DT-Web

DB01972 - Guanosine-5'-Monophosphate


Identification
Name Guanosine-5'-Monophosphate
Accession Number DB01972 (EXPT00246)
Type small molecule
Description Guanosine 5'-monophosphate. A guanine nucleotide containing one phosphate group esterified to the sugar moiety and found widely in nature. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 363.2206
Groups experimental
Monoisotopic Weight 363.057998961
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Guanylate kinase
Name Guanylate kinase
Gene Name GUK1
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 0.7289
Response regulator pleD
Name Response regulator pleD
Gene Name pleD
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.8218
DNA polymerase
Name DNA polymerase
Gene Name 43
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 1.537
Disks large homolog 4
Name Disks large homolog 4
Gene Name DLG4
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score Not Available
GMP reductase 1
Name GMP reductase 1
Gene Name GMPR
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.8217
cGMP-specific 3',5'-cyclic phosphodiesterase
Name cGMP-specific 3',5'-cyclic phosphodiesterase
Gene Name PDE5A
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score Not Available
Histidine triad nucleotide-binding protein 1
Name Histidine triad nucleotide-binding protein 1
Gene Name HINT1
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 1.5688
Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase
Name Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase
Gene Name ATIC
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 1.2574
PyrR bifunctional protein [Includes: Pyrimidine operon regulatory protein; Uracil phosphoribosyltransferase
Name PyrR bifunctional protein [Includes: Pyrimidine operon regulatory protein; Uracil phosphoribosyltransferase
Gene Name pyrR
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 1.0488
Amidophosphoribosyltransferase
Name Amidophosphoribosyltransferase
Gene Name purF
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.0104
Protein-glutamine gamma-glutamyltransferase E
Name Protein-glutamine gamma-glutamyltransferase E
Gene Name TGM3
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.7247
Xanthine phosphoribosyltransferase
Name Xanthine phosphoribosyltransferase
Gene Name gpt
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 1.3058
Bifunctional adenosylcobalamin biosynthesis protein cobU
Name Bifunctional adenosylcobalamin biosynthesis protein cobU
Gene Name cobU
Pharmacological action unknown
Actions Not Available
References Not Available
DTHybrid score 0.7616
Amidophosphoribosyltransferase
Name Amidophosphoribosyltransferase
Gene Name purF
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.0104

Predictions


Id Partner name Gene Name Score
338 DNA polymerase UL30 1.537
379 DNA polymerase UL54 1.537
697 DNA polymerase ORF28 1.537
4104 DNA polymerase BALF5 1.537
3300 Xanthine phosphoribosyltransferase xpt 1.3058
4516 Guanylate kinase gmk 0.7289
3015 Pur operon repressor purR 0.4234
2865 Ribonuclease Not Available 0.3541
2837 Xanthosine phosphorylase xapA 0.3429
277 Purine nucleoside phosphorylase PNP 0.1889
2870 Purine nucleoside phosphorylase punA 0.1889
2945 Purine nucleoside phosphorylase punA 0.1889
4659 Purine nucleoside phosphorylase TM_1596 0.1889
4825 Purine nucleoside phosphorylase TTHA1435 0.1889
2521 Cell division protein ftsZ ftsZ 0.129
3301 Cell division protein ftsZ ftsZ 0.129
6750 ADP-ribosylation factor 6 ARF6 0.1268
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.1266
1673 GTP cyclohydrolase I GCH1 0.1126
3302 GTP cyclohydrolase I folE 0.1126
87 Hypoxanthine-guanine phosphoribosyltransferase HPRT1 0.1107
5360 High-affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE9A 0.0738
3575 Uracil phosphoribosyltransferase upp 0.0708
3600 Uracil phosphoribosyltransferase upp 0.0708
3529 Interferon-stimulated gene 20 kDa protein ISG20 0.0708
3056 Orotidine 5'-phosphate decarboxylase pyrF 0.0708
3564 Orotidine 5'-phosphate decarboxylase pyrF 0.0708
2344 Ribosomal small subunit pseudouridine synthase A rsuA 0.0617
3706 Ribosomal small subunit pseudouridine synthase A rsuA 0.0617
3257 Bifunctional polymyxin resistance protein arnA arnA 0.0615
4512 Cytochrome P450 3A4 CYP3A4 0.0613
2590 Galactose-1-phosphate uridylyltransferase galT 0.0568
2383 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase ispF 0.0545
2937 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase ispF 0.0545
4620 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase ispF 0.0545
6594 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase ispF 0.0545
6609 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase ispF 0.0545
6646 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase ispF 0.0545
2757 Inorganic pyrophosphatase ppa 0.0544
6238 Inorganic pyrophosphatase ppa 0.0544
6968 Inorganic pyrophosphatase PPA1 0.0544
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0529
2727 S-adenosylmethionine synthetase metK 0.0528
3067 Aquaporin Z aqpZ 0.0482
6320 Aquaporin Z aqpZ 0.0482
6039 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A PDE11A 0.0479
2755 Hypoxanthine-guanine-xanthine phosphoribosyltransferase LACZ 0.0473
2647 RNA-directed RNA polymerase P2 0.0473
6395 Myosin-14 MYH14 0.0469
5294 Nucleoside diphosphate kinase A NME1 0.0468
287 Beta-1,4-galactosyltransferase 1 B4GALT1 0.0463
2149 Angiogenin ANG 0.0459
3010 Regulatory protein blaR1 blaR1 0.0436
6385 H subunit of photosynthetic reaction center complex puhA 0.042
6388 Cytochrome c1 petC 0.0419
6387 Ubiquinol-cytochrome c reductase iron-sulfur subunit petA 0.0419
1227 Cytochrome b MT-CYB 0.0419
6386 Cytochrome b petB 0.0419
6937 Cytochrome b MT-CYB 0.0419
3023 DNA polymerase I, thermostable polA 0.0418
2434 NH(3)-dependent NAD(+) synthetase nadE 0.0412
2910 NH(3)-dependent NAD(+) synthetase nadE 0.0412
3217 NH(3)-dependent NAD(+) synthetase nadE 0.0412
4600 Malonamidase E2 Not Available 0.0412
2885 Carboxyethyl-arginine beta-lactam-synthase bls 0.0412
901 Glutathione S-transferase Mu 4 GSTM4 0.0401
2717 Folylpolyglutamate synthase fgs 0.0394
2428 Thiamine-phosphate pyrophosphorylase thiE 0.0369
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0365
1043 Trifunctional purine biosynthetic protein adenosine-3 [Includes: Phosphoribosylamine--glycine ligase GART 0.0356
4773 Deoxycytidine kinase DCK 0.0337
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0318
4118 Cytochrome P450 3A5 CYP3A5 0.0307
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0295
2207 Rhodopsin RHO 0.0275
24 Thymidylate synthase TMP1 0.0274
359 Thymidylate synthase TYMS 0.0274
2626 Thymidylate synthase thyA 0.0274
2729 Thymidylate synthase thyA 0.0274
5352 Thymidylate synthase THYA 0.0274
365 Dihydrofolate reductase DHFR 0.0272
2381 Dihydrofolate reductase DFR1 0.0272
2833 Dihydrofolate reductase Not Available 0.0272
2931 Dihydrofolate reductase folA 0.0272
3544 Dihydrofolate reductase folA 0.0272
3682 Dihydrofolate reductase folA 0.0272
6642 Dihydrofolate reductase folA 0.0272
6756 Dihydrofolate reductase dfrA 0.0272
851 5'-AMP-activated protein kinase subunit beta-2 PRKAB2 0.0256
388 AMP deaminase 1 AMPD1 0.0256
2358 cAMP-specific 3',5'-cyclic phosphodiesterase 4D PDE4D 0.0248
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0232
1596 Protein-glutamine gamma-glutamyltransferase 2 TGM2 0.0225
704 Long-chain-fatty-acid--CoA ligase 1 ACSL1 0.0214
297 Adenylate cyclase type 1 ADCY1 0.0213
821 Acetyl-coenzyme A synthetase 2-like, mitochondrial ACSS1 0.0213
386 Acetyl-coenzyme A synthetase, cytoplasmic ACSS2 0.0213
1178 Adenosine A2a receptor ADORA2A 0.0199
16 Adenosine A1 receptor ADORA1 0.0195
128 Adenine phosphoribosyltransferase APRT 0.0188
1291 cAMP response element-binding protein CREB1 0.0186
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0185
5304 UPF0166 protein TM_0021 TM_0021 0.0185
5287 Signaling protein Not Available 0.0185
5314 UPF0079 ATP-binding protein HI0065 HI_0065 0.0185
5288 Shikimate kinase aroK 0.0185
3199 Phosphopantetheine adenylyltransferase coaD 0.0185
3543 Phosphopantetheine adenylyltransferase coaD 0.0185
3567 Phosphopantetheine adenylyltransferase coaD 0.0185
5289 Phosphopantetheine adenylyltransferase coaD 0.0185
5293 Shikimate kinase 2 aroL 0.0185
5292 Putative partitioning protein TT_C1605 0.0185
4346 Polynucleotide kinase pseT 0.0185
5283 D-alanine--D-alanine ligase B ddlB 0.0185
5275 Multidrug resistance ABC transporter ATP-binding and permease protein lmrA 0.0185
2874 Nitrogenase iron protein 1 nifH1 0.0185
5281 Plasmid segregation protein parM parM 0.0185
5299 D-alanine--D-alanine ligase ddl 0.0185
6598 D-alanine--D-alanine ligase ddl 0.0185
5291 Glycogen synthase 1 glgA1 0.0185
5276 Chromosomal replication initiator protein dnaA dnaA 0.0185
5259 Transcriptional regulator ntrC1 0.0185
6699 Transcriptional regulator Cgl2612 0.0185
5270 ATP-dependent Clp protease ATP-binding subunit clpX clpX 0.0185
5266 Activator of hgdC 0.0185
4794 Phosphoenolpyruvate carboxykinase [ATP] pckA 0.0185
5305 Phosphoribosylaminoimidazole carboxylase ATPase subunit purK 0.0185
3777 ATP-dependent Clp protease ATP-binding subunit clpA clpA 0.0185
1549 Heat shock 70 kDa protein 1 HSPA1A 0.0185
5284 Large T antigen Not Available 0.0185
5315 Chaperone protein htpG htpG 0.0185
5285 Kinesin heavy chain KIF5B 0.0185
5264 DNA replication protein REP 0.0185
5290 ATP-dependent hsl protease ATP-binding subunit hslU hslU 0.0184
5638 ATP-dependent hsl protease ATP-binding subunit hslU hslU 0.0184
5277 Preprotein translocase subunit secA secA 0.0184
5308 Preprotein translocase secA 1 subunit secA1 0.0184
3957 Adenosine deaminase ADA 0.0183
1830 5'-nucleotidase NT5E 0.0183
281 5'-AMP-activated protein kinase subunit beta-1 PRKAB1 0.0182
2164 Multidrug resistance-associated protein 4 ABCC4 0.0182
6136 Multidrug resistance-associated protein 5 ABCC5 0.0177
6216 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A PDE8A 0.0177
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.0175
6021 Adenosine kinase ADK 0.0172
2256 cGMP-inhibited 3',5'-cyclic phosphodiesterase B PDE3B 0.0168
4198 Fructose-1,6-bisphosphatase 1 FBP1 0.0166
4366 Riboflavin kinase/FMN adenylyltransferase TM_0857 0.0163
3470 Hypothetical protein MG245 homolog MPN_348 0.0161
2270 Dephospho-CoA kinase coaE 0.0161
2284 Adenylate kinase adk 0.0161
2296 Adenylate kinase adk 0.0161
2311 Adenylate kinase adk 0.0161
2312 Adenylate kinase Not Available 0.0161
2751 Holliday junction ATP-dependent DNA helicase ruvB ruvB 0.0161
4755 Holliday junction ATP-dependent DNA helicase ruvB ruvB 0.0161
5295 2-keto-3-deoxy-gluconate kinase TT_P0036 0.0161
4837 Cag-alfa cag-alfa 0.0161
3390 Aminoglycoside 3'-phosphotransferase aphA 0.0161
6029 Aminoglycoside 3'-phosphotransferase aphA1 0.0161
5646 Galactokinase GALK1 0.0161
4839 DNA polymerase III subunit tau dnaX 0.0161
4774 NTPase P4 Not Available 0.0161
3175 Glutamate--cysteine ligase gshA 0.0161
6277 Heat shock cognate 71 kDa protein HSPA8 0.0161
5302 TrwB trwB 0.0161
5189 Trimethylamine dehydrogenase tmd 0.0161
5265 FtsH ftsH 0.0161
3426 Glutamine synthetase glnA 0.0161
3987 Glutamine synthetase GLUL 0.0161
4838 PMS1 protein homolog 2 PMS2 0.0161
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.016
779 High-affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A PDE7A 0.0156
340 Apoptotic protease-activating factor 1 APAF1 0.0155
10 Glycogen phosphorylase, liver form PYGL 0.015
2697 Uridine-cytidine kinase 2 UCK2 0.0149
2390 Nonsecretory ribonuclease RNASE2 0.0148
2683 Mono-ADP-ribosyltransferase C3 C3 0.0148
2922 Glycerol kinase glpK 0.0148
5271 Focal adhesion kinase 1 PTK2 0.0148
5312 Kinesin-like protein KIF1A KIF1A 0.0148
5300 Antigen peptide transporter 1 TAP1 0.0145
2282 Protein recA recA 0.0145
2315 Protein recA recA 0.0145
2332 Protein recA recA 0.0145
5263 Protein recA recA 0.0145
408 Riboflavin kinase RFK 0.0143
3669 Ribokinase rbsK 0.014
2371 Pantothenate kinase coaA 0.014
2892 Acetylglutamate kinase argB 0.014
3550 Acetylglutamate kinase argB 0.014
2950 Inositol-trisphosphate 3-kinase A ITPKA 0.014
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.014
825 Arsenical pump-driving ATPase ASNA1 0.014
3435 Arsenical pump-driving ATPase arsA 0.014
6857 [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 2, mitochondrial PDK2 0.014
2615 Chemotaxis protein cheA cheA 0.014
1881 Hexokinase-1 HK1 0.014
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.014
6390 Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 ATP2A1 0.0134
6832 Serine/threonine-protein kinase SRPK2 SRPK2 0.0134
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0133
788 Creatine kinase M-type CKM 0.0133
5618 ADP-ribosylation factor 4 ARF4 0.0131
1882 Ras-related C3 botulinum toxin substrate 1 RAC1 0.0131
2170 Transforming protein RhoA RHOA 0.0131
5624 GTPase rab6 0.0131
3366 GTP-binding protein engA der 0.0131
3197 GDP-mannose mannosyl hydrolase nudD 0.0131
5628 Probable GTPase engC rsgA 0.0131
5630 ADP-ribosylation factor-like protein 5A ARL5A 0.0131
5627 GDP-mannose 4,6-dehydratase gca 0.0131
2334 Dethiobiotin synthetase bioD 0.0129
6555 Dethiobiotin synthetase bioD 0.0129
2817 Phosphoribosylglycinamide formyltransferase 2 purT 0.0129
453 S-adenosylmethionine synthetase isoform type-1 MAT1A 0.0126
61 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0125
2644 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0125
2710 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0125
3986 Protein-glutamine gamma-glutamyltransferase 6 TGM6 0.0124
6 Coagulation factor XIII A chain F13A1 0.0124
3983 Protein-glutamine gamma-glutamyltransferase 5 TGM5 0.0123
3992 Protein-glutamine gamma-glutamyltransferase Z TGM7 0.0123
3990 Protein-glutamine gamma-glutamyltransferase 4 TGM4 0.0123
3988 Protein-glutamine gamma-glutamyltransferase K TGM1 0.0123
1008 CTP synthase 1 CTPS 0.0122
3985 Glucosamine--fructose-6-phosphate aminotransferase [isomerizing] 2 GFPT2 0.0122
3989 Glutaminyl-tRNA synthetase QARS 0.0122
2511 MAP kinase-activated protein kinase 2 MAPKAPK2 0.0122
3920 Methylenetetrahydrofolate reductase intermediate form MTHFR 0.0122
3763 5,10-methylenetetrahydrofolate reductase metF 0.0122
3918 5,10-methylenetetrahydrofolate reductase MTHFR 0.0122
5094 5,10-methylenetetrahydrofolate reductase metF 0.0122
59 AMT protein AMT 0.0122
3919 Methionyl-tRNA formyltransferase, mitochondrial MTFMT 0.0122
1202 10-formyltetrahydrofolate dehydrogenase ALDH1L1 0.0122
48 Pyridoxal kinase PDXK 0.0121
702 UMP-CMP kinase CMPK1 0.0121
3917 Methylenetetrahydrofolate reductase MTHFR 0.0119
2317 UDP-N-acetylmuramoylalanine--D-glutamate ligase murD 0.0119
2091 Endoplasmin HSP90B1 0.0119
201 Glutamate dehydrogenase 1, mitochondrial GLUD1 0.0118
2251 Thymidylate kinase tmk 0.0118
2254 Thymidylate kinase DTYMK 0.0118
3522 Thymidylate kinase tmk 0.0118
207 Glutathione synthetase GSS 0.0116
5269 Glutathione synthetase gshB 0.0116
3261 Signal recognition particle protein ffh 0.0115
3115 Ras-related protein Rab-9 RAB9A 0.0114
1422 Serine/threonine-protein kinase 6 AURKA 0.0114
3170 Elongation factor Tu-B tufB 0.0114
3396 Elongation factor Tu tufA 0.0114
5621 Elongation factor Tu tuf 0.0114
3270 Elongation factor G fusA 0.0114
3354 Ras-related protein Rap-2a RAP2A 0.0114
3335 Probable GTP-binding protein engB engB 0.0114
5619 GDP-mannose 4,6 dehydratase GMDS 0.0114
3107 Putative GTP pyrophosphokinase relA 0.0114
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0113
3379 Kinesin-like protein KIF11 KIF11 0.0112
3456 Heat shock protein HSP 90-beta HSP90AB1 0.011
3822 Actin, alpha skeletal muscle ACTA1 0.0109
3971 CAD protein [Includes: Glutamine-dependent carbamoyl-phosphate synthase CAD 0.0108
5682 Ribonuclease pancreatic RNASE1 0.0108
504 Mast/stem cell growth factor receptor KIT 0.0107
6556 Elongation factor Tu GTP-binding domain-containing protein 1 EFTUD1 0.0107
13 Aminomethyltransferase, mitochondrial AMT 0.0106
301 Kynurenine--oxoglutarate transaminase 1 CCBL1 0.0106
509 Thymidine kinase TK 0.0105
570 Thymidine kinase TK 0.0105
2559 Thymidine kinase TK 0.0105
3430 Thymidine kinase tdk 0.0105
3518 Thymidine kinase TK 0.0105
5301 Thymidine kinase tdk 0.0105
5771 Thymidine kinase ORF36 0.0105
7009 Thymidine kinase ORF36 0.0105
6447 Guanine nucleotide-binding protein G(t) subunit alpha-1 GNAT1 0.0105
413 Amidophosphoribosyltransferase PPAT 0.0104
296 Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial MTHFD2 0.0103
3982 Phosphoribosylformylglycinamidine synthase PFAS 0.0103
5261 Phosphoribosylformylglycinamidine synthase purL 0.0103
5 Glutaminase liver isoform, mitochondrial GLS2 0.0103
917 Glutaminase kidney isoform, mitochondrial GLS 0.0103
355 GMP synthase [glutamine-hydrolyzing] GMPS 0.0103
4353 GMP synthase [glutamine-hydrolyzing] guaA 0.0103
3991 Glutamine-dependent NAD(+) synthetase NADSYN1 0.0103
3984 Probable glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial PET112L 0.0103
263 Neutral amino acid transporter B(0) SLC1A5 0.0102
1721 Glycogen synthase kinase-3 beta GSK3B 0.01
679 C-1-tetrahydrofolate synthase, cytoplasmic MTHFD1 0.01
6790 Elongation factor 2 EEF2 0.01
6148 Multidrug resistance-associated protein 7 ABCC10 0.0099
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0096
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0096
1758 GTPase HRas HRAS 0.0095
4200 Cytochrome P450 1A2 CYP1A2 0.0095
914 Formimidoyltransferase-cyclodeaminase FTCD 0.0094
314 System N amino acid transporter 1 SLC38A3 0.0094
866 Large neutral amino acids transporter small subunit 2 SLC7A8 0.0092
1588 Multidrug resistance protein 1 ABCB1 0.009
6316 ADP-ribosylation factor 1 ARF1 0.0089
3884 SHMT2 protein SHMT2 0.0089
3901 SHMT2 protein SHMT2 0.0089
3885 Hypothetical protein DKFZp686P09201 DKFZp686P09201 0.0089
3879 Serine hydroxymethyltransferase 2 Not Available 0.0089
321 Serine hydroxymethyltransferase, mitochondrial SHMT2 0.0089
242 Asparagine synthetase [glutamine-hydrolyzing] ASNS 0.0088
367 Serine hydroxymethyltransferase, cytosolic SHMT1 0.0087
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0085
3978 Adenylosuccinate synthetase isozyme 1 ADSSL1 0.0085
2632 Adenylosuccinate synthetase purA 0.0083
3323 Adenylosuccinate synthetase purA 0.0083
3975 Adenylosuccinate synthetase ADSS 0.0083
4598 Adenylosuccinate synthetase Adss 0.0083
6817 Adenylosuccinate synthetase purA 0.0083
809 Methionine synthase MTR 0.0083
2935 Methionine synthase metH 0.0083
5626 Nucleoside diphosphate kinase B NME2 0.008
5818 Folate receptor alpha FOLR1 0.0079
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0077
6024 Cytochrome P450 1A1 CYP1A1 0.0073
6143 Solute carrier family 22 member 7 SLC22A7 0.0072
268 Adenosine A2b receptor ADORA2B 0.0071
6013 Cytochrome P450 2E1 CYP2E1 0.0069
293 Gamma-glutamyl hydrolase GGH 0.0068
6151 Monocarboxylate transporter 10 SLC16A10 0.0064
1650 Heme carrier protein 1 SLC46A1 0.0061
4122 Histone deacetylase 2 HDAC2 0.0061
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0061
4757 Cytochrome P450 2C9 CYP2C9 0.0059
4119 Cytochrome P450 2D6 CYP2D6 0.0058
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0053
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0053
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0046
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0045
6020 Aldehyde oxidase AOX1 0.0043
738 Monocarboxylate transporter 1 SLC16A1 0.0042
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.004
1898 Cytochrome P450 1B1 CYP1B1 0.0039
6107 Cytochrome P450 3A7 CYP3A7 0.0038
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0038
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0037
6016 Cytochrome P450 2C19 CYP2C19 0.0035
1024 Solute carrier family 22 member 11 SLC22A11 0.0034
862 Multidrug resistance-associated protein 1 ABCC1 0.0032
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0032
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0032
6142 Solute carrier family 22 member 8 SLC22A8 0.003
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.003
4924 Cytochrome P450 2C8 CYP2C8 0.0028
5590 N utilization substance protein B homolog nusB 0.0028
5598 Glycerol uptake operon antiterminator-related protein TM_1436 0.0028
5577 N5-carboxyaminoimidazole ribonucleotide mutase purE 0.0028
5591 Complement component C8 gamma chain C8G 0.0028
3792 KHG/KDPG aldolase [Includes: 4-hydroxy-2-oxoglutarate aldolase eda 0.0028
5582 Regulator of transcription; stringent starvation protein A sspA 0.0028
5587 Iron(III)-binding periplasmic protein fbpA 0.0028
2838 Ribose-5-phosphate isomerase A rpiA 0.0028
2952 Ribose-5-phosphate isomerase A rpiA 0.0028
5595 Ribose-5-phosphate isomerase A rpiA 0.0028
4238 50S ribosomal protein L4 rplD 0.0028
5578 50S ribosomal protein L4 rplD 0.0028
6173 50S ribosomal protein L4 rplD 0.0028
6219 50S ribosomal protein L4 rplD 0.0028
4695 UPF0124 protein yfiH yfiH 0.0028
5060 Intron-associated endonuclease 1 ITEVIR 0.0028
5593 Transferase Not Available 0.0028
5581 Beta-fructosidase bfrA 0.0028
5588 Cell division protein FtsY TM_0570 0.0028
5592 Ribonucleoside-diphosphate reductase subunit beta nrdF 0.0028
2300 Lysozyme E 0.0028
3633 Lysozyme R 0.0028
5597 Lysozyme 17 0.0028
5583 RNA 3'-terminal phosphate cyclase rtcA 0.0028
5600 Pyruvate decarboxylase pdc 0.0028
5586 Pleckstrin homology domain-containing family A member 1 PLEKHA1 0.0028
4375 Glutamine synthetase 1 glnA1 0.0028
5575 Short tail fiber protein 12 0.0028
5574 Invasin YPTB1668 0.0028
5580 Hexon protein PII 0.0028
587 Serum albumin ALB 0.0028
1729 Solute carrier family 22 member 6 SLC22A6 0.0028
3087 Nicotinate-nucleotide adenylyltransferase nadD 0.0027
4469 Nicotinate-nucleotide adenylyltransferase nadD 0.0027
4992 Cytochrome c peroxidase Not Available 0.0027
3132 Tryptophan synthase alpha chain trpA 0.0025
6568 Tryptophan synthase alpha chain trpA 0.0025
3085 Molybdopterin-guanine dinucleotide biosynthesis protein A mobA 0.0024
3729 Citrate synthase gltA 0.0024
4575 Citrate synthase cit 0.0024
4580 Citrate synthase gltA 0.0024
5328 Prostaglandin F synthase Tb11.02.2310 0.0024
5006 RNASE4 protein RNASE4 0.0024
2555 Pol polyprotein pol 0.0024
3242 Pol polyprotein gag-pol 0.0024
3471 Pol polyprotein gag-pro-pol 0.0024
5256 Pol polyprotein pol 0.0024
6469 Pol polyprotein gag-pol 0.0024
6565 Pol polyprotein Not Available 0.0024
4533 Glyoxalase family protein BC_1747 0.0024
5599 3-carboxy-cis,cis-muconate cycloisomerase pcaB 0.0024
1467 Tumor necrosis factor ligand superfamily member 13B TNFSF13B 0.0024
4373 Medium-chain-fatty-acid--CoA ligase Not Available 0.0022
2603 Beta-lactamase II blm 0.0022
3583 6-phosphogluconolactonase pgl 0.0022
857 Malate dehydrogenase, mitochondrial MDH2 0.0021
2869 1-deoxy-D-xylulose 5-phosphate reductoisomerase dxr 0.0021
3486 Fumarate hydratase class II fumC 0.0021
2286 Isocitrate dehydrogenase [NADP] icd 0.0021
2302 Isocitrate dehydrogenase [NADP] icd 0.0021
2771 Isocitrate dehydrogenase [NADP] icd 0.0021
2942 Sialidase nanH 0.0021
3546 Sialidase nedA 0.0021
1123 Eosinophil cationic protein RNASE3 0.0021
941 Betaine--homocysteine S-methyltransferase 1 BHMT 0.002
332 Beta-lactamase blaZ 0.002
2478 Beta-lactamase ampC 0.002
2613 Beta-lactamase ampC 0.002
2635 Beta-lactamase ampC 0.002
2700 Beta-lactamase penP 0.002
5445 Beta-lactamase blaB 0.002
6019 Beta-lactamase SHV-7 0.002
6701 Beta-lactamase cphA 0.002
2452 Tryptophanyl-tRNA synthetase trpS 0.002
2805 Heparan sulfate glucosamine 3-O-sulfotransferase 3A1 HS3ST3A1 0.002
2936 Oxygen-insensitive NAD(P)H nitroreductase nfnB 0.002
5184 Oxygen-insensitive NAD(P)H nitroreductase nfnB 0.002
411 Glycine N-methyltransferase GNMT 0.0019
3478 Glucose-1-phosphate thymidylyltransferase rmlA 0.0019
4277 Glucose-1-phosphate thymidylyltransferase rmlA 0.0019
5579 Carboxypeptidase B CPB1 0.0018
3384 Macrophage migration inhibitory factor MIF 0.0018
822 Aldose reductase AKR1B1 0.0014
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0013
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0012
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