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Geranylgeranyl transferase type-2 subunit alpha


Partner ID 6575
Name Geranylgeranyl transferase type-2 subunit alpha
Synonyms 8814
Gene name RABGGTA
General function Involved in protein binding
Specific function Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to both cysteines in Rab proteins with an -XXCC, -XCXC and -CCXX C-terminal, such as RAB1A, RAB3A and RAB5A respectively
Gene sequence + ...

ATGCACGGACGCCTGAAGGTGAAGACGTCAGAAGAGCAGGCGGAGGCCAAAAGGCTAGAGCGAGAGCAGAAGCTGAAGCTATACCAGTCAGCCACCCAGGCCGTATTCCAGAAGCGCCAGGCTGGTGAGCTGGATGAGTCCGTGCTGGAACTGACAAGCCAGATTCTGGGAGCCAACCCTGATTTTGCCACCCTCTGGAACTGCCGACGAGAGGTGCTCCAGCAGCTGGAGACTCAGAAGTCTCCTGAAGAGTTGGCTGCTCTGGTGAAGGCAGAACTGGGCTTCCTGGAGAGCTGCCTGCGGGTGAACCCCAAGTCTTATGGTACCTGGCACCACCGATGCTGGCTGCTAGGCCGCCTGCCTGAGCCCAACTGGACCCGAGAGCTGGAGCTCTGTGCCCGTTTCCTGGAGGTGGATGAGCGGAACTTTCACTGCTGGGACTATCGGCGGTTTGTGGCCACACAGGCAGCCGTGCCCCCTGCAGAAGAGCTAGCCTTCACTGACAGCCTCATCACCCGAAACTTCTCCAACTACTCTTCCTGGCATTACCGCTCCTGTCTCTTGCCCCAGTTGCACCCCCAGCCGGATTCTGGACCACAGGGGCGCCTCCCTGAGGATGTGCTGCTCAAAGAGCTGGAGCTGGTGCAGAATGCCTTCTTCACTGACCCCAATGACCAGAGTGCCTGGTTTTATCACCGGTGGCTCCTAGGTCGAGCTGACCCCCAGGATGCACTGCGCTGTCTGCATGTGAGCCGGGACGAGGCCTGTCTGACTGTCTCCTTCTCTCGGCCCCTCTTAGTGGGCTCCAGGATGGAGATCTTGCTGCTCATGGTTGATGATTCTCCCCTGATTGTGGAGTGGAGGACCCCAGATGGCAGGAACCGGCCCAGCCATGTCTGGCTCTGTGACCTGCCTGCTGCCTCCCTCAACGACCAGTTGCCCCAACATACATTTCGCGTCATTTGGACAGCAGGCGATGTCCAGAAAGAATGCGTGCTTTTAAAAGGCCGCCAGGAGGGCTGGTGCCGGGACTCCACGACAGACGAGCAGCTATTCAGGTGTGAGCTGTCAGTGGAGAAGTCCACAGTGCTGCAGTCTGAGCTGGAATCCTGTAAGGAGCTGCAGGAGCTGGAGCCTGAGAATAAATGGTGCCTGCTTACCATCATCCTGCTGATGCGGGCACTGGACCCCCTGCTGTATGAGAAGGAGACCCTGCAGTACTTCCAGACCCTCAAGGCCGTGGACCCCATGCGGGCAACGTATCTGGATGACCTGCGCAGCAAGTTCTTGCTGGAGAATAGCGTGCTCAAGATGGAGTATGCCGAGGTGCGTGTGCTGCACCTGGCTCACAAGGATCTGACAGTGCTCTGCCATCTGGAACAGCTGCTCTTGGTCACCCATCTTGACTTGTCACACAATCGCCTCCGAACCCTGCCACCTGCACTGGCTGCCCTGCGCTGCCTTGAGGTGCTGCAGGCCAGTGATAATGCAATAGAGTCCCTGGACGGCGTCACCAACCTACCCCGGCTGCAGGAGCTGCTACTGTGCAACAACCGCCTCCAGCAGCCTGCAGTGCTCCAGCCTCTTGCCTCCTGCCCCAGGCTGGTCCTCCTCAACCTGCAGGGTAACCCGCTGTGCCAAGCGGTGGGCATCTTGGAGCAACTGGCTGAACTGCTGCCTTCAGTTAGCAGCGTCCTCACCTAA
Protein sequence + ...

MHGRLKVKTSEEQAEAKRLEREQKLKLYQSATQAVFQKRQAGELDESVLELTSQILGANPDFATLWNCRREVLQQLETQKSPEELAALVKAELGFLESCLRVNPKSYGTWHHRCWLLGRLPEPNWTRELELCARFLEVDERNFHCWDYRRFVATQAAVPPAEELAFTDSLITRNFSNYSSWHYRSCLLPQLHPQPDSGPQGRLPEDVLLKELELVQNAFFTDPNDQSAWFYHRWLLGRADPQDALRCLHVSRDEACLTVSFSRPLLVGSRMEILLLMVDDSPLIVEWRTPDGRNRPSHVWLCDLPAASLNDQLPQHTFRVIWTAGDVQKECVLLKGRQEGWCRDSTTDEQLFRCELSVEKSTVLQSELESCKELQELEPENKWCLLTIILLMRALDPLLYEKETLQYFQTLKAVDPMRATYLDDLRSKFLLENSVLKMEYAEVRVLHLAHKDLTVLCHLEQLLLVTHLDLSHNRLRTLPPALAALRCLEVLQASDNAIESLDGVTNLPRLQELLLCNNRLQQPAVLQPLASCPRLVLLNLQGNPLCQAVGILEQLAELLPSVSSVLT
GO Classification
function
prenyltransferase activity
protein prenyltransferase activity
catalytic activity
transferase activity
transferase activity, transferring alkyl or aryl (other than methyl) groups
process
protein amino acid lipidation
protein prenylation
physiological process
protein amino acid prenylation
metabolism
macromolecule metabolism
biopolymer metabolism
biopolymer modification
protein modification
See more information at   →   www.drugbank.ca

Drugs


Associated as Target

Id Name
DB04464 N-Formylmethionine
DB07752 FARNESYL
DB07780 FARNESYL DIPHOSPHATE
DB07841 GERANYLGERANYL DIPHOSPHATE

Associated as Prediction

Id Name
DB00128 L-Aspartic Acid
DB00157 NADH
DB00228 Enflurane
DB00282 Pamidronate
DB00399 Zoledronate
DB00407 Ardeparin
DB00536 Guanidine
DB00569 Fondaparinux sodium
DB00630 Alendronate
DB00710 Ibandronate
DB00753 Isoflurane
DB00768 Olopatadine
DB00884 Risedronate
DB01028 Methoxyflurane
DB01109 Heparin
DB01159 Halothane
DB01189 Desflurane
DB01225 Enoxaparin
DB01236 Sevoflurane
DB01373 Calcium
DB01785 Dimethylallyl Diphosphate
DB01812 Adenosine-3'-5'-Diphosphate
DB01842 3'-Phosphate-Adenosine-5'-Diphosphate
DB01942 Formic Acid
DB01961 Cytidine-3'-Monophosphate
DB02098 Adenosine-2'-5'-Diphosphate
DB02363 2'-Monophosphoadenosine-5'-Diphosphate
DB02508 Isopentyl Pyrophosphate
DB02552 Geranyl Diphosphate
DB02573 2'-Deoxycytidine-2'-Deoxyadenosine-3',5'-Monophosphate
DB02659 Cholic Acid
DB02674 4-(2-Oxo-Hexahydro-Thieno[3,4-D]Imidazol-4-Yl)-Butyricacid
DB02714 3'-Uridinemonophosphate
DB02740 3-Indolebutyric Acid
DB02805 1-(3-O-Phosphono-Beta-L-Arabinofuranosyl)Pyrimidine-2,4(1h,3h)-Dione
DB02899 N-Carboxymethionine
DB02944 Alpha-D-Mannose
DB02987 Cysteine-S-Acetamide
DB03112 6-(2-Oxo-Hexahydro-Thieno[3,4-D]Imidazol-4-Yl)-Hexanoic Acid
DB03139 6-[5-(2-Oxo-Hexahydro-Thieno[3,4-D]Imidazol-4-Yl)-Pentanoylamino]-Hexanoic Acid
DB03155 1-(2-Deoxy-2-Fluoro-3-O-Phosphono-Beta-L-Ribofuranosyl)Pyrimidine-2,4(1h,3h)-Dione
DB03186 U-Pi-a-Pi
DB03326 deoxycytidylyl-3',5'-guanosine
DB03353 2-Iminobiotin
DB03431 Adenosine-5'-Diphosphate
DB03447 Uridylyl-2'-5'-Phospho-Adenosine
DB03448 2'-Deoxyuridine 3'-Monophosphate
DB03512 Uridine-2',3'-Vanadate
DB03533 Glycoluril
DB03549 Biotinyl P-Nitroaniline
DB03726 Purine Riboside-5'-Monophosphate
DB03765 Cytidine-2'-Monophosphate
DB03792 5-Amino-1h-Pyrimidine-2,4-Dione
DB03900 2-Methyl-2-Propanol
DB04147 Lauryl Dimethylamine-N-Oxide
DB04272 Citric Acid
DB04464 N-Formylmethionine
DB04514 Phosphoric Acid-2'-[2'-Deoxy-Uridine]Ester-5'-Guanosine Ester
DB04650 5-[(3AS,4R,6AR)-2-OXOHEXAHYDRO-1H-THIENO[3,4-D]IMIDAZOL-4-YL]PENTANOIC ACID
DB04695 FARNESYL THIOPYROPHOSPHATE
DB04714 ISOPENTENYL PYROPHOSPHATE
DB06271 Sulodexide
DB06779 Dalteparin
DB06822 Tinzaparin
DB06830 (1-HYDROXYHEPTANE-1,1-DIYL)BIS(PHOSPHONIC ACID)
DB06931 (1-HYDROXYNONANE-1,1-DIYL)BIS(PHOSPHONIC ACID)
DB06941 (Z)-2-[2-(4-methylpiperazin-1-yl)benzyl]diazenecarbothioamide
DB06953 2-CHLORO-5-(3-CHLORO-PHENYL)-6-[(4-CYANO-PHENYL)-(3-METHYL-3H-IMIDAZOL-4-YL)- METHOXYMETHYL]-NICOTINONITRILE
DB07004 2-[(5-hex-1-yn-1-ylfuran-2-yl)carbonyl]-N-methylhydrazinecarbothioamide
DB07216 (11S)-8-CHLORO-11-[1-(METHYLSULFONYL)PIPERIDIN-4-YL]-6-PIPERAZIN-1-YL-11H-BENZO[5,6]CYCLOHEPTA[1,2-B]PYRIDINE
DB07221 (2,2-DIPHOSPHONOETHYL)(DODECYL)DIMETHYLPHOSPHONIUM
DB07227 4-[(5-{[4-(3-CHLOROPHENYL)-3-OXOPIPERAZIN-1-YL]METHYL}-1H-IMIDAZOL-1-YL)METHYL]BENZONITRILE
DB07349 (1S)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PENTANOYLOXY)METHYL]ETHYL OCTANOATE
DB07392 2-CHLORO-4-ISOPROPYLAMINO-6-ETHYLAMINO -1,3,5-TRIAZINE
DB07404 (1-HYDROXY-1-PHOSPHONO-2-[1,1';3',1'']TERPHENYL-3-YL-ETHYL)-PHOSPHONIC ACID
DB07409 (1-HYDROXY-1-PHOSPHONO-2-[1,1';4',1'']TERPHENYL-3-YL-ETHYL)-PHOSPHONIC ACID
DB07410 [2-(3-DIBENZOFURAN-4-YL-PHENYL)-1-HYDROXY-1-PHOSPHONO-ETHYL]-PHOSPHONIC ACID
DB07426 [1-HYDROXY-2-(1,1':3',1''-TERPHENYL-3-YLOXY)ETHANE-1,1-DIYL]BIS(PHOSPHONIC ACID)
DB07551 2-CHLORO-4-ETHYLAMINO-6-(S(-)-2'-CYANO-4-BUTYLAMINO)-1,3,5-TRIAZINE
DB07552 2-CHLORO-4-ETHYLAMINO-6-(R(+)-2'-CYANO-4-BUTYLAMINO)-1,3,5-TRIAZINE
DB07667 2-((3',5'-DIMETHYL-4'-HYDROXYPHENYL)AZO)BENZOIC ACID
DB07752 FARNESYL
DB07771 [(3,7,11-TRIMETHYL-DODECA-2,6,10-TRIENYLOXYCARBAMOYL)-METHYL]-PHOSPHONIC ACID
DB07780 FARNESYL DIPHOSPHATE
DB07841 GERANYLGERANYL DIPHOSPHATE
DB07873 (1-HYDROXYDODECANE-1,1-DIYL)BIS(PHOSPHONIC ACID)
DB07880 2-((4'-HYDROXYPHENYL)-AZO)BENZOIC ACID
DB07895 ALPHA-HYDROXYFARNESYLPHOSPHONIC ACID
DB08180 2-[METHYL-(5-GERANYL-4-METHYL-PENT-3-ENYL)-AMINO]-ETHYL-DIPHOSPHATE
DB08181 2-((3'-METHYL-4'-HYDROXYPHENYL)AZO)BENZOIC ACID
DB08196 2-((3',5'-DIMETHOXY-4'-HYDROXYPHENYL)AZO)BENZOIC ACID
DB08215 2-T-BUTYLAMINO-4-ETHYLAMINO-6-METHYLTHIO-S-TRIAZINE
DB08216 2-((3'-TERTBUTYL-4'-HYDROXYPHENYL)AZO)BENZOIC ACID
DB08252 2-((4'-HYDROXYNAPHTHYL)-AZO)BENZOIC ACID
DB08529 (6E,11E)-HEPTADECA-6,11-DIENE-9,9-DIYLBIS(PHOSPHONIC ACID)
DB08596 5'-deoxy-5'-piperidin-1-ylthymidine
DB08661 1-(2,5-dideoxy-5-pyrrolidin-1-yl-beta-L-erythro-pentofuranosyl)-5-methylpyrimidine-2,4(1H,3H)-dione
DB08674 (20S)-19,20,21,22-TETRAHYDRO-19-OXO-5H-18,20-ETHANO-12,14-ETHENO-6,10-METHENO-18H-BENZ[D]IMIDAZO[4,3-K][1,6,9,12]OXATRIAZA-CYCLOOCTADECOSINE-9-CARBONITRILE
DB08676 (20S)-19,20,22,23-TETRAHYDRO-19-OXO-5H,21H-18,20-ETHANO-12,14-ETHENO-6,10-METHENOBENZ[D]IMIDAZO[4,3-L][1,6,9,13]OXATRIAZACYCLONOADECOSINE-9-CARBONITRILE
DB08689 UBIQUINONE-1
DB08690 UBIQUINONE-2
DB08813 Nadroparin
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