DT-Web

DB01917 - Putrescine


Identification
Name Putrescine
Accession Number DB01917 (EXPT02702)
Type small molecule
Description A toxic diamine formed by putrefaction from the decarboxylation of arginine and ornithine. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 88.1515
Groups experimental
Monoisotopic Weight 88.100048394
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Ornithine decarboxylase
Name Ornithine decarboxylase
Gene Name ODC1
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 1.0303
S-adenosylmethionine decarboxylase proenzyme
Name S-adenosylmethionine decarboxylase proenzyme
Gene Name AMD1
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 1.0095
Putrescine-binding periplasmic protein
Name Putrescine-binding periplasmic protein
Gene Name potF
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.7207

Transporters


Organic cation/carnitine transporter 1
Name Organic cation/carnitine transporter 1
Gene Name SLC22A4
Actions inhibitor
References
  • Yabuuchi H, Tamai I, Nezu J, Sakamoto K, Oku A, Shimane M, Sai Y, Tsuji A: Novel membrane transporter OCTN1 mediates multispecific, bidirectional, and pH-dependent transport of organic cations. J Pharmacol Exp Ther. 1999 May;289(2):768-73. - Pubmed
DTHybrid score 0.3741

Predictions


Id Partner name Gene Name Score
4823 L-allo-threonine aldolase TM_1744 0.0823
2803 Pyridoxine 5'-phosphate synthase pdxJ 0.0793
203 Pyridoxine-5'-phosphate oxidase PNPO 0.0739
118 Organic cation/carnitine transporter 2 SLC22A5 0.0647
3193 Serine hydroxymethyltransferase glyA 0.0645
3342 Serine hydroxymethyltransferase glyA 0.0645
330 Spermidine synthase SRM 0.0527
3038 Spermidine synthase speE 0.0527
6145 Solute carrier family 22 member 1 SLC22A1 0.052
367 Serine hydroxymethyltransferase, cytosolic SHMT1 0.0444
411 Glycine N-methyltransferase GNMT 0.0435
453 S-adenosylmethionine synthetase isoform type-1 MAT1A 0.0429
334 S-adenosylmethionine synthetase isoform type-2 MAT2A 0.0425
4411 DNA protection during starvation protein dps 0.0421
5423 UPF0010 protein HI1317 HI_1317 0.0421
3780 Lipoprotein nlpI precursor nlpI 0.042
5424 Endonuclease VIII-like 1 NEIL1 0.042
358 Cystathionine beta-synthase CBS 0.039
3186 Soluble calcium-activated nucleotidase 1 CANT1 0.0375
3164 Biotin synthase bioB 0.0367
303 Diamine acetyltransferase 2 SAT2 0.0366
1317 Spermine synthase SMS 0.0366
623 Spermine oxidase SMOX 0.0366
123 Diamine acetyltransferase 1 SAT1 0.0365
3583 6-phosphogluconolactonase pgl 0.034
3221 Cytochrome c4 cc4 0.0329
3259 Autolysin lytA 0.0321
6144 Solute carrier family 22 member 2 SLC22A2 0.0301
3810 Catechol O-methyltransferase COMT 0.0293
5492 Cystathionine gamma-synthase metB 0.0273
5491 Methionine gamma-lyase mdeA 0.0273
183 Vascular endothelial growth factor A VEGFA 0.0252
2723 Cholera enterotoxin subunit B ctxB 0.0251
6147 Solute carrier family 22 member 3 SLC22A3 0.0248
6013 Cytochrome P450 2E1 CYP2E1 0.0246
4119 Cytochrome P450 2D6 CYP2D6 0.0245
3947 Xanthine dehydrogenase/oxidase XDH 0.023
2758 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase bioA 0.0215
301 Kynurenine--oxoglutarate transaminase 1 CCBL1 0.02
6142 Solute carrier family 22 member 8 SLC22A8 0.0182
349 Serine--pyruvate aminotransferase AGXT 0.0176
4512 Cytochrome P450 3A4 CYP3A4 0.0173
3704 Spermidine/putrescine-binding periplasmic protein precursor potD 0.0166
2249 Aspartate aminotransferase aspC 0.0158
2671 Aspartate aminotransferase aspC 0.0158
5490 Aspartate aminotransferase Not Available 0.0158
4200 Cytochrome P450 1A2 CYP1A2 0.0148
150 Cationic amino acid transporter 3 SLC7A3 0.0144
235 High-affinity cationic amino acid transporter 1 SLC7A1 0.0144
58 Cationic amino acid transporter 4 SLC7A4 0.0144
3560 Gentamicin 3'-acetyltransferase aacC1 0.0143
1152 Glycogen phosphorylase, muscle form PYGM 0.0139
1588 Multidrug resistance protein 1 ABCB1 0.0132
1729 Solute carrier family 22 member 6 SLC22A6 0.0126
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0124
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0122
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0117
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0115
221 Lysyl-tRNA synthetase KARS 0.0112
477 DNA topoisomerase 4 subunit A parC 0.0106
886 DNA topoisomerase 4 subunit A parC 0.0106
6226 DNA topoisomerase 4 subunit A parC 0.0106
492 Histamine H1 receptor HRH1 0.0104
404 DNA gyrase subunit A gyrA 0.0104
6224 DNA gyrase subunit A gyrA 0.0104
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0102
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0101
619 Low-affinity cationic amino acid transporter 2 SLC7A2 0.0098
817 DNA topoisomerase 2-alpha TOP2A 0.0093
6151 Monocarboxylate transporter 10 SLC16A10 0.0087
499 Arginine decarboxylase ADC 0.0084
2472 Voltage-gated potassium channel kcsA 0.0082
6366 Voltage-gated potassium channel kcsA 0.0082
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0079
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0078
6024 Cytochrome P450 1A1 CYP1A1 0.0078
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0078
1024 Solute carrier family 22 member 11 SLC22A11 0.0074
862 Multidrug resistance-associated protein 1 ABCC1 0.007
6016 Cytochrome P450 2C19 CYP2C19 0.007
220 Sodium channel protein type 5 subunit alpha SCN5A 0.007
6107 Cytochrome P450 3A7 CYP3A7 0.007
4118 Cytochrome P450 3A5 CYP3A5 0.0066
4924 Cytochrome P450 2C8 CYP2C8 0.0065
1064 DNA (cytosine-5)-methyltransferase 1 DNMT1 0.0064
749 Amiloride-sensitive cation channel 1, neuronal ACCN1 0.0064
6030 Cytochrome P450 2B6 CYP2B6 0.0063
5126 Arginase rocF 0.0062
4757 Cytochrome P450 2C9 CYP2C9 0.006
387 Amiloride-sensitive amine oxidase [copper-containing] ABP1 0.0058
7187 Amiloride-sensitive amine oxidase [copper-containing] ABP1 0.0058
827 Sodium/hydrogen exchanger 1 SLC9A1 0.0057
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0056
109 Mitochondrial carnitine/acylcarnitine carrier protein CACL SLC25A29 0.0055
552 Amiloride-sensitive sodium channel subunit gamma SCNN1G 0.0055
213 Amiloride-sensitive sodium channel subunit alpha SCNN1A 0.0055
636 Mitochondrial carnitine/acylcarnitine carrier protein SLC25A20 0.0055
550 Amiloride-sensitive sodium channel subunit delta SCNN1D 0.0055
27 Amiloride-sensitive sodium channel subunit beta SCNN1B 0.0055
577 Argininosuccinate lyase ASL 0.0054
3923 Cholinesterase BCHE 0.0054
834 Arginase-2, mitochondrial ARG2 0.0054
6143 Solute carrier family 22 member 7 SLC22A7 0.0054
624 Guanidinoacetate N-methyltransferase GAMT 0.005
740 Argininosuccinate synthase ASS1 0.0048
865 Argininosuccinate synthase ASS1 0.0048
2680 Argininosuccinate synthase argG 0.0048
3194 Argininosuccinate synthase argG 0.0048
6168 Solute carrier family 22 member 16 SLC22A16 0.0047
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0047
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0047
412 Peroxisomal carnitine O-octanoyltransferase CROT 0.0047
551 Carnitine O-acetyltransferase CRAT 0.0046
976 Platelet glycoprotein IX GP9 0.0044
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0044
6014 Cytochrome P450 2A13 CYP2A13 0.0043
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0043
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0042
776 Bile salt export pump ABCB11 0.004
6432 Transporter snf 0.004
6106 Cytochrome P450 2C18 CYP2C18 0.0039
2300 Lysozyme E 0.0036
3633 Lysozyme R 0.0036
5597 Lysozyme 17 0.0036
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0036
824 Sodium-dependent serotonin transporter SLC6A4 0.0035
3929 Phosphoethanolamine/phosphocholine phosphatase PHOSPHO1 0.0035
549 Choline-phosphate cytidylyltransferase B PCYT1B 0.0035
769 High-affinity choline transporter 1 SLC5A7 0.0035
264 Choline/ethanolamine kinase [Includes: Choline kinase beta CHKB 0.0035
3933 Choline/ethanolaminephosphotransferase CEPT1 0.0035
576 Choline O-acetyltransferase CHAT 0.0035
700 Choline dehydrogenase, mitochondrial CHDH 0.0035
3922 Phospholipase D2 PLD2 0.0035
3927 Choline transporter-like protein 3 SLC44A3 0.0035
1686 Choline transporter-like protein 1 SLC44A1 0.0035
3926 Choline transporter-like protein 2 SLC44A2 0.0035
3925 Choline transporter-like protein 4 SLC44A4 0.0035
861 Choline kinase alpha CHKA 0.0035
3924 Phospholipase D1 PLD1 0.0035
5682 Ribonuclease pancreatic RNASE1 0.0035
1074 Urokinase-type plasminogen activator PLAU 0.0035
7 Nitric oxide synthase, inducible NOS2 0.0034
3906 Serine dehydratase-like SDSL 0.0033
3908 P-selectin cytoplasmic tail-associated protein pcap 0.0033
3915 Cysteine sulfinic acid decarboxylase-related protein 1 CSAD 0.0033
3914 Alanine-glyoxylate aminotransferase homolog TLH6 0.0033
3883 Ornithine aminotransferase variant Not Available 0.0033
306 Pyridoxal phosphate phosphatase PDXP 0.0033
3911 Uncharacterized protein C20orf38 SPTLC3 0.0033
3910 O-phosphoseryl-tRNA(Sec) selenium transferase SEPSECS 0.0033
3891 Putative L-Dopa decarboxylase DDC 0.0033
3909 Hepatic peroxysomal alanine:glyoxylate aminotransferase Not Available 0.0033
3880 Serine hydroxymethyltransferase 1 Not Available 0.0033
3881 Selenocysteine lyase variant Not Available 0.0033
3878 GAD1 protein GAD1 0.0033
3887 Phosphorylase PYGB 0.0033
3893 DDC protein DDC 0.0033
855 Sphingosine-1-phosphate lyase 1 SGPL1 0.0033
3903 Aminolevulinate, delta-, synthase 2 ALAS2 0.0033
664 Glutamate decarboxylase 2 GAD2 0.0033
3890 Glutamate decarboxylase 2 GAD2 0.0033
3896 CDNA FLJ46802 fis, clone TRACH3032150, moderately similar to Cysteine sulfinic acid decarboxylase GADL1 0.0033
3886 Migration-inducing protein 4 ALAS1 0.0033
3894 KIAA0251 protein PDXDC1 0.0033
3875 Glycogen phosphorylase, brain form PYGB 0.0033
3882 Brain glycogen phosphorylase variant Not Available 0.0033
3905 Molybdenum cofactor sulfurase MOCOS 0.0033
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0033
291 Nitric-oxide synthase, endothelial NOS3 0.0033
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0032
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0032
1757 Myeloperoxidase MPO 0.0031
378 Alpha-2C adrenergic receptor ADRA2C 0.0031
4604 Liver carboxylesterase 1 CES1 0.003
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.003
629 Alpha-2B adrenergic receptor ADRA2B 0.003
751 Potassium channel subfamily K member 6 KCNK6 0.0029
3941 Amine oxidase [flavin-containing] A MAOA 0.0028
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0028
738 Monocarboxylate transporter 1 SLC16A1 0.0028
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0028
1360 Sphingomyelin phosphodiesterase SMPD1 0.0028
472 Ornithine aminotransferase, mitochondrial OAT 0.0027
435 Kynureninase KYNU 0.0027
4654 Kynureninase kynU 0.0027
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0027
3913 Glutamic acid decarboxylase GAD65 0.0027
3874 Proline synthetase co-transcribed bacterial homolog protein PROSC 0.0027
801 Kynurenine/alpha-aminoadipate aminotransferase mitochondrial AADAT 0.0027
3895 Kynurenine--oxoglutarate transaminase 3 CCBL2 0.0027
420 Glutamate decarboxylase 1 GAD1 0.0027
3900 Glutamate decarboxylase 1 GAD1 0.0027
665 Phosphoserine aminotransferase PSAT1 0.0027
4652 Phosphoserine aminotransferase serC 0.0027
3 Histidine decarboxylase HDC 0.0027
534 Threonine synthase-like 1 THNSL1 0.0027
575 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial GCAT 0.0027
455 5-aminolevulinate synthase, nonspecific, mitochondrial ALAS1 0.0027
681 Glycine dehydrogenase [decarboxylating], mitochondrial GLDC 0.0027
3899 Alanine--glyoxylate aminotransferase 2-like 2 AGXT2L2 0.0027
184 L-serine dehydratase SDS 0.0027
318 Alpha-2A adrenergic receptor ADRA2A 0.0027
491 Serine palmitoyltransferase 1 SPTLC1 0.0027
727 Serine palmitoyltransferase 2 SPTLC2 0.0027
431 Serine racemase SRR 0.0027
89 Cysteine sulfinic acid decarboxylase CSAD 0.0027
868 Cystathionine gamma-lyase CTH 0.0027
172 Potassium channel subfamily K member 1 KCNK1 0.0026
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0026
426 Aspartate aminotransferase, mitochondrial GOT2 0.0025
914 Formimidoyltransferase-cyclodeaminase FTCD 0.0025
3877 Growth-inhibiting protein 18 GIG18 0.0024
169 Cysteine desulfurase, mitochondrial NFS1 0.0024
3884 SHMT2 protein SHMT2 0.0024
3901 SHMT2 protein SHMT2 0.0024
3885 Hypothetical protein DKFZp686P09201 DKFZp686P09201 0.0024
3879 Serine hydroxymethyltransferase 2 Not Available 0.0024
321 Serine hydroxymethyltransferase, mitochondrial SHMT2 0.0024
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0024
502 5-hydroxytryptamine 2A receptor HTR2A 0.0024
795 Branched-chain-amino-acid aminotransferase, mitochondrial BCAT2 0.0024
10 Glycogen phosphorylase, liver form PYGL 0.0023
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0023
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0023
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0023
586 Aspartate aminotransferase, cytoplasmic GOT1 0.0023
556 Alpha-1A adrenergic receptor ADRA1A 0.0023
5718 Cytochrome P450 2A6 CYP2A6 0.0023
735 Alanine aminotransferase 1 GPT 0.0023
3904 Alanine aminotransferase 2 GPT2 0.0023
763 Tyrosine aminotransferase TAT 0.0023
5493 Tyrosine aminotransferase Not Available 0.0023
114 Alanine--glyoxylate aminotransferase 2, mitochondrial AGXT2 0.0022
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0022
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0022
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0021
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0021
574 Branched-chain-amino-acid aminotransferase, cytosolic BCAT1 0.0021
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.002
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.002
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.002
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.002
3876 Aromatic-L-amino-acid decarboxylase DDC 0.002
124 Histamine H2 receptor HRH2 0.0019
6031 Cytochrome P450 3A43 CYP3A43 0.0018
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0018
756 Sex hormone-binding globulin SHBG 0.0018
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0018
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0018
6141 Sodium/bile acid cotransporter SLC10A1 0.0017
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0017
474 Acetylcholinesterase ACHE 0.0017
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0015
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0015
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0015
1898 Cytochrome P450 1B1 CYP1B1 0.0015
789 Alpha-1D adrenergic receptor ADRA1D 0.0015
146 Androgen receptor AR 0.0015
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0014
3811 Cytochrome P450 19A1 CYP19A1 0.0014
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0014
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0014
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0014
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0014
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0014
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0014
3939 Amine oxidase [flavin-containing] B MAOB 0.0013
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0013
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0013
193 Beta-1 adrenergic receptor ADRB1 0.0013
766 Beta-2 adrenergic receptor ADRB2 0.0013
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0012
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0012
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0012
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0011
587 Serum albumin ALB 0.0011
6148 Multidrug resistance-associated protein 7 ABCC10 0.0011
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.001
2164 Multidrug resistance-associated protein 4 ABCC4 0.0009
↑