| Name |
Endonuclease VIII-like 1 |
| Synonyms |
7413 |
| Gene name |
NEIL1 |
| General function |
Involved in damaged DNA binding |
| Specific function |
Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, formamidopyrimidine (Fapy) and 5-hydroxyuracil. Has marginal activity towards 8- oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. Has DNA glycosylase/lyase activity towards mismatched uracil and thymine, in particular in U:C and T:C mismatches |
| Gene sequence |
+ ...
ATGCCTGAGGGCCCCGAGCTGCACCTGGCCAGCCAGTTTGTGAATGAGGCCTGCAGGGCGCTGGTGTTCGGCGGCTGCGTGGAGAAGTCCTCTGTCAGCCGCAACCCTGAGGTGCCCTTTGAGAGCAGTGCCTACCGCATCTCAGCTTCAGCCCGCGGCAAGGAGCTGCGCCTGATACTGAGCCCTCTGCCTGGGGCCCAGCCCCAACAGGAGCCACTGGCCCTGGTCTTCCGCTTCGGCATGTCCGGCTCTTTTCAGCTGGTGCCCCGCGAGGAGCTGCCACGCCATGCCCACCTGCGCTTTTACACGGCCCCGCCTGGCCCCCGGCTCGCCCTATGTTTCGTGGACATCCGCCGGTTCGGCCGCTGGGACCTTGGGGGAAAGTGGCAGCCGGGCCGCGGGCCCTGTGTCTTGCAGGAGTACCAGCAGTTCAGGGAGAATGTGCTACGAAACCTAGCGGATAAGGCCTTTGACCGGCCCATCTGCGAGGCCCTCCTGGACCAGAGGTTCTTCAATGGCATTGGCAACTATCTGCGGGCAGAGATCCTGTACCGGCTGAAGATCCCCCCCTTTGAGAAGGCCCGCTCGGTCCTGGAGGCCCTGCAGCAGCACAGGCCGAGCCCGGAGCTGACCCTGAGCCAGAAGATAAGGACCAAGCTGCAGAATCCAGACCTGCTGGAGCTATGTCACTCAGTGCCCAAGGAAGTGGTCCAGTTGGGGGGCAGGGGCTACGGGTCAGAGAGCGGGGAGGAGGACTTTGCTGCCTTTCGAGCCTGGCTGCGCTGCTATGGCATGCCAGGCATGAGCTCCCTGCAGGACCGGCATGGCCGTACCATCTGGTTCCAGGGGGATCCTGGACCGTTGGCACCCAAAGGGCGCAAGTCCCGCAAAAAGAAATCCAAGGCCACACAGCTGAGTCCTGAGGACAGAGTGGAGGACGCTTTGCCTCCAAGCAAGGCCCCTTCCAGGACACGAAGGGCAAAGAGAGACCTTCCTAAGAGGACTGCAACCCAGCGGCCTGAGGGGACCAGCCTCCAGCAGGACCCAGAAGCTCCCACAGTGCCCAAGAAGGGGAGGAGGAAGGGGCGACAGGCAGCCTCTGGCCACTGCAGACCCCGGAAGGTCAAGGCTGACATCCCATCCTTGGAACCAGAGGGGACCTCAGCCTCTTAG
|
| Protein sequence |
+ ...
MPEGPELHLASQFVNEACRALVFGGCVEKSSVSRNPEVPFESSAYRISASARGKELRLILSPLPGAQPQQEPLALVFRFGMSGSFQLVPREELPRHAHLRFYTAPPGPRLALCFVDIRRFGRWDLGGKWQPGRGPCVLQEYQQFRENVLRNLADKAFDRPICEALLDQRFFNGIGNYLRAEILYRLKIPPFEKARSVLEALQQHRPSPELTLSQKIRTKLQNPDLLELCHSVPKEVVQLGGKGYGSESGEEDFAAFRAWLRCYGMPGMSSLQDRHGRTIWFQGDPGPLAPKGRKSRKKKSKATQLSPEDRVEDALPPSKAPSRTRRAKRDLPKRTATQRPEGTSLQQDPEAPTVPKKGRRKGRQAASGHCRPRKVKADIPSLEPEGTSAS
|
| GO Classification |
| function |
| binding |
| ion binding |
| cation binding |
| transition metal ion binding |
| zinc ion binding |
| process |
| DNA metabolism |
| DNA repair |
| physiological process |
| metabolism |
| cellular metabolism |
| nucleobase, nucleoside, nucleotide and nucleic acid metabolism |
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