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Guanine nucleotide-binding protein G(t) subunit alpha-1


Partner ID 6447
Name Guanine nucleotide-binding protein G(t) subunit alpha-1
Synonyms 8654
Gene name GNAT1
General function Involved in acyl binding
Specific function Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Transducin is an amplifier and one of the transducers of a visual impulse that performs the coupling between rhodopsin and cGMP-phosphodiesterase
Gene sequence + ...

ATGGGGGCTGGGGCCAGTGCTGAGGAGAAGCACTCCAGGGAGCTGGAAAAGAAGCTGAAAGAGGACGCTGAGAAGGATGCTCGAACCGTGAAGCTGCTGCTTCTGGGTGCCGGTGAGTCCGGGAAGAGCACCATCGTCAAGCAGATGAAGATTATCCACCAGGACGGGTACTCGCTGGAAGAGTGCCTCGAGTTTATCGCCATCATCTACGGCAACACGTTGCAGTCCATCCTGGCCATCGTACGCGCCATGACCACACTCAACATCCAGTACGGAGACTCTGCACGCCAGGACGACGCCCGGAAGCTGATGCACATGGCAGACACTATCGAGGAGGGCACGATGCCCAAGGAGATGTCGGACATCATCCAGCGGCTGTGGAAGGACTCCGGTATCCAGGCCTGTTTTGAGCGCGCCTCGGAGTACCAGCTCAACGACTCGGCGGGCTACTACCTCTCCGACCTGGAGCGCCTGGTAACCCCGGGCTACGTGCCCACCGAGCAGGACGTGCTGCGCTCGCGAGTCAAGACCACTGGCATCATCGAGACGCAGTTCTCCTTCAAGGATCTCAACTTCCGGATGTTCGATGTGGGCGGGCAGCGCTCGGAGCCGAAGAAGTGGATCCACTGCTTCGAGGGCGTGACCTGCATCATCTTCATCGCGGCGCTGACCGCGTACGACATGGTGCTAGTGGAGGACGACGAAGTGAACCGCATGCACGAGAGCCTGCACCTGTTCAACAGCATCTGCAACCACCGCTACTTCGCCACGACGTCCATCGTGCTCTTCCTTAACAAGAAGGACGTCTTCTTCGAGAAGGTCAAGAAGGCGCACCTCAGCATCTGTTTCCCGGACTACGATGGACCCAACACCTACGAGGACGCCGGCAACTACATCAAGGTGCAGTTCCTCGAGCTCAACATGCGGCGCGACGTGAAGGAGATCTATTCCCACATGACGTGCGCCACCGACACGCAGAACGTCAAATTCTGCTTCGACGCTGTCACCGACATCATCATCAAGGAGAACCTCAAAGACTGTGGCCTCTTCTGA
Protein sequence + ...

MGAGASAEEKHSRELEKKLKEDAEKDARTVKLLLLGAGESGKSTIVKQMKIIHQDGYSLEECLEFIAIIYGNTLQSILAIVRAMTTLNIQYGDSARQDDARKLMHMADTIEEGTMPKEMSDIIQRLWKDSGIQACFERASEYQLNDSAGYYLSDLERLVTPGYVPTEQDVLRSRVKTTGIIETQFSFKDLNFRMFDVGGQRSERKKWIHCFEGVTCIIFIAALSAYDMVLVEDDEVNRMHESLHLFNSICNHRYFATTSIVLFLNKKDVFFEKIKKAHLSICFPDYDGPNTYEDAGNYIKVQFLELNMRRDVKEIYSHMTCATDTQNVKFVFDAVTDIIIKENLKDCGLF
GO Classification
function
guanyl nucleotide binding
GTP binding
binding
nucleotide binding
purine nucleotide binding
signal transducer activity
process
cellular process
cell communication
signal transduction
cell surface receptor linked signal transduction
G-protein coupled receptor protein signaling pathway
See more information at   →   www.drugbank.ca

Drugs


Associated as Target

Id Name
DB02994 Hydroxydimethylarsine Oxide
DB04315 Guanosine-5'-Diphosphate
DB04444 Tetrafluoroaluminate Ion

Associated as Prediction

Id Name
DB00125 L-Arginine
DB00128 L-Aspartic Acid
DB00130 L-Glutamine
DB00155 L-Citrulline
DB00157 NADH
DB00300 Tenofovir
DB00360 Tetrahydrobiopterin
DB00441 Gemcitabine
DB00605 Sulindac
DB00709 Lamivudine
DB00718 Adefovir Dipivoxil
DB00997 Doxorubicin
DB01110 Miconazole
DB01660 Adenosine-5'-Diphosphate Monothiophosphate
DB01686 N,N-dimethylarginine
DB01689 Inhibitor Idd 384
DB01821 L-N(Omega)-Nitroarginine-2,4-L-Diaminobutyric Amide
DB01833 L-2-Amino-4-(Guanidinooxy)Butyric Acid
DB01864 5'-Guanosine-Diphosphate-Monothiophosphate
DB01936 Ribose
DB01942 Formic Acid
DB01944 (S)-blebbistatin
DB01972 Guanosine-5'-Monophosphate
DB01997 3-Bromo-7-Nitroindazole
DB02007 Alpha-D-Glucose-6-Phosphate
DB02020 Alrestatin
DB02021 Fidarestat
DB02027 N-{(4s)-4-Amino-5-[(2-Aminoethyl)Amino]Pentyl}-N'-Nitroguanidine
DB02044 N-(3-(Aminomethyl)Benzyl)Acetamidine
DB02048 1,2,4-Triazole-Carboxamidine
DB02059 Adenosine-5-Diphosphoribose
DB02077 L-N(Omega)-Nitroarginine-(4r)-Amino-L-Proline Amide
DB02086 (3,4-Dihydroxy-Phenyl)-Triphenyl-Arsonium
DB02101 Fidarestat(Stereoisomer)
DB02109 Hadacidin
DB02132 [3-(4-Bromo-2-Fluoro-Benzyl)-7-Chloro-2,4-Dioxo-3,4-Dihydro-2h-Quinazolin-1-Yl]-Acetic Acid
DB02141 S,S'-(1,4-Phenylene-Bis(1,2-Ethanediyl))Bis-Isothiourea
DB02181 2'-Deoxyguanosine-5'-Triphosphate
DB02207 7-Nitroindazole
DB02210 Hexane-1,6-Diol
DB02212 Pyrophosphate 2-
DB02234 Ethylisothiourea
DB02335 2-Aminothiazoline
DB02345 Selenocysteine
DB02383 Tolrestat
DB02493 Hydantocidin-5'-Phosphate
DB02518 N-Acetylalanine
DB02547 Guanosine-5'-Diphosphate-Rhamnose
DB02569 2',3'-Dehydro-2',3'-Deoxy-Thymidine 5'-Diphosphate
DB02589 Se-Ethyl-Isoselenourea
DB02607 Adenosine Phosphonoacetic Acid
DB02666 (C8-R)-Hydantocidin 5'-Phosphate
DB02682 2-Deamino-6-Deoxy-6thiophosphite-5'-Phosphate Guanosine
DB02692 (6r,1'r,2's)-5,6,7,8 Tetrahydrobiopterin
DB02703 Fusidic Acid
DB02712 Sorbinil
DB02750 S-(Methylmercury)-L-Cysteine
DB02774 1,3-Propandiol
DB02834 IDD552
DB02836 Guanosine 5'-Diphosphate 2':3'-Cyclic Monophosphate
DB02887 2',3'-Dehydro-2',3'-Deoxy-Thymidine 5'-Triphosphate
DB02911 2,4-Diamino-6-Phenyl-5,6,7,8,-Tetrahydropteridine
DB02954 (Carboxyhydroxyamino)Ethanoic Acid
DB02975 Ge2270a
DB02979 N1,N14-Bis((S-Methyl)Isothioureido)Tetradecane
DB02994 Hydroxydimethylarsine Oxide
DB03014 Heme
DB03065 7-Nitroindazole-2-Carboxamidine
DB03100 6-Nitroindazole
DB03103 Thymidine-5'- Diphosphate
DB03118 1-(5-Chloroindol-3-Yl)-3-Hydroxy-3-(2h-Tetrazol-5-Yl)-Propenone
DB03126 Mant-Adp
DB03144 N-Omega-Hydroxy-L-Arginine
DB03146 2-Deazo-6-Thiophosphate Guanosine-5'-Monophosphate
DB03152 B-2-Octylglucoside
DB03222 2'-Deoxyadenosine 5'-Triphosphate
DB03223 Diphthamide
DB03226 Trifluoroethanol
DB03305 N5-Iminoethyl-L-Ornithine
DB03332 5,6-Cyclic-Tetrahydropteridine
DB03403 Cytidine-5'-Monophosphate
DB03431 Adenosine-5'-Diphosphate
DB03435 Uridine-5'-Diphosphate
DB03461 2'-Monophosphoadenosine 5'-Diphosphoribose
DB03491 2'-Deoxyguanosine-5'-Diphosphate
DB03510 6-O-Phosphoryl Inosine Monophosphate
DB03664 P1-(Adenosine-5'-P5-(Uridine-5')Pentaphosphate
DB03676 Cystein-S-Yl Cacodylate
DB03707 S-Ethyl-N-Phenyl-Isothiourea
DB03793 Benzoic Acid
DB03909 Adenosine-5'-[Beta, Gamma-Methylene]Triphosphate
DB03910 S,S'-(1,3-Phenylene-Bis(1,2-Ethanediyl))Bis-Isothiourea
DB03918 6s-5,6,7,8-Tetrahydrobiopterin
DB03963 S-(Dimethylarsenic)Cysteine
DB03974 L-Homoarginine
DB04018 S-Isopropyl-Isothiourea
DB04068 Fudp
DB04075 N-Acetyl-L-Glutamate
DB04077 Glycerol
DB04121 Guanosine-3'-Monophosphate-5'-Diphosphate
DB04124 Aurodox
DB04137 Guanosine-5'-Triphosphate
DB04223 Nitroarginine
DB04272 Citric Acid
DB04315 Guanosine-5'-Diphosphate
DB04366 3'-Deoxy 3'-Amino Adenosine-5'-Diphosphate
DB04395 Phosphoaminophosphonic Acid-Adenylate Ester
DB04418 Adenylosuccinic Acid
DB04435 Tetraphenyl-Arsonium
DB04444 Tetrafluoroaluminate Ion
DB04460 (C8-S)-Hydantocidin 5'-Phosphate
DB04534 5-Nitroindazole
DB04542 3'-Azido-3'-Deoxythymidine-5'-Diphosphate
DB04559 N-(Chlorophenyl)-N'-Hydroxyguanidine
DB04566 Inosinic Acid
DB04638 2,5-DI-(TERT-BUTYL)-1,4,BENZOHYDROQUINONE
DB07001 (3S,5E)-3-propyl-3,4-dihydrothieno[2,3-f][1,4]oxazepin-5(2H)-imine
DB07028 (2-{[(4-BROMO-2-FLUOROBENZYL)AMINO]CARBONYL}-5-CHLOROPHENOXY)ACETIC ACID
DB07030 (5-CHLORO-2-{[(3-NITROBENZYL)AMINO]CARBONYL}PHENOXY)ACETIC ACID
DB07063 {3-[(4,5,7-TRIFLUORO-1,3-BENZOTHIAZOL-2-YL)METHYL]-1H-INDOL-1-YL}ACETIC ACID
DB07093 {3-[(5-CHLORO-1,3-BENZOTHIAZOL-2-YL)METHYL]-2,4-DIOXO-3,4-DIHYDROPYRIMIDIN-1(2H)-YL}ACETIC ACID
DB07139 3-[5-(3-nitrophenyl)thiophen-2-yl]propanoic acid
DB07187 6-[(5-CHLORO-3-METHYL-1-BENZOFURAN-2-YL)SULFONYL]PYRIDAZIN-3(2H)-ONE
DB07244 5-{4-[(3,5-DIFLUOROBENZYL)AMINO]PHENYL}-6-ETHYLPYRIMIDINE-2,4-DIAMINE
DB07348 1,6,7,8,9,11A,12,13,14,14A-DECAHYDRO-1,13-DIHYDROXY-6-METHYL-4H-CYCLOPENT[F]OXACYCLOTRIDECIN-4-ONE
DB07388 ETHYL 4-[(4-METHYLPYRIDIN-2-YL)AMINO]PIPERIDINE-1-CARBOXYLATE
DB07450 2[4-BROMO-2-FLUOROPHENYL)METHYL]-6-FLUOROSPIRO[ISOQUINOLINE-4-(1H),3'-PYRROLIDINE]-1,2',3,5'(2H)-TETRONE
DB07468 (3aS)-3a-hydroxy-5-methyl-1-phenyl-1,2,3,3a-tetrahydro-4H-pyrrolo[2,3-b]quinolin-4-one
DB07469 (3aS)-3a-hydroxy-7-methyl-1-phenyl-1,2,3,3a-tetrahydro-4H-pyrrolo[2,3-b]quinolin-4-one
DB07470 (3aS)-3a-hydroxy-1-phenyl-1,2,3,3a-tetrahydro-4H-pyrrolo[2,3-b]quinolin-4-one
DB07498 4-[3-(3-NITROPHENYL)-1,2,4-OXADIAZOL-5-YL]BUTANOIC ACID
DB07575 2,4-DIAMINO-1,5-DIPHENYL-3-HYDROXYPENTANE
DB07604 (6AR,11AS,11BR)-10-ACETYL-9-HYDROXY-7,7-DIMETHYL-2,6,6A,7,11A,11B-HEXAHYDRO-11H-PYRROLO[1',2':2,3]ISOINDOLO[4,5,6-CD]INDOL-11-ONE
DB07690 (3ALPHA,5BETA,12ALPHA)-3,12-DIHYDROXYCHOLAN-24-OIC ACID
DB07999 {4-[(CARBOXYMETHOXY)CARBONYL]-3,3-DIOXIDO-1-OXONAPHTHO[1,2-D]ISOTHIAZOL-2(1H)-YL}ACETIC ACID
DB08000 2-(CARBOXYMETHYL)-1-OXO-1,2-DIHYDRONAPHTHO[1,2-D]ISOTHIAZOLE-4-CARBOXYLIC ACID 3,3-DIOXIDE
DB08018 N-{(3S,4S)-4-[(6-AMINO-4-METHYLPYRIDIN-2-YL)METHYL]PYRROLIDIN-3-YL}-N'-(4-CHLOROBENZYL)ETHANE-1,2-DIAMINE
DB08019 N-{(3R,4S)-4-[(6-amino-4-methylpyridin-2-yl)methyl]pyrrolidin-3-yl}-N'-(3-chlorobenzyl)ethane-1,2-diamine
DB08027 1-(3-chloro-4-methylphenyl)-3-{2-[({5-[(dimethylamino)methyl]-2-furyl}methyl)thio]ethyl}urea
DB08084 IDD594
DB08098 {[5-(5-NITRO-2-FURYL)-1,3,4-OXADIAZOL-2-YL]THIO}ACETIC ACID
DB08185 2-METHYLTHIO-N6-ISOPENTENYL-ADENOSINE-5'-MONOPHOSPHATE
DB08231 MYRISTIC ACID
DB08276 N-METHYL O-NITROPHENYL AMINOETHYLDIPHOSPHATE BERYLLIUM TRIFLUORIDE
DB08348 N~2~,N~2~-DIMETHYL-N~1~-(6-OXO-5,6-DIHYDROPHENANTHRIDIN-2-YL)GLYCINAMIDE
DB08449 2-(3-((4,5,7-trifluorobenzo[d]thiazol-2-yl)methyl)-1H-pyrrolo[2,3-b]pyridin-1-yl)acetic acid
DB08751 N,N'-DIMETHYL-N-(ACETYL)-N'-(7-NITROBENZ-2-OXA-1,3-DIAZOL-4-YL)ETHYLENEDIAMINE
DB08772 3,4-DIHYDRO-4-OXO-3-((5-TRIFLUOROMETHYL-2-BENZOTHIAZOLYL)METHYL)-1-PHTHALAZINE ACETIC ACID
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