DT-Web

DB02508 - Isopentyl Pyrophosphate


Identification
Name Isopentyl Pyrophosphate
Accession Number DB02508 (EXPT01922)
Type small molecule
Description Not Available
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 248.108
Groups experimental
Monoisotopic Weight 248.021475826
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Geranyltranstransferase
Name Geranyltranstransferase
Gene Name ispA
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 1.1256
Farnesyl pyrophosphate synthetase
Name Farnesyl pyrophosphate synthetase
Gene Name FDPS
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 0.9802
Pentaerythritol tetranitrate reductase
Name Pentaerythritol tetranitrate reductase
Gene Name onr
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 1.9486
Geranyltranstransferase (Farnesyldiphosphate synthase)
Name Geranyltranstransferase (Farnesyldiphosphate synthase)
Gene Name ispA
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 0.8491

Predictions


Id Partner name Gene Name Score
6553 Isopentenyl transferase tzs 0.3539
6058 Geranylgeranyl pyrophosphate synthetase GGPS1 0.1179
6548 4-hydroxy-3-methylbut-2-enyl diphosphate reductase ispH 0.097
2632 Adenylosuccinate synthetase purA 0.0946
3323 Adenylosuccinate synthetase purA 0.0946
3975 Adenylosuccinate synthetase ADSS 0.0946
4598 Adenylosuccinate synthetase Adss 0.0946
6817 Adenylosuccinate synthetase purA 0.0946
2434 NH(3)-dependent NAD(+) synthetase nadE 0.0894
2910 NH(3)-dependent NAD(+) synthetase nadE 0.0894
3217 NH(3)-dependent NAD(+) synthetase nadE 0.0894
2586 Isopentenyl-diphosphate Delta-isomerase idi 0.0855
5187 Isopentenyl-diphosphate delta-isomerase fni 0.0855
5199 Isopentenyl-diphosphate delta-isomerase fni 0.0855
2251 Thymidylate kinase tmk 0.0761
2254 Thymidylate kinase DTYMK 0.0761
3522 Thymidylate kinase tmk 0.0761
6547 Isopentenyl-diphosphate Delta-isomerase 1 IDI1 0.0696
2427 Ferrichrome-iron receptor fhuA 0.0661
6596 Short-chain Z-isoprenyl diphosphate synthetase Rv1086 0.0423
5744 Undecaprenyl pyrophosphate synthetase uppS 0.0421
6056 Receptor-type tyrosine-protein phosphatase epsilon PTPRE 0.0369
1376 Tyrosine-protein phosphatase non-receptor type 4 PTPN4 0.0369
6576 Geranylgeranyl transferase type-2 subunit beta RABGGTB 0.0365
6575 Geranylgeranyl transferase type-2 subunit alpha RABGGTA 0.0365
290 Prostaglandin G/H synthase 2 PTGS2 0.0349
6055 Receptor-type tyrosine-protein phosphatase S PTPRS 0.0322
4128 Protein farnesyltransferase subunit beta FNTB 0.0305
6057 V-type proton ATPase catalytic subunit A ATP6V1A 0.0301
4129 Protein farnesyltransferase/geranylgeranyltransferase type I alpha subunit FNTA 0.0299
3188 IspD/ispF bifunctional enzyme [Includes: 2-C-methyl-D-erythritol 4- phosphate cytidylyltransferase ispDF 0.0259
862 Multidrug resistance-associated protein 1 ABCC1 0.024
1994 Geranylgeranyl transferase type-1 subunit beta PGGT1B 0.0237
6540 Prenyltransferase Not Available 0.0224
2383 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase ispF 0.0208
2937 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase ispF 0.0208
4620 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase ispF 0.0208
6594 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase ispF 0.0208
6609 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase ispF 0.0208
6646 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase ispF 0.0208
6595 Lantibiotic nisin-Z nisZ 0.0189
6574 GTPase KRas KRAS 0.0151
5191 Morphinone reductase morB 0.0068
5198 Flavodoxin-1 fldA 0.0068
5170 Epidermin decarboxylase epiD 0.0068
5175 Hypothetical protein SMU.260 SMU_260 0.0068
5197 Trp repressor binding protein WrbA, putative DR_A0214 0.0068
5200 NADH dehydrogenase nox 0.0068
5131 PhzG phzG 0.0068
5201 FMN-binding protein DvMF_2023 0.0068
5193 Phenazine biosynthesis protein phzG phzG 0.0068
5178 Protein nrdI nrdI 0.0068
3293 Flavodoxin Not Available 0.0068
4614 Flavodoxin DVU_2680 0.0068
5172 Flavodoxin isiB 0.0068
5173 Flavodoxin isiB 0.0068
5182 Flavodoxin fldA 0.0068
4037 Hypothetical protein GPX1 0.0068
4297 Hypothetical protein SP_1951 0.0068
4521 Hypothetical protein BC_2969 0.0068
4540 Hypothetical protein TM_1070 0.0068
4555 Hypothetical protein MT1739 0.0068
4569 Hypothetical protein mshD 0.0068
4578 Hypothetical protein PA3270 0.0068
4747 Hypothetical protein PA3967 0.0068
5177 Hypothetical protein TM_0096 0.0068
5194 Hypothetical protein PA1204 0.0068
5240 Hypothetical protein Rv2991 0.0068
5370 Hypothetical protein TM_1158 0.0068
5710 Hypothetical protein Tb927.5.1360 0.0068
5181 Hypothetical protein yhdA azr 0.0068
5179 Probable aromatic acid decarboxylase pad1 0.0068
5202 Nitroreductase family protein BC_1844 0.0068
4405 Nitric oxide reductase fprA 0.0068
5190 Rubredoxin-oxygen oxidoreductase roo 0.0068
4407 FMN-dependent NADH-azoreductase azoR 0.0059
5169 FMN-dependent NADH-azoreductase azoR 0.0059
5189 Trimethylamine dehydrogenase tmd 0.0059
4503 NADPH-flavin oxidoreductase frp 0.0059
3680 Dihydroorotate dehydrogenase A pyrDA 0.0059
5206 Phosphopantothenoylcysteine decarboxylase PPCDC 0.0059
3766 Pyridoxamine 5'-phosphate oxidase pdxH 0.0059
3507 Chorismate synthase aroC 0.0059
5171 Chorismate synthase aroC 0.0059
5176 YtnJ moxC 0.0059
4836 Ferredoxin-dependent glutamate synthase 2 gltS 0.0059
6608 Serine/threonine-protein kinase Sgk1 SGK1 0.0054
2775 Dihydroorotate dehydrogenase pyrD 0.0054
5180 L(+)-mandelate dehydrogenase mdlB 0.0051
4366 Riboflavin kinase/FMN adenylyltransferase TM_0857 0.0051
3573 2,4-dienoyl-CoA reductase [NADPH] fadH 0.0051
408 Riboflavin kinase RFK 0.0048
685 Oxygen-insensitive NADPH nitroreductase nfsA 0.0048
6945 Oxygen-insensitive NADPH nitroreductase rdxA 0.0048
2261 Major NAD(P)H-flavin oxidoreductase Not Available 0.0048
2936 Oxygen-insensitive NAD(P)H nitroreductase nfnB 0.0047
5184 Oxygen-insensitive NAD(P)H nitroreductase nfnB 0.0047
203 Pyridoxine-5'-phosphate oxidase PNPO 0.0047
6268 Hydroxyacid oxidase 1 HAO1 0.0043
654 Flavin reductase BLVRB 0.0041
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.004
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0035
76 Nitric-oxide synthase, brain NOS1 0.0034
4120 NADPH--cytochrome P450 reductase POR 0.0031
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