DT-Web

DB02824 - N-Pyridoxyl-Glycine-5-Monophosphate


Identification
Name N-Pyridoxyl-Glycine-5-Monophosphate
Accession Number DB02824 (EXPT02606)
Type small molecule
Description Not Available
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 306.2091
Groups experimental
Monoisotopic Weight 306.061687356
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


L-allo-threonine aldolase
Name L-allo-threonine aldolase
Gene Name TM_1744
Pharmacological action unknown
Actions Not Available
References Not Available
DTHybrid score 1.232
Serine hydroxymethyltransferase
Name Serine hydroxymethyltransferase
Gene Name glyA
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 1.0336
Serine hydroxymethyltransferase, cytosolic
Name Serine hydroxymethyltransferase, cytosolic
Gene Name SHMT1
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 0.7771
Ornithine decarboxylase
Name Ornithine decarboxylase
Gene Name ODC1
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 1.0224

Predictions


Id Partner name Gene Name Score
3193 Serine hydroxymethyltransferase glyA 1.0336
365 Dihydrofolate reductase DHFR 0.3315
2381 Dihydrofolate reductase DFR1 0.3315
2833 Dihydrofolate reductase Not Available 0.3315
2931 Dihydrofolate reductase folA 0.3315
3544 Dihydrofolate reductase folA 0.3315
3682 Dihydrofolate reductase folA 0.3315
6642 Dihydrofolate reductase folA 0.3315
6756 Dihydrofolate reductase dfrA 0.3315
3470 Hypothetical protein MG245 homolog MPN_348 0.1428
5492 Cystathionine gamma-synthase metB 0.0917
5491 Methionine gamma-lyase mdeA 0.0916
2803 Pyridoxine 5'-phosphate synthase pdxJ 0.0793
203 Pyridoxine-5'-phosphate oxidase PNPO 0.0768
2429 Putrescine-binding periplasmic protein potF 0.0732
2758 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase bioA 0.0731
1649 Small inducible cytokine A2 CCL2 0.069
301 Kynurenine--oxoglutarate transaminase 1 CCBL1 0.0638
349 Serine--pyruvate aminotransferase AGXT 0.0615
279 Tyrosinase TYR 0.0592
2249 Aspartate aminotransferase aspC 0.0532
2671 Aspartate aminotransferase aspC 0.0532
5490 Aspartate aminotransferase Not Available 0.0532
113 S-adenosylmethionine decarboxylase proenzyme AMD1 0.0511
1152 Glycogen phosphorylase, muscle form PYGM 0.045
833 Organic cation/carnitine transporter 1 SLC22A4 0.0418
123 Diamine acetyltransferase 1 SAT1 0.0278
303 Diamine acetyltransferase 2 SAT2 0.027
1317 Spermine synthase SMS 0.027
623 Spermine oxidase SMOX 0.027
3885 Hypothetical protein DKFZp686P09201 DKFZp686P09201 0.0232
3879 Serine hydroxymethyltransferase 2 Not Available 0.0232
321 Serine hydroxymethyltransferase, mitochondrial SHMT2 0.0232
3884 SHMT2 protein SHMT2 0.023
3901 SHMT2 protein SHMT2 0.023
914 Formimidoyltransferase-cyclodeaminase FTCD 0.0159
3947 Xanthine dehydrogenase/oxidase XDH 0.0147
3920 Methylenetetrahydrofolate reductase intermediate form MTHFR 0.0141
3919 Methionyl-tRNA formyltransferase, mitochondrial MTFMT 0.0141
3763 5,10-methylenetetrahydrofolate reductase metF 0.0141
3918 5,10-methylenetetrahydrofolate reductase MTHFR 0.0141
5094 5,10-methylenetetrahydrofolate reductase metF 0.0141
59 AMT protein AMT 0.0141
1202 10-formyltetrahydrofolate dehydrogenase ALDH1L1 0.0141
455 5-aminolevulinate synthase, nonspecific, mitochondrial ALAS1 0.012
575 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial GCAT 0.012
681 Glycine dehydrogenase [decarboxylating], mitochondrial GLDC 0.012
6145 Solute carrier family 22 member 1 SLC22A1 0.0113
296 Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial MTHFD2 0.0112
13 Aminomethyltransferase, mitochondrial AMT 0.0111
679 C-1-tetrahydrofolate synthase, cytoplasmic MTHFD1 0.0103
114 Alanine--glyoxylate aminotransferase 2, mitochondrial AGXT2 0.0101
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0094
809 Methionine synthase MTR 0.0094
2935 Methionine synthase metH 0.0094
3917 Methylenetetrahydrofolate reductase MTHFR 0.008
3880 Serine hydroxymethyltransferase 1 Not Available 0.0077
4058 Glycine N-acyltransferase-like protein 2 GLYATL2 0.0071
4057 Glycine N-acyltransferase GLYAT 0.0071
4059 Glycine N-acyltransferase-like protein 1 GLYATL1 0.0071
1466 Glycyl-tRNA synthetase GARS 0.0071
4056 N-arachidonyl glycine receptor GPR18 0.0071
4062 Sodium- and chloride-dependent glycine transporter 2 SLC6A5 0.0071
4061 Peroxisomal sarcosine oxidase PIPOX 0.0071
4055 Bile acid CoA:amino acid N-acyltransferase BAAT 0.0071
1236 Sodium- and chloride-dependent glycine transporter 1 SLC6A9 0.0071
4060 Vesicular inhibitory amino acid transporter SLC32A1 0.0071
1088 5-aminolevulinate synthase, erythroid-specific, mitochondrial ALAS2 0.0071
3911 Uncharacterized protein C20orf38 SPTLC3 0.0069
306 Pyridoxal phosphate phosphatase PDXP 0.0069
3908 P-selectin cytoplasmic tail-associated protein pcap 0.0069
3915 Cysteine sulfinic acid decarboxylase-related protein 1 CSAD 0.0069
3914 Alanine-glyoxylate aminotransferase homolog TLH6 0.0069
3883 Ornithine aminotransferase variant Not Available 0.0069
3906 Serine dehydratase-like SDSL 0.0069
3881 Selenocysteine lyase variant Not Available 0.0069
3887 Phosphorylase PYGB 0.0069
3891 Putative L-Dopa decarboxylase DDC 0.0069
3909 Hepatic peroxysomal alanine:glyoxylate aminotransferase Not Available 0.0069
3910 O-phosphoseryl-tRNA(Sec) selenium transferase SEPSECS 0.0069
3878 GAD1 protein GAD1 0.0069
3896 CDNA FLJ46802 fis, clone TRACH3032150, moderately similar to Cysteine sulfinic acid decarboxylase GADL1 0.0069
664 Glutamate decarboxylase 2 GAD2 0.0069
3890 Glutamate decarboxylase 2 GAD2 0.0069
3893 DDC protein DDC 0.0069
3886 Migration-inducing protein 4 ALAS1 0.0069
855 Sphingosine-1-phosphate lyase 1 SGPL1 0.0069
3903 Aminolevulinate, delta-, synthase 2 ALAS2 0.0069
3894 KIAA0251 protein PDXDC1 0.0069
3875 Glycogen phosphorylase, brain form PYGB 0.0069
3882 Brain glycogen phosphorylase variant Not Available 0.0069
3905 Molybdenum cofactor sulfurase MOCOS 0.0069
4054 Glycine cleavage system H protein, mitochondrial GCSH 0.0063
499 Arginine decarboxylase ADC 0.0057
3899 Alanine--glyoxylate aminotransferase 2-like 2 AGXT2L2 0.0057
801 Kynurenine/alpha-aminoadipate aminotransferase mitochondrial AADAT 0.0057
62 Glycine receptor subunit beta GLRB 0.0057
3895 Kynurenine--oxoglutarate transaminase 3 CCBL2 0.0057
665 Phosphoserine aminotransferase PSAT1 0.0057
4652 Phosphoserine aminotransferase serC 0.0057
435 Kynureninase KYNU 0.0057
4654 Kynureninase kynU 0.0057
184 L-serine dehydratase SDS 0.0057
420 Glutamate decarboxylase 1 GAD1 0.0057
3900 Glutamate decarboxylase 1 GAD1 0.0057
3874 Proline synthetase co-transcribed bacterial homolog protein PROSC 0.0057
431 Serine racemase SRR 0.0057
491 Serine palmitoyltransferase 1 SPTLC1 0.0057
534 Threonine synthase-like 1 THNSL1 0.0057
727 Serine palmitoyltransferase 2 SPTLC2 0.0057
89 Cysteine sulfinic acid decarboxylase CSAD 0.0057
3 Histidine decarboxylase HDC 0.0057
3913 Glutamic acid decarboxylase GAD65 0.0057
411 Glycine N-methyltransferase GNMT 0.0057
472 Ornithine aminotransferase, mitochondrial OAT 0.0056
383 Glycine amidinotransferase, mitochondrial GATM 0.0055
207 Glutathione synthetase GSS 0.0055
5269 Glutathione synthetase gshB 0.0055
868 Cystathionine gamma-lyase CTH 0.0054
426 Aspartate aminotransferase, mitochondrial GOT2 0.0052
169 Cysteine desulfurase, mitochondrial NFS1 0.0052
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0052
3877 Growth-inhibiting protein 18 GIG18 0.0051
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.005
358 Cystathionine beta-synthase CBS 0.005
593 Proton-coupled amino acid transporter 1 SLC36A1 0.005
795 Branched-chain-amino-acid aminotransferase, mitochondrial BCAT2 0.0048
735 Alanine aminotransferase 1 GPT 0.0048
586 Aspartate aminotransferase, cytoplasmic GOT1 0.0048
3904 Alanine aminotransferase 2 GPT2 0.0048
763 Tyrosine aminotransferase TAT 0.0048
5493 Tyrosine aminotransferase Not Available 0.0048
461 Glycine receptor subunit alpha-3 GLRA3 0.0048
820 Glycine receptor subunit alpha-2 GLRA2 0.0048
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0047
10 Glycogen phosphorylase, liver form PYGL 0.0046
574 Branched-chain-amino-acid aminotransferase, cytosolic BCAT1 0.0044
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0044
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0043
482 Glycine receptor subunit alpha-1 GLRA1 0.0042
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0042
6151 Monocarboxylate transporter 10 SLC16A10 0.0036
↑