Partner ID 3188
Name IspD/ispF bifunctional enzyme [Includes: 2-C-methyl-D-erythritol 4- phosphate cytidylyltransferase
Synonyms 4220
Gene name ispDF
General function Lipid transport and metabolism
Specific function Bifunctional enzyme that catalyzes the formation of 4- diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl- D-erythritol 4-phosphate (MEP) (ispD), and converts 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate into 2-C- methyl-D-erythritol 2,4-cyclodiphosphate (MECDP) and CMP (ispF)
Gene sequence + ...

ATGAGTGAAATGAGCCTCATTATGTTAGCAGCTGGAAATTCTACTCGTTTTAATACAAAGGTAAAAAAACAATTTTTACGACTTGGAAATGACCCTCTTTGGCTTTATGCAACAAAAAATTTAAGCTCTTTTTATCCTTTTAAAAAAATAGTTGTTACCTCTAGTAATATCACTTATATGAAAAAATTTACCAAAAACTATGAATTCATAGAAGGTGGTGATACCAGAGCAGAATCCTTAAAAAAAGCCTTAGAGCTCATAGATAGCGAATTTGTTATGGTAAGTGATGTAGCAAGGGTATTGGTGAGTAAAAATTTGTTTGATCGTTTGATTGAAAATTTAGATAAAGCAGATTGTATTACCCCTGCTTTAAAAGTTGCAGATACAACACTTTTTGACAATGAAGCCTTGCAAAGAGAAAAAATCAAACTCATTCAAACCCCGCAAATTTCTAAAACCAAATTGCTTAAAAAAGCCTTGGATCAAAACCTAGAATTTACAGATGATAGCACAGCTATAGCTGCAATGGGTGGAAAAATTTGGTTTGTTGAAGGTGAAGAAAATGCAAGAAAACTAACCTTTAAAGAAGATCTTAAAAAACTTGATTTGCCTACACCTAGCTTTGAAATTTTTACTGGCAATGGTTTTGATGTGCATGAATTTGGAGAGAATCGCCCTTTGCTTTTAGCAGGAGTGCAAATTCATCCTACTATGGGGCTTAAAGCACACAGCGATGGAGATGTTTTAGCTCACTCTTTAACCGATGCGATTTTAGGTGCTGCAGGACTTGGAGATATAGGAGAGCTTTATCCTGATACTGATATGAAATTTAAAAATGCCAACTCCATGGAGCTTTTAAAACAAGCTTATGATAAAGTCAGAGAAATAGGTTTTGAACTCATTAATATAGACATTTGCGTCATGGCACAAAGCCCTAAACTTAAAGACTTTAAACAAGCTATGCAAAGCAATATAGCTCATACTTTAGATTTAGATGAATTTAGAATCAATGTTAAAGCCACAACAACGGAAAAATTGGGTTTTATTGGAAGAAAAGAAGGTATGGCGGTGCTTAGTAGTGTAAATTTAAAATATTTTGATTGGACAAGATTATGA

Protein sequence + ...

MSEMSLIMLAAGNSTRFNTKVKKQFLRLGNDPLWLYATKNLSSFYPFKKIVVTSSNITYMKKFTKNYEFIEGGDTRAESLKKALELIDSEFVMVSDVARVLVSKNLFDRLIENLDKADCITPALKVADTTLFDNEALQREKIKLIQTPQISKTKLLKKALDQNLEFTDDSTAIAAMGGKIWFVEGEENARKLTFKEDLKKLDLPTPSFEIFTGNGFDVHEFGENRPLLLAGVQIHPTMGLKAHSDGDVLAHSLTDAILGAAGLGDIGELYPDTDMKFKNANSMELLKQAYDKVREIGFELINIDICVMAQSPKLKDFKQAMQSNIAHTLDLDEFRINVKATTTEKLGFIGRKEGMAVLSSVNLKYFDWTRL

GO Classification
function
nucleotidyltransferase activity
phosphorus-oxygen lyase activity
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
catalytic activity
lyase activity
transferase activity
4-diphosphocytidyl-2C-methyl-D-erythritol synthase activity
transferase activity, transferring phosphorus-containing groups
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
process
cellular lipid metabolism
isoprenoid metabolism
isoprenoid biosynthesis
physiological process
polyisoprenoid metabolism
metabolism
terpenoid metabolism
terpenoid biosynthesis
primary metabolism
lipid metabolism
See more information at   →   www.drugbank.ca
Id Name
DB00282 Pamidronate
DB00399 Zoledronate
DB00441 Gemcitabine
DB00630 Alendronate
DB00709 Lamivudine
DB00710 Ibandronate
DB00884 Risedronate
DB01785 Dimethylallyl Diphosphate
DB01859 4-Diphosphocytidyl-2-C-Methyl-D-Erythritol 2-Phosphate
DB02097 Cytidine
DB02344 O-Sialic Acid (Chair Conformation)
DB02431 Cytidine-5'-Triphosphate
DB02456 Cytosine Arabinose-5'-Phosphate
DB02508 Isopentyl Pyrophosphate
DB02521 2,5,7-Trihydroxynaphthoquinone
DB02552 Geranyl Diphosphate
DB02883 2',3'-Dideoxycytidine-5'-Monophosphate
DB03403 Cytidine-5'-Monophosphate
DB03431 Adenosine-5'-Diphosphate
DB03435 Uridine-5'-Diphosphate
DB03664 P1-(Adenosine-5'-P5-(Uridine-5')Pentaphosphate
DB03687 4-Diphosphocytidyl-2-C-Methyl-D-Erythritol
DB03961 2c-Methyl-D-Erythritol 2,4-Cyclodiphosphate
DB04005 Uridine 5'-Triphosphate
DB04272 Citric Acid
DB04444 Tetrafluoroaluminate Ion
DB04482 Cmp-2-Keto-3-Deoxy-Octulosonic Acid
DB04555 Cytidine-5'-Diphosphate
DB04695 FARNESYL THIOPYROPHOSPHATE
DB04702 S-[(2E)-3,7-DIMETHYLOCTA-2,6-DIENYL] TRIHYDROGENTHIODIPHOSPHATE
DB04714 ISOPENTENYL PYROPHOSPHATE
DB06830 (1-HYDROXYHEPTANE-1,1-DIYL)BIS(PHOSPHONIC ACID)
DB06931 (1-HYDROXYNONANE-1,1-DIYL)BIS(PHOSPHONIC ACID)
DB07221 (2,2-DIPHOSPHONOETHYL)(DODECYL)DIMETHYLPHOSPHONIUM
DB07410 [2-(3-DIBENZOFURAN-4-YL-PHENYL)-1-HYDROXY-1-PHOSPHONO-ETHYL]-PHOSPHONIC ACID
DB07661 1,6-DIHYDROXY NAPHTHALENE
DB07780 FARNESYL DIPHOSPHATE
DB07841 GERANYLGERANYL DIPHOSPHATE
DB07873 (1-HYDROXYDODECANE-1,1-DIYL)BIS(PHOSPHONIC ACID)
DB08529 (6E,11E)-HEPTADECA-6,11-DIENE-9,9-DIYLBIS(PHOSPHONIC ACID)