DT-Web: DB00753

Identification

Name

Isoflurane

Accession Number

DB00753 (APRD00212)

Type

small molecule

Description

A stable, non-explosive inhalation anesthetic, relatively free from significant side effects. [PubChem]

Structure

MOL SDF PDB SMILES InChI

Categories ^(*)

Molecular Weight

184.492

Groups

approved

Monoisotopic Weight

183.971433418

Pharmacology

Indication

For induction and maintenance of general anesthesia.

Mechanism of action

Isoflurane induces a reduction in junctional conductance by decreasing gap junction channel opening times and increasing gap junction channel closing times. Isoflurane also activates calcium dependent ATPase in the sarcoplasmic reticulum by increasing the fluidity of the lipid membrane. Also appears to bind the D subunit of ATP synthase and NADH dehydogenase. Isoflurane also binds to the GABA receptor, the large conductance Ca²⁺ activated potassium channel, the glutamate receptor and the glycine receptor.

Absorption

Not Available

Protein binding

Not Available

Biotransformation

Minimal

Route of elimination

Not Available

Toxicity

LC50=15300 ppm/3 hrs (inhalation by rat)

Affected organisms

Humans and other mammals

Interactions

Drug Interactions

Drug	Mechanism of interaction
Labetalol	Monitor arterial pressure closely

Food Interactions

Not Available

Gamma-aminobutyric-acid receptor subunit alpha-1
Name	Gamma-aminobutyric-acid receptor subunit alpha-1
Gene Name	GABRA1
Pharmacological action	yes
Actions	agonist
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed McCracken ML, Borghese CM, Trudell JR, Harris RA: A Transmembrane Amino Acid in the GABAA Receptor {beta}2 Subunit Critical for the Actions of Alcohols and Anesthetics. J Pharmacol Exp Ther. 2010 Sep 8. - Pubmed Seo K, Seino H, Yoshikawa H, Petrenko AB, Baba H, Fujiwara N, Someya G, Kawano Y, Maeda T, Matsuda M, Kanematsu T, Hirata M: Genetic reduction of GABA(A) receptor gamma2 subunit expression potentiates the immobilizing action of isoflurane. Neurosci Lett. 2010 Mar 12;472(1):1-4. Epub 2010 Jan 25. - Pubmed
DTHybrid score	0.5172
Calcium-transporting ATPase type 2C member 1
Name	Calcium-transporting ATPase type 2C member 1
Gene Name	ATP2C1
Pharmacological action	yes
Actions	inhibitor
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed Kosk-Kosicka D, Roszczynska G: Inhibition of plasma membrane Ca(2+)-ATPase activity by volatile anesthetics. Anesthesiology. 1993 Oct;79(4):774-80. - Pubmed
DTHybrid score	0.6553
Glycine receptor subunit alpha-1
Name	Glycine receptor subunit alpha-1
Gene Name	GLRA1
Pharmacological action	yes
Actions	agonist
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed Grasshoff C, Antkowiak B: Effects of isoflurane and enflurane on GABAA and glycine receptors contribute equally to depressant actions on spinal ventral horn neurones in rats. Br J Anaesth. 2006 Nov;97(5):687-94. Epub 2006 Sep 13. - Pubmed
DTHybrid score	0.6112
Glutamate receptor 1
Name	Glutamate receptor 1
Gene Name	GRIA1
Pharmacological action	yes
Actions	antagonist
References	Guo L, Wang Y: Glutamate stimulates glutamate receptor interacting protein 1 degradation by ubiquitin-proteasome system to regulate surface expression of GluR2. Neuroscience. 2007 Mar 2;145(1):100-9. Epub 2007 Jan 3. - Pubmed Dildy-Mayfield JE, Eger EI 2nd, Harris RA: Anesthetics produce subunit-selective actions on glutamate receptors. J Pharmacol Exp Ther. 1996 Mar;276(3):1058-65. - Pubmed
DTHybrid score	0.6501
Potassium voltage-gated channel subfamily A member 1
Name	Potassium voltage-gated channel subfamily A member 1
Gene Name	KCNA1
Pharmacological action	yes
Actions	inducer
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed Matchett GA, Allard MW, Martin RD, Zhang JH: Neuroprotective effect of volatile anesthetic agents: molecular mechanisms. Neurol Res. 2009 Mar;31(2):128-34. - Pubmed
DTHybrid score	0.5752
ATP synthase delta chain, mitochondrial
Name	ATP synthase delta chain, mitochondrial
Gene Name	ATP5D
Pharmacological action	unknown
Actions	unknown
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score	0.6144
Calmodulin
Name	Calmodulin
Gene Name	CALM1
Pharmacological action	unknown
Actions	other/unknown
References	Fan RS, Jacamo RO, Jiang X, Sinnett-Smith J, Rozengurt E: G protein-coupled receptor activation rapidly stimulates focal adhesion kinase phosphorylation at Ser-843. Mediation by Ca2+, calmodulin, and Ca2+/calmodulin-dependent kinase II. J Biol Chem. 2005 Jun 24;280(25):24212-20. Epub 2005 Apr 21. - Pubmed Bickler PE, Zhan X, Fahlman CS: Isoflurane preconditions hippocampal neurons against oxygen-glucose deprivation: role of intracellular Ca2+ and mitogen-activated protein kinase signaling. Anesthesiology. 2005 Sep;103(3):532-9. - Pubmed Sazonova OV, Blishchenko EY, Tolmazova AG, Khachin DP, Leontiev KV, Karelin AA, Ivanov VT: Stimulation of fibroblast proliferation by neokyotorphin requires Ca influx and activation of PKA, CaMK II and MAPK/ERK. FEBS J. 2007 Jan;274(2):474-84. - Pubmed
DTHybrid score	0.4685

Cytochrome P450 2E1
Name	Cytochrome P450 2E1
Gene Name	CYP2E1
Actions	substrate
References	Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.438
Cytochrome P450 2B6
Name	Cytochrome P450 2B6
Gene Name	CYP2B6
Actions	substrate,inhibitor,inducer
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.3791
NADH-ubiquinone oxidoreductase chain 1
Name	NADH-ubiquinone oxidoreductase chain 1
Gene Name	MT-ND1
Actions	inhibitor
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed Hanley PJ, Ray J, Brandt U, Daut J: Halothane, isoflurane and sevoflurane inhibit NADH:ubiquinone oxidoreductase (complex I) of cardiac mitochondria. J Physiol. 2002 Nov 1;544(Pt 3):687-93. - Pubmed
DTHybrid score	0.5555

Id	Partner name	Gene Name	Score
4512	Cytochrome P450 3A4	CYP3A4	0.2975
4757	Cytochrome P450 2C9	CYP2C9	0.2064
4119	Cytochrome P450 2D6	CYP2D6	0.1877
4200	Cytochrome P450 1A2	CYP1A2	0.1692
5718	Cytochrome P450 2A6	CYP2A6	0.1689
6016	Cytochrome P450 2C19	CYP2C19	0.1358
610	Calcium-activated potassium channel subunit alpha 1	KCNMA1	0.1213
1588	Multidrug resistance protein 1	ABCB1	0.1085
4924	Cytochrome P450 2C8	CYP2C8	0.1082
4118	Cytochrome P450 3A5	CYP3A5	0.1014
523	Gamma-aminobutyric-acid receptor subunit alpha-5	GABRA5	0.0824
423	Gamma-aminobutyric-acid receptor subunit alpha-2	GABRA2	0.0818
580	Gamma-aminobutyric-acid receptor subunit alpha-3	GABRA3	0.0773
1561	Troponin C, slow skeletal and cardiac muscles	TNNC1	0.067
6024	Cytochrome P450 1A1	CYP1A1	0.0647
1089	Cartilage oligomeric matrix protein	COMP	0.0616
1108	Calpastatin	CAST	0.0616
530	Gamma-aminobutyric-acid receptor subunit alpha-4	GABRA4	0.0589
841	Gamma-aminobutyric-acid receptor subunit alpha-6	GABRA6	0.0577
6107	Cytochrome P450 3A7	CYP3A7	0.0549
6086	Gamma-aminobutyric acid receptor subunit gamma-2	GABRG2	0.0533
6098	Potassium voltage-gated channel subfamily D member 2	KCND2	0.0515
6099	Potassium voltage-gated channel subfamily D member 3	KCND3	0.0515
4098	Gamma-aminobutyric-acid receptor subunit beta-1	GABRB1	0.0513
1181	Alpha-1-acid glycoprotein 1	ORM1	0.0513
4100	Gamma-aminobutyric-acid receptor subunit beta-2	GABRB2	0.0509
820	Glycine receptor subunit alpha-2	GLRA2	0.0509
1768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit	GNG2	0.0491
1581	G protein-activated inward rectifier potassium channel 2	KCNJ6	0.049
1571	G protein-activated inward rectifier potassium channel 1	KCNJ3	0.049
1268	Neuropeptide S receptor	NPSR1	0.049
706	Glutamate [NMDA] receptor subunit 3A	GRIN3A	0.0487
220	Sodium channel protein type 5 subunit alpha	SCN5A	0.0453
20	Prostaglandin G/H synthase 1	PTGS1	0.0442
478	Voltage-dependent L-type calcium channel subunit alpha-1C	CACNA1C	0.0433
6048	Troponin C, skeletal muscle	TNNC2	0.0433
837	Glutamate [NMDA] receptor subunit epsilon-1	GRIN2A	0.0394
591	Glutamate [NMDA] receptor subunit 3B	GRIN3B	0.039
6073	Potassium channel subfamily K member 9	KCNK9	0.0382
6072	Potassium channel subfamily K member 3	KCNK3	0.0381
918	Glutamate receptor, ionotropic kainate 2	GRIK2	0.0378
4095	Neuronal acetylcholine receptor subunit alpha-7	CHRNA7	0.0375
947	Neuronal acetylcholine receptor subunit alpha-4	CHRNA4	0.0375
461	Glycine receptor subunit alpha-3	GLRA3	0.0372
2132	Protein S100-B	S100B	0.037
921	Glutamate receptor 2	GRIA2	0.0367
1507	Cytochrome c	CYCS	0.0359
831	D(2) dopamine receptor	DRD2	0.0358
462	Intermediate conductance calcium-activated potassium channel protein 4	KCNN4	0.0357
4099	Gamma-aminobutyric-acid receptor subunit beta-3	GABRB3	0.0353
5469	Head decoration protein	shp	0.035
722	Troponin I, cardiac muscle	TNNI3	0.0347
62	Glycine receptor subunit beta	GLRB	0.0341
556	Alpha-1A adrenergic receptor	ADRA1A	0.034
6087	Gamma-aminobutyric acid receptor subunit gamma-1	GABRG1	0.0338
6093	Gamma-aminobutyric acid receptor subunit delta	GABRD	0.0336
6089	Gamma-aminobutyric acid receptor subunit epsilon	GABRE	0.0336
142	Gamma-aminobutyric-acid receptor subunit rho-1	GABRR1	0.0334
540	Sodium-dependent noradrenaline transporter	SLC6A2	0.0316
6088	Gamma-aminobutyric acid receptor subunit gamma-3	GABRG3	0.0302
6090	Gamma-aminobutyric acid receptor subunit pi	GABRP	0.0302
6092	Gamma-aminobutyric acid receptor subunit rho-2	GABRR2	0.0301
6115	Gamma-aminobutyric acid receptor subunit rho-3	GABRR3	0.0301
1729	Solute carrier family 22 member 6	SLC22A6	0.03
401	Glutamate [NMDA] receptor subunit zeta-1	GRIN1	0.0299
492	Histamine H1 receptor	HRH1	0.0288
6106	Cytochrome P450 2C18	CYP2C18	0.0282
1735	Canalicular multispecific organic anion transporter 1	ABCC2	0.0276
2207	Rhodopsin	RHO	0.0268
1732	ATP-binding cassette sub-family G member 2	ABCG2	0.0268
811	Translocator protein	TSPO	0.0267
290	Prostaglandin G/H synthase 2	PTGS2	0.0263
23	D(1A) dopamine receptor	DRD1	0.0259
502	5-hydroxytryptamine 2A receptor	HTR2A	0.0258
891	Dihydropteroate synthase	folP	0.0258
5359	Dihydropteroate synthase	folP	0.0258
7175	Dihydropteroate synthase	sulI	0.0258
3811	Cytochrome P450 19A1	CYP19A1	0.0256
964	Voltage-dependent T-type calcium channel subunit alpha-1H	CACNA1H	0.0253
471	Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+)	SLC6A14	0.025
6139	Solute carrier organic anion transporter family member 1A2	SLCO1A2	0.0249
824	Sodium-dependent serotonin transporter	SLC6A4	0.0237
468	Cytochrome P450 4A11	CYP4A11	0.0227
6151	Monocarboxylate transporter 10	SLC16A10	0.0217
6091	Gamma-aminobutyric acid receptor subunit theta	GABRQ	0.0208
6145	Solute carrier family 22 member 1	SLC22A1	0.0207
1490	Solute carrier organic anion transporter family member 1B1	SLCO1B1	0.0205
4115	Voltage-dependent L-type calcium channel subunit alpha-1D	CACNA1D	0.0204
2981	Phospholipase A2, membrane associated	PLA2G2A	0.0199
6142	Solute carrier family 22 member 8	SLC22A8	0.0198
103	Muscarinic acetylcholine receptor M1	CHRM1	0.0196
318	Alpha-2A adrenergic receptor	ADRA2A	0.0193
1709	Canalicular multispecific organic anion transporter 2	ABCC3	0.0193
862	Multidrug resistance-associated protein 1	ABCC1	0.0191
198	Sodium channel protein type 10 subunit alpha	SCN10A	0.019
3923	Cholinesterase	BCHE	0.0185
51	Muscarinic acetylcholine receptor M3	CHRM3	0.0183
4110	Voltage-dependent L-type calcium channel subunit beta-2	CACNB2	0.0183
274	Muscarinic acetylcholine receptor M5	CHRM5	0.018
6022	UDP-glucuronosyltransferase 1-1	UGT1A1	0.0176
762	Voltage-dependent calcium channel subunit alpha-2/delta-1	CACNA2D1	0.0176
450	Muscarinic acetylcholine receptor M4	CHRM4	0.0175
617	Muscarinic acetylcholine receptor M2	CHRM2	0.0171
1389	Transforming growth factor beta-1	TGFB1	0.0169
4111	Voltage-dependent L-type calcium channel subunit alpha-1S	CACNA1S	0.0169
1898	Cytochrome P450 1B1	CYP1B1	0.0165
251	Alcohol dehydrogenase 1A	ADH1A	0.0164
6017	Cholesterol side-chain cleavage enzyme, mitochondrial	CYP11A1	0.0164
444	Alcohol dehydrogenase 1B	ADH1B	0.0152
240	Gamma-aminobutyric acid type B receptor, subunit 1	GABBR1	0.0151
6047	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	PDE1A	0.0148
2392	Biphenyl-2,3-diol 1,2-dioxygenase	bphC	0.0146
3032	Biphenyl-2,3-diol 1,2-dioxygenase	bphC	0.0146
6178	UDP-glucuronosyltransferase 2B7	UGT2B7	0.0144
5692	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	PDE1B	0.0143
2164	Multidrug resistance-associated protein 4	ABCC4	0.0143
6541	Peptostreptococcal albumin-binding protein	pab	0.0142
392	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	CACNA1A	0.014
1024	Solute carrier family 22 member 11	SLC22A11	0.0139
6018	UDP-glucuronosyltransferase 1-9	UGT1A9	0.0139
6144	Solute carrier family 22 member 2	SLC22A2	0.0137
535	Voltage-dependent T-type calcium channel subunit alpha-1G	CACNA1G	0.0134
136	Estrogen receptor	ESR1	0.0134
158	Sodium channel protein type 1 subunit alpha	SCN1A	0.0133
260	Cytochrome P450 51	ERG11	0.0133
761	Cytochrome P450 51	ERG11	0.0133
3163	Cytochrome P450 51	cyp51	0.0133
5682	Ribonuclease pancreatic	RNASE1	0.0131
696	Kappa-type opioid receptor	OPRK1	0.0131
6147	Solute carrier family 22 member 3	SLC22A3	0.0128
3426	Glutamine synthetase	glnA	0.0125
3987	Glutamine synthetase	GLUL	0.0125
517	Alcohol dehydrogenase 1C	ADH1C	0.0125
2314	Triosephosphate isomerase	TPI	0.0123
3417	Triosephosphate isomerase	tpiA	0.0123
3443	Triosephosphate isomerase	tpiA	0.0123
6346	Triosephosphate isomerase	TPI1	0.0123
442	Envelope glycoprotein	gp41	0.012
4859	Envelope glycoprotein	env	0.012
467	Delta-type opioid receptor	OPRD1	0.012
15	Voltage-dependent T-type calcium channel subunit alpha-1I	CACNA1I	0.0119
320	5-hydroxytryptamine 1A receptor	HTR1A	0.0118
847	Mu-type opioid receptor	OPRM1	0.0118
2795	Methionine aminopeptidase 2	METAP2	0.0117
6143	Solute carrier family 22 member 7	SLC22A7	0.0113
805	Cytochrome P450 11B1, mitochondrial	CYP11B1	0.0112
776	Bile salt export pump	ABCB11	0.0111
6157	Solute carrier organic anion transporter family member 1B3	SLCO1B3	0.0108
101	Potassium voltage-gated channel subfamily H member 2	KCNH2	0.0106
632	Alpha-1B adrenergic receptor	ADRA1B	0.0106
6025	UDP-glucuronosyltransferase 1-4	UGT1A4	0.0104
789	Alpha-1D adrenergic receptor	ADRA1D	0.0104
147	Aldehyde dehydrogenase, mitochondrial	ALDH2	0.0103
122	P2Y purinoceptor 12	P2RY12	0.0101
2211	Fatty acid-binding protein, heart	FABP3	0.0098
118	Organic cation/carnitine transporter 2	SLC22A5	0.0097
566	Serotransferrin	TF	0.0094
3947	Xanthine dehydrogenase/oxidase	XDH	0.0094
6859	Protein S100-A4	S100A4	0.0094
464	Glutamate [NMDA] receptor subunit epsilon-2	GRIN2B	0.0094
1539	Oligopeptide transporter, small intestine isoform	SLC15A1	0.0093
629	Alpha-2B adrenergic receptor	ADRA2B	0.0093
713	Sodium-dependent dopamine transporter	SLC6A3	0.0092
6176	UDP-glucuronosyltransferase 1-3	UGT1A3	0.0091
806	Sodium/potassium-transporting ATPase alpha-1 chain	ATP1A1	0.0091
4604	Liver carboxylesterase 1	CES1	0.0091
439	Glutamate [NMDA] receptor subunit epsilon-4	GRIN2D	0.0089
505	Glutamate [NMDA] receptor subunit epsilon-3	GRIN2C	0.0089
4160	Voltage-dependent calcium channel subunit alpha-2/delta-2	CACNA2D2	0.0087
6100	BDNF/NT-3 growth factors receptor	NTRK2	0.0085
756	Sex hormone-binding globulin	SHBG	0.0083
1618	High affinity nerve growth factor receptor	NTRK1	0.0083
1086	Potassium voltage-gated channel subfamily KQT member 2	KCNQ2	0.0082
174	Sigma 1-type opioid receptor	SIGMAR1	0.0082
1262	Corticotropin-lipotropin	POMC	0.0081
1632	Solute carrier organic anion transporter family member 2B1	SLCO2B1	0.008
638	D(3) dopamine receptor	DRD3	0.008
3941	Amine oxidase [flavin-containing] A	MAOA	0.008
6525	Group IID secretory phospholipase A2	PLA2G2D	0.008
590	5-hydroxytryptamine 2C receptor	HTR2C	0.008
1974	Oligopeptide transporter, kidney isoform	SLC15A2	0.0077
6085	Fatty acid-binding protein, intestinal	FABP2	0.0077
172	Potassium channel subfamily K member 1	KCNK1	0.0077
734	D1 dopamine receptor-interacting protein calcyon	CALY	0.0077
6102	Arylamine N-acetyltransferase 2	NAT2	0.0077
6031	Cytochrome P450 3A43	CYP3A43	0.0076
6020	Aldehyde oxidase	AOX1	0.0075
382	Glutamate receptor, ionotropic kainate 1	GRIK1	0.0075
781	ATP-sensitive inward rectifier potassium channel 11	KCNJ11	0.0075
1757	Myeloperoxidase	MPO	0.0073
543	Penicillin-binding protein 1B	mrcB	0.0072
6186	Penicillin-binding protein 1B	ponB	0.0072
6822	Penicillin-binding protein 1b	pbp1b	0.0072
6844	Penicillin-binding protein 1b	pbp1b	0.0072
787	Vitamin K epoxide reductase complex subunit 1	VKORC1	0.0072
1	Peptidoglycan synthetase ftsI	ftsI	0.0071
4155	Peptidoglycan synthetase ftsI	ftsI	0.0071
645	Penicillin-binding protein 1A	mrcA	0.0071
5805	Penicillin-binding protein 1A	ponA	0.0071
6185	Penicillin-binding protein 1A	mrcA	0.0071
6799	Penicillin-binding protein 1A	pbpA	0.0071
6181	UDP-glucuronosyltransferase 1-8	UGT1A8	0.007
16	Adenosine A1 receptor	ADORA1	0.007
378	Alpha-2C adrenergic receptor	ADRA2C	0.007
741	Potassium voltage-gated channel subfamily KQT member 1	KCNQ1	0.007
4209	ATP-sensitive inward rectifier potassium channel 8	KCNJ8	0.0069
6158	Solute carrier organic anion transporter family member 1C1	SLCO1C1	0.0068
1995	Sodium channel protein type 9 subunit alpha	SCN9A	0.0068
3932	Glutathione S-transferase A2	GSTA2	0.0068
341	5-hydroxytryptamine 3 receptor	HTR3A	0.0068
731	HIV-1 protease	HIV-1 protease	0.0067
2178	Metabotropic glutamate receptor 5	GRM5	0.0067
36	Insulin receptor	INSR	0.0066
6101	Dimethylaniline monooxygenase [N-oxide-forming] 3	FMO3	0.0065
6023	Cytochrome P450 11B2, mitochondrial	CYP11B2	0.0064
738	Monocarboxylate transporter 1	SLC16A1	0.0063
1119	Peroxiredoxin-5, mitochondrial	PRDX5	0.0063
230	ATP-binding cassette transporter sub-family C member 8	ABCC8	0.0063
4199	Sphingosine 1-phosphate receptor Edg-8	S1PR5	0.0063
183	Vascular endothelial growth factor A	VEGFA	0.0062
1010	Cytochrome P450 51A1	CYP51A1	0.0062
6141	Sodium/bile acid cotransporter	SLC10A1	0.0061
373	Transthyretin	TTR	0.0061
631	3-hydroxy-3-methylglutaryl-coenzyme A reductase	HMGCR	0.0061
3387	3-hydroxy-3-methylglutaryl-coenzyme A reductase	mvaA	0.0061
6136	Multidrug resistance-associated protein 5	ABCC5	0.006
146	Androgen receptor	AR	0.0059
3939	Amine oxidase [flavin-containing] B	MAOB	0.0059
6220	Aryl hydrocarbon receptor	AHR	0.0059
833	Organic cation/carnitine transporter 1	SLC22A4	0.0058
411	Glycine N-methyltransferase	GNMT	0.0058
6104	Dimethylaniline monooxygenase [N-oxide-forming] 1	FMO1	0.0058
3937	Fatty-acid amide hydrolase	FAAH	0.0057
869	Estrogen receptor beta	ESR2	0.0057
613	Atrial natriuretic peptide receptor A	NPR1	0.0056
3175	Glutamate--cysteine ligase	gshA	0.0056
766	Beta-2 adrenergic receptor	ADRB2	0.0056
6177	UDP-glucuronosyltransferase 1-10	UGT1A10	0.0056
6270	Group IIE secretory phospholipase A2	PLA2G2E	0.0055
2038	Inhibitor of nuclear factor kappa-B kinase subunit beta	IKBKB	0.0054
3830	Calreticulin	CALR	0.0053
2853	14 kDa fatty acid-binding protein	Not Available	0.0053
844	Epidermal growth factor receptor	EGFR	0.0052
6589	Delta-hemolysin	hld	0.0051
6424	Light-harvesting protein B-800/820 beta chain	Not Available	0.0051
6586	Protein S100-G	S100G	0.0051
6591	ATP synthase C chain	atpH	0.0051
6587	Rubredoxin	rub	0.0051
6423	Light-harvesting protein B-800/820 alpha chain	Not Available	0.0051
6588	Methionyl-tRNA formyltransferase	fmt	0.005
6585	HLA class I histocompatibility antigen, B-27 alpha chain	HLA-B	0.005
4718	Putative ATP-dependent Clp protease proteolytic subunit, mitochondrial	CLPP	0.005
6593	Immunoglobulin G-binding protein G	spg	0.005
6592	Probable L-ascorbate-6-phosphate lactonase ulaG	ulaG	0.005
6150	Solute carrier organic anion transporter family member 4C1	SLCO4C1	0.005
4120	NADPH--cytochrome P450 reductase	POR	0.005
6035	Nuclear receptor ROR-beta	RORB	0.005
6034	Hydroxyindole O-methyltransferase	ASMT	0.005
6036	Eosinophil peroxidase	EPX	0.005
592	Carbonic anhydrase 4	CA4	0.005
238	Peroxisome proliferator-activated receptor gamma	PPARG	0.005
6027	Alkaline phosphatase, tissue-nonspecific isozyme	ALPL	0.005
1680	Solute carrier family 2, facilitated glucose transporter member 1	SLC2A1	0.0049
6152	Solute carrier organic anion transporter family member 2A1	SLCO2A1	0.0049
4059	Glycine N-acyltransferase-like protein 1	GLYATL1	0.0049
4056	N-arachidonyl glycine receptor	GPR18	0.0049
4060	Vesicular inhibitory amino acid transporter	SLC32A1	0.0049
4061	Peroxisomal sarcosine oxidase	PIPOX	0.0049
4055	Bile acid CoA:amino acid N-acyltransferase	BAAT	0.0049
4058	Glycine N-acyltransferase-like protein 2	GLYATL2	0.0049
4057	Glycine N-acyltransferase	GLYAT	0.0049
1088	5-aminolevulinate synthase, erythroid-specific, mitochondrial	ALAS2	0.0049
1236	Sodium- and chloride-dependent glycine transporter 1	SLC6A9	0.0049
1466	Glycyl-tRNA synthetase	GARS	0.0049
4062	Sodium- and chloride-dependent glycine transporter 2	SLC6A5	0.0049
243	Ribosyldihydronicotinamide dehydrogenase [quinone]	NQO2	0.0049
1178	Adenosine A2a receptor	ADORA2A	0.0048
2184	Cystic fibrosis transmembrane conductance regulator	CFTR	0.0048
6184	D-alanyl-D-alanine carboxypeptidase dacC	dacC	0.0048
6040	6-phosphogluconate dehydrogenase, decarboxylating	PGD	0.0048
1656	CYP2B protein	CYP2B	0.0047
2230	Catalase	CAT	0.0047
3249	Catalase	katA	0.0047
3625	Catalase	katA	0.0047
4539	Catalase	katA	0.0047
4941	Catalase	katB	0.0047
2183	Fatty acid-binding protein, adipocyte	FABP4	0.0047
3382	Glycolipid transfer protein	GLTP	0.0046
357	Carbonic anhydrase 2	CA2	0.0046
6180	UDP-glucuronosyltransferase 2B4	UGT2B4	0.0045
830	Glutamate dehydrogenase 2, mitochondrial	GLUD2	0.0045
790	DNA polymerase subunit alpha B	POLA2	0.0045
115	Penicillin-binding protein 2	mrdA	0.0044
6069	Penicillin-binding protein 2	mrdA	0.0044
6118	Penicillin-binding protein 2	penA	0.0044
6187	Penicillin-binding protein 2	pbpA	0.0044
6686	Penicillin-binding protein 2	pbp2	0.0044
6939	Penicillin-binding protein 2	mrdA	0.0044
7163	Penicillin-binding protein 2	pbpA	0.0044
6499	Cytochrome c oxidase polypeptide 7A1, mitochondrial	COX7A1	0.0044
6319	Respiratory nitrate reductase 1 gamma chain	narI	0.0044
6495	Cytochrome c oxidase subunit 7C, mitochondrial	COX7C	0.0044
6279	Beta-2-microglobulin	B2M	0.0044
6496	Cytochrome c oxidase subunit 8A, mitochondrial	COX8A	0.0044
6493	Cytochrome c oxidase subunit 6C	COX6C	0.0044
6318	Respiratory nitrate reductase 1 beta chain	narH	0.0044
6494	Cytochrome c oxidase subunit 7B, mitochondrial	COX7B	0.0044
6491	Cytochrome c oxidase subunit 5A, mitochondrial	COX5A	0.0044
6498	Cytochrome c oxidase subunit 6B1	COX6B1	0.0044
6497	Cytochrome c oxidase subunit 6A2, mitochondrial	COX6A2	0.0044
6317	Respiratory nitrate reductase 1 alpha chain	narG	0.0044
5793	Cytochrome c oxidase subunit 2	MT-CO2	0.0044
6559	Cytochrome c oxidase subunit 2	ctaC	0.0044
6669	Cytochrome c oxidase subunit 2	ctaC	0.0044
6490	Cytochrome c oxidase subunit 3	MT-CO3	0.0044
6489	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	COX4I1	0.0044
371	Cytochrome c oxidase subunit 1	MT-CO1	0.0044
6558	Cytochrome c oxidase subunit 1	ctaD	0.0044
765	Indoleamine 2,3-dioxygenase	IDO1	0.0044
3804	Sodium channel protein type 4 subunit alpha	SCN4A	0.0044
94	5-hydroxytryptamine 4 receptor	HTR4	0.0044
5645	DNA topoisomerase 4 subunit B	parE	0.0044
6227	DNA topoisomerase 4 subunit B	parE	0.0044
887	DNA gyrase subunit B	gyrB	0.0044
4150	DNA gyrase subunit B	gyrB	0.0044
6225	DNA gyrase subunit B	gyrB	0.0044
6014	Cytochrome P450 2A13	CYP2A13	0.0042
362	Melatonin receptor type 1B	MTNR1B	0.0042
571	Melatonin receptor type 1A	MTNR1A	0.0042
17	Proto-oncogene tyrosine-protein kinase ABL1	ABL1	0.0042
1284	Nuclear receptor subfamily 1 group I member 2	NR1I2	0.0042
6137	Multidrug resistance-associated protein 6	ABCC6	0.0041
575	2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial	GCAT	0.0041
455	5-aminolevulinate synthase, nonspecific, mitochondrial	ALAS1	0.0041
681	Glycine dehydrogenase [decarboxylating], mitochondrial	GLDC	0.0041
777	Tumor necrosis factor	TNF	0.0041
6428	Light-harvesting protein B-800/850 beta chain	Not Available	0.0041
6427	Light-harvesting protein B-800/850 alpha chain	Not Available	0.0041
6533	Light-harvesting protein B-800/850 alpha chain	A1	0.0041
404	DNA gyrase subunit A	gyrA	0.004
6224	DNA gyrase subunit A	gyrA	0.004
477	DNA topoisomerase 4 subunit A	parC	0.004
886	DNA topoisomerase 4 subunit A	parC	0.004
6226	DNA topoisomerase 4 subunit A	parC	0.004
558	Solute carrier family 12 member 1	SLC12A1	0.004
6508	Putative uncharacterized protein	srtB	0.004
6543	Putative uncharacterized protein	tcp14	0.004
6615	Putative uncharacterized protein	MT0785	0.004
6623	Putative uncharacterized protein	Not Available	0.004
6806	Putative uncharacterized protein	AGR_C_2535	0.004
6813	Putative uncharacterized protein	SAV4671	0.004
6815	Putative uncharacterized protein	AFE_1514	0.004
6819	Putative uncharacterized protein	RUMGNA_03254	0.004
6825	Putative uncharacterized protein	CV_3270	0.004
541	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	PDE4B	0.004
65	Matrix metalloproteinase-9	Not Available	0.004
4161	Furin	FURIN	0.004
309	Antithrombin-III	SERPINC1	0.004
80	Peroxisome proliferator-activated receptor alpha	PPARA	0.004
380	Cytochrome P450 17A1	CYP17A1	0.0039
3823	Cytokine receptor common gamma chain	IL2RG	0.0039
4054	Glycine cleavage system H protein, mitochondrial	GCSH	0.0039
201	Glutamate dehydrogenase 1, mitochondrial	GLUD1	0.0039
922	Glutamate receptor 4	GRIA4	0.0039
6576	Geranylgeranyl transferase type-2 subunit beta	RABGGTB	0.0038
6067	Penicillin binding protein 2a	mecA	0.0038
6575	Geranylgeranyl transferase type-2 subunit alpha	RABGGTA	0.0038
200	Carnitine O-palmitoyltransferase 2, mitochondrial	CPT2	0.0038
451	Carnitine O-palmitoyltransferase I, liver isoform	CPT1A	0.0038
3904	Alanine aminotransferase 2	GPT2	0.0038
735	Alanine aminotransferase 1	GPT	0.0038
563	Thyroid peroxidase	TPO	0.0038
6138	Multidrug resistance protein 3	ABCB4	0.0038
280	4-aminobutyrate aminotransferase, mitochondrial	ABAT	0.0038
4210	Toll-like receptor 4	TLR4	0.0038
6068	Guanylate cyclase soluble subunit alpha-2	GUCY1A2	0.0038
4113	Voltage-dependent L-type calcium channel subunit alpha-1F	CACNA1F	0.0037
139	Aldo-keto reductase family 1 member C1	AKR1C1	0.0037
448	Vitamin K-dependent gamma-carboxylase	GGCX	0.0037
6079	Neuronal acetylcholine receptor subunit alpha-3	CHRNA3	0.0037
3884	SHMT2 protein	SHMT2	0.0037
3901	SHMT2 protein	SHMT2	0.0037
3885	Hypothetical protein DKFZp686P09201	DKFZp686P09201	0.0037
3879	Serine hydroxymethyltransferase 2	Not Available	0.0037
321	Serine hydroxymethyltransferase, mitochondrial	SHMT2	0.0037
1638	Solute carrier family 2, facilitated glucose transporter member 2	SLC2A2	0.0037
6432	Transporter	snf	0.0037
207	Glutathione synthetase	GSS	0.0036
5269	Glutathione synthetase	gshB	0.0036
70	Type-1 angiotensin II receptor	AGTR1	0.0036
83	Alpha-aminoadipic semialdehyde synthase, mitochondrial	AASS	0.0036
924	Glutamate receptor, ionotropic kainate 3	GRIK3	0.0036
920	Glutamate receptor, ionotropic kainate 5	GRIK5	0.0036
919	Glutamate receptor, ionotropic kainate 4	GRIK4	0.0036
114	Alanine--glyoxylate aminotransferase 2, mitochondrial	AGXT2	0.0036
4027	Glutamate receptor delta-1 subunit	GRID1	0.0036
4018	Glutamate receptor delta-2 subunit	GRID2	0.0036
4024	Mitochondrial glutamate carrier 2	SLC25A18	0.0036
4025	Mitochondrial glutamate carrier 1	SLC25A22	0.0036
819	Penicillin-binding protein 4	dacB	0.0036
664	Glutamate decarboxylase 2	GAD2	0.0036
3890	Glutamate decarboxylase 2	GAD2	0.0036
4022	Glutamate--ammonia ligase domain-containing protein 1	LGSN	0.0036
4021	Probable glutamyl-tRNA synthetase, mitochondrial	EARS2	0.0036
4023	N-acetylglutamate synthase, mitochondrial	NAGS	0.0036
1912	Excitatory amino acid transporter 1	SLC1A3	0.0036
4016	Excitatory amino acid transporter 5	SLC1A7	0.0036
4019	Excitatory amino acid transporter 4	SLC1A6	0.0036
1047	Excitatory amino acid transporter 2	SLC1A2	0.0036
927	Metabotropic glutamate receptor 8	GRM8	0.0036
925	Metabotropic glutamate receptor 4	GRM4	0.0036
926	Metabotropic glutamate receptor 7	GRM7	0.0036
4020	Glutamyl aminopeptidase	ENPEP	0.0036
915	Delta 1-pyrroline-5-carboxylate synthetase	ALDH18A1	0.0036
4026	Aspartyl aminopeptidase	DNPEP	0.0036
4017	5-oxoprolinase	OPLAH	0.0036
504	Mast/stem cell growth factor receptor	KIT	0.0035
473	L-lactate dehydrogenase A chain	LDHA	0.0035
904	Glutathione S-transferase P	GSTP1	0.0035
5432	Trafficking protein particle complex subunit 3	TRAPPC3	0.0035
724	Interleukin-2 receptor alpha chain	IL2RA	0.0034
717	Interleukin-2 receptor subunit beta	IL2RB	0.0034
383	Glycine amidinotransferase, mitochondrial	GATM	0.0034
5878	Alpha-7 nicotinic cholinergic receptor subunit	CHRFAM7A	0.0034
698	B-Raf proto-oncogene serine/threonine-protein kinase	BRAF	0.0034
1992	Vitamin D-binding protein	GC	0.0034
6352	Reaction center protein H chain	puhA	0.0033
6456	Reaction center protein H chain	puhA	0.0033
6682	Reaction center protein H chain	puhA	0.0033
6353	Reaction center protein L chain	pufL	0.0033
6454	Reaction center protein L chain	pufL	0.0033
6683	Reaction center protein L chain	pufL	0.0033
6354	Reaction center protein M chain	pufM	0.0033
6455	Reaction center protein M chain	pufM	0.0033
6684	Reaction center protein M chain	pufM	0.0033
6351	Photosynthetic reaction center cytochrome c subunit	pufC	0.0033
4116	Dihydropteroate synthetase	Not Available	0.0033
6148	Multidrug resistance-associated protein 7	ABCC10	0.0033
4122	Histone deacetylase 2	HDAC2	0.0033
33	Cystine/glutamate transporter	SLC7A11	0.0033
349	Serine--pyruvate aminotransferase	AGXT	0.0033
768	FK506-binding protein 1A	FKBP1A	0.0033
593	Proton-coupled amino acid transporter 1	SLC36A1	0.0032
686	Aldo-keto reductase family 1 member C2	AKR1C2	0.0032
594	Thyroxine-binding globulin	SERPINA7	0.0032
818	50S ribosomal protein L10	rplJ	0.0032
6677	Myelin P2 protein	PMP2	0.0032
3917	Methylenetetrahydrofolate reductase	MTHFR	0.0032
367	Serine hydroxymethyltransferase, cytosolic	SHMT1	0.0032
595	Fibrinogen alpha chain	FGA	0.0032
6766	O-GlcNAcase BT_4395	BT_4395	0.0031
3090	Chitosanase	csn	0.0031
4149	Nuclear factor NF-kappa-B p100 subunit	NFKB2	0.0031
773	Folylpolyglutamate synthase, mitochondrial	FPGS	0.0031
3760	Penicillin-binding protein 5 precursor	dacA	0.0031
668	Glutamate--cysteine ligase regulatory subunit	GCLM	0.003
5	Glutaminase liver isoform, mitochondrial	GLS2	0.003
917	Glutaminase kidney isoform, mitochondrial	GLS	0.003
3984	Probable glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial	PET112L	0.003
355	GMP synthase [glutamine-hydrolyzing]	GMPS	0.003
4353	GMP synthase [glutamine-hydrolyzing]	guaA	0.003
3991	Glutamine-dependent NAD(+) synthetase	NADSYN1	0.003
3982	Phosphoribosylformylglycinamidine synthase	PFAS	0.003
5261	Phosphoribosylformylglycinamidine synthase	purL	0.003
6153	Solute carrier organic anion transporter family member 4A1	SLCO4A1	0.003
758	Thyroid hormone receptor alpha	THRA	0.003
459	Retinoic acid receptor RXR-alpha	RXRA	0.003
3895	Kynurenine--oxoglutarate transaminase 3	CCBL2	0.003
665	Phosphoserine aminotransferase	PSAT1	0.003
4652	Phosphoserine aminotransferase	serC	0.003
801	Kynurenine/alpha-aminoadipate aminotransferase mitochondrial	AADAT	0.003
420	Glutamate decarboxylase 1	GAD1	0.003
3900	Glutamate decarboxylase 1	GAD1	0.003
923	Glutamate receptor 3	GRIA3	0.003
716	5-hydroxytryptamine 7 receptor	HTR7	0.003
6155	ATP-binding cassette transporter sub-family C member 11	ABCC11	0.003
1050	Bile salt sulfotransferase	SULT2A1	0.003
3027	Streptavidin	Not Available	0.0029
3813	Fibrinogen gamma chain	FGG	0.0029
3812	Fibrinogen beta chain [Contains: Fibrinopeptide B]	FGB	0.0029
625	Glutamate carboxypeptidase 2	FOLH1	0.0029
817	DNA topoisomerase 2-alpha	TOP2A	0.0029
485	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	PDE3A	0.0029
29	Tubulin beta-1 chain	TUBB1	0.0029
153	Dopamine beta-hydroxylase	DBH	0.0029
885	5-hydroxytryptamine 1B receptor	HTR1B	0.0029
161	Tubulin beta chain	TUBB	0.0029
312	Tubulin beta chain	TUB2	0.0029
1253	Interferon gamma	IFNG	0.0028
330	Spermidine synthase	SRM	0.0028
3038	Spermidine synthase	speE	0.0028
390	Adenosine A3 receptor	ADORA3	0.0028
1278	Pro-epidermal growth factor	EGF	0.0028
1671	Excitatory amino acid transporter 3	SLC1A1	0.0028
3810	Catechol O-methyltransferase	COMT	0.0028
186	Glutamate--cysteine ligase catalytic subunit	GCLC	0.0027
319	Opioid receptor, sigma 1	OPRS1	0.0027
3877	Growth-inhibiting protein 18	GIG18	0.0027
916	Metabotropic glutamate receptor 1	GRM1	0.0027
364	Corticosteroid 11-beta-dehydrogenase isozyme 1	HSD11B1	0.0027
394	Calcineurin subunit B isoform 1	PPP3R1	0.0027
6742	Recoverin	RCVRN	0.0027
6752	Guanylyl cyclase-activating protein 1	GUCA1A	0.0027
2528	Fatty acid metabolism regulator protein	fadR	0.0027
6740	Fatty acid metabolism regulator protein	fadR	0.0027
6753	Apolipoprotein M	APOM	0.0027
6743	Non-fluorescent flavoprotein	luxF	0.0027
6747	Chalcone/stilbene synthase family protein	MT1417	0.0027
6741	Peroxisomal 3,2-trans-enoyl-CoA isomerase	PECI	0.0027
6751	Gag polyprotein	gag	0.0027
6746	Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	PPP3CA	0.0027
6522	Hepatocyte nuclear factor 4-alpha	HNF4A	0.0027
6749	Polyprotein	Not Available	0.0027
3404	Exotoxin A	eta	0.0027
346	Thyroid hormone receptor beta-1	THRB	0.0027
737	Mineralocorticoid receptor	NR3C2	0.0027
5934	Cytochrome P450 26A1	CYP26A1	0.0027
6045	Voltage-dependent calcium channel subunit alpha-2/delta-3	CACNA2D3	0.0027
365	Dihydrofolate reductase	DHFR	0.0027
2381	Dihydrofolate reductase	DFR1	0.0027
2833	Dihydrofolate reductase	Not Available	0.0027
2931	Dihydrofolate reductase	folA	0.0027
3544	Dihydrofolate reductase	folA	0.0027
3682	Dihydrofolate reductase	folA	0.0027
6642	Dihydrofolate reductase	folA	0.0027
6756	Dihydrofolate reductase	dfrA	0.0027
3802	Sodium channel protein type 2 subunit alpha	SCN2A	0.0027
889	3-oxoacyl-[acyl-carrier-protein] synthase 1	fabB	0.0027
6860	3-oxoacyl-[acyl-carrier-protein] synthase 1	kasA	0.0027
5787	Angiopoietin-1 receptor	TEK	0.0026
6169	ATP-binding cassette sub-family A member 5	ABCA5	0.0026
358	Cystathionine beta-synthase	CBS	0.0026
763	Tyrosine aminotransferase	TAT	0.0026
5493	Tyrosine aminotransferase	Not Available	0.0026
426	Aspartate aminotransferase, mitochondrial	GOT2	0.0026
914	Formimidoyltransferase-cyclodeaminase	FTCD	0.0026
6316	ADP-ribosylation factor 1	ARF1	0.0025
2157	NAD(P)H dehydrogenase [quinone] 1	NQO1	0.0025
4252	Penicillin-binding protein 5	dacA	0.0025
6043	Putative G-protein coupled receptor 44	GPR44	0.0025
813	Neuronal acetylcholine receptor subunit alpha-2	CHRNA2	0.0025
7	Nitric oxide synthase, inducible	NOS2	0.0025
295	Carbonic anhydrase 1	CA1	0.0025
242	Asparagine synthetase [glutamine-hydrolyzing]	ASNS	0.0025
780	Retinoic acid receptor RXR-gamma	RXRG	0.0025
586	Aspartate aminotransferase, cytoplasmic	GOT1	0.0025
210	Bifunctional aminoacyl-tRNA synthetase [Includes: Glutamyl-tRNA synthetase	EPRS	0.0024
84	Nuclear receptor 0B1	NR0B1	0.0024
1192	Sulfotransferase 1A1	SULT1A1	0.0024
6126	Carbonic anhydrase 7	CA7	0.0024
5961	Insulin	INS	0.0024
908	Glutathione S-transferase theta-1	GSTT1	0.0024
1867	Major prion protein	PRNP	0.0024
823	Fibroblast growth factor receptor 2	FGFR2	0.0024
334	S-adenosylmethionine synthetase isoform type-2	MAT2A	0.0024
5766	NAD-dependent deacetylase sirtuin-5	SIRT5	0.0024
159	Penicillin-binding protein 2B	penA	0.0024
6121	Penicillin-binding protein 2B	penA	0.0024
518	Peroxidase/catalase T	katG	0.0024
6231	Pepsin A	PGA3	0.0024
6527	Lymphocyte antigen 96	LY96	0.0024
6755	Poliovirus receptor	PVR	0.0024
633	Penicillin-binding proteins 1A/1B	pbpA	0.0024
620	Bifunctional dihydrofolate reductase-thymidylate synthase	Not Available	0.0024
1457	Long-chain-fatty-acid--CoA ligase 4	ACSL4	0.0023
332	Beta-lactamase	blaZ	0.0023
2478	Beta-lactamase	ampC	0.0023
2613	Beta-lactamase	ampC	0.0023
2635	Beta-lactamase	ampC	0.0023
2700	Beta-lactamase	penP	0.0023
5445	Beta-lactamase	blaB	0.0023
6019	Beta-lactamase	SHV-7	0.0023
6701	Beta-lactamase	cphA	0.0023
574	Branched-chain-amino-acid aminotransferase, cytosolic	BCAT1	0.0023
453	S-adenosylmethionine synthetase isoform type-1	MAT1A	0.0023
293	Gamma-glutamyl hydrolase	GGH	0.0023
795	Branched-chain-amino-acid aminotransferase, mitochondrial	BCAT2	0.0023
88	Retinoic acid receptor RXR-beta	RXRB	0.0023
2298	Cytochrome P450-cam	camC	0.0023
194	NADH dehydrogenase [ubiquinone] 1 subunit C2	NDUFC2	0.0023
102	DNA topoisomerase I, mitochondrial	TOP1MT	0.0023
871	Glucocorticoid receptor	NR3C1	0.0023
162	Retinoic acid receptor gamma-1	RARG	0.0023
436	5-hydroxytryptamine 2B receptor	HTR2B	0.0022
1525	Heparin-binding growth factor 2	FGF2	0.0022
113	S-adenosylmethionine decarboxylase proenzyme	AMD1	0.0022
6103	Arylamine N-acetyltransferase 1	NAT1	0.0022
6750	ADP-ribosylation factor 6	ARF6	0.0022
6524	Protein tonB	tonB	0.0022
4373	Medium-chain-fatty-acid--CoA ligase	Not Available	0.0022
2290	ADP-ribosyl cyclase 2	BST1	0.0022
131	Synaptic vesicular amine transporter	SLC18A2	0.0021
569	Retinal dehydrogenase 2	ALDH1A2	0.0021
427	Substance-P receptor	TACR1	0.0021
707	72 kDa type IV collagenase	MMP2	0.0021
6459	Glycodelin	PAEP	0.0021
6209	30S ribosomal protein S19	rpsS	0.0021
6712	30S ribosomal protein S19	rpsS	0.0021
6726	30S ribosomal protein S19	rpsS	0.0021
6207	30S ribosomal protein S14	rpsN	0.0021
389	Amiloride-sensitive cation channel 2, neuronal	ACCN2	0.0021
331	Retinol-binding protein I, cellular	RBP1	0.0021
2616	Ganglioside GM2 activator	GM2A	0.0021
228	Beta platelet-derived growth factor receptor	PDGFRB	0.0021
458	Neuronal acetylcholine receptor subunit alpha-10	CHRNA10	0.0021
4162	Potassium voltage-gated channel subfamily KQT member 3	KCNQ3	0.002
1650	Heme carrier protein 1	SLC46A1	0.002
6149	Solute carrier family 22 member 10	SLC22A10	0.002
6501	Fatty acid-binding protein, liver	FABP1	0.002
611	Retinal dehydrogenase 1	ALDH1A1	0.002
1787	Nuclear factor NF-kappa-B p105 subunit	NFKB1	0.002
2435	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase	lpxC	0.002
6613	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase	lpxC	0.002
124	Histamine H2 receptor	HRH2	0.002
137	FolC bifunctional protein [Includes: Folylpolyglutamate synthase	folC	0.002
3809	Estrogen-related receptor gamma	ESRRG	0.002
276	Sodium- and chloride-dependent GABA transporter 1	SLC6A1	0.002
432	D(4) dopamine receptor	DRD4	0.002
822	Aldose reductase	AKR1B1	0.002
796	Inosine-5'-monophosphate dehydrogenase 2	IMPDH2	0.0019
718	Folate receptor gamma	FOLR3	0.0019
299	Folate receptor beta	FOLR2	0.0019
804	Mitochondrial folate transporter/carrier	SLC25A32	0.0019
182	2-oxoglutarate dehydrogenase E1 component, mitochondrial	OGDH	0.0019
1353	DNA topoisomerase 1	TOP1	0.0019
3552	DNA topoisomerase 1	topA	0.0019
838	Inosine-5'-monophosphate dehydrogenase 1	IMPDH1	0.0019
723	Cytosolic phospholipase A2	PLA2G4A	0.0019
245	Large neutral amino acids transporter small subunit 1	SLC7A5	0.0019
337	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial	NDUFS7	0.0019
214	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	NDUFS3	0.0019
3126	Poly [ADP-ribose] polymerase 1	PARP1	0.0019
6140	Ileal sodium/bile acid cotransporter	SLC10A2	0.0019
803	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	NDUFS2	0.0019
193	Beta-1 adrenergic receptor	ADRB1	0.0019
6263	cAMP-dependent protein kinase catalytic subunit alpha	PRKACA	0.0019
725	5-hydroxytryptamine 1D receptor	HTR1D	0.0019
1517	Beta-3 adrenergic receptor	ADRB3	0.0019
6154	Multidrug and toxin extrusion protein 1	SLC47A1	0.0019
2297	Genome polyprotein	Not Available	0.0019
2322	Genome polyprotein	Not Available	0.0019
2694	Genome polyprotein	Not Available	0.0019
2719	Genome polyprotein	Not Available	0.0019
2860	Genome polyprotein	Not Available	0.0019
2928	Genome polyprotein	Not Available	0.0019
3160	Genome polyprotein	Not Available	0.0019
3260	Genome polyprotein	Not Available	0.0019
4783	Genome polyprotein	Not Available	0.0019
5726	Genome polyprotein	Not Available	0.0019
5779	Genome polyprotein	Not Available	0.0019
5867	Genome polyprotein	Not Available	0.0019
6253	Genome polyprotein	Not Available	0.0019
6301	Genome polyprotein	Not Available	0.0019
6380	Genome polyprotein	Not Available	0.0019
6381	Genome polyprotein	Not Available	0.0019
6437	Genome polyprotein	Not Available	0.0019
6520	Genome polyprotein	Not Available	0.0019
6521	Genome polyprotein	Not Available	0.0019
6652	Genome polyprotein	Not Available	0.0019
6734	Genome polyprotein	Not Available	0.0019
6735	Genome polyprotein	Not Available	0.0019
6736	Genome polyprotein	Not Available	0.0019
6737	Genome polyprotein	Not Available	0.0019
6738	Genome polyprotein	Not Available	0.0019
6739	Genome polyprotein	Not Available	0.0019
6744	Genome polyprotein	Not Available	0.0019
6748	Genome polyprotein	Not Available	0.0019
6894	Genome polyprotein	Not Available	0.0019
6898	Genome polyprotein	Not Available	0.0019
6033	High affinity interleukin-8 receptor A	CXCR1	0.0018
199	Monocarboxylate transporter 8	SLC16A2	0.0018
6861	Alcohol dehydrogenase [NADP+]	AKR1A1	0.0018
6931	Calcium-activated potassium channel subunit beta-1	KCNMB1	0.0018
6933	Calcium-activated potassium channel subunit beta-4	KCNMB4	0.0018
6932	Calcium-activated potassium channel subunit beta-3	KCNMB3	0.0018
6934	Small conductance calcium-activated potassium channel protein 1	KCNN1	0.0018
6935	Small conductance calcium-activated potassium channel protein 2	KCNN2	0.0018
6936	Small conductance calcium-activated potassium channel protein 3	KCNN3	0.0018
204	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE5A	0.0018
3312	Fatty acid-binding protein, brain	FABP7	0.0018
864	Gag-Pol polyprotein	gag-pol	0.0018
2237	Gag-Pol polyprotein	gag-pol	0.0018
2326	Gag-Pol polyprotein	gag-pol	0.0018
2451	Gag-Pol polyprotein	gag-pol	0.0018
2901	Gag-Pol polyprotein	gag-pol	0.0018
3165	Gag-Pol polyprotein	gag-pol	0.0018
3722	Gag-Pol polyprotein	gag-pol	0.0018
6306	Gag-Pol polyprotein	gag-pol	0.0018
6624	Gag-Pol polyprotein	gag-pol	0.0018
1198	Serum paraoxonase/arylesterase 1	PON1	0.0018
6223	Penicillin-binding protein 1C	pbpC	0.0018
275	Arachidonate 5-lipoxygenase	ALOX5	0.0017
6163	Copper-transporting ATPase 2	ATP7B	0.0017
6165	Copper-transporting ATPase 1	ATP7A	0.0017
1714	Mitogen-activated protein kinase 3	MAPK3	0.0017
1256	5-hydroxytryptamine 6 receptor	HTR6	0.0017
1291	cAMP response element-binding protein	CREB1	0.0017
751	Potassium channel subfamily K member 6	KCNK6	0.0017
229	Retinoic acid receptor beta	RARB	0.0017
170	Succinate semialdehyde dehydrogenase, mitochondrial	ALDH5A1	0.0017
6146	High affinity copper uptake protein 1	SLC31A1	0.0017
778	Cysteinyl leukotriene receptor 1	CYSLTR1	0.0017
730	Retinoic acid receptor alpha	RARA	0.0017
1360	Sphingomyelin phosphodiesterase	SMPD1	0.0016
2180	3-phosphoinositide-dependent protein kinase 1	PDPK1	0.0016
4152	Superoxide dismutase [Cu-Zn]	SOD1	0.0016
3616	Fatty acid-binding protein, epidermal	FABP5	0.0016
5431	Lipid binding protein	Not Available	0.0016
5433	UPF0230 protein TM_1468	TM_1468	0.0016
5430	Hepatocyte nuclear factor 4-gamma	HNF4G	0.0016
5463	Calcium-activated potassium channel subunit beta 2	KCNMB2	0.0016
3601	Dihydropteroate synthase 1	folP1	0.0016
3807	Dihydropteroate synthase 1	folP1	0.0016
3808	Dihydropteroate synthase 2	folP2	0.0016
244	Angiotensin-converting enzyme	ACE	0.0016
40	RAF proto-oncogene serine/threonine-protein kinase	RAF1	0.0016
816	Biliverdin reductase A	BLVRA	0.0016
579	Alcohol dehydrogenase class 4 mu/sigma chain	ADH7	0.0016
316	4-trimethylaminobutyraldehyde dehydrogenase	ALDH9A1	0.0016
792	Aldehyde dehydrogenase, dimeric NADP-preferring	ALDH3A1	0.0016
26	Vascular endothelial growth factor receptor 3	FLT4	0.0015
606	Cytochrome P450 27, mitochondrial	CYP27A1	0.0015
291	Nitric-oxide synthase, endothelial	NOS3	0.0015
2427	Ferrichrome-iron receptor	fhuA	0.0015
614	Progesterone receptor	PGR	0.0015
6228	Nuclear receptor coactivator 1	NCOA1	0.0015
581	Cytochrome P450 2R1	CYP2R1	0.0015
4177	Proto-oncogene tyrosine-protein kinase receptor ret	RET	0.0015
3913	Glutamic acid decarboxylase	GAD65	0.0015
1502	Peroxisome proliferator-activated receptor delta	PPARD	0.0015
32	Vascular endothelial growth factor receptor 1	FLT1	0.0015
950	Alpha platelet-derived growth factor receptor	PDGFRA	0.0015
650	Aldo-keto reductase family 1 member C3	AKR1C3	0.0015
6179	UDP-glucuronosyltransferase 2B17	UGT2B17	0.0015
6206	DNA-directed RNA polymerase subunit beta'	rpoC	0.0014
6038	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6H	0.0014
6264	cAMP-dependent protein kinase inhibitor alpha	PKIA	0.0014
896	Glutathione S-transferase Mu 1	GSTM1	0.0014
6080	Neuronal acetylcholine receptor subunit alpha-5	CHRNA5	0.0014
6082	Neuronal acetylcholine receptor subunit beta-3	CHRNB3	0.0014
948	Neuronal acetylcholine receptor subunit beta-2	CHRNB2	0.0014
219	NADH-ubiquinone oxidoreductase chain 3	MT-ND3	0.0014
343	NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial	NDUFC1	0.0014
607	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2	NDUFA2	0.0014
300	NADH-ubiquinone oxidoreductase chain 4L	MT-ND4L	0.0014
374	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1	NDUFB1	0.0014
446	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7	NDUFA7	0.0014
247	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	NDUFA1	0.0014
236	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6	NDUFA6	0.0014
582	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13	NDUFA13	0.0014
190	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4	NDUFA4	0.0014
755	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3	NDUFA3	0.0014
353	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2	NDUFA4L2	0.0014
602	Acyl carrier protein, mitochondrial	NDUFAB1	0.0014
313	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3	NDUFB3	0.0014
555	NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial	NDUFS4	0.0014
475	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial	NDUFB2	0.0014
99	NADH dehydrogenase [ubiquinone] iron-sulfur protein 5	NDUFS5	0.0014
30	NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial	NDUFV3	0.0014
525	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	NDUFA5	0.0014
41	NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial	NDUFS8	0.0014
272	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10	NDUFB10	0.0014
104	NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial	NDUFS6	0.0014
417	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6	NDUFB6	0.0014
656	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9	NDUFB9	0.0014
324	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4	NDUFB4	0.0014
50	Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating	NSDHL	0.0014
568	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7	NDUFB7	0.0014
598	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11	NDUFA11	0.0014
152	NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial	NDUFV2	0.0014
829	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12	NDUFA12	0.0014
609	15-hydroxyprostaglandin dehydrogenase [NAD+]	HPGD	0.0014
721	NADH-ubiquinone oxidoreductase chain 2	MT-ND2	0.0014
107	C-4 methylsterol oxidase	SC4MOL	0.0014
608	NADH-ubiquinone oxidoreductase chain 4	MT-ND4	0.0014
496	Aldehyde dehydrogenase 3B1	ALDH3B1	0.0014
405	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8	NDUFA8	0.0014
34	7-dehydrocholesterol reductase	DHCR7	0.0014
384	NADH-ubiquinone oxidoreductase chain 6	MT-ND6	0.0014
372	Estradiol 17-beta-dehydrogenase 3	HSD17B3	0.0014
644	Heme oxygenase 2	HMOX2	0.0014
4982	Heme oxygenase 2	pbsA2	0.0014
729	GDP-L-fucose synthetase	TSTA3	0.0014
3463	GDP-L-fucose synthetase	fcl	0.0014
487	Aldo-keto reductase family 1 member C4	AKR1C4	0.0014
746	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial	NDUFB8	0.0014
167	L-lactate dehydrogenase C chain	LDHC	0.0014
326	L-lactate dehydrogenase A-like 6A	LDHAL6A	0.0014
270	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial	NDUFB5	0.0014
141	3-hydroxyisobutyrate dehydrogenase, mitochondrial	HIBADH	0.0014
206	3-keto-steroid reductase	HSD17B7	0.0014
196	D-beta-hydroxybutyrate dehydrogenase, mitochondrial	BDH1	0.0014
231	Glycerol-3-phosphate dehydrogenase [NAD+], cytoplasmic	GPD1	0.0014
91	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial	NDUFA10	0.0014
14	Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial	IDH3A	0.0014
112	L-lactate dehydrogenase A-like 6B	LDHAL6B	0.0014
216	Aldehyde dehydrogenase 3B2	ALDH3B2	0.0014
9	Estradiol 17-beta-dehydrogenase 2	HSD17B2	0.0014
145	Corticosteroid 11-beta-dehydrogenase isozyme 2	HSD11B2	0.0014
637	NADH-ubiquinone oxidoreductase chain 5	MT-ND5	0.0014
662	Fatty aldehyde dehydrogenase	ALDH3A2	0.0014
671	Pyruvate dehydrogenase E1 component alpha subunit, testis-specific form, mitochondrial	PDHA2	0.0014
711	UDP-glucose 6-dehydrogenase	UGDH	0.0014
3672	UDP-glucose 6-dehydrogenase	hasB	0.0014
149	Alpha-aminoadipic semialdehyde dehydrogenase	ALDH7A1	0.0014
531	Aldehyde dehydrogenase X, mitochondrial	ALDH1B1	0.0014
180	D-3-phosphoglycerate dehydrogenase	PHGDH	0.0014
3726	D-3-phosphoglycerate dehydrogenase	serA	0.0014
4291	D-3-phosphoglycerate dehydrogenase	serA	0.0014
258	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	ALDH6A1	0.0014
271	Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial	ALDH4A1	0.0014
335	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial	NDUFA9	0.0014
616	Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial	IDH3B	0.0014
628	Pyruvate dehydrogenase E1 component alpha subunit, somatic form, mitochondrial	PDHA1	0.0014
848	Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial	IDH3G	0.0014
643	Peroxisomal bifunctional enzyme	EHHADH	0.0014
548	NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial	NDUFS1	0.0014
288	Trifunctional enzyme subunit alpha, mitochondrial	HADHA	0.0014
393	GDH/6PGL endoplasmic bifunctional protein [Includes: Glucose 1-dehydrogenase	H6PD	0.0014
539	NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial	NDUFV1	0.0014
3854	Basic fibroblast growth factor receptor 1	FGFR1	0.0014
469	Annexin A1	ANXA1	0.0014
1483	Membrane copper amine oxidase	AOC3	0.0014
368	Enoyl-[acyl-carrier-protein] reductase [NADH]	inhA	0.0014
3228	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0014
3678	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0014
6856	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0014
350	3-hydroxyacyl-CoA dehydrogenase type-2	HSD17B10	0.0014
646	Malate dehydrogenase, cytoplasmic	MDH1	0.0013
6037	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6G	0.0013
178	NADH-cytochrome b5 reductase 3	CYB5R3	0.0013
454	Peroxisomal multifunctional enzyme type 2	HSD17B4	0.0013
812	Dihydrolipoyl dehydrogenase, mitochondrial	DLD	0.0013
597	Dihydropteridine reductase	QDPR	0.0013
328	Sorbitol dehydrogenase	SORD	0.0013
396	Alcohol dehydrogenase 4	ADH4	0.0013
363	NADP-dependent malic enzyme, mitochondrial	ME3	0.0013
284	DNA-directed RNA polymerase beta chain	rpoB	0.0013
5773	DNA-directed RNA polymerase beta chain	rpoB	0.0013
2222	Equilibrative nucleoside transporter 1	SLC29A1	0.0013
283	SEC14-like protein 2	SEC14L2	0.0013
4097	Neuronal acetylcholine receptor subunit alpha-9	CHRNA9	0.0013
976	Platelet glycoprotein IX	GP9	0.0013
6081	Neuronal acetylcholine receptor subunit alpha-6	CHRNA6	0.0013
1630	Integrin beta-2	ITGB2	0.0013
400	Coagulation factor IX	F9	0.0013
5461	Coagulation factor IX	F9	0.0013
1374	Natriuretic peptides B	NPPB	0.0013
1827	Gap junction alpha-1 protein	GJA1	0.0013
514	Potassium voltage-gated channel subfamily H member 6	KCNH6	0.0013
772	Potassium voltage-gated channel subfamily H member 7	KCNH7	0.0013
1908	Vascular cell adhesion protein 1	VCAM1	0.0013
3970	Voltage-dependent N-type calcium channel subunit alpha-1B	CACNA1B	0.0013
6182	Cytochrome P450 2J2	CYP2J2	0.0013
1405	Thiopurine S-methyltransferase	TPMT	0.0013
635	Estradiol 17-beta-dehydrogenase 8	HSD17B8	0.0012
666	NADP-dependent malic enzyme	ME1	0.0012
814	Ryanodine receptor 1	RYR1	0.0012
3221	Cytochrome c4	cc4	0.0012
419	Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial	HADH	0.0012
4112	Voltage-dependent L-type calcium channel subunit beta-4	CACNB4	0.0012
4114	Voltage-dependent L-type calcium channel subunit beta-3	CACNB3	0.0012
857	Malate dehydrogenase, mitochondrial	MDH2	0.0012
6078	Neuronal acetylcholine receptor subunit beta-4	CHRNB4	0.0012
77	L-lactate dehydrogenase B chain	LDHB	0.0012
12	Alcohol dehydrogenase class 3	ADH5	0.0012
810	Heme oxygenase 1	HMOX1	0.0012
3391	Heme oxygenase 1	pbsA1	0.0012
4081	Vitamin K epoxide reductase complex subunit 1-like protein 1	VKORC1L1	0.0012
248	Pyrroline-5-carboxylate reductase 1	PYCR1	0.0012
802	Pyrroline-5-carboxylate reductase 2	PYCR2	0.0012
604	Vitamin K-dependent protein Z	PROZ	0.0012
626	Cysteine dioxygenase type 1	CDO1	0.0012
296	Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial	MTHFD2	0.0012
6026	Alcohol dehydrogenase 6	ADH6	0.0012
407	Vascular endothelial growth factor receptor 2	KDR	0.0012
4226	Uridine phosphorylase 2	UPP2	0.0012
4217	Telomerase reverse transcriptase	TERT	0.0012
110	Pyruvate dehydrogenase E1 component subunit beta, mitochondrial	PDHB	0.0012
627	11-cis retinol dehydrogenase	RDH5	0.0012
640	Aldehyde dehydrogenase 1A3	ALDH1A3	0.0012
66	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II	HSD3B2	0.0012
6046	Voltage-gated calcium channel beta 1 subunit splice variant CavB1d	CACNB1	0.0012
11	NAD(P) transhydrogenase, mitochondrial	NNT	0.0012
839	Short-chain specific acyl-CoA dehydrogenase, mitochondrial	ACADS	0.0012
599	Glyceraldehyde-3-phosphate dehydrogenase	GAPDH	0.0011
4426	Glyceraldehyde-3-phosphate dehydrogenase	gap	0.0011
4454	Glyceraldehyde-3-phosphate dehydrogenase	gap	0.0011
4489	Glyceraldehyde-3-phosphate dehydrogenase	gap	0.0011
794	Glyceraldehyde-3-phosphate dehydrogenase, testis-specific	GAPDHS	0.0011
74	Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial	DLAT	0.0011
24	Thymidylate synthase	TMP1	0.0011
359	Thymidylate synthase	TYMS	0.0011
2626	Thymidylate synthase	thyA	0.0011
2729	Thymidylate synthase	thyA	0.0011
5352	Thymidylate synthase	THYA	0.0011
4225	Uridine phosphorylase 1	UPP1	0.0011
333	Voltage-dependent L-type calcium channel subunit beta-1	CACNB1	0.0011
719	Retinoic acid receptor responder protein 1	RARRES1	0.0011
770	Retinoic acid-induced protein 3	GPRC5A	0.0011
13	Aminomethyltransferase, mitochondrial	AMT	0.0011
268	Adenosine A2b receptor	ADORA2B	0.0011
422	Vitamin K-dependent protein C	PROC	0.0011
1245	Vitamin K-dependent protein S	PROS1	0.0011
166	NAD-dependent malic enzyme, mitochondrial	ME2	0.0011
57	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I	HSD3B1	0.0011
856	Vitamin D3 receptor	VDR	0.0011
6124	Carbonic anhydrase 5B, mitochondrial	CA5B	0.001
2461	D-alanyl-D-alanine carboxypeptidase	Not Available	0.001
5756	D-alanyl-D-alanine carboxypeptidase	dac	0.001
3238	Multidrug resistance protein mexA	mexA	0.001
3709	Glycerol uptake facilitator protein	glpF	0.001
3116	Bacterioferritin	bfr	0.001
4906	Bacterioferritin	bfr	0.001
4965	Bacterioferritin	bfr	0.001
5489	Ribonucleoside-diphosphate reductase 1 subunit beta	nrdB	0.001
3173	Enolase	eno	0.001
3336	C4-dicarboxylate transport transcriptional regulatory protein dctD	dctD	0.001
413	Amidophosphoribosyltransferase	PPAT	0.001
2515	Amidophosphoribosyltransferase	purF	0.001
3714	Amidophosphoribosyltransferase	purF	0.001
3393	TGF-beta receptor type-2	TGFBR2	0.001
679	C-1-tetrahydrofolate synthase, cytoplasmic	MTHFD1	0.001
279	Tyrosinase	TYR	0.001
5798	Mitogen-activated protein kinase 11	MAPK11	0.001
6131	Carbonic anhydrase 14	CA14	0.001
2021	Thrombomodulin	THBD	0.001
267	Plasminogen activator inhibitor 1	SERPINE1	0.001
163	D(1B) dopamine receptor	DRD5	0.001
654	Flavin reductase	BLVRB	0.001
217	Estradiol 17-beta-dehydrogenase 1	HSD17B1	0.0009
2320	Thymidine kinase, cytosolic	TK1	0.0009
3961	G protein-activated inward rectifier potassium channel 4	KCNJ5	0.0009
997	Protein kinase C beta type	PRKCB	0.0009
6122	Carbonic anhydrase 3	CA3	0.0009
1275	Estrogen sulfotransferase	SULT1E1	0.0009
233	Potassium channel subfamily K member 2	KCNK2	0.0009
1864	RET proto-oncogene	RET	0.0009
2852	DNA mismatch repair protein mutL	mutL	0.0009
6123	Carbonic anhydrase 5A, mitochondrial	CA5A	0.0009
1950	Epithelial discoidin domain-containing receptor 1	DDR1	0.0009
6170	ATP-binding cassette sub-family A member 3	ABCA3	0.0009
6094	BCR/ABL fusion protein isoform X9	BCR/ABL fusion	0.0009
634	Squalene monooxygenase	SQLE	0.0009
7196	Squalene monooxygenase	ERG1	0.0009
5278	Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1	PAPSS1	0.0009
798	Osteocalcin	BGLAP	0.0009
4192	DNA topoisomerase 2-beta	TOP2B	0.0009
3191	Histidinol dehydrogenase	hisD	0.0009
6221	Steroid hormone receptor ERR1	ESRRA	0.0009
564	Cellular retinoic acid-binding protein 1	CRABP1	0.0009
1970	Protein kinase C alpha type	PRKCA	0.0009
528	5-hydroxytryptamine 1E receptor	HTR1E	0.0009
714	Glutathione reductase, mitochondrial	GSR	0.0009
859	Cellular retinoic acid-binding protein 2	CRABP2	0.0009
2408	Tyrosine-protein kinase SYK	SYK	0.0009
3007	Carbonic anhydrase 12	CA12	0.0009
4205	Carbonic anhydrase 9	CA9	0.0009
740	Argininosuccinate synthase	ASS1	0.0009
865	Argininosuccinate synthase	ASS1	0.0009
2680	Argininosuccinate synthase	argG	0.0009
3194	Argininosuccinate synthase	argG	0.0009
6172	ATP-binding cassette sub-family B member 8, mitochondrial	ABCB8	0.0008
1039	Histone deacetylase 9	HDAC9	0.0008
3639	Thymidine phosphorylase	deoA	0.0008
3936	Thymidine phosphorylase	TYMP	0.0008
1302	Dihydropyrimidine dehydrogenase [NADP+]	DPYD	0.0008
6161	Probable low affinity copper uptake protein 2	SLC31A2	0.0008
4311	tRNA	TRDMT1	0.0008
4325	tRNA	trmD	0.0008
4328	tRNA	trmD	0.0008
6218	Pannexin-1	PANX1	0.0008
4692	A/G-specific adenine glycosylase	mutY	0.0008
521	ATP-binding cassette transporter sub-family C member 9	ABCC9	0.0008
369	Coagulation factor VII	F7	0.0008
936	Ephrin type-A receptor 2	EPHA2	0.0008
1971	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	PDE4A	0.0008
165	FL cytokine receptor	FLT3	0.0008
132	ATP-binding cassette sub-family A member 1	ABCA1	0.0007
6042	Prostaglandin reductase 2	PTGR2	0.0007
630	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial	ACADSB	0.0007
951	Macrophage colony-stimulating factor 1 receptor	CSF1R	0.0007
3957	Adenosine deaminase	ADA	0.0007
5818	Folate receptor alpha	FOLR1	0.0007
6168	Solute carrier family 22 member 16	SLC22A16	0.0007
2802	Endoglucanase G	celCCG	0.0007
76	Nitric-oxide synthase, brain	NOS1	0.0007
1792	Tissue-type plasminogen activator	PLAT	0.0007
273	Apoptosis regulator Bcl-2	BCL2	0.0007
2101	Glutathione-requiring prostaglandin D synthase	HPGDS	0.0007
2236	Casein kinase II subunit alpha	CSNK2A1	0.0007
709	ATP-sensitive inward rectifier potassium channel 1	KCNJ1	0.0006
4954	Soluble cytochrome b558	Not Available	0.0006
4943	Cytochrome c6	petJ	0.0006
4925	Cytochrome c-type protein SHP	shp	0.0006
4916	Cyanoglobin	glbN	0.0006
4994	Hemoglobin-like protein HbO	glbO	0.0006
4947	Bacterial hemoglobin	vhb	0.0006
4975	Cytochrome c-556	RPA3973	0.0006
4984	Neuroglobin	NGB	0.0006
5000	HemO	hemO	0.0006
4942	Diheme cytochrome c napB	napB	0.0006
4981	Iron-starvation protein PigA	pigA	0.0006
4915	Cytochrome c-550	psbV	0.0006
4959	Cytochrome c-550	psbV	0.0006
5216	Cytochrome c-550	psbV	0.0006
4934	Cytochrome c-551	nirM	0.0006
5218	Cytochrome c-551	nirM	0.0006
4905	Cytochrome c2	Not Available	0.0006
4939	Cytochrome c2	cycA	0.0006
4964	Cytochrome c2	cycA	0.0006
4979	Cytochrome c2	cycA	0.0006
6673	Cytochrome c2	cycA	0.0006
4910	Cytoglobin	CYGB	0.0006
4935	Cytochrome c-554	cycA1	0.0006
4936	Cytochrome c2 iso-2	Not Available	0.0006
4909	CooA protein	cooA	0.0006
4998	Hemoglobin-like protein yjbI	yjbI	0.0006
4907	Cytochrome c-L	moxG	0.0006
6865	Cytochrome c-L	moxG	0.0006
4961	Hemophore HasA	hasA	0.0006
4971	Nonaheme cytochrome c	hmcA	0.0006
4903	Methyl-accepting chemotaxis protein	Tar4	0.0006
4931	Cytochrome P450 167A1	CYP167A1	0.0006
4976	Apocytochrome f	petA	0.0006
6407	Apocytochrome f	petA	0.0006
4972	P450cin	cinA	0.0006
4937	Cytochrome oxidase subunit II	rcoxA	0.0006
4904	Cytochrome c family protein	GSU1996	0.0006
4999	Cytochrome P450 165B3	CYP165B3	0.0006
4764	Cytochrome P450 165C4	CYP165C4	0.0006
4960	Putative cytochrome P450-family protein	SCO7417	0.0006
4926	Heme-based aerotactic transducer hemAT	hemAT	0.0006
4970	Cytochrome c nitrite reductase catalytic subunit	nrfA	0.0006
4989	Cytochrome c551 peroxidase	ccp	0.0006
5222	Cytochrome c551 peroxidase	ccpA	0.0006
4922	Cytochrome c, putative	SO_4144	0.0006
4993	Hydroxylamine oxidoreductase	hao1	0.0006
4908	Heme-regulated cyclic AMP phosphodiesterase	dosP	0.0006
4952	Catalase/peroxidase	katA	0.0006
3093	Catalase HPII	katE	0.0006
239	Coagulation factor X	F10	0.0006
5251	Carbonyl reductase [NADPH] 1	CBR1	0.0006
1313	Lactoylglutathione lyase	GLO1	0.0006
489	Monocarboxylate transporter 2	SLC16A7	0.0005
164	Histamine H4 receptor	HRH4	0.0005
2287	Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase	ATIC	0.0005
952	Dipeptidyl peptidase 4	DPP4	0.0005
54	Prothrombin	F2	0.0005
6160	Solute carrier organic anion transporter family member 3A1	SLCO3A1	0.0005
4920	Peroxidase/catalase	katG	0.0005
4948	Cytochrome c-553	Not Available	0.0004
4923	Cytochrome c3	DvMF_2499	0.0004
4945	Cytochrome c3	Not Available	0.0004
4949	Cytochrome c3	DVU_3171	0.0004
4968	Cytochrome c3	cytc3	0.0004
4997	Cytochrome c3	SO_2727	0.0004
5219	Cytochrome c3	cyd	0.0004
2119	Cytochrome b5	CYB5A	0.0004
4902	Nine-heme cytochrome c	Ddes_2038	0.0004
3189	High-molecular-weight cytochrome c	hmcA	0.0004
4990	PpcA	ppcA	0.0004
4956	Quinohemoprotein alcohol dehydrogenase ADH IIB	qbdA	0.0004
3375	Acidic cytochrome c3	Not Available	0.0004
4988	Sulfite oxidase, mitochondrial	SUOX	0.0004
2915	Sensor protein fixL	fixL	0.0004
4944	Sensor protein fixL	fixL	0.0004
4037	Hypothetical protein	GPX1	0.0004
4297	Hypothetical protein	SP_1951	0.0004
4521	Hypothetical protein	BC_2969	0.0004
4540	Hypothetical protein	TM_1070	0.0004
4555	Hypothetical protein	MT1739	0.0004
4569	Hypothetical protein	mshD	0.0004
4578	Hypothetical protein	PA3270	0.0004
4747	Hypothetical protein	PA3967	0.0004
5177	Hypothetical protein	TM_0096	0.0004
5194	Hypothetical protein	PA1204	0.0004
5240	Hypothetical protein	Rv2991	0.0004
5370	Hypothetical protein	TM_1158	0.0004
5710	Hypothetical protein	Tb927.5.1360	0.0004
3570	Cytochrome P450 152A1	cypC	0.0004
4813	Heme oxygenase	hmuO	0.0004
5769	Heme oxygenase	Not Available	0.0004
4385	Cytochrome c'	Not Available	0.0004
4967	Cytochrome c'	cycA	0.0004
5038	Cytochrome c'	Not Available	0.0004
5223	Cytochrome c'	cycP	0.0004
4289	Cytochrome P450	TT_P0059	0.0004
6262	Cytochrome P450	staP	0.0004
4992	Cytochrome c peroxidase	Not Available	0.0004
3411	Cytochrome P450 121	cyp121	0.0004
3670	Soluble cytochrome b562 precursor	cybC	0.0004
3291	Cytochrome c-552	cycA	0.0004
4927	Cytochrome c-552	nrfA	0.0004
4938	Cytochrome c-552	cycA	0.0004
4953	Cytochrome c-552	nrfA	0.0004
5217	Cytochrome c-552	cycM	0.0004
2617	Nitric oxide synthase oxygenase	nos	0.0004
2701	Nitric oxide synthase oxygenase	nos	0.0004
4386	Hemoglobin-like protein HbN	glbN	0.0004
3102	Flavohemoprotein	hmp	0.0004
4969	Flavohemoprotein	hmp	0.0004
3127	Nitrite reductase	nirS	0.0004
3284	Nitrite reductase	nirS	0.0004
2845	Bifunctional P-450:NADPH-P450 reductase	CYP102A1	0.0004
2972	6-deoxyerythronolide B hydroxylase	eryF	0.0003
605	Fumarate reductase flavoprotein subunit	frdA	0.0003
2709	Fumarate reductase flavoprotein subunit	SO_0970	0.0003
3673	Fumarate reductase flavoprotein subunit	fccA	0.0003
4912	Fumarate reductase flavoprotein subunit	ifcA	0.0003
6549	Fumarate reductase flavoprotein subunit	frdA	0.0003
4608	Putative cytochrome P450	SCO1207	0.0003
4963	Putative cytochrome P450	SCO2884	0.0003
6254	Putative cytochrome P450	SCO6998	0.0003
693	Hemoglobin subunit beta	HBB	0.0003
6268	Hydroxyacid oxidase 1	HAO1	0.0003

(*) Categorization taken from DrugBank: therapeutic category or general category of a drug (i.e. anti-convulsant, antibacterial, etc.)

DB00753 - Isoflurane

Targets

Enzymes

Carriers

Predictions