DT-Web

DB07227 - 4-[(5-{[4-(3-CHLOROPHENYL)-3-OXOPIPERAZIN-1-YL]METHYL}-1H-IMIDAZOL-1-YL)METHYL]BENZONITRILE


Identification
Name 4-[(5-{[4-(3-CHLOROPHENYL)-3-OXOPIPERAZIN-1-YL]METHYL}-1H-IMIDAZOL-1-YL)METHYL]BENZONITRILE
Accession Number DB07227
Type small molecule
Description Not Available
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 405.88
Groups experimental
Monoisotopic Weight 405.135637994
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Protein farnesyltransferase/geranylgeranyltransferase type I alpha subunit
Name Protein farnesyltransferase/geranylgeranyltransferase type I alpha subunit
Gene Name FNTA
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 1.7435
Protein farnesyltransferase subunit beta
Name Protein farnesyltransferase subunit beta
Gene Name FNTB
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 1.4691
Geranylgeranyl transferase type-1 subunit beta
Name Geranylgeranyl transferase type-1 subunit beta
Gene Name PGGT1B
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 0.9501

Predictions


Id Partner name Gene Name Score
6574 GTPase KRas KRAS 0.2236
6576 Geranylgeranyl transferase type-2 subunit beta RABGGTB 0.2126
6575 Geranylgeranyl transferase type-2 subunit alpha RABGGTA 0.2124
6058 Geranylgeranyl pyrophosphate synthetase GGPS1 0.1312
853 Farnesyl pyrophosphate synthetase FDPS 0.1139
6571 Guanine nucleotide-binding protein G(T) subunit gamma-T1 GNGT1 0.0579
6573 Phosducin PDC 0.0578
6572 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 GNB1 0.0578
6577 Rab proteins geranylgeranyltransferase component A 1 CHM 0.0578
6595 Lantibiotic nisin-Z nisZ 0.0474
2383 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase ispF 0.0473
2937 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase ispF 0.0473
4620 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase ispF 0.0473
6594 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase ispF 0.0473
6609 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase ispF 0.0473
6646 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase ispF 0.0473
6596 Short-chain Z-isoprenyl diphosphate synthetase Rv1086 0.0412
5744 Undecaprenyl pyrophosphate synthetase uppS 0.032
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