DT-Web

DB00116 - Tetrahydrofolic acid


Identification
Name Tetrahydrofolic acid
Accession Number DB00116 (NUTR00056)
Type small molecule
Description Tetrahydrofolic acid is a folic acid derivative. It is produced from dihydrofolic acid by dihydrofolate reductase. It is converted into 5,10-methylenetetrahydrofolate by serine hydroxymethyltransferase. It is a coenzyme in many reactions, especially in the metabolism of amino acids and nucleic acids. It acts as a donor of a group with one carbon atom. It gets this carbon atom by sequestering formaldehyde produced in other processes.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 445.4292
Groups approved
Monoisotopic Weight 445.170981503
Pharmacology
Indication For nutritional supplementation, also for treating dietary shortage or imbalance.
Mechanism of action Tetrahydrofolate is transported across cells by receptor-mediated endocytosis where it is needed to maintain normal erythropoiesis, synthesize purine and thymidylate nucleic acids, interconvert amino acids, methylate tRNA, and generate and use formate.
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


C-1-tetrahydrofolate synthase, cytoplasmic
Name C-1-tetrahydrofolate synthase, cytoplasmic
Gene Name MTHFD1
Pharmacological action unknown
Actions cofactor
References
  • Akar N, Akar E, Ozel D, Deda G, Sipahi T: Common mutations at the homocysteine metabolism pathway and pediatric stroke. Thromb Res. 2001 Apr 15;102(2):115-20. - Pubmed
  • Walkup AS, Appling DR: Enzymatic characterization of human mitochondrial C1-tetrahydrofolate synthase. Arch Biochem Biophys. 2005 Oct 15;442(2):196-205. Epub 2005 Aug 30. - Pubmed
  • Matakidou A, El Galta R, Rudd MF, Webb EL, Bridle H, Eisen T, Houlston RS: Prognostic significance of folate metabolism polymorphisms for lung cancer. Br J Cancer. 2007 Jul 16;97(2):247-52. Epub 2007 May 29. - Pubmed
  • Salmassi TM, Leadbetter JR: Analysis of genes of tetrahydrofolate-dependent metabolism from cultivated spirochaetes and the gut community of the termite Zootermopsis angusticollis. Microbiology. 2003 Sep;149(Pt 9):2529-37. - Pubmed
  • Prasannan P, Pike S, Peng K, Shane B, Appling DR: Human mitochondrial C1-tetrahydrofolate synthase: gene structure, tissue distribution of the mRNA, and immunolocalization in Chinese hamster ovary calls. J Biol Chem. 2003 Oct 31;278(44):43178-87. Epub 2003 Aug 22. - Pubmed
DTHybrid score 1.1539
Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial
Name Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial
Gene Name MTHFD2
Pharmacological action unknown
Actions cofactor
References
  • Salmassi TM, Leadbetter JR: Analysis of genes of tetrahydrofolate-dependent metabolism from cultivated spirochaetes and the gut community of the termite Zootermopsis angusticollis. Microbiology. 2003 Sep;149(Pt 9):2529-37. - Pubmed
DTHybrid score 0.593
Aminomethyltransferase, mitochondrial
Name Aminomethyltransferase, mitochondrial
Gene Name AMT
Pharmacological action unknown
Actions cofactor
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Masai E, Sasaki M, Minakawa Y, Abe T, Sonoki T, Miyauchi K, Katayama Y, Fukuda M: A novel tetrahydrofolate-dependent O-demethylase gene is essential for growth of Sphingomonas paucimobilis SYK-6 with syringate. J Bacteriol. 2004 May;186(9):2757-65. - Pubmed
DTHybrid score 0.8845
AMT protein
Name AMT protein
Gene Name AMT
Pharmacological action unknown
Actions cofactor
References
  • Lee HH, Kim DJ, Ahn HJ, Ha JY, Suh SW: Crystal structure of T-protein of the glycine cleavage system. Cofactor binding, insights into H-protein recognition, and molecular basis for understanding nonketotic hyperglycinemia. J Biol Chem. 2004 Nov 26;279(48):50514-23. Epub 2004 Sep 7. - Pubmed
  • Masai E, Sasaki M, Minakawa Y, Abe T, Sonoki T, Miyauchi K, Katayama Y, Fukuda M: A novel tetrahydrofolate-dependent O-demethylase gene is essential for growth of Sphingomonas paucimobilis SYK-6 with syringate. J Bacteriol. 2004 May;186(9):2757-65. - Pubmed
  • Scrutton NS, Leys D: Crystal structure of DMGO provides a prototype for a new tetrahydrofolate-binding fold. Biochem Soc Trans. 2005 Aug;33(Pt 4):776-9. - Pubmed
  • Gangjee A, Kurup S, Namjoshi O: Dihydrofolate reductase as a target for chemotherapy in parasites. Curr Pharm Des. 2007;13(6):609-39. - Pubmed
DTHybrid score 0.7866
10-formyltetrahydrofolate dehydrogenase
Name 10-formyltetrahydrofolate dehydrogenase
Gene Name ALDH1L1
Pharmacological action unknown
Actions cofactor
References
  • Fu TF, Maras B, Barra D, Schirch V: A noncatalytic tetrahydrofolate tight binding site is on the small domain of 10-formyltetrahydrofolate dehydrogenase. Arch Biochem Biophys. 1999 Jul 15;367(2):161-6. - Pubmed
  • Krupenko SA, Wagner C: Aspartate 142 is involved in both hydrolase and dehydrogenase catalytic centers of 10-formyltetrahydrofolate dehydrogenase. J Biol Chem. 1999 Dec 10;274(50):35777-84. - Pubmed
  • Krupenko SA, Vlasov AP, Wagner C: On the role of conserved histidine 106 in 10-formyltetrahydrofolate dehydrogenase catalysis: connection between hydrolase and dehydrogenase mechanisms. J Biol Chem. 2001 Jun 29;276(26):24030-7. Epub 2001 Apr 24. - Pubmed
  • Anguera MC, Field MS, Perry C, Ghandour H, Chiang EP, Selhub J, Shane B, Stover PJ: Regulation of folate-mediated one-carbon metabolism by 10-formyltetrahydrofolate dehydrogenase. J Biol Chem. 2006 Jul 7;281(27):18335-42. Epub 2006 Apr 20. - Pubmed
  • Oleinik NV, Krupenko NI, Reuland SN, Krupenko SA: Leucovorin-induced resistance against FDH growth suppressor effects occurs through DHFR up-regulation. Biochem Pharmacol. 2006 Jul 14;72(2):256-66. Epub 2006 Apr 25. - Pubmed
DTHybrid score 0.7801
Methionine synthase
Name Methionine synthase
Gene Name MTR
Pharmacological action unknown
Actions cofactor
References
  • Hall DA, Jordan-Starck TC, Loo RO, Ludwig ML, Matthews RG: Interaction of flavodoxin with cobalamin-dependent methionine synthase. Biochemistry. 2000 Sep 5;39(35):10711-9. - Pubmed
  • Fowler B: The folate cycle and disease in humans. Kidney Int Suppl. 2001 Feb;78:S221-9. - Pubmed
  • Fu TF, di Salvo M, Schirch V: Enzymatic determination of homocysteine in cell extracts. Anal Biochem. 2001 Mar;290(2):359-65. - Pubmed
  • Jarrett JT, Choi CY, Matthews RG: Changes in protonation associated with substrate binding and Cob(I)alamin formation in cobalamin-dependent methionine synthase. Biochemistry. 1997 Dec 16;36(50):15739-48. - Pubmed
  • Jarrett JT, Hoover DM, Ludwig ML, Matthews RG: The mechanism of adenosylmethionine-dependent activation of methionine synthase: a rapid kinetic analysis of intermediates in reductive methylation of Cob(II)alamin enzyme. Biochemistry. 1998 Sep 8;37(36):12649-58. - Pubmed
DTHybrid score 0.5774
Formimidoyltransferase-cyclodeaminase
Name Formimidoyltransferase-cyclodeaminase
Gene Name FTCD
Pharmacological action unknown
Actions cofactor
References
  • Bashour AM, Bloom GS: 58K, a microtubule-binding Golgi protein, is a formiminotransferase cyclodeaminase. J Biol Chem. 1998 Jul 31;273(31):19612-7. - Pubmed
  • Cook RJ: Disruption of histidine catabolism in NEUT2 mice. Arch Biochem Biophys. 2001 Aug 15;392(2):226-32. - Pubmed
  • Kohls D, Croteau N, Mejia N, MacKenzie RE, Vrielink A: Crystallization and preliminary X-ray analysis of the formiminotransferase domain from the bifunctional enzyme formiminotransferase-cyclodeaminase. Acta Crystallogr D Biol Crystallogr. 1999 Jun;55(Pt 6):1206-8. - Pubmed
  • Kohls D, Sulea T, Purisima EO, MacKenzie RE, Vrielink A: The crystal structure of the formiminotransferase domain of formiminotransferase-cyclodeaminase: implications for substrate channeling in a bifunctional enzyme. Structure. 2000 Jan 15;8(1):35-46. - Pubmed
DTHybrid score 0.632
Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase
Name Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase
Gene Name ATIC
Pharmacological action unknown
Actions cofactor
References
  • Wolan DW, Greasley SE, Wall MJ, Benkovic SJ, Wilson IA: Structure of avian AICAR transformylase with a multisubstrate adduct inhibitor beta-DADF identifies the folate binding site. Biochemistry. 2003 Sep 23;42(37):10904-14. - Pubmed
  • Bulock KG, Beardsley GP, Anderson KS: The kinetic mechanism of the human bifunctional enzyme ATIC (5-amino-4-imidazolecarboxamide ribonucleotide transformylase/inosine 5'-monophosphate cyclohydrolase). A surprising lack of substrate channeling. J Biol Chem. 2002 Jun 21;277(25):22168-74. Epub 2002 Apr 10. - Pubmed
DTHybrid score 1.2034
Serine hydroxymethyltransferase, cytosolic
Name Serine hydroxymethyltransferase, cytosolic
Gene Name SHMT1
Pharmacological action unknown
Actions cofactor
References
  • Scarsdale JN, Radaev S, Kazanina G, Schirch V, Wright HT: Crystal structure at 2.4 A resolution of E. coli serine hydroxymethyltransferase in complex with glycine substrate and 5-formyl tetrahydrofolate. J Mol Biol. 2000 Feb 11;296(1):155-68. - Pubmed
  • Rao JV, Prakash V, Rao NA, Savithri HS: The role of Glu74 and Tyr82 in the reaction catalyzed by sheep liver cytosolic serine hydroxymethyltransferase. Eur J Biochem. 2000 Oct;267(19):5967-76. - Pubmed
  • Heil SG, Van der Put NM, Waas ET, den Heijer M, Trijbels FJ, Blom HJ: Is mutated serine hydroxymethyltransferase (SHMT) involved in the etiology of neural tube defects? Mol Genet Metab. 2001 Jun;73(2):164-72. - Pubmed
  • Ravanel S, Cherest H, Jabrin S, Grunwald D, Surdin-Kerjan Y, Douce R, Rebeille F: Tetrahydrofolate biosynthesis in plants: molecular and functional characterization of dihydrofolate synthetase and three isoforms of folylpolyglutamate synthetase in Arabidopsis thaliana. Proc Natl Acad Sci U S A. 2001 Dec 18;98(26):15360-5. - Pubmed
  • Li R, Moore M, King J: Investigating the regulation of one-carbon metabolism in Arabidopsis thaliana. Plant Cell Physiol. 2003 Mar;44(3):233-41. - Pubmed
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 0.9984
Serine hydroxymethyltransferase, mitochondrial
Name Serine hydroxymethyltransferase, mitochondrial
Gene Name SHMT2
Pharmacological action unknown
Actions cofactor
References
  • Heil SG, Van der Put NM, Waas ET, den Heijer M, Trijbels FJ, Blom HJ: Is mutated serine hydroxymethyltransferase (SHMT) involved in the etiology of neural tube defects? Mol Genet Metab. 2001 Jun;73(2):164-72. - Pubmed
  • Contestabile R, Paiardini A, Pascarella S, di Salvo ML, D'Aguanno S, Bossa F: l-Threonine aldolase, serine hydroxymethyltransferase and fungal alanine racemase. A subgroup of strictly related enzymes specialized for different functions. Eur J Biochem. 2001 Dec;268(24):6508-25. - Pubmed
  • Li R, Moore M, King J: Investigating the regulation of one-carbon metabolism in Arabidopsis thaliana. Plant Cell Physiol. 2003 Mar;44(3):233-41. - Pubmed
  • Appaji Rao N, Ambili M, Jala VR, Subramanya HS, Savithri HS: Structure-function relationship in serine hydroxymethyltransferase. Biochim Biophys Acta. 2003 Apr 11;1647(1-2):24-9. - Pubmed
  • Angelaccio S, Chiaraluce R, Consalvi V, Buchenau B, Giangiacomo L, Bossa F, Contestabile R: Catalytic and thermodynamic properties of tetrahydromethanopterin-dependent serine hydroxymethyltransferase from Methanococcus jannaschii. J Biol Chem. 2003 Oct 24;278(43):41789-97. Epub 2003 Aug 5. - Pubmed
DTHybrid score 0.6531
Methylenetetrahydrofolate reductase
Name Methylenetetrahydrofolate reductase
Gene Name MTHFR
Pharmacological action unknown
Actions cofactor
References
  • Ubbink JB, Christianson A, Bester MJ, Van Allen MI, Venter PA, Delport R, Blom HJ, van der Merwe A, Potgieter H, Vermaak WJ: Folate status, homocysteine metabolism, and methylene tetrahydrofolate reductase genotype in rural South African blacks with a history of pregnancy complicated by neural tube defects. Metabolism. 1999 Feb;48(2):269-74. - Pubmed
  • Heijmans BT, Gussekloo J, Kluft C, Droog S, Lagaay AM, Knook DL, Westendorp RG, Slagboom EP: Mortality risk in men is associated with a common mutation in the methylene-tetrahydrofolate reductase gene (MTHFR). Eur J Hum Genet. 1999 Feb-Mar;7(2):197-204. - Pubmed
  • Tsai MY, Welge BG, Hanson NQ, Bignell MK, Vessey J, Schwichtenberg K, Yang F, Bullemer FE, Rasmussen R, Graham KJ: Genetic causes of mild hyperhomocysteinemia in patients with premature occlusive coronary artery diseases. Atherosclerosis. 1999 Mar;143(1):163-70. - Pubmed
  • Holmes ZR, Regan L, Chilcott I, Cohen H: The C677T MTHFR gene mutation is not predictive of risk for recurrent fetal loss. Br J Haematol. 1999 Apr;105(1):98-101. - Pubmed
  • Larsson J, Hultberg B, Hillarp A: Hyperhomocysteinemia and the MTHFR C677T mutation in central retinal vein occlusion. Acta Ophthalmol Scand. 2000 Jun;78(3):340-3. - Pubmed
DTHybrid score 0.5617
Serine hydroxymethyltransferase 2
Name Serine hydroxymethyltransferase 2
Gene Name Not Available
Pharmacological action unknown
Actions cofactor
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Chang WN, Tsai JN, Chen BH, Huang HS, Fu TF: Serine hydroxymethyltransferase isoforms are differentially inhibited by leucovorin-Characterization and comparison of recombinant zebrafish serine hydroxymethyltransferases. Drug Metab Dispos. 2007 Jul 30;. - Pubmed
DTHybrid score 0.653
SHMT2 protein
Name SHMT2 protein
Gene Name SHMT2
Pharmacological action unknown
Actions cofactor
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.648
Hypothetical protein DKFZp686P09201
Name Hypothetical protein DKFZp686P09201
Gene Name DKFZp686P09201
Pharmacological action unknown
Actions cofactor
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.6528
5,10-methylenetetrahydrofolate reductase
Name 5,10-methylenetetrahydrofolate reductase
Gene Name MTHFR
Pharmacological action unknown
Actions cofactor
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Siva A, De Lange M, Clayton D, Monteith S, Spector T, Brown MJ: The heritability of plasma homocysteine, and the influence of genetic variation in the homocysteine methylation pathway. QJM. 2007 Aug;100(8):495-9. Epub 2007 Jul 17. - Pubmed
  • Leopardi P, Marcon F, Caiola S, Cafolla A, Siniscalchi E, Zijno A, Crebelli R: Effects of folic acid deficiency and MTHFR C677T polymorphism on spontaneous and radiation-induced micronuclei in human lymphocytes. Mutagenesis. 2006 Sep;21(5):327-33. Epub 2006 Sep 1. - Pubmed
  • Ott K, Vogelsang H, Marton N, Becker K, Lordick F, Kobl M, Schuhmacher C, Novotny A, Mueller J, Fink U, Ulm K, Siewert JR, Hofler H, Keller G: The thymidylate synthase tandem repeat promoter polymorphism: A predictor for tumor-related survival in neoadjuvant treated locally advanced gastric cancer. Int J Cancer. 2006 Dec 15;119(12):2885-94. - Pubmed
DTHybrid score 0.7919
SHMT2 protein
Name SHMT2 protein
Gene Name SHMT2
Pharmacological action unknown
Actions cofactor
References
  • Prabhu V, Chatson KB, Lui H, Abrams GD, King J: Effects of sulfanilamide and methotrexate on 13C fluxes through the glycine decarboxylase/serine hydroxymethyltransferase enzyme system in arabidopsis. Plant Physiol. 1998 Jan;116(1):137-44. - Pubmed
  • Heil SG, Van der Put NM, Waas ET, den Heijer M, Trijbels FJ, Blom HJ: Is mutated serine hydroxymethyltransferase (SHMT) involved in the etiology of neural tube defects? Mol Genet Metab. 2001 Jun;73(2):164-72. - Pubmed
  • Rajaram V, Bhavani BS, Kaul P, Prakash V, Appaji Rao N, Savithri HS, Murthy MR: Structure determination and biochemical studies on Bacillus stearothermophilus E53Q serine hydroxymethyltransferase and its complexes provide insights on function and enzyme memory. FEBS J. 2007 Aug;274(16):4148-60. Epub 2007 Jul 25. - Pubmed
  • Contestabile R, Paiardini A, Pascarella S, di Salvo ML, D'Aguanno S, Bossa F: l-Threonine aldolase, serine hydroxymethyltransferase and fungal alanine racemase. A subgroup of strictly related enzymes specialized for different functions. Eur J Biochem. 2001 Dec;268(24):6508-25. - Pubmed
  • Vatsyayan R, Roy U: Molecular cloning and biochemical characterization of Leishmania donovani serine hydroxymethyltransferase. Protein Expr Purif. 2007 Apr;52(2):433-40. Epub 2006 Oct 26. - Pubmed
DTHybrid score 0.648
Methionyl-tRNA formyltransferase, mitochondrial
Name Methionyl-tRNA formyltransferase, mitochondrial
Gene Name MTFMT
Pharmacological action unknown
Actions cofactor
References
  • Li Y, Holmes WB, Appling DR, RajBhandary UL: Initiation of protein synthesis in Saccharomyces cerevisiae mitochondria without formylation of the initiator tRNA. J Bacteriol. 2000 May;182(10):2886-92. - Pubmed
DTHybrid score 0.7804
Methylenetetrahydrofolate reductase intermediate form
Name Methylenetetrahydrofolate reductase intermediate form
Gene Name MTHFR
Pharmacological action unknown
Actions cofactor
References
  • Dilley A, Hooper WC, El-Jamil M, Renshaw M, Wenger NK, Evatt BL: Mutations in the genes regulating methylene tetrahydrofolate reductase (MTHFR C-->T677) and cystathione beta-synthase (CBS G-->A919, CBS T-->c833) are not associated with myocardial infarction in African Americans. Thromb Res. 2001 Jul 15;103(2):109-15. - Pubmed
  • Huang L, Zhang J, Hayakawa T, Tsuge H: Assays of methylenetetrahydrofolate reductase and methionine synthase activities by monitoring 5-methyltetrahydrofolate and tetrahydrofolate using high-performance liquid chromatography with fluorescence detection. Anal Biochem. 2001 Dec 15;299(2):253-9. - Pubmed
  • Heijmans BT, Gussekloo J, Kluft C, Droog S, Lagaay AM, Knook DL, Westendorp RG, Slagboom EP: Mortality risk in men is associated with a common mutation in the methylene-tetrahydrofolate reductase gene (MTHFR). Eur J Hum Genet. 1999 Feb-Mar;7(2):197-204. - Pubmed
  • Tsai AW, Cushman M, Tsai MY, Heckbert SR, Rosamond WD, Aleksic N, Yanez ND, Psaty BM, Folsom AR: Serum homocysteine, thermolabile variant of methylene tetrahydrofolate reductase (MTHFR), and venous thromboembolism: Longitudinal Investigation of Thromboembolism Etiology (LITE). Am J Hematol. 2003 Mar;72(3):192-200. - Pubmed
  • Larsson J, Hultberg B, Hillarp A: Hyperhomocysteinemia and the MTHFR C677T mutation in central retinal vein occlusion. Acta Ophthalmol Scand. 2000 Jun;78(3):340-3. - Pubmed
DTHybrid score 0.7917

Transporters


Canalicular multispecific organic anion transporter 1
Name Canalicular multispecific organic anion transporter 1
Gene Name ABCC2
Actions inhibitor
References
  • Kusuhara H, Han YH, Shimoda M, Kokue E, Suzuki H, Sugiyama Y: Reduced folate derivatives are endogenous substrates for cMOAT in rats. Am J Physiol. 1998 Oct;275(4 Pt 1):G789-96. - Pubmed
DTHybrid score 0.4781

Predictions


Id Partner name Gene Name Score
3763 5,10-methylenetetrahydrofolate reductase metF 0.7919
5094 5,10-methylenetetrahydrofolate reductase metF 0.7919
2935 Methionine synthase metH 0.5774
3470 Hypothetical protein MG245 homolog MPN_348 0.1428
840 Methionine synthase reductase, mitochondrial MTRR 0.1114
455 5-aminolevulinate synthase, nonspecific, mitochondrial ALAS1 0.1103
575 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial GCAT 0.1103
681 Glycine dehydrogenase [decarboxylating], mitochondrial GLDC 0.1102
3193 Serine hydroxymethyltransferase glyA 0.0922
3342 Serine hydroxymethyltransferase glyA 0.0922
114 Alanine--glyoxylate aminotransferase 2, mitochondrial AGXT2 0.092
507 Cob(I)yrinic acid a,c-diamide adenosyltransferase, mitochondrial MMAB 0.0894
3916 Methylmalonic aciduria and homocystinuria type C protein MMACHC 0.0894
398 Transcobalamin-2 TCN2 0.0894
354 Methylmalonic aciduria type A protein, mitochondrial MMAA 0.0894
265 Transcobalamin-1 TCN1 0.0894
376 Amnionless protein AMN 0.0894
854 Methylmalonyl-CoA mutase, mitochondrial MUT 0.0894
1224 Cubilin CUBN 0.0893
349 Serine--pyruvate aminotransferase AGXT 0.083
4061 Peroxisomal sarcosine oxidase PIPOX 0.0816
4058 Glycine N-acyltransferase-like protein 2 GLYATL2 0.0816
4057 Glycine N-acyltransferase GLYAT 0.0816
4059 Glycine N-acyltransferase-like protein 1 GLYATL1 0.0816
4056 N-arachidonyl glycine receptor GPR18 0.0816
4062 Sodium- and chloride-dependent glycine transporter 2 SLC6A5 0.0816
4055 Bile acid CoA:amino acid N-acyltransferase BAAT 0.0816
1466 Glycyl-tRNA synthetase GARS 0.0816
1236 Sodium- and chloride-dependent glycine transporter 1 SLC6A9 0.0815
1088 5-aminolevulinate synthase, erythroid-specific, mitochondrial ALAS2 0.0815
4060 Vesicular inhibitory amino acid transporter SLC32A1 0.0815
87 Hypoxanthine-guanine phosphoribosyltransferase HPRT1 0.0809
3082 Aminomethyltransferase gcvT 0.0762
3257 Bifunctional polymyxin resistance protein arnA arnA 0.075
5072 N,N-dimethylglycine oxidase dmg 0.0747
449 Ornithine decarboxylase ODC1 0.0734
1649 Small inducible cytokine A2 CCL2 0.069
279 Tyrosinase TYR 0.0665
62 Glycine receptor subunit beta GLRB 0.064
4054 Glycine cleavage system H protein, mitochondrial GCSH 0.0605
4823 L-allo-threonine aldolase TM_1744 0.0594
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0594
207 Glutathione synthetase GSS 0.057
5269 Glutathione synthetase gshB 0.057
6151 Monocarboxylate transporter 10 SLC16A10 0.0568
411 Glycine N-methyltransferase GNMT 0.0563
461 Glycine receptor subunit alpha-3 GLRA3 0.0563
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0557
383 Glycine amidinotransferase, mitochondrial GATM 0.0541
820 Glycine receptor subunit alpha-2 GLRA2 0.0528
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0512
593 Proton-coupled amino acid transporter 1 SLC36A1 0.051
3880 Serine hydroxymethyltransferase 1 Not Available 0.0483
1588 Multidrug resistance protein 1 ABCB1 0.0467
3883 Ornithine aminotransferase variant Not Available 0.0453
3887 Phosphorylase PYGB 0.0453
3908 P-selectin cytoplasmic tail-associated protein pcap 0.0453
3915 Cysteine sulfinic acid decarboxylase-related protein 1 CSAD 0.0453
3914 Alanine-glyoxylate aminotransferase homolog TLH6 0.0453
3911 Uncharacterized protein C20orf38 SPTLC3 0.0453
3891 Putative L-Dopa decarboxylase DDC 0.0453
306 Pyridoxal phosphate phosphatase PDXP 0.0453
3906 Serine dehydratase-like SDSL 0.0453
3881 Selenocysteine lyase variant Not Available 0.0453
3896 CDNA FLJ46802 fis, clone TRACH3032150, moderately similar to Cysteine sulfinic acid decarboxylase GADL1 0.0453
3909 Hepatic peroxysomal alanine:glyoxylate aminotransferase Not Available 0.0453
3893 DDC protein DDC 0.0453
3878 GAD1 protein GAD1 0.0453
3886 Migration-inducing protein 4 ALAS1 0.0453
3910 O-phosphoseryl-tRNA(Sec) selenium transferase SEPSECS 0.0453
3875 Glycogen phosphorylase, brain form PYGB 0.0453
855 Sphingosine-1-phosphate lyase 1 SGPL1 0.0453
3882 Brain glycogen phosphorylase variant Not Available 0.0453
3903 Aminolevulinate, delta-, synthase 2 ALAS2 0.0453
3894 KIAA0251 protein PDXDC1 0.0453
3905 Molybdenum cofactor sulfurase MOCOS 0.0453
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0453
482 Glycine receptor subunit alpha-1 GLRA1 0.0448
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0438
665 Phosphoserine aminotransferase PSAT1 0.0429
4652 Phosphoserine aminotransferase serC 0.0429
3895 Kynurenine--oxoglutarate transaminase 3 CCBL2 0.0429
420 Glutamate decarboxylase 1 GAD1 0.0429
3900 Glutamate decarboxylase 1 GAD1 0.0429
801 Kynurenine/alpha-aminoadipate aminotransferase mitochondrial AADAT 0.0429
24 Thymidylate synthase TMP1 0.0423
359 Thymidylate synthase TYMS 0.0423
2626 Thymidylate synthase thyA 0.0423
2729 Thymidylate synthase thyA 0.0423
5352 Thymidylate synthase THYA 0.0423
365 Dihydrofolate reductase DHFR 0.0397
2381 Dihydrofolate reductase DFR1 0.0397
2833 Dihydrofolate reductase Not Available 0.0397
2931 Dihydrofolate reductase folA 0.0397
3544 Dihydrofolate reductase folA 0.0397
3682 Dihydrofolate reductase folA 0.0397
6642 Dihydrofolate reductase folA 0.0397
6756 Dihydrofolate reductase dfrA 0.0397
2164 Multidrug resistance-associated protein 4 ABCC4 0.0394
3899 Alanine--glyoxylate aminotransferase 2-like 2 AGXT2L2 0.0387
3877 Growth-inhibiting protein 18 GIG18 0.0386
184 L-serine dehydratase SDS 0.0383
491 Serine palmitoyltransferase 1 SPTLC1 0.0383
431 Serine racemase SRR 0.0383
89 Cysteine sulfinic acid decarboxylase CSAD 0.0383
727 Serine palmitoyltransferase 2 SPTLC2 0.0383
534 Threonine synthase-like 1 THNSL1 0.0381
3 Histidine decarboxylase HDC 0.0379
3874 Proline synthetase co-transcribed bacterial homolog protein PROSC 0.0378
499 Arginine decarboxylase ADC 0.0374
317 Methionine-R-sulfoxide reductase SEPX1 0.0372
3996 Betaine--homocysteine S-methyltransferase 2 BHMT2 0.0372
480 Methionine-R-sulfoxide reductase B2 MSRB2 0.0372
3921 Methionine adenosyltransferase 2 subunit beta MAT2B 0.0372
3995 Methionyl-tRNA synthetase, mitochondrial MARS2 0.0372
600 Methionyl-tRNA synthetase, cytoplasmic MARS 0.0372
3913 Glutamic acid decarboxylase GAD65 0.037
426 Aspartate aminotransferase, mitochondrial GOT2 0.0369
763 Tyrosine aminotransferase TAT 0.0365
5493 Tyrosine aminotransferase Not Available 0.0365
3904 Alanine aminotransferase 2 GPT2 0.0365
735 Alanine aminotransferase 1 GPT 0.0365
435 Kynureninase KYNU 0.0357
4654 Kynureninase kynU 0.0357
1043 Trifunctional purine biosynthetic protein adenosine-3 [Includes: Phosphoribosylamine--glycine ligase GART 0.0356
169 Cysteine desulfurase, mitochondrial NFS1 0.0353
1729 Solute carrier family 22 member 6 SLC22A6 0.0351
586 Aspartate aminotransferase, cytoplasmic GOT1 0.0345
358 Cystathionine beta-synthase CBS 0.0336
5698 Riboflavin synthase alpha chain ribE 0.0336
654 Flavin reductase BLVRB 0.0332
862 Multidrug resistance-associated protein 1 ABCC1 0.0331
795 Branched-chain-amino-acid aminotransferase, mitochondrial BCAT2 0.033
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0328
472 Ornithine aminotransferase, mitochondrial OAT 0.0327
574 Branched-chain-amino-acid aminotransferase, cytosolic BCAT1 0.032
203 Pyridoxine-5'-phosphate oxidase PNPO 0.032
334 S-adenosylmethionine synthetase isoform type-2 MAT2A 0.0314
868 Cystathionine gamma-lyase CTH 0.0312
408 Riboflavin kinase RFK 0.031
301 Kynurenine--oxoglutarate transaminase 1 CCBL1 0.0305
191 Peptide methionine sulfoxide reductase MSRA 0.0303
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0303
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0297
293 Gamma-glutamyl hydrolase GGH 0.0295
941 Betaine--homocysteine S-methyltransferase 1 BHMT 0.0282
453 S-adenosylmethionine synthetase isoform type-1 MAT1A 0.0282
1650 Heme carrier protein 1 SLC46A1 0.0276
3426 Glutamine synthetase glnA 0.0268
3987 Glutamine synthetase GLUL 0.0268
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0267
244 Angiotensin-converting enzyme ACE 0.0267
4512 Cytochrome P450 3A4 CYP3A4 0.0255
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0249
4773 Deoxycytidine kinase DCK 0.0249
10 Glycogen phosphorylase, liver form PYGL 0.0243
4757 Cytochrome P450 2C9 CYP2C9 0.0238
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0238
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0237
4924 Cytochrome P450 2C8 CYP2C8 0.0233
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0227
776 Bile salt export pump ABCB11 0.0224
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0219
2361 Response regulator pleD pleD 0.0216
2516 GMP reductase 1 GMPR 0.0216
4118 Cytochrome P450 3A5 CYP3A5 0.0204
4106 Guanylate kinase GUK1 0.0202
4516 Guanylate kinase gmk 0.0202
4200 Cytochrome P450 1A2 CYP1A2 0.0201
6020 Aldehyde oxidase AOX1 0.0201
6148 Multidrug resistance-associated protein 7 ABCC10 0.0196
2795 Methionine aminopeptidase 2 METAP2 0.0192
4553 Bifunctional adenosylcobalamin biosynthesis protein cobU cobU 0.0185
1152 Glycogen phosphorylase, muscle form PYGM 0.0182
587 Serum albumin ALB 0.0181
6143 Solute carrier family 22 member 7 SLC22A7 0.0179
718 Folate receptor gamma FOLR3 0.0178
804 Mitochondrial folate transporter/carrier SLC25A32 0.0178
299 Folate receptor beta FOLR2 0.0178
338 DNA polymerase UL30 0.0173
379 DNA polymerase UL54 0.0173
697 DNA polymerase ORF28 0.0173
2482 DNA polymerase 43 0.0173
4104 DNA polymerase BALF5 0.0173
2966 PyrR bifunctional protein [Includes: Pyrimidine operon regulatory protein; Uracil phosphoribosyltransferase pyrR 0.0172
6013 Cytochrome P450 2E1 CYP2E1 0.0171
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.017
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.017
6107 Cytochrome P450 3A7 CYP3A7 0.0168
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0163
3300 Xanthine phosphoribosyltransferase xpt 0.0163
3681 Xanthine phosphoribosyltransferase gpt 0.0163
5818 Folate receptor alpha FOLR1 0.0161
686 Aldo-keto reductase family 1 member C2 AKR1C2 0.016
70 Type-1 angiotensin II receptor AGTR1 0.0158
646 Malate dehydrogenase, cytoplasmic MDH1 0.0157
635 Estradiol 17-beta-dehydrogenase 8 HSD17B8 0.0157
666 NADP-dependent malic enzyme ME1 0.0157
738 Monocarboxylate transporter 1 SLC16A1 0.0156
3941 Amine oxidase [flavin-containing] A MAOA 0.0154
2684 Histidine triad nucleotide-binding protein 1 HINT1 0.0152
11 NAD(P) transhydrogenase, mitochondrial NNT 0.0147
2339 Protein-glutamine gamma-glutamyltransferase E TGM3 0.0147
830 Glutamate dehydrogenase 2, mitochondrial GLUD2 0.0145
6142 Solute carrier family 22 member 8 SLC22A8 0.0143
3947 Xanthine dehydrogenase/oxidase XDH 0.0142
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0141
6016 Cytochrome P450 2C19 CYP2C19 0.0138
6030 Cytochrome P450 2B6 CYP2B6 0.0127
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0126
1024 Solute carrier family 22 member 11 SLC22A11 0.0125
201 Glutamate dehydrogenase 1, mitochondrial GLUD1 0.0125
83 Alpha-aminoadipic semialdehyde synthase, mitochondrial AASS 0.0125
118 Organic cation/carnitine transporter 2 SLC22A5 0.0124
448 Vitamin K-dependent gamma-carboxylase GGCX 0.0123
5718 Cytochrome P450 2A6 CYP2A6 0.0119
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0119
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0118
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0115
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0114
374 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 NDUFB1 0.0113
300 NADH-ubiquinone oxidoreductase chain 4L MT-ND4L 0.0113
343 NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial NDUFC1 0.0113
247 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 NDUFA1 0.0113
219 NADH-ubiquinone oxidoreductase chain 3 MT-ND3 0.0113
236 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 NDUFA6 0.0113
313 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 NDUFB3 0.0113
475 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial NDUFB2 0.0113
99 NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 NDUFS5 0.0113
190 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4 NDUFA4 0.0113
477 DNA topoisomerase 4 subunit A parC 0.0113
886 DNA topoisomerase 4 subunit A parC 0.0113
6226 DNA topoisomerase 4 subunit A parC 0.0113
755 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 NDUFA3 0.0113
525 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 NDUFA5 0.0113
446 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 NDUFA7 0.0113
324 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 NDUFB4 0.0113
353 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 NDUFA4L2 0.0113
602 Acyl carrier protein, mitochondrial NDUFAB1 0.0113
568 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 NDUFB7 0.0113
656 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 NDUFB9 0.0113
405 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 NDUFA8 0.0113
582 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 NDUFA13 0.0113
829 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 NDUFA12 0.0113
598 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 NDUFA11 0.0113
30 NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial NDUFV3 0.0113
607 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 NDUFA2 0.0113
272 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 NDUFB10 0.0113
270 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial NDUFB5 0.0113
417 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 NDUFB6 0.0113
104 NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial NDUFS6 0.0113
384 NADH-ubiquinone oxidoreductase chain 6 MT-ND6 0.0113
746 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial NDUFB8 0.0113
555 NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial NDUFS4 0.0113
41 NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial NDUFS8 0.0113
196 D-beta-hydroxybutyrate dehydrogenase, mitochondrial BDH1 0.0113
372 Estradiol 17-beta-dehydrogenase 3 HSD17B3 0.0113
609 15-hydroxyprostaglandin dehydrogenase [NAD+] HPGD 0.0113
141 3-hydroxyisobutyrate dehydrogenase, mitochondrial HIBADH 0.0113
644 Heme oxygenase 2 HMOX2 0.0113
4982 Heme oxygenase 2 pbsA2 0.0113
152 NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial NDUFV2 0.0113
729 GDP-L-fucose synthetase TSTA3 0.0113
3463 GDP-L-fucose synthetase fcl 0.0113
231 Glycerol-3-phosphate dehydrogenase [NAD+], cytoplasmic GPD1 0.0113
167 L-lactate dehydrogenase C chain LDHC 0.0113
14 Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial IDH3A 0.0113
91 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial NDUFA10 0.0113
206 3-keto-steroid reductase HSD17B7 0.0113
721 NADH-ubiquinone oxidoreductase chain 2 MT-ND2 0.0113
107 C-4 methylsterol oxidase SC4MOL 0.0113
616 Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial IDH3B 0.0113
335 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial NDUFA9 0.0113
326 L-lactate dehydrogenase A-like 6A LDHAL6A 0.0113
112 L-lactate dehydrogenase A-like 6B LDHAL6B 0.0113
50 Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating NSDHL 0.0113
662 Fatty aldehyde dehydrogenase ALDH3A2 0.0113
671 Pyruvate dehydrogenase E1 component alpha subunit, testis-specific form, mitochondrial PDHA2 0.0113
628 Pyruvate dehydrogenase E1 component alpha subunit, somatic form, mitochondrial PDHA1 0.0113
848 Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial IDH3G 0.0113
539 NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial NDUFV1 0.0113
145 Corticosteroid 11-beta-dehydrogenase isozyme 2 HSD11B2 0.0113
216 Aldehyde dehydrogenase 3B2 ALDH3B2 0.0113
487 Aldo-keto reductase family 1 member C4 AKR1C4 0.0113
531 Aldehyde dehydrogenase X, mitochondrial ALDH1B1 0.0113
271 Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial ALDH4A1 0.0113
608 NADH-ubiquinone oxidoreductase chain 4 MT-ND4 0.0113
496 Aldehyde dehydrogenase 3B1 ALDH3B1 0.0113
149 Alpha-aminoadipic semialdehyde dehydrogenase ALDH7A1 0.0113
637 NADH-ubiquinone oxidoreductase chain 5 MT-ND5 0.0113
34 7-dehydrocholesterol reductase DHCR7 0.0113
711 UDP-glucose 6-dehydrogenase UGDH 0.0113
3672 UDP-glucose 6-dehydrogenase hasB 0.0113
9 Estradiol 17-beta-dehydrogenase 2 HSD17B2 0.0113
180 D-3-phosphoglycerate dehydrogenase PHGDH 0.0113
3726 D-3-phosphoglycerate dehydrogenase serA 0.0113
4291 D-3-phosphoglycerate dehydrogenase serA 0.0113
258 Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial ALDH6A1 0.0113
643 Peroxisomal bifunctional enzyme EHHADH 0.0113
288 Trifunctional enzyme subunit alpha, mitochondrial HADHA 0.0113
548 NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial NDUFS1 0.0113
393 GDH/6PGL endoplasmic bifunctional protein [Includes: Glucose 1-dehydrogenase H6PD 0.0113
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0113
816 Biliverdin reductase A BLVRA 0.0113
316 4-trimethylaminobutyraldehyde dehydrogenase ALDH9A1 0.0113
579 Alcohol dehydrogenase class 4 mu/sigma chain ADH7 0.0113
792 Aldehyde dehydrogenase, dimeric NADP-preferring ALDH3A1 0.0113
6136 Multidrug resistance-associated protein 5 ABCC5 0.0112
404 DNA gyrase subunit A gyrA 0.0111
6224 DNA gyrase subunit A gyrA 0.0111
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0111
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0111
4226 Uridine phosphorylase 2 UPP2 0.011
817 DNA topoisomerase 2-alpha TOP2A 0.0109
6141 Sodium/bile acid cotransporter SLC10A1 0.0109
2443 Azurin azu 0.0108
444 Alcohol dehydrogenase 1B ADH1B 0.0108
400 Coagulation factor IX F9 0.0107
5461 Coagulation factor IX F9 0.0107
6144 Solute carrier family 22 member 2 SLC22A2 0.0102
350 3-hydroxyacyl-CoA dehydrogenase type-2 HSD17B10 0.01
4081 Vitamin K epoxide reductase complex subunit 1-like protein 1 VKORC1L1 0.01
4119 Cytochrome P450 2D6 CYP2D6 0.01
604 Vitamin K-dependent protein Z PROZ 0.01
178 NADH-cytochrome b5 reductase 3 CYB5R3 0.01
812 Dihydrolipoyl dehydrogenase, mitochondrial DLD 0.01
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0099
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0099
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0099
454 Peroxisomal multifunctional enzyme type 2 HSD17B4 0.0099
328 Sorbitol dehydrogenase SORD 0.0097
363 NADP-dependent malic enzyme, mitochondrial ME3 0.0096
396 Alcohol dehydrogenase 4 ADH4 0.0096
597 Dihydropteridine reductase QDPR 0.0096
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0096
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0095
4225 Uridine phosphorylase 1 UPP1 0.0094
857 Malate dehydrogenase, mitochondrial MDH2 0.0094
413 Amidophosphoribosyltransferase PPAT 0.0094
2515 Amidophosphoribosyltransferase purF 0.0094
3714 Amidophosphoribosyltransferase purF 0.0094
6026 Alcohol dehydrogenase 6 ADH6 0.0093
6024 Cytochrome P450 1A1 CYP1A1 0.0093
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0092
419 Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial HADH 0.0092
839 Short-chain specific acyl-CoA dehydrogenase, mitochondrial ACADS 0.0091
468 Cytochrome P450 4A11 CYP4A11 0.009
1245 Vitamin K-dependent protein S PROS1 0.009
422 Vitamin K-dependent protein C PROC 0.009
6137 Multidrug resistance-associated protein 6 ABCC6 0.0089
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0089
802 Pyrroline-5-carboxylate reductase 2 PYCR2 0.0089
248 Pyrroline-5-carboxylate reductase 1 PYCR1 0.0089
626 Cysteine dioxygenase type 1 CDO1 0.0089
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0088
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0088
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0088
12 Alcohol dehydrogenase class 3 ADH5 0.0088
77 L-lactate dehydrogenase B chain LDHB 0.0088
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0088
110 Pyruvate dehydrogenase E1 component subunit beta, mitochondrial PDHB 0.0088
822 Aldose reductase AKR1B1 0.0087
6145 Solute carrier family 22 member 1 SLC22A1 0.0087
599 Glyceraldehyde-3-phosphate dehydrogenase GAPDH 0.0087
4426 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0087
4454 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0087
4489 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0087
627 11-cis retinol dehydrogenase RDH5 0.0087
640 Aldehyde dehydrogenase 1A3 ALDH1A3 0.0087
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0087
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0085
74 Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial DLAT 0.0085
473 L-lactate dehydrogenase A chain LDHA 0.0084
794 Glyceraldehyde-3-phosphate dehydrogenase, testis-specific GAPDHS 0.0084
136 Estrogen receptor ESR1 0.0084
1435 Synaptic vesicle glycoprotein 2A SV2A 0.0084
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.0082
569 Retinal dehydrogenase 2 ALDH1A2 0.0082
850 Vasopressin V1b receptor AVPR1B 0.0081
1898 Cytochrome P450 1B1 CYP1B1 0.0078
166 NAD-dependent malic enzyme, mitochondrial ME2 0.0078
57 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I HSD3B1 0.0078
611 Retinal dehydrogenase 1 ALDH1A1 0.0077
251 Alcohol dehydrogenase 1A ADH1A 0.0074
380 Cytochrome P450 17A1 CYP17A1 0.0074
3639 Thymidine phosphorylase deoA 0.0073
3936 Thymidine phosphorylase TYMP 0.0073
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0073
3772 3-oxoacyl-[acyl-carrier-protein] reductase fabG 0.0072
5326 Oxidoreductase, short chain dehydrogenase/reductase family TM_0441 0.0072
5157 Dehydrogenase/reductase SDR family member 11 DHRS11 0.0072
5346 Oxidoreductase, aldo/keto reductase family TM_1009 0.0072
5332 MtdA bifunctional protein mtdA 0.0072
3778 NAD(P) transhydrogenase subunit beta pntB 0.0072
5322 Oxidoreductase ydhF ydhF 0.0072
4403 Protein iolS iolS 0.0072
5330 General stress protein 69 yhdN 0.0072
5333 Alcohol dehydrogenase, iron-containing TM_0920 0.0072
5342 NADH-dependent butanol dehydrogenase, putative TM_0820 0.0072
5343 NADP-dependent fatty aldehyde dehydrogenase aldH 0.0072
185 Vasopressin V1a receptor AVPR1A 0.0071
2417 Chloramphenicol acetyltransferase cat 0.0071
3278 Chloramphenicol acetyltransferase cat 0.0071
798 Osteocalcin BGLAP 0.0071
322 Vasopressin V2 receptor AVPR2 0.007
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0068
714 Glutathione reductase, mitochondrial GSR 0.0068
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0067
810 Heme oxygenase 1 HMOX1 0.0067
3391 Heme oxygenase 1 pbsA1 0.0067
4484 2,5-diketo-D-gluconic acid reductase A dkgA 0.0067
33 Cystine/glutamate transporter SLC7A11 0.0066
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0066
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0065
614 Progesterone receptor PGR 0.0064
517 Alcohol dehydrogenase 1C ADH1C 0.0063
2375 ADP-L-glycero-D-manno-heptose-6-epimerase hldD 0.0063
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0063
5073 Ferredoxin--NADP reductase petH 0.0063
5076 Ferredoxin--NADP reductase fpr 0.0063
5119 Ferredoxin--NADP reductase petH 0.0063
5121 Ferredoxin--NADP reductase fpr 0.0063
5075 Sulfite reductase [NADPH] flavoprotein alpha-component cysJ 0.0063
3270 Elongation factor G fusA 0.0062
4582 Putative pteridine reductase 2 ptr2 0.0062
369 Coagulation factor VII F7 0.0062
4628 NADP-dependent glyceraldehyde-3-phosphate dehydrogenase gapN 0.0061
2305 Isocitrate dehydrogenase [NADP] cytoplasmic IDH1 0.0061
5328 Prostaglandin F synthase Tb11.02.2310 0.0061
989 L-xylulose reductase DCXR 0.0061
1799 Glucose-6-phosphate 1-dehydrogenase G6PD 0.0061
2630 Glucose-6-phosphate 1-dehydrogenase zwf 0.0061
2286 Isocitrate dehydrogenase [NADP] icd 0.0061
2302 Isocitrate dehydrogenase [NADP] icd 0.0061
2771 Isocitrate dehydrogenase [NADP] icd 0.0061
2636 Shikimate dehydrogenase aroE 0.0061
3515 Shikimate dehydrogenase aroE 0.0061
3446 NADP-dependent alcohol dehydrogenase adh 0.0061
275 Arachidonate 5-lipoxygenase ALOX5 0.0061
2808 Chloramphenicol acetyltransferase 3 cat3 0.0061
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.006
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.006
908 Glutathione S-transferase theta-1 GSTT1 0.006
4026 Aspartyl aminopeptidase DNPEP 0.0059
4024 Mitochondrial glutamate carrier 2 SLC25A18 0.0059
4023 N-acetylglutamate synthase, mitochondrial NAGS 0.0059
4027 Glutamate receptor delta-1 subunit GRID1 0.0059
4022 Glutamate--ammonia ligase domain-containing protein 1 LGSN 0.0059
4021 Probable glutamyl-tRNA synthetase, mitochondrial EARS2 0.0059
1912 Excitatory amino acid transporter 1 SLC1A3 0.0059
927 Metabotropic glutamate receptor 8 GRM8 0.0059
4016 Excitatory amino acid transporter 5 SLC1A7 0.0059
925 Metabotropic glutamate receptor 4 GRM4 0.0059
926 Metabotropic glutamate receptor 7 GRM7 0.0059
4019 Excitatory amino acid transporter 4 SLC1A6 0.0059
1047 Excitatory amino acid transporter 2 SLC1A2 0.0059
4025 Mitochondrial glutamate carrier 1 SLC25A22 0.0059
664 Glutamate decarboxylase 2 GAD2 0.0059
3890 Glutamate decarboxylase 2 GAD2 0.0059
920 Glutamate receptor, ionotropic kainate 5 GRIK5 0.0059
915 Delta 1-pyrroline-5-carboxylate synthetase ALDH18A1 0.0059
922 Glutamate receptor 4 GRIA4 0.0059
924 Glutamate receptor, ionotropic kainate 3 GRIK3 0.0059
919 Glutamate receptor, ionotropic kainate 4 GRIK4 0.0059
4020 Glutamyl aminopeptidase ENPEP 0.0059
4018 Glutamate receptor delta-2 subunit GRID2 0.0059
4017 5-oxoprolinase OPLAH 0.0059
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0058
6297 Prostaglandin reductase 1 PTGR1 0.0056
6862 Aldo-keto reductase family 1 member B10 AKR1B10 0.0056
3062 Aspartate-semialdehyde dehydrogenase asd 0.0056
4531 Putative ketoacyl reductase actIII 0.0056
5325 2,4-dienoyl-CoA reductase, mitochondrial DECR1 0.0055
4120 NADPH--cytochrome P450 reductase POR 0.0055
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0054
2675 Pteridine reductase 1 PTR1 0.0054
3573 2,4-dienoyl-CoA reductase [NADPH] fadH 0.0054
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0053
2159 Quinone oxidoreductase CRYZ 0.0053
20 Prostaglandin G/H synthase 1 PTGS1 0.0053
1124 Sepiapterin reductase SPR 0.0053
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0051
238 Peroxisome proliferator-activated receptor gamma PPARG 0.005
625 Glutamate carboxypeptidase 2 FOLH1 0.0049
3991 Glutamine-dependent NAD(+) synthetase NADSYN1 0.0049
5 Glutaminase liver isoform, mitochondrial GLS2 0.0049
917 Glutaminase kidney isoform, mitochondrial GLS 0.0049
355 GMP synthase [glutamine-hydrolyzing] GMPS 0.0049
4353 GMP synthase [glutamine-hydrolyzing] guaA 0.0049
3984 Probable glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial PET112L 0.0049
3982 Phosphoribosylformylglycinamidine synthase PFAS 0.0049
5261 Phosphoribosylformylglycinamidine synthase purL 0.0049
668 Glutamate--cysteine ligase regulatory subunit GCLM 0.0049
5626 Nucleoside diphosphate kinase B NME2 0.0048
904 Glutathione S-transferase P GSTP1 0.0047
239 Coagulation factor X F10 0.0046
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0046
6163 Copper-transporting ATPase 2 ATP7B 0.0046
6165 Copper-transporting ATPase 1 ATP7A 0.0046
242 Asparagine synthetase [glutamine-hydrolyzing] ASNS 0.0045
916 Metabotropic glutamate receptor 1 GRM1 0.0045
6147 Solute carrier family 22 member 3 SLC22A3 0.0044
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0044
6146 High affinity copper uptake protein 1 SLC31A1 0.0044
923 Glutamate receptor 3 GRIA3 0.0044
1671 Excitatory amino acid transporter 3 SLC1A1 0.0043
186 Glutamate--cysteine ligase catalytic subunit GCLC 0.0043
76 Nitric-oxide synthase, brain NOS1 0.0043
833 Organic cation/carnitine transporter 1 SLC22A4 0.0043
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0042
896 Glutathione S-transferase Mu 1 GSTM1 0.0042
4604 Liver carboxylesterase 1 CES1 0.0042
1629 Transcription factor AP-1 JUN 0.0041
210 Bifunctional aminoacyl-tRNA synthetase [Includes: Glutamyl-tRNA synthetase EPRS 0.0041
731 HIV-1 protease HIV-1 protease 0.0041
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0039
5294 Nucleoside diphosphate kinase A NME1 0.0039
54 Prothrombin F2 0.0038
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0038
2232 Interleukin-5 IL5 0.0037
1593 Mucin-2 MUC2 0.0037
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0037
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0036
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0036
705 Glutamate receptor 1 GRIA1 0.0036
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0035
161 Tubulin beta chain TUBB 0.0034
312 Tubulin beta chain TUB2 0.0034
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0034
1757 Myeloperoxidase MPO 0.0034
290 Prostaglandin G/H synthase 2 PTGS2 0.0034
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0033
5923 Microtubule-associated protein tau MAPT 0.0033
5924 Microtubule-associated protein 4 MAP4 0.0033
921 Glutamate receptor 2 GRIA2 0.0031
1123 Eosinophil cationic protein RNASE3 0.0031
131 Synaptic vesicular amine transporter SLC18A2 0.0031
78 Acetyl-CoA acetyltransferase, mitochondrial ACAT1 0.0031
1852 Microtubule-associated protein 2 MAP2 0.0031
3811 Cytochrome P450 19A1 CYP19A1 0.003
737 Mineralocorticoid receptor NR3C2 0.003
26 Vascular endothelial growth factor receptor 3 FLT4 0.003
165 FL cytokine receptor FLT3 0.0029
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0029
273 Apoptosis regulator Bcl-2 BCL2 0.0029
32 Vascular endothelial growth factor receptor 1 FLT1 0.0028
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0028
777 Tumor necrosis factor TNF 0.0028
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0028
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0028
4192 DNA topoisomerase 2-beta TOP2B 0.0028
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0027
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0027
228 Beta platelet-derived growth factor receptor PDGFRB 0.0027
1569 G1/S-specific cyclin-D1 CCND1 0.0027
29 Tubulin beta-1 chain TUBB1 0.0026
1760 Aminopeptidase N ANPEP 0.0025
6843 Aminopeptidase N pepN 0.0025
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0025
504 Mast/stem cell growth factor receptor KIT 0.0025
117 Sterol O-acyltransferase 1 SOAT1 0.0025
6211 Tubulin epsilon chain TUBE1 0.0024
6210 Tubulin delta chain TUBD1 0.0024
6212 Tubulin gamma-1 chain TUBG1 0.0024
146 Androgen receptor AR 0.0024
407 Vascular endothelial growth factor receptor 2 KDR 0.0023
6106 Cytochrome P450 2C18 CYP2C18 0.0022
1714 Mitogen-activated protein kinase 3 MAPK3 0.0022
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0021
6149 Solute carrier family 22 member 10 SLC22A10 0.0021
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0021
558 Solute carrier family 12 member 1 SLC12A1 0.002
6085 Fatty acid-binding protein, intestinal FABP2 0.002
6167 Organic solute transporter subunit beta OSTB 0.002
6166 Organic solute transporter subunit alpha OSTA 0.002
1630 Integrin beta-2 ITGB2 0.002
489 Monocarboxylate transporter 2 SLC16A7 0.002
3587 Gastrotropin FABP6 0.002
132 ATP-binding cassette sub-family A member 1 ABCA1 0.002
2539 Tubulin alpha-1 chain TUBA4A 0.002
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.0019
6837 Serine/threonine-protein kinase 17B STK17B 0.0019
342 P protein [Includes: DNA-directed DNA polymerase P 0.0018
612 P protein [Includes: DNA-directed DNA polymerase P 0.0018
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0018
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0018
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0018
1176 Mitogen-activated protein kinase 1 MAPK1 0.0018
2449 Tubulin alpha-3 chain TUBA1A 0.0017
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0017
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0017
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.0017
6044 Serum paraoxonase/lactonase 3 PON3 0.0016
6031 Cytochrome P450 3A43 CYP3A43 0.0016
702 UMP-CMP kinase CMPK1 0.0016
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0016
6599 HTH-type transcriptional regulator ttgR ttgR 0.0015
3923 Cholinesterase BCHE 0.0015
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0015
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0015
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0015
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0015
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0015
572 Integrin alpha-L ITGAL 0.0015
2599 Tyrosine-protein kinase HCK HCK 0.0015
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0014
357 Carbonic anhydrase 2 CA2 0.0014
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0014
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0014
1353 DNA topoisomerase 1 TOP1 0.0014
3552 DNA topoisomerase 1 topA 0.0014
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0014
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0014
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0014
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0014
1313 Lactoylglutathione lyase GLO1 0.0014
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.0014
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.0014
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.0014
4122 Histone deacetylase 2 HDAC2 0.0014
7 Nitric oxide synthase, inducible NOS2 0.0013
6218 Pannexin-1 PANX1 0.0013
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0013
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0012
751 Potassium channel subfamily K member 6 KCNK6 0.0012
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.0012
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.0012
260 Cytochrome P450 51 ERG11 0.0011
761 Cytochrome P450 51 ERG11 0.0011
3163 Cytochrome P450 51 cyp51 0.0011
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0011
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0011
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0011
172 Potassium channel subfamily K member 1 KCNK1 0.0011
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0011
6220 Aryl hydrocarbon receptor AHR 0.0011
6042 Prostaglandin reductase 2 PTGR2 0.0011
340 Apoptotic protease-activating factor 1 APAF1 0.0011
84 Nuclear receptor 0B1 NR0B1 0.0011
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0011
6168 Solute carrier family 22 member 16 SLC22A16 0.0011
1192 Sulfotransferase 1A1 SULT1A1 0.0011
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0011
2391 Ferrochelatase hemH 0.0011
6502 Ferrochelatase DKFZp686P18130 0.0011
1591 Ferrochelatase, mitochondrial FECH 0.0011
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.001
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.001
469 Annexin A1 ANXA1 0.001
6043 Putative G-protein coupled receptor 44 GPR44 0.001
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.001
284 DNA-directed RNA polymerase beta chain rpoB 0.001
5773 DNA-directed RNA polymerase beta chain rpoB 0.001
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.001
825 Arsenical pump-driving ATPase ASNA1 0.001
3435 Arsenical pump-driving ATPase arsA 0.001
486 Serine/threonine-protein kinase ALS2CR7 CDK15 0.001
510 Serine/threonine-protein kinase receptor R3 ACVRL1 0.001
2105 ATP-binding cassette sub-family G member 1 ABCG1 0.001
745 Anti-Muellerian hormone type-2 receptor AMHR2 0.001
483 A-Raf proto-oncogene serine/threonine-protein kinase ARAF 0.001
733 Activin receptor type 1B ACVR1B 0.001
154 AFG3-like protein 2 AFG3L2 0.001
225 NEDD8-activating enzyme E1 regulatory subunit NAE1 0.001
21 Beta-adrenergic receptor kinase 2 ADRBK2 0.001
377 Beta-adrenergic receptor kinase 1 ADRBK1 0.001
395 ALK tyrosine kinase receptor Not Available 0.001
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.001
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.001
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.001
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0009
6495 Cytochrome c oxidase subunit 7C, mitochondrial COX7C 0.0009
6496 Cytochrome c oxidase subunit 8A, mitochondrial COX8A 0.0009
6493 Cytochrome c oxidase subunit 6C COX6C 0.0009
6499 Cytochrome c oxidase polypeptide 7A1, mitochondrial COX7A1 0.0009
6498 Cytochrome c oxidase subunit 6B1 COX6B1 0.0009
6497 Cytochrome c oxidase subunit 6A2, mitochondrial COX6A2 0.0009
6494 Cytochrome c oxidase subunit 7B, mitochondrial COX7B 0.0009
6491 Cytochrome c oxidase subunit 5A, mitochondrial COX5A 0.0009
6489 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial COX4I1 0.0009
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.0009
6559 Cytochrome c oxidase subunit 2 ctaC 0.0009
6669 Cytochrome c oxidase subunit 2 ctaC 0.0009
6490 Cytochrome c oxidase subunit 3 MT-CO3 0.0009
371 Cytochrome c oxidase subunit 1 MT-CO1 0.0009
6558 Cytochrome c oxidase subunit 1 ctaD 0.0009
292 Activin receptor type-1 ACVR1 0.0009
849 Activated CDC42 kinase 1 TNK2 0.0009
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0009
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0009
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0009
821 Acetyl-coenzyme A synthetase 2-like, mitochondrial ACSS1 0.0009
704 Long-chain-fatty-acid--CoA ligase 1 ACSL1 0.0009
386 Acetyl-coenzyme A synthetase, cytoplasmic ACSS2 0.0009
297 Adenylate cyclase type 1 ADCY1 0.0009
289 Cytosolic purine 5'-nucleotidase NT5C2 0.0008
465 Calmodulin CALM1 0.0008
2540 Choloylglycine hydrolase cbh 0.0008
484 Tyrosine-protein kinase ABL2 ABL2 0.0008
2981 Phospholipase A2, membrane associated PLA2G2A 0.0008
3810 Catechol O-methyltransferase COMT 0.0008
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.0008
6501 Fatty acid-binding protein, liver FABP1 0.0008
4043 Glutaredoxin-2, mitochondrial GLRX2 0.0007
4034 Glutaredoxin-1 GLRX 0.0007
910 Epididymal secretory glutathione peroxidase GPX5 0.0007
903 Glutathione S-transferase A5 GSTA5 0.0007
4037 Hypothetical protein GPX1 0.0007
4297 Hypothetical protein SP_1951 0.0007
4521 Hypothetical protein BC_2969 0.0007
4540 Hypothetical protein TM_1070 0.0007
4555 Hypothetical protein MT1739 0.0007
4569 Hypothetical protein mshD 0.0007
4578 Hypothetical protein PA3270 0.0007
4747 Hypothetical protein PA3967 0.0007
5177 Hypothetical protein TM_0096 0.0007
5194 Hypothetical protein PA1204 0.0007
5240 Hypothetical protein Rv2991 0.0007
5370 Hypothetical protein TM_1158 0.0007
5710 Hypothetical protein Tb927.5.1360 0.0007
1928 Leukotriene C4 synthase LTC4S 0.0007
4029 Microsomal glutathione S-transferase 3 MGST3 0.0007
4032 Microsomal glutathione S-transferase 1 MGST1 0.0007
4030 Thioredoxin domain-containing protein 12 TXNDC12 0.0007
4040 Glutathione peroxidase 7 GPX7 0.0007
907 Glutathione peroxidase 2 GPX2 0.0007
4038 Glutathione peroxidase 4 GPX4 0.0007
1975 Phospholipid hydroperoxide glutathione peroxidase, mitochondrial GPX4 0.0007
906 Glutathione peroxidase 1 GPX1 0.0007
4039 CDNA FLJ23636 fis, clone CAS07176 GPX8 0.0007
4035 Glutathione S-transferase Mu 5 GSTM5 0.0007
4036 Glutathione peroxidase 6 GPX6 0.0007
900 Glutathione S-transferase A4 GSTA4 0.0007
911 Glutathione peroxidase 3 GPX3 0.0007
4042 Glutathione transferase omega-2 GSTO2 0.0007
4033 S-formylglutathione hydrolase ESD 0.0007
1056 Gamma-glutamyltranspeptidase 1 GGT1 0.0007
740 Argininosuccinate synthase ASS1 0.0007
865 Argininosuccinate synthase ASS1 0.0007
2680 Argininosuccinate synthase argG 0.0007
3194 Argininosuccinate synthase argG 0.0007
869 Estrogen receptor beta ESR2 0.0007
952 Dipeptidyl peptidase 4 DPP4 0.0007
3809 Estrogen-related receptor gamma ESRRG 0.0007
6021 Adenosine kinase ADK 0.0007
661 ADP/ATP translocase 1 SLC25A4 0.0007
3319 Hydroxyacylglutathione hydrolase HAGH 0.0007
898 Glutathione S-transferase A3 GSTA3 0.0007
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0007
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0007
897 Glutathione S-transferase kappa 1 GSTK1 0.0007
6500 Phospholipase A2 PLA2G1B 0.0007
909 Maleylacetoacetate isomerase GSTZ1 0.0007
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0006
899 Glutathione S-transferase Mu 3 GSTM3 0.0006
905 Glutathione transferase omega-1 GSTO1 0.0006
4041 Microsomal glutathione S-transferase 2 MGST2 0.0006
291 Nitric-oxide synthase, endothelial NOS3 0.0006
871 Glucocorticoid receptor NR3C1 0.0006
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0006
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0006
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0006
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0006
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0006
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0006
2165 Glutathione S-transferase Mu 2 GSTM2 0.0006
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0006
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0006
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0006
901 Glutathione S-transferase Mu 4 GSTM4 0.0005
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0005
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0005
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0005
3932 Glutathione S-transferase A2 GSTA2 0.0005
4031 Glutathione S-transferase A1 GSTA1 0.0005
2101 Glutathione-requiring prostaglandin D synthase HPGDS 0.0005
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0005
824 Sodium-dependent serotonin transporter SLC6A4 0.0004
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