DT-Web

DB00155 - L-Citrulline


Identification
Name L-Citrulline
Accession Number DB00155 (NUTR00021)
Type small molecule
Description Citrulline is an amino acid. It is made from ornithine and carbamoyl phosphate in one of the central reactions in the urea cycle. It is also produced from arginine as a by-product of the reaction catalyzed by NOS family. Its name is derived from citrullus, the Latin word for watermelon, from which it was first isolated.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 175.1857
Groups approved
Monoisotopic Weight 175.095691297
Pharmacology
Indication Used for nutritional supplementation, also for treating dietary shortage or imbalance.
Mechanism of action L-citrulline is converted to L-arginine by argininosuccinate synthase. L-arginine is in turn responsible for citrulline's therapeutic affects. Many of L-arginine's activities, including its possible anti-atherogenic actions, may be accounted for by its role as the precursor to nitric oxide or NO. NO is produced by all tissues of the body and plays very important roles in the cardiovascular system, immune system and nervous system. NO is formed from L-arginine via the enzyme nitric oxide synthase or synthetase (NOS), and the effects of NO are mainly mediated by 3',5' -cyclic guanylate or cyclic GMP. NO activates the enzyme guanylate cyclase, which catalyzes the synthesis of cyclic GMP from guanosine triphosphate or GTP. Cyclic GMP is converted to guanylic acid via the enzyme cyclic GMP phosphodiesterase.

NOS is a heme-containing enzyme with some sequences similar to cytochrome P-450 reductase. Several isoforms of NOS exist, two of which are constitutive and one of which is inducible by immunological stimuli. The constitutive NOS found in the vascular endothelium is designated eNOS and that present in the brain, spinal cord and peripheral nervous system is designated nNOS. The form of NOS induced by immunological or inflammatory stimuli is known as iNOS. iNOS may be expressed constitutively in select tissues such as lung epithelium.

All the nitric oxide synthases use NADPH (reduced nicotinamide adenine dinucleotide phosphate) and oxygen (O2) as cosubstrates, as well as the cofactors FAD (flavin adenine dinucleotide), FMN (flavin mononucleotide), tetrahydrobiopterin and heme. Interestingly, ascorbic acid appears to enhance NOS activity by increasing intracellular tetrahydrobiopterin. eNOS and nNOS synthesize NO in response to an increased concentration of calcium ions or in some cases in response to calcium-independent stimuli, such as shear stress. In vitro studies of NOS indicate that the Km of the enzyme for L-arginine is in the micromolar range. The concentration of L-arginine in endothelial cells, as well as in other cells, and in plasma is in the millimolar range. What this means is that, under physiological conditions, NOS is saturated with its L-arginine substrate. In other words, L-arginine would not be expected to be rate-limiting for the enzyme, and it would not appear that supraphysiological levels of L-arginine which could occur with oral supplementation of the amino acid would make any difference with regard to NO production. The reaction would appear to have reached its maximum level. However, in vivo studies have demonstrated that, under certain conditions, e.g. hypercholesterolemia, L-arginine could enhance endothelial-dependent vasodilation and NO production.
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Argininosuccinate synthase
Name Argininosuccinate synthase
Gene Name ASS1
Pharmacological action unknown
Actions Not Available
References
  • Braissant O, Honegger P, Loup M, Iwase K, Takiguchi M, Bachmann C: Hyperammonemia: regulation of argininosuccinate synthetase and argininosuccinate lyase genes in aggregating cell cultures of fetal rat brain. Neurosci Lett. 1999 May 7;266(2):89-92. - Pubmed
  • Braissant O, Gotoh T, Loup M, Mori M, Bachmann C: L-arginine uptake, the citrulline-NO cycle and arginase II in the rat brain: an in situ hybridization study. Brain Res Mol Brain Res. 1999 Jul 5;70(2):231-41. - Pubmed
  • Keilhoff G, Reiser M, Stanarius A, Aoki E, Wolf G: Citrulline immunohistochemistry for demonstration of NOS activity in vivo and in vitro. Nitric Oxide. 2000 Aug;4(4):343-53. - Pubmed
  • Zhang B, Cao GL, Domachowske J, Jackson MJ, Porasuphatana S, Rosen GM: Stable expression of varied levels of inducible nitric oxide synthase in primary cultures of endothelial cells. Anal Biochem. 2000 Nov 15;286(2):198-205. - Pubmed
  • Zhang WY, Gotoh T, Oyadomari S, Mori M: Coinduction of inducible nitric oxide synthase and arginine recycling enzymes in cytokine-stimulated PC12 cells and high output production of nitric oxide. Brain Res Mol Brain Res. 2000 Nov 10;83(1-2):1-8. - Pubmed
DTHybrid score 0.7247
NG,NG-dimethylarginine dimethylaminohydrolase 2
Name NG,NG-dimethylarginine dimethylaminohydrolase 2
Gene Name DDAH2
Pharmacological action unknown
Actions Not Available
References
  • Tran CT, Fox MF, Vallance P, Leiper JM: Chromosomal localization, gene structure, and expression pattern of DDAH1: comparison with DDAH2 and implications for evolutionary origins. Genomics. 2000 Aug 15;68(1):101-5. - Pubmed
  • Tain YL, Baylis C: Determination of dimethylarginine dimethylaminohydrolase activity in the kidney. Kidney Int. 2007 Oct;72(7):886-9. Epub 2007 Jul 25. - Pubmed
DTHybrid score 1.0207
Argininosuccinate synthase
Name Argininosuccinate synthase
Gene Name ASS1
Pharmacological action unknown
Actions Not Available
References
  • Husson A, Brasse-Lagnel C, Fairand A, Renouf S, Lavoinne A: Argininosuccinate synthetase from the urea cycle to the citrulline-NO cycle. Eur J Biochem. 2003 May;270(9):1887-99. - Pubmed
  • Hammermann R, Bliesener N, Mossner J, Klasen S, Wiesinger H, Wessler I, Racke K: Inability of rat alveolar macrophages to recycle L-citrulline to L-arginine despite induction of argininosuccinate synthetase mRNA and protein, and inhibition of nitric oxide synthesis by exogenous L-citrulline. Naunyn Schmiedebergs Arch Pharmacol. 1998 Dec;358(6):601-7. - Pubmed
  • Van Geldre LA, Timmermans JP, Lefebvre RA: L-citrulline recycling by argininosuccinate synthetase and lyase in rat gastric fundus. Eur J Pharmacol. 2002 Nov 29;455(2-3):149-60. - Pubmed
  • Zandvliet MM, Rothuizen J: Transient hyperammonemia due to urea cycle enzyme deficiency in Irish wolfhounds. J Vet Intern Med. 2007 Mar-Apr;21(2):215-8. - Pubmed
  • Takahashi H, Kagawa T, Kobayashi K, Hirabayashi H, Yui M, Begum L, Mine T, Takagi S, Saheki T, Shinohara Y: A case of adult-onset type II citrullinemia--deterioration of clinical course after infusion of hyperosmotic and high sugar solutions. Med Sci Monit. 2006 Feb;12(2):CS13-5. Epub 2006 Jan 26. - Pubmed
DTHybrid score 0.7247
NG,NG-dimethylarginine dimethylaminohydrolase 1
Name NG,NG-dimethylarginine dimethylaminohydrolase 1
Gene Name DDAH1
Pharmacological action unknown
Actions Not Available
References
  • Mishima T, Hamada T, Ui-Tei K, Takahashi F, Miyata Y, Imaki J, Suzuki H, Yamashita K: Expression of DDAH1 in chick and rat embryos. Brain Res Dev Brain Res. 2004 Feb 20;148(2):223-32. - Pubmed
  • Tran CT, Fox MF, Vallance P, Leiper JM: Chromosomal localization, gene structure, and expression pattern of DDAH1: comparison with DDAH2 and implications for evolutionary origins. Genomics. 2000 Aug 15;68(1):101-5. - Pubmed
  • Arrigoni FI, Vallance P, Haworth SG, Leiper JM: Metabolism of asymmetric dimethylarginines is regulated in the lung developmentally and with pulmonary hypertension induced by hypobaric hypoxia. Circulation. 2003 Mar 4;107(8):1195-201. - Pubmed
DTHybrid score 1.0208
Ornithine carbamoyltransferase, mitochondrial
Name Ornithine carbamoyltransferase, mitochondrial
Gene Name OTC
Pharmacological action unknown
Actions Not Available
References
  • Quintero MJ, Muro-Pastor AM, Herrero A, Flores E: Arginine catabolism in the cyanobacterium Synechocystis sp. Strain PCC 6803 involves the urea cycle and arginase pathway. J Bacteriol. 2000 Feb;182(4):1008-15. - Pubmed
  • Morizono H, Cabrera-Luque J, Shi D, Gallegos R, Yamaguchi S, Yu X, Allewell NM, Malamy MH, Tuchman M: Acetylornithine transcarbamylase: a novel enzyme in arginine biosynthesis. J Bacteriol. 2006 Apr;188(8):2974-82. - Pubmed
DTHybrid score 1.6283
Nitric-oxide synthase, brain
Name Nitric-oxide synthase, brain
Gene Name NOS1
Pharmacological action unknown
Actions Not Available
References
  • Kominami S, Yamazaki T, Koga T, Hori H: EPR studies on the photo-induced intermediates of ferric NO complexes of rat neuronal nitric oxide synthase trapped at low temperature. J Biochem (Tokyo). 1999 Oct;126(4):756-61. - Pubmed
  • Giraldi-Guimaraes A, Tenorio F, Bruning G, Mayer B, Mendez-Otero R, Cavalcante LA: Nitric oxide synthase expression in the opossum superior colliculus: a histochemical, immunohistochemical and biochemical study. Brain Behav Evol. 1999 Dec;54(6):303-13. - Pubmed
  • Perry JM, Zhao Y, Marletta MA: Cu2+ and Zn2+ inhibit nitric-oxide synthase through an interaction with the reductase domain. J Biol Chem. 2000 May 12;275(19):14070-6. - Pubmed
  • Adak S, Wang Q, Stuehr DJ: Arginine conversion to nitroxide by tetrahydrobiopterin-free neuronal nitric-oxide synthase. Implications for mechanism. J Biol Chem. 2000 Oct 27;275(43):33554-61. - Pubmed
  • Yu W, Juang S, Lee J, Liu T, Cheng J: Decrease of neuronal nitric oxide synthase in the cerebellum of aged rats. Neurosci Lett. 2000 Sep 8;291(1):37-40. - Pubmed
DTHybrid score 1.4742
Nitric oxide synthase, inducible
Name Nitric oxide synthase, inducible
Gene Name NOS2
Pharmacological action unknown
Actions Not Available
References
  • Cunningham JM, Rayne RC: Radiochemical measurement of NOS activity by conversion of [14C]L-arginine to citrulline using HPLC separation. Methods Mol Biol. 1998;100:75-81. - Pubmed
  • Keilhoff G, Reiser M, Stanarius A, Aoki E, Wolf G: Citrulline immunohistochemistry for demonstration of NOS activity in vivo and in vitro. Nitric Oxide. 2000 Aug;4(4):343-53. - Pubmed
  • Conrad KP, Powers RW, Davis AK, Novak J: Citrulline is not the major product using the standard - NOS activity
  • Knowles RG, Salter M: Measurement of NOS activity by conversion of radiolabeled arginine to citrulline using ion-exchange separation. Methods Mol Biol. 1998;100:67-73. - Pubmed
  • Yi GB, McClendon D, Desaiah D, Goddard J, Lister A, Moffitt J, Meer RK, deShazo R, Lee KS, Rockhold RW: Fire ant venom alkaloid, isosolenopsin A, a potent and selective inhibitor of neuronal nitric oxide synthase. Int J Toxicol. 2003 Mar-Apr;22(2):81-6. - Pubmed
DTHybrid score 1.7703
Nitric-oxide synthase, endothelial
Name Nitric-oxide synthase, endothelial
Gene Name NOS3
Pharmacological action unknown
Actions Not Available
References
  • Hayakawa H, Raij L: Relationship between hypercholesterolaemia, endothelial dysfunction and hypertension. J Hypertens. 1999 May;17(5):611-9. - Pubmed
  • Trovati M, Massucco P, Mattiello L, Costamagna C, Aldieri E, Cavalot F, Anfossi G, Bosia A, Ghigo D: Human vascular smooth muscle cells express a constitutive nitric oxide synthase that insulin rapidly activates, thus increasing guanosine 3':5'-cyclic monophosphate and adenosine 3':5'-cyclic monophosphate concentrations. Diabetologia. 1999 Jul;42(7):831-9. - Pubmed
  • McDuffie JE, Coaxum SD, Maleque MA: 5-hydroxytryptamine evokes endothelial nitric oxide synthase activation in bovine aortic endothelial cell cultures. Proc Soc Exp Biol Med. 1999 Sep;221(4):386-90. - Pubmed
  • Tan E, Gurjar MV, Sharma RV, Bhalla RC: Estrogen receptor-alpha gene transfer into bovine aortic endothelial cells induces eNOS gene expression and inhibits cell migration. Cardiovasc Res. 1999 Aug 15;43(3):788-97. - Pubmed
  • Abu-Soud HM, Ichimori K, Presta A, Stuehr DJ: Electron transfer, oxygen binding, and nitric oxide feedback inhibition in endothelial nitric-oxide synthase. J Biol Chem. 2000 Jun 9;275(23):17349-57. - Pubmed
DTHybrid score 1.87
Protein-arginine deiminase type-6
Name Protein-arginine deiminase type-6
Gene Name PADI6
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 1.0205
Protein-arginine deiminase type-1
Name Protein-arginine deiminase type-1
Gene Name PADI1
Pharmacological action unknown
Actions Not Available
References
  • Iida A, Nakamura Y: Identification of 45 novel SNPs in the 83-kb region containing peptidylarginine deiminase types 1 and 3 loci on chromosomal band 1p36.13. J Hum Genet. 2004;49(7):387-90. Epub 2004 May 19. - Pubmed
DTHybrid score 1.0254
Protein-arginine deiminase type-3
Name Protein-arginine deiminase type-3
Gene Name PADI3
Pharmacological action unknown
Actions Not Available
References
  • Dong S, Kanno T, Yamaki A, Kojima T, Shiraiwa M, Kawada A, Mechin MC, Chavanas S, Serre G, Simon M, Takahara H: NF-Y and Sp1/Sp3 are involved in the transcriptional regulation of the peptidylarginine deiminase type III gene (PADI3) in human keratinocytes. Biochem J. 2006 Aug 1;397(3):449-59. - Pubmed
  • Iida A, Nakamura Y: Identification of 45 novel SNPs in the 83-kb region containing peptidylarginine deiminase types 1 and 3 loci on chromosomal band 1p36.13. J Hum Genet. 2004;49(7):387-90. Epub 2004 May 19. - Pubmed
  • Kanno T, Kawada A, Yamanouchi J, Yosida-Noro C, Yoshiki A, Shiraiwa M, Kusakabe M, Manabe M, Tezuka T, Takahara H: Human peptidylarginine deiminase type III: molecular cloning and nucleotide sequence of the cDNA, properties of the recombinant enzyme, and immunohistochemical localization in human skin. J Invest Dermatol. 2000 Nov;115(5):813-23. - Pubmed
DTHybrid score 1.0249
Protein-arginine deiminase type-2
Name Protein-arginine deiminase type-2
Gene Name PADI2
Pharmacological action unknown
Actions Not Available
References
  • Dong S, Kojima T, Shiraiwa M, Mechin MC, Chavanas S, Serre G, Simon M, Kawada A, Takahara H: Regulation of the expression of peptidylarginine deiminase type II gene (PADI2) in human keratinocytes involves Sp1 and Sp3 transcription factors. J Invest Dermatol. 2005 May;124(5):1026-33. - Pubmed
DTHybrid score 1.0233
Protein-arginine deiminase type-4
Name Protein-arginine deiminase type-4
Gene Name PADI4
Pharmacological action unknown
Actions Not Available
References
  • Wang Y, Wysocka J, Sayegh J, Lee YH, Perlin JR, Leonelli L, Sonbuchner LS, McDonald CH, Cook RG, Dou Y, Roeder RG, Clarke S, Stallcup MR, Allis CD, Coonrod SA: Human PAD4 regulates histone arginine methylation levels via demethylimination. Science. 2004 Oct 8;306(5694):279-83. Epub 2004 Sep 2. - Pubmed
  • Wysocka J, Allis CD, Coonrod S: Histone arginine methylation and its dynamic regulation. Front Biosci. 2006 Jan 1;11:344-55. - Pubmed
  • Yamamoto K, Yamada R: Genome-wide single nucleotide polymorphism analyses of rheumatoid arthritis. J Autoimmun. 2005;25 Suppl:12-5. Epub 2005 Nov 2. - Pubmed
  • Chang X, Han J: Expression of peptidylarginine deiminase type 4 (PAD4) in various tumors. Mol Carcinog. 2006 Mar;45(3):183-96. - Pubmed
  • Okazaki Y, Suzuki A, Sawada T, Ohtake-Yamanaka M, Inoue T, Hasebe T, Yamada R, Yamamoto K: Identification of citrullinated eukaryotic translation initiation factor 4G1 as novel autoantigen in rheumatoid arthritis. Biochem Biophys Res Commun. 2006 Mar 3;341(1):94-100. Epub 2006 Jan 6. - Pubmed
DTHybrid score 1.6209

Predictions


Id Partner name Gene Name Score
2680 Argininosuccinate synthase argG 0.7247
3194 Argininosuccinate synthase argG 0.7247
383 Glycine amidinotransferase, mitochondrial GATM 0.1696
834 Arginase-2, mitochondrial ARG2 0.0607
235 High-affinity cationic amino acid transporter 1 SLC7A1 0.06
150 Cationic amino acid transporter 3 SLC7A3 0.06
58 Cationic amino acid transporter 4 SLC7A4 0.06
828 Phenylalanine-4-hydroxylase PAH 0.0584
3109 Phenylalanine-4-hydroxylase phhA 0.0584
2632 Adenylosuccinate synthetase purA 0.0534
3323 Adenylosuccinate synthetase purA 0.0534
3975 Adenylosuccinate synthetase ADSS 0.0534
4598 Adenylosuccinate synthetase Adss 0.0534
6817 Adenylosuccinate synthetase purA 0.0534
209 Aspartoacylase ASPA 0.0533
3979 Aspartoacylase-2 ACY3 0.0533
533 Aminoacylase-1 ACY1 0.0533
3976 Aspartyl-tRNA synthetase, mitochondrial DARS2 0.0533
3969 Multifunctional protein ADE2 [Includes: Phosphoribosylaminoimidazole- succinocarboxamide synthase PAICS 0.0533
3972 Adenylosuccinate synthetase isozyme 2 ADSS 0.0533
799 Aspartyl-tRNA synthetase, cytoplasmic DARS 0.0533
513 Calcium-binding mitochondrial carrier protein Aralar2 SLC25A13 0.0533
305 Mitochondrial aspartate-glutamate carrier protein SLC25A13 0.0533
262 Calcium-binding mitochondrial carrier protein Aralar1 SLC25A12 0.0533
315 Arginase-1 ARG1 0.0525
2617 Nitric oxide synthase oxygenase nos 0.0492
2701 Nitric oxide synthase oxygenase nos 0.0492
585 Aspartyl/asparaginyl beta-hydroxylase ASPH 0.0452
6151 Monocarboxylate transporter 10 SLC16A10 0.0447
3977 ASRGL1 protein ASRGL1 0.0438
242 Asparagine synthetase [glutamine-hydrolyzing] ASNS 0.043
3971 CAD protein [Includes: Glutamine-dependent carbamoyl-phosphate synthase CAD 0.0395
1671 Excitatory amino acid transporter 3 SLC1A1 0.0393
3877 Growth-inhibiting protein 18 GIG18 0.0373
499 Arginine decarboxylase ADC 0.0366
577 Argininosuccinate lyase ASL 0.0363
426 Aspartate aminotransferase, mitochondrial GOT2 0.0341
586 Aspartate aminotransferase, cytoplasmic GOT1 0.0333
3981 Ornithine decarboxylase antizyme 3 OAZ3 0.0307
3980 Ornithine decarboxylase antizyme 2 OAZ2 0.0307
224 Mitochondrial ornithine transporter 1 SLC25A15 0.0307
285 Mitochondrial ornithine transporter 2 SLC25A2 0.0307
410 Ornithine decarboxylase antizyme OAZ1 0.0306
3978 Adenylosuccinate synthetase isozyme 1 ADSSL1 0.0289
134 Tryptophan 5-hydroxylase 1 TPH1 0.0284
619 Low-affinity cationic amino acid transporter 2 SLC7A2 0.0257
5682 Ribonuclease pancreatic RNASE1 0.0224
298 Renin REN 0.0221
472 Ornithine aminotransferase, mitochondrial OAT 0.0209
833 Organic cation/carnitine transporter 1 SLC22A4 0.0204
864 Gag-Pol polyprotein gag-pol 0.0197
2237 Gag-Pol polyprotein gag-pol 0.0197
2326 Gag-Pol polyprotein gag-pol 0.0197
2451 Gag-Pol polyprotein gag-pol 0.0197
2901 Gag-Pol polyprotein gag-pol 0.0197
3165 Gag-Pol polyprotein gag-pol 0.0197
3722 Gag-Pol polyprotein gag-pol 0.0197
6306 Gag-Pol polyprotein gag-pol 0.0197
6624 Gag-Pol polyprotein gag-pol 0.0197
676 Tyrosine 3-monooxygenase TH 0.0186
118 Organic cation/carnitine transporter 2 SLC22A5 0.0176
6447 Guanine nucleotide-binding protein G(t) subunit alpha-1 GNAT1 0.0164
2675 Pteridine reductase 1 PTR1 0.0144
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0136
6144 Solute carrier family 22 member 2 SLC22A2 0.0132
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.0125
340 Apoptotic protease-activating factor 1 APAF1 0.0122
377 Beta-adrenergic receptor kinase 1 ADRBK1 0.0114
825 Arsenical pump-driving ATPase ASNA1 0.0114
3435 Arsenical pump-driving ATPase arsA 0.0114
225 NEDD8-activating enzyme E1 regulatory subunit NAE1 0.0114
733 Activin receptor type 1B ACVR1B 0.0114
745 Anti-Muellerian hormone type-2 receptor AMHR2 0.0114
483 A-Raf proto-oncogene serine/threonine-protein kinase ARAF 0.0114
2105 ATP-binding cassette sub-family G member 1 ABCG1 0.0114
486 Serine/threonine-protein kinase ALS2CR7 CDK15 0.0114
21 Beta-adrenergic receptor kinase 2 ADRBK2 0.0114
154 AFG3-like protein 2 AFG3L2 0.0114
510 Serine/threonine-protein kinase receptor R3 ACVRL1 0.0114
395 ALK tyrosine kinase receptor Not Available 0.0114
822 Aldose reductase AKR1B1 0.0112
2360 Dihydroneopterin aldolase folB 0.0107
2939 Peptide methionine sulfoxide reductase msrA msrA 0.0102
2888 DNA-repair protein XRCC4 XRCC4 0.0102
2906 Coatomer subunit gamma COPG 0.0102
776 Bile salt export pump ABCB11 0.0099
821 Acetyl-coenzyme A synthetase 2-like, mitochondrial ACSS1 0.0098
704 Long-chain-fatty-acid--CoA ligase 1 ACSL1 0.0098
386 Acetyl-coenzyme A synthetase, cytoplasmic ACSS2 0.0098
297 Adenylate cyclase type 1 ADCY1 0.0098
289 Cytosolic purine 5'-nucleotidase NT5C2 0.0095
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0093
292 Activin receptor type-1 ACVR1 0.0093
849 Activated CDC42 kinase 1 TNK2 0.0093
2090 Toll-like receptor 2 TLR2 0.0091
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.0087
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0085
484 Tyrosine-protein kinase ABL2 ABL2 0.0084
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0083
2433 Capsid protein P40 UL80 0.0082
3569 Capsid protein P40 BVRF2 0.0082
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0081
1588 Multidrug resistance protein 1 ABCB1 0.008
4120 NADPH--cytochrome P450 reductase POR 0.0078
20 Prostaglandin G/H synthase 1 PTGS1 0.0077
6021 Adenosine kinase ADK 0.0075
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0074
661 ADP/ATP translocase 1 SLC25A4 0.0072
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0071
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.007
2297 Genome polyprotein Not Available 0.0069
2322 Genome polyprotein Not Available 0.0069
2694 Genome polyprotein Not Available 0.0069
2719 Genome polyprotein Not Available 0.0069
2860 Genome polyprotein Not Available 0.0069
2928 Genome polyprotein Not Available 0.0069
3160 Genome polyprotein Not Available 0.0069
3260 Genome polyprotein Not Available 0.0069
4783 Genome polyprotein Not Available 0.0069
5726 Genome polyprotein Not Available 0.0069
5779 Genome polyprotein Not Available 0.0069
5867 Genome polyprotein Not Available 0.0069
6253 Genome polyprotein Not Available 0.0069
6301 Genome polyprotein Not Available 0.0069
6380 Genome polyprotein Not Available 0.0069
6381 Genome polyprotein Not Available 0.0069
6437 Genome polyprotein Not Available 0.0069
6520 Genome polyprotein Not Available 0.0069
6521 Genome polyprotein Not Available 0.0069
6652 Genome polyprotein Not Available 0.0069
6734 Genome polyprotein Not Available 0.0069
6735 Genome polyprotein Not Available 0.0069
6736 Genome polyprotein Not Available 0.0069
6737 Genome polyprotein Not Available 0.0069
6738 Genome polyprotein Not Available 0.0069
6739 Genome polyprotein Not Available 0.0069
6744 Genome polyprotein Not Available 0.0069
6748 Genome polyprotein Not Available 0.0069
6894 Genome polyprotein Not Available 0.0069
6898 Genome polyprotein Not Available 0.0069
6030 Cytochrome P450 2B6 CYP2B6 0.0063
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0063
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0062
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0062
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0062
6168 Solute carrier family 22 member 16 SLC22A16 0.0062
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.006
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.006
290 Prostaglandin G/H synthase 2 PTGS2 0.0059
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0059
3947 Xanthine dehydrogenase/oxidase XDH 0.0048
1898 Cytochrome P450 1B1 CYP1B1 0.0048
4512 Cytochrome P450 3A4 CYP3A4 0.0047
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0047
4119 Cytochrome P450 2D6 CYP2D6 0.0046
3573 2,4-dienoyl-CoA reductase [NADPH] fadH 0.0045
6137 Multidrug resistance-associated protein 6 ABCC6 0.0045
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0043
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0043
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0043
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0043
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0043
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0043
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0043
6148 Multidrug resistance-associated protein 7 ABCC10 0.0043
817 DNA topoisomerase 2-alpha TOP2A 0.0039
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0039
2775 Dihydroorotate dehydrogenase pyrD 0.0038
4531 Putative ketoacyl reductase actIII 0.0037
862 Multidrug resistance-associated protein 1 ABCC1 0.0035
3811 Cytochrome P450 19A1 CYP19A1 0.0034
3102 Flavohemoprotein hmp 0.0033
4969 Flavohemoprotein hmp 0.0033
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0032
5075 Sulfite reductase [NADPH] flavoprotein alpha-component cysJ 0.0032
5073 Ferredoxin--NADP reductase petH 0.0032
5076 Ferredoxin--NADP reductase fpr 0.0032
5119 Ferredoxin--NADP reductase petH 0.0032
5121 Ferredoxin--NADP reductase fpr 0.0032
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0031
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0031
6268 Hydroxyacid oxidase 1 HAO1 0.003
810 Heme oxygenase 1 HMOX1 0.003
3391 Heme oxygenase 1 pbsA1 0.003
5718 Cytochrome P450 2A6 CYP2A6 0.0029
605 Fumarate reductase flavoprotein subunit frdA 0.0028
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0028
3673 Fumarate reductase flavoprotein subunit fccA 0.0028
4912 Fumarate reductase flavoprotein subunit ifcA 0.0028
6549 Fumarate reductase flavoprotein subunit frdA 0.0028
4757 Cytochrome P450 2C9 CYP2C9 0.0028
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0027
260 Cytochrome P450 51 ERG11 0.0027
761 Cytochrome P450 51 ERG11 0.0027
3163 Cytochrome P450 51 cyp51 0.0027
654 Flavin reductase BLVRB 0.0027
6013 Cytochrome P450 2E1 CYP2E1 0.0026
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0026
4954 Soluble cytochrome b558 Not Available 0.0026
4934 Cytochrome c-551 nirM 0.0026
5218 Cytochrome c-551 nirM 0.0026
4905 Cytochrome c2 Not Available 0.0026
4939 Cytochrome c2 cycA 0.0026
4964 Cytochrome c2 cycA 0.0026
4979 Cytochrome c2 cycA 0.0026
6673 Cytochrome c2 cycA 0.0026
4925 Cytochrome c-type protein SHP shp 0.0026
4936 Cytochrome c2 iso-2 Not Available 0.0026
4916 Cyanoglobin glbN 0.0026
4994 Hemoglobin-like protein HbO glbO 0.0026
4915 Cytochrome c-550 psbV 0.0026
4959 Cytochrome c-550 psbV 0.0026
5216 Cytochrome c-550 psbV 0.0026
4943 Cytochrome c6 petJ 0.0026
4998 Hemoglobin-like protein yjbI yjbI 0.0026
4975 Cytochrome c-556 RPA3973 0.0026
4947 Bacterial hemoglobin vhb 0.0026
4942 Diheme cytochrome c napB napB 0.0026
3116 Bacterioferritin bfr 0.0026
4906 Bacterioferritin bfr 0.0026
4965 Bacterioferritin bfr 0.0026
5000 HemO hemO 0.0026
4981 Iron-starvation protein PigA pigA 0.0026
4984 Neuroglobin NGB 0.0026
4961 Hemophore HasA hasA 0.0026
4910 Cytoglobin CYGB 0.0026
4909 CooA protein cooA 0.0026
4907 Cytochrome c-L moxG 0.0026
6865 Cytochrome c-L moxG 0.0026
4935 Cytochrome c-554 cycA1 0.0026
644 Heme oxygenase 2 HMOX2 0.0026
4982 Heme oxygenase 2 pbsA2 0.0026
4971 Nonaheme cytochrome c hmcA 0.0026
4976 Apocytochrome f petA 0.0026
6407 Apocytochrome f petA 0.0026
4960 Putative cytochrome P450-family protein SCO7417 0.0026
4937 Cytochrome oxidase subunit II rcoxA 0.0026
4972 P450cin cinA 0.0026
4764 Cytochrome P450 165C4 CYP165C4 0.0026
4989 Cytochrome c551 peroxidase ccp 0.0026
5222 Cytochrome c551 peroxidase ccpA 0.0026
4904 Cytochrome c family protein GSU1996 0.0026
4931 Cytochrome P450 167A1 CYP167A1 0.0026
4922 Cytochrome c, putative SO_4144 0.0026
4999 Cytochrome P450 165B3 CYP165B3 0.0026
4952 Catalase/peroxidase katA 0.0026
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0026
4926 Heme-based aerotactic transducer hemAT hemAT 0.0026
4903 Methyl-accepting chemotaxis protein Tar4 0.0026
3093 Catalase HPII katE 0.0026
4993 Hydroxylamine oxidoreductase hao1 0.0026
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0026
4037 Hypothetical protein GPX1 0.0025
4297 Hypothetical protein SP_1951 0.0025
4521 Hypothetical protein BC_2969 0.0025
4540 Hypothetical protein TM_1070 0.0025
4555 Hypothetical protein MT1739 0.0025
4569 Hypothetical protein mshD 0.0025
4578 Hypothetical protein PA3270 0.0025
4747 Hypothetical protein PA3967 0.0025
5177 Hypothetical protein TM_0096 0.0025
5194 Hypothetical protein PA1204 0.0025
5240 Hypothetical protein Rv2991 0.0025
5370 Hypothetical protein TM_1158 0.0025
5710 Hypothetical protein Tb927.5.1360 0.0025
4545 Molybdopterin-converting factor subunit 2 moaE 0.0025
4106 Guanylate kinase GUK1 0.0025
4516 Guanylate kinase gmk 0.0025
4522 Arginine N-succinyltransferase subunit alpha astA 0.0025
4527 Putative hydrolase ycdX ycdX 0.0025
4536 Transcriptional regulator, IclR family TM_0065 0.0025
4529 Oxalate decarboxylase oxdC oxdC 0.0025
2501 Protein ygbM ygbM 0.0025
4546 Aminotransferase, putative TM_1131 0.0025
4514 Citrate lyase beta subunit-like protein citE 0.0025
4781 Citrate lyase beta subunit-like protein DR_1240 0.0025
4524 Mannose-6-phosphate isomerase yvyI 0.0025
4547 Iron binding protein FbpA fbpA 0.0025
4538 Hypothetical protein VC1899 VC_1899 0.0025
4548 Gyrase B gyrB 0.0025
658 Para-aminobenzoate synthase component 1 pabB 0.0025
4526 Oligopeptide ABC transporter, periplasmic oligopeptide-binding protein TM_1223 0.0025
4535 Glutaconyl-CoA decarboxylase subunit alpha gcdA 0.0025
4515 Peripheral plasma membrane protein CASK CASK 0.0025
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0024
6016 Cytochrome P450 2C19 CYP2C19 0.0023
5201 FMN-binding protein DvMF_2023 0.0023
3293 Flavodoxin Not Available 0.0023
4614 Flavodoxin DVU_2680 0.0023
5172 Flavodoxin isiB 0.0023
5173 Flavodoxin isiB 0.0023
5182 Flavodoxin fldA 0.0023
5131 PhzG phzG 0.0023
5181 Hypothetical protein yhdA azr 0.0023
5198 Flavodoxin-1 fldA 0.0023
5170 Epidermin decarboxylase epiD 0.0023
5179 Probable aromatic acid decarboxylase pad1 0.0023
5175 Hypothetical protein SMU.260 SMU_260 0.0023
5202 Nitroreductase family protein BC_1844 0.0023
5197 Trp repressor binding protein WrbA, putative DR_A0214 0.0023
5200 NADH dehydrogenase nox 0.0023
5193 Phenazine biosynthesis protein phzG phzG 0.0023
5178 Protein nrdI nrdI 0.0023
5191 Morphinone reductase morB 0.0023
5190 Rubredoxin-oxygen oxidoreductase roo 0.0023
2586 Isopentenyl-diphosphate Delta-isomerase idi 0.0023
5187 Isopentenyl-diphosphate delta-isomerase fni 0.0023
5199 Isopentenyl-diphosphate delta-isomerase fni 0.0023
4405 Nitric oxide reductase fprA 0.0023
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0023
4990 PpcA ppcA 0.0022
4385 Cytochrome c' Not Available 0.0022
4967 Cytochrome c' cycA 0.0022
5038 Cytochrome c' Not Available 0.0022
5223 Cytochrome c' cycP 0.0022
3570 Cytochrome P450 152A1 cypC 0.0022
4289 Cytochrome P450 TT_P0059 0.0022
6262 Cytochrome P450 staP 0.0022
4948 Cytochrome c-553 Not Available 0.0022
4992 Cytochrome c peroxidase Not Available 0.0022
4923 Cytochrome c3 DvMF_2499 0.0022
4945 Cytochrome c3 Not Available 0.0022
4949 Cytochrome c3 DVU_3171 0.0022
4968 Cytochrome c3 cytc3 0.0022
4997 Cytochrome c3 SO_2727 0.0022
5219 Cytochrome c3 cyd 0.0022
4920 Peroxidase/catalase katG 0.0022
4813 Heme oxygenase hmuO 0.0022
5769 Heme oxygenase Not Available 0.0022
2119 Cytochrome b5 CYB5A 0.0022
4902 Nine-heme cytochrome c Ddes_2038 0.0022
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0022
3189 High-molecular-weight cytochrome c hmcA 0.0022
3375 Acidic cytochrome c3 Not Available 0.0022
4988 Sulfite oxidase, mitochondrial SUOX 0.0022
2915 Sensor protein fixL fixL 0.0022
4944 Sensor protein fixL fixL 0.0022
4496 C-terminal-binding protein 1 CTBP1 0.0022
3237 Beta-lactamase OXA-2 bla 0.0022
56 Delta-aminolevulinic acid dehydratase ALAD 0.0022
2356 Delta-aminolevulinic acid dehydratase hemB 0.0022
3613 Delta-aminolevulinic acid dehydratase hemB 0.0022
3674 Delta-aminolevulinic acid dehydratase hemB 0.0022
4532 Gephyrin GPHN 0.0022
4542 Glutaminase 1 glsA1 0.0022
4544 Glutaminase 1 glsA1 0.0022
2929 (S)-2-haloacid dehalogenase dhlB 0.0022
2995 (S)-2-haloacid dehalogenase Not Available 0.0022
4533 Glyoxalase family protein BC_1747 0.0022
3759 Glutathione S-transferase gst 0.0022
4541 Glutathione S-transferase GST 0.0022
4528 Phenazine biosynthesis protein PhzD phzD1 0.0022
4517 Probable butyrate kinase 2 buk2 0.0022
3261 Signal recognition particle protein ffh 0.0022
5346 Oxidoreductase, aldo/keto reductase family TM_1009 0.0021
5326 Oxidoreductase, short chain dehydrogenase/reductase family TM_0441 0.0021
5332 MtdA bifunctional protein mtdA 0.0021
3772 3-oxoacyl-[acyl-carrier-protein] reductase fabG 0.0021
5342 NADH-dependent butanol dehydrogenase, putative TM_0820 0.0021
5157 Dehydrogenase/reductase SDR family member 11 DHRS11 0.0021
3778 NAD(P) transhydrogenase subunit beta pntB 0.0021
5322 Oxidoreductase ydhF ydhF 0.0021
4403 Protein iolS iolS 0.0021
5330 General stress protein 69 yhdN 0.0021
5333 Alcohol dehydrogenase, iron-containing TM_0920 0.0021
5343 NADP-dependent fatty aldehyde dehydrogenase aldH 0.0021
4386 Hemoglobin-like protein HbN glbN 0.002
3670 Soluble cytochrome b562 precursor cybC 0.002
3291 Cytochrome c-552 cycA 0.002
4927 Cytochrome c-552 nrfA 0.002
4938 Cytochrome c-552 cycA 0.002
4953 Cytochrome c-552 nrfA 0.002
5217 Cytochrome c-552 cycM 0.002
3411 Cytochrome P450 121 cyp121 0.002
4503 NADPH-flavin oxidoreductase frp 0.002
5189 Trimethylamine dehydrogenase tmd 0.002
4836 Ferredoxin-dependent glutamate synthase 2 gltS 0.002
5206 Phosphopantothenoylcysteine decarboxylase PPCDC 0.002
3680 Dihydroorotate dehydrogenase A pyrDA 0.002
4407 FMN-dependent NADH-azoreductase azoR 0.002
5169 FMN-dependent NADH-azoreductase azoR 0.002
3766 Pyridoxamine 5'-phosphate oxidase pdxH 0.002
5176 YtnJ moxC 0.002
3507 Chorismate synthase aroC 0.002
5171 Chorismate synthase aroC 0.002
3467 Methylglyoxal synthase mgsA 0.002
3583 6-phosphogluconolactonase pgl 0.002
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0019
3127 Nitrite reductase nirS 0.0019
3284 Nitrite reductase nirS 0.0019
3221 Cytochrome c4 cc4 0.0019
4878 Glycoprotein hormones alpha chain CGA 0.0019
1052 Cytotoxic T-lymphocyte protein 4 CTLA4 0.0019
1072 Granzyme B GZMB 0.0019
4877 Beta-mannanase man 0.0019
4869 Major capsid protein A430L 0.0019
4871 Endo-beta-N-acetylglucosaminidase F3 endOF3 0.0019
4850 Beta-2-glycoprotein 1 APOH 0.0019
4880 Membrane cofactor protein CD46 0.0019
1563 Platelet glycoprotein Ib alpha chain GP1BA 0.0019
4856 CD209 antigen CD209 0.0019
4189 Alpha-galactosidase A GLA 0.0019
4889 Ig epsilon chain C region IGHE 0.0019
4852 Reticulon-4 receptor RTN4R 0.0019
4845 ADAM 33 ADAM33 0.0019
757 Fusion glycoprotein F0 F 0.0019
4875 Fusion glycoprotein F0 F 0.0019
4721 Beta-1,4-mannanase manA 0.0019
1354 Beta-glucuronidase GUSB 0.0019
442 Envelope glycoprotein gp41 0.0019
4859 Envelope glycoprotein env 0.0019
3352 Structural polyprotein Not Available 0.0019
3628 Structural polyprotein Not Available 0.0019
4892 Structural polyprotein Not Available 0.0019
4882 Dipeptidyl aminopeptidase-like protein 6 DPP6 0.0019
2525 3-phosphoshikimate 1-carboxyvinyltransferase aroA 0.0019
3201 3-phosphoshikimate 1-carboxyvinyltransferase aroA 0.0019
84 Nuclear receptor 0B1 NR0B1 0.0019
4484 2,5-diketo-D-gluconic acid reductase A dkgA 0.0019
2230 Catalase CAT 0.0019
3249 Catalase katA 0.0019
3625 Catalase katA 0.0019
4539 Catalase katA 0.0019
4941 Catalase katB 0.0019
6608 Serine/threonine-protein kinase Sgk1 SGK1 0.0018
4608 Putative cytochrome P450 SCO1207 0.0018
4963 Putative cytochrome P450 SCO2884 0.0018
6254 Putative cytochrome P450 SCO6998 0.0018
4582 Putative pteridine reductase 2 ptr2 0.0018
1799 Glucose-6-phosphate 1-dehydrogenase G6PD 0.0018
2630 Glucose-6-phosphate 1-dehydrogenase zwf 0.0018
5328 Prostaglandin F synthase Tb11.02.2310 0.0018
2305 Isocitrate dehydrogenase [NADP] cytoplasmic IDH1 0.0018
2636 Shikimate dehydrogenase aroE 0.0018
3515 Shikimate dehydrogenase aroE 0.0018
2286 Isocitrate dehydrogenase [NADP] icd 0.0018
2302 Isocitrate dehydrogenase [NADP] icd 0.0018
2771 Isocitrate dehydrogenase [NADP] icd 0.0018
3446 NADP-dependent alcohol dehydrogenase adh 0.0018
2375 ADP-L-glycero-D-manno-heptose-6-epimerase hldD 0.0018
4628 NADP-dependent glyceraldehyde-3-phosphate dehydrogenase gapN 0.0018
989 L-xylulose reductase DCXR 0.0018
729 GDP-L-fucose synthetase TSTA3 0.0018
3463 GDP-L-fucose synthetase fcl 0.0018
2688 Peptide deformylase def 0.0018
2708 Peptide deformylase def 0.0018
3004 Peptide deformylase def 0.0018
4337 Peptide deformylase def 0.0018
4338 Peptide deformylase def 0.0018
5368 Peptide deformylase def 0.0018
5371 Peptide deformylase def 0.0018
6375 Peptide deformylase def 0.0018
6378 Peptide deformylase def 0.0018
6379 Peptide deformylase def 0.0018
6776 Peptide deformylase def 0.0018
6900 Peptide deformylase def 0.0018
4534 Cytohesin-2 CYTH2 0.0018
4366 Riboflavin kinase/FMN adenylyltransferase TM_0857 0.0018
2972 6-deoxyerythronolide B hydroxylase eryF 0.0018
5180 L(+)-mandelate dehydrogenase mdlB 0.0017
2548 Subtilisin Carlsberg apr 0.0017
469 Annexin A1 ANXA1 0.0017
4269 Hypoxanthine-guanine phosphoribosyltransferase, putative HGPRTase 0.0017
380 Cytochrome P450 17A1 CYP17A1 0.0017
3062 Aspartate-semialdehyde dehydrogenase asd 0.0017
6297 Prostaglandin reductase 1 PTGR1 0.0017
6862 Aldo-keto reductase family 1 member B10 AKR1B10 0.0017
408 Riboflavin kinase RFK 0.0017
685 Oxygen-insensitive NADPH nitroreductase nfsA 0.0017
6945 Oxygen-insensitive NADPH nitroreductase rdxA 0.0017
793 T-cell surface antigen CD2 CD2 0.0017
4861 Interleukin-6 receptor alpha chain IL6R 0.0017
4193 Atrial natriuretic peptide clearance receptor NPR3 0.0017
119 Carcinoembryonic antigen-related cell adhesion molecule 1 CEACAM1 0.0017
3837 Cytokine receptor common beta chain CSF2RB 0.0017
2261 Major NAD(P)H-flavin oxidoreductase Not Available 0.0017
4857 Zinc-alpha-2-glycoprotein AZGP1 0.0016
1184 Interferon beta IFNB1 0.0016
1379 Interleukin-12 subunit beta IL12B 0.0016
6858 Inactive carboxylesterase 4 CES1P1 0.0016
4890 Hemagglutinin HA 0.0016
6566 Hemagglutinin Not Available 0.0016
1507 Cytochrome c CYCS 0.0016
2936 Oxygen-insensitive NAD(P)H nitroreductase nfnB 0.0016
5184 Oxygen-insensitive NAD(P)H nitroreductase nfnB 0.0016
5325 2,4-dienoyl-CoA reductase, mitochondrial DECR1 0.0016
518 Peroxidase/catalase T katG 0.0016
203 Pyridoxine-5'-phosphate oxidase PNPO 0.0016
693 Hemoglobin subunit beta HBB 0.0016
1124 Sepiapterin reductase SPR 0.0016
4284 Pentaerythritol tetranitrate reductase onr 0.0016
635 Estradiol 17-beta-dehydrogenase 8 HSD17B8 0.0015
666 NADP-dependent malic enzyme ME1 0.0015
5112 Benzoate 1,2-dioxygenase electron transfer component benC 0.0015
5078 Amine oxidase, flavin-containing PSPTO1126 0.0015
5122 Mersacidin decarboxylase mrsD 0.0015
526 Thioredoxin reductase trxB 0.0015
3767 Thioredoxin reductase trxB 0.0015
5102 4-cresol dehydrogenase [hydroxylating] flavoprotein subunit pchF 0.0015
5115 FkbI fkbI 0.0015
3763 5,10-methylenetetrahydrofolate reductase metF 0.0015
3918 5,10-methylenetetrahydrofolate reductase MTHFR 0.0015
5094 5,10-methylenetetrahydrofolate reductase metF 0.0015
5097 PROBABLE DIHYDROLIPOAMIDE DEHYDROGENASE LPDA lpdA 0.0015
5107 Alkyl hydroperoxide reductase subunit F ahpF 0.0015
5118 Alkyl hydroperoxide reductase subunit F ahpF 0.0015
5081 L-aspartate oxidase nadB 0.0015
5111 Phenylacetone monooxygenase pamO 0.0015
3133 UDP-galactopyranose mutase glf 0.0015
5099 UDP-galactopyranose mutase glf 0.0015
5114 Putative acyl-CoA dehydrogenase TT_C0779 0.0015
5095 Putidaredoxin reductase camA 0.0015
5109 Outer membrane protein p64k or PM-6 m-6 0.0015
5083 Cryptochrome DASH cry 0.0015
5100 Gamma-aminobutyrate metabolism dehydratase/isomerase abfD 0.0015
1410 Oxidoreductase HSD17B6 0.0015
4725 Oxidoreductase Not Available 0.0015
5124 Oxidoreductase Not Available 0.0015
1329 Apoptosis-inducing factor 1, mitochondrial AIFM1 0.0015
4200 Cytochrome P450 1A2 CYP1A2 0.0015
646 Malate dehydrogenase, cytoplasmic MDH1 0.0015
2159 Quinone oxidoreductase CRYZ 0.0015
2998 Sialic acid-binding Ig-like lectin 7 SIGLEC7 0.0015
6120 Cation-independent mannose-6-phosphate receptor IGF2R 0.0015
3140 Hemagglutinin-neuraminidase HN 0.0015
3609 Hemagglutinin-neuraminidase HN 0.0015
3444 Cyanovirin-N Not Available 0.0015
11 NAD(P) transhydrogenase, mitochondrial NNT 0.0015
1859 Prostatic acid phosphatase ACPP 0.0015
3258 Mannosyl-oligosaccharide alpha-1,2-mannosidase MSDC 0.0015
760 Fibroblast growth factor 1 FGF1 0.0015
4924 Cytochrome P450 2C8 CYP2C8 0.0015
3027 Streptavidin Not Available 0.0014
4787 Envelope glycoprotein gp160 env 0.0014
4820 Envelope glycoprotein gp160 env 0.0014
5727 Envelope glycoprotein gp160 env 0.0014
4666 Fucose-binding lectin PA-IIL lecB 0.0014
2372 Bifunctional tail protein 9 0.0014
500 Monocarboxylate transporter 4 SLC16A3 0.0014
468 Cytochrome P450 4A11 CYP4A11 0.0014
2298 Cytochrome P450-cam camC 0.0014
6031 Cytochrome P450 3A43 CYP3A43 0.0014
358 Cystathionine beta-synthase CBS 0.0014
18 High affinity immunoglobulin epsilon receptor subunit alpha FCER1A 0.0014
4486 Phenol 2-hydroxylase component B pheA2 0.0013
554 Low-density lipoprotein receptor LDLR 0.0013
2577 Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase MAN1B1 0.0013
4439 Ferredoxin reductase bphA4 0.0013
4477 Dihydrolipoyl dehydrogenase lpdV 0.0013
5077 Dihydrolipoyl dehydrogenase Not Available 0.0013
5117 Dihydrolipoyl dehydrogenase lpd 0.0013
852 Heparin cofactor 2 SERPIND1 0.0013
686 Aldo-keto reductase family 1 member C2 AKR1C2 0.0013
679 C-1-tetrahydrofolate synthase, cytoplasmic MTHFD1 0.0013
5072 N,N-dimethylglycine oxidase dmg 0.0013
667 Acyl-CoA dehydrogenase family member 8, mitochondrial ACAD8 0.0013
3506 Glutaryl-CoA dehydrogenase, mitochondrial GCDH 0.0013
6639 Peroxisomal acyl-coenzyme A oxidase 1 ACOX1 0.0013
440 Isovaleryl-CoA dehydrogenase, mitochondrial IVD 0.0013
5003 Acyl-CoA dehydrogenase, short-chain specific Not Available 0.0013
5091 UDP-N-acetylenolpyruvoylglucosamine reductase murB 0.0013
5093 UDP-N-acetylenolpyruvoylglucosamine reductase murB 0.0013
3247 2-oxopropyl-CoM reductase, carboxylating xecC 0.0013
2526 NADPH-ferredoxin reductase fprA fprA 0.0013
2268 Cholesterol oxidase choB 0.0013
2822 Cholesterol oxidase choA 0.0013
3594 Deoxyribodipyrimidine photo-lyase phr 0.0013
5079 Deoxyribodipyrimidine photo-lyase phrB 0.0013
5080 Deoxyribodipyrimidine photo-lyase phr 0.0013
2470 Pyruvate oxidase pox5 0.0013
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0013
3480 Mannan endo-1,4-beta-mannosidase manA 0.0013
64 Neuraminidase NA 0.0013
641 Neuraminidase NA 0.0013
2676 Neuraminidase NA 0.0013
3026 Neuraminidase NA 0.0013
3519 Neuraminidase NA 0.0013
6007 Neuraminidase NA 0.0013
1439 Lactotransferrin LTF 0.0013
595 Fibrinogen alpha chain FGA 0.0012
4440 NADH peroxidase npr 0.0012
1243 Cathepsin D CTSD 0.0012
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0012
3254 Bifunctional protein putA [Includes: Proline dehydrogenase putA 0.0012
2893 Glycine oxidase thiO 0.0012
3185 Medium-chain specific acyl-CoA dehydrogenase, mitochondrial ACADM 0.0012
958 Insulin-like growth factor 1 receptor IGF1R 0.0012
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0012
1782 Neutrophil gelatinase-associated lipocalin LCN2 0.0012
2430 Chondroitinase B cslB 0.0012
444 Alcohol dehydrogenase 1B ADH1B 0.0012
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0012
2581 Chondroitinase AC cslA 0.0012
6307 Ig gamma-2 chain C region IGHG2 0.0012
2823 Trypanothione reductase TPR 0.0012
2567 Thymidylate synthase thyX thyX 0.0012
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0011
6847 Lactase-phlorizin hydrolase LCT 0.0011
6500 Phospholipase A2 PLA2G1B 0.0011
2769 P-hydroxybenzoate hydroxylase pobA 0.0011
2809 P-hydroxybenzoate hydroxylase pobA 0.0011
126 D-lactate dehydrogenase dld 0.0011
3545 D-lactate dehydrogenase Not Available 0.0011
4510 D-lactate dehydrogenase ldhA 0.0011
178 NADH-cytochrome b5 reductase 3 CYB5R3 0.0011
812 Dihydrolipoyl dehydrogenase, mitochondrial DLD 0.0011
327 Glutathione reductase gor 0.0011
5110 Glutathione reductase GR2 0.0011
839 Short-chain specific acyl-CoA dehydrogenase, mitochondrial ACADS 0.0011
275 Arachidonate 5-lipoxygenase ALOX5 0.0011
871 Glucocorticoid receptor NR3C1 0.0011
2380 Monomeric sarcosine oxidase soxA 0.0011
3814 Complement C1r subcomponent C1R 0.0011
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0011
2207 Rhodopsin RHO 0.001
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.001
309 Antithrombin-III SERPINC1 0.001
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.001
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.001
6645 D-amino-acid oxidase DAO 0.001
365 Dihydrofolate reductase DHFR 0.001
2381 Dihydrofolate reductase DFR1 0.001
2833 Dihydrofolate reductase Not Available 0.001
2931 Dihydrofolate reductase folA 0.001
3544 Dihydrofolate reductase folA 0.001
3682 Dihydrofolate reductase folA 0.001
6642 Dihydrofolate reductase folA 0.001
6756 Dihydrofolate reductase dfrA 0.001
4785 Ig gamma-1 chain C region IGHG1 0.001
6024 Cytochrome P450 1A1 CYP1A1 0.0009
357 Carbonic anhydrase 2 CA2 0.0009
6106 Cytochrome P450 2C18 CYP2C18 0.0009
6107 Cytochrome P450 3A7 CYP3A7 0.0009
4118 Cytochrome P450 3A5 CYP3A5 0.0008
952 Dipeptidyl peptidase 4 DPP4 0.0008
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0008
714 Glutathione reductase, mitochondrial GSR 0.0008
4604 Liver carboxylesterase 1 CES1 0.0008
587 Serum albumin ALB 0.0007
3939 Amine oxidase [flavin-containing] B MAOB 0.0006
3923 Cholinesterase BCHE 0.0006
3941 Amine oxidase [flavin-containing] A MAOA 0.0006
↑