DT-Web

DB03222 - 2'-Deoxyadenosine 5'-Triphosphate


Identification
Name 2'-Deoxyadenosine 5'-Triphosphate
Accession Number DB03222 (EXPT01288)
Type small molecule
Description Not Available
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 491.1816
Groups experimental
Monoisotopic Weight 491.000830537
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


DNA primase/helicase
Name DNA primase/helicase
Gene Name 4
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.8571
DNA polymerase beta
Name DNA polymerase beta
Gene Name POLB
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 1.1803
Ribonucleoside-diphosphate reductase 2 alpha subunit
Name Ribonucleoside-diphosphate reductase 2 alpha subunit
Gene Name nrdE
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 1.0589
Anaerobic ribonucleoside-triphosphate reductase
Name Anaerobic ribonucleoside-triphosphate reductase
Gene Name NRDD
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 1.2397
Protein recA
Name Protein recA
Gene Name recA
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.8674
Protein recA
Name Protein recA
Gene Name recA
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.8674

Predictions


Id Partner name Gene Name Score
2315 Protein recA recA 0.8674
5263 Protein recA recA 0.8674
2712 Deoxycytidine triphosphate deaminase dcd 0.2762
3023 DNA polymerase I, thermostable polA 0.276
3481 Glucose-1-phosphate thymidylyltransferase 2 rmlA2 0.2496
3478 Glucose-1-phosphate thymidylyltransferase rmlA 0.2173
4277 Glucose-1-phosphate thymidylyltransferase rmlA 0.2173
2290 ADP-ribosyl cyclase 2 BST1 0.2138
2320 Thymidine kinase, cytosolic TK1 0.1661
2251 Thymidylate kinase tmk 0.165
2254 Thymidylate kinase DTYMK 0.165
3522 Thymidylate kinase tmk 0.165
5294 Nucleoside diphosphate kinase A NME1 0.1584
3669 Ribokinase rbsK 0.0662
2892 Acetylglutamate kinase argB 0.0658
3550 Acetylglutamate kinase argB 0.0658
6390 Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 ATP2A1 0.0624
6447 Guanine nucleotide-binding protein G(t) subunit alpha-1 GNAT1 0.0595
702 UMP-CMP kinase CMPK1 0.0559
6395 Myosin-14 MYH14 0.0546
1830 5'-nucleotidase NT5E 0.0485
3611 Cytidine deaminase cdd 0.0452
3707 Cytidine deaminase cdd 0.0452
4211 Cytidine deaminase CDA 0.0452
4773 Deoxycytidine kinase DCK 0.0427
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0356
6148 Multidrug resistance-associated protein 7 ABCC10 0.0304
6144 Solute carrier family 22 member 2 SLC22A2 0.0228
6145 Solute carrier family 22 member 1 SLC22A1 0.0223
4512 Cytochrome P450 3A4 CYP3A4 0.015
5293 Shikimate kinase 2 aroL 0.012
5314 UPF0079 ATP-binding protein HI0065 HI_0065 0.012
3199 Phosphopantetheine adenylyltransferase coaD 0.012
3543 Phosphopantetheine adenylyltransferase coaD 0.012
3567 Phosphopantetheine adenylyltransferase coaD 0.012
5289 Phosphopantetheine adenylyltransferase coaD 0.012
5288 Shikimate kinase aroK 0.012
5304 UPF0166 protein TM_0021 TM_0021 0.012
5283 D-alanine--D-alanine ligase B ddlB 0.012
5287 Signaling protein Not Available 0.012
5292 Putative partitioning protein TT_C1605 0.012
5276 Chromosomal replication initiator protein dnaA dnaA 0.012
5266 Activator of hgdC 0.012
2874 Nitrogenase iron protein 1 nifH1 0.012
4346 Polynucleotide kinase pseT 0.012
5281 Plasmid segregation protein parM parM 0.012
5305 Phosphoribosylaminoimidazole carboxylase ATPase subunit purK 0.012
5299 D-alanine--D-alanine ligase ddl 0.012
6598 D-alanine--D-alanine ligase ddl 0.012
5259 Transcriptional regulator ntrC1 0.012
6699 Transcriptional regulator Cgl2612 0.012
5290 ATP-dependent hsl protease ATP-binding subunit hslU hslU 0.012
5638 ATP-dependent hsl protease ATP-binding subunit hslU hslU 0.012
5270 ATP-dependent Clp protease ATP-binding subunit clpX clpX 0.012
5284 Large T antigen Not Available 0.012
5291 Glycogen synthase 1 glgA1 0.012
4794 Phosphoenolpyruvate carboxykinase [ATP] pckA 0.012
5275 Multidrug resistance ABC transporter ATP-binding and permease protein lmrA 0.012
5285 Kinesin heavy chain KIF5B 0.012
5315 Chaperone protein htpG htpG 0.012
1549 Heat shock 70 kDa protein 1 HSPA1A 0.012
5264 DNA replication protein REP 0.012
3777 ATP-dependent Clp protease ATP-binding subunit clpA clpA 0.012
5277 Preprotein translocase subunit secA secA 0.012
5308 Preprotein translocase secA 1 subunit secA1 0.012
3982 Phosphoribosylformylglycinamidine synthase PFAS 0.012
5261 Phosphoribosylformylglycinamidine synthase purL 0.012
4837 Cag-alfa cag-alfa 0.0104
4838 PMS1 protein homolog 2 PMS2 0.0104
4839 DNA polymerase III subunit tau dnaX 0.0104
3390 Aminoglycoside 3'-phosphotransferase aphA 0.0103
6029 Aminoglycoside 3'-phosphotransferase aphA1 0.0103
5646 Galactokinase GALK1 0.0103
5302 TrwB trwB 0.0103
5265 FtsH ftsH 0.0103
413 Amidophosphoribosyltransferase PPAT 0.0102
2515 Amidophosphoribosyltransferase purF 0.0102
3714 Amidophosphoribosyltransferase purF 0.0102
4106 Guanylate kinase GUK1 0.0102
4516 Guanylate kinase gmk 0.0102
2270 Dephospho-CoA kinase coaE 0.0102
4774 NTPase P4 Not Available 0.0102
2284 Adenylate kinase adk 0.0101
2296 Adenylate kinase adk 0.0101
2311 Adenylate kinase adk 0.0101
2312 Adenylate kinase Not Available 0.0101
340 Apoptotic protease-activating factor 1 APAF1 0.0101
5189 Trimethylamine dehydrogenase tmd 0.0101
6277 Heat shock cognate 71 kDa protein HSPA8 0.0101
3470 Hypothetical protein MG245 homolog MPN_348 0.0099
3426 Glutamine synthetase glnA 0.0098
3987 Glutamine synthetase GLUL 0.0098
5295 2-keto-3-deoxy-gluconate kinase TT_P0036 0.0098
2751 Holliday junction ATP-dependent DNA helicase ruvB ruvB 0.0098
4755 Holliday junction ATP-dependent DNA helicase ruvB ruvB 0.0098
3175 Glutamate--cysteine ligase gshA 0.0098
5312 Kinesin-like protein KIF1A KIF1A 0.0094
2390 Nonsecretory ribonuclease RNASE2 0.0094
2922 Glycerol kinase glpK 0.0092
2683 Mono-ADP-ribosyltransferase C3 C3 0.0092
5300 Antigen peptide transporter 1 TAP1 0.009
5271 Focal adhesion kinase 1 PTK2 0.0089
2615 Chemotaxis protein cheA cheA 0.0088
408 Riboflavin kinase RFK 0.0088
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0086
2371 Pantothenate kinase coaA 0.0086
1881 Hexokinase-1 HK1 0.0086
2950 Inositol-trisphosphate 3-kinase A ITPKA 0.0086
825 Arsenical pump-driving ATPase ASNA1 0.0084
3435 Arsenical pump-driving ATPase arsA 0.0084
4366 Riboflavin kinase/FMN adenylyltransferase TM_0857 0.0084
6832 Serine/threonine-protein kinase SRPK2 SRPK2 0.0083
6857 [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 2, mitochondrial PDK2 0.0083
2727 S-adenosylmethionine synthetase metK 0.0083
2817 Phosphoribosylglycinamide formyltransferase 2 purT 0.008
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0079
2697 Uridine-cytidine kinase 2 UCK2 0.0079
788 Creatine kinase M-type CKM 0.0079
2334 Dethiobiotin synthetase bioD 0.0075
6555 Dethiobiotin synthetase bioD 0.0075
61 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0075
2644 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0075
2710 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0075
453 S-adenosylmethionine synthetase isoform type-1 MAT1A 0.0075
48 Pyridoxal kinase PDXK 0.0073
201 Glutamate dehydrogenase 1, mitochondrial GLUD1 0.0073
2511 MAP kinase-activated protein kinase 2 MAPKAPK2 0.0071
2091 Endoplasmin HSP90B1 0.007
2317 UDP-N-acetylmuramoylalanine--D-glutamate ligase murD 0.007
207 Glutathione synthetase GSS 0.0069
5269 Glutathione synthetase gshB 0.0069
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0068
1422 Serine/threonine-protein kinase 6 AURKA 0.0067
3379 Kinesin-like protein KIF11 KIF11 0.0065
3456 Heat shock protein HSP 90-beta HSP90AB1 0.0064
3822 Actin, alpha skeletal muscle ACTA1 0.0064
509 Thymidine kinase TK 0.0063
570 Thymidine kinase TK 0.0063
2559 Thymidine kinase TK 0.0063
3430 Thymidine kinase tdk 0.0063
3518 Thymidine kinase TK 0.0063
5301 Thymidine kinase tdk 0.0063
5771 Thymidine kinase ORF36 0.0063
7009 Thymidine kinase ORF36 0.0063
504 Mast/stem cell growth factor receptor KIT 0.0063
1721 Glycogen synthase kinase-3 beta GSK3B 0.0058
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0057
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0057
5682 Ribonuclease pancreatic RNASE1 0.0056
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.005
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