DT-Web

DB02750 - S-(Methylmercury)-L-Cysteine


Identification
Name S-(Methylmercury)-L-Cysteine
Accession Number DB02750 (EXPT00956)
Type small molecule
Description Not Available
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 335.77
Groups experimental
Monoisotopic Weight 337.006024831
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Elongation factor Tu GTP-binding domain-containing protein 1
Name Elongation factor Tu GTP-binding domain-containing protein 1
Gene Name EFTUD1
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 0.4837

Transporters


Large neutral amino acids transporter small subunit 1
Name Large neutral amino acids transporter small subunit 1
Gene Name SLC7A5
Actions Not Available
References
  • Simmons-Willis TA, Koh AS, Clarkson TW, Ballatori N: Transport of a neurotoxicant by molecular mimicry: the methylmercury-L-cysteine complex is a substrate for human L-type large neutral amino acid transporter (LAT) 1 and LAT2. Biochem J. 2002 Oct 1;367(Pt 1):239-46. - Pubmed
DTHybrid score 0.6277
Large neutral amino acids transporter small subunit 2
Name Large neutral amino acids transporter small subunit 2
Gene Name SLC7A8
Actions Not Available
References
  • Simmons-Willis TA, Koh AS, Clarkson TW, Ballatori N: Transport of a neurotoxicant by molecular mimicry: the methylmercury-L-cysteine complex is a substrate for human L-type large neutral amino acid transporter (LAT) 1 and LAT2. Biochem J. 2002 Oct 1;367(Pt 1):239-46. - Pubmed
DTHybrid score 0.4231

Predictions


Id Partner name Gene Name Score
6151 Monocarboxylate transporter 10 SLC16A10 0.167
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.0884
6559 Cytochrome c oxidase subunit 2 ctaC 0.0884
6669 Cytochrome c oxidase subunit 2 ctaC 0.0884
6557 Lactaldehyde dehydrogenase aldA 0.0883
371 Cytochrome c oxidase subunit 1 MT-CO1 0.0883
6558 Cytochrome c oxidase subunit 1 ctaD 0.0883
4990 PpcA ppcA 0.077
2283 Steroid Delta-isomerase ksi 0.071
2920 Steroid Delta-isomerase ksi 0.071
2540 Choloylglycine hydrolase cbh 0.0709
3307 Acriflavine resistance protein B acrB 0.0709
1566 Corticoliberin CRH 0.058
6147 Solute carrier family 22 member 3 SLC22A3 0.0538
301 Kynurenine--oxoglutarate transaminase 1 CCBL1 0.0524
31 Phenylalanyl-tRNA synthetase, mitochondrial FARS2 0.0485
42 Phenylalanyl-tRNA synthetase alpha chain FARSA 0.0484
6602 Phenylalanyl-tRNA synthetase alpha chain pheS 0.0484
618 Phenylalanyl-tRNA synthetase beta chain FARSB 0.0484
6603 Phenylalanyl-tRNA synthetase beta chain pheT 0.0484
758 Thyroid hormone receptor alpha THRA 0.047
346 Thyroid hormone receptor beta-1 THRB 0.0406
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0365
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0361
763 Tyrosine aminotransferase TAT 0.0336
5493 Tyrosine aminotransferase Not Available 0.0336
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0333
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0321
676 Tyrosine 3-monooxygenase TH 0.0314
532 Neutral amino acid transporter A SLC1A4 0.0277
323 Alanyl-tRNA synthetase, cytoplasmic AARS 0.0277
4070 Probable alanyl-tRNA synthetase, mitochondrial AARS2 0.0277
828 Phenylalanine-4-hydroxylase PAH 0.0273
3109 Phenylalanine-4-hydroxylase phhA 0.0273
1596 Protein-glutamine gamma-glutamyltransferase 2 TGM2 0.0271
163 D(1B) dopamine receptor DRD5 0.0263
594 Thyroxine-binding globulin SERPINA7 0.0253
432 D(4) dopamine receptor DRD4 0.0249
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0243
638 D(3) dopamine receptor DRD3 0.0242
2339 Protein-glutamine gamma-glutamyltransferase E TGM3 0.0236
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0216
2170 Transforming protein RhoA RHOA 0.0214
3197 GDP-mannose mannosyl hydrolase nudD 0.0214
5630 ADP-ribosylation factor-like protein 5A ARL5A 0.0214
5618 ADP-ribosylation factor 4 ARF4 0.0214
23 D(1A) dopamine receptor DRD1 0.0214
1882 Ras-related C3 botulinum toxin substrate 1 RAC1 0.0214
5624 GTPase rab6 0.0214
5628 Probable GTPase engC rsgA 0.0214
5627 GDP-mannose 4,6-dehydratase gca 0.0214
3366 GTP-binding protein engA der 0.0214
3899 Alanine--glyoxylate aminotransferase 2-like 2 AGXT2L2 0.0211
169 Cysteine desulfurase, mitochondrial NFS1 0.0203
563 Thyroid peroxidase TPO 0.0202
831 D(2) dopamine receptor DRD2 0.02
435 Kynureninase KYNU 0.0198
4654 Kynureninase kynU 0.0198
3396 Elongation factor Tu tufA 0.0187
5621 Elongation factor Tu tuf 0.0187
3170 Elongation factor Tu-B tufB 0.0187
3335 Probable GTP-binding protein engB engB 0.0187
3115 Ras-related protein Rab-9 RAB9A 0.0186
3270 Elongation factor G fusA 0.0186
3354 Ras-related protein Rap-2a RAP2A 0.0186
3261 Signal recognition particle protein ffh 0.0186
5619 GDP-mannose 4,6 dehydratase GMDS 0.0186
3107 Putative GTP pyrophosphokinase relA 0.0186
735 Alanine aminotransferase 1 GPT 0.0184
3904 Alanine aminotransferase 2 GPT2 0.0184
114 Alanine--glyoxylate aminotransferase 2, mitochondrial AGXT2 0.0183
6750 ADP-ribosylation factor 6 ARF6 0.0172
2521 Cell division protein ftsZ ftsZ 0.0172
3301 Cell division protein ftsZ ftsZ 0.0172
6447 Guanine nucleotide-binding protein G(t) subunit alpha-1 GNAT1 0.0172
349 Serine--pyruvate aminotransferase AGXT 0.0171
593 Proton-coupled amino acid transporter 1 SLC36A1 0.017
6790 Elongation factor 2 EEF2 0.0163
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0156
1758 GTPase HRas HRAS 0.0155
4119 Cytochrome P450 2D6 CYP2D6 0.0149
373 Transthyretin TTR 0.0148
6316 ADP-ribosylation factor 1 ARF1 0.0145
3986 Protein-glutamine gamma-glutamyltransferase 6 TGM6 0.0144
3992 Protein-glutamine gamma-glutamyltransferase Z TGM7 0.0144
3983 Protein-glutamine gamma-glutamyltransferase 5 TGM5 0.0144
3989 Glutaminyl-tRNA synthetase QARS 0.0144
1008 CTP synthase 1 CTPS 0.0144
3985 Glucosamine--fructose-6-phosphate aminotransferase [isomerizing] 2 GFPT2 0.0144
3990 Protein-glutamine gamma-glutamyltransferase 4 TGM4 0.0144
3988 Protein-glutamine gamma-glutamyltransferase K TGM1 0.0144
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.014
3978 Adenylosuccinate synthetase isozyme 1 ADSSL1 0.0138
2632 Adenylosuccinate synthetase purA 0.0135
3323 Adenylosuccinate synthetase purA 0.0135
3975 Adenylosuccinate synthetase ADSS 0.0135
4598 Adenylosuccinate synthetase Adss 0.0135
6817 Adenylosuccinate synthetase purA 0.0135
263 Neutral amino acid transporter B(0) SLC1A5 0.0123
3984 Probable glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial PET112L 0.0122
917 Glutaminase kidney isoform, mitochondrial GLS 0.0122
355 GMP synthase [glutamine-hydrolyzing] GMPS 0.0122
4353 GMP synthase [glutamine-hydrolyzing] guaA 0.0122
5 Glutaminase liver isoform, mitochondrial GLS2 0.0122
3991 Glutamine-dependent NAD(+) synthetase NADSYN1 0.0122
3982 Phosphoribosylformylglycinamidine synthase PFAS 0.0122
5261 Phosphoribosylformylglycinamidine synthase purL 0.0122
5626 Nucleoside diphosphate kinase B NME2 0.0118
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0118
5294 Nucleoside diphosphate kinase A NME1 0.0115
3971 CAD protein [Includes: Glutamine-dependent carbamoyl-phosphate synthase CAD 0.0112
314 System N amino acid transporter 1 SLC38A3 0.0112
6 Coagulation factor XIII A chain F13A1 0.0111
413 Amidophosphoribosyltransferase PPAT 0.011
2515 Amidophosphoribosyltransferase purF 0.011
3714 Amidophosphoribosyltransferase purF 0.011
199 Monocarboxylate transporter 8 SLC16A2 0.0105
587 Serum albumin ALB 0.0103
242 Asparagine synthetase [glutamine-hydrolyzing] ASNS 0.0096
1588 Multidrug resistance protein 1 ABCB1 0.0086
3426 Glutamine synthetase glnA 0.0084
3987 Glutamine synthetase GLUL 0.0084
6141 Sodium/bile acid cotransporter SLC10A1 0.0079
6142 Solute carrier family 22 member 8 SLC22A8 0.0057
4924 Cytochrome P450 2C8 CYP2C8 0.0047
4512 Cytochrome P450 3A4 CYP3A4 0.0038
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