epub 2001 Dec 7. - Pubmed
  • Rowling MJ, McMullen MH, Chipman DC, Schalinske KL: Hepatic glycine N-methyltransferase is up-regulated by excess dietary methionine in rats. J Nutr. 2002 Sep;132(9):2545-50. - Pubmed
  • Moller MT, Samari HR, Fengsrud M, Stromhaug PE, oStvold AC, Seglen PO: Okadaic acid-induced, naringin-sensitive phosphorylation of glycine N-methyltransferase in isolated rat hepatocytes. Biochem J. 2003 Jul 15;373(Pt 2):505-13. - Pubmed
  • Uthus EO, Brown-Borg HM: Altered methionine metabolism in long living Ames dwarf mice. Exp Gerontol. 2003 May;38(5):491-8. - Pubmed
DTHybrid score 0.4176
S-adenosylmethionine decarboxylase proenzyme
Name S-adenosylmethionine decarboxylase proenzyme
Gene Name AMD1
Pharmacological action unknown
Actions cofactor
References
  • Dudkowska M, Stachurska A, Grzelakowska-Sztabert B, Manteuffel-Cymborowska M: Up-regulation of spermidine/spermine N1-acetyltransferase (SSAT) expression is a part of proliferative but not anabolic response of mouse kidney. Acta Biochim Pol. 2002;49(4):969-77. - Pubmed
  • Ndjonka D, Zou Y, Bi X, Woster P, Walter RD, Luersen K: The activator-binding site of Onchocerca volvulus S-adenosylmethionine decarboxylase, a potential drug target. Biol Chem. 2003 Aug;384(8):1195-201. - Pubmed
  • Notari S, Lucchi R, Traversa U, Fabbri E, Poli A: Reversible changes in goldfish brain polyamine concentrations and synthetic enzymes after cold exposure. Brain Res. 2004 May 1;1006(2):241-7. - Pubmed
  • Yerlikaya A, Stanley BA: Structural basis for the inactivation of AdoMetDC K12R mutant. Protein Pept Lett. 2006;13(3):313-7. - Pubmed
DTHybrid score 0.9651
S-adenosylmethionine synthetase isoform type-2
Name S-adenosylmethionine synthetase isoform type-2
Gene Name MAT2A
Pharmacological action unknown
Actions cofactor
References
  • Mudd SH, Cerone R, Schiaffino MC, Fantasia AR, Minniti G, Caruso U, Lorini R, Watkins D, Matiaszuk N, Rosenblatt DS, Schwahn B, Rozen R, LeGros L, Kotb M, Capdevila A, Luka Z, Finkelstein JD, Tangerman A, Stabler SP, Allen RH, Wagner C: Glycine N-methyltransferase deficiency: a novel inborn error causing persistent isolated hypermethioninaemia. J Inherit Metab Dis. 2001 Aug;24(4):448-64. - Pubmed
  • Farrar C, Clarke S: Altered levels of S-adenosylmethionine and S-adenosylhomocysteine in the brains of L-isoaspartyl (D-Aspartyl) O-methyltransferase-deficient mice. J Biol Chem. 2002 Aug 2;277(31):27856-63. Epub 2002 May 22. - Pubmed
  • Martinez-Chantar ML, Latasa MU, Varela-Rey M, Lu SC, Garcia-Trevijano ER, Mato JM, Avila MA: L-methionine availability regulates expression of the methionine adenosyltransferase 2A gene in human hepatocarcinoma cells: role of S-adenosylmethionine. J Biol Chem. 2003 May 30;278(22):19885-90. Epub 2003 Mar 26. - Pubmed
  • Martinez-Chantar ML, Garcia-Trevijano ER, Latasa MU, Martin-Duce A, Fortes P, Caballeria J, Avila MA, Mato JM: Methionine adenosyltransferase II beta subunit gene expression provides a proliferative advantage in human hepatoma. Gastroenterology. 2003 Apr;124(4):940-8. - Pubmed
DTHybrid score 0.5377
Cystathionine beta-synthase
Name Cystathionine beta-synthase
Gene Name CBS
Pharmacological action unknown
Actions activator
References
  • Janosik M, Kery V, Gaustadnes M, Maclean KN, Kraus JP: Regulation of human cystathionine beta-synthase by S-adenosyl-L-methionine: evidence for two catalytically active conformations involving an autoinhibitory domain in the C-terminal region. Biochemistry. 2001 Sep 4;40(35):10625-33. - Pubmed
  • Jacobs RL, Stead LM, Brosnan ME, Brosnan JT: Hyperglucagonemia in rats results in decreased plasma homocysteine and increased flux through the transsulfuration pathway in liver. J Biol Chem. 2001 Nov 23;276(47):43740-7. Epub 2001 Sep 14. - Pubmed
  • Choumenkovitch SF, Selhub J, Bagley PJ, Maeda N, Nadeau MR, Smith DE, Choi SW: In the cystathionine beta-synthase knockout mouse, elevations in total plasma homocysteine increase tissue S-adenosylhomocysteine, but responses of S-adenosylmethionine and DNA methylation are tissue specific. J Nutr. 2002 Aug;132(8):2157-60. - Pubmed
  • Evande R, Blom H, Boers GH, Banerjee R: Alleviation of intrasteric inhibition by the pathogenic activation domain mutation, D444N, in human cystathionine beta-synthase. Biochemistry. 2002 Oct 1;41(39):11832-7. - Pubmed
DTHybrid score 0.4333
S-adenosylmethionine synthetase isoform type-1
Name S-adenosylmethionine synthetase isoform type-1
Gene Name MAT1A
Pharmacological action unknown
Actions cofactor
References
  • Carretero MV, Latasa MU, Garcia-Trevijano ER, Corrales FJ, Wagner C, Mato JM, Avila MA: Inhibition of liver methionine adenosyltransferase gene expression by 3-methylcolanthrene: protective effect of S-adenosylmethionine. Biochem Pharmacol. 2001 May 1;61(9):1119-28. - Pubmed
  • Martinez-Chantar ML, Corrales FJ, Martinez-Cruz LA, Garcia-Trevijano ER, Huang ZZ, Chen L, Kanel G, Avila MA, Mato JM, Lu SC: Spontaneous oxidative stress and liver tumors in mice lacking methionine adenosyltransferase 1A. FASEB J. 2002 Aug;16(10):1292-4. Epub 2002 Jun 7. - Pubmed
  • Santamaria E, Avila MA, Latasa MU, Rubio A, Martin-Duce A, Lu SC, Mato JM, Corrales FJ: Functional proteomics of nonalcoholic steatohepatitis: mitochondrial proteins as targets of S-adenosylmethionine. Proc Natl Acad Sci U S A. 2003 Mar 18;100(6):3065-70. Epub 2003 Mar 11. - Pubmed
  • Martinez-Chantar ML, Latasa MU, Varela-Rey M, Lu SC, Garcia-Trevijano ER, Mato JM, Avila MA: L-methionine availability regulates expression of the methionine adenosyltransferase 2A gene in human hepatocarcinoma cells: role of S-adenosylmethionine. J Biol Chem. 2003 May 30;278(22):19885-90. Epub 2003 Mar 26. - Pubmed
  • Martinez-Chantar ML, Garcia-Trevijano ER, Latasa MU, Martin-Duce A, Fortes P, Caballeria J, Avila MA, Mato JM: Methionine adenosyltransferase II beta subunit gene expression provides a proliferative advantage in human hepatoma. Gastroenterology. 2003 Apr;124(4):940-8. - Pubmed
DTHybrid score 1.1752
Catechol O-methyltransferase
Name Catechol O-methyltransferase
Gene Name COMT
Pharmacological action unknown
Actions cofactor
References
  • Lee BW, Sun HG, Zang T, Kim BJ, Alfaro JF, Zhou ZS: Enzyme-catalyzed transfer of a ketone group from an S-adenosylmethionine analogue: a tool for the functional analysis of methyltransferases. J Am Chem Soc. 2010 Mar 24;132(11):3642-3. - Pubmed
  • Rutherford K, Le Trong I, Stenkamp RE, Parson WW: Crystal structures of human 108V and 108M catechol O-methyltransferase. J Mol Biol. 2008 Jun 27;380(1):120-30. Epub 2008 Apr 23. - Pubmed
DTHybrid score 1.0054

Enzymes


Cytochrome P450 2E1
Name Cytochrome P450 2E1
Gene Name CYP2E1
Actions inhibitor
References
  • Caro AA, Cederbaum AI: Inhibition of CYP2E1 catalytic activity in vitro by S-adenosyl-L-methionine. Biochem Pharmacol. 2005 Apr 1;69(7):1081-93. - Pubmed
  • Cederbaum AI: Hepatoprotective effects of S-adenosyl-L-methionine against alcohol- and cytochrome P450 2E1-induced liver injury. World J Gastroenterol. 2010 Mar 21;16(11):1366-76. - Pubmed
DTHybrid score 0.3168
Spermidine synthase
Name Spermidine synthase
Gene Name SRM
Actions substrate
References
  • Cyriac J, Haleem R, Cai X, Wang Z: Androgen regulation of spermidine synthase expression in the rat prostate. Prostate. 2002 Mar 1;50(4):252-61. - Pubmed
  • Dejima H, Kobayashi M, Takasaki H, Takeda N, Shirahata A, Samejima K: Synthetic decarboxylated S-adenosyl-L-methionine as a substrate for aminopropyl transferases. Biol Pharm Bull. 2003 Jul;26(7):1005-8. - Pubmed
  • Franceschetti M, Fornale S, Tassonia A, Zuccherelli K, Mayer MJ, Bagni N: Effects of spermidine synthase overexpression on polyamine biosynthetic pathway in tobacco plants. J Plant Physiol. 2004 Sep;161(9):989-1001. - Pubmed
DTHybrid score 0.5749

Predictions


Id Partner name Gene Name Score
3038 Spermidine synthase speE 0.5749
2429 Putrescine-binding periplasmic protein potF 0.1269
449 Ornithine decarboxylase ODC1 0.0806
317 Methionine-R-sulfoxide reductase SEPX1 0.0769
3921 Methionine adenosyltransferase 2 subunit beta MAT2B 0.0769
480 Methionine-R-sulfoxide reductase B2 MSRB2 0.0769
3996 Betaine--homocysteine S-methyltransferase 2 BHMT2 0.0768
600 Methionyl-tRNA synthetase, cytoplasmic MARS 0.0768
3995 Methionyl-tRNA synthetase, mitochondrial MARS2 0.0768
6151 Monocarboxylate transporter 10 SLC16A10 0.073
4757 Cytochrome P450 2C9 CYP2C9 0.0681
4512 Cytochrome P450 3A4 CYP3A4 0.0662
941 Betaine--homocysteine S-methyltransferase 1 BHMT 0.0631
191 Peptide methionine sulfoxide reductase MSRA 0.061
5455 Arylsulfatase A ARSA 0.0518
840 Methionine synthase reductase, mitochondrial MTRR 0.0515
833 Organic cation/carnitine transporter 1 SLC22A4 0.0507
4200 Cytochrome P450 1A2 CYP1A2 0.0493
72 Seryl-tRNA synthetase, cytoplasmic SARS 0.0485
809 Methionine synthase MTR 0.0479
2935 Methionine synthase metH 0.0479
184 L-serine dehydratase SDS 0.0451
491 Serine palmitoyltransferase 1 SPTLC1 0.0451
431 Serine racemase SRR 0.0451
727 Serine palmitoyltransferase 2 SPTLC2 0.0451
6016 Cytochrome P450 2C19 CYP2C19 0.0431
349 Serine--pyruvate aminotransferase AGXT 0.0425
4411 DNA protection during starvation protein dps 0.0421
5423 UPF0010 protein HI1317 HI_1317 0.0421
3780 Lipoprotein nlpI precursor nlpI 0.042
5424 Endonuclease VIII-like 1 NEIL1 0.042
3917 Methylenetetrahydrofolate reductase MTHFR 0.0416
4119 Cytochrome P450 2D6 CYP2D6 0.0412
3583 6-phosphogluconolactonase pgl 0.0398
3186 Soluble calcium-activated nucleotidase 1 CANT1 0.0375
2795 Methionine aminopeptidase 2 METAP2 0.037
3164 Biotin synthase bioB 0.0367
3221 Cytochrome c4 cc4 0.0361
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0338
4924 Cytochrome P450 2C8 CYP2C8 0.0326
3259 Autolysin lytA 0.0321
5718 Cytochrome P450 2A6 CYP2A6 0.031
207 Glutathione synthetase GSS 0.0291
5269 Glutathione synthetase gshB 0.0291
3941 Amine oxidase [flavin-containing] A MAOA 0.029
3939 Amine oxidase [flavin-containing] B MAOB 0.0285
6030 Cytochrome P450 2B6 CYP2B6 0.0282
183 Vascular endothelial growth factor A VEGFA 0.0262
89 Cysteine sulfinic acid decarboxylase CSAD 0.0262
171 Cysteine dioxygenase CDO-1 0.0259
4064 Probable cysteinyl-tRNA synthetase, mitochondrial CARS2 0.0259
1314 Thiamine transporter 2 SLC19A3 0.0259
774 Cysteinyl-tRNA synthetase, cytoplasmic CARS 0.0259
2723 Cholera enterotoxin subunit B ctxB 0.0251
1588 Multidrug resistance protein 1 ABCB1 0.0246
6024 Cytochrome P450 1A1 CYP1A1 0.0245
169 Cysteine desulfurase, mitochondrial NFS1 0.0243
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0237
668 Glutamate--cysteine ligase regulatory subunit GCLM 0.0217
318 Alpha-2A adrenergic receptor ADRA2A 0.0216
193 Beta-1 adrenergic receptor ADRB1 0.0211
586 Aspartate aminotransferase, cytoplasmic GOT1 0.021
146 Androgen receptor AR 0.021
626 Cysteine dioxygenase type 1 CDO1 0.0209
868 Cystathionine gamma-lyase CTH 0.0208
766 Beta-2 adrenergic receptor ADRB2 0.0205
1999 Methylated-DNA--protein-cysteine methyltransferase MGMT 0.02
186 Glutamate--cysteine ligase catalytic subunit GCLC 0.0192
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0181
4118 Cytochrome P450 3A5 CYP3A5 0.016
1998 Protein-L-isoaspartate(D-aspartate) O-methyltransferase PCMT1 0.0159
2551 Cobalt-precorrin-4 C(11)-methyltransferase cbiF 0.0159
4313 Probable tRNA/rRNA methyltransferase HI0766 trmL 0.0159
4316 Mycolic acid synthase pcaA 0.0159
4331 Chemotaxis protein methyltransferase cheR 0.0159
4323 Modification methylase HhaI hhaIM 0.0159
4314 Modification methylase PvuII pvuIIM 0.0159
3724 Protein methyltransferase hemK hemK 0.0159
4329 Uroporphyrinogen-III C-methyltransferase cobA 0.0159
4324 Histone-lysine N-methyltransferase, H3 lysine-4 specific SET7 SETD7 0.0159
4330 Hypothetical protein TTHA0667 TTHA0667 0.0159
4315 DNA adenine methylase DAM 0.0159
4309 S-adenosyl-L-methionine-dependent methyltransferase mraW rsmH 0.0159
4333 Protein-L-isoaspartate O-methyltransferase pcm 0.0159
3811 Cytochrome P450 19A1 CYP19A1 0.0145
575 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial GCAT 0.0139
455 5-aminolevulinate synthase, nonspecific, mitochondrial ALAS1 0.0138
681 Glycine dehydrogenase [decarboxylating], mitochondrial GLDC 0.0138
4332 Modification methylase TaqI taqIM 0.0135
4310 rRNA adenine N-6-methyltransferase ermC' 0.0135
4306 HemK protein TM_0488 0.0135
2297 Genome polyprotein Not Available 0.0132
2322 Genome polyprotein Not Available 0.0132
2694 Genome polyprotein Not Available 0.0132
2719 Genome polyprotein Not Available 0.0132
2860 Genome polyprotein Not Available 0.0132
2928 Genome polyprotein Not Available 0.0132
3160 Genome polyprotein Not Available 0.0132
3260 Genome polyprotein Not Available 0.0132
4783 Genome polyprotein Not Available 0.0132
5726 Genome polyprotein Not Available 0.0132
5779 Genome polyprotein Not Available 0.0132
5867 Genome polyprotein Not Available 0.0132
6253 Genome polyprotein Not Available 0.0132
6301 Genome polyprotein Not Available 0.0132
6380 Genome polyprotein Not Available 0.0132
6381 Genome polyprotein Not Available 0.0132
6437 Genome polyprotein Not Available 0.0132
6520 Genome polyprotein Not Available 0.0132
6521 Genome polyprotein Not Available 0.0132
6652 Genome polyprotein Not Available 0.0132
6734 Genome polyprotein Not Available 0.0132
6735 Genome polyprotein Not Available 0.0132
6736 Genome polyprotein Not Available 0.0132
6737 Genome polyprotein Not Available 0.0132
6738 Genome polyprotein Not Available 0.0132
6739 Genome polyprotein Not Available 0.0132
6744 Genome polyprotein Not Available 0.0132
6748 Genome polyprotein Not Available 0.0132
6894 Genome polyprotein Not Available 0.0132
6898 Genome polyprotein Not Available 0.0132
482 Glycine receptor subunit alpha-1 GLRA1 0.0132
3117 Carminomycin 4-O-methyltransferase dnrK 0.0131
6107 Cytochrome P450 3A7 CYP3A7 0.013
4302 METHOXY MYCOLIC ACID SYNTHASE 2 MMAA2 mmaA2 0.013
2242 Cyclopropane-fatty-acyl-phospholipid synthase 2 cmaA2 0.013
4318 Siroheme synthase cysG 0.0129
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0128
3884 SHMT2 protein SHMT2 0.0125
3901 SHMT2 protein SHMT2 0.0125
3885 Hypothetical protein DKFZp686P09201 DKFZp686P09201 0.0125
3879 Serine hydroxymethyltransferase 2 Not Available 0.0125
321 Serine hydroxymethyltransferase, mitochondrial SHMT2 0.0125
2653 Modification methylase RsrI rsrIM 0.0124
114 Alanine--glyoxylate aminotransferase 2, mitochondrial AGXT2 0.0121
4327 RdmB rdmB 0.0121
442 Envelope glycoprotein gp41 0.012
4859 Envelope glycoprotein env 0.012
4055 Bile acid CoA:amino acid N-acyltransferase BAAT 0.012
4061 Peroxisomal sarcosine oxidase PIPOX 0.0119
4058 Glycine N-acyltransferase-like protein 2 GLYATL2 0.0119
4057 Glycine N-acyltransferase GLYAT 0.0119
4059 Glycine N-acyltransferase-like protein 1 GLYATL1 0.0119
4056 N-arachidonyl glycine receptor GPR18 0.0119
1236 Sodium- and chloride-dependent glycine transporter 1 SLC6A9 0.0119
1466 Glycyl-tRNA synthetase GARS 0.0119
4062 Sodium- and chloride-dependent glycine transporter 2 SLC6A5 0.0119
4060 Vesicular inhibitory amino acid transporter SLC32A1 0.0119
1088 5-aminolevulinate synthase, erythroid-specific, mitochondrial ALAS2 0.0119
4311 tRNA TRDMT1 0.0116
4325 tRNA trmD 0.0116
4328 tRNA trmD 0.0116
367 Serine hydroxymethyltransferase, cytosolic SHMT1 0.0112
20 Prostaglandin G/H synthase 1 PTGS1 0.0109
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0108
4054 Glycine cleavage system H protein, mitochondrial GCSH 0.0103
624 Guanidinoacetate N-methyltransferase GAMT 0.0101
4992 Cytochrome c peroxidase Not Available 0.0101
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.01
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.01
136 Estrogen receptor ESR1 0.0099
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0098
2557 Cap-specific mRNA PAPS 0.0096
62 Glycine receptor subunit beta GLRB 0.0095
383 Glycine amidinotransferase, mitochondrial GATM 0.0092
260 Cytochrome P450 51 ERG11 0.0089
761 Cytochrome P450 51 ERG11 0.0089
3163 Cytochrome P450 51 cyp51 0.0089
820 Glycine receptor subunit alpha-2 GLRA2 0.0088
4366 Riboflavin kinase/FMN adenylyltransferase TM_0857 0.0088
587 Serum albumin ALB 0.0085
3809 Estrogen-related receptor gamma ESRRG 0.0085
4203 Histamine N-methyltransferase HNMT 0.0084
974 Phenylethanolamine N-methyltransferase PNMT 0.0084
593 Proton-coupled amino acid transporter 1 SLC36A1 0.0082
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.008
2697 Uridine-cytidine kinase 2 UCK2 0.008
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0078
290 Prostaglandin G/H synthase 2 PTGS2 0.0078
492 Histamine H1 receptor HRH1 0.0078
831 D(2) dopamine receptor DRD2 0.0078
461 Glycine receptor subunit alpha-3 GLRA3 0.0078
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0077
153 Dopamine beta-hydroxylase DBH 0.0075
23 D(1A) dopamine receptor DRD1 0.0075
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0074
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0074
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0074
5583 RNA 3'-terminal phosphate cyclase rtcA 0.0073
5577 N5-carboxyaminoimidazole ribonucleotide mutase purE 0.0073
2300 Lysozyme E 0.0073
3633 Lysozyme R 0.0073
5597 Lysozyme 17 0.0073
5588 Cell division protein FtsY TM_0570 0.0073
5591 Complement component C8 gamma chain C8G 0.0073
3792 KHG/KDPG aldolase [Includes: 4-hydroxy-2-oxoglutarate aldolase eda 0.0073
5582 Regulator of transcription; stringent starvation protein A sspA 0.0073
4238 50S ribosomal protein L4 rplD 0.0073
5578 50S ribosomal protein L4 rplD 0.0073
6173 50S ribosomal protein L4 rplD 0.0073
6219 50S ribosomal protein L4 rplD 0.0073
4695 UPF0124 protein yfiH yfiH 0.0073
5060 Intron-associated endonuclease 1 ITEVIR 0.0073
5590 N utilization substance protein B homolog nusB 0.0073
5598 Glycerol uptake operon antiterminator-related protein TM_1436 0.0073
5600 Pyruvate decarboxylase pdc 0.0073
2838 Ribose-5-phosphate isomerase A rpiA 0.0073
2952 Ribose-5-phosphate isomerase A rpiA 0.0073
5595 Ribose-5-phosphate isomerase A rpiA 0.0073
5586 Pleckstrin homology domain-containing family A member 1 PLEKHA1 0.0073
5593 Transferase Not Available 0.0073
4375 Glutamine synthetase 1 glnA1 0.0073
5575 Short tail fiber protein 12 0.0073
5592 Ribonucleoside-diphosphate reductase subunit beta nrdF 0.0073
5587 Iron(III)-binding periplasmic protein fbpA 0.0073
5581 Beta-fructosidase bfrA 0.0073
5580 Hexon protein PII 0.0073
5574 Invasin YPTB1668 0.0073
2230 Catalase CAT 0.0073
3249 Catalase katA 0.0073
3625 Catalase katA 0.0073
4539 Catalase katA 0.0073
4941 Catalase katB 0.0073
16 Adenosine A1 receptor ADORA1 0.007
3087 Nicotinate-nucleotide adenylyltransferase nadD 0.007
4469 Nicotinate-nucleotide adenylyltransferase nadD 0.007
869 Estrogen receptor beta ESR2 0.0069
862 Multidrug resistance-associated protein 1 ABCC1 0.0069
6147 Solute carrier family 22 member 3 SLC22A3 0.0067
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0067
6145 Solute carrier family 22 member 1 SLC22A1 0.0067
824 Sodium-dependent serotonin transporter SLC6A4 0.0067
1729 Solute carrier family 22 member 6 SLC22A6 0.0066
1898 Cytochrome P450 1B1 CYP1B1 0.0066
5006 RNASE4 protein RNASE4 0.0064
4533 Glyoxalase family protein BC_1747 0.0064
2555 Pol polyprotein pol 0.0064
3242 Pol polyprotein gag-pol 0.0064
3471 Pol polyprotein gag-pro-pol 0.0064
5256 Pol polyprotein pol 0.0064
6469 Pol polyprotein gag-pol 0.0064
6565 Pol polyprotein Not Available 0.0064
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0064
3085 Molybdopterin-guanine dinucleotide biosynthesis protein A mobA 0.0064
373 Transthyretin TTR 0.0064
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0063
5328 Prostaglandin F synthase Tb11.02.2310 0.0063
3729 Citrate synthase gltA 0.0063
4575 Citrate synthase cit 0.0063
4580 Citrate synthase gltA 0.0063
6144 Solute carrier family 22 member 2 SLC22A2 0.0063
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0063
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.0063
3132 Tryptophan synthase alpha chain trpA 0.0062
6568 Tryptophan synthase alpha chain trpA 0.0062
5599 3-carboxy-cis,cis-muconate cycloisomerase pcaB 0.0062
355 GMP synthase [glutamine-hydrolyzing] GMPS 0.0062
4353 GMP synthase [glutamine-hydrolyzing] guaA 0.0062
1467 Tumor necrosis factor ligand superfamily member 13B TNFSF13B 0.0062
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0061
537 ATP synthase delta chain, mitochondrial ATP5D 0.0059
6106 Cytochrome P450 2C18 CYP2C18 0.0059
638 D(3) dopamine receptor DRD3 0.0059
2521 Cell division protein ftsZ ftsZ 0.0059
3301 Cell division protein ftsZ ftsZ 0.0059
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0059
556 Alpha-1A adrenergic receptor ADRA1A 0.0059
4373 Medium-chain-fatty-acid--CoA ligase Not Available 0.0059
2603 Beta-lactamase II blm 0.0058
2149 Angiogenin ANG 0.0058
2164 Multidrug resistance-associated protein 4 ABCC4 0.0058
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0057
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0057
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0057
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0057
857 Malate dehydrogenase, mitochondrial MDH2 0.0057
5682 Ribonuclease pancreatic RNASE1 0.0057
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0056
613 Atrial natriuretic peptide receptor A NPR1 0.0056
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0056
3913 Glutamic acid decarboxylase GAD65 0.0056
705 Glutamate receptor 1 GRIA1 0.0056
3486 Fumarate hydratase class II fumC 0.0055
2286 Isocitrate dehydrogenase [NADP] icd 0.0055
2302 Isocitrate dehydrogenase [NADP] icd 0.0055
2771 Isocitrate dehydrogenase [NADP] icd 0.0055
2942 Sialidase nanH 0.0054
3546 Sialidase nedA 0.0054
2869 1-deoxy-D-xylulose 5-phosphate reductoisomerase dxr 0.0054
1123 Eosinophil cationic protein RNASE3 0.0054
332 Beta-lactamase blaZ 0.0054
2478 Beta-lactamase ampC 0.0054
2613 Beta-lactamase ampC 0.0054
2635 Beta-lactamase ampC 0.0054
2700 Beta-lactamase penP 0.0054
5445 Beta-lactamase blaB 0.0054
6019 Beta-lactamase SHV-7 0.0054
6701 Beta-lactamase cphA 0.0054
502 5-hydroxytryptamine 2A receptor HTR2A 0.0053
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0053
2805 Heparan sulfate glucosamine 3-O-sulfotransferase 3A1 HS3ST3A1 0.0053
468 Cytochrome P450 4A11 CYP4A11 0.0052
2452 Tryptophanyl-tRNA synthetase trpS 0.0052
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0052
465 Calmodulin CALM1 0.0052
713 Sodium-dependent dopamine transporter SLC6A3 0.0051
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0051
432 D(4) dopamine receptor DRD4 0.005
118 Organic cation/carnitine transporter 2 SLC22A5 0.005
735 Alanine aminotransferase 1 GPT 0.005
3904 Alanine aminotransferase 2 GPT2 0.005
2936 Oxygen-insensitive NAD(P)H nitroreductase nfnB 0.005
5184 Oxygen-insensitive NAD(P)H nitroreductase nfnB 0.005
3915 Cysteine sulfinic acid decarboxylase-related protein 1 CSAD 0.005
306 Pyridoxal phosphate phosphatase PDXP 0.005
3881 Selenocysteine lyase variant Not Available 0.005
3887 Phosphorylase PYGB 0.005
3908 P-selectin cytoplasmic tail-associated protein pcap 0.005
3914 Alanine-glyoxylate aminotransferase homolog TLH6 0.005
3883 Ornithine aminotransferase variant Not Available 0.005
3893 DDC protein DDC 0.005
3911 Uncharacterized protein C20orf38 SPTLC3 0.005
3910 O-phosphoseryl-tRNA(Sec) selenium transferase SEPSECS 0.005
3906 Serine dehydratase-like SDSL 0.005
3896 CDNA FLJ46802 fis, clone TRACH3032150, moderately similar to Cysteine sulfinic acid decarboxylase GADL1 0.005
3891 Putative L-Dopa decarboxylase DDC 0.005
3909 Hepatic peroxysomal alanine:glyoxylate aminotransferase Not Available 0.005
855 Sphingosine-1-phosphate lyase 1 SGPL1 0.005
3878 GAD1 protein GAD1 0.005
3880 Serine hydroxymethyltransferase 1 Not Available 0.005
3903 Aminolevulinate, delta-, synthase 2 ALAS2 0.005
664 Glutamate decarboxylase 2 GAD2 0.005
3890 Glutamate decarboxylase 2 GAD2 0.005
3886 Migration-inducing protein 4 ALAS1 0.005
3894 KIAA0251 protein PDXDC1 0.005
3875 Glycogen phosphorylase, brain form PYGB 0.005
3882 Brain glycogen phosphorylase variant Not Available 0.005
3905 Molybdenum cofactor sulfurase MOCOS 0.005
1178 Adenosine A2a receptor ADORA2A 0.0048
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0048
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0047
3478 Glucose-1-phosphate thymidylyltransferase rmlA 0.0047
4277 Glucose-1-phosphate thymidylyltransferase rmlA 0.0047
5579 Carboxypeptidase B CPB1 0.0047
776 Bile salt export pump ABCB11 0.0047
128 Adenine phosphoribosyltransferase APRT 0.0047
518 Peroxidase/catalase T katG 0.0047
3384 Macrophage migration inhibitory factor MIF 0.0046
6141 Sodium/bile acid cotransporter SLC10A1 0.0045
6031 Cytochrome P450 3A43 CYP3A43 0.0045
3899 Alanine--glyoxylate aminotransferase 2-like 2 AGXT2L2 0.0045
790 DNA polymerase subunit alpha B POLA2 0.0045
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0045
534 Threonine synthase-like 1 THNSL1 0.0044
5293 Shikimate kinase 2 aroL 0.0044
5266 Activator of hgdC 0.0044
5287 Signaling protein Not Available 0.0044
5288 Shikimate kinase aroK 0.0044
5304 UPF0166 protein TM_0021 TM_0021 0.0044
5292 Putative partitioning protein TT_C1605 0.0044
5314 UPF0079 ATP-binding protein HI0065 HI_0065 0.0044
3199 Phosphopantetheine adenylyltransferase coaD 0.0044
3543 Phosphopantetheine adenylyltransferase coaD 0.0044
3567 Phosphopantetheine adenylyltransferase coaD 0.0044
5289 Phosphopantetheine adenylyltransferase coaD 0.0044
5283 D-alanine--D-alanine ligase B ddlB 0.0044
5281 Plasmid segregation protein parM parM 0.0044
5276 Chromosomal replication initiator protein dnaA dnaA 0.0044
1549 Heat shock 70 kDa protein 1 HSPA1A 0.0044
5259 Transcriptional regulator ntrC1 0.0044
6699 Transcriptional regulator Cgl2612 0.0044
5290 ATP-dependent hsl protease ATP-binding subunit hslU hslU 0.0044
5638 ATP-dependent hsl protease ATP-binding subunit hslU hslU 0.0044
5270 ATP-dependent Clp protease ATP-binding subunit clpX clpX 0.0044
5291 Glycogen synthase 1 glgA1 0.0044
3777 ATP-dependent Clp protease ATP-binding subunit clpA clpA 0.0044
2874 Nitrogenase iron protein 1 nifH1 0.0044
4346 Polynucleotide kinase pseT 0.0044
4794 Phosphoenolpyruvate carboxykinase [ATP] pckA 0.0044
5275 Multidrug resistance ABC transporter ATP-binding and permease protein lmrA 0.0044
5308 Preprotein translocase secA 1 subunit secA1 0.0044
5285 Kinesin heavy chain KIF5B 0.0044
5305 Phosphoribosylaminoimidazole carboxylase ATPase subunit purK 0.0044
5299 D-alanine--D-alanine ligase ddl 0.0044
6598 D-alanine--D-alanine ligase ddl 0.0044
5284 Large T antigen Not Available 0.0044
5315 Chaperone protein htpG htpG 0.0044
3982 Phosphoribosylformylglycinamidine synthase PFAS 0.0044
5261 Phosphoribosylformylglycinamidine synthase purL 0.0044
5277 Preprotein translocase subunit secA secA 0.0044
5264 DNA replication protein REP 0.0044
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0044
3874 Proline synthetase co-transcribed bacterial homolog protein PROSC 0.0044
665 Phosphoserine aminotransferase PSAT1 0.0043
4652 Phosphoserine aminotransferase serC 0.0043
801 Kynurenine/alpha-aminoadipate aminotransferase mitochondrial AADAT 0.0043
3895 Kynurenine--oxoglutarate transaminase 3 CCBL2 0.0043
420 Glutamate decarboxylase 1 GAD1 0.0043
3900 Glutamate decarboxylase 1 GAD1 0.0043
3 Histidine decarboxylase HDC 0.0043
444 Alcohol dehydrogenase 1B ADH1B 0.0043
499 Arginine decarboxylase ADC 0.0043
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0042
6102 Arylamine N-acetyltransferase 2 NAT2 0.0042
163 D(1B) dopamine receptor DRD5 0.0042
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0042
4943 Cytochrome c6 petJ 0.0041
4934 Cytochrome c-551 nirM 0.0041
5218 Cytochrome c-551 nirM 0.0041
4936 Cytochrome c2 iso-2 Not Available 0.0041
4981 Iron-starvation protein PigA pigA 0.0041
4994 Hemoglobin-like protein HbO glbO 0.0041
4915 Cytochrome c-550 psbV 0.0041
4959 Cytochrome c-550 psbV 0.0041
5216 Cytochrome c-550 psbV 0.0041
4925 Cytochrome c-type protein SHP shp 0.0041
4998 Hemoglobin-like protein yjbI yjbI 0.0041
4905 Cytochrome c2 Not Available 0.0041
4939 Cytochrome c2 cycA 0.0041
4964 Cytochrome c2 cycA 0.0041
4979 Cytochrome c2 cycA 0.0041
6673 Cytochrome c2 cycA 0.0041
4909 CooA protein cooA 0.0041
4947 Bacterial hemoglobin vhb 0.0041
4975 Cytochrome c-556 RPA3973 0.0041
4984 Neuroglobin NGB 0.0041
4954 Soluble cytochrome b558 Not Available 0.0041
251 Alcohol dehydrogenase 1A ADH1A 0.0041
4961 Hemophore HasA hasA 0.0041
4910 Cytoglobin CYGB 0.0041
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0041
4976 Apocytochrome f petA 0.0041
6407 Apocytochrome f petA 0.0041
4916 Cyanoglobin glbN 0.0041
5000 HemO hemO 0.0041
4935 Cytochrome c-554 cycA1 0.0041
644 Heme oxygenase 2 HMOX2 0.0041
4982 Heme oxygenase 2 pbsA2 0.0041
4942 Diheme cytochrome c napB napB 0.0041
4931 Cytochrome P450 167A1 CYP167A1 0.0041
4922 Cytochrome c, putative SO_4144 0.0041
4971 Nonaheme cytochrome c hmcA 0.0041
4989 Cytochrome c551 peroxidase ccp 0.0041
5222 Cytochrome c551 peroxidase ccpA 0.0041
4904 Cytochrome c family protein GSU1996 0.0041
4907 Cytochrome c-L moxG 0.0041
6865 Cytochrome c-L moxG 0.0041
4999 Cytochrome P450 165B3 CYP165B3 0.0041
4972 P450cin cinA 0.0041
4764 Cytochrome P450 165C4 CYP165C4 0.0041
4960 Putative cytochrome P450-family protein SCO7417 0.0041
4926 Heme-based aerotactic transducer hemAT hemAT 0.0041
4952 Catalase/peroxidase katA 0.0041
3093 Catalase HPII katE 0.0041
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0041
4937 Cytochrome oxidase subunit II rcoxA 0.0041
4993 Hydroxylamine oxidoreductase hao1 0.0041
4903 Methyl-accepting chemotaxis protein Tar4 0.0041
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0041
777 Tumor necrosis factor TNF 0.0041
435 Kynureninase KYNU 0.004
4654 Kynureninase kynU 0.004
274 Muscarinic acetylcholine receptor M5 CHRM5 0.004
3877 Growth-inhibiting protein 18 GIG18 0.004
341 5-hydroxytryptamine 3 receptor HTR3A 0.004
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.004
6149 Solute carrier family 22 member 10 SLC22A10 0.004
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0039
3823 Cytokine receptor common gamma chain IL2RG 0.0039
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0039
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0038
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0038
1024 Solute carrier family 22 member 11 SLC22A11 0.0038
426 Aspartate aminotransferase, mitochondrial GOT2 0.0038
763 Tyrosine aminotransferase TAT 0.0038
5493 Tyrosine aminotransferase Not Available 0.0038
472 Ornithine aminotransferase, mitochondrial OAT 0.0037
6167 Organic solute transporter subunit beta OSTB 0.0037
6166 Organic solute transporter subunit alpha OSTA 0.0037
3175 Glutamate--cysteine ligase gshA 0.0037
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.0037
2298 Cytochrome P450-cam camC 0.0037
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0037
3426 Glutamine synthetase glnA 0.0036
3987 Glutamine synthetase GLUL 0.0036
914 Formimidoyltransferase-cyclodeaminase FTCD 0.0036
203 Pyridoxine-5'-phosphate oxidase PNPO 0.0036
4106 Guanylate kinase GUK1 0.0036
4516 Guanylate kinase gmk 0.0036
413 Amidophosphoribosyltransferase PPAT 0.0036
2515 Amidophosphoribosyltransferase purF 0.0036
3714 Amidophosphoribosyltransferase purF 0.0036
4837 Cag-alfa cag-alfa 0.0036
6277 Heat shock cognate 71 kDa protein HSPA8 0.0036
4774 NTPase P4 Not Available 0.0036
3390 Aminoglycoside 3'-phosphotransferase aphA 0.0036
6029 Aminoglycoside 3'-phosphotransferase aphA1 0.0036
5302 TrwB trwB 0.0036
5265 FtsH ftsH 0.0036
4839 DNA polymerase III subunit tau dnaX 0.0036
5646 Galactokinase GALK1 0.0036
4838 PMS1 protein homolog 2 PMS2 0.0036
1010 Cytochrome P450 51A1 CYP51A1 0.0036
5189 Trimethylamine dehydrogenase tmd 0.0036
2270 Dephospho-CoA kinase coaE 0.0036
822 Aldose reductase AKR1B1 0.0036
2284 Adenylate kinase adk 0.0036
2296 Adenylate kinase adk 0.0036
2311 Adenylate kinase adk 0.0036
2312 Adenylate kinase Not Available 0.0036
3470 Hypothetical protein MG245 homolog MPN_348 0.0036
2751 Holliday junction ATP-dependent DNA helicase ruvB ruvB 0.0036
4755 Holliday junction ATP-dependent DNA helicase ruvB ruvB 0.0036
5295 2-keto-3-deoxy-gluconate kinase TT_P0036 0.0036
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0035
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0035
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0034
301 Kynurenine--oxoglutarate transaminase 1 CCBL1 0.0034
724 Interleukin-2 receptor alpha chain IL2RA 0.0034
717 Interleukin-2 receptor subunit beta IL2RB 0.0034
590 5-hydroxytryptamine 2C receptor HTR2C 0.0034
2178 Metabotropic glutamate receptor 5 GRM5 0.0034
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0034
2683 Mono-ADP-ribosyltransferase C3 C3 0.0034
811 Translocator protein TSPO 0.0034
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0033
795 Branched-chain-amino-acid aminotransferase, mitochondrial BCAT2 0.0033
320 5-hydroxytryptamine 1A receptor HTR1A 0.0033
4116 Dihydropteroate synthetase Not Available 0.0033
574 Branched-chain-amino-acid aminotransferase, cytosolic BCAT1 0.0033
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0033
340 Apoptotic protease-activating factor 1 APAF1 0.0033
4122 Histone deacetylase 2 HDAC2 0.0033
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0033
2390 Nonsecretory ribonuclease RNASE2 0.0033
5312 Kinesin-like protein KIF1A KIF1A 0.0033
5300 Antigen peptide transporter 1 TAP1 0.0032
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0032
2922 Glycerol kinase glpK 0.0032
6142 Solute carrier family 22 member 8 SLC22A8 0.0032
5271 Focal adhesion kinase 1 PTK2 0.0032
4037 Hypothetical protein GPX1 0.0032
4297 Hypothetical protein SP_1951 0.0032
4521 Hypothetical protein BC_2969 0.0032
4540 Hypothetical protein TM_1070 0.0032
4555 Hypothetical protein MT1739 0.0032
4569 Hypothetical protein mshD 0.0032
4578 Hypothetical protein PA3270 0.0032
4747 Hypothetical protein PA3967 0.0032
5177 Hypothetical protein TM_0096 0.0032
5194 Hypothetical protein PA1204 0.0032
5240 Hypothetical protein Rv2991 0.0032
5370 Hypothetical protein TM_1158 0.0032
5710 Hypothetical protein Tb927.5.1360 0.0032
6766 O-GlcNAcase BT_4395 BT_4395 0.0031
517 Alcohol dehydrogenase 1C ADH1C 0.0031
3090 Chitosanase csn 0.0031
4149 Nuclear factor NF-kappa-B p100 subunit NFKB2 0.0031
94 5-hydroxytryptamine 4 receptor HTR4 0.0031
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0031
4289 Cytochrome P450 TT_P0059 0.0031
6262 Cytochrome P450 staP 0.0031
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0031
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0031
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0031
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0031
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0031
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0031
2282 Protein recA recA 0.0031
2315 Protein recA recA 0.0031
2332 Protein recA recA 0.0031
5263 Protein recA recA 0.0031
408 Riboflavin kinase RFK 0.0031
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0031
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0031
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0031
4920 Peroxidase/catalase katG 0.0031
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0031
3570 Cytochrome P450 152A1 cypC 0.003
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.003
2615 Chemotaxis protein cheA cheA 0.003
1181 Alpha-1-acid glycoprotein 1 ORM1 0.003
2371 Pantothenate kinase coaA 0.003
4990 PpcA ppcA 0.003
2892 Acetylglutamate kinase argB 0.003
3550 Acetylglutamate kinase argB 0.003
4923 Cytochrome c3 DvMF_2499 0.003
4945 Cytochrome c3 Not Available 0.003
4949 Cytochrome c3 DVU_3171 0.003
4968 Cytochrome c3 cytc3 0.003
4997 Cytochrome c3 SO_2727 0.003
5219 Cytochrome c3 cyd 0.003
4948 Cytochrome c-553 Not Available 0.003
4902 Nine-heme cytochrome c Ddes_2038 0.003
3189 High-molecular-weight cytochrome c hmcA 0.003
4813 Heme oxygenase hmuO 0.003
5769 Heme oxygenase Not Available 0.003
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.003
4988 Sulfite oxidase, mitochondrial SUOX 0.003
1881 Hexokinase-1 HK1 0.003
2950 Inositol-trisphosphate 3-kinase A ITPKA 0.003
3669 Ribokinase rbsK 0.003
2119 Cytochrome b5 CYB5A 0.003
2915 Sensor protein fixL fixL 0.003
4944 Sensor protein fixL fixL 0.003
3375 Acidic cytochrome c3 Not Available 0.003
4385 Cytochrome c' Not Available 0.003
4967 Cytochrome c' cycA 0.003
5038 Cytochrome c' Not Available 0.003
5223 Cytochrome c' cycP 0.003
825 Arsenical pump-driving ATPase ASNA1 0.003
3435 Arsenical pump-driving ATPase arsA 0.003
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.003
6857 [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 2, mitochondrial PDK2 0.003
788 Creatine kinase M-type CKM 0.003
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.003
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0029
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0029
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0029
2727 S-adenosylmethionine synthetase metK 0.0029
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0029
3947 Xanthine dehydrogenase/oxidase XDH 0.0029
6832 Serine/threonine-protein kinase SRPK2 SRPK2 0.0029
632 Alpha-1B adrenergic receptor ADRA1B 0.0029
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0028
6390 Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 ATP2A1 0.0028
1253 Interferon gamma IFNG 0.0028
390 Adenosine A3 receptor ADORA3 0.0028
10 Glycogen phosphorylase, liver form PYGL 0.0028
1757 Myeloperoxidase MPO 0.0028
2817 Phosphoribosylglycinamide formyltransferase 2 purT 0.0028
2334 Dethiobiotin synthetase bioD 0.0027
6555 Dethiobiotin synthetase bioD 0.0027
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0027
3404 Exotoxin A eta 0.0027
2617 Nitric oxide synthase oxygenase nos 0.0027
2701 Nitric oxide synthase oxygenase nos 0.0027
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0027
61 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0026
2644 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0026
2710 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0026
3670 Soluble cytochrome b562 precursor cybC 0.0026
3291 Cytochrome c-552 cycA 0.0026
4927 Cytochrome c-552 nrfA 0.0026
4938 Cytochrome c-552 cycA 0.0026
4953 Cytochrome c-552 nrfA 0.0026
5217 Cytochrome c-552 cycM 0.0026
3102 Flavohemoprotein hmp 0.0026
4969 Flavohemoprotein hmp 0.0026
201 Glutamate dehydrogenase 1, mitochondrial GLUD1 0.0026
4604 Liver carboxylesterase 1 CES1 0.0026
4386 Hemoglobin-like protein HbN glbN 0.0026
3411 Cytochrome P450 121 cyp121 0.0026
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0026
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0026
48 Pyridoxal kinase PDXK 0.0026
6220 Aryl hydrocarbon receptor AHR 0.0025
891 Dihydropteroate synthase folP 0.0025
5359 Dihydropteroate synthase folP 0.0025
7175 Dihydropteroate synthase sulI 0.0025
2511 MAP kinase-activated protein kinase 2 MAPKAPK2 0.0025
885 5-hydroxytryptamine 1B receptor HTR1B 0.0025
2317 UDP-N-acetylmuramoylalanine--D-glutamate ligase murD 0.0025
702 UMP-CMP kinase CMPK1 0.0025
2091 Endoplasmin HSP90B1 0.0025
2251 Thymidylate kinase tmk 0.0025
2254 Thymidylate kinase DTYMK 0.0025
3522 Thymidylate kinase tmk 0.0025
6395 Myosin-14 MYH14 0.0025
789 Alpha-1D adrenergic receptor ADRA1D 0.0024
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0024
817 DNA topoisomerase 2-alpha TOP2A 0.0024
6126 Carbonic anhydrase 7 CA7 0.0024
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0024
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0024
605 Fumarate reductase flavoprotein subunit frdA 0.0024
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0024
3673 Fumarate reductase flavoprotein subunit fccA 0.0024
4912 Fumarate reductase flavoprotein subunit ifcA 0.0024
6549 Fumarate reductase flavoprotein subunit frdA 0.0024
1422 Serine/threonine-protein kinase 6 AURKA 0.0024
3127 Nitrite reductase nirS 0.0024
3284 Nitrite reductase nirS 0.0024
473 L-lactate dehydrogenase A chain LDHA 0.0024
2972 6-deoxyerythronolide B hydroxylase eryF 0.0024
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0024
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0023
7 Nitric oxide synthase, inducible NOS2 0.0023
3379 Kinesin-like protein KIF11 KIF11 0.0023
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0023
3456 Heat shock protein HSP 90-beta HSP90AB1 0.0023
6014 Cytochrome P450 2A13 CYP2A13 0.0023
4608 Putative cytochrome P450 SCO1207 0.0022
4963 Putative cytochrome P450 SCO2884 0.0022
6254 Putative cytochrome P450 SCO6998 0.0022
3822 Actin, alpha skeletal muscle ACTA1 0.0022
275 Arachidonate 5-lipoxygenase ALOX5 0.0022
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0022
504 Mast/stem cell growth factor receptor KIT 0.0022
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0022
686 Aldo-keto reductase family 1 member C2 AKR1C2 0.0022
509 Thymidine kinase TK 0.0022
570 Thymidine kinase TK 0.0022
2559 Thymidine kinase TK 0.0022
3430 Thymidine kinase tdk 0.0022
3518 Thymidine kinase TK 0.0022
5301 Thymidine kinase tdk 0.0022
5771 Thymidine kinase ORF36 0.0022
7009 Thymidine kinase ORF36 0.0022
2290 ADP-ribosyl cyclase 2 BST1 0.0022
65 Matrix metalloproteinase-9 Not Available 0.0021
5294 Nucleoside diphosphate kinase A NME1 0.0021
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0021
1152 Glycogen phosphorylase, muscle form PYGM 0.0021
3937 Fatty-acid amide hydrolase FAAH 0.0021
1507 Cytochrome c CYCS 0.0021
1721 Glycogen synthase kinase-3 beta GSK3B 0.0021
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.002
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.002
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.002
4773 Deoxycytidine kinase DCK 0.002
80 Peroxisome proliferator-activated receptor alpha PPARA 0.002
693 Hemoglobin subunit beta HBB 0.002
592 Carbonic anhydrase 4 CA4 0.002
921 Glutamate receptor 2 GRIA2 0.0019
904 Glutathione S-transferase P GSTP1 0.0019
3932 Glutathione S-transferase A2 GSTA2 0.0019
718 Folate receptor gamma FOLR3 0.0019
299 Folate receptor beta FOLR2 0.0019
804 Mitochondrial folate transporter/carrier SLC25A32 0.0019
723 Cytosolic phospholipase A2 PLA2G4A 0.0019
563 Thyroid peroxidase TPO 0.0019
6268 Hydroxyacid oxidase 1 HAO1 0.0019
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0019
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0019
6138 Multidrug resistance protein 3 ABCB4 0.0019
810 Heme oxygenase 1 HMOX1 0.0019
3391 Heme oxygenase 1 pbsA1 0.0019
295 Carbonic anhydrase 1 CA1 0.0019
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0019
291 Nitric-oxide synthase, endothelial NOS3 0.0018
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0018
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0017
908 Glutathione S-transferase theta-1 GSTT1 0.0017
1192 Sulfotransferase 1A1 SULT1A1 0.0017
823 Fibroblast growth factor receptor 2 FGFR2 0.0017
293 Gamma-glutamyl hydrolase GGH 0.0017
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0017
6148 Multidrug resistance-associated protein 7 ABCC10 0.0016
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0016
3601 Dihydropteroate synthase 1 folP1 0.0016
3807 Dihydropteroate synthase 1 folP1 0.0016
3808 Dihydropteroate synthase 2 folP2 0.0016
3923 Cholinesterase BCHE 0.0016
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0016
76 Nitric-oxide synthase, brain NOS1 0.0015
378 Alpha-2C adrenergic receptor ADRA2C 0.0015
365 Dihydrofolate reductase DHFR 0.0015
2381 Dihydrofolate reductase DFR1 0.0015
2833 Dihydrofolate reductase Not Available 0.0015
2931 Dihydrofolate reductase folA 0.0015
3544 Dihydrofolate reductase folA 0.0015
3682 Dihydrofolate reductase folA 0.0015
6642 Dihydrofolate reductase folA 0.0015
6756 Dihydrofolate reductase dfrA 0.0015
725 5-hydroxytryptamine 1D receptor HTR1D 0.0015
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0015
122 P2Y purinoceptor 12 P2RY12 0.0015
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0015
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0015
1650 Heme carrier protein 1 SLC46A1 0.0015
357 Carbonic anhydrase 2 CA2 0.0015
6143 Solute carrier family 22 member 7 SLC22A7 0.0015
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0014
29 Tubulin beta-1 chain TUBB1 0.0014
6136 Multidrug resistance-associated protein 5 ABCC5 0.0014
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0014
161 Tubulin beta chain TUBB 0.0014
312 Tubulin beta chain TUB2 0.0014
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0014
1483 Membrane copper amine oxidase AOC3 0.0014
319 Opioid receptor, sigma 1 OPRS1 0.0014
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0014
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0014
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0014
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0014
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0014
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0013
976 Platelet glycoprotein IX GP9 0.0013
400 Coagulation factor IX F9 0.0013
5461 Coagulation factor IX F9 0.0013
436 5-hydroxytryptamine 2B receptor HTR2B 0.0013
1256 5-hydroxytryptamine 6 receptor HTR6 0.0013
1374 Natriuretic peptides B NPPB 0.0013
1827 Gap junction alpha-1 protein GJA1 0.0013
1908 Vascular cell adhesion protein 1 VCAM1 0.0013
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0012
814 Ryanodine receptor 1 RYR1 0.0012
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0012
6432 Transporter snf 0.0012
4081 Vitamin K epoxide reductase complex subunit 1-like protein 1 VKORC1L1 0.0012
604 Vitamin K-dependent protein Z PROZ 0.0012
716 5-hydroxytryptamine 7 receptor HTR7 0.0012
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0012
174 Sigma 1-type opioid receptor SIGMAR1 0.0012
268 Adenosine A2b receptor ADORA2B 0.0011
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0011
422 Vitamin K-dependent protein C PROC 0.0011
1245 Vitamin K-dependent protein S PROS1 0.0011
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.001
3238 Multidrug resistance protein mexA mexA 0.001
3709 Glycerol uptake facilitator protein glpF 0.001
3116 Bacterioferritin bfr 0.001
4906 Bacterioferritin bfr 0.001
4965 Bacterioferritin bfr 0.001
5489 Ribonucleoside-diphosphate reductase 1 subunit beta nrdB 0.001
3173 Enolase eno 0.001
3336 C4-dicarboxylate transport transcriptional regulatory protein dctD dctD 0.001
3393 TGF-beta receptor type-2 TGFBR2 0.001
6131 Carbonic anhydrase 14 CA14 0.001
448 Vitamin K-dependent gamma-carboxylase GGCX 0.001
6163 Copper-transporting ATPase 2 ATP7B 0.001
6165 Copper-transporting ATPase 1 ATP7A 0.001
997 Protein kinase C beta type PRKCB 0.0009
6122 Carbonic anhydrase 3 CA3 0.0009
847 Mu-type opioid receptor OPRM1 0.0009
6146 High affinity copper uptake protein 1 SLC31A1 0.0009
1275 Estrogen sulfotransferase SULT1E1 0.0009
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0009
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0009
1268 Neuropeptide S receptor NPSR1 0.0009
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0009
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0009
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0009
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0009
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0009
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0009
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0009
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0009
2852 DNA mismatch repair protein mutL mutL 0.0009
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0009
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0009
634 Squalene monooxygenase SQLE 0.0009
7196 Squalene monooxygenase ERG1 0.0009
798 Osteocalcin BGLAP 0.0009
4192 DNA topoisomerase 2-beta TOP2B 0.0009
3191 Histidinol dehydrogenase hisD 0.0009
1050 Bile salt sulfotransferase SULT2A1 0.0009
1970 Protein kinase C alpha type PRKCA 0.0009
2408 Tyrosine-protein kinase SYK SYK 0.0009
3007 Carbonic anhydrase 12 CA12 0.0009
4205 Carbonic anhydrase 9 CA9 0.0009
740 Argininosuccinate synthase ASS1 0.0009
865 Argininosuccinate synthase ASS1 0.0009
2680 Argininosuccinate synthase argG 0.0009
3194 Argininosuccinate synthase argG 0.0009
751 Potassium channel subfamily K member 6 KCNK6 0.0008
731 HIV-1 protease HIV-1 protease 0.0008
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0008
629 Alpha-2B adrenergic receptor ADRA2B 0.0008
6459 Glycodelin PAEP 0.0008
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0008
6073 Potassium channel subfamily K member 9 KCNK9 0.0008
6072 Potassium channel subfamily K member 3 KCNK3 0.0008
1360 Sphingomyelin phosphodiesterase SMPD1 0.0008
4692 A/G-specific adenine glycosylase mutY 0.0008
369 Coagulation factor VII F7 0.0008
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0008
896 Glutathione S-transferase Mu 1 GSTM1 0.0008
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0008
172 Potassium channel subfamily K member 1 KCNK1 0.0008
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0008
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0008
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0008
6137 Multidrug resistance-associated protein 6 ABCC6 0.0008
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0007
84 Nuclear receptor 0B1 NR0B1 0.0007
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0007
3957 Adenosine deaminase ADA 0.0007
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0007
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0007
2802 Endoglucanase G celCCG 0.0007
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0007
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0007
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0007
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0007
6316 ADP-ribosylation factor 1 ARF1 0.0007
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0007
6020 Aldehyde oxidase AOX1 0.0007
469 Annexin A1 ANXA1 0.0007
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0007
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0007
284 DNA-directed RNA polymerase beta chain rpoB 0.0007
5773 DNA-directed RNA polymerase beta chain rpoB 0.0007
2101 Glutathione-requiring prostaglandin D synthase HPGDS 0.0007
2236 Casein kinase II subunit alpha CSNK2A1 0.0007
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0007
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0006
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0006
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0006
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0006
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0006
2207 Rhodopsin RHO 0.0006
239 Coagulation factor X F10 0.0006
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0006
380 Cytochrome P450 17A1 CYP17A1 0.0006
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.0006
1618 High affinity nerve growth factor receptor NTRK1 0.0006
124 Histamine H2 receptor HRH2 0.0006
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0005
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0005
2981 Phospholipase A2, membrane associated PLA2G2A 0.0005
164 Histamine H4 receptor HRH4 0.0005
54 Prothrombin F2 0.0005
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0005
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0005
528 5-hydroxytryptamine 1E receptor HTR1E 0.0004
871 Glucocorticoid receptor NR3C1 0.0004
467 Delta-type opioid receptor OPRD1 0.0004
696 Kappa-type opioid receptor OPRK1 0.0004
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