DT-Web

DB00407 - Ardeparin


Identification
Name Ardeparin
Accession Number DB00407 (APRD00803)
Type small molecule
Description Ardeparin, marketed under the US trade name Normiflo, is a low molecular weight heparin (LMWH) anticoagulant used for the prevention of postoperative venous thrombosis. Ardeparin is derived via peroxide degradation of heparin extracted from porcine intestinal mucosa. Its molecular weight ranges from 2000 to 15,000 with an average molecular weight of 5500 to 6500. Normiflo was withdrawn from the US market in March 2000.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 1134.928
Groups approved
Monoisotopic Weight 1134.006993818
Pharmacology
Indication For prevention of deep vein thrombosis, which may result in pulmonary embolism, following knee surgery.
Mechanism of action Ardeparin binds to antithrombin III, accelerating its activity in inactivating factor Xa and thrombin, thereby inhibiting thrombosis. Ardeparin also binds to heparin cofactor II, inhibiting thrombin. Ardeparin does not effect prothrombin time (PT) assays and may prolong activated partial thromboplastin time (APTT). Ardeparin has double the anti-factor Xa activity versus anti-factor IIa activity, compared to unfractionated heparin which has approximately equal anti-factor Xa activity and anti-factor IIa activity.
Absorption Well absorbed following subcutaneous administration, with a mean bioavailability of 92% (based on anti-factor Xa activity).
Protein binding Not Available
Biotransformation Liver and the reticulo-endothelial system are the sites of biotransformation.
Route of elimination Not Available
Toxicity Symptoms of overdose may include excessive bleeding and bruising.
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Antithrombin-III
Name Antithrombin-III
Gene Name SERPINC1
Pharmacological action yes
Actions potentiator
References
  • Mousa SA: The low molecular weight heparin, tinzaparin, in thrombosis and beyond. Cardiovasc Drug Rev. 2002 Fall;20(3):199-216. - Pubmed
  • Lin P, Sinha U, Betz A: Antithrombin binding of low molecular weight heparins and inhibition of factor Xa. Biochim Biophys Acta. 2001 Apr 3;1526(1):105-13. - Pubmed
  • Shaughnessy SG, Young E, Deschamps P, Hirsh J: The effects of low molecular weight and standard heparin on calcium loss from fetal rat calvaria. Blood. 1995 Aug 15;86(4):1368-73. - Pubmed
DTHybrid score 1.0185
Heparin cofactor 2
Name Heparin cofactor 2
Gene Name SERPIND1
Pharmacological action yes
Actions agonist
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Mousa SA: The low molecular weight heparin, tinzaparin, in thrombosis and beyond. Cardiovasc Drug Rev. 2002 Fall;20(3):199-216. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score 0.8922

Predictions


Id Partner name Gene Name Score
2058 P-selectin SELP 0.1514
239 Coagulation factor X F10 0.1206
1719 Heparanase HPSE 0.1019
2020 Stromal cell-derived factor 1 CXCL12 0.0902
1953 Proto-oncogene protein c-fos FOS 0.09
647 Integrin alpha-4 ITGA4 0.0783
1334 Tissue factor pathway inhibitor TFPI 0.047
1757 Myeloperoxidase MPO 0.0403
183 Vascular endothelial growth factor A VEGFA 0.0304
4878 Glycoprotein hormones alpha chain CGA 0.0148
1072 Granzyme B GZMB 0.0148
4856 CD209 antigen CD209 0.0148
4877 Beta-mannanase man 0.0148
1052 Cytotoxic T-lymphocyte protein 4 CTLA4 0.0148
4852 Reticulon-4 receptor RTN4R 0.0148
4850 Beta-2-glycoprotein 1 APOH 0.0148
757 Fusion glycoprotein F0 F 0.0148
4875 Fusion glycoprotein F0 F 0.0148
4869 Major capsid protein A430L 0.0148
4189 Alpha-galactosidase A GLA 0.0148
1354 Beta-glucuronidase GUSB 0.0148
4871 Endo-beta-N-acetylglucosaminidase F3 endOF3 0.0148
4880 Membrane cofactor protein CD46 0.0148
442 Envelope glycoprotein gp41 0.0148
4859 Envelope glycoprotein env 0.0148
1563 Platelet glycoprotein Ib alpha chain GP1BA 0.0148
4889 Ig epsilon chain C region IGHE 0.0148
4845 ADAM 33 ADAM33 0.0148
4882 Dipeptidyl aminopeptidase-like protein 6 DPP6 0.0148
4721 Beta-1,4-mannanase manA 0.0148
3352 Structural polyprotein Not Available 0.0148
3628 Structural polyprotein Not Available 0.0148
4892 Structural polyprotein Not Available 0.0148
793 T-cell surface antigen CD2 CD2 0.0129
119 Carcinoembryonic antigen-related cell adhesion molecule 1 CEACAM1 0.0129
4861 Interleukin-6 receptor alpha chain IL6R 0.0129
4193 Atrial natriuretic peptide clearance receptor NPR3 0.0129
3837 Cytokine receptor common beta chain CSF2RB 0.0129
1184 Interferon beta IFNB1 0.0121
4857 Zinc-alpha-2-glycoprotein AZGP1 0.0121
1379 Interleukin-12 subunit beta IL12B 0.012
6858 Inactive carboxylesterase 4 CES1P1 0.012
4890 Hemagglutinin HA 0.012
6566 Hemagglutinin Not Available 0.012
554 Low-density lipoprotein receptor LDLR 0.0119
2998 Sialic acid-binding Ig-like lectin 7 SIGLEC7 0.0114
6120 Cation-independent mannose-6-phosphate receptor IGF2R 0.0114
2297 Genome polyprotein Not Available 0.0114
2322 Genome polyprotein Not Available 0.0114
2694 Genome polyprotein Not Available 0.0114
2719 Genome polyprotein Not Available 0.0114
2860 Genome polyprotein Not Available 0.0114
2928 Genome polyprotein Not Available 0.0114
3160 Genome polyprotein Not Available 0.0114
3260 Genome polyprotein Not Available 0.0114
4783 Genome polyprotein Not Available 0.0114
5726 Genome polyprotein Not Available 0.0114
5779 Genome polyprotein Not Available 0.0114
5867 Genome polyprotein Not Available 0.0114
6253 Genome polyprotein Not Available 0.0114
6301 Genome polyprotein Not Available 0.0114
6380 Genome polyprotein Not Available 0.0114
6381 Genome polyprotein Not Available 0.0114
6437 Genome polyprotein Not Available 0.0114
6520 Genome polyprotein Not Available 0.0114
6521 Genome polyprotein Not Available 0.0114
6652 Genome polyprotein Not Available 0.0114
6734 Genome polyprotein Not Available 0.0114
6735 Genome polyprotein Not Available 0.0114
6736 Genome polyprotein Not Available 0.0114
6737 Genome polyprotein Not Available 0.0114
6738 Genome polyprotein Not Available 0.0114
6739 Genome polyprotein Not Available 0.0114
6744 Genome polyprotein Not Available 0.0114
6748 Genome polyprotein Not Available 0.0114
6894 Genome polyprotein Not Available 0.0114
6898 Genome polyprotein Not Available 0.0114
18 High affinity immunoglobulin epsilon receptor subunit alpha FCER1A 0.0113
3444 Cyanovirin-N Not Available 0.0109
3140 Hemagglutinin-neuraminidase HN 0.0109
3609 Hemagglutinin-neuraminidase HN 0.0109
3258 Mannosyl-oligosaccharide alpha-1,2-mannosidase MSDC 0.0108
1859 Prostatic acid phosphatase ACPP 0.0108
4787 Envelope glycoprotein gp160 env 0.0105
4820 Envelope glycoprotein gp160 env 0.0105
5727 Envelope glycoprotein gp160 env 0.0105
4666 Fucose-binding lectin PA-IIL lecB 0.0102
2372 Bifunctional tail protein 9 0.0101
595 Fibrinogen alpha chain FGA 0.0101
2577 Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase MAN1B1 0.0096
3480 Mannan endo-1,4-beta-mannosidase manA 0.0094
64 Neuraminidase NA 0.0091
641 Neuraminidase NA 0.0091
2676 Neuraminidase NA 0.0091
3026 Neuraminidase NA 0.0091
3519 Neuraminidase NA 0.0091
6007 Neuraminidase NA 0.0091
958 Insulin-like growth factor 1 receptor IGF1R 0.0091
1243 Cathepsin D CTSD 0.0089
1439 Lactotransferrin LTF 0.0088
1782 Neutrophil gelatinase-associated lipocalin LCN2 0.0088
2430 Chondroitinase B cslB 0.0085
2581 Chondroitinase AC cslA 0.0083
6847 Lactase-phlorizin hydrolase LCT 0.0082
3814 Complement C1r subcomponent C1R 0.0082
6307 Ig gamma-2 chain C region IGHG2 0.0082
6500 Phospholipase A2 PLA2G1B 0.0079
2207 Rhodopsin RHO 0.0077
4785 Ig gamma-1 chain C region IGHG1 0.0068
76 Nitric-oxide synthase, brain NOS1 0.0067
4604 Liver carboxylesterase 1 CES1 0.0067
952 Dipeptidyl peptidase 4 DPP4 0.0058
6589 Delta-hemolysin hld 0.0056
6424 Light-harvesting protein B-800/820 beta chain Not Available 0.0056
6591 ATP synthase C chain atpH 0.0056
6587 Rubredoxin rub 0.0056
6423 Light-harvesting protein B-800/820 alpha chain Not Available 0.0056
6586 Protein S100-G S100G 0.0056
6588 Methionyl-tRNA formyltransferase fmt 0.0056
4718 Putative ATP-dependent Clp protease proteolytic subunit, mitochondrial CLPP 0.0056
6592 Probable L-ascorbate-6-phosphate lactonase ulaG ulaG 0.0056
6585 HLA class I histocompatibility antigen, B-27 alpha chain HLA-B 0.0056
6593 Immunoglobulin G-binding protein G spg 0.0056
3923 Cholinesterase BCHE 0.0055
3175 Glutamate--cysteine ligase gshA 0.0053
20 Prostaglandin G/H synthase 1 PTGS1 0.005
6495 Cytochrome c oxidase subunit 7C, mitochondrial COX7C 0.0049
6493 Cytochrome c oxidase subunit 6C COX6C 0.0048
6498 Cytochrome c oxidase subunit 6B1 COX6B1 0.0048
6279 Beta-2-microglobulin B2M 0.0048
6497 Cytochrome c oxidase subunit 6A2, mitochondrial COX6A2 0.0048
6496 Cytochrome c oxidase subunit 8A, mitochondrial COX8A 0.0048
6499 Cytochrome c oxidase polypeptide 7A1, mitochondrial COX7A1 0.0048
6494 Cytochrome c oxidase subunit 7B, mitochondrial COX7B 0.0048
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.0048
6559 Cytochrome c oxidase subunit 2 ctaC 0.0048
6669 Cytochrome c oxidase subunit 2 ctaC 0.0048
6490 Cytochrome c oxidase subunit 3 MT-CO3 0.0048
6491 Cytochrome c oxidase subunit 5A, mitochondrial COX5A 0.0048
6489 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial COX4I1 0.0048
371 Cytochrome c oxidase subunit 1 MT-CO1 0.0048
6558 Cytochrome c oxidase subunit 1 ctaD 0.0048
6319 Respiratory nitrate reductase 1 gamma chain narI 0.0048
6318 Respiratory nitrate reductase 1 beta chain narH 0.0048
6317 Respiratory nitrate reductase 1 alpha chain narG 0.0048
6428 Light-harvesting protein B-800/850 beta chain Not Available 0.0045
6427 Light-harvesting protein B-800/850 alpha chain Not Available 0.0045
6533 Light-harvesting protein B-800/850 alpha chain A1 0.0045
6576 Geranylgeranyl transferase type-2 subunit beta RABGGTB 0.0042
6575 Geranylgeranyl transferase type-2 subunit alpha RABGGTA 0.0042
2132 Protein S100-B S100B 0.0041
6352 Reaction center protein H chain puhA 0.0036
6456 Reaction center protein H chain puhA 0.0036
6682 Reaction center protein H chain puhA 0.0036
6353 Reaction center protein L chain pufL 0.0036
6454 Reaction center protein L chain pufL 0.0036
6683 Reaction center protein L chain pufL 0.0036
6351 Photosynthetic reaction center cytochrome c subunit pufC 0.0036
6354 Reaction center protein M chain pufM 0.0036
6455 Reaction center protein M chain pufM 0.0036
6684 Reaction center protein M chain pufM 0.0036
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0035
3027 Streptavidin Not Available 0.0032
5682 Ribonuclease pancreatic RNASE1 0.0029
↑