DT-Web

DB01686 - N,N-dimethylarginine


Identification
Name N,N-dimethylarginine
Accession Number DB01686 (EXPT01101)
Type small molecule
Description Asymmetric dimethylarginine (ADMA) is a naturally occurring chemical found in blood plasma. It is a metabolic by-product of continual protein modification processes in the cytoplasm of all human cells. It is closely related to L-arginine, a conditionally-essential amino acid. ADMA interferes with L-arginine in the production of nitric oxide, a key chemical to endothelial and hence cardiovascular health. [Wikipedia]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 202.2541
Groups experimental
Monoisotopic Weight 202.14297584
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Nitric oxide synthase, inducible
Name Nitric oxide synthase, inducible
Gene Name NOS2
Pharmacological action unknown
Actions Not Available
References
  • van Guldener C, Nanayakkara PW, Stehouwer CD: Review: Homocysteine and asymmetric dimethylarginine (ADMA): biochemically linked but differently related to vascular disease in chronic kidney disease. Clin Chem Lab Med. 2007 Oct 15;. - Pubmed
DTHybrid score 1.299
Nitric-oxide synthase, endothelial
Name Nitric-oxide synthase, endothelial
Gene Name NOS3
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 1.2641

Predictions


Id Partner name Gene Name Score
76 Nitric-oxide synthase, brain NOS1 0.3001
828 Phenylalanine-4-hydroxylase PAH 0.0416
3109 Phenylalanine-4-hydroxylase phhA 0.0416
2617 Nitric oxide synthase oxygenase nos 0.0285
2701 Nitric oxide synthase oxygenase nos 0.0285
134 Tryptophan 5-hydroxylase 1 TPH1 0.0284
298 Renin REN 0.0221
315 Arginase-1 ARG1 0.0198
864 Gag-Pol polyprotein gag-pol 0.0197
2237 Gag-Pol polyprotein gag-pol 0.0197
2326 Gag-Pol polyprotein gag-pol 0.0197
2451 Gag-Pol polyprotein gag-pol 0.0197
2901 Gag-Pol polyprotein gag-pol 0.0197
3165 Gag-Pol polyprotein gag-pol 0.0197
3722 Gag-Pol polyprotein gag-pol 0.0197
6306 Gag-Pol polyprotein gag-pol 0.0197
6624 Gag-Pol polyprotein gag-pol 0.0197
676 Tyrosine 3-monooxygenase TH 0.0186
6447 Guanine nucleotide-binding protein G(t) subunit alpha-1 GNAT1 0.0164
740 Argininosuccinate synthase ASS1 0.0137
865 Argininosuccinate synthase ASS1 0.0137
2680 Argininosuccinate synthase argG 0.0137
3194 Argininosuccinate synthase argG 0.0137
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0136
6144 Solute carrier family 22 member 2 SLC22A2 0.0132
2675 Pteridine reductase 1 PTR1 0.0128
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.0125
2360 Dihydroneopterin aldolase folB 0.0107
2939 Peptide methionine sulfoxide reductase msrA msrA 0.0102
2888 DNA-repair protein XRCC4 XRCC4 0.0102
2906 Coatomer subunit gamma COPG 0.0102
822 Aldose reductase AKR1B1 0.0102
577 Argininosuccinate lyase ASL 0.0101
1814 Protein-arginine deiminase type-4 PADI4 0.0094
2090 Toll-like receptor 2 TLR2 0.0091
834 Arginase-2, mitochondrial ARG2 0.0089
843 NG,NG-dimethylarginine dimethylaminohydrolase 1 DDAH1 0.0089
670 NG,NG-dimethylarginine dimethylaminohydrolase 2 DDAH2 0.0089
4066 Protein-arginine deiminase type-1 PADI1 0.0088
4068 Protein-arginine deiminase type-2 PADI2 0.0088
4067 Protein-arginine deiminase type-3 PADI3 0.0088
4065 Protein-arginine deiminase type-6 PADI6 0.0088
499 Arginine decarboxylase ADC 0.0083
2433 Capsid protein P40 UL80 0.0082
3569 Capsid protein P40 BVRF2 0.0082
336 Ornithine carbamoyltransferase, mitochondrial OTC 0.0082
58 Cationic amino acid transporter 4 SLC7A4 0.0077
150 Cationic amino acid transporter 3 SLC7A3 0.0077
235 High-affinity cationic amino acid transporter 1 SLC7A1 0.0077
2297 Genome polyprotein Not Available 0.0069
2322 Genome polyprotein Not Available 0.0069
2694 Genome polyprotein Not Available 0.0069
2719 Genome polyprotein Not Available 0.0069
2860 Genome polyprotein Not Available 0.0069
2928 Genome polyprotein Not Available 0.0069
3160 Genome polyprotein Not Available 0.0069
3260 Genome polyprotein Not Available 0.0069
4783 Genome polyprotein Not Available 0.0069
5726 Genome polyprotein Not Available 0.0069
5779 Genome polyprotein Not Available 0.0069
5867 Genome polyprotein Not Available 0.0069
6253 Genome polyprotein Not Available 0.0069
6301 Genome polyprotein Not Available 0.0069
6380 Genome polyprotein Not Available 0.0069
6381 Genome polyprotein Not Available 0.0069
6437 Genome polyprotein Not Available 0.0069
6520 Genome polyprotein Not Available 0.0069
6521 Genome polyprotein Not Available 0.0069
6652 Genome polyprotein Not Available 0.0069
6734 Genome polyprotein Not Available 0.0069
6735 Genome polyprotein Not Available 0.0069
6736 Genome polyprotein Not Available 0.0069
6737 Genome polyprotein Not Available 0.0069
6738 Genome polyprotein Not Available 0.0069
6739 Genome polyprotein Not Available 0.0069
6744 Genome polyprotein Not Available 0.0069
6748 Genome polyprotein Not Available 0.0069
6894 Genome polyprotein Not Available 0.0069
6898 Genome polyprotein Not Available 0.0069
20 Prostaglandin G/H synthase 1 PTGS1 0.0069
290 Prostaglandin G/H synthase 2 PTGS2 0.0056
6151 Monocarboxylate transporter 10 SLC16A10 0.0053
833 Organic cation/carnitine transporter 1 SLC22A4 0.0052
6030 Cytochrome P450 2B6 CYP2B6 0.0048
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0047
118 Organic cation/carnitine transporter 2 SLC22A5 0.0044
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0043
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0043
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0043
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0043
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0043
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0043
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0041
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0039
1588 Multidrug resistance protein 1 ABCB1 0.0037
4119 Cytochrome P450 2D6 CYP2D6 0.0036
4512 Cytochrome P450 3A4 CYP3A4 0.0036
6168 Solute carrier family 22 member 16 SLC22A16 0.0035
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0035
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0035
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0035
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0034
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0034
3811 Cytochrome P450 19A1 CYP19A1 0.0034
776 Bile salt export pump ABCB11 0.0033
1898 Cytochrome P450 1B1 CYP1B1 0.0032
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0032
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0031
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0031
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.003
5718 Cytochrome P450 2A6 CYP2A6 0.0029
4120 NADPH--cytochrome P450 reductase POR 0.0029
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0029
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0028
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0027
260 Cytochrome P450 51 ERG11 0.0027
761 Cytochrome P450 51 ERG11 0.0027
3163 Cytochrome P450 51 cyp51 0.0027
6013 Cytochrome P450 2E1 CYP2E1 0.0026
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0026
4757 Cytochrome P450 2C9 CYP2C9 0.0026
6137 Multidrug resistance-associated protein 6 ABCC6 0.0026
6148 Multidrug resistance-associated protein 7 ABCC10 0.0025
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0024
3947 Xanthine dehydrogenase/oxidase XDH 0.0024
6016 Cytochrome P450 2C19 CYP2C19 0.0023
817 DNA topoisomerase 2-alpha TOP2A 0.0023
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0022
862 Multidrug resistance-associated protein 1 ABCC1 0.002
84 Nuclear receptor 0B1 NR0B1 0.0019
469 Annexin A1 ANXA1 0.0017
380 Cytochrome P450 17A1 CYP17A1 0.0017
4998 Hemoglobin-like protein yjbI yjbI 0.0015
4934 Cytochrome c-551 nirM 0.0015
5218 Cytochrome c-551 nirM 0.0015
4905 Cytochrome c2 Not Available 0.0015
4939 Cytochrome c2 cycA 0.0015
4964 Cytochrome c2 cycA 0.0015
4979 Cytochrome c2 cycA 0.0015
6673 Cytochrome c2 cycA 0.0015
4943 Cytochrome c6 petJ 0.0015
4954 Soluble cytochrome b558 Not Available 0.0015
4936 Cytochrome c2 iso-2 Not Available 0.0015
4200 Cytochrome P450 1A2 CYP1A2 0.0015
4916 Cyanoglobin glbN 0.0015
4994 Hemoglobin-like protein HbO glbO 0.0015
4915 Cytochrome c-550 psbV 0.0015
4959 Cytochrome c-550 psbV 0.0015
5216 Cytochrome c-550 psbV 0.0015
4925 Cytochrome c-type protein SHP shp 0.0015
4947 Bacterial hemoglobin vhb 0.0015
4942 Diheme cytochrome c napB napB 0.0015
4984 Neuroglobin NGB 0.0015
4981 Iron-starvation protein PigA pigA 0.0015
3116 Bacterioferritin bfr 0.0015
4906 Bacterioferritin bfr 0.0015
4965 Bacterioferritin bfr 0.0015
4909 CooA protein cooA 0.0015
5000 HemO hemO 0.0015
4961 Hemophore HasA hasA 0.0015
4910 Cytoglobin CYGB 0.0015
4975 Cytochrome c-556 RPA3973 0.0015
4907 Cytochrome c-L moxG 0.0015
6865 Cytochrome c-L moxG 0.0015
4935 Cytochrome c-554 cycA1 0.0015
644 Heme oxygenase 2 HMOX2 0.0015
4982 Heme oxygenase 2 pbsA2 0.0015
4764 Cytochrome P450 165C4 CYP165C4 0.0015
4972 P450cin cinA 0.0015
4937 Cytochrome oxidase subunit II rcoxA 0.0015
4971 Nonaheme cytochrome c hmcA 0.0015
4960 Putative cytochrome P450-family protein SCO7417 0.0015
4989 Cytochrome c551 peroxidase ccp 0.0015
5222 Cytochrome c551 peroxidase ccpA 0.0015
4976 Apocytochrome f petA 0.0015
6407 Apocytochrome f petA 0.0015
4904 Cytochrome c family protein GSU1996 0.0015
4922 Cytochrome c, putative SO_4144 0.0015
4931 Cytochrome P450 167A1 CYP167A1 0.0015
4952 Catalase/peroxidase katA 0.0015
4999 Cytochrome P450 165B3 CYP165B3 0.0015
4926 Heme-based aerotactic transducer hemAT hemAT 0.0015
4993 Hydroxylamine oxidoreductase hao1 0.0015
3093 Catalase HPII katE 0.0015
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0015
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0015
4903 Methyl-accepting chemotaxis protein Tar4 0.0015
468 Cytochrome P450 4A11 CYP4A11 0.0014
6031 Cytochrome P450 3A43 CYP3A43 0.0014
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0013
4037 Hypothetical protein GPX1 0.0013
4297 Hypothetical protein SP_1951 0.0013
4521 Hypothetical protein BC_2969 0.0013
4540 Hypothetical protein TM_1070 0.0013
4555 Hypothetical protein MT1739 0.0013
4569 Hypothetical protein mshD 0.0013
4578 Hypothetical protein PA3270 0.0013
4747 Hypothetical protein PA3967 0.0013
5177 Hypothetical protein TM_0096 0.0013
5194 Hypothetical protein PA1204 0.0013
5240 Hypothetical protein Rv2991 0.0013
5370 Hypothetical protein TM_1158 0.0013
5710 Hypothetical protein Tb927.5.1360 0.0013
4990 PpcA ppcA 0.0013
4385 Cytochrome c' Not Available 0.0013
4967 Cytochrome c' cycA 0.0013
5038 Cytochrome c' Not Available 0.0013
5223 Cytochrome c' cycP 0.0013
3570 Cytochrome P450 152A1 cypC 0.0013
4289 Cytochrome P450 TT_P0059 0.0013
6262 Cytochrome P450 staP 0.0013
4920 Peroxidase/catalase katG 0.0013
4948 Cytochrome c-553 Not Available 0.0013
4992 Cytochrome c peroxidase Not Available 0.0013
4923 Cytochrome c3 DvMF_2499 0.0013
4945 Cytochrome c3 Not Available 0.0013
4949 Cytochrome c3 DVU_3171 0.0013
4968 Cytochrome c3 cytc3 0.0013
4997 Cytochrome c3 SO_2727 0.0013
5219 Cytochrome c3 cyd 0.0013
4902 Nine-heme cytochrome c Ddes_2038 0.0013
2119 Cytochrome b5 CYB5A 0.0013
4813 Heme oxygenase hmuO 0.0013
5769 Heme oxygenase Not Available 0.0013
4988 Sulfite oxidase, mitochondrial SUOX 0.0013
3189 High-molecular-weight cytochrome c hmcA 0.0013
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0013
3375 Acidic cytochrome c3 Not Available 0.0013
2915 Sensor protein fixL fixL 0.0013
4944 Sensor protein fixL fixL 0.0013
4924 Cytochrome P450 2C8 CYP2C8 0.0012
4386 Hemoglobin-like protein HbN glbN 0.0012
3670 Soluble cytochrome b562 precursor cybC 0.0012
3291 Cytochrome c-552 cycA 0.0012
4927 Cytochrome c-552 nrfA 0.0012
4938 Cytochrome c-552 cycA 0.0012
4953 Cytochrome c-552 nrfA 0.0012
5217 Cytochrome c-552 cycM 0.0012
3102 Flavohemoprotein hmp 0.0012
4969 Flavohemoprotein hmp 0.0012
3411 Cytochrome P450 121 cyp121 0.0012
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0011
3127 Nitrite reductase nirS 0.0011
3284 Nitrite reductase nirS 0.0011
3221 Cytochrome c4 cc4 0.0011
2230 Catalase CAT 0.0011
3249 Catalase katA 0.0011
3625 Catalase katA 0.0011
4539 Catalase katA 0.0011
4941 Catalase katB 0.0011
871 Glucocorticoid receptor NR3C1 0.0011
4608 Putative cytochrome P450 SCO1207 0.0011
4963 Putative cytochrome P450 SCO2884 0.0011
6254 Putative cytochrome P450 SCO6998 0.0011
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0011
605 Fumarate reductase flavoprotein subunit frdA 0.001
2709 Fumarate reductase flavoprotein subunit SO_0970 0.001
3673 Fumarate reductase flavoprotein subunit fccA 0.001
4912 Fumarate reductase flavoprotein subunit ifcA 0.001
6549 Fumarate reductase flavoprotein subunit frdA 0.001
2972 6-deoxyerythronolide B hydroxylase eryF 0.001
1507 Cytochrome c CYCS 0.0009
6024 Cytochrome P450 1A1 CYP1A1 0.0009
518 Peroxidase/catalase T katG 0.0009
693 Hemoglobin subunit beta HBB 0.0009
6268 Hydroxyacid oxidase 1 HAO1 0.0009
6107 Cytochrome P450 3A7 CYP3A7 0.0009
810 Heme oxygenase 1 HMOX1 0.0009
3391 Heme oxygenase 1 pbsA1 0.0009
4118 Cytochrome P450 3A5 CYP3A5 0.0008
2298 Cytochrome P450-cam camC 0.0008
358 Cystathionine beta-synthase CBS 0.0008
275 Arachidonate 5-lipoxygenase ALOX5 0.0006
6106 Cytochrome P450 2C18 CYP2C18 0.0005
587 Serum albumin ALB 0.0004
↑