DT-Web

DB02703 - Fusidic Acid


Identification
Name Fusidic Acid
Accession Number DB02703 (EXPT01507)
Type small molecule
Description An antibiotic isolated from the fermentation broth of Fusidium coccineum. (From Merck Index, 11th ed) It acts by inhibiting translocation during protein synthesis.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 516.7092
Groups approved
Monoisotopic Weight 516.345089268
Pharmacology
Indication For the treatment of bacterial infections.
Mechanism of action Fusidic acid works by interfering with bacterial protein synthesis, specifically by preventing the translocation of the elongation factor G (EF-G) from the ribosome. It also can inhibit chloramphenicol acetyltransferase enzymes.
Absorption Sodium fusidic acid tablets have a 91% oral bioavailability. Absorption of the film-coated tablets is complete when compared to a solution, however oral absorption is variable. Oral fusidic acid hemihydrate (suspension) achieved a 22.5% bioavailability in pediatric patients following a 20 milligram/kilogram dose.
Protein binding 97 to 99%
Biotransformation Metabolites include dicarboxylic ester/acid, 3-keto fusidic acid, hydroxy fusidic acid, glucuronide fusidic acid and a glycol metabolite.
Route of elimination Not Available
Toxicity Not Available
Affected organisms
  • Enteric bacteria and other eubacteria
Interactions
Drug Interactions
Drug Mechanism of interaction
Amprenavir The protease inhibitor, amprenavir, may increase the effect and toxicity of fusidic acid.
Atorvastatin Increased risk of myopathy/rhabdomyolysis
Fosamprenavir The protease inhibitor, fosamprenavir, may increase the effect and toxicity of fusidic acid.
Indinavir Indinavir may increase the effect and toxicity of fusidic acid.
Nelfinavir The protease inhibitor, nelfinavir, may increase the effect and toxicity of fusidic acid.
Penicillin V Fusidic acid may diminish the therapeutic effect of penicillins. To management this interaction, penicillin should be administered 2 hours before fusidic acid.
Ritonavir The protease inhibitor, ritonavir, may increase the effect and toxicity of fusidic acid.
Saquinavir The protease inhibitor, saquinavir, may increase the effect and toxicity of fusidic acid.
Simvastatin Increased risk of myopathy/rhabdomyolysis
Ticarcillin Fusidic acid may reduce the effect of Ticarcillin by inhibiting bacterial growth. Ticarcillin exerts its effects on actively growing bacteria. To achieve synergism, Ticarcillin should be administered at least 2 hours prior to using Fusidic acid.
Tipranavir Concomitant therapy of Tipranavir with Fusidic acid may result in increased serum concentrations of both agents. Consider alternate therapy or monitor for increased serum concentrations and toxocity of both agents.
Food Interactions
  • Take with food to reduce irritation.

Targets


Elongation factor G
Name Elongation factor G
Gene Name fusA
Pharmacological action yes
Actions inhibitor
References
  • Lannergard J, Norstrom T, Hughes D: Genetic determinants of resistance to fusidic acid among clinical bacteremia isolates of Staphylococcus aureus. Antimicrob Agents Chemother. 2009 May;53(5):2059-65. Epub 2009 Mar 16. - Pubmed
  • Chen Y, Koripella RK, Sanyal S, Selmer M: Staphylococcus aureus elongation factor G--structure and analysis of a target for fusidic acid. FEBS J. 2010 Sep;277(18):3789-803. - Pubmed
  • Gao YG, Selmer M, Dunham CM, Weixlbaumer A, Kelley AC, Ramakrishnan V: The structure of the ribosome with elongation factor G trapped in the posttranslocational state. Science. 2009 Oct 30;326(5953):694-9. - Pubmed
DTHybrid score 0.6802
Chloramphenicol acetyltransferase
Name Chloramphenicol acetyltransferase
Gene Name cat
Pharmacological action unknown
Actions inhibitor
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Murray IA, Cann PA, Day PJ, Derrick JP, Sutcliffe MJ, Shaw WV, Leslie AG: Steroid recognition by chloramphenicol acetyltransferase: engineering and structural analysis of a high affinity fusidic acid binding site. J Mol Biol. 1995 Dec 15;254(5):993-1005. - Pubmed
  • Bennett AD, Shaw WV: Resistance to fusidic acid in Escherichia coli mediated by the type I variant of chloramphenicol acetyltransferase. A plasmid-encoded mechanism involving antibiotic binding. Biochem J. 1983 Oct 1;215(1):29-38. - Pubmed
  • Day PJ, Murray IA, Shaw WV: Properties of hybrid active sites in oligomeric proteins: kinetic and ligand binding studies with chloramphenicol acetyltransferase trimers. Biochemistry. 1995 May 16;34(19):6416-22. - Pubmed
DTHybrid score 0.0485
Chloramphenicol acetyltransferase 3
Name Chloramphenicol acetyltransferase 3
Gene Name cat3
Pharmacological action unknown
Actions inhibitor
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Murray IA, Cann PA, Day PJ, Derrick JP, Sutcliffe MJ, Shaw WV, Leslie AG: Steroid recognition by chloramphenicol acetyltransferase: engineering and structural analysis of a high affinity fusidic acid binding site. J Mol Biol. 1995 Dec 15;254(5):993-1005. - Pubmed
  • Bennett AD, Shaw WV: Resistance to fusidic acid in Escherichia coli mediated by the type I variant of chloramphenicol acetyltransferase. A plasmid-encoded mechanism involving antibiotic binding. Biochem J. 1983 Oct 1;215(1):29-38. - Pubmed
  • Day PJ, Murray IA, Shaw WV: Properties of hybrid active sites in oligomeric proteins: kinetic and ligand binding studies with chloramphenicol acetyltransferase trimers. Biochemistry. 1995 May 16;34(19):6416-22. - Pubmed
DTHybrid score 0.6244

Transporters


Bile salt export pump
Name Bile salt export pump
Gene Name ABCB11
Actions inhibitor
References
  • Bode KA, Donner MG, Leier I, Keppler D: Inhibition of transport across the hepatocyte canalicular membrane by the antibiotic fusidate. Biochem Pharmacol. 2002 Jul 1;64(1):151-8. - Pubmed
DTHybrid score 0.3877
Canalicular multispecific organic anion transporter 1
Name Canalicular multispecific organic anion transporter 1
Gene Name ABCC2
Actions inhibitor
References
  • Bode KA, Donner MG, Leier I, Keppler D: Inhibition of transport across the hepatocyte canalicular membrane by the antibiotic fusidate. Biochem Pharmacol. 2002 Jul 1;64(1):151-8. - Pubmed
DTHybrid score 0.3853

Predictions


Id Partner name Gene Name Score
1588 Multidrug resistance protein 1 ABCB1 0.0751
4512 Cytochrome P450 3A4 CYP3A4 0.0707
1196 Complement decay-accelerating factor CD55 0.0649
4118 Cytochrome P450 3A5 CYP3A5 0.0598
2810 Dr hemagglutinin structural subunit draA 0.0567
4757 Cytochrome P450 2C9 CYP2C9 0.0553
4924 Cytochrome P450 2C8 CYP2C8 0.0546
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0545
862 Multidrug resistance-associated protein 1 ABCC1 0.0516
6107 Cytochrome P450 3A7 CYP3A7 0.0505
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0491
2417 Chloramphenicol acetyltransferase cat 0.0485
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0483
1729 Solute carrier family 22 member 6 SLC22A6 0.0467
6141 Sodium/bile acid cotransporter SLC10A1 0.0431
6016 Cytochrome P450 2C19 CYP2C19 0.043
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0394
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0369
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0353
5630 ADP-ribosylation factor-like protein 5A ARL5A 0.0297
5618 ADP-ribosylation factor 4 ARF4 0.0297
2170 Transforming protein RhoA RHOA 0.0297
3197 GDP-mannose mannosyl hydrolase nudD 0.0297
1882 Ras-related C3 botulinum toxin substrate 1 RAC1 0.0296
5624 GTPase rab6 0.0296
5628 Probable GTPase engC rsgA 0.0296
5627 GDP-mannose 4,6-dehydratase gca 0.0296
3366 GTP-binding protein engA der 0.0296
2164 Multidrug resistance-associated protein 4 ABCC4 0.0291
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0281
3354 Ras-related protein Rap-2a RAP2A 0.0258
3335 Probable GTP-binding protein engB engB 0.0258
3170 Elongation factor Tu-B tufB 0.0258
5619 GDP-mannose 4,6 dehydratase GMDS 0.0258
3396 Elongation factor Tu tufA 0.0258
5621 Elongation factor Tu tuf 0.0258
3261 Signal recognition particle protein ffh 0.0258
3115 Ras-related protein Rab-9 RAB9A 0.0258
3107 Putative GTP pyrophosphokinase relA 0.0258
6148 Multidrug resistance-associated protein 7 ABCC10 0.0241
6750 ADP-ribosylation factor 6 ARF6 0.0238
2521 Cell division protein ftsZ ftsZ 0.0238
3301 Cell division protein ftsZ ftsZ 0.0238
6447 Guanine nucleotide-binding protein G(t) subunit alpha-1 GNAT1 0.0238
6556 Elongation factor Tu GTP-binding domain-containing protein 1 EFTUD1 0.0238
4200 Cytochrome P450 1A2 CYP1A2 0.0227
6790 Elongation factor 2 EEF2 0.0225
4119 Cytochrome P450 2D6 CYP2D6 0.022
5626 Nucleoside diphosphate kinase B NME2 0.0215
1758 GTPase HRas HRAS 0.0215
6144 Solute carrier family 22 member 2 SLC22A2 0.0214
6030 Cytochrome P450 2B6 CYP2B6 0.021
1596 Protein-glutamine gamma-glutamyltransferase 2 TGM2 0.0206
6142 Solute carrier family 22 member 8 SLC22A8 0.0202
6316 ADP-ribosylation factor 1 ARF1 0.0201
5294 Nucleoside diphosphate kinase A NME1 0.0198
2339 Protein-glutamine gamma-glutamyltransferase E TGM3 0.0197
6024 Cytochrome P450 1A1 CYP1A1 0.0195
6145 Solute carrier family 22 member 1 SLC22A1 0.0194
1898 Cytochrome P450 1B1 CYP1B1 0.019
3978 Adenylosuccinate synthetase isozyme 1 ADSSL1 0.0189
2632 Adenylosuccinate synthetase purA 0.0187
3323 Adenylosuccinate synthetase purA 0.0187
3975 Adenylosuccinate synthetase ADSS 0.0187
4598 Adenylosuccinate synthetase Adss 0.0187
6817 Adenylosuccinate synthetase purA 0.0187
6013 Cytochrome P450 2E1 CYP2E1 0.0176
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0173
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0163
70 Type-1 angiotensin II receptor AGTR1 0.0158
683 Potassium transporter GK0582 0.0156
6137 Multidrug resistance-associated protein 6 ABCC6 0.0155
118 Organic cation/carnitine transporter 2 SLC22A5 0.0154
13 Aminomethyltransferase, mitochondrial AMT 0.0154
3671 7-alpha-hydroxysteroid dehydrogenase hdhA 0.0146
136 Estrogen receptor ESR1 0.0145
817 DNA topoisomerase 2-alpha TOP2A 0.0142
1024 Solute carrier family 22 member 11 SLC22A11 0.014
587 Serum albumin ALB 0.0133
6143 Solute carrier family 22 member 7 SLC22A7 0.0126
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0122
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0122
6339 Ig kappa chain V-II region RPMI 6410 Not Available 0.0115
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0114
477 DNA topoisomerase 4 subunit A parC 0.0113
886 DNA topoisomerase 4 subunit A parC 0.0113
6226 DNA topoisomerase 4 subunit A parC 0.0113
49 Endothelin B receptor EDNRB 0.0113
404 DNA gyrase subunit A gyrA 0.0111
6224 DNA gyrase subunit A gyrA 0.0111
2443 Azurin azu 0.0108
578 Endothelin-1 receptor EDNRA 0.0106
887 DNA gyrase subunit B gyrB 0.0105
4150 DNA gyrase subunit B gyrB 0.0105
6225 DNA gyrase subunit B gyrB 0.0105
5718 Cytochrome P450 2A6 CYP2A6 0.0102
161 Tubulin beta chain TUBB 0.0099
312 Tubulin beta chain TUB2 0.0099
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0099
686 Aldo-keto reductase family 1 member C2 AKR1C2 0.0096
6147 Solute carrier family 22 member 3 SLC22A3 0.0096
131 Synaptic vesicular amine transporter SLC18A2 0.0088
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0086
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0086
1435 Synaptic vesicle glycoprotein 2A SV2A 0.0084
3811 Cytochrome P450 19A1 CYP19A1 0.0083
738 Monocarboxylate transporter 1 SLC16A1 0.0083
850 Vasopressin V1b receptor AVPR1B 0.0081
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0081
614 Progesterone receptor PGR 0.008
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0079
833 Organic cation/carnitine transporter 1 SLC22A4 0.0077
1629 Transcription factor AP-1 JUN 0.0076
468 Cytochrome P450 4A11 CYP4A11 0.0075
33 Cystine/glutamate transporter SLC7A11 0.0075
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0074
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0072
3947 Xanthine dehydrogenase/oxidase XDH 0.0072
6167 Organic solute transporter subunit beta OSTB 0.0072
6166 Organic solute transporter subunit alpha OSTA 0.0071
185 Vasopressin V1a receptor AVPR1A 0.0071
6211 Tubulin epsilon chain TUBE1 0.007
6210 Tubulin delta chain TUBD1 0.007
6212 Tubulin gamma-1 chain TUBG1 0.007
322 Vasopressin V2 receptor AVPR2 0.007
4604 Liver carboxylesterase 1 CES1 0.0066
6136 Multidrug resistance-associated protein 5 ABCC5 0.0065
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0063
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0063
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0061
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0061
275 Arachidonate 5-lipoxygenase ALOX5 0.0061
5923 Microtubule-associated protein tau MAPT 0.006
5924 Microtubule-associated protein 4 MAP4 0.006
908 Glutathione S-transferase theta-1 GSTT1 0.006
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0059
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0059
4120 NADPH--cytochrome P450 reductase POR 0.0058
3587 Gastrotropin FABP6 0.0057
2539 Tubulin alpha-1 chain TUBA4A 0.0056
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0056
1852 Microtubule-associated protein 2 MAP2 0.0056
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0056
4192 DNA topoisomerase 2-beta TOP2B 0.0055
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0055
24 Thymidylate synthase TMP1 0.0055
359 Thymidylate synthase TYMS 0.0055
2626 Thymidylate synthase thyA 0.0055
2729 Thymidylate synthase thyA 0.0055
5352 Thymidylate synthase THYA 0.0055
165 FL cytokine receptor FLT3 0.0054
20 Prostaglandin G/H synthase 1 PTGS1 0.0053
273 Apoptosis regulator Bcl-2 BCL2 0.0053
2449 Tubulin alpha-3 chain TUBA1A 0.005
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0049
29 Tubulin beta-1 chain TUBB1 0.0048
737 Mineralocorticoid receptor NR3C2 0.0048
904 Glutathione S-transferase P GSTP1 0.0047
6163 Copper-transporting ATPase 2 ATP7B 0.0046
6165 Copper-transporting ATPase 1 ATP7A 0.0046
6031 Cytochrome P450 3A43 CYP3A43 0.0046
504 Mast/stem cell growth factor receptor KIT 0.0045
380 Cytochrome P450 17A1 CYP17A1 0.0045
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0045
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0044
6146 High affinity copper uptake protein 1 SLC31A1 0.0044
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0043
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0042
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0042
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0042
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0042
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0042
407 Vascular endothelial growth factor receptor 2 KDR 0.0042
896 Glutathione S-transferase Mu 1 GSTM1 0.0042
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0041
6106 Cytochrome P450 2C18 CYP2C18 0.0041
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0041
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0041
731 HIV-1 protease HIV-1 protease 0.0041
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.004
3809 Estrogen-related receptor gamma ESRRG 0.004
7 Nitric oxide synthase, inducible NOS2 0.0038
2232 Interleukin-5 IL5 0.0037
1593 Mucin-2 MUC2 0.0037
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0036
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0036
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0036
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0036
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0035
751 Potassium channel subfamily K member 6 KCNK6 0.0035
461 Glycine receptor subunit alpha-3 GLRA3 0.0035
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0035
2216 Fibroblast growth factor receptor 4 FGFR4 0.0035
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0034
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0034
1757 Myeloperoxidase MPO 0.0034
290 Prostaglandin G/H synthase 2 PTGS2 0.0034
3923 Cholinesterase BCHE 0.0033
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0033
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0033
1650 Heme carrier protein 1 SLC46A1 0.0033
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0032
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0032
172 Potassium channel subfamily K member 1 KCNK1 0.0032
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0032
84 Nuclear receptor 0B1 NR0B1 0.0032
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0032
340 Apoptotic protease-activating factor 1 APAF1 0.0032
1123 Eosinophil cationic protein RNASE3 0.0031
2391 Ferrochelatase hemH 0.0031
6502 Ferrochelatase DKFZp686P18130 0.0031
1591 Ferrochelatase, mitochondrial FECH 0.0031
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0031
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0031
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0031
6168 Solute carrier family 22 member 16 SLC22A16 0.0031
78 Acetyl-CoA acetyltransferase, mitochondrial ACAT1 0.0031
1192 Sulfotransferase 1A1 SULT1A1 0.0031
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.003
260 Cytochrome P450 51 ERG11 0.003
761 Cytochrome P450 51 ERG11 0.003
3163 Cytochrome P450 51 cyp51 0.003
469 Annexin A1 ANXA1 0.003
3856 Fibroblast growth factor receptor 3 FGFR3 0.003
26 Vascular endothelial growth factor receptor 3 FLT4 0.003
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.003
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0029
32 Vascular endothelial growth factor receptor 1 FLT1 0.0028
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0028
777 Tumor necrosis factor TNF 0.0028
284 DNA-directed RNA polymerase beta chain rpoB 0.0028
5773 DNA-directed RNA polymerase beta chain rpoB 0.0028
2105 ATP-binding cassette sub-family G member 1 ABCG1 0.0028
745 Anti-Muellerian hormone type-2 receptor AMHR2 0.0028
825 Arsenical pump-driving ATPase ASNA1 0.0028
3435 Arsenical pump-driving ATPase arsA 0.0028
486 Serine/threonine-protein kinase ALS2CR7 CDK15 0.0028
154 AFG3-like protein 2 AFG3L2 0.0028
510 Serine/threonine-protein kinase receptor R3 ACVRL1 0.0028
225 NEDD8-activating enzyme E1 regulatory subunit NAE1 0.0028
733 Activin receptor type 1B ACVR1B 0.0028
483 A-Raf proto-oncogene serine/threonine-protein kinase ARAF 0.0028
21 Beta-adrenergic receptor kinase 2 ADRBK2 0.0028
377 Beta-adrenergic receptor kinase 1 ADRBK1 0.0028
395 ALK tyrosine kinase receptor Not Available 0.0028
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0027
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0027
228 Beta platelet-derived growth factor receptor PDGFRB 0.0027
1569 G1/S-specific cyclin-D1 CCND1 0.0027
6495 Cytochrome c oxidase subunit 7C, mitochondrial COX7C 0.0027
6493 Cytochrome c oxidase subunit 6C COX6C 0.0027
6499 Cytochrome c oxidase polypeptide 7A1, mitochondrial COX7A1 0.0027
6494 Cytochrome c oxidase subunit 7B, mitochondrial COX7B 0.0027
6496 Cytochrome c oxidase subunit 8A, mitochondrial COX8A 0.0027
6498 Cytochrome c oxidase subunit 6B1 COX6B1 0.0027
6497 Cytochrome c oxidase subunit 6A2, mitochondrial COX6A2 0.0027
6491 Cytochrome c oxidase subunit 5A, mitochondrial COX5A 0.0027
6489 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial COX4I1 0.0027
6490 Cytochrome c oxidase subunit 3 MT-CO3 0.0027
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.0027
6559 Cytochrome c oxidase subunit 2 ctaC 0.0027
6669 Cytochrome c oxidase subunit 2 ctaC 0.0027
371 Cytochrome c oxidase subunit 1 MT-CO1 0.0027
6558 Cytochrome c oxidase subunit 1 ctaD 0.0027
267 Plasminogen activator inhibitor 1 SERPINE1 0.0027
6824 Tyrosine-protein kinase Lyn LYN 0.0026
292 Activin receptor type-1 ACVR1 0.0026
849 Activated CDC42 kinase 1 TNK2 0.0025
1760 Aminopeptidase N ANPEP 0.0025
6843 Aminopeptidase N pepN 0.0025
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0025
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0025
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0025
117 Sterol O-acyltransferase 1 SOAT1 0.0025
2540 Choloylglycine hydrolase cbh 0.0025
5787 Angiopoietin-1 receptor TEK 0.0025
821 Acetyl-coenzyme A synthetase 2-like, mitochondrial ACSS1 0.0024
704 Long-chain-fatty-acid--CoA ligase 1 ACSL1 0.0024
386 Acetyl-coenzyme A synthetase, cytoplasmic ACSS2 0.0024
297 Adenylate cyclase type 1 ADCY1 0.0024
289 Cytosolic purine 5'-nucleotidase NT5C2 0.0024
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0024
823 Fibroblast growth factor receptor 2 FGFR2 0.0024
6221 Steroid hormone receptor ERR1 ESRRA 0.0024
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0024
146 Androgen receptor AR 0.0024
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0024
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0024
5934 Cytochrome P450 26A1 CYP26A1 0.0023
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0023
484 Tyrosine-protein kinase ABL2 ABL2 0.0023
1010 Cytochrome P450 51A1 CYP51A1 0.0023
6501 Fatty acid-binding protein, liver FABP1 0.0023
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.0023
1714 Mitogen-activated protein kinase 3 MAPK3 0.0022
6149 Solute carrier family 22 member 10 SLC22A10 0.0021
869 Estrogen receptor beta ESR2 0.0021
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0021
740 Argininosuccinate synthase ASS1 0.0021
865 Argininosuccinate synthase ASS1 0.0021
2680 Argininosuccinate synthase argG 0.0021
3194 Argininosuccinate synthase argG 0.0021
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0021
558 Solute carrier family 12 member 1 SLC12A1 0.002
76 Nitric-oxide synthase, brain NOS1 0.002
661 ADP/ATP translocase 1 SLC25A4 0.002
6085 Fatty acid-binding protein, intestinal FABP2 0.002
6021 Adenosine kinase ADK 0.002
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.002
242 Asparagine synthetase [glutamine-hydrolyzing] ASNS 0.002
1630 Integrin beta-2 ITGB2 0.002
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.002
489 Monocarboxylate transporter 2 SLC16A7 0.002
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0019
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.0019
6837 Serine/threonine-protein kinase 17B STK17B 0.0019
6500 Phospholipase A2 PLA2G1B 0.0019
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0019
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0019
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0019
3917 Methylenetetrahydrofolate reductase MTHFR 0.0019
632 Alpha-1B adrenergic receptor ADRA1B 0.0019
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0018
320 5-hydroxytryptamine 1A receptor HTR1A 0.0018
342 P protein [Includes: DNA-directed DNA polymerase P 0.0018
612 P protein [Includes: DNA-directed DNA polymerase P 0.0018
3920 Methylenetetrahydrofolate reductase intermediate form MTHFR 0.0018
23 D(1A) dopamine receptor DRD1 0.0018
3763 5,10-methylenetetrahydrofolate reductase metF 0.0018
3918 5,10-methylenetetrahydrofolate reductase MTHFR 0.0018
5094 5,10-methylenetetrahydrofolate reductase metF 0.0018
59 AMT protein AMT 0.0018
3919 Methionyl-tRNA formyltransferase, mitochondrial MTFMT 0.0018
1202 10-formyltetrahydrofolate dehydrogenase ALDH1L1 0.0018
291 Nitric-oxide synthase, endothelial NOS3 0.0018
871 Glucocorticoid receptor NR3C1 0.0018
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0018
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0018
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0018
1176 Mitogen-activated protein kinase 1 MAPK1 0.0018
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0017
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0017
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0017
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0017
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0017
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0017
502 5-hydroxytryptamine 2A receptor HTR2A 0.0017
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0017
831 D(2) dopamine receptor DRD2 0.0017
517 Alcohol dehydrogenase 1C ADH1C 0.0017
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.0017
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0016
492 Histamine H1 receptor HRH1 0.0016
556 Alpha-1A adrenergic receptor ADRA1A 0.0016
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0016
6044 Serum paraoxonase/lactonase 3 PON3 0.0016
921 Glutamate receptor 2 GRIA2 0.0016
702 UMP-CMP kinase CMPK1 0.0016
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0016
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0016
296 Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial MTHFD2 0.0015
6599 HTH-type transcriptional regulator ttgR ttgR 0.0015
124 Histamine H2 receptor HRH2 0.0015
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0015
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0015
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0015
572 Integrin alpha-L ITGAL 0.0015
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0015
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0015
2599 Tyrosine-protein kinase HCK HCK 0.0015
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0014
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0014
357 Carbonic anhydrase 2 CA2 0.0014
1353 DNA topoisomerase 1 TOP1 0.0014
3552 DNA topoisomerase 1 topA 0.0014
3884 SHMT2 protein SHMT2 0.0014
3901 SHMT2 protein SHMT2 0.0014
3885 Hypothetical protein DKFZp686P09201 DKFZp686P09201 0.0014
3879 Serine hydroxymethyltransferase 2 Not Available 0.0014
321 Serine hydroxymethyltransferase, mitochondrial SHMT2 0.0014
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0014
1313 Lactoylglutathione lyase GLO1 0.0014
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0014
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.0014
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.0014
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.0014
914 Formimidoyltransferase-cyclodeaminase FTCD 0.0014
4122 Histone deacetylase 2 HDAC2 0.0014
679 C-1-tetrahydrofolate synthase, cytoplasmic MTHFD1 0.0013
809 Methionine synthase MTR 0.0013
2935 Methionine synthase metH 0.0013
4773 Deoxycytidine kinase DCK 0.0013
6218 Pannexin-1 PANX1 0.0013
367 Serine hydroxymethyltransferase, cytosolic SHMT1 0.0012
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.0012
824 Sodium-dependent serotonin transporter SLC6A4 0.0012
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.0012
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0011
5818 Folate receptor alpha FOLR1 0.0011
6220 Aryl hydrocarbon receptor AHR 0.0011
6042 Prostaglandin reductase 2 PTGR2 0.0011
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.001
6043 Putative G-protein coupled receptor 44 GPR44 0.001
293 Gamma-glutamyl hydrolase GGH 0.001
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.001
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.001
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.001
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0009
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0009
465 Calmodulin CALM1 0.0008
2981 Phospholipase A2, membrane associated PLA2G2A 0.0008
3810 Catechol O-methyltransferase COMT 0.0008
4043 Glutaredoxin-2, mitochondrial GLRX2 0.0007
4034 Glutaredoxin-1 GLRX 0.0007
910 Epididymal secretory glutathione peroxidase GPX5 0.0007
903 Glutathione S-transferase A5 GSTA5 0.0007
4037 Hypothetical protein GPX1 0.0007
4297 Hypothetical protein SP_1951 0.0007
4521 Hypothetical protein BC_2969 0.0007
4540 Hypothetical protein TM_1070 0.0007
4555 Hypothetical protein MT1739 0.0007
4569 Hypothetical protein mshD 0.0007
4578 Hypothetical protein PA3270 0.0007
4747 Hypothetical protein PA3967 0.0007
5177 Hypothetical protein TM_0096 0.0007
5194 Hypothetical protein PA1204 0.0007
5240 Hypothetical protein Rv2991 0.0007
5370 Hypothetical protein TM_1158 0.0007
5710 Hypothetical protein Tb927.5.1360 0.0007
1928 Leukotriene C4 synthase LTC4S 0.0007
4029 Microsomal glutathione S-transferase 3 MGST3 0.0007
4032 Microsomal glutathione S-transferase 1 MGST1 0.0007
4030 Thioredoxin domain-containing protein 12 TXNDC12 0.0007
4040 Glutathione peroxidase 7 GPX7 0.0007
907 Glutathione peroxidase 2 GPX2 0.0007
4038 Glutathione peroxidase 4 GPX4 0.0007
1975 Phospholipid hydroperoxide glutathione peroxidase, mitochondrial GPX4 0.0007
906 Glutathione peroxidase 1 GPX1 0.0007
4039 CDNA FLJ23636 fis, clone CAS07176 GPX8 0.0007
4035 Glutathione S-transferase Mu 5 GSTM5 0.0007
4036 Glutathione peroxidase 6 GPX6 0.0007
900 Glutathione S-transferase A4 GSTA4 0.0007
911 Glutathione peroxidase 3 GPX3 0.0007
4042 Glutathione transferase omega-2 GSTO2 0.0007
4033 S-formylglutathione hydrolase ESD 0.0007
1056 Gamma-glutamyltranspeptidase 1 GGT1 0.0007
952 Dipeptidyl peptidase 4 DPP4 0.0007
3319 Hydroxyacylglutathione hydrolase HAGH 0.0007
6020 Aldehyde oxidase AOX1 0.0007
898 Glutathione S-transferase A3 GSTA3 0.0007
897 Glutathione S-transferase kappa 1 GSTK1 0.0007
909 Maleylacetoacetate isomerase GSTZ1 0.0007
899 Glutathione S-transferase Mu 3 GSTM3 0.0006
905 Glutathione transferase omega-1 GSTO1 0.0006
4041 Microsomal glutathione S-transferase 2 MGST2 0.0006
365 Dihydrofolate reductase DHFR 0.0006
2381 Dihydrofolate reductase DFR1 0.0006
2833 Dihydrofolate reductase Not Available 0.0006
2931 Dihydrofolate reductase folA 0.0006
3544 Dihydrofolate reductase folA 0.0006
3682 Dihydrofolate reductase folA 0.0006
6642 Dihydrofolate reductase folA 0.0006
6756 Dihydrofolate reductase dfrA 0.0006
2165 Glutathione S-transferase Mu 2 GSTM2 0.0006
207 Glutathione synthetase GSS 0.0006
5269 Glutathione synthetase gshB 0.0006
901 Glutathione S-transferase Mu 4 GSTM4 0.0005
3932 Glutathione S-transferase A2 GSTA2 0.0005
4031 Glutathione S-transferase A1 GSTA1 0.0005
2101 Glutathione-requiring prostaglandin D synthase HPGDS 0.0005
714 Glutathione reductase, mitochondrial GSR 0.0005
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