DT-Web

DB01864 - 5'-Guanosine-Diphosphate-Monothiophosphate


Identification
Name 5'-Guanosine-Diphosphate-Monothiophosphate
Accession Number DB01864 (EXPT01651)
Type small molecule
Description Guanosine 5'-(trihydrogen diphosphate), monoanhydride with phosphorothioic acid. A stable GTP analog which enjoys a variety of physiological actions such as stimulation of guanine nucleotide-binding proteins, phosphoinositide hydrolysis, cyclic AMP accumulation, and activation of specific proto-oncogenes. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 539.246
Groups experimental
Monoisotopic Weight 538.967815849
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


ADP-ribosylation factor 6
Name ADP-ribosylation factor 6
Gene Name ARF6
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 0.5902
Protein-glutamine gamma-glutamyltransferase E
Name Protein-glutamine gamma-glutamyltransferase E
Gene Name TGM3
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.5545
Cell division protein ftsZ
Name Cell division protein ftsZ
Gene Name ftsZ
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.586
Ras-related protein Rab-11A
Name Ras-related protein Rab-11A
Gene Name RAB11A
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score Not Available

Predictions


Id Partner name Gene Name Score
3301 Cell division protein ftsZ ftsZ 0.586
5618 ADP-ribosylation factor 4 ARF4 0.0568
5630 ADP-ribosylation factor-like protein 5A ARL5A 0.0561
3197 GDP-mannose mannosyl hydrolase nudD 0.056
5624 GTPase rab6 0.056
1882 Ras-related C3 botulinum toxin substrate 1 RAC1 0.056
2170 Transforming protein RhoA RHOA 0.056
5628 Probable GTPase engC rsgA 0.0559
3366 GTP-binding protein engA der 0.0559
5627 GDP-mannose 4,6-dehydratase gca 0.0559
1596 Protein-glutamine gamma-glutamyltransferase 2 TGM2 0.0527
6316 ADP-ribosylation factor 1 ARF1 0.0498
3261 Signal recognition particle protein ffh 0.0488
3115 Ras-related protein Rab-9 RAB9A 0.0488
3335 Probable GTP-binding protein engB engB 0.0487
3354 Ras-related protein Rap-2a RAP2A 0.0487
3170 Elongation factor Tu-B tufB 0.0487
3396 Elongation factor Tu tufA 0.0487
5621 Elongation factor Tu tuf 0.0487
3270 Elongation factor G fusA 0.0487
5619 GDP-mannose 4,6 dehydratase GMDS 0.0487
3107 Putative GTP pyrophosphokinase relA 0.0487
3067 Aquaporin Z aqpZ 0.0482
6320 Aquaporin Z aqpZ 0.0482
6556 Elongation factor Tu GTP-binding domain-containing protein 1 EFTUD1 0.045
6447 Guanine nucleotide-binding protein G(t) subunit alpha-1 GNAT1 0.0449
6790 Elongation factor 2 EEF2 0.0424
6385 H subunit of photosynthetic reaction center complex puhA 0.042
6388 Cytochrome c1 petC 0.0419
6387 Ubiquinol-cytochrome c reductase iron-sulfur subunit petA 0.0419
1227 Cytochrome b MT-CYB 0.0419
6386 Cytochrome b petB 0.0419
6937 Cytochrome b MT-CYB 0.0419
3023 DNA polymerase I, thermostable polA 0.0418
1758 GTPase HRas HRAS 0.0406
3978 Adenylosuccinate synthetase isozyme 1 ADSSL1 0.036
2632 Adenylosuccinate synthetase purA 0.0354
3323 Adenylosuccinate synthetase purA 0.0354
3975 Adenylosuccinate synthetase ADSS 0.0354
4598 Adenylosuccinate synthetase Adss 0.0354
6817 Adenylosuccinate synthetase purA 0.0354
2516 GMP reductase 1 GMPR 0.0332
2361 Response regulator pleD pleD 0.0332
5626 Nucleoside diphosphate kinase B NME2 0.0324
5294 Nucleoside diphosphate kinase A NME1 0.0303
4106 Guanylate kinase GUK1 0.0302
4516 Guanylate kinase gmk 0.0302
4553 Bifunctional adenosylcobalamin biosynthesis protein cobU cobU 0.0289
2207 Rhodopsin RHO 0.0275
2966 PyrR bifunctional protein [Includes: Pyrimidine operon regulatory protein; Uracil phosphoribosyltransferase pyrR 0.0266
338 DNA polymerase UL30 0.0266
379 DNA polymerase UL54 0.0266
697 DNA polymerase ORF28 0.0266
2482 DNA polymerase 43 0.0266
4104 DNA polymerase BALF5 0.0266
3300 Xanthine phosphoribosyltransferase xpt 0.0251
3681 Xanthine phosphoribosyltransferase gpt 0.0251
2684 Histidine triad nucleotide-binding protein 1 HINT1 0.0234
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0225
4373 Medium-chain-fatty-acid--CoA ligase Not Available 0.0212
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0194
6742 Recoverin RCVRN 0.0154
6752 Guanylyl cyclase-activating protein 1 GUCA1A 0.0154
6743 Non-fluorescent flavoprotein luxF 0.0154
394 Calcineurin subunit B isoform 1 PPP3R1 0.0154
6753 Apolipoprotein M APOM 0.0154
6747 Chalcone/stilbene synthase family protein MT1417 0.0154
6741 Peroxisomal 3,2-trans-enoyl-CoA isomerase PECI 0.0154
2528 Fatty acid metabolism regulator protein fadR 0.0154
6740 Fatty acid metabolism regulator protein fadR 0.0154
6522 Hepatocyte nuclear factor 4-alpha HNF4A 0.0154
6751 Gag polyprotein gag 0.0154
6746 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform PPP3CA 0.0154
6749 Polyprotein Not Available 0.0154
6527 Lymphocyte antigen 96 LY96 0.0134
5961 Insulin INS 0.0134
6755 Poliovirus receptor PVR 0.0134
3986 Protein-glutamine gamma-glutamyltransferase 6 TGM6 0.0124
6 Coagulation factor XIII A chain F13A1 0.0124
5432 Trafficking protein particle complex subunit 3 TRAPPC3 0.0124
6524 Protein tonB tonB 0.0124
3983 Protein-glutamine gamma-glutamyltransferase 5 TGM5 0.0123
3992 Protein-glutamine gamma-glutamyltransferase Z TGM7 0.0123
3990 Protein-glutamine gamma-glutamyltransferase 4 TGM4 0.0123
3988 Protein-glutamine gamma-glutamyltransferase K TGM1 0.0123
1008 CTP synthase 1 CTPS 0.0122
3985 Glucosamine--fructose-6-phosphate aminotransferase [isomerizing] 2 GFPT2 0.0122
3989 Glutaminyl-tRNA synthetase QARS 0.0122
2616 Ganglioside GM2 activator GM2A 0.0117
2435 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase lpxC 0.0111
6613 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase lpxC 0.0111
5598 Glycerol uptake operon antiterminator-related protein TM_1436 0.0111
4238 50S ribosomal protein L4 rplD 0.0111
5578 50S ribosomal protein L4 rplD 0.0111
6173 50S ribosomal protein L4 rplD 0.0111
6219 50S ribosomal protein L4 rplD 0.0111
2838 Ribose-5-phosphate isomerase A rpiA 0.0111
2952 Ribose-5-phosphate isomerase A rpiA 0.0111
5595 Ribose-5-phosphate isomerase A rpiA 0.0111
5590 N utilization substance protein B homolog nusB 0.0111
5577 N5-carboxyaminoimidazole ribonucleotide mutase purE 0.0111
5591 Complement component C8 gamma chain C8G 0.0111
3792 KHG/KDPG aldolase [Includes: 4-hydroxy-2-oxoglutarate aldolase eda 0.0111
5582 Regulator of transcription; stringent starvation protein A sspA 0.0111
5583 RNA 3'-terminal phosphate cyclase rtcA 0.0111
5060 Intron-associated endonuclease 1 ITEVIR 0.0111
5593 Transferase Not Available 0.0111
5588 Cell division protein FtsY TM_0570 0.0111
4695 UPF0124 protein yfiH yfiH 0.0111
5592 Ribonucleoside-diphosphate reductase subunit beta nrdF 0.0111
2300 Lysozyme E 0.0111
3633 Lysozyme R 0.0111
5597 Lysozyme 17 0.0111
5587 Iron(III)-binding periplasmic protein fbpA 0.0111
5586 Pleckstrin homology domain-containing family A member 1 PLEKHA1 0.011
4375 Glutamine synthetase 1 glnA1 0.011
5575 Short tail fiber protein 12 0.011
5600 Pyruvate decarboxylase pdc 0.011
5580 Hexon protein PII 0.011
5574 Invasin YPTB1668 0.011
5581 Beta-fructosidase bfrA 0.011
3971 CAD protein [Includes: Glutamine-dependent carbamoyl-phosphate synthase CAD 0.0108
4210 Toll-like receptor 4 TLR4 0.0107
301 Kynurenine--oxoglutarate transaminase 1 CCBL1 0.0106
2297 Genome polyprotein Not Available 0.0104
2322 Genome polyprotein Not Available 0.0104
2694 Genome polyprotein Not Available 0.0104
2719 Genome polyprotein Not Available 0.0104
2860 Genome polyprotein Not Available 0.0104
2928 Genome polyprotein Not Available 0.0104
3160 Genome polyprotein Not Available 0.0104
3260 Genome polyprotein Not Available 0.0104
4783 Genome polyprotein Not Available 0.0104
5726 Genome polyprotein Not Available 0.0104
5779 Genome polyprotein Not Available 0.0104
5867 Genome polyprotein Not Available 0.0104
6253 Genome polyprotein Not Available 0.0104
6301 Genome polyprotein Not Available 0.0104
6380 Genome polyprotein Not Available 0.0104
6381 Genome polyprotein Not Available 0.0104
6437 Genome polyprotein Not Available 0.0104
6520 Genome polyprotein Not Available 0.0104
6521 Genome polyprotein Not Available 0.0104
6652 Genome polyprotein Not Available 0.0104
6734 Genome polyprotein Not Available 0.0104
6735 Genome polyprotein Not Available 0.0104
6736 Genome polyprotein Not Available 0.0104
6737 Genome polyprotein Not Available 0.0104
6738 Genome polyprotein Not Available 0.0104
6739 Genome polyprotein Not Available 0.0104
6744 Genome polyprotein Not Available 0.0104
6748 Genome polyprotein Not Available 0.0104
6894 Genome polyprotein Not Available 0.0104
6898 Genome polyprotein Not Available 0.0104
413 Amidophosphoribosyltransferase PPAT 0.0104
2515 Amidophosphoribosyltransferase purF 0.0104
3714 Amidophosphoribosyltransferase purF 0.0104
3982 Phosphoribosylformylglycinamidine synthase PFAS 0.0103
5261 Phosphoribosylformylglycinamidine synthase purL 0.0103
5 Glutaminase liver isoform, mitochondrial GLS2 0.0103
917 Glutaminase kidney isoform, mitochondrial GLS 0.0103
355 GMP synthase [glutamine-hydrolyzing] GMPS 0.0103
4353 GMP synthase [glutamine-hydrolyzing] guaA 0.0103
3991 Glutamine-dependent NAD(+) synthetase NADSYN1 0.0103
3984 Probable glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial PET112L 0.0103
263 Neutral amino acid transporter B(0) SLC1A5 0.0102
864 Gag-Pol polyprotein gag-pol 0.0099
2237 Gag-Pol polyprotein gag-pol 0.0099
2326 Gag-Pol polyprotein gag-pol 0.0099
2451 Gag-Pol polyprotein gag-pol 0.0099
2901 Gag-Pol polyprotein gag-pol 0.0099
3165 Gag-Pol polyprotein gag-pol 0.0099
3722 Gag-Pol polyprotein gag-pol 0.0099
6306 Gag-Pol polyprotein gag-pol 0.0099
6624 Gag-Pol polyprotein gag-pol 0.0099
3132 Tryptophan synthase alpha chain trpA 0.0096
6568 Tryptophan synthase alpha chain trpA 0.0096
5328 Prostaglandin F synthase Tb11.02.2310 0.0096
3085 Molybdopterin-guanine dinucleotide biosynthesis protein A mobA 0.0096
5006 RNASE4 protein RNASE4 0.0096
4533 Glyoxalase family protein BC_1747 0.0096
5599 3-carboxy-cis,cis-muconate cycloisomerase pcaB 0.0096
4992 Cytochrome c peroxidase Not Available 0.0096
3729 Citrate synthase gltA 0.0096
4575 Citrate synthase cit 0.0096
4580 Citrate synthase gltA 0.0096
3087 Nicotinate-nucleotide adenylyltransferase nadD 0.0096
4469 Nicotinate-nucleotide adenylyltransferase nadD 0.0096
2555 Pol polyprotein pol 0.0096
3242 Pol polyprotein gag-pol 0.0096
3471 Pol polyprotein gag-pro-pol 0.0096
5256 Pol polyprotein pol 0.0096
6469 Pol polyprotein gag-pol 0.0096
6565 Pol polyprotein Not Available 0.0096
314 System N amino acid transporter 1 SLC38A3 0.0094
866 Large neutral amino acids transporter small subunit 2 SLC7A8 0.0092
3583 6-phosphogluconolactonase pgl 0.0089
2149 Angiogenin ANG 0.0089
1467 Tumor necrosis factor ligand superfamily member 13B TNFSF13B 0.0089
2603 Beta-lactamase II blm 0.0089
242 Asparagine synthetase [glutamine-hydrolyzing] ASNS 0.0088
6085 Fatty acid-binding protein, intestinal FABP2 0.0086
2427 Ferrichrome-iron receptor fhuA 0.0086
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0084
3486 Fumarate hydratase class II fumC 0.0084
4366 Riboflavin kinase/FMN adenylyltransferase TM_0857 0.0084
2286 Isocitrate dehydrogenase [NADP] icd 0.0084
2302 Isocitrate dehydrogenase [NADP] icd 0.0084
2771 Isocitrate dehydrogenase [NADP] icd 0.0084
2869 1-deoxy-D-xylulose 5-phosphate reductoisomerase dxr 0.0084
2942 Sialidase nanH 0.0084
3546 Sialidase nedA 0.0084
857 Malate dehydrogenase, mitochondrial MDH2 0.0083
768 FK506-binding protein 1A FKBP1A 0.0083
6228 Nuclear receptor coactivator 1 NCOA1 0.0082
3426 Glutamine synthetase glnA 0.0082
3987 Glutamine synthetase GLUL 0.0082
2805 Heparan sulfate glucosamine 3-O-sulfotransferase 3A1 HS3ST3A1 0.008
6264 cAMP-dependent protein kinase inhibitor alpha PKIA 0.0078
941 Betaine--homocysteine S-methyltransferase 1 BHMT 0.0078
2697 Uridine-cytidine kinase 2 UCK2 0.0077
2936 Oxygen-insensitive NAD(P)H nitroreductase nfnB 0.0077
5184 Oxygen-insensitive NAD(P)H nitroreductase nfnB 0.0077
1123 Eosinophil cationic protein RNASE3 0.0077
332 Beta-lactamase blaZ 0.0077
2478 Beta-lactamase ampC 0.0077
2613 Beta-lactamase ampC 0.0077
2635 Beta-lactamase ampC 0.0077
2700 Beta-lactamase penP 0.0077
5445 Beta-lactamase blaB 0.0077
6019 Beta-lactamase SHV-7 0.0077
6701 Beta-lactamase cphA 0.0077
2452 Tryptophanyl-tRNA synthetase trpS 0.0076
5579 Carboxypeptidase B CPB1 0.0073
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.0072
3478 Glucose-1-phosphate thymidylyltransferase rmlA 0.0072
4277 Glucose-1-phosphate thymidylyltransferase rmlA 0.0072
3384 Macrophage migration inhibitory factor MIF 0.0071
411 Glycine N-methyltransferase GNMT 0.007
128 Adenine phosphoribosyltransferase APRT 0.0065
6151 Monocarboxylate transporter 10 SLC16A10 0.0064
465 Calmodulin CALM1 0.0062
5682 Ribonuclease pancreatic RNASE1 0.0055
822 Aldose reductase AKR1B1 0.0055
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0051
587 Serum albumin ALB 0.0041
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0041
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