DT-Web

DB01225 - Enoxaparin


Identification
Name Enoxaparin
Accession Number DB01225 (APRD00068)
Type small molecule
Description Enoxaparin is a low molecular weight heparin. Enoxaparin is used to prevent and treat deep vein thrombosis or pulmonary embolism, and is given as a subcutaneous injection. Enoxaparin binds to and accelerates the activity of antithrombin III. By activating antithrombin III, enoxaparin preferentially potentiates the inhibition of coagulation factors Xa and IIa. Factor Xa catalyzes the conversion of prothrombin to thrombin, so enoxaparin's inhibition of this process results in decreased thrombin and ultimately the prevention of fibrin clot formation. Low molecular weight heparins are less effective at inactivating factor IIa due to their shorter length compared to unfractionated heparin.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 1134.928
Groups approved
Monoisotopic Weight 1134.006993818
Pharmacology
Indication For the prophylaxis of deep vein thrombosis, which may lead to pulmonary embolism, and also for the prophylaxis of ischemic complications of unstable angina and non-Q-wave myocardial infarction, when concurrently administered with aspirin.
Mechanism of action The mechanism of action of enoxaparin is antithrombin-dependent. It acts mainly by accelerating the rate of the neutralization of certain activated coagulation factors by antithrombin, but other mechanisms may also be involved. The antithrombotic effect of enoxaparin is well correlated to the inhibition of factor Xa. Enoxaparin interacts with Antithrombin III, Prothrombin and Factor X. Enoxaparin binds to and accelerates the activity of antithrombin III. By activating antithrombin III, enoxaparin preferentially potentiates the inhibition of coagulation factors Xa and IIa.
Absorption Mean absolute bioavailability of enoxaparin, after 1.5 mg/kg given subcutaneously, based on anti-Factor Xa activity is approximately 100% in healthy volunteers.
Protein binding 80% bound-albumin
Biotransformation Undergoes desulfation and polymerization via the liver
Route of elimination Enoxaparin sodium is primarily metabolized in the liver by desulfation and/or depolymerization to lower molecular weight species with much reduced biological potency. Renal clearance of active fragments represents about 10% of the administered dose and total renal excretion of active and non-active fragments 40% of the dose.
Toxicity Mouse, median lethal dose greater than 5000 mg/kg. Another side effect is heparin induced thrombocytopenia (HIT syndrome). HIT is caused by an immunological reaction that makes platelets form clots within the blood vessels, thereby using up coagulation factors.
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Apixaban Due to pharmacodynamic interaction, a 50-60% increase in anti-Factor Xa activity may be observed with concomitant therapy.
Drotrecogin alfa Combination should be used with caution after weighing advantages and disadvantages. Low molecular weight heparins such as enoxaparin may increase the adverse effects of drotrecogin. Monitor for bleeding if used concomitantly.
Ginkgo biloba Additive anticoagulant/antiplatelet effects may increase bleed risk. Concomitant therapy should be avoided.
Treprostinil The prostacyclin analogue, Treprostinil, increases the risk of bleeding when combined with the anticoagulant, Exoxaparin. Monitor for increased bleeding during concomitant thearpy.
Food Interactions
  • Avoid danshen, dong quai, evening primrose oil, gingko, policosanol, willow bark

Targets


Antithrombin-III
Name Antithrombin-III
Gene Name SERPINC1
Pharmacological action yes
Actions potentiator
References
  • Peng K, Wang C, Pang BS, Yang YH: [Effects of thrombolysis and anticoagulation on the functions of vascular endothelial cells and coagulation and fibrinolysis in patients with pulmonary thromboembolism] Zhonghua Jie He He Hu Xi Za Zhi. 2005 Sep;28(9):596-9. - Pubmed
  • Lee S, Gibson CM: Enoxaparin in acute coronary syndromes. Expert Rev Cardiovasc Ther. 2007 May;5(3):387-99. - Pubmed
  • Bisio A, Vecchietti D, Citterio L, Guerrini M, Raman R, Bertini S, Eisele G, Naggi A, Sasisekharan R, Torri G: Structural features of low-molecular-weight heparins affecting their affinity to antithrombin. Thromb Haemost. 2009 Nov;102(5):865-73. - Pubmed
DTHybrid score 0.6532
Coagulation factor X
Name Coagulation factor X
Gene Name F10
Pharmacological action yes
Actions inhibitor
References
  • Graff J, Picard-Willems B, Harder S: Monitoring effects of direct FXa-inhibitors with a new one-step prothrombinase-induced clotting time (PiCT) assay: comparative in vitro investigation with heparin, enoxaparin, fondaparinux and DX 9065a. Int J Clin Pharmacol Ther. 2007 Apr;45(4):237-43. - Pubmed
  • Berges A, Laporte S, Epinat M, Zufferey P, Alamartine E, Tranchand B, Decousus H, Mismetti P: Anti-factor Xa activity of enoxaparin administered at prophylactic dosage to patients over 75 years old. Br J Clin Pharmacol. 2007 Oct;64(4):428-38. Epub 2007 May 17. - Pubmed
  • Sanchez-Pena P, Hulot JS, Urien S, Ankri A, Collet JP, Choussat R, Lechat P, Montalescot G: Anti-factor Xa kinetics after intravenous enoxaparin in patients undergoing percutaneous coronary intervention: a population model analysis. Br J Clin Pharmacol. 2005 Oct;60(4):364-73. - Pubmed
  • Dalmora SL, Junior LB, Schmidt CA, Vaccari SF, Oliveira PR, Codevilla CF: Validation of the anti-factor Xa assay for the potency assessment of enoxaparin in pharmaceutical formulations. J AOAC Int. 2004 Nov-Dec;87(6):1305-8. - Pubmed
  • Paige JT, Gouda BP, Gaitor-Stampley V, Scalia PG, Klainer TE, Raum WJ, Martin LF: No correlation between anti-factor Xa levels, low-molecular-weight heparin, and bleeding after gastric bypass. Surg Obes Relat Dis. 2007 Jul-Aug;3(4):469-75. Epub 2007 Jun 12. - Pubmed
DTHybrid score 1.5664

Enzymes


Myeloperoxidase
Name Myeloperoxidase
Gene Name MPO
Actions Other
References
  • Rudolph TK, Rudolph V, Witte A, Klinke A, Szoecs K, Lau D, Heitzer T, Meinertz T, Baldus S: Liberation of vessel adherent myeloperoxidase by enoxaparin improves endothelial function. Int J Cardiol. 2010 Apr 1;140(1):42-7. Epub 2008 Dec 2. - Pubmed
DTHybrid score 0.3544

Predictions


Id Partner name Gene Name Score
852 Heparin cofactor 2 SERPIND1 0.2155
2058 P-selectin SELP 0.167
1719 Heparanase HPSE 0.1183
54 Prothrombin F2 0.0905
2020 Stromal cell-derived factor 1 CXCL12 0.0902
1953 Proto-oncogene protein c-fos FOS 0.09
647 Integrin alpha-4 ITGA4 0.0783
1334 Tissue factor pathway inhibitor TFPI 0.0602
290 Prostaglandin G/H synthase 2 PTGS2 0.0391
1736 Somatostatin SST 0.0311
4186 Neuropeptide Y receptor type 2 NPY2R 0.0311
183 Vascular endothelial growth factor A VEGFA 0.0304
20 Prostaglandin G/H synthase 1 PTGS1 0.0281
3997 Cytochrome P450 24A1, mitochondrial CYP24A1 0.0239
563 Thyroid peroxidase TPO 0.0238
153 Dopamine beta-hydroxylase DBH 0.0238
275 Arachidonate 5-lipoxygenase ALOX5 0.0215
503 Somatostatin receptor type 1 SSTR1 0.0214
723 Cytosolic phospholipase A2 PLA2G4A 0.021
3866 Serum amyloid A protein SAA1 0.0209
1932 Apolipoprotein E APOE 0.0208
1200 AMBP protein AMBP 0.0208
6020 Aldehyde oxidase AOX1 0.0206
61 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0201
2644 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0201
2710 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0201
3872 Somatostatin receptor type 5 SSTR5 0.02
6008 Somatostatin receptor type 2 SSTR2 0.02
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.019
856 Vitamin D3 receptor VDR 0.0189
369 Coagulation factor VII F7 0.0188
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0183
4200 Cytochrome P450 1A2 CYP1A2 0.0177
448 Vitamin K-dependent gamma-carboxylase GGCX 0.0177
798 Osteocalcin BGLAP 0.0167
3831 Low-density lipoprotein receptor-related protein 1 LRP1 0.016
115 Penicillin-binding protein 2 mrdA 0.016
6069 Penicillin-binding protein 2 mrdA 0.016
6118 Penicillin-binding protein 2 penA 0.016
6187 Penicillin-binding protein 2 pbpA 0.016
6686 Penicillin-binding protein 2 pbp2 0.016
6939 Penicillin-binding protein 2 mrdA 0.016
7163 Penicillin-binding protein 2 pbpA 0.016
867 Penicillin-binding protein 3 pbpC 0.016
6119 Penicillin-binding protein 3 pbp3 0.016
7154 Penicillin-binding protein 3 pbp3 0.016
7157 Penicillin-binding protein 3 LMHCC_2184 0.016
7162 Penicillin-binding protein 3 pbpB 0.016
7172 Penicillin-binding protein 3 pbp3 0.016
6012 Tryptophan 2,3-dioxygenase TDO2 0.0155
4757 Cytochrome P450 2C9 CYP2C9 0.0153
6182 Cytochrome P450 2J2 CYP2J2 0.0145
6165 Copper-transporting ATPase 1 ATP7A 0.0132
6163 Copper-transporting ATPase 2 ATP7B 0.0132
633 Penicillin-binding proteins 1A/1B pbpA 0.0132
6146 High affinity copper uptake protein 1 SLC31A1 0.0125
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0121
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0121
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.012
908 Glutathione S-transferase theta-1 GSTT1 0.0119
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0119
3947 Xanthine dehydrogenase/oxidase XDH 0.0117
19 Coagulation factor VIII F8 0.0113
2139 Tissue factor F3 0.0111
3830 Calreticulin CALR 0.0107
896 Glutathione S-transferase Mu 1 GSTM1 0.0105
118 Organic cation/carnitine transporter 2 SLC22A5 0.0103
3851 Serine protease hepsin HPN 0.01
4512 Cytochrome P450 3A4 CYP3A4 0.0098
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0098
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0097
904 Glutathione S-transferase P GSTP1 0.0094
6016 Cytochrome P450 2C19 CYP2C19 0.0092
6024 Cytochrome P450 1A1 CYP1A1 0.0091
6013 Cytochrome P450 2E1 CYP2E1 0.009
4118 Cytochrome P450 3A5 CYP3A5 0.009
400 Coagulation factor IX F9 0.0084
5461 Coagulation factor IX F9 0.0084
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0083
1547 Coagulation factor XI F11 0.0081
713 Sodium-dependent dopamine transporter SLC6A3 0.008
3941 Amine oxidase [flavin-containing] A MAOA 0.008
238 Peroxisome proliferator-activated receptor gamma PPARG 0.008
3939 Amine oxidase [flavin-containing] B MAOB 0.008
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0076
1588 Multidrug resistance protein 1 ABCB1 0.0076
4924 Cytochrome P450 2C8 CYP2C8 0.0076
1729 Solute carrier family 22 member 6 SLC22A6 0.0075
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0075
422 Vitamin K-dependent protein C PROC 0.0071
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0071
3842 Multiple coagulation factor deficiency protein 2 MCFD2 0.007
3841 ERGIC-53 protein LMAN1 0.007
3840 Asialoglycoprotein receptor 2 ASGR2 0.007
1847 78 kDa glucose-regulated protein HSPA5 0.007
1635 von Willebrand factor VWF 0.007
109 Mitochondrial carnitine/acylcarnitine carrier protein CACL SLC25A29 0.0067
636 Mitochondrial carnitine/acylcarnitine carrier protein SLC25A20 0.0067
3601 Dihydropteroate synthase 1 folP1 0.0065
3807 Dihydropteroate synthase 1 folP1 0.0065
3808 Dihydropteroate synthase 2 folP2 0.0065
122 P2Y purinoceptor 12 P2RY12 0.0062
1516 Calnexin CANX 0.0061
6036 Eosinophil peroxidase EPX 0.0059
6168 Solute carrier family 22 member 16 SLC22A16 0.0058
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0058
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0058
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0057
412 Peroxisomal carnitine O-octanoyltransferase CROT 0.0057
551 Carnitine O-acetyltransferase CRAT 0.0057
6589 Delta-hemolysin hld 0.0056
6424 Light-harvesting protein B-800/820 beta chain Not Available 0.0056
6591 ATP synthase C chain atpH 0.0056
6587 Rubredoxin rub 0.0056
6423 Light-harvesting protein B-800/820 alpha chain Not Available 0.0056
6586 Protein S100-G S100G 0.0056
6588 Methionyl-tRNA formyltransferase fmt 0.0056
4718 Putative ATP-dependent Clp protease proteolytic subunit, mitochondrial CLPP 0.0056
6592 Probable L-ascorbate-6-phosphate lactonase ulaG ulaG 0.0056
6585 HLA class I histocompatibility antigen, B-27 alpha chain HLA-B 0.0056
6593 Immunoglobulin G-binding protein G spg 0.0056
4604 Liver carboxylesterase 1 CES1 0.0055
6034 Hydroxyindole O-methyltransferase ASMT 0.0055
6035 Nuclear receptor ROR-beta RORB 0.0055
1898 Cytochrome P450 1B1 CYP1B1 0.0053
3175 Glutamate--cysteine ligase gshA 0.0053
6142 Solute carrier family 22 member 8 SLC22A8 0.0051
6030 Cytochrome P450 2B6 CYP2B6 0.0049
3839 Phytanoyl-CoA dioxygenase, peroxisomal PHYH 0.0049
6495 Cytochrome c oxidase subunit 7C, mitochondrial COX7C 0.0049
6493 Cytochrome c oxidase subunit 6C COX6C 0.0048
6498 Cytochrome c oxidase subunit 6B1 COX6B1 0.0048
6279 Beta-2-microglobulin B2M 0.0048
6497 Cytochrome c oxidase subunit 6A2, mitochondrial COX6A2 0.0048
6496 Cytochrome c oxidase subunit 8A, mitochondrial COX8A 0.0048
6499 Cytochrome c oxidase polypeptide 7A1, mitochondrial COX7A1 0.0048
6494 Cytochrome c oxidase subunit 7B, mitochondrial COX7B 0.0048
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.0048
6559 Cytochrome c oxidase subunit 2 ctaC 0.0048
6669 Cytochrome c oxidase subunit 2 ctaC 0.0048
6490 Cytochrome c oxidase subunit 3 MT-CO3 0.0048
6491 Cytochrome c oxidase subunit 5A, mitochondrial COX5A 0.0048
6489 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial COX4I1 0.0048
371 Cytochrome c oxidase subunit 1 MT-CO1 0.0048
6558 Cytochrome c oxidase subunit 1 ctaD 0.0048
6319 Respiratory nitrate reductase 1 gamma chain narI 0.0048
6318 Respiratory nitrate reductase 1 beta chain narH 0.0048
6317 Respiratory nitrate reductase 1 alpha chain narG 0.0048
765 Indoleamine 2,3-dioxygenase IDO1 0.0047
6102 Arylamine N-acetyltransferase 2 NAT2 0.0045
362 Melatonin receptor type 1B MTNR1B 0.0045
571 Melatonin receptor type 1A MTNR1A 0.0045
6428 Light-harvesting protein B-800/850 beta chain Not Available 0.0045
6427 Light-harvesting protein B-800/850 alpha chain Not Available 0.0045
6533 Light-harvesting protein B-800/850 alpha chain A1 0.0045
6144 Solute carrier family 22 member 2 SLC22A2 0.0042
6576 Geranylgeranyl transferase type-2 subunit beta RABGGTB 0.0042
6575 Geranylgeranyl transferase type-2 subunit alpha RABGGTA 0.0042
2132 Protein S100-B S100B 0.0041
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0041
4878 Glycoprotein hormones alpha chain CGA 0.0041
4856 CD209 antigen CD209 0.0041
1052 Cytotoxic T-lymphocyte protein 4 CTLA4 0.0041
1072 Granzyme B GZMB 0.0041
4871 Endo-beta-N-acetylglucosaminidase F3 endOF3 0.0041
4850 Beta-2-glycoprotein 1 APOH 0.0041
4880 Membrane cofactor protein CD46 0.0041
4889 Ig epsilon chain C region IGHE 0.0041
4189 Alpha-galactosidase A GLA 0.0041
4869 Major capsid protein A430L 0.0041
4852 Reticulon-4 receptor RTN4R 0.0041
4877 Beta-mannanase man 0.0041
442 Envelope glycoprotein gp41 0.0041
4859 Envelope glycoprotein env 0.0041
4845 ADAM 33 ADAM33 0.0041
757 Fusion glycoprotein F0 F 0.0041
4875 Fusion glycoprotein F0 F 0.0041
1563 Platelet glycoprotein Ib alpha chain GP1BA 0.0041
1354 Beta-glucuronidase GUSB 0.0041
4882 Dipeptidyl aminopeptidase-like protein 6 DPP6 0.0041
4721 Beta-1,4-mannanase manA 0.0041
3352 Structural polyprotein Not Available 0.0041
3628 Structural polyprotein Not Available 0.0041
4892 Structural polyprotein Not Available 0.0041
6352 Reaction center protein H chain puhA 0.0036
6456 Reaction center protein H chain puhA 0.0036
6682 Reaction center protein H chain puhA 0.0036
6353 Reaction center protein L chain pufL 0.0036
6454 Reaction center protein L chain pufL 0.0036
6683 Reaction center protein L chain pufL 0.0036
6351 Photosynthetic reaction center cytochrome c subunit pufC 0.0036
6354 Reaction center protein M chain pufM 0.0036
6455 Reaction center protein M chain pufM 0.0036
6684 Reaction center protein M chain pufM 0.0036
793 T-cell surface antigen CD2 CD2 0.0036
119 Carcinoembryonic antigen-related cell adhesion molecule 1 CEACAM1 0.0036
4861 Interleukin-6 receptor alpha chain IL6R 0.0036
4193 Atrial natriuretic peptide clearance receptor NPR3 0.0036
3837 Cytokine receptor common beta chain CSF2RB 0.0036
833 Organic cation/carnitine transporter 1 SLC22A4 0.0035
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0035
1184 Interferon beta IFNB1 0.0033
4857 Zinc-alpha-2-glycoprotein AZGP1 0.0033
6106 Cytochrome P450 2C18 CYP2C18 0.0033
3923 Cholinesterase BCHE 0.0033
1379 Interleukin-12 subunit beta IL12B 0.0033
6858 Inactive carboxylesterase 4 CES1P1 0.0033
4890 Hemagglutinin HA 0.0033
6566 Hemagglutinin Not Available 0.0033
3027 Streptavidin Not Available 0.0032
554 Low-density lipoprotein receptor LDLR 0.0032
2998 Sialic acid-binding Ig-like lectin 7 SIGLEC7 0.0031
6120 Cation-independent mannose-6-phosphate receptor IGF2R 0.0031
2297 Genome polyprotein Not Available 0.0031
2322 Genome polyprotein Not Available 0.0031
2694 Genome polyprotein Not Available 0.0031
2719 Genome polyprotein Not Available 0.0031
2860 Genome polyprotein Not Available 0.0031
2928 Genome polyprotein Not Available 0.0031
3160 Genome polyprotein Not Available 0.0031
3260 Genome polyprotein Not Available 0.0031
4783 Genome polyprotein Not Available 0.0031
5726 Genome polyprotein Not Available 0.0031
5779 Genome polyprotein Not Available 0.0031
5867 Genome polyprotein Not Available 0.0031
6253 Genome polyprotein Not Available 0.0031
6301 Genome polyprotein Not Available 0.0031
6380 Genome polyprotein Not Available 0.0031
6381 Genome polyprotein Not Available 0.0031
6437 Genome polyprotein Not Available 0.0031
6520 Genome polyprotein Not Available 0.0031
6521 Genome polyprotein Not Available 0.0031
6652 Genome polyprotein Not Available 0.0031
6734 Genome polyprotein Not Available 0.0031
6735 Genome polyprotein Not Available 0.0031
6736 Genome polyprotein Not Available 0.0031
6737 Genome polyprotein Not Available 0.0031
6738 Genome polyprotein Not Available 0.0031
6739 Genome polyprotein Not Available 0.0031
6744 Genome polyprotein Not Available 0.0031
6748 Genome polyprotein Not Available 0.0031
6894 Genome polyprotein Not Available 0.0031
6898 Genome polyprotein Not Available 0.0031
18 High affinity immunoglobulin epsilon receptor subunit alpha FCER1A 0.0031
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.003
604 Vitamin K-dependent protein Z PROZ 0.003
4081 Vitamin K epoxide reductase complex subunit 1-like protein 1 VKORC1L1 0.003
3444 Cyanovirin-N Not Available 0.003
3140 Hemagglutinin-neuraminidase HN 0.003
3609 Hemagglutinin-neuraminidase HN 0.003
3258 Mannosyl-oligosaccharide alpha-1,2-mannosidase MSDC 0.003
1859 Prostatic acid phosphatase ACPP 0.0029
465 Calmodulin CALM1 0.0029
4787 Envelope glycoprotein gp160 env 0.0029
4820 Envelope glycoprotein gp160 env 0.0029
5727 Envelope glycoprotein gp160 env 0.0029
5682 Ribonuclease pancreatic RNASE1 0.0029
1245 Vitamin K-dependent protein S PROS1 0.0028
4119 Cytochrome P450 2D6 CYP2D6 0.0028
4666 Fucose-binding lectin PA-IIL lecB 0.0028
595 Fibrinogen alpha chain FGA 0.0028
2372 Bifunctional tail protein 9 0.0028
6147 Solute carrier family 22 member 3 SLC22A3 0.0027
2577 Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase MAN1B1 0.0026
468 Cytochrome P450 4A11 CYP4A11 0.0026
6137 Multidrug resistance-associated protein 6 ABCC6 0.0026
3480 Mannan endo-1,4-beta-mannosidase manA 0.0026
3811 Cytochrome P450 19A1 CYP19A1 0.0026
958 Insulin-like growth factor 1 receptor IGF1R 0.0025
64 Neuraminidase NA 0.0025
641 Neuraminidase NA 0.0025
2676 Neuraminidase NA 0.0025
3026 Neuraminidase NA 0.0025
3519 Neuraminidase NA 0.0025
6007 Neuraminidase NA 0.0025
1243 Cathepsin D CTSD 0.0024
6107 Cytochrome P450 3A7 CYP3A7 0.0024
136 Estrogen receptor ESR1 0.0024
1439 Lactotransferrin LTF 0.0024
1782 Neutrophil gelatinase-associated lipocalin LCN2 0.0024
6136 Multidrug resistance-associated protein 5 ABCC5 0.0024
2430 Chondroitinase B cslB 0.0023
3814 Complement C1r subcomponent C1R 0.0023
6145 Solute carrier family 22 member 1 SLC22A1 0.0023
2581 Chondroitinase AC cslA 0.0022
6847 Lactase-phlorizin hydrolase LCT 0.0022
6307 Ig gamma-2 chain C region IGHG2 0.0022
6500 Phospholipase A2 PLA2G1B 0.0021
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0021
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0021
2207 Rhodopsin RHO 0.0021
3917 Methylenetetrahydrofolate reductase MTHFR 0.0019
4785 Ig gamma-1 chain C region IGHG1 0.0018
76 Nitric-oxide synthase, brain NOS1 0.0018
952 Dipeptidyl peptidase 4 DPP4 0.0016
5718 Cytochrome P450 2A6 CYP2A6 0.0013
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