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Methionyl-tRNA formyltransferase


Partner ID 6588
Name Methionyl-tRNA formyltransferase
Synonyms 8837
Gene name fmt
General function Translation, ribosomal structure and biogenesis
Specific function Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by:(I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP
Gene sequence + ...

ATGTCAGTTTTGCAAGTGTTACATATTCCGGACGAGCGGCTTCGCAAAGTTGCTAAACCGGTAGAAGAAGTGAATGCAGAAATTCAGCGTATCGTCGATGATATGTTCGAGACGATGTACGCAGAAGAAGGTATTGGCCTGGCGGCAACCCAGGTTGATATCCATCAACGTATCATTGTTATTGATGTTTCGGAAAACCGTGACGAACGGCTAGTGTTAATCAATCCAGAGCTTTTAGAAAAAAGCGGCGAAACAGGCATTGAAGAAGGTTGCCTGTCGATCCCTGAACAACGTGCTTTAGTGCCGCGCGCAGAGAAAGTTAAAATTCGCGCCCTTGACCGCGACGGTAAACCATTTGAACTGGAAGCAGACGGTCTGTTAGCCATCTGTATTCAGCATGAGATGGATCACCTGGTCGGCAAACTGTTTATGGATTATCTGTCACCGCTGAAACAACAACGTATTCGTCAGAAAGTTGAAAAACTGGATCGTCTGAAAGCCCGGGCTTAA
Protein sequence + ...

MSESLRIIFAGTPDFAARHLDALLSSGHNVVGVFTQPDRPAGRGKKLMPSPVKVLAEEKGLPVFQPVSLRPQENQQLVAELQADVMVVVAYGLILPKAVLEMPRLGCINVHGSLLPRWRGAAPIQRSLWAGDAETGVTIMQMDVGLDTGDMLYKLSCPITAEDTSGTLYDKLAELGPQGLITTLKQLADGTAKPEVQDETLVTYAEKLSKEEARIDWSLSAAQLERCIRAFNPWPMSWLEIEGQPVKVWKASVIDTATNAAPGTILEANKQGIQVATGDGILNLLSLQPAGKKAMSAQDLLNSRREWFVPGNRLV
GO Classification
function
glycine hydroxymethyltransferase activity
hydroxymethyl-, formyl- and related transferase activity
methionyl-tRNA formyltransferase activity
catalytic activity
transferase activity
transferase activity, transferring one-carbon groups
methyltransferase activity
process
protein biosynthesis
physiological process
metabolism
macromolecule metabolism
biosynthesis
macromolecule biosynthesis
See more information at   →   www.drugbank.ca

Drugs


Associated as Target

Id Name
DB04464 N-Formylmethionine

Associated as Prediction

Id Name
DB00128 L-Aspartic Acid
DB00157 NADH
DB00228 Enflurane
DB00407 Ardeparin
DB00536 Guanidine
DB00569 Fondaparinux sodium
DB00753 Isoflurane
DB00768 Olopatadine
DB01028 Methoxyflurane
DB01109 Heparin
DB01159 Halothane
DB01189 Desflurane
DB01225 Enoxaparin
DB01236 Sevoflurane
DB01373 Calcium
DB01812 Adenosine-3'-5'-Diphosphate
DB01842 3'-Phosphate-Adenosine-5'-Diphosphate
DB01942 Formic Acid
DB01961 Cytidine-3'-Monophosphate
DB02098 Adenosine-2'-5'-Diphosphate
DB02363 2'-Monophosphoadenosine-5'-Diphosphate
DB02573 2'-Deoxycytidine-2'-Deoxyadenosine-3',5'-Monophosphate
DB02659 Cholic Acid
DB02674 4-(2-Oxo-Hexahydro-Thieno[3,4-D]Imidazol-4-Yl)-Butyricacid
DB02714 3'-Uridinemonophosphate
DB02740 3-Indolebutyric Acid
DB02805 1-(3-O-Phosphono-Beta-L-Arabinofuranosyl)Pyrimidine-2,4(1h,3h)-Dione
DB02899 N-Carboxymethionine
DB02944 Alpha-D-Mannose
DB02987 Cysteine-S-Acetamide
DB03112 6-(2-Oxo-Hexahydro-Thieno[3,4-D]Imidazol-4-Yl)-Hexanoic Acid
DB03139 6-[5-(2-Oxo-Hexahydro-Thieno[3,4-D]Imidazol-4-Yl)-Pentanoylamino]-Hexanoic Acid
DB03155 1-(2-Deoxy-2-Fluoro-3-O-Phosphono-Beta-L-Ribofuranosyl)Pyrimidine-2,4(1h,3h)-Dione
DB03186 U-Pi-a-Pi
DB03326 deoxycytidylyl-3',5'-guanosine
DB03353 2-Iminobiotin
DB03431 Adenosine-5'-Diphosphate
DB03447 Uridylyl-2'-5'-Phospho-Adenosine
DB03448 2'-Deoxyuridine 3'-Monophosphate
DB03512 Uridine-2',3'-Vanadate
DB03533 Glycoluril
DB03549 Biotinyl P-Nitroaniline
DB03726 Purine Riboside-5'-Monophosphate
DB03765 Cytidine-2'-Monophosphate
DB03792 5-Amino-1h-Pyrimidine-2,4-Dione
DB03900 2-Methyl-2-Propanol
DB04147 Lauryl Dimethylamine-N-Oxide
DB04272 Citric Acid
DB04464 N-Formylmethionine
DB04514 Phosphoric Acid-2'-[2'-Deoxy-Uridine]Ester-5'-Guanosine Ester
DB04650 5-[(3AS,4R,6AR)-2-OXOHEXAHYDRO-1H-THIENO[3,4-D]IMIDAZOL-4-YL]PENTANOIC ACID
DB06271 Sulodexide
DB06779 Dalteparin
DB06822 Tinzaparin
DB06941 (Z)-2-[2-(4-methylpiperazin-1-yl)benzyl]diazenecarbothioamide
DB07004 2-[(5-hex-1-yn-1-ylfuran-2-yl)carbonyl]-N-methylhydrazinecarbothioamide
DB07349 (1S)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PENTANOYLOXY)METHYL]ETHYL OCTANOATE
DB07392 2-CHLORO-4-ISOPROPYLAMINO-6-ETHYLAMINO -1,3,5-TRIAZINE
DB07551 2-CHLORO-4-ETHYLAMINO-6-(S(-)-2'-CYANO-4-BUTYLAMINO)-1,3,5-TRIAZINE
DB07552 2-CHLORO-4-ETHYLAMINO-6-(R(+)-2'-CYANO-4-BUTYLAMINO)-1,3,5-TRIAZINE
DB07667 2-((3',5'-DIMETHYL-4'-HYDROXYPHENYL)AZO)BENZOIC ACID
DB07752 FARNESYL
DB07780 FARNESYL DIPHOSPHATE
DB07841 GERANYLGERANYL DIPHOSPHATE
DB07880 2-((4'-HYDROXYPHENYL)-AZO)BENZOIC ACID
DB08181 2-((3'-METHYL-4'-HYDROXYPHENYL)AZO)BENZOIC ACID
DB08196 2-((3',5'-DIMETHOXY-4'-HYDROXYPHENYL)AZO)BENZOIC ACID
DB08215 2-T-BUTYLAMINO-4-ETHYLAMINO-6-METHYLTHIO-S-TRIAZINE
DB08216 2-((3'-TERTBUTYL-4'-HYDROXYPHENYL)AZO)BENZOIC ACID
DB08252 2-((4'-HYDROXYNAPHTHYL)-AZO)BENZOIC ACID
DB08596 5'-deoxy-5'-piperidin-1-ylthymidine
DB08661 1-(2,5-dideoxy-5-pyrrolidin-1-yl-beta-L-erythro-pentofuranosyl)-5-methylpyrimidine-2,4(1H,3H)-dione
DB08689 UBIQUINONE-1
DB08690 UBIQUINONE-2
DB08813 Nadroparin
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