DT-Web

DB03664 - P1-(Adenosine-5'-P5-(Uridine-5')Pentaphosphate


Identification
Name P1-(Adenosine-5'-P5-(Uridine-5')Pentaphosphate
Accession Number DB03664 (EXPT03194)
Type small molecule
Description Not Available
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 893.3269
Groups experimental
Monoisotopic Weight 892.987377419
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


UMP-CMP kinase
Name UMP-CMP kinase
Gene Name CMPK1
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 0.399

Predictions


Id Partner name Gene Name Score
3669 Ribokinase rbsK 0.0385
2892 Acetylglutamate kinase argB 0.0382
3550 Acetylglutamate kinase argB 0.0382
3779 Alpha-2,3/8-sialyltransferase cst-II 0.0381
6447 Guanine nucleotide-binding protein G(t) subunit alpha-1 GNAT1 0.0369
6390 Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 ATP2A1 0.0363
3692 Coenzyme A biosynthesis bifunctional protein coaBC coaBC 0.0329
4773 Deoxycytidine kinase DCK 0.0322
3188 IspD/ispF bifunctional enzyme [Includes: 2-C-methyl-D-erythritol 4- phosphate cytidylyltransferase ispDF 0.0319
6395 Myosin-14 MYH14 0.0318
2909 Cytidylate kinase cmk 0.0289
2697 Uridine-cytidine kinase 2 UCK2 0.0287
3523 Spore coat polysaccharide biosynthesis protein spsA spsA 0.0281
2765 3-deoxy-manno-octulosonate cytidylyltransferase kpsU 0.027
3120 3-deoxy-manno-octulosonate cytidylyltransferase kdsB 0.027
2383 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase ispF 0.0258
2937 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase ispF 0.0258
4620 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase ispF 0.0258
6594 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase ispF 0.0258
6609 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase ispF 0.0258
6646 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase ispF 0.0258
4482 UDP-galactose 4-epimerase galE 0.0253
3524 DNA beta-glucosyltransferase bgt 0.0243
3408 Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3 B3GAT3 0.0242
2608 UDP-N-acetylglucosamine 2-epimerase wecB 0.0242
3611 Cytidine deaminase cdd 0.024
3707 Cytidine deaminase cdd 0.024
4211 Cytidine deaminase CDA 0.024
2291 Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1 B3GAT1 0.0237
2590 Galactose-1-phosphate uridylyltransferase galT 0.0225
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.0218
6171 Solute carrier family 28 member 3 SLC28A3 0.0213
2439 Alpha,alpha-trehalose-phosphate synthase [UDP-forming] otsA 0.0209
2555 Pol polyprotein pol 0.0191
3242 Pol polyprotein gag-pol 0.0191
3471 Pol polyprotein gag-pro-pol 0.0191
5256 Pol polyprotein pol 0.0191
6469 Pol polyprotein gag-pol 0.0191
6565 Pol polyprotein Not Available 0.0191
2762 UDP-glucose 4-epimerase GALE 0.019
3461 UDP-glucose 4-epimerase galE 0.019
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0189
24 Thymidylate synthase TMP1 0.0179
359 Thymidylate synthase TYMS 0.0179
2626 Thymidylate synthase thyA 0.0179
2729 Thymidylate synthase thyA 0.0179
5352 Thymidylate synthase THYA 0.0179
6148 Multidrug resistance-associated protein 7 ABCC10 0.0164
237 Histo-blood group ABO system transferase ABO 0.0163
342 P protein [Includes: DNA-directed DNA polymerase P 0.0159
612 P protein [Includes: DNA-directed DNA polymerase P 0.0159
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0144
1588 Multidrug resistance protein 1 ABCB1 0.0143
5626 Nucleoside diphosphate kinase B NME2 0.0133
5294 Nucleoside diphosphate kinase A NME1 0.0132
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0081
6147 Solute carrier family 22 member 3 SLC22A3 0.0079
2164 Multidrug resistance-associated protein 4 ABCC4 0.0075
862 Multidrug resistance-associated protein 1 ABCC1 0.0072
6144 Solute carrier family 22 member 2 SLC22A2 0.0069
6145 Solute carrier family 22 member 1 SLC22A1 0.0068
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0067
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0066
1729 Solute carrier family 22 member 6 SLC22A6 0.0061
5314 UPF0079 ATP-binding protein HI0065 HI_0065 0.0034
3199 Phosphopantetheine adenylyltransferase coaD 0.0034
3543 Phosphopantetheine adenylyltransferase coaD 0.0034
3567 Phosphopantetheine adenylyltransferase coaD 0.0034
5289 Phosphopantetheine adenylyltransferase coaD 0.0034
5304 UPF0166 protein TM_0021 TM_0021 0.0034
5287 Signaling protein Not Available 0.0034
5292 Putative partitioning protein TT_C1605 0.0034
2874 Nitrogenase iron protein 1 nifH1 0.0034
5283 D-alanine--D-alanine ligase B ddlB 0.0034
5293 Shikimate kinase 2 aroL 0.0034
5288 Shikimate kinase aroK 0.0034
5281 Plasmid segregation protein parM parM 0.0034
5305 Phosphoribosylaminoimidazole carboxylase ATPase subunit purK 0.0034
5276 Chromosomal replication initiator protein dnaA dnaA 0.0034
5315 Chaperone protein htpG htpG 0.0034
5259 Transcriptional regulator ntrC1 0.0034
6699 Transcriptional regulator Cgl2612 0.0034
5290 ATP-dependent hsl protease ATP-binding subunit hslU hslU 0.0034
5638 ATP-dependent hsl protease ATP-binding subunit hslU hslU 0.0034
5284 Large T antigen Not Available 0.0034
5266 Activator of hgdC 0.0034
5291 Glycogen synthase 1 glgA1 0.0034
4346 Polynucleotide kinase pseT 0.0034
5275 Multidrug resistance ABC transporter ATP-binding and permease protein lmrA 0.0034
1549 Heat shock 70 kDa protein 1 HSPA1A 0.0034
5299 D-alanine--D-alanine ligase ddl 0.0034
6598 D-alanine--D-alanine ligase ddl 0.0034
3777 ATP-dependent Clp protease ATP-binding subunit clpA clpA 0.0034
5270 ATP-dependent Clp protease ATP-binding subunit clpX clpX 0.0034
3982 Phosphoribosylformylglycinamidine synthase PFAS 0.0034
5261 Phosphoribosylformylglycinamidine synthase purL 0.0034
5277 Preprotein translocase subunit secA secA 0.0034
5308 Preprotein translocase secA 1 subunit secA1 0.0034
5264 DNA replication protein REP 0.0034
4794 Phosphoenolpyruvate carboxykinase [ATP] pckA 0.0034
5285 Kinesin heavy chain KIF5B 0.0034
4106 Guanylate kinase GUK1 0.0028
4516 Guanylate kinase gmk 0.0028
413 Amidophosphoribosyltransferase PPAT 0.0028
2515 Amidophosphoribosyltransferase purF 0.0028
3714 Amidophosphoribosyltransferase purF 0.0028
6277 Heat shock cognate 71 kDa protein HSPA8 0.0028
3390 Aminoglycoside 3'-phosphotransferase aphA 0.0028
6029 Aminoglycoside 3'-phosphotransferase aphA1 0.0028
5302 TrwB trwB 0.0028
4837 Cag-alfa cag-alfa 0.0028
4774 NTPase P4 Not Available 0.0028
5265 FtsH ftsH 0.0028
5646 Galactokinase GALK1 0.0028
4838 PMS1 protein homolog 2 PMS2 0.0028
4839 DNA polymerase III subunit tau dnaX 0.0028
2284 Adenylate kinase adk 0.0028
2296 Adenylate kinase adk 0.0028
2311 Adenylate kinase adk 0.0028
2312 Adenylate kinase Not Available 0.0028
2270 Dephospho-CoA kinase coaE 0.0028
5295 2-keto-3-deoxy-gluconate kinase TT_P0036 0.0028
2751 Holliday junction ATP-dependent DNA helicase ruvB ruvB 0.0028
4755 Holliday junction ATP-dependent DNA helicase ruvB ruvB 0.0028
5189 Trimethylamine dehydrogenase tmd 0.0028
3470 Hypothetical protein MG245 homolog MPN_348 0.0028
3175 Glutamate--cysteine ligase gshA 0.0028
3426 Glutamine synthetase glnA 0.0028
3987 Glutamine synthetase GLUL 0.0028
2683 Mono-ADP-ribosyltransferase C3 C3 0.0026
340 Apoptotic protease-activating factor 1 APAF1 0.0026
2390 Nonsecretory ribonuclease RNASE2 0.0026
5312 Kinesin-like protein KIF1A KIF1A 0.0026
2922 Glycerol kinase glpK 0.0026
5271 Focal adhesion kinase 1 PTK2 0.0025
5300 Antigen peptide transporter 1 TAP1 0.0025
2282 Protein recA recA 0.0024
2315 Protein recA recA 0.0024
2332 Protein recA recA 0.0024
5263 Protein recA recA 0.0024
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0024
2615 Chemotaxis protein cheA cheA 0.0024
1881 Hexokinase-1 HK1 0.0024
2371 Pantothenate kinase coaA 0.0024
408 Riboflavin kinase RFK 0.0024
2950 Inositol-trisphosphate 3-kinase A ITPKA 0.0024
825 Arsenical pump-driving ATPase ASNA1 0.0024
3435 Arsenical pump-driving ATPase arsA 0.0024
4366 Riboflavin kinase/FMN adenylyltransferase TM_0857 0.0024
6857 [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 2, mitochondrial PDK2 0.0024
6832 Serine/threonine-protein kinase SRPK2 SRPK2 0.0023
2727 S-adenosylmethionine synthetase metK 0.0023
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0022
788 Creatine kinase M-type CKM 0.0022
2817 Phosphoribosylglycinamide formyltransferase 2 purT 0.0022
2334 Dethiobiotin synthetase bioD 0.0021
6555 Dethiobiotin synthetase bioD 0.0021
61 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0021
2644 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0021
2710 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0021
453 S-adenosylmethionine synthetase isoform type-1 MAT1A 0.002
2251 Thymidylate kinase tmk 0.002
2254 Thymidylate kinase DTYMK 0.002
3522 Thymidylate kinase tmk 0.002
2511 MAP kinase-activated protein kinase 2 MAPKAPK2 0.002
48 Pyridoxal kinase PDXK 0.002
2317 UDP-N-acetylmuramoylalanine--D-glutamate ligase murD 0.002
2091 Endoplasmin HSP90B1 0.002
201 Glutamate dehydrogenase 1, mitochondrial GLUD1 0.002
1422 Serine/threonine-protein kinase 6 AURKA 0.0019
207 Glutathione synthetase GSS 0.0019
5269 Glutathione synthetase gshB 0.0019
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0019
3379 Kinesin-like protein KIF11 KIF11 0.0018
3456 Heat shock protein HSP 90-beta HSP90AB1 0.0018
3822 Actin, alpha skeletal muscle ACTA1 0.0018
509 Thymidine kinase TK 0.0018
570 Thymidine kinase TK 0.0018
2559 Thymidine kinase TK 0.0018
3430 Thymidine kinase tdk 0.0018
3518 Thymidine kinase TK 0.0018
5301 Thymidine kinase tdk 0.0018
5771 Thymidine kinase ORF36 0.0018
7009 Thymidine kinase ORF36 0.0018
504 Mast/stem cell growth factor receptor KIT 0.0017
1721 Glycogen synthase kinase-3 beta GSK3B 0.0017
5682 Ribonuclease pancreatic RNASE1 0.0016
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0015
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0015
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0014
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