DT-Web: DB00157

Identification
Name	NADH
Accession Number	DB00157 (NUTR00041)
Type	small molecule
Description	NADH is the reduced form of NAD+, and NAD+ is the oxidized form of NADH, A coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH). It forms NADP with the addition of a phosphate group to the 2' position of the adenosyl nucleotide through an ester linkage.(Dorland, 27th ed)
Structure	MOL SDF PDB SMILES InChI
Categories ^(*)	Dietary supplement Micronutrient
Molecular Weight	665.441
Groups	approved
Monoisotopic Weight	665.124771695
Pharmacology
Indication	Some evidence suggests that NADH might be useful in treating Parkinson's disease, chronic fatigue syndrome, Alzheimer's disease and cardiovascular disease.
Mechanism of action	NADH is synthesized by the body and thus is not an essential nutrient. It does require the essential nutrient nicotinamide for its synthesis, and its role in energy production is certainly an essential one. In addition to its role in the mitochondrial electron transport chain, NADH is produced in the cytosol. The mitochondrial membrane is impermeable to NADH, and this permeability barrier effectively separates the cytoplasmic from the mitochondrial NADH pools. However, cytoplasmic NADH can be used for biologic energy production. This occurs when the malate-aspartate shuttle introduces reducing equivalents from NADH in the cytosol to the electron transport chain of the mitochondria. This shuttle mainly occurs in the liver and heart.
Absorption	Unclear how much of an administered dose is absorbed.
Protein binding	Not Available
Biotransformation	Not Available
Route of elimination	Not Available
Toxicity	No reports of overdose, however, high doses of NADH (10 mg a day or more) may cause jitteriness, anxiety, and insomnia.
Affected organisms	Humans and other mammals
Interactions
Drug Interactions	Not Available
Food Interactions	Not Available

UDP-glucose 6-dehydrogenase
Name	UDP-glucose 6-dehydrogenase
Gene Name	UGDH
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed Castellani AA, De Luca G, Rindi S, Salvini R, Tira ME: Regulatory mechanisms of UDP-glucuronic acid biosynthesis in cultured human skin fibroblasts. Ital J Biochem. 1986 Sep-Oct;35(5):296-303. - Pubmed Alary J, Cravedi JP, Baradat M, Carrera G: Mechanism of cadmium-decreased glucuronidation in the rat. Biochem Pharmacol. 1992 Dec 1;44(11):2139-47. - Pubmed
DTHybrid score	1.1017
Alcohol dehydrogenase 1A
Name	Alcohol dehydrogenase 1A
Gene Name	ADH1A
Pharmacological action	unknown
Actions	Not Available
References	Bieganowski P, Seidle HF, Wojcik M, Brenner C: Synthetic lethal and biochemical analyses of NAD and NADH kinases in Saccharomyces cerevisiae establish separation of cellular functions. J Biol Chem. 2006 Aug 11;281(32):22439-45. Epub 2006 Jun 7. - Pubmed Manriquez D, El-Sharkawy I, Flores FB, El-Yahyaoui F, Regad F, Bouzayen M, Latche A, Pech JC: Two highly divergent alcohol dehydrogenases of melon exhibit fruit ripening-specific expression and distinct biochemical characteristics. Plant Mol Biol. 2006 Jul;61(4-5):675-85. - Pubmed
DTHybrid score	1.2341
Sorbitol dehydrogenase
Name	Sorbitol dehydrogenase
Gene Name	SORD
Pharmacological action	unknown
Actions	Not Available
References	Ido Y: Pyridine nucleotide redox abnormalities in diabetes. Antioxid Redox Signal. 2007 Jul;9(7):931-42. - Pubmed Klimacek M, Hellmer H, Nidetzky B: Catalytic mechanism of Zn2+-dependent polyol dehydrogenases: kinetic comparison of sheep liver sorbitol dehydrogenase with wild-type and Glu154-->Cys forms of yeast xylitol dehydrogenase. Biochem J. 2007 Jun 15;404(3):421-9. - Pubmed
DTHybrid score	1.5125
Alcohol dehydrogenase 4
Name	Alcohol dehydrogenase 4
Gene Name	ADH4
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed Thielen J, Ciriacy M: Biochemical basis of mitochondrial acetaldehyde dismutation in Saccharomyces cerevisiae. J Bacteriol. 1991 Nov;173(21):7012-7. - Pubmed Plapp BV, Mitchell JL, Berst KB: Mouse alcohol dehydrogenase 4: kinetic mechanism, substrate specificity and simulation of effects of ethanol on retinoid metabolism. Chem Biol Interact. 2001 Jan 30;130-132(1-3):445-56. - Pubmed Widenius TV: Ethanol-induced inhibition of testosterone biosynthesis in vitro: lack of acetaldehyde effect. Alcohol Alcohol. 1987;22(1):17-22. - Pubmed
DTHybrid score	1.2564
Alcohol dehydrogenase 1C
Name	Alcohol dehydrogenase 1C
Gene Name	ADH1C
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed Plapp BV, Berst KB: Specificity of human alcohol dehydrogenase 1C*2 (gamma2gamma2) for steroids and simulation of the uncompetitive inhibition of ethanol metabolism. Chem Biol Interact. 2003 Feb 1;143-144:183-93. - Pubmed
DTHybrid score	2.0804
Alcohol dehydrogenase 1B
Name	Alcohol dehydrogenase 1B
Gene Name	ADH1B
Pharmacological action	unknown
Actions	Not Available
References	Manriquez D, El-Sharkawy I, Flores FB, El-Yahyaoui F, Regad F, Bouzayen M, Latche A, Pech JC: Two highly divergent alcohol dehydrogenases of melon exhibit fruit ripening-specific expression and distinct biochemical characteristics. Plant Mol Biol. 2006 Jul;61(4-5):675-85. - Pubmed
DTHybrid score	1.4443
Alcohol dehydrogenase class 4 mu/sigma chain
Name	Alcohol dehydrogenase class 4 mu/sigma chain
Gene Name	ADH7
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed Dalfo D, Marques N, Albalat R: Analysis of the NADH-dependent retinaldehyde reductase activity of amphioxus retinol dehydrogenase enzymes enhances our understanding of the evolution of the retinol dehydrogenase family. FEBS J. 2007 Jul;274(14):3739-52. Epub 2007 Jul 2. - Pubmed Suzuki Y, Ishiguro S, Tamai M: Identification and immunohistochemistry of retinol dehydrogenase from bovine retinal pigment epithelium. Biochim Biophys Acta. 1993 May 13;1163(2):201-8. - Pubmed Kim DS, Lee CB, Park YS, Ahn YH, Kim TW, Kee CS, Kang JS, Om AS: Effect of thyroid hormone on the alcohol dehydrogenase activities in rat tissues. J Korean Med Sci. 2001 Jun;16(3):313-6. - Pubmed
DTHybrid score	1.089
Glycerol-3-phosphate dehydrogenase [NAD+], cytoplasmic
Name	Glycerol-3-phosphate dehydrogenase [NAD+], cytoplasmic
Gene Name	GPD1
Pharmacological action	unknown
Actions	Not Available
References	Fonvielle M, Therisod H, Hemery M, Therisod M: New competitive inhibitors of cytosolic (NADH-dependent) rabbit muscle glycerophosphate dehydrogenase. Bioorg Med Chem Lett. 2007 Jan 15;17(2):410-3. Epub 2006 Oct 17. - Pubmed
DTHybrid score	1.102
L-lactate dehydrogenase A-like 6A
Name	L-lactate dehydrogenase A-like 6A
Gene Name	LDHAL6A
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score	1.1039
Alcohol dehydrogenase class 3
Name	Alcohol dehydrogenase class 3
Gene Name	ADH5
Pharmacological action	unknown
Actions	Not Available
References	Schirwitz K, Schmidt A, Lamzin VS: High-resolution structures of formate dehydrogenase from Candida boidinii. Protein Sci. 2007 Jun;16(6):1146-56. - Pubmed Baumchen C, Roth AH, Biedendieck R, Malten M, Follmann M, Sahm H, Bringer-Meyer S, Jahn D: D-Mannitol production by resting state whole cell biotransformation of D-fructose by heterologous mannitol and formate dehydrogenase gene expression in Bacillus megaterium. Biotechnol J. 2007 Jul 9;. - Pubmed Okochi M, Nakagawa I, Kobayashi T, Hayashi S, Furusaki S, Honda H: Enhanced activity of 3alpha-hydroxysteroid dehydrogenase by addition of the co-solvent 1-butyl-3-methylimidazolium (L)-lactate in aqueous phase of biphasic systems for reductive production of steroids. J Biotechnol. 2007 Feb 1;128(2):376-82. Epub 2006 Oct 12. - Pubmed Baron R, Lioubashevski O, Katz E, Niazov T, Willner I: Logic gates and elementary computing by enzymes. J Phys Chem A. 2006 Jul 13;110(27):8548-53. - Pubmed
DTHybrid score	1.7082
Aldose reductase
Name	Aldose reductase
Gene Name	AKR1B1
Pharmacological action	unknown
Actions	Not Available
References	Ido Y: Pyridine nucleotide redox abnormalities in diabetes. Antioxid Redox Signal. 2007 Jul;9(7):931-42. - Pubmed Linster CL, Van Schaftingen E: Vitamin C. Biosynthesis, recycling and degradation in mammals. FEBS J. 2007 Jan;274(1):1-22. - Pubmed
DTHybrid score	1.991
3-hydroxyacyl-CoA dehydrogenase type-2
Name	3-hydroxyacyl-CoA dehydrogenase type-2
Gene Name	HSD17B10
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score	1.606
Malate dehydrogenase, mitochondrial
Name	Malate dehydrogenase, mitochondrial
Gene Name	MDH2
Pharmacological action	unknown
Actions	Not Available
References	Baumchen C, Roth AH, Biedendieck R, Malten M, Follmann M, Sahm H, Bringer-Meyer S, Jahn D: D-Mannitol production by resting state whole cell biotransformation of D-fructose by heterologous mannitol and formate dehydrogenase gene expression in Bacillus megaterium. Biotechnol J. 2007 Jul 9;. - Pubmed Gallarta F, Sainz FJ, Saenz C: Fluorescent sensing layer for the determination of L-malic acid in wine. Anal Bioanal Chem. 2007 Mar;387(6):2297-305. Epub 2007 Jan 4. - Pubmed Markova EV, Zotova NV, Savchenko AA, Titova NM, Slepov EV, Cherdantsev DV, Konovalenko AN: [Lymphocyte metabolism in patients with acute pancreatitis with different genotypes of GSTM1 and GSTT1 genes] Biomed Khim. 2006 May-Jun;52(3):317-26. - Pubmed Yennaco LJ, Hu Y, Holden JF: Characterization of malate dehydrogenase from the hyperthermophilic archaeon Pyrobaculum islandicum. Extremophiles. 2007 Sep;11(5):741-6. Epub 2007 May 9. - Pubmed Rzem R, Vincent MF, Van Schaftingen E, Veiga-da-Cunha M: L: -2-Hydroxyglutaric aciduria, a defect of metabolite repair. J Inherit Metab Dis. 2007 Jun 21;. - Pubmed
DTHybrid score	0.8117
L-lactate dehydrogenase A chain
Name	L-lactate dehydrogenase A chain
Gene Name	LDHA
Pharmacological action	unknown
Actions	Not Available
References	Semenza GL: Oxygen-dependent regulation of mitochondrial respiration by hypoxia-inducible factor 1. Biochem J. 2007 Jul 1;405(1):1-9. - Pubmed Draghia AC: Histochemical and histopathological study of the gastric mucosa in the portal hypertensive gastropathy. Rom J Morphol Embryol. 2006;47(3):259-62. - Pubmed O'Brien J, Kla KM, Hopkins IB, Malecki EA, McKenna MC: Kinetic parameters and lactate dehydrogenase isozyme activities support possible lactate utilization by neurons. Neurochem Res. 2007 Apr-May;32(4-5):597-607. Epub 2006 Sep 28. - Pubmed
DTHybrid score	1.1176
NAD-dependent malic enzyme, mitochondrial
Name	NAD-dependent malic enzyme, mitochondrial
Gene Name	ME2
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score	1.5043
Peroxisomal multifunctional enzyme type 2
Name	Peroxisomal multifunctional enzyme type 2
Gene Name	HSD17B4
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed Haapalainen AM, Koski MK, Qin YM, Hiltunen JK, Glumoff T: Binary structure of the two-domain (3R)-hydroxyacyl-CoA dehydrogenase from rat peroxisomal multifunctional enzyme type 2 at 2.38 A resolution. Structure. 2003 Jan;11(1):87-97. - Pubmed
DTHybrid score	1.575
L-lactate dehydrogenase A-like 6B
Name	L-lactate dehydrogenase A-like 6B
Gene Name	LDHAL6B
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score	1.1038
L-lactate dehydrogenase C chain
Name	L-lactate dehydrogenase C chain
Gene Name	LDHC
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed Spielmann H, Eibs HG, Mentzel C: Rapid purification of lactate dehydrogenase X from mouse testes by two steps of affinity chromatography on oxamate-sepharose. Experientia. 1976 Aug 15;32(8):1085-6. - Pubmed Morris ID, Higgins C, Matlin SA: Inhibition of testicular LDH-X from laboratory animals and man by gossypol and its isomers. J Reprod Fertil. 1986 Jul;77(2):607-12. - Pubmed Gu Y, Davis DR, Lin YC: Developmental changes in lactate dehydrogenase-X activity in young jaundiced male rats. Arch Androl. 1989;22(2):131-6. - Pubmed
DTHybrid score	1.1035
L-lactate dehydrogenase B chain
Name	L-lactate dehydrogenase B chain
Gene Name	LDHB
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed Razeto A, Kochhar S, Hottinger H, Dauter M, Wilson KS, Lamzin VS: Domain closure, substrate specificity and catalysis of D-lactate dehydrogenase from Lactobacillus bulgaricus. J Mol Biol. 2002 Apr 19;318(1):109-19. - Pubmed Mdluli K, Booth MP, Brady RL, Rumsby G: A preliminary account of the properties of recombinant human Glyoxylate reductase (GRHPR), LDHA and LDHB with glyoxylate, and their potential roles in its metabolism. Biochim Biophys Acta. 2005 Dec 1;1753(2):209-16. Epub 2005 Aug 22. - Pubmed Clausen J: Lactate dehydrogenase isoenzymes of sperm cells and tests. Biochem J. 1969 Jan;111(2):207-18. - Pubmed
DTHybrid score	1.1452
Peroxisomal bifunctional enzyme
Name	Peroxisomal bifunctional enzyme
Gene Name	EHHADH
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score	1.1015
Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial
Name	Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial
Gene Name	HADH
Pharmacological action	unknown
Actions	Not Available
References	Norman JP, Perry SW, Kasischke KA, Volsky DJ, Gelbard HA: HIV-1 trans activator of transcription protein elicits mitochondrial hyperpolarization and respiratory deficit, with dysregulation of complex IV and nicotinamide adenine dinucleotide homeostasis in cortical neurons. J Immunol. 2007 Jan 15;178(2):869-76. - Pubmed
DTHybrid score	1.4769
NADP-dependent malic enzyme, mitochondrial
Name	NADP-dependent malic enzyme, mitochondrial
Gene Name	ME3
Pharmacological action	unknown
Actions	Not Available
References	Luo C, Wang X, Long J, Liu J: An NADH-tetrazolium-coupled sensitive assay for malate dehydrogenase in mitochondria and crude tissue homogenates. J Biochem Biophys Methods. 2006 Aug 31;68(2):101-11. Epub 2006 Apr 26. - Pubmed Wei H, Dhanaraj AL, Arora R, Rowland LJ, Fu Y, Sun L: Identification of cold acclimation-responsive Rhododendron genes for lipid metabolism, membrane transport and lignin biosynthesis: importance of moderately abundant ESTs in genomic studies. Plant Cell Environ. 2006 Apr;29(4):558-70. - Pubmed Rzem R, Vincent MF, Van Schaftingen E, Veiga-da-Cunha M: L: -2-Hydroxyglutaric aciduria, a defect of metabolite repair. J Inherit Metab Dis. 2007 Jun 21;. - Pubmed
DTHybrid score	1.3472
D-beta-hydroxybutyrate dehydrogenase, mitochondrial
Name	D-beta-hydroxybutyrate dehydrogenase, mitochondrial
Gene Name	BDH1
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed Tabata M, Totani M: A chemiluminescence-flow injection analysis of serum 3-hydroxybutyrate using a bioreactor consisting of 3-hydroxybutyrate dehydrogenase and NADH oxidase. Anal Biochem. 1995 Jul 20;229(1):133-8. - Pubmed Rudy B, Dubois H, Mink R, Trommer WE, McIntyre JO, Fleischer S: Coenzyme binding by 3-hydroxybutyrate dehydrogenase, a lipid-requiring enzyme: lecithin acts as an allosteric modulator to enhance the affinity for coenzyme. Biochemistry. 1989 Jun 27;28(13):5354-66. - Pubmed Smith CM, Plaut GW: Activities of NAD-specific and NADP-specific isocitrate dehydrogenases in rat-liver mitochondria. Studies with D-threo-alpha-methylisocitrate. Eur J Biochem. 1979 Jun;97(1):283-95. - Pubmed
DTHybrid score	1.1022
Malate dehydrogenase, cytoplasmic
Name	Malate dehydrogenase, cytoplasmic
Gene Name	MDH1
Pharmacological action	unknown
Actions	Not Available
References	Drew DP, Lunde C, Lahnstein J, Fincher GB: Heterologous expression of cDNAs encoding monodehydroascorbate reductases from the moss, Physcomitrella patens and characterization of the expressed enzymes. Planta. 2007 Mar;225(4):945-54. - Pubmed
DTHybrid score	1.0491
3-hydroxyisobutyrate dehydrogenase, mitochondrial
Name	3-hydroxyisobutyrate dehydrogenase, mitochondrial
Gene Name	HIBADH
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score	1.1021
Estradiol 17-beta-dehydrogenase 3
Name	Estradiol 17-beta-dehydrogenase 3
Gene Name	HSD17B3
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed Inano H, Tamaoki B: Relationship between steroids and pyridine nucleotides in the oxido-reduction catalyzed by the 17 beta-hydroxysteroid dehydrogenase purified from the porcine testicular microsomal fraction. Eur J Biochem. 1975 May 6;53(2):319-26. - Pubmed
DTHybrid score	1.1022
3-hydroxy-3-methylglutaryl-coenzyme A reductase
Name	3-hydroxy-3-methylglutaryl-coenzyme A reductase
Gene Name	HMGCR
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed Huber R, Riepe MW: Improved posthypoxic recovery in vitro on treatment with drugs used for secondary stroke prevention. Neuropharmacology. 2005 Mar;48(4):558-65. - Pubmed Hedl M, Rodwell VW: Inhibition of the class II HMG-CoA reductase of Pseudomonas mevalonii. Protein Sci. 2004 Jun;13(6):1693-7. - Pubmed Li S, Wagner CA, Friesen JA, Borst DW: 3-hydroxy-3-methylglutaryl-coenzyme A reductase in the lobster mandibular organ: regulation by the eyestalk. Gen Comp Endocrinol. 2003 Nov;134(2):147-55. - Pubmed
DTHybrid score	0.8699
NADP-dependent malic enzyme
Name	NADP-dependent malic enzyme
Gene Name	ME1
Pharmacological action	unknown
Actions	Not Available
References	McKinlay JB, Shachar-Hill Y, Zeikus JG, Vieille C: Determining Actinobacillus succinogenes metabolic pathways and fluxes by NMR and GC-MS analyses of 13C-labeled metabolic product isotopomers. Metab Eng. 2007 Mar;9(2):177-92. Epub 2006 Nov 17. - Pubmed
DTHybrid score	0.9932
D-3-phosphoglycerate dehydrogenase
Name	D-3-phosphoglycerate dehydrogenase
Gene Name	PHGDH
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed Grant GA: A new family of 2-hydroxyacid dehydrogenases. Biochem Biophys Res Commun. 1989 Dec 29;165(3):1371-4. - Pubmed Goldsmith LA, O'Barr T: Serine biosynthesis in human hair follicles by the phosphorylated pathway: follicular 3-phosphoglycerate dehydrogenase. J Invest Dermatol. 1976 Jun;66(6):360-6. - Pubmed Grant GA, Hu Z, Xu XL: Cofactor binding to Escherichia coli D-3-phosphoglycerate dehydrogenase induces multiple conformations which alter effector binding. J Biol Chem. 2002 Oct 18;277(42):39548-53. Epub 2002 Aug 14. - Pubmed
DTHybrid score	1.1017
3-keto-steroid reductase
Name	3-keto-steroid reductase
Gene Name	HSD17B7
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score	1.1021
Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial
Name	Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial
Gene Name	IDH3G
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed Stein AM, Stein JH, Kirkman SK: Diphosphopyridine nucleotide specific isocitric dehydrogenase of mammalian mitochondria. I. On the roles of pyridine nucleotide transhydrogenase and the isocitric dehydrogenases in the respiration of mitochondria of normal and neoplastic tissues. Biochemistry. 1967 May;6(5):1370-9. - Pubmed SANWAL BD, ZINK MW, STACHOW CS: NICOTINAMIDE ADENINE DINUCLEOTIDE-SPECIFIC ISOCITRIC DEHYDROGENASE. A POSSIBLE REGULATORY PROTEIN. J Biol Chem. 1964 May;239:1597-603. - Pubmed Rose ZB: The stereochemistry of the nicotinamide adenine dinucleotide-specific isocitric dehydrogenase reaction. J Biol Chem. 1966 May 25;241(10):2311-3. - Pubmed
DTHybrid score	1.1022
Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial
Name	Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial
Gene Name	IDH3B
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed Stein AM, Stein JH, Kirkman SK: Diphosphopyridine nucleotide specific isocitric dehydrogenase of mammalian mitochondria. I. On the roles of pyridine nucleotide transhydrogenase and the isocitric dehydrogenases in the respiration of mitochondria of normal and neoplastic tissues. Biochemistry. 1967 May;6(5):1370-9. - Pubmed SANWAL BD, ZINK MW, STACHOW CS: NICOTINAMIDE ADENINE DINUCLEOTIDE-SPECIFIC ISOCITRIC DEHYDROGENASE. A POSSIBLE REGULATORY PROTEIN. J Biol Chem. 1964 May;239:1597-603. - Pubmed Rose ZB: The stereochemistry of the nicotinamide adenine dinucleotide-specific isocitric dehydrogenase reaction. J Biol Chem. 1966 May 25;241(10):2311-3. - Pubmed
DTHybrid score	1.1022
Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial
Name	Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial
Gene Name	IDH3A
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed PLAUT GW, SUNG SC: Diphosphopyridine nucleotide isocitric dehydrogenase from animal tissues. J Biol Chem. 1954 Mar;207(1):305-14. - Pubmed Stein AM, Stein JH, Kirkman SK: Diphosphopyridine nucleotide specific isocitric dehydrogenase of mammalian mitochondria. I. On the roles of pyridine nucleotide transhydrogenase and the isocitric dehydrogenases in the respiration of mitochondria of normal and neoplastic tissues. Biochemistry. 1967 May;6(5):1370-9. - Pubmed Rose ZB: The stereochemistry of the nicotinamide adenine dinucleotide-specific isocitric dehydrogenase reaction. J Biol Chem. 1966 May 25;241(10):2311-3. - Pubmed
DTHybrid score	1.1021
Estradiol 17-beta-dehydrogenase 1
Name	Estradiol 17-beta-dehydrogenase 1
Gene Name	HSD17B1
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed Pineda JA, Murdock GL, Watson RJ, Warren JC: Stereospecificity of hydrogen transfer by bovine testicular 20 alpha-hydroxysteroid dehydrogenase. J Steroid Biochem. 1989 Dec;33(6):1223-8. - Pubmed Fukuda T, Hirato K, Yanaihara T, Nakayama T: Microsomal 20 alpha-hydroxysteroid dehydrogenase activity for progesterone in human placenta. Endocrinol Jpn. 1986 Jun;33(3):361-8. - Pubmed Rimsay RL, Murphy GW, Martin CJ, Orr JC: The 20 alpha-hydroxysteroid dehydrogenase of Streptomyces hydrogenans. Eur J Biochem. 1988 Jun 1;174(2):437-42. - Pubmed
DTHybrid score	1.439
Estradiol 17-beta-dehydrogenase 2
Name	Estradiol 17-beta-dehydrogenase 2
Gene Name	HSD17B2
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed Fukuda T, Hirato K, Yanaihara T, Nakayama T: Microsomal 20 alpha-hydroxysteroid dehydrogenase activity for progesterone in human placenta. Endocrinol Jpn. 1986 Jun;33(3):361-8. - Pubmed Pineda JA, Murdock GL, Watson RJ, Warren JC: Stereospecificity of hydrogen transfer by bovine testicular 20 alpha-hydroxysteroid dehydrogenase. J Steroid Biochem. 1989 Dec;33(6):1223-8. - Pubmed Wintergalen N, Thole HH, Galla HJ, Schlegel W: Prostaglandin-E2 9-reductase from corpus luteum of pseudopregnant rabbit is a member of the aldo-keto reductase superfamily featuring 20 alpha-hydroxysteroid dehydrogenase activity. Eur J Biochem. 1995 Nov 15;234(1):264-70. - Pubmed
DTHybrid score	1.1021
11-cis retinol dehydrogenase
Name	11-cis retinol dehydrogenase
Gene Name	RDH5
Pharmacological action	unknown
Actions	Not Available
References	Dalfo D, Marques N, Albalat R: Analysis of the NADH-dependent retinaldehyde reductase activity of amphioxus retinol dehydrogenase enzymes enhances our understanding of the evolution of the retinol dehydrogenase family. FEBS J. 2007 Jul;274(14):3739-52. Epub 2007 Jul 2. - Pubmed
DTHybrid score	0.8923
GDH/6PGL endoplasmic bifunctional protein [Includes: Glucose 1-dehydrogenase
Name	GDH/6PGL endoplasmic bifunctional protein [Includes: Glucose 1-dehydrogenase
Gene Name	H6PD
Pharmacological action	unknown
Actions	Not Available
References	Siu E, Won K, Park CB: Electrochemical Regeneration of NADH Using Conductive Vanadia-Silica Xerogels. Biotechnol Prog. 2007 Feb 2;23(1):293-296. - Pubmed Lu Y, Mei L: Co-expression of P450 BM3 and glucose dehydrogenase by recombinant Escherichia coli and its application in an NADPH-dependent indigo production system. J Ind Microbiol Biotechnol. 2007 Mar;34(3):247-53. Epub 2006 Dec 14. - Pubmed Takenaka M, Verbitskiy D, van der Merwe JA, Zehrmann A, Plessmann U, Urlaub H, Brennicke A: In vitro RNA editing in plant mitochondria does not require added energy. FEBS Lett. 2007 Jun 12;581(14):2743-7. Epub 2007 May 21. - Pubmed Markova EV, Zotova NV, Savchenko AA, Titova NM, Slepov EV, Cherdantsev DV, Konovalenko AN: [Lymphocyte metabolism in patients with acute pancreatitis with different genotypes of GSTM1 and GSTT1 genes] Biomed Khim. 2006 May-Jun;52(3):317-26. - Pubmed Zhang M, Mullens C, Gorski W: Coimmobilization of dehydrogenases and their cofactors in electrochemical biosensors. Anal Chem. 2007 Mar 15;79(6):2446-50. Epub 2007 Feb 14. - Pubmed
DTHybrid score	1.1014
Estradiol 17-beta-dehydrogenase 8
Name	Estradiol 17-beta-dehydrogenase 8
Gene Name	HSD17B8
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score	0.9937
Aldo-keto reductase family 1 member C4
Name	Aldo-keto reductase family 1 member C4
Gene Name	AKR1C4
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed Atalla A, Breyer-Pfaff U, Maser E: Purification and characterization of oxidoreductases-catalyzing carbonyl reduction of the tobacco-specific nitrosamine 4-methylnitrosamino-1-(3-pyridyl)-1-butanone (NNK) in human liver cytosol. Xenobiotica. 2000 Aug;30(8):755-69. - Pubmed
DTHybrid score	1.1029
Inosine-5'-monophosphate dehydrogenase 2
Name	Inosine-5'-monophosphate dehydrogenase 2
Gene Name	IMPDH2
Pharmacological action	unknown
Actions	Not Available
References	Wang J, Zeevi A, Webber S, Girnita DM, Addonizio L, Selby R, Hutchinson IV, Burckart GJ: A novel variant L263F in human inosine 5'-monophosphate dehydrogenase 2 is associated with diminished enzyme activity. Pharmacogenet Genomics. 2007 Apr;17(4):283-90. - Pubmed
DTHybrid score	Not Available
Aldo-keto reductase family 1 member C3
Name	Aldo-keto reductase family 1 member C3
Gene Name	AKR1C3
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed Pineda JA, Murdock GL, Watson RJ, Warren JC: Stereospecificity of hydrogen transfer by bovine testicular 20 alpha-hydroxysteroid dehydrogenase. J Steroid Biochem. 1989 Dec;33(6):1223-8. - Pubmed Pineda JA, Murdock GL, Watson RJ, Warren JC: Stereospecificity of hydrogen transfer between progesterone and cofactor by human placental estradiol-17 beta dehydrogenase. J Steroid Biochem Mol Biol. 1990 Sep;37(1):65-70. - Pubmed Nicolas JC, Boussioux AM, Boularan AM, Descomps B, Crastes de Paulet A: Bioluminescent assay of femtomole levels of estrone and estradiol. Anal Biochem. 1983 Nov;135(1):141-5. - Pubmed
DTHybrid score	1.2723
15-hydroxyprostaglandin dehydrogenase [NAD+]
Name	15-hydroxyprostaglandin dehydrogenase [NAD+]
Gene Name	HPGD
Pharmacological action	unknown
Actions	Not Available
References	Gao L, He P, Sha J, Liu C, Dai L, Hui N, Ni X: Corticotropin-releasing hormone receptor type 1 and type 2 mediate differential effects on 15-hydroxy prostaglandin dehydrogenase expression in cultured human chorion trophoblasts. Endocrinology. 2007 Aug;148(8):3645-54. Epub 2007 Apr 26. - Pubmed
DTHybrid score	1.1025
GDP-L-fucose synthetase
Name	GDP-L-fucose synthetase
Gene Name	TSTA3
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score	1.1021
Aldo-keto reductase family 1 member C1
Name	Aldo-keto reductase family 1 member C1
Gene Name	AKR1C1
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed Pineda JA, Murdock GL, Watson RJ, Warren JC: Stereospecificity of hydrogen transfer by bovine testicular 20 alpha-hydroxysteroid dehydrogenase. J Steroid Biochem. 1989 Dec;33(6):1223-8. - Pubmed Fukuda T, Hirato K, Yanaihara T, Nakayama T: Microsomal 20 alpha-hydroxysteroid dehydrogenase activity for progesterone in human placenta. Endocrinol Jpn. 1986 Jun;33(3):361-8. - Pubmed Burczynski ME, Sridhar GR, Palackal NT, Penning TM: The reactive oxygen species--and Michael acceptor-inducible human aldo-keto reductase AKR1C1 reduces the alpha,beta-unsaturated aldehyde 4-hydroxy-2-nonenal to 1,4-dihydroxy-2-nonene. J Biol Chem. 2001 Jan 26;276(4):2890-7. Epub 2000 Nov 1. - Pubmed
DTHybrid score	1.2768
Corticosteroid 11-beta-dehydrogenase isozyme 1
Name	Corticosteroid 11-beta-dehydrogenase isozyme 1
Gene Name	HSD11B1
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed Diederich S, Hanke B, Oelkers W, Bahr V: Metabolism of dexamethasone in the human kidney: nicotinamide adenine dinucleotide-dependent 11beta-reduction. J Clin Endocrinol Metab. 1997 May;82(5):1598-602. - Pubmed Hermans JJ, Steckel B, Thijssen HH, Janssen BJ, Netter KJ, Maser E: Comparison of 11 beta-hydroxysteroid dehydrogenase in spontaneously hypertensive and Wistar-Kyoto rats. Steroids. 1995 Nov;60(11):773-9. - Pubmed
DTHybrid score	1.8507
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II
Name	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II
Gene Name	HSD3B2
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed Widenius TV, Orava MM, Vihko RK, Ylikahri RH, Eriksson CJ: Inhibition of testosterone biosynthesis by ethanol: multiple sites and mechanisms in dispersed Leydig cells. J Steroid Biochem. 1987 Aug;28(2):185-8. - Pubmed Fan DF, Troen P: Studies of the human testis. VII. Conversion of pregnenolone to progesterone. J Clin Endocrinol Metab. 1975 Sep;41(3):563-74. - Pubmed Thomas JL, Myers RP, Strickler RC: Analysis of coenzyme binding by human placental 3 beta-hydroxy-5-ene-steroid dehydrogenase and steroid 5----4-ene-isomerase using 5'-[p-(fluorosulfonyl)benzoyl]adenosine, an affinity labeling cofactor analog. J Steroid Biochem Mol Biol. 1991 Oct;39(4A):471-7. - Pubmed
DTHybrid score	1.1047
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I
Name	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I
Gene Name	HSD3B1
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed Widenius TV, Orava MM, Vihko RK, Ylikahri RH, Eriksson CJ: Inhibition of testosterone biosynthesis by ethanol: multiple sites and mechanisms in dispersed Leydig cells. J Steroid Biochem. 1987 Aug;28(2):185-8. - Pubmed Thomas JL, Myers RP, Rosik LO, Strickler RC: Affinity alkylation of human placental 3 beta-hydroxy-5-ene-steroid dehydrogenase and steroid 5----4-ene-isomerase by 2 alpha-bromoacetoxyprogesterone: evidence for separate dehydrogenase and isomerase sites on one protein. J Steroid Biochem. 1990 Jun;36(1-2):117-23. - Pubmed Ishii-Ohba H, Inano H, Tamaoki B: Testicular and adrenal 3 beta-hydroxy-5-ene-steroid dehydrogenase and 5-ene-4-ene isomerase. J Steroid Biochem. 1987;27(4-6):775-9. - Pubmed
DTHybrid score	1.1418
Inosine-5'-monophosphate dehydrogenase 1
Name	Inosine-5'-monophosphate dehydrogenase 1
Gene Name	IMPDH1
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed Bowne SJ, Sullivan LS, Mortimer SE, Hedstrom L, Zhu J, Spellicy CJ, Gire AI, Hughbanks-Wheaton D, Birch DG, Lewis RA, Heckenlively JR, Daiger SP: Spectrum and frequency of mutations in IMPDH1 associated with autosomal dominant retinitis pigmentosa and leber congenital amaurosis. Invest Ophthalmol Vis Sci. 2006 Jan;47(1):34-42. - Pubmed
DTHybrid score	Not Available
Trifunctional enzyme subunit alpha, mitochondrial
Name	Trifunctional enzyme subunit alpha, mitochondrial
Gene Name	HADHA
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score	1.1014
Aldehyde dehydrogenase, mitochondrial
Name	Aldehyde dehydrogenase, mitochondrial
Gene Name	ALDH2
Pharmacological action	unknown
Actions	Not Available
References	Quintanilla ME, Tampier L, Sapag A, Gerdtzen Z, Israel Y: Sex differences, alcohol dehydrogenase, acetaldehyde burst, and aversion to ethanol in the rat: a systems perspective. Am J Physiol Endocrinol Metab. 2007 Aug;293(2):E531-7. Epub 2007 May 8. - Pubmed Quintanilla ME, Israel Y, Sapag A, Tampier L: The UChA and UChB rat lines: metabolic and genetic differences influencing ethanol intake. Addict Biol. 2006 Sep;11(3-4):310-23. - Pubmed
DTHybrid score	1.0439
Corticosteroid 11-beta-dehydrogenase isozyme 2
Name	Corticosteroid 11-beta-dehydrogenase isozyme 2
Gene Name	HSD11B2
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed Mercer WR, Krozowski ZS: Localization of an 11 beta hydroxysteroid dehydrogenase activity to the distal nephron. Evidence for the existence of two species of dehydrogenase in the rat kidney. Endocrinology. 1992 Jan;130(1):540-3. - Pubmed Hermans JJ, Steckel B, Thijssen HH, Janssen BJ, Netter KJ, Maser E: Comparison of 11 beta-hydroxysteroid dehydrogenase in spontaneously hypertensive and Wistar-Kyoto rats. Steroids. 1995 Nov;60(11):773-9. - Pubmed
DTHybrid score	1.102
Aldo-keto reductase family 1 member C2
Name	Aldo-keto reductase family 1 member C2
Gene Name	AKR1C2
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed Rizner TL, Lin HK, Peehl DM, Steckelbroeck S, Bauman DR, Penning TM: Human type 3 3alpha-hydroxysteroid dehydrogenase (aldo-keto reductase 1C2) and androgen metabolism in prostate cells. Endocrinology. 2003 Jul;144(7):2922-32. - Pubmed Trauger JW, Jiang A, Stearns BA, LoGrasso PV: Kinetics of allopregnanolone formation catalyzed by human 3 alpha-hydroxysteroid dehydrogenase type III (AKR1C2). Biochemistry. 2002 Nov 12;41(45):13451-9. - Pubmed
DTHybrid score	1.1362
Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating
Name	Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating
Gene Name	NSDHL
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed Cunningham D, Swartzlander D, Liyanarachchi S, Davuluri RV, Herman GE: Changes in gene expression associated with loss of function of the NSDHL sterol dehydrogenase in mouse embryonic fibroblasts. J Lipid Res. 2005 Jun;46(6):1150-62. Epub 2005 Apr 1. - Pubmed
DTHybrid score	1.102
Aldehyde dehydrogenase 3B2
Name	Aldehyde dehydrogenase 3B2
Gene Name	ALDH3B2
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score	1.1033
Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial
Name	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial
Gene Name	ALDH6A1
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed Kedishvili NY, Popov KM, Harris RA: The effect of ligand binding on the proteolytic pattern of methylmalonate semialdehyde dehydrogenase. Arch Biochem Biophys. 1991 Oct;290(1):21-6. - Pubmed
DTHybrid score	1.1018
Aldehyde dehydrogenase, dimeric NADP-preferring
Name	Aldehyde dehydrogenase, dimeric NADP-preferring
Gene Name	ALDH3A1
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed Wroczynski P, Nowak M, Wierzchowski J, Szubert A, Polanski J: Activities of cytosolic aldehyde dehydrogenase isozymes in colon cancer: determination using selective, fluorimetric assays. Acta Pol Pharm. 2005 Nov-Dec;62(6):427-33. - Pubmed
DTHybrid score	1.0887
Retinal dehydrogenase 1
Name	Retinal dehydrogenase 1
Gene Name	ALDH1A1
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed Wroczynski P, Nowak M, Wierzchowski J, Szubert A, Polanski J: Activities of cytosolic aldehyde dehydrogenase isozymes in colon cancer: determination using selective, fluorimetric assays. Acta Pol Pharm. 2005 Nov-Dec;62(6):427-33. - Pubmed Russo J, Barnes A, Berger K, Desgrosellier J, Henderson J, Kanters A, Merkov L: 4-(N,N-dipropylamino)benzaldehyde inhibits the oxidation of all-trans retinal to all-trans retinoic acid by ALDH1A1, but not the differentiation of HL-60 promyelocytic leukemia cells exposed to all-trans retinal. BMC Pharmacol. 2002;2:4. Epub 2002 Feb 12. - Pubmed
DTHybrid score	0.8654
Glyceraldehyde-3-phosphate dehydrogenase, testis-specific
Name	Glyceraldehyde-3-phosphate dehydrogenase, testis-specific
Gene Name	GAPDHS
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed Maeda K, Nagata H, Nonaka A, Kataoka K, Tanaka M, Shizukuishi S: Oral streptococcal glyceraldehyde-3-phosphate dehydrogenase mediates interaction with Porphyromonas gingivalis fimbriae. Microbes Infect. 2004 Nov;6(13):1163-70. - Pubmed Graciet E, Lebreton S, Camadro JM, Gontero B: Characterization of native and recombinant A4 glyceraldehyde 3-phosphate dehydrogenase. Kinetic evidence for confromation changes upon association with the small protein CP12. Eur J Biochem. 2003 Jan;270(1):129-36. - Pubmed Ismail SA, Park HW: Structural analysis of human liver glyceraldehyde-3-phosphate dehydrogenase. Acta Crystallogr D Biol Crystallogr. 2005 Nov;61(Pt 11):1508-13. Epub 2005 Oct 19. - Pubmed
DTHybrid score	1.6932
4-trimethylaminobutyraldehyde dehydrogenase
Name	4-trimethylaminobutyraldehyde dehydrogenase
Gene Name	ALDH9A1
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed Prieto MI, Martin J, Balana-Fouce R, Garrido-Pertierra A: Properties of gamma-aminobutyraldehyde dehydrogenase from Escherichia coli. Biochimie. 1987 Nov-Dec;69(11-12):1161-8. - Pubmed Testore G, Colombatto S, Silvagno F, Bedino S: Purification and kinetic characterization of gamma-aminobutyraldehyde dehydrogenase from rat liver. Int J Biochem Cell Biol. 1995 Nov;27(11):1201-10. - Pubmed
DTHybrid score	1.0881
Aldehyde dehydrogenase 1A3
Name	Aldehyde dehydrogenase 1A3
Gene Name	ALDH1A3
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed Graham CE, Brocklehurst K, Pickersgill RW, Warren MJ: Characterization of retinaldehyde dehydrogenase 3. Biochem J. 2006 Feb 15;394(Pt 1):67-75. - Pubmed
DTHybrid score	0.8946
Aldehyde dehydrogenase X, mitochondrial
Name	Aldehyde dehydrogenase X, mitochondrial
Gene Name	ALDH1B1
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score	1.1023
Aldehyde dehydrogenase 3B1
Name	Aldehyde dehydrogenase 3B1
Gene Name	ALDH3B1
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score	1.1032
Glyceraldehyde-3-phosphate dehydrogenase
Name	Glyceraldehyde-3-phosphate dehydrogenase
Gene Name	GAPDH
Pharmacological action	unknown
Actions	Not Available
References	Markova EV, Zotova NV, Savchenko AA, Titova NM, Slepov EV, Cherdantsev DV, Konovalenko AN: [Lymphocyte metabolism in patients with acute pancreatitis with different genotypes of GSTM1 and GSTT1 genes] Biomed Khim. 2006 May-Jun;52(3):317-26. - Pubmed Ido Y: Pyridine nucleotide redox abnormalities in diabetes. Antioxid Redox Signal. 2007 Jul;9(7):931-42. - Pubmed Trost P, Fermani S, Marri L, Zaffagnini M, Falini G, Scagliarini S, Pupillo P, Sparla F: Thioredoxin-dependent regulation of photosynthetic glyceraldehyde-3-phosphate dehydrogenase: autonomous vs. CP12-dependent mechanisms. Photosynth Res. 2006 Sep;89(2-3):263-75. Epub 2006 Sep 22. - Pubmed Swearengin TA, Fibuch EE, Seidler NW: Sevoflurane modulates the activity of glyceraldehyde 3-phosphate dehydrogenase. J Enzyme Inhib Med Chem. 2006 Oct;21(5):575-9. - Pubmed
DTHybrid score	1.4229
Retinal dehydrogenase 2
Name	Retinal dehydrogenase 2
Gene Name	ALDH1A2
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed Lamb AL, Newcomer ME: The structure of retinal dehydrogenase type II at 2.7 A resolution: implications for retinal specificity. Biochemistry. 1999 May 11;38(19):6003-11. - Pubmed Russo J, Barnes A, Berger K, Desgrosellier J, Henderson J, Kanters A, Merkov L: 4-(N,N-dipropylamino)benzaldehyde inhibits the oxidation of all-trans retinal to all-trans retinoic acid by ALDH1A1, but not the differentiation of HL-60 promyelocytic leukemia cells exposed to all-trans retinal. BMC Pharmacol. 2002;2:4. Epub 2002 Feb 12. - Pubmed
DTHybrid score	0.9198
Fatty aldehyde dehydrogenase
Name	Fatty aldehyde dehydrogenase
Gene Name	ALDH3A2
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed Bognar A, Meighen E: Mechanism of a long-chain fatty aldehyde dehydrogenase induced during the development of bioluminescence in Beneckea harveyi. Can J Biochem Cell Biol. 1983 May;61(5):301-6. - Pubmed
DTHybrid score	1.1024
Succinate semialdehyde dehydrogenase, mitochondrial
Name	Succinate semialdehyde dehydrogenase, mitochondrial
Gene Name	ALDH5A1
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score	0.8488
Alpha-aminoadipic semialdehyde dehydrogenase
Name	Alpha-aminoadipic semialdehyde dehydrogenase
Gene Name	ALDH7A1
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed de La Fuente JL, Rumbero A, Martin JF, Liras P: Delta-1-piperideine-6-carboxylate dehydrogenase, a new enzyme that forms alpha-aminoadipate in Streptomyces clavuligerus and other cephamycin C-producing actinomycetes. Biochem J. 1997 Oct 1;327 ( Pt 1):59-64. - Pubmed
DTHybrid score	1.1017
Flavin reductase
Name	Flavin reductase
Gene Name	BLVRB
Pharmacological action	unknown
Actions	Not Available
References	Deng D, Li X, Fang X, Sun G: Characterization of two components of the 2-naphthoate monooxygenase system from Burkholderia sp. strain JT1500. FEMS Microbiol Lett. 2007 Aug;273(1):22-7. Epub 2007 Jun 7. - Pubmed
DTHybrid score	1.2866
Pyrroline-5-carboxylate reductase 2
Name	Pyrroline-5-carboxylate reductase 2
Gene Name	PYCR2
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed Murahama M, Yoshida T, Hayashi F, Ichino T, Sanada Y, Wada K: Purification and characterization of Delta(1)-pyrroline-5-carboxylate reductase isoenzymes, indicating differential distribution in spinach (Spinacia oleracea L.) leaves. Plant Cell Physiol. 2001 Jul;42(7):742-50. - Pubmed
DTHybrid score	0.8602
Pyrroline-5-carboxylate reductase 1
Name	Pyrroline-5-carboxylate reductase 1
Gene Name	PYCR1
Pharmacological action	unknown
Actions	Not Available
References	Wang ZQ, Yuan YZ, Ou JQ, Lin QH, Zhang CF: Glutamine synthetase and glutamate dehydrogenase contribute differentially to proline accumulation in leaves of wheat (Triticum aestivum) seedlings exposed to different salinity. J Plant Physiol. 2007 Jun;164(6):695-701. Epub 2006 Jun 14. - Pubmed Forlani G, Giberti S, Berlicki L, Petrollino D, Kafarski P: Plant P5C reductase as a new target for aminomethylenebisphosphonates. J Agric Food Chem. 2007 May 30;55(11):4340-7. Epub 2007 May 3. - Pubmed
DTHybrid score	0.8602
Glutamate dehydrogenase 1, mitochondrial
Name	Glutamate dehydrogenase 1, mitochondrial
Gene Name	GLUD1
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score	0.8888
Pyruvate dehydrogenase E1 component subunit beta, mitochondrial
Name	Pyruvate dehydrogenase E1 component subunit beta, mitochondrial
Gene Name	PDHB
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed Taylor SI, Mukherjee C, Jungas RL: Regulation of pyruvate dehydrogenase in isolated rat liver mitochondria. Effects of octanoate, oxidation-reduction state, and adenosine triphosphate to adenosine diphosphate ratio. J Biol Chem. 1975 Mar 25;250(6):2028-35. - Pubmed
DTHybrid score	0.84
Pyruvate dehydrogenase E1 component alpha subunit, testis-specific form, mitochondrial
Name	Pyruvate dehydrogenase E1 component alpha subunit, testis-specific form, mitochondrial
Gene Name	PDHA2
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score	1.1033
Pyruvate dehydrogenase E1 component alpha subunit, somatic form, mitochondrial
Name	Pyruvate dehydrogenase E1 component alpha subunit, somatic form, mitochondrial
Gene Name	PDHA1
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score	1.1033
Biliverdin reductase A
Name	Biliverdin reductase A
Gene Name	BLVRA
Pharmacological action	unknown
Actions	Not Available
References	Franklin E, Browne S, Hayes J, Boland C, Dunne A, Elliot G, Mantle TJ: Activation of biliverdin-IXalpha reductase by inorganic phosphate and related anions. Biochem J. 2007 Jul 1;405(1):61-7. - Pubmed
DTHybrid score	1.0885
Short-chain specific acyl-CoA dehydrogenase, mitochondrial
Name	Short-chain specific acyl-CoA dehydrogenase, mitochondrial
Gene Name	ACADS
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score	0.9609
Dihydrofolate reductase
Name	Dihydrofolate reductase
Gene Name	DHFR
Pharmacological action	unknown
Actions	Not Available
References	Argyrou A, Jin L, Siconilfi-Baez L, Angeletti RH, Blanchard JS: Proteome-wide profiling of isoniazid targets in Mycobacterium tuberculosis. Biochemistry. 2006 Nov 28;45(47):13947-53. - Pubmed Vickers TJ, Orsomando G, de la Garza RD, Scott DA, Kang SO, Hanson AD, Beverley SM: Biochemical and genetic analysis of methylenetetrahydrofolate reductase in Leishmania metabolism and virulence. J Biol Chem. 2006 Dec 15;281(50):38150-8. Epub 2006 Oct 10. - Pubmed
DTHybrid score	1.5023
2-oxoglutarate dehydrogenase E1 component, mitochondrial
Name	2-oxoglutarate dehydrogenase E1 component, mitochondrial
Gene Name	OGDH
Pharmacological action	unknown
Actions	Not Available
References	Mailloux RJ, Beriault R, Lemire J, Singh R, Chenier DR, Hamel RD, Appanna VD: The tricarboxylic acid cycle, an ancient metabolic network with a novel twist. PLoS ONE. 2007 Aug 1;2(1):e690. - Pubmed
DTHybrid score	0.8304
Glutamate dehydrogenase 2, mitochondrial
Name	Glutamate dehydrogenase 2, mitochondrial
Gene Name	GLUD2
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score	0.9019
7-dehydrocholesterol reductase
Name	7-dehydrocholesterol reductase
Gene Name	DHCR7
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score	1.1017
Ribosyldihydronicotinamide dehydrogenase [quinone]
Name	Ribosyldihydronicotinamide dehydrogenase [quinone]
Gene Name	NQO2
Pharmacological action	unknown
Actions	Not Available
References	Jamieson D, Tung AT, Knox RJ, Boddy AV: Reduction of mitomycin C is catalysed by human recombinant NRH:quinone oxidoreductase 2 using reduced nicotinamide adenine dinucleotide as an electron donating co-factor. Br J Cancer. 2006 Nov 6;95(9):1229-33. Epub 2006 Oct 10. - Pubmed Iskander K, Li J, Han S, Zheng B, Jaiswal AK: NQO1 and NQO2 regulation of humoral immunity and autoimmunity. J Biol Chem. 2006 Oct 13;281(41):30917-24. Epub 2006 Aug 10. - Pubmed
DTHybrid score	1.1842
NADH-ubiquinone oxidoreductase chain 2
Name	NADH-ubiquinone oxidoreductase chain 2
Gene Name	MT-ND2
Pharmacological action	unknown
Actions	binder
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed Nikonova EV, Vijayasarathy C, Zhang L, Cater JR, Galante RJ, Ward SE, Avadhani NG, Pack AI: Differences in activity of cytochrome C oxidase in brain between sleep and wakefulness. Sleep. 2005 Jan 1;28(1):21-7. - Pubmed Zhang HB, Chen SL, Liu JZ, Xiao B, Chen ZB, Wang HJ: [The changes of gene expression in multiple myeloma treated with thalidomide] Zhonghua Nei Ke Za Zhi. 2003 May;42(5):300-2. - Pubmed Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score	1.102
Alpha-aminoadipic semialdehyde synthase, mitochondrial
Name	Alpha-aminoadipic semialdehyde synthase, mitochondrial
Gene Name	AASS
Pharmacological action	unknown
Actions	Not Available
References	Xu H, West AH, Cook PF: Determinants of substrate specificity for saccharopine dehydrogenase from Saccharomyces cerevisiae. Biochemistry. 2007 Jun 26;46(25):7625-36. Epub 2007 Jun 2. - Pubmed Xu H, West AH, Cook PF: Overall kinetic mechanism of saccharopine dehydrogenase from Saccharomyces cerevisiae. Biochemistry. 2006 Oct 3;45(39):12156-66. - Pubmed Xu H, Alguindigue SS, West AH, Cook PF: A proposed proton shuttle mechanism for saccharopine dehydrogenase from Saccharomyces cerevisiae. Biochemistry. 2007 Jan 23;46(3):871-82. - Pubmed
DTHybrid score	1.1874
NADH-ubiquinone oxidoreductase chain 3
Name	NADH-ubiquinone oxidoreductase chain 3
Gene Name	MT-ND3
Pharmacological action	unknown
Actions	binder
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score	1.1033
NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial
Name	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial
Gene Name	NDUFS7
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed Schuler F, Yano T, Di Bernardo S, Yagi T, Yankovskaya V, Singer TP, Casida JE: NADH-quinone oxidoreductase: PSST subunit couples electron transfer from iron-sulfur cluster N2 to quinone. Proc Natl Acad Sci U S A. 1999 Mar 30;96(7):4149-53. - Pubmed Hyslop SJ, Duncan AM, Pitkanen S, Robinson BH: Assignment of the PSST subunit gene of human mitochondrial complex I to chromosome 19p13. Genomics. 1996 Nov 1;37(3):375-80. - Pubmed Albracht SP: Intimate relationships of the large and the small subunits of all nickel hydrogenases with two nuclear-encoded subunits of mitochondrial NADH: ubiquinone oxidoreductase. Biochim Biophys Acta. 1993 Sep 13;1144(2):221-4. - Pubmed
DTHybrid score	0.9018
C-1-tetrahydrofolate synthase, cytoplasmic
Name	C-1-tetrahydrofolate synthase, cytoplasmic
Gene Name	MTHFD1
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score	1.4492
Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial
Name	Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial
Gene Name	MTHFD2
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score	0.8884
Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial
Name	Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial
Gene Name	ALDH4A1
Pharmacological action	unknown
Actions	Not Available
References	Inagaki E, Ohshima N, Takahashi H, Kuroishi C, Yokoyama S, Tahirov TH: Crystal structure of Thermus thermophilus Delta1-pyrroline-5-carboxylate dehydrogenase. J Mol Biol. 2006 Sep 22;362(3):490-501. Epub 2006 Jul 29. - Pubmed
DTHybrid score	1.1017
NADH-cytochrome b5 reductase 3
Name	NADH-cytochrome b5 reductase 3
Gene Name	CYB5R3
Pharmacological action	unknown
Actions	Not Available
References	Roma GW, Crowley LJ, Barber MJ: Expression and characterization of a functional canine variant of cytochrome b5 reductase. Arch Biochem Biophys. 2006 Aug 1;452(1):69-82. Epub 2006 May 24. - Pubmed Nussenzveig RH, Lingam HB, Gaikwad A, Zhu Q, Jing N, Prchal JT: A novel mutation of the cytochrome-b5 reductase gene in an Indian patient: the molecular basis of type I methemoglobinemia. Haematologica. 2006 Nov;91(11):1542-5. - Pubmed Kim S, Suga M, Ogasahara K, Ikegami T, Minami Y, Yubisui T, Tsukihara T: Structure of Physarum polycephalum cytochrome b5 reductase at 1.56 A resolution. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 Apr 1;63(Pt 4):274-9. Epub 2007 Mar 23. - Pubmed Kurian JR, Chin NA, Longlais BJ, Hayes KL, Trepanier LA: Reductive detoxification of arylhydroxylamine carcinogens by human NADH cytochrome b5 reductase and cytochrome b5. Chem Res Toxicol. 2006 Oct;19(10):1366-73. - Pubmed Ikegami T, Kameyama E, Yamamoto SY, Minami Y, Yubisui T: Structure and properties of the recombinant NADH-cytochrome b5 reductase of Physarum polycephalum. Biosci Biotechnol Biochem. 2007 Mar;71(3):783-90. Epub 2007 Mar 7. - Pubmed
DTHybrid score	0.9771
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11
Name	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11
Gene Name	NDUFA11
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score	1.1033
NADH-ubiquinone oxidoreductase chain 4
Name	NADH-ubiquinone oxidoreductase chain 4
Gene Name	MT-ND4
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed Shen XY, Zacal N, Singh G, Rainbow AJ: Alterations in mitochondrial and apoptosis-regulating gene expression in photodynamic therapy-resistant variants of HT29 colon carcinoma cells. Photochem Photobiol. 2005 Mar-Apr;81(2):306-13. - Pubmed Carper DA, Sun JK, Iwata T, Zigler JS Jr, Ibaraki N, Lin LR, Reddy V: Oxidative stress induces differential gene expression in a human lens epithelial cell line. Invest Ophthalmol Vis Sci. 1999 Feb;40(2):400-6. - Pubmed Dzelzkalns VA, Obinger C, Regelsberger G, Niederhauser H, Kamensek M, Peschek GA, Bogorad L: Deletion of the structural gene for the NADH-dehydrogenase subunit 4 of Synechocystis 6803 alters respiratory properties. Plant Physiol. 1994 Dec;106(4):1435-42. - Pubmed
DTHybrid score	1.1018
Dihydropteridine reductase
Name	Dihydropteridine reductase
Gene Name	QDPR
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed Nakanishi N, Ozawa K, Yamada S: Determination of NADPH-specific dihydropteridine reductase in extract from human, monkey, and bovine livers by single radial immunodiffusion: selective assay differentiating NADPH- and NADH-specific enzymes. J Biochem (Tokyo). 1986 May;99(5):1311-5. - Pubmed van der Heiden C, Brink W: Spectral studies of the interaction of the substrate 'quinonoid' 6-methyl dihydropterine and the coenzyme NADH used as marker in the dihydropteridine reductase assay. J Inherit Metab Dis. 1982;5(3):132-6. - Pubmed Lee PL, Halloran C, Cross AR, Beutler E: NADH-ferric reductase activity associated with dihydropteridine reductase. Biochem Biophys Res Commun. 2000 May 19;271(3):788-95. - Pubmed
DTHybrid score	0.9135
NADH-ubiquinone oxidoreductase chain 1
Name	NADH-ubiquinone oxidoreductase chain 1
Gene Name	MT-ND1
Pharmacological action	unknown
Actions	binder
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score	0.5992
NAD(P) transhydrogenase, mitochondrial
Name	NAD(P) transhydrogenase, mitochondrial
Gene Name	NNT
Pharmacological action	unknown
Actions	Not Available
References	Kabus A, Georgi T, Wendisch VF, Bott M: Expression of the Escherichia coli pntAB genes encoding a membrane-bound transhydrogenase in Corynebacterium glutamicum improves L-lysine formation. Appl Microbiol Biotechnol. 2007 May;75(1):47-53. Epub 2007 Jan 11. - Pubmed
DTHybrid score	1.5229
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5
Name	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5
Gene Name	NDUFA5
Pharmacological action	unknown
Actions	Not Available
References	Chen CL, Zhang L, Yeh A, Chen CA, Green-Church KB, Zweier JL, Chen YR: Site-specific S-glutathiolation of mitochondrial NADH ubiquinone reductase. Biochemistry. 2007 May 15;46(19):5754-65. Epub 2007 Apr 20. - Pubmed Belevich G, Euro L, Wikstrom M, Verkhovskaya M: Role of the conserved arginine 274 and histidine 224 and 228 residues in the NuoCD subunit of complex I from Escherichia coli. Biochemistry. 2007 Jan 16;46(2):526-33. - Pubmed
DTHybrid score	1.1034
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial
Name	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial
Gene Name	NDUFA9
Pharmacological action	unknown
Actions	Not Available
References	Barker CD, Reda T, Hirst J: The flavoprotein subcomplex of complex I (NADH:ubiquinone oxidoreductase) from bovine heart mitochondria: insights into the mechanisms of NADH oxidation and NAD+ reduction from protein film voltammetry. Biochemistry. 2007 Mar 20;46(11):3454-64. Epub 2007 Feb 27. - Pubmed Balaban RS: Maintenance of the metabolic homeostasis of the heart: developing a systems analysis approach. Ann N Y Acad Sci. 2006 Oct;1080:140-53. - Pubmed Matsuzaki S, Szweda LI: Inhibition of complex I by Ca2+ reduces electron transport activity and the rate of superoxide anion production in cardiac submitochondrial particles. Biochemistry. 2007 Feb 6;46(5):1350-7. - Pubmed Fisher N, Bray PG, Ward SA, Biagini GA: The malaria parasite type II NADH:quinone oxidoreductase: an alternative enzyme for an alternative lifestyle. Trends Parasitol. 2007 Jul;23(7):305-10. Epub 2007 May 10. - Pubmed Liu Y, Qiao DR, Zheng HB, Dai XL, Bai LH, Zeng J, Cao Y: Cloning and sequence analysis of the gene encoding 19-kD subunit of Complex I from Dunaliella salina. Mol Biol Rep. 2007 May 26;. - Pubmed
DTHybrid score	1.102
NADH-ubiquinone oxidoreductase chain 4L
Name	NADH-ubiquinone oxidoreductase chain 4L
Gene Name	MT-ND4L
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score	1.1037
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial
Name	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial
Gene Name	NDUFA10
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score	1.102
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7
Name	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7
Gene Name	NDUFA7
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score	1.1035
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1
Name	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1
Gene Name	NDUFA1
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed Au HC, Seo BB, Matsuno-Yagi A, Yagi T, Scheffler IE: The NDUFA1 gene product (MWFE protein) is essential for activity of complex I in mammalian mitochondria. Proc Natl Acad Sci U S A. 1999 Apr 13;96(8):4354-9. - Pubmed Raha S, Myint AT, Johnstone L, Robinson BH: Control of oxygen free radical formation from mitochondrial complex I: roles for protein kinase A and pyruvate dehydrogenase kinase. Free Radic Biol Med. 2002 Mar 1;32(5):421-30. - Pubmed
DTHybrid score	1.1043
NADH-ubiquinone oxidoreductase chain 6
Name	NADH-ubiquinone oxidoreductase chain 6
Gene Name	MT-ND6
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score	1.1029
NADH-ubiquinone oxidoreductase chain 5
Name	NADH-ubiquinone oxidoreductase chain 5
Gene Name	MT-ND5
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed Johnson WE, O'Brien SJ: Phylogenetic reconstruction of the Felidae using 16S rRNA and NADH-5 mitochondrial genes. J Mol Evol. 1997;44 Suppl 1:S98-116. - Pubmed Bao HG, Zhao CJ, Li JY, Wu Ch: Association of MT-ND5 gene variation with mitochondrial respiratory control ratio and NADH dehydrogenase activity in Tibet chicken embryos. Anim Genet. 2007 Oct;38(5):514-6. Epub 2007 Jul 5. - Pubmed
DTHybrid score	1.1015
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4
Name	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4
Gene Name	NDUFA4
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score	1.1044
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6
Name	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6
Gene Name	NDUFA6
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score	1.1032
Acyl carrier protein, mitochondrial
Name	Acyl carrier protein, mitochondrial
Gene Name	NDUFAB1
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score	1.103
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2
Name	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2
Gene Name	NDUFA2
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score	1.1037
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8
Name	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8
Gene Name	NDUFA8
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed Triepels R, van den Heuvel L, Loeffen J, Smeets R, Trijbels F, Smeitink J: The nuclear-encoded human NADH:ubiquinone oxidoreductase NDUFA8 subunit: cDNA cloning, chromosomal localization, tissue distribution, and mutation detection in complex-I-deficient patients. Hum Genet. 1998 Nov;103(5):557-63. - Pubmed
DTHybrid score	1.1029
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3
Name	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3
Gene Name	NDUFA3
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score	1.104
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial
Name	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial
Gene Name	NDUFB8
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score	1.1027
NADH dehydrogenase [ubiquinone] 1 subunit C2
Name	NADH dehydrogenase [ubiquinone] 1 subunit C2
Gene Name	NDUFC2
Pharmacological action	unknown
Actions	Not Available
References	Gyan S, Shiohira Y, Sato I, Takeuchi M, Sato T: Regulatory loop between redox sensing of the NADH/NAD(+) ratio by Rex (YdiH) and oxidation of NADH by NADH dehydrogenase Ndh in Bacillus subtilis. J Bacteriol. 2006 Oct;188(20):7062-71. - Pubmed Quiles MJ: Stimulation of chlororespiration by heat and high light intensity in oat plants. Plant Cell Environ. 2006 Aug;29(8):1463-70. - Pubmed Brooijmans RJ, Poolman B, Schuurman-Wolters GK, de Vos WM, Hugenholtz J: Generation of a membrane potential by Lactococcus lactis through aerobic electron transport. J Bacteriol. 2007 Jul;189(14):5203-9. Epub 2007 May 11. - Pubmed Bao HG, Zhao CJ, Li JY, Wu Ch: Association of MT-ND5 gene variation with mitochondrial respiratory control ratio and NADH dehydrogenase activity in Tibet chicken embryos. Anim Genet. 2007 Oct;38(5):514-6. Epub 2007 Jul 5. - Pubmed Zhu X, Liu B, Zhou S, Chen YR, Deng Y, Zweier JL, He G: Ischemic preconditioning prevents in vivo hyperoxygenation in postischemic myocardium with preservation of mitochondrial oxygen consumption. Am J Physiol Heart Circ Physiol. 2007 Sep;293(3):H1442-50. Epub 2007 May 18. - Pubmed
DTHybrid score	0.8451
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1
Name	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1
Gene Name	NDUFB1
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score	1.1044
NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
Name	NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
Gene Name	NDUFS1
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score	1.1014
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10
Name	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10
Gene Name	NDUFB10
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score	1.1027
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4
Name	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4
Gene Name	NDUFB4
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score	1.1033
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3
Name	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3
Gene Name	NDUFB3
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score	1.1037
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial
Name	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial
Gene Name	NDUFB2
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score	1.1036
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7
Name	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7
Gene Name	NDUFB7
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed Raha S, Myint AT, Johnstone L, Robinson BH: Control of oxygen free radical formation from mitochondrial complex I: roles for protein kinase A and pyruvate dehydrogenase kinase. Free Radic Biol Med. 2002 Mar 1;32(5):421-30. - Pubmed
DTHybrid score	1.1031
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9
Name	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9
Gene Name	NDUFB9
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score	1.1028
NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial
Name	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial
Gene Name	NDUFS2
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score	0.9009
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial
Name	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial
Gene Name	NDUFB5
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score	1.1028
NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial
Name	NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial
Gene Name	NDUFC1
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score	1.1042
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6
Name	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6
Gene Name	NDUFB6
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score	1.1033
NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial
Name	NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial
Gene Name	NDUFV3
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score	1.1036
Dihydrolipoyl dehydrogenase, mitochondrial
Name	Dihydrolipoyl dehydrogenase, mitochondrial
Gene Name	DLD
Pharmacological action	unknown
Actions	Not Available
References	Yan LJ, Yang SH, Shu H, Prokai L, Forster MJ: Histochemical staining and quantification of dihydrolipoamide dehydrogenase diaphorase activity using blue native PAGE. Electrophoresis. 2007 Apr;28(7):1036-45. - Pubmed Gutierrez-Correa J: Trypanosoma cruzi dihydrolipoamide dehydrogenase as target for phenothiazine cationic radicals. Effect of antioxidants. Curr Drug Targets. 2006 Sep;7(9):1155-79. - Pubmed Islam MM, Wallin R, Wynn RM, Conway M, Fujii H, Mobley JA, Chuang DT, Hutson SM: A novel branched-chain amino acid metabolon. Protein-protein interactions in a supramolecular complex. J Biol Chem. 2007 Apr 20;282(16):11893-903. Epub 2007 Feb 21. - Pubmed
DTHybrid score	0.9767
NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial
Name	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial
Gene Name	NDUFS3
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score	0.9015
Glutathione reductase, mitochondrial
Name	Glutathione reductase, mitochondrial
Gene Name	GSR
Pharmacological action	unknown
Actions	Not Available
References	Knapp KG, Swartz JR: Evidence for an additional disulfide reduction pathway in Escherichia coli. J Biosci Bioeng. 2007 Apr;103(4):373-6. - Pubmed Aon MA, Cortassa S, Maack C, O'Rourke B: Sequential opening of mitochondrial ion channels as a function of glutathione redox thiol status. J Biol Chem. 2007 Jul 27;282(30):21889-900. Epub 2007 May 31. - Pubmed Wan C, Li S, Wen L, Kong J, Wang K, Zhu Y: Damage of oxidative stress on mitochondria during microspores development in Honglian CMS line of rice. Plant Cell Rep. 2007 Mar;26(3):373-82. Epub 2006 Oct 12. - Pubmed Cheng Z, Arscott LD, Ballou DP, Williams CH Jr: The relationship of the redox potentials of thioredoxin and thioredoxin reductase from Drosophila melanogaster to the enzymatic mechanism: reduced thioredoxin is the reductant of glutathione in Drosophila. Biochemistry. 2007 Jul 3;46(26):7875-85. Epub 2007 Jun 6. - Pubmed Gazaryan IG, Krasinskaya IP, Kristal BS, Brown AM: Zinc irreversibly damages major enzymes of energy production and antioxidant defense prior to mitochondrial permeability transition. J Biol Chem. 2007 Aug 17;282(33):24373-80. Epub 2007 Jun 12. - Pubmed
DTHybrid score	1.4992
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12
Name	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12
Gene Name	NDUFA12
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score	1.1028
NADH dehydrogenase [ubiquinone] iron-sulfur protein 5
Name	NADH dehydrogenase [ubiquinone] iron-sulfur protein 5
Gene Name	NDUFS5
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed Loeffen J, Smeets R, Smeitink J, Triepels R, Sengers R, Trijbels F, van den Heuvel L: The human NADH: ubiquinone oxidoreductase NDUFS5 (15 kDa) subunit: cDNA cloning, chromosomal localization, tissue distribution and the absence of mutations in isolated complex I-deficient patients. J Inherit Metab Dis. 1999 Feb;22(1):19-28. - Pubmed
DTHybrid score	1.1034
NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial
Name	NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial
Gene Name	NDUFS4
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed Papa S, Sardanelli AM, Scacco S, Petruzzella V, Technikova-Dobrova Z, Vergari R, Signorile A: The NADH: ubiquinone oxidoreductase (complex I) of the mammalian respiratory chain and the cAMP cascade. J Bioenerg Biomembr. 2002 Feb;34(1):1-10. - Pubmed Petruzzella V, Vergari R, Puzziferri I, Boffoli D, Lamantea E, Zeviani M, Papa S: A nonsense mutation in the NDUFS4 gene encoding the 18 kDa (AQDQ) subunit of complex I abolishes assembly and activity of the complex in a patient with Leigh-like syndrome. Hum Mol Genet. 2001 Mar 1;10(5):529-35. - Pubmed Raha S, Myint AT, Johnstone L, Robinson BH: Control of oxygen free radical formation from mitochondrial complex I: roles for protein kinase A and pyruvate dehydrogenase kinase. Free Radic Biol Med. 2002 Mar 1;32(5):421-30. - Pubmed
DTHybrid score	1.1028
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial
Name	NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial
Gene Name	NDUFV1
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed Schuelke M, Loeffen J, Mariman E, Smeitink J, van den Heuvel L: Cloning of the human mitochondrial 51 kDa subunit (NDUFV1) reveals a 100% antisense homology of its 3'UTR with the 5'UTR of the gamma-interferon inducible protein (IP-30) precursor: is this a link between mitochondrial myopathy and inflammation? Biochem Biophys Res Commun. 1998 Apr 17;245(2):599-606. - Pubmed Ali ST, Duncan AM, Schappert K, Heng HH, Tsui LC, Chow W, Robinson BH: Chromosomal localization of the human gene encoding the 51-kDa subunit of mitochondrial complex I (NDUFV1) to 11q13. Genomics. 1993 Nov;18(2):435-9. - Pubmed Grad LI, Lemire BD: Mitochondrial complex I mutations in Caenorhabditis elegans produce cytochrome c oxidase deficiency, oxidative stress and vitamin-responsive lactic acidosis. Hum Mol Genet. 2004 Feb 1;13(3):303-14. Epub 2003 Dec 8. - Pubmed
DTHybrid score	1.1017
NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial
Name	NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial
Gene Name	NDUFV2
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed Paunesku T, Chang-Liu CM, Shearin-Jones P, Watson C, Milton J, Oryhon J, Salbego D, Milosavljevic A, Woloschak GE: Identification of genes regulated by UV/salicylic acid. Int J Radiat Biol. 2000 Feb;76(2):189-98. - Pubmed
DTHybrid score	1.1025
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13
Name	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13
Gene Name	NDUFA13
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score	1.1032
Cysteine dioxygenase type 1
Name	Cysteine dioxygenase type 1
Gene Name	CDO1
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score	0.8414
NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial
Name	NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial
Gene Name	NDUFS6
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score	1.1032
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2
Name	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2
Gene Name	NDUFA4L2
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score	1.1045
NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial
Name	NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial
Gene Name	NDUFS8
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed Albracht SP, Hedderich R: Learning from hydrogenases: location of a proton pump and of a second FMN in bovine NADH--ubiquinone oxidoreductase (Complex I). FEBS Lett. 2000 Nov 17;485(1):1-6. - Pubmed Loeffen J, Smeitink J, Triepels R, Smeets R, Schuelke M, Sengers R, Trijbels F, Hamel B, Mullaart R, van den Heuvel L: The first nuclear-encoded complex I mutation in a patient with Leigh syndrome. Am J Hum Genet. 1998 Dec;63(6):1598-608. - Pubmed Jose Quiles M, Cuello J: Association of ferredoxin-NADP oxidoreductase with the chloroplastic pyridine nucleotide dehydrogenase complex in barley leaves Plant Physiol. 1998 May;117(1):235-44. - Pubmed
DTHybrid score	1.1026
Cytochrome P450 4A11
Name	Cytochrome P450 4A11
Gene Name	CYP4A11
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed Ngo S, Kong S, Kirlich A, McKinnon RA, Stupans I: Cytochrome P450 4A, peroxisomal enzymes and nicotinamide cofactors in koala liver. Comp Biochem Physiol C Toxicol Pharmacol. 2000 Dec;127(3):327-34. - Pubmed
DTHybrid score	0.6235
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial
Name	Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial
Gene Name	DLAT
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed Shi S, Ehrt S: Dihydrolipoamide acyltransferase is critical for Mycobacterium tuberculosis pathogenesis. Infect Immun. 2006 Jan;74(1):56-63. - Pubmed
DTHybrid score	0.9451
Aminomethyltransferase, mitochondrial
Name	Aminomethyltransferase, mitochondrial
Gene Name	AMT
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score	1.0624
C-4 methylsterol oxidase
Name	C-4 methylsterol oxidase
Gene Name	SC4MOL
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score	1.1021
Heme oxygenase 1
Name	Heme oxygenase 1
Gene Name	HMOX1
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed Calo LA, Pagnin E, Davis PA, Sartori M, Semplicini A: Oxidative stress-related factors in Bartter's and Gitelman's syndromes: relevance for angiotensin II signalling. Nephrol Dial Transplant. 2003 Aug;18(8):1518-25. - Pubmed Auclair K, Huang HW, Moenne-Loccoz P, Ortiz de Montellano PR: Cloning and expression of a heme binding protein from the genome of Saccharomyces cerevisiae. Protein Expr Purif. 2003 Apr;28(2):340-9. - Pubmed
DTHybrid score	1.6226
Heme oxygenase 2
Name	Heme oxygenase 2
Gene Name	HMOX2
Pharmacological action	unknown
Actions	Not Available
References	Tanaka M, Ohkubo K, Fukuzumi S: DNA cleavage by UVA irradiation of NADH with dioxygen via radical chain processes. J Phys Chem A. 2006 Sep 28;110(38):11214-8. - Pubmed Goldstone AB, Liochev SI, Fridovich I: Inactivation of copper, zinc superoxide dismutase by H2O2 : mechanism of protection. Free Radic Biol Med. 2006 Dec 15;41(12):1860-3. Epub 2006 Sep 19. - Pubmed
DTHybrid score	1.1022
Cytochrome P450 17A1
Name	Cytochrome P450 17A1
Gene Name	CYP17A1
Pharmacological action	unknown
Actions	Not Available
References	Pandey AV, Kempna P, Hofer G, Mullis PE, Fluck CE: Modulation of Human CYP19A1 Activity by Mutant NADPH P450 Oxidoreductase. Mol Endocrinol. 2007 Oct;21(10):2579-95. Epub 2007 Jun 26. - Pubmed
DTHybrid score	0.685
Tyrosinase
Name	Tyrosinase
Gene Name	TYR
Pharmacological action	unknown
Actions	Not Available
References	Jadhav JP, Parshetti GK, Kalme SD, Govindwar SP: Decolourization of azo dye methyl red by Saccharomyces cerevisiae MTCC 463. Chemosphere. 2007 Jun;68(2):394-400. Epub 2007 Feb 9. - Pubmed Zafar KS, Siegel D, Ross D: A potential role for cyclized quinones derived from dopamine, DOPA, and 3,4-dihydroxyphenylacetic acid in proteasomal inhibition. Mol Pharmacol. 2006 Sep;70(3):1079-86. Epub 2006 Jun 21. - Pubmed
DTHybrid score	1.1958

Xanthine dehydrogenase/oxidase
Name	Xanthine dehydrogenase/oxidase
Gene Name	XDH
Actions	substrate
References	Kalimuthu P, Leimkuhler S, Bernhardt PV: Xanthine dehydrogenase electrocatalysis: autocatalysis and novel activity. J Phys Chem B. 2011 Mar 24;115(11):2655-62. Epub 2011 Mar 1. - Pubmed Al-Gonaiah M, Smith RA, Stone TW: Xanthine oxidase-induced neuronal death via the oxidation of NADH: prevention by micromolar EDTA. Brain Res. 2009 Jul 14;1280:33-42. Epub 2009 May 18. - Pubmed
DTHybrid score	0.942
Aldehyde oxidase
Name	Aldehyde oxidase
Gene Name	AOX1
Actions	substrate
References	Mantle D, Preedy VR: Free radicals as mediators of alcohol toxicity. Adverse Drug React Toxicol Rev. 1999 Nov;18(4):235-52. - Pubmed Li H, Kundu TK, Zweier JL: Characterization of the magnitude and mechanism of aldehyde oxidase-mediated nitric oxide production from nitrite. J Biol Chem. 2009 Dec 4;284(49):33850-8. Epub 2009 Sep 28. - Pubmed
DTHybrid score	0.7222
Alcohol dehydrogenase 6
Name	Alcohol dehydrogenase 6
Gene Name	ADH6
Actions	substrate,activator
References	Plapp BV: Conformational changes and catalysis by alcohol dehydrogenase. Arch Biochem Biophys. 2010 Jan 1;493(1):3-12. Epub 2009 Jul 5. - Pubmed
DTHybrid score	1.2701
Alcohol dehydrogenase [NADP+]
Name	Alcohol dehydrogenase [NADP+]
Gene Name	AKR1A1
Actions	substrate
References	Plapp BV: Conformational changes and catalysis by alcohol dehydrogenase. Arch Biochem Biophys. 2010 Jan 1;493(1):3-12. Epub 2009 Jul 5. - Pubmed
DTHybrid score	1.0638
Alcohol dehydrogenase 1A
Name	Alcohol dehydrogenase 1A
Gene Name	ADH1A
Actions	substrate
References	Plapp BV: Conformational changes and catalysis by alcohol dehydrogenase. Arch Biochem Biophys. 2010 Jan 1;493(1):3-12. Epub 2009 Jul 5. - Pubmed
DTHybrid score	1.2341
Alcohol dehydrogenase 1B
Name	Alcohol dehydrogenase 1B
Gene Name	ADH1B
Actions	substrate
References	Plapp BV: Conformational changes and catalysis by alcohol dehydrogenase. Arch Biochem Biophys. 2010 Jan 1;493(1):3-12. Epub 2009 Jul 5. - Pubmed
DTHybrid score	1.4443
Alcohol dehydrogenase 4
Name	Alcohol dehydrogenase 4
Gene Name	ADH4
Actions	substrate
References	Plapp BV: Conformational changes and catalysis by alcohol dehydrogenase. Arch Biochem Biophys. 2010 Jan 1;493(1):3-12. Epub 2009 Jul 5. - Pubmed
DTHybrid score	1.2564
Alcohol dehydrogenase class 3
Name	Alcohol dehydrogenase class 3
Gene Name	ADH5
Actions	substrate
References	Plapp BV: Conformational changes and catalysis by alcohol dehydrogenase. Arch Biochem Biophys. 2010 Jan 1;493(1):3-12. Epub 2009 Jul 5. - Pubmed
DTHybrid score	1.7082
Alcohol dehydrogenase class 4 mu/sigma chain
Name	Alcohol dehydrogenase class 4 mu/sigma chain
Gene Name	ADH7
Actions	substrate
References	Plapp BV: Conformational changes and catalysis by alcohol dehydrogenase. Arch Biochem Biophys. 2010 Jan 1;493(1):3-12. Epub 2009 Jul 5. - Pubmed
DTHybrid score	1.089

Id	Partner name	Gene Name	Score
3391	Heme oxygenase 1	pbsA1	1.6226
2381	Dihydrofolate reductase	DFR1	1.5023
2833	Dihydrofolate reductase	Not Available	1.5023
2931	Dihydrofolate reductase	folA	1.5023
3544	Dihydrofolate reductase	folA	1.5023
3682	Dihydrofolate reductase	folA	1.5023
6642	Dihydrofolate reductase	folA	1.5023
6756	Dihydrofolate reductase	dfrA	1.5023
4426	Glyceraldehyde-3-phosphate dehydrogenase	gap	1.4229
4454	Glyceraldehyde-3-phosphate dehydrogenase	gap	1.4229
4489	Glyceraldehyde-3-phosphate dehydrogenase	gap	1.4229
4982	Heme oxygenase 2	pbsA2	1.1022
3463	GDP-L-fucose synthetase	fcl	1.1021
3672	UDP-glucose 6-dehydrogenase	hasB	1.1017
3726	D-3-phosphoglycerate dehydrogenase	serA	1.1017
4291	D-3-phosphoglycerate dehydrogenase	serA	1.1017
3387	3-hydroxy-3-methylglutaryl-coenzyme A reductase	mvaA	0.8699
4512	Cytochrome P450 3A4	CYP3A4	0.297
2799	Glyceraldehyde-3-phosphate dehydrogenase, glycosomal	Not Available	0.2747
6862	Aldo-keto reductase family 1 member B10	AKR1B10	0.2729
1735	Canalicular multispecific organic anion transporter 1	ABCC2	0.2421
6839	[Pyruvate dehydrogenase [lipoamide]] kinase isozyme 3, mitochondrial	PDK3	0.24
6022	UDP-glucuronosyltransferase 1-1	UGT1A1	0.2349
2424	L-lactate dehydrogenase	ldh	0.2267
2641	L-lactate dehydrogenase	Not Available	0.2267
4437	L-lactate dehydrogenase	ldh	0.2267
4442	L-lactate dehydrogenase	ldh	0.2267
4484	2,5-diketo-D-gluconic acid reductase A	dkgA	0.2085
2972	6-deoxyerythronolide B hydroxylase	eryF	0.1986
2290	ADP-ribosyl cyclase 2	BST1	0.1947
6013	Cytochrome P450 2E1	CYP2E1	0.1912
6315	V-type proton ATPase subunit B, brain isoform	ATP6V1B2	0.1877
4757	Cytochrome P450 2C9	CYP2C9	0.1821
4589	3-hydroxy-3-methylglutaryl CoA synthase	mvaS	0.1782
2831	3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase	Not Available	0.1756
3059	3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase	fabG3	0.1756
5003	Acyl-CoA dehydrogenase, short-chain specific	Not Available	0.1753
6030	Cytochrome P450 2B6	CYP2B6	0.1718
5325	2,4-dienoyl-CoA reductase, mitochondrial	DECR1	0.1707
4200	Cytochrome P450 1A2	CYP1A2	0.1673
4924	Cytochrome P450 2C8	CYP2C8	0.1672
6024	Cytochrome P450 1A1	CYP1A1	0.167
5766	NAD-dependent deacetylase sirtuin-5	SIRT5	0.1588
1588	Multidrug resistance protein 1	ABCB1	0.1585
4601	HMG-CoA synthase	mvaS	0.156
4119	Cytochrome P450 2D6	CYP2D6	0.155
3411	Cytochrome P450 121	cyp121	0.154
2826	Glucose--fructose oxidoreductase	gfo	0.1515
4574	PROBABLE NAPHTHOATE SYNTHASE MENB	menB	0.1507
4366	Riboflavin kinase/FMN adenylyltransferase	TM_0857	0.1479
136	Estrogen receptor	ESR1	0.1479
2675	Pteridine reductase 1	PTR1	0.1412
367	Serine hydroxymethyltransferase, cytosolic	SHMT1	0.1376
613	Atrial natriuretic peptide receptor A	NPR1	0.1365
4486	Phenol 2-hydroxylase component B	pheA2	0.1354
4477	Dihydrolipoyl dehydrogenase	lpdV	0.1353
5077	Dihydrolipoyl dehydrogenase	Not Available	0.1353
5117	Dihydrolipoyl dehydrogenase	lpd	0.1353
4439	Ferredoxin reductase	bphA4	0.1353
4120	NADPH--cytochrome P450 reductase	POR	0.1352
3082	Aminomethyltransferase	gcvT	0.1337
4423	Levodione reductase	lvr	0.1292
4428	Redox-sensing transcriptional repressor rex	rex	0.1292
4505	Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase	bphB	0.1292
4495	3-oxoacyl-(Acyl carrier protein) reductase	TM_1169	0.1292
4449	ADP-ribosyltransferase	Not Available	0.1291
4336	Glyceraldehyde 3-phosphate dehydrogenase	Not Available	0.1291
4436	Glyceraldehyde 3-phosphate dehydrogenase	tthHB8IM	0.1291
4446	3alpha-hydroxysteroid dehydrogenase/carbonyl reductase	Not Available	0.1291
4472	Glucose 1-dehydrogenase	Not Available	0.1291
4500	L-lactate dehydrogenase 2	ldh2	0.1291
4435	L-aspartate dehydrogenase	nadX	0.1291
4447	Hypothetical protein yhfP	yhfP	0.1291
4443	Quinate/shikimate dehydrogenase	ydiB	0.1291
2350	3-isopropylmalate dehydrogenase	leuB	0.1291
3092	3-isopropylmalate dehydrogenase	leuB	0.1291
4448	L-2-hydroxyisocaproate dehydrogenase	Not Available	0.1291
4414	Dehydrogenase	TT_P0035	0.1291
4456	Inorganic polyphosphate/ATP-NAD kinase	ppnK	0.1291
4455	Glycerol dehydrogenase	gldA	0.1291
4497	Benzyl alcohol dehydrogenase	xylB	0.1291
4466	Glutathione-independent formaldehyde dehydrogenase	fdhA	0.1291
4418	AGR_L_3209p	AGR_L_3209	0.1291
4507	Alanine dehydrogenase	ald	0.1291
3735	NAD(P) transhydrogenase subunit alpha part 1	pntAA	0.1291
4475	Hypothetical protein Rv0046c/MT0052	ino1	0.1291
4506	Myo-inositol-1-phosphate synthase-related protein	TM_1419	0.1291
4471	CDP-D-glucose-4,6-dehydratase	ascB	0.1291
3729	Citrate synthase	gltA	0.1291
4575	Citrate synthase	cit	0.1291
4580	Citrate synthase	gltA	0.1291
4502	Formate dehydrogenase	Not Available	0.1291
4451	Vip2Ac	vip2Ac	0.1291
4487	Transcriptional regulator nadR	nadR	0.1291
4467	Alpha-glucosidase, putative	TM_0752	0.1291
327	Glutathione reductase	gor	0.129
5110	Glutathione reductase	GR2	0.129
1732	ATP-binding cassette sub-family G member 2	ABCG2	0.1288
76	Nitric-oxide synthase, brain	NOS1	0.1265
4498	Ornithine cyclodeaminase	PP3533	0.1233
6840	Virulence sensor histidine kinase phoQ	phoQ	0.1231
5073	Ferredoxin--NADP reductase	petH	0.1225
5076	Ferredoxin--NADP reductase	fpr	0.1225
5119	Ferredoxin--NADP reductase	petH	0.1225
5121	Ferredoxin--NADP reductase	fpr	0.1225
5075	Sulfite reductase [NADPH] flavoprotein alpha-component	cysJ	0.1224
5718	Cytochrome P450 2A6	CYP2A6	0.1218
2297	Genome polyprotein	Not Available	0.1215
2322	Genome polyprotein	Not Available	0.1215
2694	Genome polyprotein	Not Available	0.1215
2719	Genome polyprotein	Not Available	0.1215
2860	Genome polyprotein	Not Available	0.1215
2928	Genome polyprotein	Not Available	0.1215
3160	Genome polyprotein	Not Available	0.1215
3260	Genome polyprotein	Not Available	0.1215
4783	Genome polyprotein	Not Available	0.1215
5726	Genome polyprotein	Not Available	0.1215
5779	Genome polyprotein	Not Available	0.1215
5867	Genome polyprotein	Not Available	0.1215
6253	Genome polyprotein	Not Available	0.1215
6301	Genome polyprotein	Not Available	0.1215
6380	Genome polyprotein	Not Available	0.1215
6381	Genome polyprotein	Not Available	0.1215
6437	Genome polyprotein	Not Available	0.1215
6520	Genome polyprotein	Not Available	0.1215
6521	Genome polyprotein	Not Available	0.1215
6652	Genome polyprotein	Not Available	0.1215
6734	Genome polyprotein	Not Available	0.1215
6735	Genome polyprotein	Not Available	0.1215
6736	Genome polyprotein	Not Available	0.1215
6737	Genome polyprotein	Not Available	0.1215
6738	Genome polyprotein	Not Available	0.1215
6739	Genome polyprotein	Not Available	0.1215
6744	Genome polyprotein	Not Available	0.1215
6748	Genome polyprotein	Not Available	0.1215
6894	Genome polyprotein	Not Available	0.1215
6898	Genome polyprotein	Not Available	0.1215
4440	NADH peroxidase	npr	0.12
126	D-lactate dehydrogenase	dld	0.1196
3545	D-lactate dehydrogenase	Not Available	0.1196
4510	D-lactate dehydrogenase	ldhA	0.1196
1124	Sepiapterin reductase	SPR	0.119
6178	UDP-glucuronosyltransferase 2B7	UGT2B7	0.1187
1898	Cytochrome P450 1B1	CYP1B1	0.1186
869	Estrogen receptor beta	ESR2	0.1179
3087	Nicotinate-nucleotide adenylyltransferase	nadD	0.1171
4469	Nicotinate-nucleotide adenylyltransferase	nadD	0.1171
2538	6-phospho-beta-glucosidase bglT	bglT	0.116
2393	Maltose-6'-phosphate glucosidase	glvA	0.116
63	Malate dehydrogenase	mdh	0.1137
2329	Malate dehydrogenase	mdh	0.1137
3445	Malate dehydrogenase	mdh	0.1137
4420	Malate dehydrogenase	mdh	0.1137
4438	Malate dehydrogenase	mdh	0.1137
3191	Histidinol dehydrogenase	hisD	0.1129
2636	Shikimate dehydrogenase	aroE	0.1123
3515	Shikimate dehydrogenase	aroE	0.1123
3178	Formate acetyltransferase 1	pflB	0.112
6172	ATP-binding cassette sub-family B member 8, mitochondrial	ABCB8	0.112
4503	NADPH-flavin oxidoreductase	frp	0.1117
3736	Glyceraldehyde-3-phosphate dehydrogenase A	gapA	0.1115
589	Retinoid-binding protein 7	RBP7	0.1113
753	Retinol-binding protein III, cellular	RBP5	0.1112
561	Retinol-binding protein II, cellular	RBP2	0.1112
4075	Photoreceptor outer segment all-trans retinol dehydrogenase	RDH8	0.1112
1097	Lecithin retinol acyltransferase	LRAT	0.1112
4054	Glycine cleavage system H protein, mitochondrial	GCSH	0.1112
4071	Short-chain dehydrogenase/reductase 3	DHRS3	0.1112
651	Retinol dehydrogenase 13	RDH13	0.1112
4073	Retinol dehydrogenase 11	RDH11	0.1112
800	Retinol dehydrogenase 12	RDH12	0.1112
863	Cellular retinaldehyde-binding protein	RLBP1	0.1112
35	Dehydrogenase/reductase SDR family member 4	DHRS4	0.1112
4074	Retinol dehydrogenase 14	RDH14	0.1111
4072	All-trans-retinol 13,14-reductase	RETSAT	0.1111
282	Interphotoreceptor retinoid-binding protein	RBP3	0.111
5346	Oxidoreductase, aldo/keto reductase family	TM_1009	0.1102
3772	3-oxoacyl-[acyl-carrier-protein] reductase	fabG	0.1102
5157	Dehydrogenase/reductase SDR family member 11	DHRS11	0.1102
5326	Oxidoreductase, short chain dehydrogenase/reductase family	TM_0441	0.1102
5332	MtdA bifunctional protein	mtdA	0.1102
4403	Protein iolS	iolS	0.1102
3778	NAD(P) transhydrogenase subunit beta	pntB	0.1102
5330	General stress protein 69	yhdN	0.1102
5322	Oxidoreductase ydhF	ydhF	0.1102
5333	Alcohol dehydrogenase, iron-containing	TM_0920	0.1101
5342	NADH-dependent butanol dehydrogenase, putative	TM_0820	0.1101
5343	NADP-dependent fatty aldehyde dehydrogenase	aldH	0.1101
1649	Small inducible cytokine A2	CCL2	0.11
3573	2,4-dienoyl-CoA reductase [NADPH]	fadH	0.1094
2596	Acetyl-CoA acetyltransferase	phbA	0.1093
4496	C-terminal-binding protein 1	CTBP1	0.1081
500	Monocarboxylate transporter 4	SLC16A3	0.1074
3598	dTDP-4-dehydrorhamnose reductase	rfbD	0.107
4427	TDP-glucose-4,6-dehydratase	desIV	0.1069
3177	dTDP-glucose 4,6-dehydratase	rfbB	0.1069
4499	dTDP-glucose 4,6-dehydratase	rmlB	0.1069
2967	CDP-paratose 2-epimerase	rfbE	0.1063
4482	UDP-galactose 4-epimerase	galE	0.1063
2230	Catalase	CAT	0.1063
3249	Catalase	katA	0.1063
3625	Catalase	katA	0.1063
4539	Catalase	katA	0.1063
4941	Catalase	katB	0.1063
2507	Diphtheria toxin	Not Available	0.1053
5328	Prostaglandin F synthase	Tb11.02.2310	0.1052
482	Glycine receptor subunit alpha-1	GLRA1	0.1046
4509	Acetoin(diacetyl) reductase	budC	0.1045
3081	3-dehydroquinate synthase	aroB	0.1042
558	Solute carrier family 12 member 1	SLC12A1	0.1042
2591	Urocanate hydratase	hutU	0.1041
3671	7-alpha-hydroxysteroid dehydrogenase	hdhA	0.1039
3615	Dihydrodipicolinate reductase	dapB	0.1038
3618	Dihydrodipicolinate reductase	dapB	0.1038
4462	Dihydrodipicolinate reductase	dapB	0.1038
4450	Iota toxin component Ia	Not Available	0.1038
6698	Dehydrogenase/reductase SDR family member 4-like 2	DHRS4L2	0.1037
1199	GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1	ART1	0.1037
3401	D-2-hydroxyisocaproate dehydrogenase	Not Available	0.1036
2336	2,3-diketo-L-gulonate reductase	dlgD	0.1035
2018	Deoxyhypusine synthase	DHPS	0.1034
2881	Gamma-aminobutyraldehyde dehydrogenase	prr	0.1034
6018	UDP-glucuronosyltransferase 1-9	UGT1A9	0.1033
2683	Mono-ADP-ribosyltransferase C3	C3	0.1022
4118	Cytochrome P450 3A5	CYP3A5	0.1008
6016	Cytochrome P450 2C19	CYP2C19	0.1001
59	AMT protein	AMT	0.0989
2157	NAD(P)H dehydrogenase [quinone] 1	NQO1	0.098
945	Adrenocorticotropic hormone receptor	MC2R	0.0978
4504	WbpP	Not Available	0.0971
4476	Mannitol dehydrogenase	mtlD	0.0969
3296	Nicotinamide mononucleotide adenylyltransferase 1	NMNAT1	0.0969
2375	ADP-L-glycero-D-manno-heptose-6-epimerase	hldD	0.0965
776	Bile salt export pump	ABCB11	0.0964
6236	Trimethoprim-sensitive dihydrofolate reductase	dfrB	0.0961
3367	GDP-mannose 6-dehydrogenase	algD	0.096
4318	Siroheme synthase	cysG	0.0947
587	Serum albumin	ALB	0.0946
4343	Alpha-glucosidase	aglA	0.0932
4582	Putative pteridine reductase 2	ptr2	0.0929
3920	Methylenetetrahydrofolate reductase intermediate form	MTHFR	0.0928
4628	NADP-dependent glyceraldehyde-3-phosphate dehydrogenase	gapN	0.0928
3919	Methionyl-tRNA formyltransferase, mitochondrial	MTFMT	0.0927
1202	10-formyltetrahydrofolate dehydrogenase	ALDH1L1	0.0927
989	L-xylulose reductase	DCXR	0.0926
605	Fumarate reductase flavoprotein subunit	frdA	0.0923
2709	Fumarate reductase flavoprotein subunit	SO_0970	0.0923
3673	Fumarate reductase flavoprotein subunit	fccA	0.0923
4912	Fumarate reductase flavoprotein subunit	ifcA	0.0923
6549	Fumarate reductase flavoprotein subunit	frdA	0.0923
2305	Isocitrate dehydrogenase [NADP] cytoplasmic	IDH1	0.0921
1799	Glucose-6-phosphate 1-dehydrogenase	G6PD	0.0921
2630	Glucose-6-phosphate 1-dehydrogenase	zwf	0.0921
3446	NADP-dependent alcohol dehydrogenase	adh	0.0921
2286	Isocitrate dehydrogenase [NADP]	icd	0.0921
2302	Isocitrate dehydrogenase [NADP]	icd	0.0921
2771	Isocitrate dehydrogenase [NADP]	icd	0.0921
6168	Solute carrier family 22 member 16	SLC22A16	0.0916
705	Glutamate receptor 1	GRIA1	0.0911
3999	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	SDHD	0.0909
3917	Methylenetetrahydrofolate reductase	MTHFR	0.0905
3333	Nicotinamide mononucleotide adenylyltransferase 3	NMNAT3	0.0904
2434	NH(3)-dependent NAD(+) synthetase	nadE	0.0902
2910	NH(3)-dependent NAD(+) synthetase	nadE	0.0902
3217	NH(3)-dependent NAD(+) synthetase	nadE	0.0902
3070	Adenosylhomocysteinase	AHCY	0.0891
4424	Adenosylhomocysteinase	PFE1050w	0.0891
6278	Adenosylhomocysteinase	ahcY	0.0891
241	Calcium-transporting ATPase type 2C member 1	ATP2C1	0.0887
331	Retinol-binding protein I, cellular	RBP1	0.0886
4531	Putative ketoacyl reductase	actIII	0.0882
537	ATP synthase delta chain, mitochondrial	ATP5D	0.0876
6297	Prostaglandin reductase 1	PTGR1	0.0842
3062	Aspartate-semialdehyde dehydrogenase	asd	0.084
2091	Endoplasmin	HSP90B1	0.0834
6142	Solute carrier family 22 member 8	SLC22A8	0.0831
2936	Oxygen-insensitive NAD(P)H nitroreductase	nfnB	0.0822
5184	Oxygen-insensitive NAD(P)H nitroreductase	nfnB	0.0822
2159	Quinone oxidoreductase	CRYZ	0.0813
4087	Pyrroline 5-carboxylate reductase isoform	P5CR2	0.0802
526	Thioredoxin reductase	trxB	0.0798
3767	Thioredoxin reductase	trxB	0.0798
6151	Monocarboxylate transporter 10	SLC16A10	0.0797
2762	UDP-glucose 4-epimerase	GALE	0.0795
3461	UDP-glucose 4-epimerase	galE	0.0795
4491	DNA ligase, NAD-dependent	ligA	0.0794
3456	Heat shock protein HSP 90-beta	HSP90AB1	0.0774
862	Multidrug resistance-associated protein 1	ABCC1	0.0768
872	Gamma-aminobutyric-acid receptor subunit alpha-1	GABRA1	0.0767
914	Formimidoyltransferase-cyclodeaminase	FTCD	0.0766
6143	Solute carrier family 22 member 7	SLC22A7	0.0762
578	Endothelin-1 receptor	EDNRA	0.0761
345	Plasma retinol-binding protein	RBP4	0.0757
1729	Solute carrier family 22 member 6	SLC22A6	0.0747
6139	Solute carrier organic anion transporter family member 1A2	SLCO1A2	0.0744
3610	Thioredoxin reductase 1, cytoplasmic	TXNRD1	0.0743
373	Transthyretin	TTR	0.0737
2165	Glutathione S-transferase Mu 2	GSTM2	0.0736
4604	Liver carboxylesterase 1	CES1	0.0728
20	Prostaglandin G/H synthase 1	PTGS1	0.0724
5934	Cytochrome P450 26A1	CYP26A1	0.0723
4084	Peptidyl-prolyl cis-trans isomerase B	PPIB	0.0722
2287	Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase	ATIC	0.0719
1566	Corticoliberin	CRH	0.0717
6106	Cytochrome P450 2C18	CYP2C18	0.0716
4083	Peptidyl-prolyl cis-trans isomerase H	PPIH	0.0707
4082	Proline oxidase, mitochondrial	PRODH	0.0707
4090	Chromosome 14 open reading frame 149	C14orf149	0.0707
4085	Peptidyl-prolyl cis-trans isomerase C	PPIC	0.0707
4088	Probable prolyl-tRNA synthetase, mitochondrial	PARS2	0.0706
4086	Peptidyl-prolyl cis-trans isomerase G	PPIG	0.0706
797	Sodium-dependent proline transporter	SLC6A7	0.0706
858	Potassium voltage-gated channel subfamily A member 1	KCNA1	0.0703
1302	Dihydropyrimidine dehydrogenase [NADP+]	DPYD	0.0692
6137	Multidrug resistance-associated protein 6	ABCC6	0.0692
4000	Prolyl 4-hydroxylase subunit alpha-2	P4HA2	0.069
738	Monocarboxylate transporter 1	SLC16A1	0.0688
493	25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	CYP27B1	0.0683
6107	Cytochrome P450 3A7	CYP3A7	0.0683
3486	Fumarate hydratase class II	fumC	0.0679
553	DNA polymerase I	polA	0.0664
6373	DNA polymerase I	polA	0.0664
2891	Circadian clock protein kaiB	kaiB	0.0659
1709	Canalicular multispecific organic anion transporter 2	ABCC3	0.0649
5251	Carbonyl reductase [NADPH] 1	CBR1	0.0643
2248	Malate synthase G	glcB	0.0642
3190	Malate synthase G	glcB	0.0642
368	Enoyl-[acyl-carrier-protein] reductase [NADH]	inhA	0.064
3228	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.064
3678	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.064
6856	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.064
3884	SHMT2 protein	SHMT2	0.0622
3901	SHMT2 protein	SHMT2	0.0622
3885	Hypothetical protein DKFZp686P09201	DKFZp686P09201	0.0622
3879	Serine hydroxymethyltransferase 2	Not Available	0.0622
321	Serine hydroxymethyltransferase, mitochondrial	SHMT2	0.0622
6148	Multidrug resistance-associated protein 7	ABCC10	0.0616
280	4-aminobutyrate aminotransferase, mitochondrial	ABAT	0.0616
3997	Cytochrome P450 24A1, mitochondrial	CYP24A1	0.0611
4384	Capsule biosynthesis protein	synC	0.0608
290	Prostaglandin G/H synthase 2	PTGS2	0.0606
3949	Prolyl 3-hydroxylase 2	LEPREL1	0.0598
3945	Prolyl 3-hydroxylase 1	LEPRE1	0.0597
3951	Prolyl 3-hydroxylase 3	LEPREL2	0.0597
2268	Cholesterol oxidase	choB	0.0592
2822	Cholesterol oxidase	choA	0.0592
210	Bifunctional aminoacyl-tRNA synthetase [Includes: Glutamyl-tRNA synthetase	EPRS	0.0586
291	Nitric-oxide synthase, endothelial	NOS3	0.0583
186	Glutamate--cysteine ligase catalytic subunit	GCLC	0.0581
668	Glutamate--cysteine ligase regulatory subunit	GCLM	0.0581
642	3-oxo-5-alpha-steroid 4-dehydrogenase 2	SRD5A2	0.0576
171	Cysteine dioxygenase	CDO-1	0.0575
809	Methionine synthase	MTR	0.0574
2935	Methionine synthase	metH	0.0574
3811	Cytochrome P450 19A1	CYP19A1	0.0568
24	Thymidylate synthase	TMP1	0.055
359	Thymidylate synthase	TYMS	0.055
2626	Thymidylate synthase	thyA	0.055
2729	Thymidylate synthase	thyA	0.055
5352	Thymidylate synthase	THYA	0.055
1490	Solute carrier organic anion transporter family member 1B1	SLCO1B1	0.0549
67	Prolyl 4-hydroxylase subunit alpha-1	P4HA1	0.0548
84	Nuclear receptor 0B1	NR0B1	0.0547
3874	Proline synthetase co-transcribed bacterial homolog protein	PROSC	0.0542
7	Nitric oxide synthase, inducible	NOS2	0.0542
817	DNA topoisomerase 2-alpha	TOP2A	0.0542
2769	P-hydroxybenzoate hydroxylase	pobA	0.0538
2809	P-hydroxybenzoate hydroxylase	pobA	0.0538
6105	3-oxo-5-beta-steroid 4-dehydrogenase	AKR1D1	0.0531
408	Riboflavin kinase	RFK	0.0524
4064	Probable cysteinyl-tRNA synthetase, mitochondrial	CARS2	0.0518
774	Cysteinyl-tRNA synthetase, cytoplasmic	CARS	0.0518
1314	Thiamine transporter 2	SLC19A3	0.0518
719	Retinoic acid receptor responder protein 1	RARRES1	0.0518
770	Retinoic acid-induced protein 3	GPRC5A	0.0518
1758	GTPase HRas	HRAS	0.0515
737	Mineralocorticoid receptor	NR3C2	0.0514
146	Androgen receptor	AR	0.0504
3381	Alcohol dehydrogenase	Not Available	0.049
4508	Alcohol dehydrogenase	adhA	0.049
1374	Natriuretic peptides B	NPPB	0.0489
397	Monocarboxylate transporter 3	SLC16A8	0.0489
1827	Gap junction alpha-1 protein	GJA1	0.0488
1908	Vascular cell adhesion protein 1	VCAM1	0.0488
218	Monocarboxylate transporter 5	SLC16A4	0.0488
429	Monocarboxylate transporter 6	SLC16A5	0.0488
195	Monocarboxylate transporter 7	SLC16A6	0.0488
2222	Equilibrative nucleoside transporter 1	SLC29A1	0.0485
6177	UDP-glucuronosyltransferase 1-10	UGT1A10	0.0477
6181	UDP-glucuronosyltransferase 1-8	UGT1A8	0.0474
614	Progesterone receptor	PGR	0.0472
2554	Peptidyl-prolyl cis-trans isomerase, mitochondrial	PPIF	0.0471
6032	PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE)	fas	0.0471
3404	Exotoxin A	eta	0.0471
2164	Multidrug resistance-associated protein 4	ABCC4	0.0468
471	Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+)	SLC6A14	0.0465
1050	Bile salt sulfotransferase	SULT2A1	0.0465
5698	Riboflavin synthase alpha chain	ribE	0.0462
4593	ADP compounds hydrolase nudE	nudE	0.0461
6171	Solute carrier family 28 member 3	SLC28A3	0.0459
1039	Histone deacetylase 9	HDAC9	0.0458
586	Aspartate aminotransferase, cytoplasmic	GOT1	0.0452
1757	Myeloperoxidase	MPO	0.0437
6157	Solute carrier organic anion transporter family member 1B3	SLCO1B3	0.0432
6023	Cytochrome P450 11B2, mitochondrial	CYP11B2	0.0429
6017	Cholesterol side-chain cleavage enzyme, mitochondrial	CYP11A1	0.0427
311	RNA-directed RNA polymerase catalytic subunit	PB1	0.0426
752	Large structural protein	L	0.0426
1524	Peptidyl-prolyl cis-trans isomerase A	PPIA	0.0425
6700	Peptidyl-prolyl cis-trans isomerase A	ppiA	0.0425
6141	Sodium/bile acid cotransporter	SLC10A1	0.042
1632	Solute carrier organic anion transporter family member 2B1	SLCO2B1	0.0419
756	Sex hormone-binding globulin	SHBG	0.041
706	Glutamate [NMDA] receptor subunit 3A	GRIN3A	0.0405
773	Folylpolyglutamate synthase, mitochondrial	FPGS	0.0404
207	Glutathione synthetase	GSS	0.0402
5269	Glutathione synthetase	gshB	0.0402
89	Cysteine sulfinic acid decarboxylase	CSAD	0.0398
3108	CDP-glucose 4,6-dehydratase	rfbG	0.0397
6176	UDP-glucuronosyltransferase 1-3	UGT1A3	0.0395
2460	ADP-ribose pyrophosphatase	nudF	0.0395
4349	ADP-ribose pyrophosphatase	ndx4	0.0395
118	Organic cation/carnitine transporter 2	SLC22A5	0.0392
1999	Methylated-DNA--protein-cysteine methyltransferase	MGMT	0.039
3725	Lactaldehyde reductase	fucO	0.0389
4131	Prostaglandin E2 receptor, EP3 subtype	PTGER3	0.0386
1650	Heme carrier protein 1	SLC46A1	0.0382
6140	Ileal sodium/bile acid cotransporter	SLC10A2	0.0381
3978	Adenylosuccinate synthetase isozyme 1	ADSSL1	0.0379
630	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial	ACADSB	0.0378
723	Cytosolic phospholipase A2	PLA2G4A	0.0378
169	Cysteine desulfurase, mitochondrial	NFS1	0.0376
358	Cystathionine beta-synthase	CBS	0.0375
672	Prostaglandin F2-alpha receptor	PTGFR	0.0371
289	Cytosolic purine 5'-nucleotidase	NT5C2	0.0371
564	Cellular retinoic acid-binding protein 1	CRABP1	0.037
859	Cellular retinoic acid-binding protein 2	CRABP2	0.0359
805	Cytochrome P450 11B1, mitochondrial	CYP11B1	0.0355
3719	Inosine-5'-monophosphate dehydrogenase	guaB	0.0353
3799	Hypoxanthine phosphoribosyltransferase	hpt	0.0353
820	Glycine receptor subunit alpha-2	GLRA2	0.0352
3941	Amine oxidase [flavin-containing] A	MAOA	0.0345
2353	Apolipoprotein(a)	LPA	0.0343
508	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	ENPP1	0.0341
52	Pyruvate kinase isozymes R/L	PKLR	0.034
904	Glutathione S-transferase P	GSTP1	0.0338
6790	Elongation factor 2	EEF2	0.0337
73	Prostaglandin E2 receptor, EP1 subtype	PTGER1	0.0335
3126	Poly [ADP-ribose] polymerase 1	PARP1	0.0331
771	Pyruvate carboxylase, mitochondrial	PC	0.0331
780	Retinoic acid receptor RXR-gamma	RXRG	0.033
3085	Molybdopterin-guanine dinucleotide biosynthesis protein A	mobA	0.0325
5599	3-carboxy-cis,cis-muconate cycloisomerase	pcaB	0.0319
6068	Guanylate cyclase soluble subunit alpha-2	GUCY1A2	0.0316
868	Cystathionine gamma-lyase	CTH	0.0315
3932	Glutathione S-transferase A2	GSTA2	0.0314
114	Alanine--glyoxylate aminotransferase 2, mitochondrial	AGXT2	0.0312
5114	Putative acyl-CoA dehydrogenase	TT_C0779	0.0309
5109	Outer membrane protein p64k or PM-6	m-6	0.0309
5122	Mersacidin decarboxylase	mrsD	0.0309
5078	Amine oxidase, flavin-containing	PSPTO1126	0.0309
5112	Benzoate 1,2-dioxygenase electron transfer component	benC	0.0309
3763	5,10-methylenetetrahydrofolate reductase	metF	0.0309
3918	5,10-methylenetetrahydrofolate reductase	MTHFR	0.0309
5094	5,10-methylenetetrahydrofolate reductase	metF	0.0309
5095	Putidaredoxin reductase	camA	0.0309
5115	FkbI	fkbI	0.0309
3133	UDP-galactopyranose mutase	glf	0.0309
5099	UDP-galactopyranose mutase	glf	0.0309
5102	4-cresol dehydrogenase [hydroxylating] flavoprotein subunit	pchF	0.0309
5100	Gamma-aminobutyrate metabolism dehydratase/isomerase	abfD	0.0309
5083	Cryptochrome DASH	cry	0.0309
5081	L-aspartate oxidase	nadB	0.0309
1329	Apoptosis-inducing factor 1, mitochondrial	AIFM1	0.0309
5107	Alkyl hydroperoxide reductase subunit F	ahpF	0.0309
5118	Alkyl hydroperoxide reductase subunit F	ahpF	0.0309
5097	PROBABLE DIHYDROLIPOAMIDE DEHYDROGENASE LPDA	lpdA	0.0309
5111	Phenylacetone monooxygenase	pamO	0.0309
183	Vascular endothelial growth factor A	VEGFA	0.0309
234	Plasminogen	PLG	0.0306
2283	Steroid Delta-isomerase	ksi	0.0305
2920	Steroid Delta-isomerase	ksi	0.0305
6021	Adenosine kinase	ADK	0.0299
448	Vitamin K-dependent gamma-carboxylase	GGCX	0.0289
4269	Hypoxanthine-guanine phosphoribosyltransferase, putative	HGPRTase	0.0288
6136	Multidrug resistance-associated protein 5	ABCC5	0.0288
6228	Nuclear receptor coactivator 1	NCOA1	0.0288
6025	UDP-glucuronosyltransferase 1-4	UGT1A4	0.0288
88	Retinoic acid receptor RXR-beta	RXRB	0.0287
2325	Sulfotransferase family cytosolic 2B member 1	SULT2B1	0.0286
1405	Thiopurine S-methyltransferase	TPMT	0.028
162	Retinoic acid receptor gamma-1	RARG	0.0278
3923	Cholinesterase	BCHE	0.0278
87	Hypoxanthine-guanine phosphoribosyltransferase	HPRT1	0.0277
98	Pyruvate kinase isozymes M1/M2	PKM2	0.0277
199	Monocarboxylate transporter 8	SLC16A2	0.0276
2526	NADPH-ferredoxin reductase fprA	fprA	0.027
3102	Flavohemoprotein	hmp	0.0269
4969	Flavohemoprotein	hmp	0.0269
1792	Tissue-type plasminogen activator	PLAT	0.0268
440	Isovaleryl-CoA dehydrogenase, mitochondrial	IVD	0.0268
667	Acyl-CoA dehydrogenase family member 8, mitochondrial	ACAD8	0.0268
3506	Glutaryl-CoA dehydrogenase, mitochondrial	GCDH	0.0268
2470	Pyruvate oxidase	pox5	0.0263
3594	Deoxyribodipyrimidine photo-lyase	phr	0.0262
5079	Deoxyribodipyrimidine photo-lyase	phrB	0.0262
5080	Deoxyribodipyrimidine photo-lyase	phr	0.0262
5072	N,N-dimethylglycine oxidase	dmg	0.0262
6152	Solute carrier organic anion transporter family member 2A1	SLCO2A1	0.0261
5091	UDP-N-acetylenolpyruvoylglucosamine reductase	murB	0.0261
5093	UDP-N-acetylenolpyruvoylglucosamine reductase	murB	0.0261
3247	2-oxopropyl-CoM reductase, carboxylating	xecC	0.0261
6639	Peroxisomal acyl-coenzyme A oxidase 1	ACOX1	0.026
85	Growth hormone receptor	GHR	0.0254
489	Monocarboxylate transporter 2	SLC16A7	0.0252
3185	Medium-chain specific acyl-CoA dehydrogenase, mitochondrial	ACADM	0.0246
338	DNA polymerase	UL30	0.0246
379	DNA polymerase	UL54	0.0246
697	DNA polymerase	ORF28	0.0246
2482	DNA polymerase	43	0.0246
4104	DNA polymerase	BALF5	0.0246
2597	Glucosamine--fructose-6-phosphate aminotransferase [isomerizing]	glmS	0.024
5682	Ribonuclease pancreatic	RNASE1	0.0239
3254	Bifunctional protein putA [Includes: Proline dehydrogenase	putA	0.0238
2893	Glycine oxidase	thiO	0.0238
3317	Holo-[acyl-carrier-protein] synthase	acpS	0.0232
4381	Holo-[acyl-carrier-protein] synthase	acpS	0.0232
3125	Protease synthase and sporulation negative regulatory protein PAI 1	paiA	0.0232
2603	Beta-lactamase II	blm	0.0231
2567	Thymidylate synthase thyX	thyX	0.023
5669	50S ribosomal protein L27	rpmA	0.0227
5670	Organic hydroperoxide resistance protein	ohr	0.0227
5675	Chaperone protein torD	torD	0.0226
5672	Molybdenum cofactor biosynthesis protein A	moaA	0.0226
5410	Unsaturated glucuronyl hydrolase	ugl	0.0226
5673	C protein alpha-antigen	bca	0.0226
5676	Axin-1	AXIN1	0.0226
896	Glutathione S-transferase Mu 1	GSTM1	0.0226
6447	Guanine nucleotide-binding protein G(t) subunit alpha-1	GNAT1	0.0225
1673	GTP cyclohydrolase I	GCH1	0.0225
3302	GTP cyclohydrolase I	folE	0.0225
3209	Ornithine decarboxylase, inducible	odcI	0.0225
153	Dopamine beta-hydroxylase	DBH	0.0223
2823	Trypanothione reductase	TPR	0.0223
94	5-hydroxytryptamine 4 receptor	HTR4	0.0222
6316	ADP-ribosylation factor 1	ARF1	0.0221
2632	Adenylosuccinate synthetase	purA	0.022
3323	Adenylosuccinate synthetase	purA	0.022
3975	Adenylosuccinate synthetase	ADSS	0.022
4598	Adenylosuccinate synthetase	Adss	0.022
6817	Adenylosuccinate synthetase	purA	0.022
909	Maleylacetoacetate isomerase	GSTZ1	0.0219
740	Argininosuccinate synthase	ASS1	0.0219
865	Argininosuccinate synthase	ASS1	0.0219
2680	Argininosuccinate synthase	argG	0.0219
3194	Argininosuccinate synthase	argG	0.0219
101	Potassium voltage-gated channel subfamily H member 2	KCNH2	0.0217
54	Prothrombin	F2	0.0216
5449	Hypothetical gliding protein	mglB	0.0215
5443	UPF0189 protein ymdB	ymdB	0.0215
2720	Copper-containing nitrite reductase	nirK	0.0215
5446	3-deoxy-D-manno-octulosonate 8-phosphate phosphatase	HI_1679	0.0215
5440	UPF0067 protein yebR	yebR	0.0214
4705	Manganese catalase	Not Available	0.0214
5439	33 kDa chaperonin	hslO	0.0214
5448	Ribonuclease Z	rnz	0.0214
3781	Thiol:disulfide interchange protein dsbC precursor	dsbC	0.0214
5447	Lethal(3)malignant brain tumor-like protein	L3MBTL1	0.0214
5454	Internalin-A	inlA	0.0214
1152	Glycogen phosphorylase, muscle form	PYGM	0.0214
4311	tRNA	TRDMT1	0.0213
4325	tRNA	trmD	0.0213
4328	tRNA	trmD	0.0213
4228	Keratin, type II cytoskeletal 7	KRT7	0.0213
5180	L(+)-mandelate dehydrogenase	mdlB	0.0211
400	Coagulation factor IX	F9	0.021
5461	Coagulation factor IX	F9	0.021
3697	Bifunctional protein glmU [Includes: UDP-N-acetylglucosamine pyrophosphorylase	glmU	0.0208
2380	Monomeric sarcosine oxidase	soxA	0.0204
556	Alpha-1A adrenergic receptor	ADRA1A	0.0202
6579	Calcium/calmodulin-dependent protein kinase type II alpha chain	CAMK2A	0.02
620	Bifunctional dihydrofolate reductase-thymidylate synthase	Not Available	0.02
4152	Superoxide dismutase [Cu-Zn]	SOD1	0.0197
3335	Probable GTP-binding protein engB	engB	0.0196
3354	Ras-related protein Rap-2a	RAP2A	0.0196
465	Calmodulin	CALM1	0.0196
6645	D-amino-acid oxidase	DAO	0.0195
3311	mRNA-capping enzyme	A103R	0.0195
4081	Vitamin K epoxide reductase complex subunit 1-like protein 1	VKORC1L1	0.0194
604	Vitamin K-dependent protein Z	PROZ	0.0193
2647	RNA-directed RNA polymerase	P2	0.0193
193	Beta-1 adrenergic receptor	ADRB1	0.0191
4024	Mitochondrial glutamate carrier 2	SLC25A18	0.0188
4025	Mitochondrial glutamate carrier 1	SLC25A22	0.0188
4022	Glutamate--ammonia ligase domain-containing protein 1	LGSN	0.0188
4023	N-acetylglutamate synthase, mitochondrial	NAGS	0.0188
4026	Aspartyl aminopeptidase	DNPEP	0.0188
1912	Excitatory amino acid transporter 1	SLC1A3	0.0188
4016	Excitatory amino acid transporter 5	SLC1A7	0.0188
4019	Excitatory amino acid transporter 4	SLC1A6	0.0188
1047	Excitatory amino acid transporter 2	SLC1A2	0.0188
664	Glutamate decarboxylase 2	GAD2	0.0188
3890	Glutamate decarboxylase 2	GAD2	0.0188
4021	Probable glutamyl-tRNA synthetase, mitochondrial	EARS2	0.0188
915	Delta 1-pyrroline-5-carboxylate synthetase	ALDH18A1	0.0188
4018	Glutamate receptor delta-2 subunit	GRID2	0.0188
927	Metabotropic glutamate receptor 8	GRM8	0.0188
926	Metabotropic glutamate receptor 7	GRM7	0.0188
4027	Glutamate receptor delta-1 subunit	GRID1	0.0188
922	Glutamate receptor 4	GRIA4	0.0188
924	Glutamate receptor, ionotropic kainate 3	GRIK3	0.0188
925	Metabotropic glutamate receptor 4	GRM4	0.0188
4017	5-oxoprolinase	OPLAH	0.0188
919	Glutamate receptor, ionotropic kainate 4	GRIK4	0.0188
4020	Glutamyl aminopeptidase	ENPEP	0.0188
920	Glutamate receptor, ionotropic kainate 5	GRIK5	0.0188
5450	Prolyl endopeptidase Pep	pep	0.0187
610	Calcium-activated potassium channel subunit alpha 1	KCNMA1	0.0187
4771	Dissimilatory copper-containing nitrite reductase	nir	0.0187
3356	Diaminopimelate decarboxylase	lysA	0.0187
766	Beta-2 adrenergic receptor	ADRB2	0.0187
3274	Hydroxylamine reductase	hcp	0.0186
4804	Hydroxylamine reductase	hcp	0.0186
191	Peptide methionine sulfoxide reductase	MSRA	0.0186
591	Glutamate [NMDA] receptor subunit 3B	GRIN3B	0.0184
4811	Amylosucrase	ams	0.0183
2280	Listeriolysin regulatory protein	prfA	0.0182
864	Gag-Pol polyprotein	gag-pol	0.018
2237	Gag-Pol polyprotein	gag-pol	0.018
2326	Gag-Pol polyprotein	gag-pol	0.018
2451	Gag-Pol polyprotein	gag-pol	0.018
2901	Gag-Pol polyprotein	gag-pol	0.018
3165	Gag-Pol polyprotein	gag-pol	0.018
3722	Gag-Pol polyprotein	gag-pol	0.018
6306	Gag-Pol polyprotein	gag-pol	0.018
6624	Gag-Pol polyprotein	gag-pol	0.018
6144	Solute carrier family 22 member 2	SLC22A2	0.0178
378	Alpha-2C adrenergic receptor	ADRA2C	0.0176
4608	Putative cytochrome P450	SCO1207	0.0176
4963	Putative cytochrome P450	SCO2884	0.0176
6254	Putative cytochrome P450	SCO6998	0.0176
33	Cystine/glutamate transporter	SLC7A11	0.0175
422	Vitamin K-dependent protein C	PROC	0.0175
1245	Vitamin K-dependent protein S	PROS1	0.0175
629	Alpha-2B adrenergic receptor	ADRA2B	0.0173
3462	Tyrosine-protein kinase transforming protein Abl	ABL	0.0173
3399	Limonene-1,2-epoxide hydrolase	limA	0.0173
837	Glutamate [NMDA] receptor subunit epsilon-1	GRIN2A	0.0169
833	Organic cation/carnitine transporter 1	SLC22A4	0.0168
1181	Alpha-1-acid glycoprotein 1	ORM1	0.0167
831	D(2) dopamine receptor	DRD2	0.0167
4533	Glyoxalase family protein	BC_1747	0.0165
3500	Putative family 31 glucosidase yicI	yicI	0.0164
606	Cytochrome P450 27, mitochondrial	CYP27A1	0.0163
1750	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1	PFKFB1	0.0161
577	Argininosuccinate lyase	ASL	0.0161
917	Glutaminase kidney isoform, mitochondrial	GLS	0.0159
3984	Probable glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial	PET112L	0.0159
5	Glutaminase liver isoform, mitochondrial	GLS2	0.0159
355	GMP synthase [glutamine-hydrolyzing]	GMPS	0.0159
4353	GMP synthase [glutamine-hydrolyzing]	guaA	0.0159
3991	Glutamine-dependent NAD(+) synthetase	NADSYN1	0.0159
3982	Phosphoribosylformylglycinamidine synthase	PFAS	0.0159
5261	Phosphoribosylformylglycinamidine synthase	purL	0.0159
3480	Mannan endo-1,4-beta-mannosidase	manA	0.0157
1615	Chymase	CMA1	0.0156
1024	Solute carrier family 22 member 11	SLC22A11	0.0155
4992	Cytochrome c peroxidase	Not Available	0.0154
318	Alpha-2A adrenergic receptor	ADRA2A	0.0154
6149	Solute carrier family 22 member 10	SLC22A10	0.0154
382	Glutamate receptor, ionotropic kainate 1	GRIK1	0.0154
3895	Kynurenine--oxoglutarate transaminase 3	CCBL2	0.0153
665	Phosphoserine aminotransferase	PSAT1	0.0153
4652	Phosphoserine aminotransferase	serC	0.0153
801	Kynurenine/alpha-aminoadipate aminotransferase mitochondrial	AADAT	0.0153
420	Glutamate decarboxylase 1	GAD1	0.0153
3900	Glutamate decarboxylase 1	GAD1	0.0153
625	Glutamate carboxypeptidase 2	FOLH1	0.0152
6145	Solute carrier family 22 member 1	SLC22A1	0.0152
3583	6-phosphogluconolactonase	pgl	0.0152
798	Osteocalcin	BGLAP	0.0152
5126	Arginase	rocF	0.0151
4010	Mitochondrial dicarboxylate carrier	SLC25A10	0.0151
4008	Succinyl-CoA:3-ketoacid-coenzyme A transferase 2, mitochondrial	OXCT2	0.0151
1410	Oxidoreductase	HSD17B6	0.0151
4725	Oxidoreductase	Not Available	0.0151
5124	Oxidoreductase	Not Available	0.0151
4007	Succinate receptor 1	SUCNR1	0.0151
4002	Succinyl-CoA ligase [GDP-forming] subunit alpha, mitochondrial	SUCLG1	0.0151
25	Solute carrier family 13 member 1	SLC13A1	0.0151
673	Solute carrier family 13 member 3	SLC13A3	0.0151
391	Succinyl-CoA ligase [GDP-forming] beta-chain, mitochondrial	SUCLG2	0.0151
4009	Succinyl-CoA ligase [ADP-forming] beta-chain, mitochondrial	SUCLA2	0.0151
3823	Cytokine receptor common gamma chain	IL2RG	0.0151
498	Solute carrier family 13 member 2	SLC13A2	0.0151
287	Beta-1,4-galactosyltransferase 1	B4GALT1	0.015
871	Glucocorticoid receptor	NR3C1	0.0149
893	[Citrate [pro-3S]-lyase] ligase	citC	0.0149
845	Pyruvate dehydrogenase [cytochrome]	poxB	0.0149
4602	Osmotically inducible protein C	tthHB8IM	0.0149
2664	S-ribosylhomocysteine lyase	luxS	0.0149
2725	S-ribosylhomocysteine lyase	luxS	0.0149
2670	Pyridoxamine kinase	pdxY	0.0149
6161	Probable low affinity copper uptake protein 2	SLC31A2	0.0148
3939	Amine oxidase [flavin-containing] B	MAOB	0.0147
908	Glutathione S-transferase theta-1	GSTT1	0.0145
916	Metabotropic glutamate receptor 1	GRM1	0.0145
1671	Excitatory amino acid transporter 3	SLC1A1	0.0142
923	Glutamate receptor 3	GRIA3	0.0142
3877	Growth-inhibiting protein 18	GIG18	0.0141
5582	Regulator of transcription; stringent starvation protein A	sspA	0.0139
4695	UPF0124 protein yfiH	yfiH	0.0139
5598	Glycerol uptake operon antiterminator-related protein	TM_1436	0.0139
5577	N5-carboxyaminoimidazole ribonucleotide mutase	purE	0.0139
3792	KHG/KDPG aldolase [Includes: 4-hydroxy-2-oxoglutarate aldolase	eda	0.0139
5583	RNA 3'-terminal phosphate cyclase	rtcA	0.0139
2838	Ribose-5-phosphate isomerase A	rpiA	0.0139
2952	Ribose-5-phosphate isomerase A	rpiA	0.0139
5595	Ribose-5-phosphate isomerase A	rpiA	0.0139
5590	N utilization substance protein B homolog	nusB	0.0139
5060	Intron-associated endonuclease 1	ITEVIR	0.0139
5588	Cell division protein FtsY	TM_0570	0.0139
5587	Iron(III)-binding periplasmic protein	fbpA	0.0139
5575	Short tail fiber protein	12	0.0139
5592	Ribonucleoside-diphosphate reductase subunit beta	nrdF	0.0139
5591	Complement component C8 gamma chain	C8G	0.0139
5600	Pyruvate decarboxylase	pdc	0.0139
4238	50S ribosomal protein L4	rplD	0.0139
5578	50S ribosomal protein L4	rplD	0.0139
6173	50S ribosomal protein L4	rplD	0.0139
6219	50S ribosomal protein L4	rplD	0.0139
5581	Beta-fructosidase	bfrA	0.0139
4375	Glutamine synthetase 1	glnA1	0.0139
5593	Transferase	Not Available	0.0139
5574	Invasin	YPTB1668	0.0139
5586	Pleckstrin homology domain-containing family A member 1	PLEKHA1	0.0139
5580	Hexon protein	PII	0.0139
2314	Triosephosphate isomerase	TPI	0.0139
3417	Triosephosphate isomerase	tpiA	0.0139
3443	Triosephosphate isomerase	tpiA	0.0139
6346	Triosephosphate isomerase	TPI1	0.0139
2697	Uridine-cytidine kinase 2	UCK2	0.0139
369	Coagulation factor VII	F7	0.0139
811	Translocator protein	TSPO	0.0137
6163	Copper-transporting ATPase 2	ATP7B	0.0136
6165	Copper-transporting ATPase 1	ATP7A	0.0136
426	Aspartate aminotransferase, mitochondrial	GOT2	0.0135
763	Tyrosine aminotransferase	TAT	0.0131
5493	Tyrosine aminotransferase	Not Available	0.0131
724	Interleukin-2 receptor alpha chain	IL2RA	0.0131
717	Interleukin-2 receptor subunit beta	IL2RB	0.0131
1881	Hexokinase-1	HK1	0.0131
735	Alanine aminotransferase 1	GPT	0.0131
3904	Alanine aminotransferase 2	GPT2	0.0131
585	Aspartyl/asparaginyl beta-hydroxylase	ASPH	0.0131
3599	Peroxiredoxin-2	PRDX2	0.013
242	Asparagine synthetase [glutamine-hydrolyzing]	ASNS	0.013
2378	Carboxymethylenebutenolidase	clcD	0.013
787	Vitamin K epoxide reductase complex subunit 1	VKORC1	0.0129
2705	Dimethyl sulfoxide reductase	dmsA	0.0129
6146	High affinity copper uptake protein 1	SLC31A1	0.0129
505	Glutamate [NMDA] receptor subunit epsilon-3	GRIN2C	0.0129
1043	Trifunctional purine biosynthetic protein adenosine-3 [Includes: Phosphoribosylamine--glycine ligase	GART	0.0128
80	Peroxisome proliferator-activated receptor alpha	PPARA	0.0127
439	Glutamate [NMDA] receptor subunit epsilon-4	GRIN2D	0.0127
4031	Glutathione S-transferase A1	GSTA1	0.0126
6147	Solute carrier family 22 member 3	SLC22A3	0.0124
6031	Cytochrome P450 3A43	CYP3A43	0.0124
103	Muscarinic acetylcholine receptor M1	CHRM1	0.0124
3132	Tryptophan synthase alpha chain	trpA	0.0123
6568	Tryptophan synthase alpha chain	trpA	0.0123
795	Branched-chain-amino-acid aminotransferase, mitochondrial	BCAT2	0.0122
624	Guanidinoacetate N-methyltransferase	GAMT	0.0122
4003	Succinyl-CoA:3-ketoacid-coenzyme A transferase 1, mitochondrial	OXCT1	0.0122
469	Annexin A1	ANXA1	0.0122
5006	RNASE4 protein	RNASE4	0.0121
2555	Pol polyprotein	pol	0.0121
3242	Pol polyprotein	gag-pol	0.0121
3471	Pol polyprotein	gag-pro-pol	0.0121
5256	Pol polyprotein	pol	0.0121
6469	Pol polyprotein	gag-pol	0.0121
6565	Pol polyprotein	Not Available	0.0121
3940	Gamma-butyrobetaine dioxygenase	BBOX1	0.0121
3964	Trimethyllysine dioxygenase, mitochondrial	TMLHE	0.0121
97	Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1	PLOD1	0.012
3938	Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3	PLOD3	0.012
2521	Cell division protein ftsZ	ftsZ	0.012
3301	Cell division protein ftsZ	ftsZ	0.012
1467	Tumor necrosis factor ligand superfamily member 13B	TNFSF13B	0.012
2714	Chorismate mutase	aroH	0.012
4611	Chorismate mutase	aroG	0.012
574	Branched-chain-amino-acid aminotransferase, cytosolic	BCAT1	0.012
401	Glutamate [NMDA] receptor subunit zeta-1	GRIN1	0.0119
918	Glutamate receptor, ionotropic kainate 2	GRIK2	0.0119
5278	Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1	PAPSS1	0.0118
464	Glutamate [NMDA] receptor subunit epsilon-2	GRIN2B	0.0116
4373	Medium-chain-fatty-acid--CoA ligase	Not Available	0.0116
2236	Casein kinase II subunit alpha	CSNK2A1	0.0115
2149	Angiogenin	ANG	0.0113
4600	Malonamidase E2	Not Available	0.0113
899	Glutathione S-transferase Mu 3	GSTM3	0.0111
905	Glutathione transferase omega-1	GSTO1	0.0111
303	Diamine acetyltransferase 2	SAT2	0.0109
623	Spermine oxidase	SMOX	0.0109
1317	Spermine synthase	SMS	0.0109
921	Glutamate receptor 2	GRIA2	0.0109
4006	Succinate dehydrogenase cytochrome b560 subunit, mitochondrial	SDHC	0.0109
4001	Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial	SDHB	0.0108
1656	CYP2B protein	CYP2B	0.0108
2942	Sialidase	nanH	0.0107
3546	Sialidase	nedA	0.0107
2869	1-deoxy-D-xylulose 5-phosphate reductoisomerase	dxr	0.0107
4773	Deoxycytidine kinase	DCK	0.0106
1123	Eosinophil cationic protein	RNASE3	0.0106
239	Coagulation factor X	F10	0.0105
3116	Bacterioferritin	bfr	0.0105
4906	Bacterioferritin	bfr	0.0105
4965	Bacterioferritin	bfr	0.0105
3709	Glycerol uptake facilitator protein	glpF	0.0105
3393	TGF-beta receptor type-2	TGFBR2	0.0105
5489	Ribonucleoside-diphosphate reductase 1 subunit beta	nrdB	0.0105
3238	Multidrug resistance protein mexA	mexA	0.0105
3173	Enolase	eno	0.0105
3336	C4-dicarboxylate transport transcriptional regulatory protein dctD	dctD	0.0105
2805	Heparan sulfate glucosamine 3-O-sulfotransferase 3A1	HS3ST3A1	0.0104
941	Betaine--homocysteine S-methyltransferase 1	BHMT	0.0104
1768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit	GNG2	0.0103
1581	G protein-activated inward rectifier potassium channel 2	KCNJ6	0.0103
1571	G protein-activated inward rectifier potassium channel 1	KCNJ3	0.0103
1268	Neuropeptide S receptor	NPSR1	0.0103
332	Beta-lactamase	blaZ	0.0103
2478	Beta-lactamase	ampC	0.0103
2613	Beta-lactamase	ampC	0.0103
2635	Beta-lactamase	ampC	0.0103
2700	Beta-lactamase	penP	0.0103
5445	Beta-lactamase	blaB	0.0103
6019	Beta-lactamase	SHV-7	0.0103
6701	Beta-lactamase	cphA	0.0103
2452	Tryptophanyl-tRNA synthetase	trpS	0.0102
1284	Nuclear receptor subfamily 1 group I member 2	NR1I2	0.0102
5189	Trimethylamine dehydrogenase	tmd	0.0101
283	SEC14-like protein 2	SEC14L2	0.01
3175	Glutamate--cysteine ligase	gshA	0.01
708	Alpha-tocopherol transfer protein	TTPA	0.01
123	Diamine acetyltransferase 1	SAT1	0.01
4077	Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform	PPP2CB	0.0099
375	SEC14-like protein 3	SEC14L3	0.0099
86	SEC14-like protein 4	SEC14L4	0.0099
4076	Diacylglycerol kinase alpha	DGKA	0.0098
3221	Cytochrome c4	cc4	0.0098
411	Glycine N-methyltransferase	GNMT	0.0097
3478	Glucose-1-phosphate thymidylyltransferase	rmlA	0.0097
4277	Glucose-1-phosphate thymidylyltransferase	rmlA	0.0097
997	Protein kinase C beta type	PRKCB	0.0097
4078	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	PPP2CA	0.0097
197	Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial	SDHA	0.0095
2439	Alpha,alpha-trehalose-phosphate synthase [UDP-forming]	otsA	0.0095
5579	Carboxypeptidase B	CPB1	0.0092
2852	DNA mismatch repair protein mutL	mutL	0.0091
474	Acetylcholinesterase	ACHE	0.0091
6859	Protein S100-A4	S100A4	0.0091
2775	Dihydroorotate dehydrogenase	pyrD	0.009
2503	Phosphomannomutase/phosphoglucomutase	algC	0.009
3384	Macrophage migration inhibitory factor	MIF	0.009
128	Adenine phosphoribosyltransferase	APRT	0.009
2183	Fatty acid-binding protein, adipocyte	FABP4	0.0089
2101	Glutathione-requiring prostaglandin D synthase	HPGDS	0.0089
3830	Calreticulin	CALR	0.0088
385	Potassium-transporting ATPase alpha chain 1	ATP4A	0.0088
6034	Hydroxyindole O-methyltransferase	ASMT	0.0086
6035	Nuclear receptor ROR-beta	RORB	0.0086
2300	Lysozyme	E	0.0086
3633	Lysozyme	R	0.0086
5597	Lysozyme	17	0.0086
6036	Eosinophil peroxidase	EPX	0.0086
1970	Protein kinase C alpha type	PRKCA	0.0086
6459	Glycodelin	PAEP	0.0083
2206	Glucose-6-phosphate isomerase	GPI	0.0082
6495	Cytochrome c oxidase subunit 7C, mitochondrial	COX7C	0.0081
6499	Cytochrome c oxidase polypeptide 7A1, mitochondrial	COX7A1	0.0081
6496	Cytochrome c oxidase subunit 8A, mitochondrial	COX8A	0.0081
6494	Cytochrome c oxidase subunit 7B, mitochondrial	COX7B	0.0081
6493	Cytochrome c oxidase subunit 6C	COX6C	0.0081
6491	Cytochrome c oxidase subunit 5A, mitochondrial	COX5A	0.0081
6497	Cytochrome c oxidase subunit 6A2, mitochondrial	COX6A2	0.0081
6498	Cytochrome c oxidase subunit 6B1	COX6B1	0.0081
5793	Cytochrome c oxidase subunit 2	MT-CO2	0.0081
6559	Cytochrome c oxidase subunit 2	ctaC	0.0081
6669	Cytochrome c oxidase subunit 2	ctaC	0.0081
6489	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	COX4I1	0.0081
6490	Cytochrome c oxidase subunit 3	MT-CO3	0.0081
371	Cytochrome c oxidase subunit 1	MT-CO1	0.0081
6558	Cytochrome c oxidase subunit 1	ctaD	0.0081
551	Carnitine O-acetyltransferase	CRAT	0.0081
6073	Potassium channel subfamily K member 9	KCNK9	0.008
6072	Potassium channel subfamily K member 3	KCNK3	0.0079
449	Ornithine decarboxylase	ODC1	0.0078
4692	A/G-specific adenine glycosylase	mutY	0.0076
1630	Integrin beta-2	ITGB2	0.0076
5818	Folate receptor alpha	FOLR1	0.0076
204	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE5A	0.0075
765	Indoleamine 2,3-dioxygenase	IDO1	0.0074
571	Melatonin receptor type 1A	MTNR1A	0.0074
362	Melatonin receptor type 1B	MTNR1B	0.0074
2802	Endoglucanase G	celCCG	0.0073
734	D1 dopamine receptor-interacting protein calcyon	CALY	0.0072
6043	Putative G-protein coupled receptor 44	GPR44	0.007
1714	Mitogen-activated protein kinase 3	MAPK3	0.007
275	Arachidonate 5-lipoxygenase	ALOX5	0.0069
933	Proto-oncogene tyrosine-protein kinase Src	SRC	0.0066
293	Gamma-glutamyl hydrolase	GGH	0.0066
462	Intermediate conductance calcium-activated potassium channel protein 4	KCNN4	0.0065
3293	Flavodoxin	Not Available	0.0065
4614	Flavodoxin	DVU_2680	0.0065
5172	Flavodoxin	isiB	0.0065
5173	Flavodoxin	isiB	0.0065
5182	Flavodoxin	fldA	0.0065
5181	Hypothetical protein yhdA	azr	0.0065
5179	Probable aromatic acid decarboxylase	pad1	0.0065
5197	Trp repressor binding protein WrbA, putative	DR_A0214	0.0065
5200	NADH dehydrogenase	nox	0.0065
5201	FMN-binding protein	DvMF_2023	0.0065
5178	Protein nrdI	nrdI	0.0065
5198	Flavodoxin-1	fldA	0.0065
5170	Epidermin decarboxylase	epiD	0.0065
5175	Hypothetical protein SMU.260	SMU_260	0.0065
5202	Nitroreductase family protein	BC_1844	0.0065
5131	PhzG	phzG	0.0065
5193	Phenazine biosynthesis protein phzG	phzG	0.0065
5190	Rubredoxin-oxygen oxidoreductase	roo	0.0065
5191	Morphinone reductase	morB	0.0065
2586	Isopentenyl-diphosphate Delta-isomerase	idi	0.0065
5187	Isopentenyl-diphosphate delta-isomerase	fni	0.0065
5199	Isopentenyl-diphosphate delta-isomerase	fni	0.0065
2371	Pantothenate kinase	coaA	0.0065
4405	Nitric oxide reductase	fprA	0.0065
1561	Troponin C, slow skeletal and cardiac muscles	TNNC1	0.0064
636	Mitochondrial carnitine/acylcarnitine carrier protein	SLC25A20	0.0062
109	Mitochondrial carnitine/acylcarnitine carrier protein CACL	SLC25A29	0.0062
1502	Peroxisome proliferator-activated receptor delta	PPARD	0.0061
6270	Group IIE secretory phospholipase A2	PLA2G2E	0.006
6044	Serum paraoxonase/lactonase 3	PON3	0.0059
3027	Streptavidin	Not Available	0.0059
4836	Ferredoxin-dependent glutamate synthase 2	gltS	0.0058
2207	Rhodopsin	RHO	0.0056
572	Integrin alpha-L	ITGAL	0.0056
5304	UPF0166 protein TM_0021	TM_0021	0.0055
5288	Shikimate kinase	aroK	0.0055
5314	UPF0079 ATP-binding protein HI0065	HI_0065	0.0055
5293	Shikimate kinase 2	aroL	0.0055
5287	Signaling protein	Not Available	0.0055
5292	Putative partitioning protein	TT_C1605	0.0055
5266	Activator of	hgdC	0.0055
2874	Nitrogenase iron protein 1	nifH1	0.0055
5283	D-alanine--D-alanine ligase B	ddlB	0.0055
5281	Plasmid segregation protein parM	parM	0.0055
5276	Chromosomal replication initiator protein dnaA	dnaA	0.0055
5305	Phosphoribosylaminoimidazole carboxylase ATPase subunit	purK	0.0055
5299	D-alanine--D-alanine ligase	ddl	0.0055
6598	D-alanine--D-alanine ligase	ddl	0.0055
5259	Transcriptional regulator	ntrC1	0.0055
6699	Transcriptional regulator	Cgl2612	0.0055
4346	Polynucleotide kinase	pseT	0.0055
5290	ATP-dependent hsl protease ATP-binding subunit hslU	hslU	0.0055
5638	ATP-dependent hsl protease ATP-binding subunit hslU	hslU	0.0055
5270	ATP-dependent Clp protease ATP-binding subunit clpX	clpX	0.0055
5291	Glycogen synthase 1	glgA1	0.0055
5275	Multidrug resistance ABC transporter ATP-binding and permease protein	lmrA	0.0055
5264	DNA replication protein	REP	0.0055
4794	Phosphoenolpyruvate carboxykinase [ATP]	pckA	0.0055
5315	Chaperone protein htpG	htpG	0.0055
3777	ATP-dependent Clp protease ATP-binding subunit clpA	clpA	0.0055
1549	Heat shock 70 kDa protein 1	HSPA1A	0.0055
5308	Preprotein translocase secA 1 subunit	secA1	0.0055
5285	Kinesin heavy chain	KIF5B	0.0055
5284	Large T antigen	Not Available	0.0055
5277	Preprotein translocase subunit secA	secA	0.0055
5176	YtnJ	moxC	0.0055
3680	Dihydroorotate dehydrogenase A	pyrDA	0.0055
4407	FMN-dependent NADH-azoreductase	azoR	0.0054
5169	FMN-dependent NADH-azoreductase	azoR	0.0054
5206	Phosphopantothenoylcysteine decarboxylase	PPCDC	0.0054
3766	Pyridoxamine 5'-phosphate oxidase	pdxH	0.0054
3507	Chorismate synthase	aroC	0.0054
5171	Chorismate synthase	aroC	0.0054
451	Carnitine O-palmitoyltransferase I, liver isoform	CPT1A	0.0054
200	Carnitine O-palmitoyltransferase 2, mitochondrial	CPT2	0.0054
412	Peroxisomal carnitine O-octanoyltransferase	CROT	0.0054
6268	Hydroxyacid oxidase 1	HAO1	0.0053
6155	ATP-binding cassette transporter sub-family C member 11	ABCC11	0.0051
6589	Delta-hemolysin	hld	0.0051
4527	Putative hydrolase ycdX	ycdX	0.0051
6424	Light-harvesting protein B-800/820 beta chain	Not Available	0.0051
6586	Protein S100-G	S100G	0.0051
4546	Aminotransferase, putative	TM_1131	0.0051
4545	Molybdopterin-converting factor subunit 2	moaE	0.0051
6591	ATP synthase C chain	atpH	0.0051
4524	Mannose-6-phosphate isomerase	yvyI	0.0051
4547	Iron binding protein FbpA	fbpA	0.0051
4514	Citrate lyase beta subunit-like protein	citE	0.0051
4781	Citrate lyase beta subunit-like protein	DR_1240	0.0051
6587	Rubredoxin	rub	0.0051
4538	Hypothetical protein VC1899	VC_1899	0.0051
6423	Light-harvesting protein B-800/820 alpha chain	Not Available	0.0051
4529	Oxalate decarboxylase oxdC	oxdC	0.0051
4536	Transcriptional regulator, IclR family	TM_0065	0.0051
2501	Protein ygbM	ygbM	0.0051
4526	Oligopeptide ABC transporter, periplasmic oligopeptide-binding protein	TM_1223	0.0051
4535	Glutaconyl-CoA decarboxylase subunit alpha	gcdA	0.0051
4522	Arginine N-succinyltransferase subunit alpha	astA	0.0051
4548	Gyrase B	gyrB	0.0051
658	Para-aminobenzoate synthase component 1	pabB	0.0051
4515	Peripheral plasma membrane protein CASK	CASK	0.0051
6588	Methionyl-tRNA formyltransferase	fmt	0.005
6585	HLA class I histocompatibility antigen, B-27 alpha chain	HLA-B	0.005
4718	Putative ATP-dependent Clp protease proteolytic subunit, mitochondrial	CLPP	0.005
4122	Histone deacetylase 2	HDAC2	0.005
6593	Immunoglobulin G-binding protein G	spg	0.005
6592	Probable L-ascorbate-6-phosphate lactonase ulaG	ulaG	0.005
6206	DNA-directed RNA polymerase subunit beta'	rpoC	0.005
6608	Serine/threonine-protein kinase Sgk1	SGK1	0.005
6040	6-phosphogluconate dehydrogenase, decarboxylating	PGD	0.0047
685	Oxygen-insensitive NADPH nitroreductase	nfsA	0.0046
6945	Oxygen-insensitive NADPH nitroreductase	rdxA	0.0046
284	DNA-directed RNA polymerase beta chain	rpoB	0.0046
5773	DNA-directed RNA polymerase beta chain	rpoB	0.0046
6160	Solute carrier organic anion transporter family member 3A1	SLCO3A1	0.0046
6150	Solute carrier organic anion transporter family member 4C1	SLCO4C1	0.0045
2261	Major NAD(P)H-flavin oxidoreductase	Not Available	0.0045
3261	Signal recognition particle protein	ffh	0.0045
4517	Probable butyrate kinase 2	buk2	0.0045
6319	Respiratory nitrate reductase 1 gamma chain	narI	0.0044
3759	Glutathione S-transferase	gst	0.0044
4541	Glutathione S-transferase	GST	0.0044
4542	Glutaminase 1	glsA1	0.0044
4544	Glutaminase 1	glsA1	0.0044
3237	Beta-lactamase OXA-2	bla	0.0044
6279	Beta-2-microglobulin	B2M	0.0044
4528	Phenazine biosynthesis protein PhzD	phzD1	0.0044
6318	Respiratory nitrate reductase 1 beta chain	narH	0.0044
56	Delta-aminolevulinic acid dehydratase	ALAD	0.0044
2356	Delta-aminolevulinic acid dehydratase	hemB	0.0044
3613	Delta-aminolevulinic acid dehydratase	hemB	0.0044
3674	Delta-aminolevulinic acid dehydratase	hemB	0.0044
2929	(S)-2-haloacid dehalogenase	dhlB	0.0044
2995	(S)-2-haloacid dehalogenase	Not Available	0.0044
6317	Respiratory nitrate reductase 1 alpha chain	narG	0.0044
4532	Gephyrin	GPHN	0.0044
6128	Carbonic anhydrase-related protein 10	CA10	0.0044
6133	Sodium channel subunit beta-2	SCN2B	0.0044
6134	Sodium channel subunit beta-3	SCN3B	0.0044
6132	Sodium channel subunit beta-1	SCN1B	0.0044
6135	Sodium channel subunit beta-4	SCN4B	0.0044
6129	Carbonic anhydrase-related protein 11	CA11	0.0044
6127	Carbonic anhydrase-related protein	CA8	0.0044
4837	Cag-alfa	cag-alfa	0.0044
4839	DNA polymerase III subunit tau	dnaX	0.0044
4838	PMS1 protein homolog 2	PMS2	0.0044
3390	Aminoglycoside 3'-phosphotransferase	aphA	0.0044
6029	Aminoglycoside 3'-phosphotransferase	aphA1	0.0044
5302	TrwB	trwB	0.0044
5646	Galactokinase	GALK1	0.0044
5265	FtsH	ftsH	0.0044
4106	Guanylate kinase	GUK1	0.0044
4516	Guanylate kinase	gmk	0.0044
413	Amidophosphoribosyltransferase	PPAT	0.0044
2515	Amidophosphoribosyltransferase	purF	0.0044
3714	Amidophosphoribosyltransferase	purF	0.0044
6277	Heat shock cognate 71 kDa protein	HSPA8	0.0044
4774	NTPase P4	Not Available	0.0044
2270	Dephospho-CoA kinase	coaE	0.0044
3426	Glutamine synthetase	glnA	0.0044
3987	Glutamine synthetase	GLUL	0.0044
2284	Adenylate kinase	adk	0.0044
2296	Adenylate kinase	adk	0.0044
2311	Adenylate kinase	adk	0.0044
2312	Adenylate kinase	Not Available	0.0044
3470	Hypothetical protein MG245 homolog	MPN_348	0.0044
2751	Holliday junction ATP-dependent DNA helicase ruvB	ruvB	0.0043
4755	Holliday junction ATP-dependent DNA helicase ruvB	ruvB	0.0043
5295	2-keto-3-deoxy-gluconate kinase	TT_P0036	0.0043
203	Pyridoxine-5'-phosphate oxidase	PNPO	0.0043
2391	Ferrochelatase	hemH	0.0043
6502	Ferrochelatase	DKFZp686P18130	0.0043
1591	Ferrochelatase, mitochondrial	FECH	0.0043
340	Apoptotic protease-activating factor 1	APAF1	0.0043
4284	Pentaerythritol tetranitrate reductase	onr	0.0041
5300	Antigen peptide transporter 1	TAP1	0.0041
6158	Solute carrier organic anion transporter family member 1C1	SLCO1C1	0.0041
3467	Methylglyoxal synthase	mgsA	0.0041
6428	Light-harvesting protein B-800/850 beta chain	Not Available	0.0041
6427	Light-harvesting protein B-800/850 alpha chain	Not Available	0.0041
6533	Light-harvesting protein B-800/850 alpha chain	A1	0.0041
2132	Protein S100-B	S100B	0.004
309	Antithrombin-III	SERPINC1	0.004
4192	DNA topoisomerase 2-beta	TOP2B	0.0039
5312	Kinesin-like protein KIF1A	KIF1A	0.0039
2390	Nonsecretory ribonuclease	RNASE2	0.0039
2922	Glycerol kinase	glpK	0.0039
6220	Aryl hydrocarbon receptor	AHR	0.0039
5271	Focal adhesion kinase 1	PTK2	0.0039
2282	Protein recA	recA	0.0038
2315	Protein recA	recA	0.0038
2332	Protein recA	recA	0.0038
5263	Protein recA	recA	0.0038
6576	Geranylgeranyl transferase type-2 subunit beta	RABGGTB	0.0038
2525	3-phosphoshikimate 1-carboxyvinyltransferase	aroA	0.0038
3201	3-phosphoshikimate 1-carboxyvinyltransferase	aroA	0.0038
6575	Geranylgeranyl transferase type-2 subunit alpha	RABGGTA	0.0038
6124	Carbonic anhydrase 5B, mitochondrial	CA5B	0.0038
3803	Sodium channel protein type 3 subunit alpha	SCN3A	0.0038
6130	Carbonic anhydrase 13	CA13	0.0038
215	Sodium channel protein type 11 subunit alpha	SCN11A	0.0037
2688	Peptide deformylase	def	0.0037
2708	Peptide deformylase	def	0.0037
3004	Peptide deformylase	def	0.0037
4337	Peptide deformylase	def	0.0037
4338	Peptide deformylase	def	0.0037
5368	Peptide deformylase	def	0.0037
5371	Peptide deformylase	def	0.0037
6375	Peptide deformylase	def	0.0037
6378	Peptide deformylase	def	0.0037
6379	Peptide deformylase	def	0.0037
6776	Peptide deformylase	def	0.0037
6900	Peptide deformylase	def	0.0037
6131	Carbonic anhydrase 14	CA14	0.0037
4534	Cytohesin-2	CYTH2	0.0037
357	Carbonic anhydrase 2	CA2	0.0036
2615	Chemotaxis protein cheA	cheA	0.0036
2892	Acetylglutamate kinase	argB	0.0036
3550	Acetylglutamate kinase	argB	0.0036
2950	Inositol-trisphosphate 3-kinase A	ITPKA	0.0036
3669	Ribokinase	rbsK	0.0036
4564	YvbK protein	yvbK	0.0036
4567	Putative acyl-CoA thioester hydrolase HI0827	HI_0827	0.0036
4566	Acyl-CoA hydrolase	BC_2038	0.0036
4572	Acyl-CoA hydrolase	BH0798	0.0036
4576	Aac(6')-Ii protein	aac(6')-Ii	0.0036
6857	[Pyruvate dehydrogenase [lipoamide]] kinase isozyme 2, mitochondrial	PDK2	0.0036
4577	4'-phosphopantetheinyl transferase sfp	sfp	0.0036
2528	Fatty acid metabolism regulator protein	fadR	0.0036
6740	Fatty acid metabolism regulator protein	fadR	0.0036
4579	Serine acetyltransferase	cysE	0.0036
6807	Serine acetyltransferase	cysE	0.0036
825	Arsenical pump-driving ATPase	ASNA1	0.0036
3435	Arsenical pump-driving ATPase	arsA	0.0036
2548	Subtilisin Carlsberg	apr	0.0035
6832	Serine/threonine-protein kinase SRPK2	SRPK2	0.0035
788	Creatine kinase M-type	CKM	0.0035
137	FolC bifunctional protein [Includes: Folylpolyglutamate synthase	folC	0.0035
3802	Sodium channel protein type 2 subunit alpha	SCN2A	0.0035
3587	Gastrotropin	FABP6	0.0034
2540	Choloylglycine hydrolase	cbh	0.0034
6122	Carbonic anhydrase 3	CA3	0.0034
2727	S-adenosylmethionine synthetase	metK	0.0034
897	Glutathione S-transferase kappa 1	GSTK1	0.0034
1928	Leukotriene C4 synthase	LTC4S	0.0034
4043	Glutaredoxin-2, mitochondrial	GLRX2	0.0034
4035	Glutathione S-transferase Mu 5	GSTM5	0.0034
4037	Hypothetical protein	GPX1	0.0034
4297	Hypothetical protein	SP_1951	0.0034
4521	Hypothetical protein	BC_2969	0.0034
4540	Hypothetical protein	TM_1070	0.0034
4555	Hypothetical protein	MT1739	0.0034
4569	Hypothetical protein	mshD	0.0034
4578	Hypothetical protein	PA3270	0.0034
4747	Hypothetical protein	PA3967	0.0034
5177	Hypothetical protein	TM_0096	0.0034
5194	Hypothetical protein	PA1204	0.0034
5240	Hypothetical protein	Rv2991	0.0034
5370	Hypothetical protein	TM_1158	0.0034
5710	Hypothetical protein	Tb927.5.1360	0.0034
4029	Microsomal glutathione S-transferase 3	MGST3	0.0034
4032	Microsomal glutathione S-transferase 1	MGST1	0.0034
4030	Thioredoxin domain-containing protein 12	TXNDC12	0.0034
4040	Glutathione peroxidase 7	GPX7	0.0034
4034	Glutaredoxin-1	GLRX	0.0034
907	Glutathione peroxidase 2	GPX2	0.0034
906	Glutathione peroxidase 1	GPX1	0.0034
900	Glutathione S-transferase A4	GSTA4	0.0034
903	Glutathione S-transferase A5	GSTA5	0.0034
911	Glutathione peroxidase 3	GPX3	0.0034
4042	Glutathione transferase omega-2	GSTO2	0.0034
4036	Glutathione peroxidase 6	GPX6	0.0034
4033	S-formylglutathione hydrolase	ESD	0.0034
4038	Glutathione peroxidase 4	GPX4	0.0034
1975	Phospholipid hydroperoxide glutathione peroxidase, mitochondrial	GPX4	0.0034
4039	CDNA FLJ23636 fis, clone CAS07176	GPX8	0.0034
910	Epididymal secretory glutathione peroxidase	GPX5	0.0034
6390	Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	ATP2A1	0.0034
1056	Gamma-glutamyltranspeptidase 1	GGT1	0.0034
898	Glutathione S-transferase A3	GSTA3	0.0034
3319	Hydroxyacylglutathione hydrolase	HAGH	0.0034
6352	Reaction center protein H chain	puhA	0.0033
6456	Reaction center protein H chain	puhA	0.0033
6682	Reaction center protein H chain	puhA	0.0033
6353	Reaction center protein L chain	pufL	0.0033
6454	Reaction center protein L chain	pufL	0.0033
6683	Reaction center protein L chain	pufL	0.0033
6354	Reaction center protein M chain	pufM	0.0033
6455	Reaction center protein M chain	pufM	0.0033
6684	Reaction center protein M chain	pufM	0.0033
6351	Photosynthetic reaction center cytochrome c subunit	pufC	0.0033
453	S-adenosylmethionine synthetase isoform type-1	MAT1A	0.0033
6123	Carbonic anhydrase 5A, mitochondrial	CA5A	0.0033
2817	Phosphoribosylglycinamide formyltransferase 2	purT	0.0033
2334	Dethiobiotin synthetase	bioD	0.0033
6555	Dethiobiotin synthetase	bioD	0.0033
6501	Fatty acid-binding protein, liver	FABP1	0.0032
3804	Sodium channel protein type 4 subunit alpha	SCN4A	0.0032
1539	Oligopeptide transporter, small intestine isoform	SLC15A1	0.0032
48	Pyridoxal kinase	PDXK	0.0031
61	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase	folK	0.0031
2644	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase	folK	0.0031
2710	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase	folK	0.0031
424	Dihydroorotate dehydrogenase, mitochondrial	DHODH	0.0031
3489	Acetyl-coenzyme A synthetase	acs	0.0031
2396	Formyl-coenzyme A transferase	frc	0.0031
3457	Formyl-coenzyme A transferase	frc	0.0031
1995	Sodium channel protein type 9 subunit alpha	SCN9A	0.0031
3024	Crotonobetainyl-CoA:carnitine CoA-transferase	caiB	0.0031
2409	Acetyl-CoA acetyltransferase, cytosolic	ACAT2	0.0031
3007	Carbonic anhydrase 12	CA12	0.0031
4563	Acetyl transferase	rimL	0.0031
4565	Aminoglycoside 6'-N-acetyltransferase	aac(6')-Iy	0.0031
4205	Carbonic anhydrase 9	CA9	0.0031
3560	Gentamicin 3'-acetyltransferase	aacC1	0.0031
760	Fibroblast growth factor 1	FGF1	0.0031
702	UMP-CMP kinase	CMPK1	0.0031
2511	MAP kinase-activated protein kinase 2	MAPKAPK2	0.003
2184	Cystic fibrosis transmembrane conductance regulator	CFTR	0.003
2317	UDP-N-acetylmuramoylalanine--D-glutamate ligase	murD	0.003
2251	Thymidylate kinase	tmk	0.003
2254	Thymidylate kinase	DTYMK	0.003
3522	Thymidylate kinase	tmk	0.003
901	Glutathione S-transferase Mu 4	GSTM4	0.003
6126	Carbonic anhydrase 7	CA7	0.0029
6395	Myosin-14	MYH14	0.0029
15	Voltage-dependent T-type calcium channel subunit alpha-1I	CACNA1I	0.0029
952	Dipeptidyl peptidase 4	DPP4	0.0029
4573	Histone acetyltransferase PCAF	KAT2B	0.0029
2377	Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex	Not Available	0.0029
2560	Galactoside O-acetyltransferase	lacA	0.0029
3199	Phosphopantetheine adenylyltransferase	coaD	0.0029
3543	Phosphopantetheine adenylyltransferase	coaD	0.0029
3567	Phosphopantetheine adenylyltransferase	coaD	0.0029
5289	Phosphopantetheine adenylyltransferase	coaD	0.0029
2285	Streptogramin A acetyltransferase	vatD	0.0028
1422	Serine/threonine-protein kinase 6	AURKA	0.0028
4041	Microsomal glutathione S-transferase 2	MGST2	0.0028
4095	Neuronal acetylcholine receptor subunit alpha-7	CHRNA7	0.0028
947	Neuronal acetylcholine receptor subunit alpha-4	CHRNA4	0.0028
158	Sodium channel protein type 1 subunit alpha	SCN1A	0.0028
3379	Kinesin-like protein KIF11	KIF11	0.0028
504	Mast/stem cell growth factor receptor	KIT	0.0027
535	Voltage-dependent T-type calcium channel subunit alpha-1G	CACNA1G	0.0027
4404	FcbC1 protein	fcbC	0.0027
1313	Lactoylglutathione lyase	GLO1	0.0027
3822	Actin, alpha skeletal muscle	ACTA1	0.0027
964	Voltage-dependent T-type calcium channel subunit alpha-1H	CACNA1H	0.0026
3809	Estrogen-related receptor gamma	ESRRG	0.0026
6500	Phospholipase A2	PLA2G1B	0.0026
509	Thymidine kinase	TK	0.0026
570	Thymidine kinase	TK	0.0026
2559	Thymidine kinase	TK	0.0026
3430	Thymidine kinase	tdk	0.0026
3518	Thymidine kinase	TK	0.0026
5301	Thymidine kinase	tdk	0.0026
5771	Thymidine kinase	ORF36	0.0026
7009	Thymidine kinase	ORF36	0.0026
5294	Nucleoside diphosphate kinase A	NME1	0.0026
2376	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase	dapD	0.0026
841	Gamma-aminobutyric-acid receptor subunit alpha-6	GABRA6	0.0025
530	Gamma-aminobutyric-acid receptor subunit alpha-4	GABRA4	0.0025
1721	Glycogen synthase kinase-3 beta	GSK3B	0.0025
615	3-oxoacyl-[acyl-carrier-protein] synthase 3	fabH	0.0024
3138	3-oxoacyl-[acyl-carrier-protein] synthase 3	fabH	0.0024
4568	3-oxoacyl-[acyl-carrier-protein] synthase 3	fabH	0.0024
6370	3-oxoacyl-[acyl-carrier-protein] synthase 3	fabH	0.0024
523	Gamma-aminobutyric-acid receptor subunit alpha-5	GABRA5	0.0024
580	Gamma-aminobutyric-acid receptor subunit alpha-3	GABRA3	0.0024
423	Gamma-aminobutyric-acid receptor subunit alpha-2	GABRA2	0.0024
4388	Aminoglycoside 2'-N-acetyltransferase	aac	0.0024
592	Carbonic anhydrase 4	CA4	0.0024
4910	Cytoglobin	CYGB	0.0024
4947	Bacterial hemoglobin	vhb	0.0024
4984	Neuroglobin	NGB	0.0024
4943	Cytochrome c6	petJ	0.0024
4954	Soluble cytochrome b558	Not Available	0.0024
4925	Cytochrome c-type protein SHP	shp	0.0024
4934	Cytochrome c-551	nirM	0.0024
5218	Cytochrome c-551	nirM	0.0024
4961	Hemophore HasA	hasA	0.0023
4905	Cytochrome c2	Not Available	0.0023
4939	Cytochrome c2	cycA	0.0023
4964	Cytochrome c2	cycA	0.0023
4979	Cytochrome c2	cycA	0.0023
6673	Cytochrome c2	cycA	0.0023
4907	Cytochrome c-L	moxG	0.0023
6865	Cytochrome c-L	moxG	0.0023
4981	Iron-starvation protein PigA	pigA	0.0023
4936	Cytochrome c2 iso-2	Not Available	0.0023
4916	Cyanoglobin	glbN	0.0023
4994	Hemoglobin-like protein HbO	glbO	0.0023
4915	Cytochrome c-550	psbV	0.0023
4959	Cytochrome c-550	psbV	0.0023
5216	Cytochrome c-550	psbV	0.0023
4998	Hemoglobin-like protein yjbI	yjbI	0.0023
4935	Cytochrome c-554	cycA1	0.0023
4972	P450cin	cinA	0.0023
4764	Cytochrome P450 165C4	CYP165C4	0.0023
4975	Cytochrome c-556	RPA3973	0.0023
4942	Diheme cytochrome c napB	napB	0.0023
4971	Nonaheme cytochrome c	hmcA	0.0023
4989	Cytochrome c551 peroxidase	ccp	0.0023
5222	Cytochrome c551 peroxidase	ccpA	0.0023
4976	Apocytochrome f	petA	0.0023
6407	Apocytochrome f	petA	0.0023
4904	Cytochrome c family protein	GSU1996	0.0023
4903	Methyl-accepting chemotaxis protein	Tar4	0.0023
4909	CooA protein	cooA	0.0023
4960	Putative cytochrome P450-family protein	SCO7417	0.0023
5000	HemO	hemO	0.0023
4931	Cytochrome P450 167A1	CYP167A1	0.0023
4926	Heme-based aerotactic transducer hemAT	hemAT	0.0023
4922	Cytochrome c, putative	SO_4144	0.0023
4970	Cytochrome c nitrite reductase catalytic subunit	nrfA	0.0023
4908	Heme-regulated cyclic AMP phosphodiesterase	dosP	0.0023
4937	Cytochrome oxidase subunit II	rcoxA	0.0023
4993	Hydroxylamine oxidoreductase	hao1	0.0023
4999	Cytochrome P450 165B3	CYP165B3	0.0023
3093	Catalase HPII	katE	0.0023
4952	Catalase/peroxidase	katA	0.0023
295	Carbonic anhydrase 1	CA1	0.0022
220	Sodium channel protein type 5 subunit alpha	SCN5A	0.0021
1939	Heat shock protein HSP 90-alpha	HSP90AA1	0.0021
4813	Heme oxygenase	hmuO	0.002
5769	Heme oxygenase	Not Available	0.002
4990	PpcA	ppcA	0.002
4948	Cytochrome c-553	Not Available	0.002
4923	Cytochrome c3	DvMF_2499	0.002
4945	Cytochrome c3	Not Available	0.002
4949	Cytochrome c3	DVU_3171	0.002
4968	Cytochrome c3	cytc3	0.002
4997	Cytochrome c3	SO_2727	0.002
5219	Cytochrome c3	cyd	0.002
4988	Sulfite oxidase, mitochondrial	SUOX	0.002
3375	Acidic cytochrome c3	Not Available	0.002
4385	Cytochrome c'	Not Available	0.002
4967	Cytochrome c'	cycA	0.002
5038	Cytochrome c'	Not Available	0.002
5223	Cytochrome c'	cycP	0.002
2119	Cytochrome b5	CYB5A	0.002
4920	Peroxidase/catalase	katG	0.002
3570	Cytochrome P450 152A1	cypC	0.002
4902	Nine-heme cytochrome c	Ddes_2038	0.002
3189	High-molecular-weight cytochrome c	hmcA	0.002
2915	Sensor protein fixL	fixL	0.002
4944	Sensor protein fixL	fixL	0.002
4956	Quinohemoprotein alcohol dehydrogenase ADH IIB	qbdA	0.002
4289	Cytochrome P450	TT_P0059	0.002
6262	Cytochrome P450	staP	0.002
3670	Soluble cytochrome b562 precursor	cybC	0.0018
3291	Cytochrome c-552	cycA	0.0018
4927	Cytochrome c-552	nrfA	0.0018
4938	Cytochrome c-552	cycA	0.0018
4953	Cytochrome c-552	nrfA	0.0018
5217	Cytochrome c-552	cycM	0.0018
4386	Hemoglobin-like protein HbN	glbN	0.0018
2617	Nitric oxide synthase oxygenase	nos	0.0018
2701	Nitric oxide synthase oxygenase	nos	0.0018
2845	Bifunctional P-450:NADPH-P450 reductase	CYP102A1	0.0017
3127	Nitrite reductase	nirS	0.0017
3284	Nitrite reductase	nirS	0.0017
260	Cytochrome P450 51	ERG11	0.0015
761	Cytochrome P450 51	ERG11	0.0015
3163	Cytochrome P450 51	cyp51	0.0015
518	Peroxidase/catalase T	katG	0.0014
1507	Cytochrome c	CYCS	0.0014
693	Hemoglobin subunit beta	HBB	0.0014
2298	Cytochrome P450-cam	camC	0.0012

(*) Categorization taken from DrugBank: therapeutic category or general category of a drug (i.e. anti-convulsant, antibacterial, etc.)

DB00157 - NADH

Targets

Enzymes

Predictions