DT-Web: DB01232

Identification

Name

Saquinavir

Accession Number

DB01232 (APRD00623)

Type

small molecule

Description

An HIV protease inhibitor which acts as an analog of an HIV protease cleavage site. It is a highly specific inhibitor of HIV-1 and HIV-2 proteases. [PubChem]

Structure

MOL SDF PDB SMILES InChI

Categories ^(*)

Molecular Weight

670.8408

Groups

approved

Monoisotopic Weight

670.38426874

Pharmacology

Indication

For the treatment of HIV-1 with advanced immunodeficiency together with antiretroviral nucleoside analogues.

Mechanism of action

Saquinavir inhibits the HIV viral proteinase enzyme which prevents cleavage of the gag-pol polyprotein, resulting in noninfectious, immature viral particles.

Absorption

Absolute bioavailability averages 4%

Protein binding

98%

Biotransformation

Hepatic

Route of elimination

In vitro studies using human liver microsomes have shown that the metabolism of saquinavir is cytochrome P450 mediated with the specific isoenzyme, CYP3A4, responsible for more than 90% of the hepatic metabolism. Only 1% of saquinavir is excreted in the urine, so the impact of renal impairment on saquinavir elimination should be minimal.

Toxicity

Probably experience pain in the throat

Affected organisms

Human Immunodeficiency Virus

Interactions

Drug Interactions

Drug	Mechanism of interaction
Abacavir	The serum concentration of Abacavir may be decreased by protease inhibitors such as Saquinavir. The antiviral response should be closely monitored.
Abiraterone	Strong CYP3A4 inhibitors may increase levels of abiraterone. Monitor concomitant therapy closely.
Alprazolam	The protease inhibitor, saquinavir, may increase the effect of the benzodiazepine, alprazolam.
Amiodarone	The protease inhibitor, saquinavir, may increase the effect and toxicity of amiodarone.
Artemether	Additive QTc-prolongation may occur. Concomitant therapy should be avoided.
Asenapine	Increased incidence of adverse effects due to pharmacodynamic synergism. Concomitant therapy should be avoided.
Astemizole	Increased risk of cardiotoxicity and arrhythmias
Atorvastatin	Saquinavir may increase the serum concentration of atorvastatin by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of atorvastatin if saquinavir is initiated, discontinued or dose changed.
Bromazepam	Saquinavir, a strong CYP3A4 inhibitor, may increase the serum concentration of bromazepam by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of bromazepam if saquinavir is initiated, discontinued or dose changed. Dosage adjustments may be required.
Cabazitaxel	Concomitant therapy with a strong CYP3A4 inhibitor may increase concentrations of cabazitaxel. Avoid concomitant therapy.
Chlordiazepoxide	The protease inhibitor, saquinavir, may increase the effect of the benzodiazepine, chlordiazepoxide.
Cisapride	Increased risk of cardiotoxicity and arrhythmias
Clonazepam	The protease inhibitor, saquinavir, may increase the effect of the benzodiazepine, clonazepam.
Clorazepate	The protease inhibitor, saquinavir, may increase the effect of the benzodiazepine, clorazepate.
Cyclosporine	The protease inhibitor, saquinavir, may increase the effect of cyclosporine.
Dantrolene	Saquinavir may increase the serum concentration of dantrolene by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of dantrolene if saquinavir is initiated, discontinued or dose changed.
Darunavir	Decreased levels of darunavir
Delavirdine	Increases the effect of saquinavir and hepatic toxicity
Diazepam	The protease inhibitor, saquinavir, may increase the effect of the benzodiazepine, diazepam.
Dihydroergotamine	The protease inhibitor, saquinavir, may increase the effect and toxicity of the ergot derivative, dihydroergotamine.
Efavirenz	Efavirenz decreases the effect of saquinavir
Eplerenone	This CYP3A4 inhibitor increases the effect and toxicity of eplerenone
Ergotamine	The protease inhibitor, saquinavir, may increase the effect and toxicity of the ergot derivative, ergotamine.
Erlotinib	This CYP3A4 inhibitor increases levels/toxicity of erlotinib
Estazolam	The protease inhibitor, saquinavir, may increase the effect of the benzodiazepine, estazolam.
Etravirine	Etravirine, when used concomitantly with protease inhibitors, may experience a decrease in serum concentration. Protease inhibitors, when used concomitantly with etravirine, may experience an increase in serum concentration. Ritonavir boosting of etravirine therapy is a requirement to concurrent therapy. In addition, it is recommended to monitor serum concentrations of the antiretrovirals, as well as to monitor antiretroviral therapy for efficacy.
Fentanyl	The protease inhibitor, saquinavir, may increase the effect and toxicity of fentanyl.
Flurazepam	The protease inhibitor, saquinavir, may increase the effect of the benzodiazepine, flurazepam.
Fusidic Acid	The protease inhibitor, saquinavir, may increase the effect and toxicity of fusidic acid.
Indinavir	Possible antagonism of action
Ketoconazole	Ketoconazole may increase the effect and toxicity of saquinavir.
Lovastatin	Saquinavir may increase the effect and toxicity of lovastatin. Concomitant therapy is contraindicated.
Midazolam	The protease inhibitor, saquinavir, may increase the effect of the benzodiazepine, midazolam.
Nevirapine	Decreases the effect of saquinavir
Pazopanib	Affects CYP3A4 metabolism therefore will decrease levels or effect of pazopanib. Consider alternate therapy.
Pimozide	The protease inhibitor, saquinavir, may increase the effect and toxicity of pimozide.
Ponatinib	Strong CYP3A4 inhibitors may increase levels of ponatinib. Monitor concomitant therapy closely.
Ranolazine	Increased levels of ranolazine - risk of toxicity
Rifabutin	Rifabutin decreases the effect of saquinavir
Rifampin	Rifampin decreases the effect of saquinavir
Tacrolimus	The protease inhibitor, Saquinavir, may increase the blood concentration of Tacrolimus. Monitor for changes in the therapeutic/toxic effects of Tacrolimus if Saquinavir therapy is initiated, discontinued or altered.
Tadalafil	Saquinavir may reduce the metabolism of Tadalafil. Concomitant therapy should be avoided if possible due to high risk of Tadalafil toxicity.
Tamoxifen	Saquinavir may increase the serum concentration of Tamoxifen by decreasing its metabolism. Monitor for increased adverse/toxic effects of Tamoxifen.
Tamsulosin	Saquinavir, a CYP3A4 inhibitor, may decrease the metabolism and clearance of Tamsulosin, a CYP3A4 substrate. Monitor for changes in therapeutic/adverse effects of Tamsulosin if Saquinavir is initiated, discontinued, or dose changed.
Telavancin	Additive QTc-prolongation may occur. Concomitant therapy should be avoided.
Telithromycin	Saquinavir may increase the plasma concentration of Telithromycin. Consider alternate therapy or monitor therapeutic/adverse effects.
Temsirolimus	Saquinavir may inhibit the metabolism and clearance of Temsirolimus. Concomitant therapy should be avoided.
Teniposide	The strong CYP3A4 inhibitor, Saquinavir, may decrease the metabolism and clearance of Teniposide, a CYP3A4 substrate. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Teniposide if Saquinavir is initiated, discontinued or dose changed.
Terfenadine	Increased risk of cardiotoxicity and arrhythmias
Tiagabine	The strong CYP3A4 inhibitor, Saquinavir, may decrease the metabolism and clearance of Tiagabine, a CYP3A4 substrate. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Tiagabine if Saquinavir is initiated, discontinued or dose changed.
Tipranavir	Tipranavir, co-administered with Ritonavir, may decrease the plasma concentration of Saquinavir. Consider alternate therapy.
Tolterodine	Saquinavir may decrease the metabolism and clearance of Tolterodine. Adjust Tolterodine dose and monitor for efficacy and toxicity.
Tolvaptan	Saquinavir is a strong inhibitor of CYP3A4 and will increase serum concentrations of tolvaptan.
Topotecan	The p-glycoprotein inhibitor, Saquinavir, may increase the bioavailability of oral Topotecan. A clinically significant effect is also expected with IV Topotecan. Concomitant therapy should be avoided.
Tramadol	Saquinavir may increase Tramadol toxicity by decreasing Tramadol metabolism and clearance.
Trazodone	The protease inhibitor, Saquinavir, may increase the efficacy/toxicity of Trazodone by inhibiting Trazodone metabolism and clearance. Monitor for changes in Trazodone efficacy/toxicity if Saquinavir is initiated, discontinued or dose changed.
Triazolam	The protease inhibitor, saquinavir, may increase the effect of the benzodiazepine, triazolam.
Trimipramine	The strong CYP3A4 inhibitor, Saquinavir, may decrease the metabolism and clearance of Trimipramine, a CYP3A4 substrate. Consider alternate therapy or monitor for changes in therapeutic and adverse effects of Trimipramine if Saquinavir is initiated, discontinued or dose changed.
Vardenafil	Saquinavir, a strong CYP3A4 inhibitor, may reduce the metabolism and clearance of Vardenafil. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of Vardenafil.
Vemurafenib	Strong CYP3A4 inhibitors may increase levels of vemurafenib. Monitor concomitant therapy closely.
Venlafaxine	Saquinavir, a CYP3A4 inhibitor, may decrease the metabolism and clearance of Venlafaxine, a CYP3A4 substrate. Monitor for changes in therapeutic/adverse effects of Venlafaxine if Saquinavir is initiated, discontinued, or dose changed.
Verapamil	Saquinavir, a strong CYP3A4 inhibitor, may increase the serum concentration of Veramapil, a CYP3A4 substrate, by decreasing its metabolism and clearance. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Verapamil if Saquinavir is initiated, discontinued or dose changed.
Vinblastine	Saquinavir, a strong CYP3A4 inhibitor, may decrease the metabolism of Vinblastine. Consider alternate therapy to avoid Vinblastine toxicity. Monitor for changes in the therapeutic/adverse effects of Vinblastine if Saquinavir is initiated, discontinued or dose changed.
Vincristine	Saquinavir, a strong CYP3A4 inhibitor, may increase the serum concentration of Vincristine by decreasing its metabolism. Consider alternate therapy to avoid Vincristine toxicity. Monitor for changes in the therapeutic and adverse effects of Vincristine if Saquinavir is initiated, discontinued or dose changed.
Vinorelbine	Saquinavir, a strong CYP3A4 inhibitor, may increase the serum concentration of Vinorelbine by decreasing its metabolism. Consider alternate therapy to avoid Vinorelbine toxicity. Monitor for changes in the therapeutic and adverse effects of Vinorelbine if Saquinavir is initiated, discontinued or dose changed.
Voriconazole	Voriconazole may increase the serum concentration of saquinavir by decreasing its metabolism. Saquinavir may increase the serum concentration of voriconazole. Monitor for changes in the therapeutic and adverse effects of both agents if concomitant therapy is initiated, discontinued or if doses are changed.
Zolpidem	Saquinavir, a strong CYP3A4 inhibitor, may increase the serum concentration of zolpidem by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of zolpidem if saquinavir is initiated, discontinued or dose changed.
Zonisamide	Saquinavir, a strong CYP3A4 inhibitor, may increase the serum concentration of zonisamide by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of zonisamide if saquinavir is initiated, discontinued or dose changed.
Zopiclone	Saquinavir, a strong CYP3A4 inhibitor, may increase the serum concentration of zopiclone by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of zopiclone if saquinavir is initiated, discontinued or dose changed.

Food Interactions

Take after a full meal.

HIV-1 protease
Name	HIV-1 protease
Gene Name	HIV-1 protease
Pharmacological action	yes
Actions	inhibitor
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed Wittayanarakul K, Hannongbua S, Feig M: Accurate prediction of protonation state as a prerequisite for reliable MM-PB(GB)SA binding free energy calculations of HIV-1 protease inhibitors. J Comput Chem. 2007 Sep 11;. - Pubmed Dandache S, Sevigny G, Yelle J, Stranix BR, Parkin N, Schapiro JM, Wainberg MA, Wu JJ: In Vitro Antiviral Activity and Cross-Resistance Profile of PL-100, a Next Generation Protease Inhibitor of Human Immunodeficiency Virus Type 1. Antimicrob Agents Chemother. 2007 Jul 16;. - Pubmed Dandache S, Coburn CA, Oliveira M, Allison TJ, Holloway MK, Wu JJ, Stranix BR, Panchal C, Wainberg MA, Vacca JP: PL-100, a novel HIV-1 protease inhibitor displaying a high genetic barrier to resistance: an in vitro selection study. J Med Virol. 2008 Dec;80(12):2053-63. - Pubmed Rhee SY, Taylor J, Fessel WJ, Kaufman D, Towner W, Troia P, Ruane P, Hellinger J, Shirvani V, Zolopa A, Shafer RW: HIV-1 protease mutations and protease inhibitor cross-resistance. Antimicrob Agents Chemother. 2010 Oct;54(10):4253-61. Epub 2010 Jul 26. - Pubmed Alcaro S, Artese A, Ceccherini-Silberstein F, Ortuso F, Perno CF, Sing T, Svicher V: Molecular dynamics and free energy studies on the wild-type and mutated HIV-1 protease complexed with four approved drugs: mechanism of binding and drug resistance. J Chem Inf Model. 2009 Jul;49(7):1751-61. - Pubmed
DTHybrid score	0.3788

Cytochrome P450 3A7
Name	Cytochrome P450 3A7
Gene Name	CYP3A7
Actions	substrate,inhibitor
References	Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table
DTHybrid score	0.4885
Cytochrome P450 3A5
Name	Cytochrome P450 3A5
Gene Name	CYP3A5
Actions	substrate,inhibitor
References	Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.6335
Cytochrome P450 3A4
Name	Cytochrome P450 3A4
Gene Name	CYP3A4
Actions	substrate,inhibitor
References	Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed Ekins S, Bravi G, Wikel JH, Wrighton SA: Three-dimensional-quantitative structure activity relationship analysis of cytochrome P-450 3A4 substrates. J Pharmacol Exp Ther. 1999 Oct;291(1):424-33. - Pubmed
DTHybrid score	1.1786
Cholesterol side-chain cleavage enzyme, mitochondrial
Name	Cholesterol side-chain cleavage enzyme, mitochondrial
Gene Name	CYP11A1
Actions	substrate
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.2137
Cytochrome P450 2C19
Name	Cytochrome P450 2C19
Gene Name	CYP2C19
Actions	inhibitor
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.6844
Cytochrome P450 2C8
Name	Cytochrome P450 2C8
Gene Name	CYP2C8
Actions	inhibitor
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.5917
Cytochrome P450 2C9
Name	Cytochrome P450 2C9
Gene Name	CYP2C9
Actions	inhibitor
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.7728
Cytochrome P450 2D6
Name	Cytochrome P450 2D6
Gene Name	CYP2D6
Actions	substrate,inhibitor
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.7671

Multidrug resistance protein 1
Name	Multidrug resistance protein 1
Gene Name	ABCB1
Actions	substrate,inhibitor,inducer
References	Perloff MD, von Moltke LL, Fahey JM, Daily JP, Greenblatt DJ: Induction of P-glycoprotein expression by HIV protease inhibitors in cell culture. AIDS. 2000 Jun 16;14(9):1287-9. - Pubmed Choo EF, Leake B, Wandel C, Imamura H, Wood AJ, Wilkinson GR, Kim RB: Pharmacological inhibition of P-glycoprotein transport enhances the distribution of HIV-1 protease inhibitors into brain and testes. Drug Metab Dispos. 2000 Jun;28(6):655-60. - Pubmed Schwab D, Fischer H, Tabatabaei A, Poli S, Huwyler J: Comparison of in vitro P-glycoprotein screening assays: recommendations for their use in drug discovery. J Med Chem. 2003 Apr 24;46(9):1716-25. - Pubmed Kim AE, Dintaman JM, Waddell DS, Silverman JA: Saquinavir, an HIV protease inhibitor, is transported by P-glycoprotein. J Pharmacol Exp Ther. 1998 Sep;286(3):1439-45. - Pubmed Huisman MT, Smit JW, Wiltshire HR, Hoetelmans RM, Beijnen JH, Schinkel AH: P-glycoprotein limits oral availability, brain, and fetal penetration of saquinavir even with high doses of ritonavir. Mol Pharmacol. 2001 Apr;59(4):806-13. - Pubmed Troutman MD, Thakker DR: Novel experimental parameters to quantify the modulation of absorptive and secretory transport of compounds by P-glycoprotein in cell culture models of intestinal epithelium. Pharm Res. 2003 Aug;20(8):1210-24. - Pubmed Eagling VA, Profit L, Back DJ: Inhibition of the CYP3A4-mediated metabolism and P-glycoprotein-mediated transport of the HIV-1 protease inhibitor saquinavir by grapefruit juice components. Br J Clin Pharmacol. 1999 Oct;48(4):543-52. - Pubmed Collett A, Tanianis-Hughes J, Hallifax D, Warhurst G: Predicting P-glycoprotein effects on oral absorption: correlation of transport in Caco-2 with drug pharmacokinetics in wild-type and mdr1a(-/-) mice in vivo. Pharm Res. 2004 May;21(5):819-26. - Pubmed
DTHybrid score	0.8627
Solute carrier family 22 member 1
Name	Solute carrier family 22 member 1
Gene Name	SLC22A1
Actions	inhibitor
References	Zhang L, Gorset W, Washington CB, Blaschke TF, Kroetz DL, Giacomini KM: Interactions of HIV protease inhibitors with a human organic cation transporter in a mammalian expression system. Drug Metab Dispos. 2000 Mar;28(3):329-34. - Pubmed
DTHybrid score	0.3288
Solute carrier organic anion transporter family member 1A2
Name	Solute carrier organic anion transporter family member 1A2
Gene Name	SLCO1A2
Actions	inhibitor
References	Cvetkovic M, Leake B, Fromm MF, Wilkinson GR, Kim RB: OATP and P-glycoprotein transporters mediate the cellular uptake and excretion of fexofenadine. Drug Metab Dispos. 1999 Aug;27(8):866-71. - Pubmed
DTHybrid score	0.3846
ATP-binding cassette sub-family G member 2
Name	ATP-binding cassette sub-family G member 2
Gene Name	ABCG2
Actions	inhibitor
References	Gupta A, Zhang Y, Unadkat JD, Mao Q: HIV protease inhibitors are inhibitors but not substrates of the human breast cancer resistance protein (BCRP/ABCG2). J Pharmacol Exp Ther. 2004 Jul;310(1):334-41. Epub 2004 Mar 8. - Pubmed Janneh O, Owen A, Chandler B, Hartkoorn RC, Hart CA, Bray PG, Ward SA, Back DJ, Khoo SH: Modulation of the intracellular accumulation of saquinavir in peripheral blood mononuclear cells by inhibitors of MRP1, MRP2, P-gp and BCRP. AIDS. 2005 Dec 2;19(18):2097-102. - Pubmed
DTHybrid score	0.4371
Solute carrier organic anion transporter family member 1B1
Name	Solute carrier organic anion transporter family member 1B1
Gene Name	SLCO1B1
Actions	inhibitor
References	Tirona RG, Leake BF, Wolkoff AW, Kim RB: Human organic anion transporting polypeptide-C (SLC21A6) is a major determinant of rifampin-mediated pregnane X receptor activation. J Pharmacol Exp Ther. 2003 Jan;304(1):223-8. - Pubmed
DTHybrid score	0.3978
Multidrug resistance-associated protein 1
Name	Multidrug resistance-associated protein 1
Gene Name	ABCC1
Actions	substrate
References	Williams GC, Liu A, Knipp G, Sinko PJ: Direct evidence that saquinavir is transported by multidrug resistance-associated protein (MRP1) and canalicular multispecific organic anion transporter (MRP2). Antimicrob Agents Chemother. 2002 Nov;46(11):3456-62. - Pubmed
DTHybrid score	0.3633
Canalicular multispecific organic anion transporter 1
Name	Canalicular multispecific organic anion transporter 1
Gene Name	ABCC2
Actions	substrate
References	Williams GC, Liu A, Knipp G, Sinko PJ: Direct evidence that saquinavir is transported by multidrug resistance-associated protein (MRP1) and canalicular multispecific organic anion transporter (MRP2). Antimicrob Agents Chemother. 2002 Nov;46(11):3456-62. - Pubmed Huisman MT, Smit JW, Crommentuyn KM, Zelcer N, Wiltshire HR, Beijnen JH, Schinkel AH: Multidrug resistance protein 2 (MRP2) transports HIV protease inhibitors, and transport can be enhanced by other drugs. AIDS. 2002 Nov 22;16(17):2295-301. - Pubmed Zelcer N, Huisman MT, Reid G, Wielinga P, Breedveld P, Kuil A, Knipscheer P, Schellens JH, Schinkel AH, Borst P: Evidence for two interacting ligand binding sites in human multidrug resistance protein 2 (ATP binding cassette C2). J Biol Chem. 2003 Jun 27;278(26):23538-44. Epub 2003 Apr 17. - Pubmed Honda Y, Ushigome F, Koyabu N, Morimoto S, Shoyama Y, Uchiumi T, Kuwano M, Ohtani H, Sawada Y: Effects of grapefruit juice and orange juice components on P-glycoprotein- and MRP2-mediated drug efflux. Br J Pharmacol. 2004 Dec;143(7):856-64. Epub 2004 Oct 25. - Pubmed
DTHybrid score	0.3855

Multidrug resistance protein 1
Name	Multidrug resistance protein 1
Gene Name	ABCB1
Actions
References	Not Available
DTHybrid score	0.8627
Solute carrier family 22 member 1
Name	Solute carrier family 22 member 1
Gene Name	SLC22A1
Actions
References	Not Available
DTHybrid score	0.3288
Solute carrier organic anion transporter family member 1A2
Name	Solute carrier organic anion transporter family member 1A2
Gene Name	SLCO1A2
Actions
References	Not Available
DTHybrid score	0.3846
ATP-binding cassette sub-family G member 2
Name	ATP-binding cassette sub-family G member 2
Gene Name	ABCG2
Actions
References	Not Available
DTHybrid score	0.4371
Solute carrier organic anion transporter family member 1B1
Name	Solute carrier organic anion transporter family member 1B1
Gene Name	SLCO1B1
Actions
References	Not Available
DTHybrid score	0.3978
Multidrug resistance-associated protein 1
Name	Multidrug resistance-associated protein 1
Gene Name	ABCC1
Actions
References	Not Available
DTHybrid score	0.3633
Canalicular multispecific organic anion transporter 1
Name	Canalicular multispecific organic anion transporter 1
Gene Name	ABCC2
Actions
References	Not Available
DTHybrid score	0.3855

Id	Partner name	Gene Name	Score
4200	Cytochrome P450 1A2	CYP1A2	0.4708
6030	Cytochrome P450 2B6	CYP2B6	0.3226
6013	Cytochrome P450 2E1	CYP2E1	0.231
6024	Cytochrome P450 1A1	CYP1A1	0.2101
6157	Solute carrier organic anion transporter family member 1B3	SLCO1B3	0.1856
1729	Solute carrier family 22 member 6	SLC22A6	0.1644
20	Prostaglandin G/H synthase 1	PTGS1	0.159
6144	Solute carrier family 22 member 2	SLC22A2	0.1576
5718	Cytochrome P450 2A6	CYP2A6	0.1527
776	Bile salt export pump	ABCB11	0.1524
6142	Solute carrier family 22 member 8	SLC22A8	0.136
2164	Multidrug resistance-associated protein 4	ABCC4	0.1177
1709	Canalicular multispecific organic anion transporter 2	ABCC3	0.1172
6022	UDP-glucuronosyltransferase 1-1	UGT1A1	0.1167
1632	Solute carrier organic anion transporter family member 2B1	SLCO2B1	0.1158
3811	Cytochrome P450 19A1	CYP19A1	0.1117
1898	Cytochrome P450 1B1	CYP1B1	0.1086
6106	Cytochrome P450 2C18	CYP2C18	0.1061
118	Organic cation/carnitine transporter 2	SLC22A5	0.1061
492	Histamine H1 receptor	HRH1	0.1046
6143	Solute carrier family 22 member 7	SLC22A7	0.0982
220	Sodium channel protein type 5 subunit alpha	SCN5A	0.0971
6178	UDP-glucuronosyltransferase 2B7	UGT2B7	0.0971
824	Sodium-dependent serotonin transporter	SLC6A4	0.0962
556	Alpha-1A adrenergic receptor	ADRA1A	0.09
290	Prostaglandin G/H synthase 2	PTGS2	0.0871
6141	Sodium/bile acid cotransporter	SLC10A1	0.0865
6147	Solute carrier family 22 member 3	SLC22A3	0.0845
540	Sodium-dependent noradrenaline transporter	SLC6A2	0.0837
502	5-hydroxytryptamine 2A receptor	HTR2A	0.0822
831	D(2) dopamine receptor	DRD2	0.0807
320	5-hydroxytryptamine 1A receptor	HTR1A	0.0783
136	Estrogen receptor	ESR1	0.0779
6018	UDP-glucuronosyltransferase 1-9	UGT1A9	0.0775
1024	Solute carrier family 22 member 11	SLC22A11	0.0736
833	Organic cation/carnitine transporter 1	SLC22A4	0.073
6176	UDP-glucuronosyltransferase 1-3	UGT1A3	0.0725
6158	Solute carrier organic anion transporter family member 1C1	SLCO1C1	0.0724
6148	Multidrug resistance-associated protein 7	ABCC10	0.0704
817	DNA topoisomerase 2-alpha	TOP2A	0.0695
872	Gamma-aminobutyric-acid receptor subunit alpha-1	GABRA1	0.0686
6150	Solute carrier organic anion transporter family member 4C1	SLCO4C1	0.0666
101	Potassium voltage-gated channel subfamily H member 2	KCNH2	0.0664
847	Mu-type opioid receptor	OPRM1	0.0661
631	3-hydroxy-3-methylglutaryl-coenzyme A reductase	HMGCR	0.0657
3387	3-hydroxy-3-methylglutaryl-coenzyme A reductase	mvaA	0.0657
103	Muscarinic acetylcholine receptor M1	CHRM1	0.0637
766	Beta-2 adrenergic receptor	ADRB2	0.0633
871	Glucocorticoid receptor	NR3C1	0.0624
632	Alpha-1B adrenergic receptor	ADRA1B	0.0612
805	Cytochrome P450 11B1, mitochondrial	CYP11B1	0.0589
617	Muscarinic acetylcholine receptor M2	CHRM2	0.0586
6031	Cytochrome P450 3A43	CYP3A43	0.0585
51	Muscarinic acetylcholine receptor M3	CHRM3	0.056
6137	Multidrug resistance-associated protein 6	ABCC6	0.0558
23	D(1A) dopamine receptor	DRD1	0.0558
193	Beta-1 adrenergic receptor	ADRB1	0.0544
6153	Solute carrier organic anion transporter family member 4A1	SLCO4A1	0.0544
756	Sex hormone-binding globulin	SHBG	0.0539
70	Type-1 angiotensin II receptor	AGTR1	0.0534
380	Cytochrome P450 17A1	CYP17A1	0.0534
844	Epidermal growth factor receptor	EGFR	0.0528
238	Peroxisome proliferator-activated receptor gamma	PPARG	0.0519
318	Alpha-2A adrenergic receptor	ADRA2A	0.0507
1284	Nuclear receptor subfamily 1 group I member 2	NR1I2	0.0506
713	Sodium-dependent dopamine transporter	SLC6A3	0.0505
696	Kappa-type opioid receptor	OPRK1	0.0499
467	Delta-type opioid receptor	OPRD1	0.0497
1539	Oligopeptide transporter, small intestine isoform	SLC15A1	0.0464
341	5-hydroxytryptamine 3 receptor	HTR3A	0.0463
146	Androgen receptor	AR	0.0461
260	Cytochrome P450 51	ERG11	0.0458
761	Cytochrome P450 51	ERG11	0.0458
3163	Cytochrome P450 51	cyp51	0.0458
3941	Amine oxidase [flavin-containing] A	MAOA	0.0452
468	Cytochrome P450 4A11	CYP4A11	0.0441
789	Alpha-1D adrenergic receptor	ADRA1D	0.0441
6136	Multidrug resistance-associated protein 5	ABCC5	0.0433
738	Monocarboxylate transporter 1	SLC16A1	0.0427
590	5-hydroxytryptamine 2C receptor	HTR2C	0.0417
6140	Ileal sodium/bile acid cotransporter	SLC10A2	0.0415
6182	Cytochrome P450 2J2	CYP2J2	0.0411
385	Potassium-transporting ATPase alpha chain 1	ATP4A	0.041
274	Muscarinic acetylcholine receptor M5	CHRM5	0.0408
3923	Cholinesterase	BCHE	0.0405
33	Cystine/glutamate transporter	SLC7A11	0.0404
230	ATP-binding cassette transporter sub-family C member 8	ABCC8	0.0397
450	Muscarinic acetylcholine receptor M4	CHRM4	0.0397
891	Dihydropteroate synthase	folP	0.0394
5359	Dihydropteroate synthase	folP	0.0394
7175	Dihydropteroate synthase	sulI	0.0394
4604	Liver carboxylesterase 1	CES1	0.0392
614	Progesterone receptor	PGR	0.0391
6101	Dimethylaniline monooxygenase [N-oxide-forming] 3	FMO3	0.0381
465	Calmodulin	CALM1	0.038
504	Mast/stem cell growth factor receptor	KIT	0.0373
806	Sodium/potassium-transporting ATPase alpha-1 chain	ATP1A1	0.0365
787	Vitamin K epoxide reductase complex subunit 1	VKORC1	0.0364
4115	Voltage-dependent L-type calcium channel subunit alpha-1D	CACNA1D	0.0352
885	5-hydroxytryptamine 1B receptor	HTR1B	0.0352
6104	Dimethylaniline monooxygenase [N-oxide-forming] 1	FMO1	0.0347
6160	Solute carrier organic anion transporter family member 3A1	SLCO3A1	0.0344
478	Voltage-dependent L-type calcium channel subunit alpha-1C	CACNA1C	0.0344
813	Neuronal acetylcholine receptor subunit alpha-2	CHRNA2	0.0342
737	Mineralocorticoid receptor	NR3C2	0.034
638	D(3) dopamine receptor	DRD3	0.0334
6167	Organic solute transporter subunit beta	OSTB	0.0333
6166	Organic solute transporter subunit alpha	OSTA	0.0332
869	Estrogen receptor beta	ESR2	0.0327
4111	Voltage-dependent L-type calcium channel subunit alpha-1S	CACNA1S	0.0327
29	Tubulin beta-1 chain	TUBB1	0.0323
4099	Gamma-aminobutyric-acid receptor subunit beta-3	GABRB3	0.0323
4110	Voltage-dependent L-type calcium channel subunit beta-2	CACNB2	0.032
698	B-Raf proto-oncogene serine/threonine-protein kinase	BRAF	0.0317
6180	UDP-glucuronosyltransferase 2B4	UGT2B4	0.0314
580	Gamma-aminobutyric-acid receptor subunit alpha-3	GABRA3	0.0312
423	Gamma-aminobutyric-acid receptor subunit alpha-2	GABRA2	0.031
3587	Gastrotropin	FABP6	0.0309
629	Alpha-2B adrenergic receptor	ADRA2B	0.0304
3939	Amine oxidase [flavin-containing] B	MAOB	0.0303
6155	ATP-binding cassette transporter sub-family C member 11	ABCC11	0.0302
228	Beta platelet-derived growth factor receptor	PDGFRB	0.03
378	Alpha-2C adrenergic receptor	ADRA2C	0.0299
2184	Cystic fibrosis transmembrane conductance regulator	CFTR	0.0299
26	Vascular endothelial growth factor receptor 3	FLT4	0.0296
904	Glutathione S-transferase P	GSTP1	0.0294
725	5-hydroxytryptamine 1D receptor	HTR1D	0.029
1974	Oligopeptide transporter, kidney isoform	SLC15A2	0.029
32	Vascular endothelial growth factor receptor 1	FLT1	0.0283
161	Tubulin beta chain	TUBB	0.0282
312	Tubulin beta chain	TUB2	0.0282
407	Vascular endothelial growth factor receptor 2	KDR	0.0281
373	Transthyretin	TTR	0.0281
477	DNA topoisomerase 4 subunit A	parC	0.028
886	DNA topoisomerase 4 subunit A	parC	0.028
6226	DNA topoisomerase 4 subunit A	parC	0.028
567	Receptor tyrosine-protein kinase erbB-2	ERBB2	0.0279
404	DNA gyrase subunit A	gyrA	0.0275
6224	DNA gyrase subunit A	gyrA	0.0275
1353	DNA topoisomerase 1	TOP1	0.0275
3552	DNA topoisomerase 1	topA	0.0275
523	Gamma-aminobutyric-acid receptor subunit alpha-5	GABRA5	0.0275
535	Voltage-dependent T-type calcium channel subunit alpha-1G	CACNA1G	0.0274
950	Alpha platelet-derived growth factor receptor	PDGFRA	0.0268
4120	NADPH--cytochrome P450 reductase	POR	0.0267
122	P2Y purinoceptor 12	P2RY12	0.0254
6085	Fatty acid-binding protein, intestinal	FABP2	0.0254
6023	Cytochrome P450 11B2, mitochondrial	CYP11B2	0.0247
1757	Myeloperoxidase	MPO	0.0237
2539	Tubulin alpha-1 chain	TUBA4A	0.0237
124	Histamine H2 receptor	HRH2	0.0235
6177	UDP-glucuronosyltransferase 1-10	UGT1A10	0.0227
964	Voltage-dependent T-type calcium channel subunit alpha-1H	CACNA1H	0.0226
6154	Multidrug and toxin extrusion protein 1	SLC47A1	0.0224
4773	Deoxycytidine kinase	DCK	0.0224
952	Dipeptidyl peptidase 4	DPP4	0.0223
474	Acetylcholinesterase	ACHE	0.0223
6220	Aryl hydrocarbon receptor	AHR	0.0223
762	Voltage-dependent calcium channel subunit alpha-2/delta-1	CACNA2D1	0.0222
183	Vascular endothelial growth factor A	VEGFA	0.0221
6599	HTH-type transcriptional regulator ttgR	ttgR	0.0221
432	D(4) dopamine receptor	DRD4	0.0221
17	Proto-oncogene tyrosine-protein kinase ABL1	ABL1	0.022
462	Intermediate conductance calcium-activated potassium channel protein 4	KCNN4	0.022
275	Arachidonate 5-lipoxygenase	ALOX5	0.0219
811	Translocator protein	TSPO	0.0218
4148	Serine/threonine-protein kinase mTOR	MTOR	0.0218
758	Thyroid hormone receptor alpha	THRA	0.0218
706	Glutamate [NMDA] receptor subunit 3A	GRIN3A	0.0216
3970	Voltage-dependent N-type calcium channel subunit alpha-1B	CACNA1B	0.0216
6181	UDP-glucuronosyltransferase 1-8	UGT1A8	0.0215
80	Peroxisome proliferator-activated receptor alpha	PPARA	0.0214
3947	Xanthine dehydrogenase/oxidase	XDH	0.0212
750	Voltage-dependent calcium channel gamma-1 subunit	CACNG1	0.0211
469	Annexin A1	ANXA1	0.0208
4100	Gamma-aminobutyric-acid receptor subunit beta-2	GABRB2	0.0208
530	Gamma-aminobutyric-acid receptor subunit alpha-4	GABRA4	0.0208
273	Apoptosis regulator Bcl-2	BCL2	0.0207
232	Corticosteroid-binding globulin	SERPINA6	0.0206
1517	Beta-3 adrenergic receptor	ADRB3	0.0206
102	DNA topoisomerase I, mitochondrial	TOP1MT	0.0205
5787	Angiopoietin-1 receptor	TEK	0.0204
2404	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PIK3CG	0.0203
147	Aldehyde dehydrogenase, mitochondrial	ALDH2	0.0203
841	Gamma-aminobutyric-acid receptor subunit alpha-6	GABRA6	0.0203
1050	Bile salt sulfotransferase	SULT2A1	0.0201
244	Angiotensin-converting enzyme	ACE	0.02
1010	Cytochrome P450 51A1	CYP51A1	0.0198
436	5-hydroxytryptamine 2B receptor	HTR2B	0.0195
346	Thyroid hormone receptor beta-1	THRB	0.0194
594	Thyroxine-binding globulin	SERPINA7	0.0193
768	FK506-binding protein 1A	FKBP1A	0.0192
1852	Microtubule-associated protein 2	MAP2	0.0189
40	RAF proto-oncogene serine/threonine-protein kinase	RAF1	0.0185
204	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE5A	0.0183
24	Thymidylate synthase	TMP1	0.0182
359	Thymidylate synthase	TYMS	0.0182
2626	Thymidylate synthase	thyA	0.0182
2729	Thymidylate synthase	thyA	0.0182
5352	Thymidylate synthase	THYA	0.0182
6087	Gamma-aminobutyric acid receptor subunit gamma-1	GABRG1	0.0181
6093	Gamma-aminobutyric acid receptor subunit delta	GABRD	0.0181
6089	Gamma-aminobutyric acid receptor subunit epsilon	GABRE	0.0181
6014	Cytochrome P450 2A13	CYP2A13	0.0178
5923	Microtubule-associated protein tau	MAPT	0.0177
5924	Microtubule-associated protein 4	MAP4	0.0177
6025	UDP-glucuronosyltransferase 1-4	UGT1A4	0.0177
606	Cytochrome P450 27, mitochondrial	CYP27A1	0.0175
4098	Gamma-aminobutyric-acid receptor subunit beta-1	GABRB1	0.0175
777	Tumor necrosis factor	TNF	0.0175
1656	CYP2B protein	CYP2B	0.0174
908	Glutathione S-transferase theta-1	GSTT1	0.0173
514	Potassium voltage-gated channel subfamily H member 6	KCNH6	0.0171
772	Potassium voltage-gated channel subfamily H member 7	KCNH7	0.0171
6149	Solute carrier family 22 member 10	SLC22A10	0.017
15	Voltage-dependent T-type calcium channel subunit alpha-1I	CACNA1I	0.017
1389	Transforming growth factor beta-1	TGFB1	0.0169
6086	Gamma-aminobutyric acid receptor subunit gamma-2	GABRG2	0.0168
217	Estradiol 17-beta-dehydrogenase 1	HSD17B1	0.0168
198	Sodium channel protein type 10 subunit alpha	SCN10A	0.0167
165	FL cytokine receptor	FLT3	0.0165
6169	ATP-binding cassette sub-family A member 5	ABCA5	0.0165
781	ATP-sensitive inward rectifier potassium channel 11	KCNJ11	0.0165
6099	Potassium voltage-gated channel subfamily D member 3	KCND3	0.0165
6098	Potassium voltage-gated channel subfamily D member 2	KCND2	0.0165
4237	50S ribosomal protein L22	rplV	0.0162
709	ATP-sensitive inward rectifier potassium channel 1	KCNJ1	0.0162
4113	Voltage-dependent L-type calcium channel subunit alpha-1F	CACNA1F	0.0161
6152	Solute carrier organic anion transporter family member 2A1	SLCO2A1	0.0161
716	5-hydroxytryptamine 7 receptor	HTR7	0.016
6102	Arylamine N-acetyltransferase 2	NAT2	0.0159
117	Sterol O-acyltransferase 1	SOAT1	0.0159
365	Dihydrofolate reductase	DHFR	0.0158
2381	Dihydrofolate reductase	DFR1	0.0158
2833	Dihydrofolate reductase	Not Available	0.0158
2931	Dihydrofolate reductase	folA	0.0158
3544	Dihydrofolate reductase	folA	0.0158
3682	Dihydrofolate reductase	folA	0.0158
6642	Dihydrofolate reductase	folA	0.0158
6756	Dihydrofolate reductase	dfrA	0.0158
1618	High affinity nerve growth factor receptor	NTRK1	0.0158
6088	Gamma-aminobutyric acid receptor subunit gamma-3	GABRG3	0.0158
6090	Gamma-aminobutyric acid receptor subunit pi	GABRP	0.0158
6092	Gamma-aminobutyric acid receptor subunit rho-2	GABRR2	0.0158
6115	Gamma-aminobutyric acid receptor subunit rho-3	GABRR3	0.0158
142	Gamma-aminobutyric-acid receptor subunit rho-1	GABRR1	0.0156
4177	Proto-oncogene tyrosine-protein kinase receptor ret	RET	0.0156
4238	50S ribosomal protein L4	rplD	0.0155
5578	50S ribosomal protein L4	rplD	0.0155
6173	50S ribosomal protein L4	rplD	0.0155
6219	50S ribosomal protein L4	rplD	0.0155
245	Large neutral amino acids transporter small subunit 1	SLC7A5	0.0154
13	Aminomethyltransferase, mitochondrial	AMT	0.0154
163	D(1B) dopamine receptor	DRD5	0.0151
131	Synaptic vesicular amine transporter	SLC18A2	0.0151
424	Dihydroorotate dehydrogenase, mitochondrial	DHODH	0.0151
4160	Voltage-dependent calcium channel subunit alpha-2/delta-2	CACNA2D2	0.0149
84	Nuclear receptor 0B1	NR0B1	0.0148
723	Cytosolic phospholipase A2	PLA2G4A	0.0147
858	Potassium voltage-gated channel subfamily A member 1	KCNA1	0.0147
3810	Catechol O-methyltransferase	COMT	0.0146
951	Macrophage colony-stimulating factor 1 receptor	CSF1R	0.0146
2222	Equilibrative nucleoside transporter 1	SLC29A1	0.0145
464	Glutamate [NMDA] receptor subunit epsilon-2	GRIN2B	0.0144
778	Cysteinyl leukotriene receptor 1	CYSLTR1	0.0143
634	Squalene monooxygenase	SQLE	0.0143
7196	Squalene monooxygenase	ERG1	0.0143
6541	Peptostreptococcal albumin-binding protein	pab	0.0142
6091	Gamma-aminobutyric acid receptor subunit theta	GABRQ	0.0142
94	5-hydroxytryptamine 4 receptor	HTR4	0.0142
2038	Inhibitor of nuclear factor kappa-B kinase subunit beta	IKBKB	0.0142
705	Glutamate receptor 1	GRIA1	0.0139
6079	Neuronal acetylcholine receptor subunit alpha-3	CHRNA3	0.0139
6146	High affinity copper uptake protein 1	SLC31A1	0.0138
360	Ribonucleoside-diphosphate reductase large subunit	RRM1	0.0137
1650	Heme carrier protein 1	SLC46A1	0.0137
6020	Aldehyde oxidase	AOX1	0.0136
1629	Transcription factor AP-1	JUN	0.0136
158	Sodium channel protein type 1 subunit alpha	SCN1A	0.0136
558	Solute carrier family 12 member 1	SLC12A1	0.0135
1992	Vitamin D-binding protein	GC	0.0135
818	50S ribosomal protein L10	rplJ	0.0135
581	Cytochrome P450 2R1	CYP2R1	0.0135
1630	Integrin beta-2	ITGB2	0.0135
2157	NAD(P)H dehydrogenase [quinone] 1	NQO1	0.0134
3868	Calcineurin subunit B isoform 2	PPP3R2	0.0133
421	Calcium signal-modulating cyclophilin ligand	CAMLG	0.0133
427	Substance-P receptor	TACR1	0.0133
461	Glycine receptor subunit alpha-3	GLRA3	0.0132
511	5-hydroxytryptamine 1F receptor	HTR1F	0.0131
185	Vasopressin V1a receptor	AVPR1A	0.0131
1457	Long-chain-fatty-acid--CoA ligase 4	ACSL4	0.0131
4112	Voltage-dependent L-type calcium channel subunit beta-4	CACNB4	0.013
4114	Voltage-dependent L-type calcium channel subunit beta-3	CACNB3	0.013
3307	Acriflavine resistance protein B	acrB	0.013
2808	Chloramphenicol acetyltransferase 3	cat3	0.013
1192	Sulfotransferase 1A1	SULT1A1	0.0129
259	Microsomal triglyceride transfer protein large subunit	MTTP	0.0128
322	Vasopressin V2 receptor	AVPR2	0.0128
4192	DNA topoisomerase 2-beta	TOP2B	0.0127
596	3-oxo-5-alpha-steroid 4-dehydrogenase 1	SRD5A1	0.0126
992	Protein tyrosine kinase 2 beta	PTK2B	0.0126
1256	5-hydroxytryptamine 6 receptor	HTR6	0.0125
1995	Sodium channel protein type 9 subunit alpha	SCN9A	0.0124
2183	Fatty acid-binding protein, adipocyte	FABP4	0.0124
5934	Cytochrome P450 26A1	CYP26A1	0.0123
3809	Estrogen-related receptor gamma	ESRRG	0.0122
4122	Histone deacetylase 2	HDAC2	0.0119
4095	Neuronal acetylcholine receptor subunit alpha-7	CHRNA7	0.0119
947	Neuronal acetylcholine receptor subunit alpha-4	CHRNA4	0.0119
333	Voltage-dependent L-type calcium channel subunit beta-1	CACNB1	0.0118
856	Vitamin D3 receptor	VDR	0.0118
2331	HTH-type transcriptional regulator qacR	qacR	0.0118
6461	HTH-type transcriptional regulator qacR	qacR	0.0118
528	5-hydroxytryptamine 1E receptor	HTR1E	0.0118
4203	Histamine N-methyltransferase	HNMT	0.0117
3804	Sodium channel protein type 4 subunit alpha	SCN4A	0.0117
6432	Transporter	snf	0.0116
3854	Basic fibroblast growth factor receptor 1	FGFR1	0.0116
3856	Fibroblast growth factor receptor 3	FGFR3	0.0116
6040	6-phosphogluconate dehydrogenase, decarboxylating	PGD	0.0116
199	Monocarboxylate transporter 8	SLC16A2	0.0116
642	3-oxo-5-alpha-steroid 4-dehydrogenase 2	SRD5A2	0.0115
2211	Fatty acid-binding protein, heart	FABP3	0.0114
5880	Thrombopoietin receptor	MPL	0.0114
392	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	CACNA1A	0.0114
620	Bifunctional dihydrofolate reductase-thymidylate synthase	Not Available	0.0113
1435	Synaptic vesicle glycoprotein 2A	SV2A	0.0112
6163	Copper-transporting ATPase 2	ATP7B	0.0111
6165	Copper-transporting ATPase 1	ATP7A	0.0111
837	Glutamate [NMDA] receptor subunit epsilon-1	GRIN2A	0.011
482	Glycine receptor subunit alpha-1	GLRA1	0.011
976	Platelet glycoprotein IX	GP9	0.011
6044	Serum paraoxonase/lactonase 3	PON3	0.0109
208	DNA-directed RNA polymerase beta' chain	rpoC	0.0109
5774	DNA-directed RNA polymerase beta' chain	rpoC	0.0109
896	Glutathione S-transferase Mu 1	GSTM1	0.0109
73	Prostaglandin E2 receptor, EP1 subtype	PTGER1	0.0109
7	Nitric oxide synthase, inducible	NOS2	0.0109
2443	Azurin	azu	0.0108
751	Potassium channel subfamily K member 6	KCNK6	0.0107
5626	Nucleoside diphosphate kinase B	NME2	0.0107
489	Monocarboxylate transporter 2	SLC16A7	0.0106
890	Niemann-Pick C1-like protein 1	NPC1L1	0.0105
3917	Methylenetetrahydrofolate reductase	MTHFR	0.0104
1524	Peptidyl-prolyl cis-trans isomerase A	PPIA	0.0104
6700	Peptidyl-prolyl cis-trans isomerase A	ppiA	0.0104
284	DNA-directed RNA polymerase beta chain	rpoB	0.0104
5773	DNA-directed RNA polymerase beta chain	rpoB	0.0104
6138	Multidrug resistance protein 3	ABCB4	0.0104
3932	Glutathione S-transferase A2	GSTA2	0.0103
4152	Superoxide dismutase [Cu-Zn]	SOD1	0.0103
6043	Putative G-protein coupled receptor 44	GPR44	0.0103
2449	Tubulin alpha-3 chain	TUBA1A	0.0103
1525	Heparin-binding growth factor 2	FGF2	0.0102
1864	RET proto-oncogene	RET	0.0102
295	Carbonic anhydrase 1	CA1	0.0102
572	Integrin alpha-L	ITGAL	0.0101
1950	Epithelial discoidin domain-containing receptor 1	DDR1	0.0101
6170	ATP-binding cassette sub-family A member 3	ABCA3	0.0101
6094	BCR/ABL fusion protein isoform X9	BCR/ABL fusion	0.0101
401	Glutamate [NMDA] receptor subunit zeta-1	GRIN1	0.0101
823	Fibroblast growth factor receptor 2	FGFR2	0.01
485	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	PDE3A	0.0099
6038	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6H	0.0099
5251	Carbonyl reductase [NADPH] 1	CBR1	0.0098
172	Potassium channel subfamily K member 1	KCNK1	0.0098
239	Coagulation factor X	F10	0.0098
650	Aldo-keto reductase family 1 member C3	AKR1C3	0.0098
677	Choline-phosphate cytidylyltransferase A	PCYT1A	0.0097
1502	Peroxisome proliferator-activated receptor delta	PPARD	0.0097
4116	Dihydropteroate synthetase	Not Available	0.0097
509	Thymidine kinase	TK	0.0097
570	Thymidine kinase	TK	0.0097
2559	Thymidine kinase	TK	0.0097
3430	Thymidine kinase	tdk	0.0097
3518	Thymidine kinase	TK	0.0097
5301	Thymidine kinase	tdk	0.0097
5771	Thymidine kinase	ORF36	0.0097
7009	Thymidine kinase	ORF36	0.0097
2112	Toll-like receptor 9	TLR9	0.0097
592	Carbonic anhydrase 4	CA4	0.0097
5300	Antigen peptide transporter 1	TAP1	0.0096
2180	3-phosphoinositide-dependent protein kinase 1	PDPK1	0.0096
3671	7-alpha-hydroxysteroid dehydrogenase	hdhA	0.0096
357	Carbonic anhydrase 2	CA2	0.0096
1787	Nuclear factor NF-kappa-B p105 subunit	NFKB1	0.0096
49	Endothelin B receptor	EDNRB	0.0096
241	Calcium-transporting ATPase type 2C member 1	ATP2C1	0.0095
3961	G protein-activated inward rectifier potassium channel 4	KCNJ5	0.0095
6058	Geranylgeranyl pyrophosphate synthetase	GGPS1	0.0095
1760	Aminopeptidase N	ANPEP	0.0095
6843	Aminopeptidase N	pepN	0.0095
566	Serotransferrin	TF	0.0094
603	DNA polymerase alpha catalytic subunit	POLA1	0.0094
68	Cannabinoid receptor 1	CNR1	0.0094
88	Retinoic acid receptor RXR-beta	RXRB	0.0093
521	ATP-binding cassette transporter sub-family C member 9	ABCC9	0.0093
918	Glutamate receptor, ionotropic kainate 2	GRIK2	0.0093
853	Farnesyl pyrophosphate synthetase	FDPS	0.0092
6206	DNA-directed RNA polymerase subunit beta'	rpoC	0.0092
6037	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6G	0.0092
4209	ATP-sensitive inward rectifier potassium channel 8	KCNJ8	0.0092
588	Chromodomain-helicase-DNA-binding protein 1	CHD1	0.0091
578	Endothelin-1 receptor	EDNRA	0.009
6218	Pannexin-1	PANX1	0.009
672	Prostaglandin F2-alpha receptor	PTGFR	0.009
537	ATP synthase delta chain, mitochondrial	ATP5D	0.009
6078	Neuronal acetylcholine receptor subunit beta-4	CHRNB4	0.0089
6047	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	PDE1A	0.0089
621	Periplasmic [Fe] hydrogenase 1	Not Available	0.0088
748	5'-AMP-activated protein kinase catalytic subunit alpha-1	PRKAA1	0.0088
6002	Prostaglandin E2 receptor EP4 subtype	PTGER4	0.0088
5294	Nucleoside diphosphate kinase A	NME1	0.0088
293	Gamma-glutamyl hydrolase	GGH	0.0087
3610	Thioredoxin reductase 1, cytoplasmic	TXNRD1	0.0087
319	Opioid receptor, sigma 1	OPRS1	0.0087
559	NADH-ubiquinone oxidoreductase chain 1	MT-ND1	0.0087
338	DNA polymerase	UL30	0.0086
379	DNA polymerase	UL54	0.0086
697	DNA polymerase	ORF28	0.0086
2482	DNA polymerase	43	0.0086
4104	DNA polymerase	BALF5	0.0086
132	ATP-binding cassette sub-family A member 1	ABCA1	0.0085
921	Glutamate receptor 2	GRIA2	0.0085
1178	Adenosine A2a receptor	ADORA2A	0.0085
342	P protein [Includes: DNA-directed DNA polymerase	P	0.0085
612	P protein [Includes: DNA-directed DNA polymerase	P	0.0085
2981	Phospholipase A2, membrane associated	PLA2G2A	0.0085
702	UMP-CMP kinase	CMPK1	0.0084
5692	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	PDE1B	0.0084
364	Corticosteroid 11-beta-dehydrogenase isozyme 1	HSD11B1	0.0084
814	Ryanodine receptor 1	RYR1	0.0083
6045	Voltage-dependent calcium channel subunit alpha-2/delta-3	CACNA2D3	0.0081
850	Vasopressin V1b receptor	AVPR1B	0.0081
4131	Prostaglandin E2 receptor, EP3 subtype	PTGER3	0.0081
6339	Ig kappa chain V-II region RPMI 6410	Not Available	0.0081
406	Prostaglandin E2 receptor, EP2 subtype	PTGER2	0.0081
458	Neuronal acetylcholine receptor subunit alpha-10	CHRNA10	0.0081
139	Aldo-keto reductase family 1 member C1	AKR1C1	0.0081
6151	Monocarboxylate transporter 10	SLC16A10	0.008
6836	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial	HIBCH	0.008
6837	Serine/threonine-protein kinase 17B	STK17B	0.008
4210	Toll-like receptor 4	TLR4	0.008
1196	Complement decay-accelerating factor	CD55	0.008
6525	Group IID secretory phospholipase A2	PLA2G2D	0.008
780	Retinoic acid receptor RXR-gamma	RXRG	0.0079
645	Penicillin-binding protein 1A	mrcA	0.0078
5805	Penicillin-binding protein 1A	ponA	0.0078
6185	Penicillin-binding protein 1A	mrcA	0.0078
6799	Penicillin-binding protein 1A	pbpA	0.0078
2599	Tyrosine-protein kinase HCK	HCK	0.0078
796	Inosine-5'-monophosphate dehydrogenase 2	IMPDH2	0.0078
442	Envelope glycoprotein	gp41	0.0078
4859	Envelope glycoprotein	env	0.0078
6033	High affinity interleukin-8 receptor A	CXCR1	0.0078
838	Inosine-5'-monophosphate dehydrogenase 1	IMPDH1	0.0078
1291	cAMP response element-binding protein	CREB1	0.0078
1086	Potassium voltage-gated channel subfamily KQT member 2	KCNQ2	0.0077
6210	Tubulin delta chain	TUBD1	0.0077
6211	Tubulin epsilon chain	TUBE1	0.0077
6212	Tubulin gamma-1 chain	TUBG1	0.0077
3704	Spermidine/putrescine-binding periplasmic protein precursor	potD	0.0077
563	Thyroid peroxidase	TPO	0.0076
2450	Tyrosine-protein kinase ITK/TSK	ITK	0.0076
4097	Neuronal acetylcholine receptor subunit alpha-9	CHRNA9	0.0076
153	Dopamine beta-hydroxylase	DBH	0.0076
439	Glutamate [NMDA] receptor subunit epsilon-4	GRIN2D	0.0075
78	Acetyl-CoA acetyltransferase, mitochondrial	ACAT1	0.0075
5818	Folate receptor alpha	FOLR1	0.0075
686	Aldo-keto reductase family 1 member C2	AKR1C2	0.0074
1541	Metalloproteinase	mmp20	0.0074
2021	Thrombomodulin	THBD	0.0074
6161	Probable low affinity copper uptake protein 2	SLC31A2	0.0073
6171	Solute carrier family 28 member 3	SLC28A3	0.0073
6010	Thiamine transporter 1	SLC19A2	0.0073
174	Sigma 1-type opioid receptor	SIGMAR1	0.0073
543	Penicillin-binding protein 1B	mrcB	0.0072
6186	Penicillin-binding protein 1B	ponB	0.0072
6822	Penicillin-binding protein 1b	pbp1b	0.0072
6844	Penicillin-binding protein 1b	pbp1b	0.0072
1	Peptidoglycan synthetase ftsI	ftsI	0.0071
4155	Peptidoglycan synthetase ftsI	ftsI	0.0071
54	Prothrombin	F2	0.0071
6174	50S ribosomal protein L32	rpmF	0.0071
990	Dual specificity mitogen-activated protein kinase kinase 1	MAP2K1	0.0071
571	Melatonin receptor type 1A	MTNR1A	0.007
362	Melatonin receptor type 1B	MTNR1B	0.007
459	Retinoic acid receptor RXR-alpha	RXRA	0.007
6656	UDP-glucuronosyltransferase 3A1	UGT3A1	0.007
6168	Solute carrier family 22 member 16	SLC22A16	0.007
6179	UDP-glucuronosyltransferase 2B17	UGT2B17	0.0069
2853	14 kDa fatty acid-binding protein	Not Available	0.0068
505	Glutamate [NMDA] receptor subunit epsilon-3	GRIN2C	0.0068
162	Retinoic acid receptor gamma-1	RARG	0.0068
16	Adenosine A1 receptor	ADORA1	0.0068
3086	Plasmepsin-2	Not Available	0.0068
106	Cannabinoid receptor 2	CNR2	0.0068
1483	Membrane copper amine oxidase	AOC3	0.0067
3560	Gentamicin 3'-acetyltransferase	aacC1	0.0067
4311	tRNA	TRDMT1	0.0067
4325	tRNA	trmD	0.0067
4328	tRNA	trmD	0.0067
36	Insulin receptor	INSR	0.0066
389	Amiloride-sensitive cation channel 2, neuronal	ACCN2	0.0066
175	Thiamin pyrophosphokinase 1	TPK1	0.0066
164	Histamine H4 receptor	HRH4	0.0065
2287	Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase	ATIC	0.0064
936	Ephrin type-A receptor 2	EPHA2	0.0063
3601	Dihydropteroate synthase 1	folP1	0.0063
3807	Dihydropteroate synthase 1	folP1	0.0063
3808	Dihydropteroate synthase 2	folP2	0.0063
2417	Chloramphenicol acetyltransferase	cat	0.0063
3278	Chloramphenicol acetyltransferase	cat	0.0063
3432	Multidrug-efflux transporter 1 regulator	bmrR	0.0063
4476	Mannitol dehydrogenase	mtlD	0.0063
4217	Telomerase reverse transcriptase	TERT	0.0063
1119	Peroxiredoxin-5, mitochondrial	PRDX5	0.0063
133	Dihydropterate synthase	sulI	0.0063
281	5'-AMP-activated protein kinase subunit beta-1	PRKAB1	0.0063
3270	Elongation factor G	fusA	0.0062
2810	Dr hemagglutinin structural subunit	draA	0.0062
6105	3-oxo-5-beta-steroid 4-dehydrogenase	AKR1D1	0.0062
3802	Sodium channel protein type 2 subunit alpha	SCN2A	0.0062
2718	Chloramphenicol 3-O phosphotransferase	Not Available	0.0062
6501	Fatty acid-binding protein, liver	FABP1	0.0062
176	30S ribosomal protein S10	rpsJ	0.006
6175	30S ribosomal protein S10	rpsJ	0.006
6042	Prostaglandin reductase 2	PTGR2	0.006
4117	Probable pyruvate-flavodoxin oxidoreductase	ydbK	0.006
937	Proto-oncogene tyrosine-protein kinase LCK	LCK	0.006
6126	Carbonic anhydrase 7	CA7	0.006
518	Peroxidase/catalase T	katG	0.0059
3611	Cytidine deaminase	cdd	0.0059
3707	Cytidine deaminase	cdd	0.0059
4211	Cytidine deaminase	CDA	0.0059
1561	Troponin C, slow skeletal and cardiac muscles	TNNC1	0.0059
6103	Arylamine N-acetyltransferase 1	NAT1	0.0059
633	Penicillin-binding proteins 1A/1B	pbpA	0.0059
2232	Interleukin-5	IL5	0.0059
1593	Mucin-2	MUC2	0.0059
610	Calcium-activated potassium channel subunit alpha 1	KCNMA1	0.0059
4103	Proteasome subunit beta type 2	PSMB2	0.0059
4102	Proteasome subunit beta type 5	PSMB5	0.0059
215	Sodium channel protein type 11 subunit alpha	SCN11A	0.0059
4101	Proteasome subunit beta type 1	PSMB1	0.0059
1313	Lactoylglutathione lyase	GLO1	0.0059
3382	Glycolipid transfer protein	GLTP	0.0058
6824	Tyrosine-protein kinase Lyn	LYN	0.0058
3876	Aromatic-L-amino-acid decarboxylase	DDC	0.0058
773	Folylpolyglutamate synthase, mitochondrial	FPGS	0.0058
6344	ATP synthase subunit gamma, mitochondrial	ATP5C1	0.0057
6343	ATP synthase subunit beta, mitochondrial	ATP5B	0.0057
6342	ATP synthase subunit alpha, mitochondrial	ATP5A1	0.0057
267	Plasminogen activator inhibitor 1	SERPINE1	0.0057
685	Oxygen-insensitive NADPH nitroreductase	nfsA	0.0057
6945	Oxygen-insensitive NADPH nitroreductase	rdxA	0.0057
200	Carnitine O-palmitoyltransferase 2, mitochondrial	CPT2	0.0056
451	Carnitine O-palmitoyltransferase I, liver isoform	CPT1A	0.0056
6164	POU domain, class 5, transcription factor 1	POU5F1	0.0056
2391	Ferrochelatase	hemH	0.0056
6502	Ferrochelatase	DKFZp686P18130	0.0056
1591	Ferrochelatase, mitochondrial	FECH	0.0056
6506	Stathmin-4	STMN4	0.0055
1275	Estrogen sulfotransferase	SULT1E1	0.0054
280	4-aminobutyrate aminotransferase, mitochondrial	ABAT	0.0054
933	Proto-oncogene tyrosine-protein kinase Src	SRC	0.0053
6100	BDNF/NT-3 growth factors receptor	NTRK2	0.0053
2216	Fibroblast growth factor receptor 4	FGFR4	0.0053
137	FolC bifunctional protein [Includes: Folylpolyglutamate synthase	folC	0.0052
6172	ATP-binding cassette sub-family B member 8, mitochondrial	ABCB8	0.0052
2300	Lysozyme	E	0.0052
3633	Lysozyme	R	0.0052
5597	Lysozyme	17	0.0052
3913	Glutamic acid decarboxylase	GAD65	0.0052
6270	Group IIE secretory phospholipase A2	PLA2G2E	0.0051
66	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II	HSD3B2	0.0051
694	Matrix protein 2	M	0.0051
887	DNA gyrase subunit B	gyrB	0.0051
4150	DNA gyrase subunit B	gyrB	0.0051
6225	DNA gyrase subunit B	gyrB	0.0051
6046	Voltage-gated calcium channel beta 1 subunit splice variant CavB1d	CACNB1	0.0051
6221	Steroid hormone receptor ERR1	ESRRA	0.0051
1714	Mitogen-activated protein kinase 3	MAPK3	0.0051
65	Matrix metalloproteinase-9	Not Available	0.0051
1792	Tissue-type plasminogen activator	PLAT	0.0051
1341	Histamine H3 receptor	HRH3	0.0051
2616	Ganglioside GM2 activator	GM2A	0.0051
2499	Tubulin beta-2C chain	TUBB2C	0.0051
6259	(3R)-hydroxymyristoyl-acyl carrier protein dehydratase	fabZ	0.005
4199	Sphingosine 1-phosphate receptor Edg-8	S1PR5	0.005
541	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	PDE4B	0.005
6228	Nuclear receptor coactivator 1	NCOA1	0.005
2320	Thymidine kinase, cytosolic	TK1	0.005
6027	Alkaline phosphatase, tissue-nonspecific isozyme	ALPL	0.005
6048	Troponin C, skeletal muscle	TNNC2	0.005
1123	Eosinophil cationic protein	RNASE3	0.0049
229	Retinoic acid receptor beta	RARB	0.0049
1360	Sphingomyelin phosphodiesterase	SMPD1	0.0049
173	Toll-like receptor 7	TLR7	0.0049
6111	DNA polymerase epsilon subunit 4	POLE4	0.0049
6112	DNA polymerase epsilon subunit 3	POLE3	0.0048
6108	Ribonucleoside-diphosphate reductase subunit M2 B	RRM2B	0.0048
6110	DNA polymerase epsilon subunit 2	POLE2	0.0048
6109	DNA polymerase epsilon catalytic subunit A	POLE	0.0048
2347	Proto-oncogene serine/threonine-protein kinase Pim-1	PIM1	0.0048
6184	D-alanyl-D-alanine carboxypeptidase dacC	dacC	0.0048
760	Fibroblast growth factor 1	FGF1	0.0048
6495	Cytochrome c oxidase subunit 7C, mitochondrial	COX7C	0.0048
6493	Cytochrome c oxidase subunit 6C	COX6C	0.0048
6499	Cytochrome c oxidase polypeptide 7A1, mitochondrial	COX7A1	0.0048
6496	Cytochrome c oxidase subunit 8A, mitochondrial	COX8A	0.0048
6497	Cytochrome c oxidase subunit 6A2, mitochondrial	COX6A2	0.0048
6498	Cytochrome c oxidase subunit 6B1	COX6B1	0.0048
6494	Cytochrome c oxidase subunit 7B, mitochondrial	COX7B	0.0048
6491	Cytochrome c oxidase subunit 5A, mitochondrial	COX5A	0.0048
6489	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	COX4I1	0.0048
5793	Cytochrome c oxidase subunit 2	MT-CO2	0.0048
6559	Cytochrome c oxidase subunit 2	ctaC	0.0048
6669	Cytochrome c oxidase subunit 2	ctaC	0.0048
6490	Cytochrome c oxidase subunit 3	MT-CO3	0.0048
371	Cytochrome c oxidase subunit 1	MT-CO1	0.0048
6558	Cytochrome c oxidase subunit 1	ctaD	0.0048
730	Retinoic acid receptor alpha	RARA	0.0048
6677	Myelin P2 protein	PMP2	0.0047
6241	Nuclear receptor coactivator 2	NCOA2	0.0047
683	Potassium transporter	GK0582	0.0047
1759	85 kDa calcium-independent phospholipase A2	PLA2G6	0.0046
1770	Phospholipase C	PLCL1	0.0046
2841	Phospholipase C	plc	0.0046
565	Extracellular calcium-sensing receptor	CASR	0.0046
1648	Elastin	ELN	0.0046
3639	Thymidine phosphorylase	deoA	0.0046
3936	Thymidine phosphorylase	TYMP	0.0046
527	Prostacyclin receptor	PTGIR	0.0045
515	26S proteasome non-ATPase regulatory subunit 1	PSMD1	0.0045
522	26S proteasome non-ATPase regulatory subunit 2	PSMD2	0.0045
303	Diamine acetyltransferase 2	SAT2	0.0045
623	Spermine oxidase	SMOX	0.0045
1317	Spermine synthase	SMS	0.0045
4226	Uridine phosphorylase 2	UPP2	0.0045
1302	Dihydropyrimidine dehydrogenase [NADP+]	DPYD	0.0045
115	Penicillin-binding protein 2	mrdA	0.0044
6069	Penicillin-binding protein 2	mrdA	0.0044
6118	Penicillin-binding protein 2	penA	0.0044
6187	Penicillin-binding protein 2	pbpA	0.0044
6686	Penicillin-binding protein 2	pbp2	0.0044
6939	Penicillin-binding protein 2	mrdA	0.0044
7163	Penicillin-binding protein 2	pbpA	0.0044
337	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial	NDUFS7	0.0044
214	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	NDUFS3	0.0044
803	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	NDUFS2	0.0044
2540	Choloylglycine hydrolase	cbh	0.0044
130	Prostacyclin synthase	PTGIS	0.0044
2178	Metabotropic glutamate receptor 5	GRM5	0.0044
517	Alcohol dehydrogenase 1C	ADH1C	0.0044
5645	DNA topoisomerase 4 subunit B	parE	0.0044
6227	DNA topoisomerase 4 subunit B	parE	0.0044
707	72 kDa type IV collagenase	MMP2	0.0044
243	Ribosyldihydronicotinamide dehydrogenase [quinone]	NQO2	0.0043
3904	Alanine aminotransferase 2	GPT2	0.0043
735	Alanine aminotransferase 1	GPT	0.0043
3755	Nucleoside-specific channel-forming protein tsx precursor	tsx	0.0043
4218	Ribonucleoside-diphosphate reductase M2 subunit	RRM2	0.0043
6861	Alcohol dehydrogenase [NADP+]	AKR1A1	0.0043
476	RAC-alpha serine/threonine-protein kinase	AKT1	0.0042
1830	5'-nucleotidase	NT5E	0.0042
484	Tyrosine-protein kinase ABL2	ABL2	0.0042
4225	Uridine phosphorylase 1	UPP1	0.0042
6080	Neuronal acetylcholine receptor subunit alpha-5	CHRNA5	0.0041
6082	Neuronal acetylcholine receptor subunit beta-3	CHRNB3	0.0041
948	Neuronal acetylcholine receptor subunit beta-2	CHRNB2	0.0041
6068	Guanylate cyclase soluble subunit alpha-2	GUCY1A2	0.0041
1569	G1/S-specific cyclin-D1	CCND1	0.0041
6070	Nischarin	NISCH	0.0041
125	DNA polymerase beta	POLB	0.0041
5798	Mitogen-activated protein kinase 11	MAPK11	0.0041
828	Phenylalanine-4-hydroxylase	PAH	0.0041
3109	Phenylalanine-4-hydroxylase	phhA	0.0041
3997	Cytochrome P450 24A1, mitochondrial	CYP24A1	0.0041
123	Diamine acetyltransferase 1	SAT1	0.004
1064	DNA (cytosine-5)-methyltransferase 1	DNMT1	0.004
276	Sodium- and chloride-dependent GABA transporter 1	SLC6A1	0.004
6508	Putative uncharacterized protein	srtB	0.004
6543	Putative uncharacterized protein	tcp14	0.004
6615	Putative uncharacterized protein	MT0785	0.004
6623	Putative uncharacterized protein	Not Available	0.004
6806	Putative uncharacterized protein	AGR_C_2535	0.004
6813	Putative uncharacterized protein	SAV4671	0.004
6815	Putative uncharacterized protein	AFE_1514	0.004
6819	Putative uncharacterized protein	RUMGNA_03254	0.004
6825	Putative uncharacterized protein	CV_3270	0.004
4161	Furin	FURIN	0.004
291	Nitric-oxide synthase, endothelial	NOS3	0.004
2268	Cholesterol oxidase	choB	0.0039
2822	Cholesterol oxidase	choA	0.0039
741	Potassium voltage-gated channel subfamily KQT member 1	KCNQ1	0.0039
4162	Potassium voltage-gated channel subfamily KQT member 3	KCNQ3	0.0039
1129	C-C chemokine receptor type 5	CCR5	0.0039
564	Cellular retinoic acid-binding protein 1	CRABP1	0.0038
6067	Penicillin binding protein 2a	mecA	0.0038
413	Amidophosphoribosyltransferase	PPAT	0.0038
2515	Amidophosphoribosyltransferase	purF	0.0038
3714	Amidophosphoribosyltransferase	purF	0.0038
6081	Neuronal acetylcholine receptor subunit alpha-6	CHRNA6	0.0038
2472	Voltage-gated potassium channel	kcsA	0.0038
6366	Voltage-gated potassium channel	kcsA	0.0038
719	Retinoic acid receptor responder protein 1	RARRES1	0.0038
770	Retinoic acid-induced protein 3	GPRC5A	0.0038
233	Potassium channel subfamily K member 2	KCNK2	0.0038
85	Growth hormone receptor	GHR	0.0038
1063	Signal transducer and activator of transcription 5B	STAT5B	0.0037
935	Proto-oncogene tyrosine-protein kinase Yes	YES1	0.0037
859	Cellular retinoic acid-binding protein 2	CRABP2	0.0037
3426	Glutamine synthetase	glnA	0.0037
3987	Glutamine synthetase	GLUL	0.0037
368	Enoyl-[acyl-carrier-protein] reductase [NADH]	inhA	0.0037
3228	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0037
3678	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0037
6856	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0037
2283	Steroid Delta-isomerase	ksi	0.0037
2920	Steroid Delta-isomerase	ksi	0.0037
2207	Rhodopsin	RHO	0.0036
3616	Fatty acid-binding protein, epidermal	FABP5	0.0036
5431	Lipid binding protein	Not Available	0.0036
5433	UPF0230 protein TM_1468	TM_1468	0.0036
5430	Hepatocyte nuclear factor 4-gamma	HNF4G	0.0036
819	Penicillin-binding protein 4	dacB	0.0036
1262	Corticotropin-lipotropin	POMC	0.0035
939	50S ribosomal protein L3	rplC	0.0035
6500	Phospholipase A2	PLA2G1B	0.0034
2325	Sulfotransferase family cytosolic 2B member 1	SULT2B1	0.0034
1971	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	PDE4A	0.0034
934	Proto-oncogene tyrosine-protein kinase Fyn	FYN	0.0033
3937	Fatty-acid amide hydrolase	FAAH	0.0033
569	Retinal dehydrogenase 2	ALDH1A2	0.0033
6459	Glycodelin	PAEP	0.0033
5432	Trafficking protein particle complex subunit 3	TRAPPC3	0.0033
76	Nitric-oxide synthase, brain	NOS1	0.0033
2251	Thymidylate kinase	tmk	0.0033
2254	Thymidylate kinase	DTYMK	0.0033
3522	Thymidylate kinase	tmk	0.0033
3478	Glucose-1-phosphate thymidylyltransferase	rmlA	0.0032
4277	Glucose-1-phosphate thymidylyltransferase	rmlA	0.0032
1867	Major prion protein	PRNP	0.0032
2107	Microtubule-associated protein 1A	MAP1A	0.0032
595	Fibrinogen alpha chain	FGA	0.0032
140	30S ribosomal protein S9	rpsI	0.0031
6719	30S ribosomal protein S9	rpsI	0.0031
6725	30S ribosomal protein S9	rpsI	0.0031
2257	Uridine phosphorylase	udp	0.0031
5132	Uridine phosphorylase	udp	0.0031
449	Ornithine decarboxylase	ODC1	0.0031
1636	Trace amine-associated receptor 1	TAAR1	0.0031
611	Retinal dehydrogenase 1	ALDH1A1	0.0031
1227	Cytochrome b	MT-CYB	0.0031
6386	Cytochrome b	petB	0.0031
6937	Cytochrome b	MT-CYB	0.0031
674	Dihydroorotate dehydrogenase homolog, mitochondrial	PFF0160c	0.0031
3760	Penicillin-binding protein 5 precursor	dacA	0.0031
2578	Tubulin beta-3 chain	TUBB3	0.003
2285	Streptogramin A acetyltransferase	vatD	0.003
283	SEC14-like protein 2	SEC14L2	0.003
749	Amiloride-sensitive cation channel 1, neuronal	ACCN1	0.003
636	Mitochondrial carnitine/acylcarnitine carrier protein	SLC25A20	0.0029
109	Mitochondrial carnitine/acylcarnitine carrier protein CACL	SLC25A29	0.0029
3813	Fibrinogen gamma chain	FGG	0.0029
3812	Fibrinogen beta chain [Contains: Fibrinopeptide B]	FGB	0.0029
5126	Arginase	rocF	0.0029
3950	Cell division protein kinase 9	CDK9	0.0029
3968	Cell division protein kinase 8	CDK8	0.0029
277	Purine nucleoside phosphorylase	PNP	0.0029
2870	Purine nucleoside phosphorylase	punA	0.0029
2945	Purine nucleoside phosphorylase	punA	0.0029
4659	Purine nucleoside phosphorylase	TM_1596	0.0029
4825	Purine nucleoside phosphorylase	TTHA1435	0.0029
663	Solute carrier family 12 member 4	SLC12A4	0.0029
53	Solute carrier family 12 member 5	SLC12A5	0.0029
605	Fumarate reductase flavoprotein subunit	frdA	0.0028
2709	Fumarate reductase flavoprotein subunit	SO_0970	0.0028
3673	Fumarate reductase flavoprotein subunit	fccA	0.0028
4912	Fumarate reductase flavoprotein subunit	ifcA	0.0028
6549	Fumarate reductase flavoprotein subunit	frdA	0.0028
6207	30S ribosomal protein S14	rpsN	0.0028
6209	30S ribosomal protein S19	rpsS	0.0028
6712	30S ribosomal protein S19	rpsS	0.0028
6726	30S ribosomal protein S19	rpsS	0.0028
1278	Pro-epidermal growth factor	EGF	0.0028
1200	AMBP protein	AMBP	0.0028
3866	Serum amyloid A protein	SAA1	0.0028
1932	Apolipoprotein E	APOE	0.0028
1176	Mitogen-activated protein kinase 1	MAPK1	0.0027
387	Amiloride-sensitive amine oxidase [copper-containing]	ABP1	0.0027
7187	Amiloride-sensitive amine oxidase [copper-containing]	ABP1	0.0027
6232	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	GNAS	0.0027
6233	Adenylate cyclase type 2	ADCY2	0.0027
6234	Adenylate cyclase type 5	ADCY5	0.0027
1144	Hepatocyte growth factor receptor	MET	0.0027
4173	Tyrosine-protein kinase JAK2	JAK2	0.0027
2159	Quinone oxidoreductase	CRYZ	0.0027
827	Sodium/hydrogen exchanger 1	SLC9A1	0.0027
144	Hemoglobin subunit alpha	HBA1	0.0027
889	3-oxoacyl-[acyl-carrier-protein] synthase 1	fabB	0.0027
6860	3-oxoacyl-[acyl-carrier-protein] synthase 1	kasA	0.0027
310	Solute carrier family 12 member 2	SLC12A2	0.0027
4228	Keratin, type II cytoskeletal 7	KRT7	0.0027
213	Amiloride-sensitive sodium channel subunit alpha	SCNN1A	0.0026
550	Amiloride-sensitive sodium channel subunit delta	SCNN1D	0.0026
27	Amiloride-sensitive sodium channel subunit beta	SCNN1B	0.0026
552	Amiloride-sensitive sodium channel subunit gamma	SCNN1G	0.0026
382	Glutamate receptor, ionotropic kainate 1	GRIK1	0.0026
5997	Tumor necrosis factor ligand superfamily member 11	TNFSF11	0.0026
804	Mitochondrial folate transporter/carrier	SLC25A32	0.0026
718	Folate receptor gamma	FOLR3	0.0026
299	Folate receptor beta	FOLR2	0.0026
1039	Histone deacetylase 9	HDAC9	0.0026
412	Peroxisomal carnitine O-octanoyltransferase	CROT	0.0026
551	Carnitine O-acetyltransferase	CRAT	0.0025
3959	Cell division protein kinase 4	CDK4	0.0025
1385	Angiotensin-converting enzyme 2	ACE2	0.0025
4252	Penicillin-binding protein 5	dacA	0.0025
734	D1 dopamine receptor-interacting protein calcyon	CALY	0.0025
3482	Cell division protein kinase 7	CDK7	0.0025
3957	Adenosine deaminase	ADA	0.0024
4041	Microsomal glutathione S-transferase 2	MGST2	0.0024
544	Potassium voltage-gated channel subfamily E member 1	KCNE1	0.0024
5878	Alpha-7 nicotinic cholinergic receptor subunit	CHRFAM7A	0.0024
159	Penicillin-binding protein 2B	penA	0.0024
6121	Penicillin-binding protein 2B	penA	0.0024
6039	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	PDE11A	0.0024
6231	Pepsin A	PGA3	0.0024
5852	Type-2 angiotensin II receptor	AGTR2	0.0024
1374	Natriuretic peptides B	NPPB	0.0024
1827	Gap junction alpha-1 protein	GJA1	0.0024
1908	Vascular cell adhesion protein 1	VCAM1	0.0023
3955	Cell division protein kinase 6	CDK6	0.0023
4221	Vascular endothelial growth factor	VEGF	0.0023
624	Guanidinoacetate N-methyltransferase	GAMT	0.0023
5816	Cadherin-5	CDH5	0.0023
332	Beta-lactamase	blaZ	0.0023
2478	Beta-lactamase	ampC	0.0023
2613	Beta-lactamase	ampC	0.0023
2635	Beta-lactamase	ampC	0.0023
2700	Beta-lactamase	penP	0.0023
5445	Beta-lactamase	blaB	0.0023
6019	Beta-lactamase	SHV-7	0.0023
6701	Beta-lactamase	cphA	0.0023
2240	Cell division protein kinase 2	CDK2	0.0023
268	Adenosine A2b receptor	ADORA2B	0.0023
182	2-oxoglutarate dehydrogenase E1 component, mitochondrial	OGDH	0.0022
630	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial	ACADSB	0.0022
6931	Calcium-activated potassium channel subunit beta-1	KCNMB1	0.0022
6933	Calcium-activated potassium channel subunit beta-4	KCNMB4	0.0022
6932	Calcium-activated potassium channel subunit beta-3	KCNMB3	0.0022
6934	Small conductance calcium-activated potassium channel protein 1	KCNN1	0.0022
6935	Small conductance calcium-activated potassium channel protein 2	KCNN2	0.0022
6936	Small conductance calcium-activated potassium channel protein 3	KCNN3	0.0022
695	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	PDE10A	0.0022
3404	Exotoxin A	eta	0.0022
298	Renin	REN	0.0021
63	Malate dehydrogenase	mdh	0.0021
2329	Malate dehydrogenase	mdh	0.0021
3445	Malate dehydrogenase	mdh	0.0021
4420	Malate dehydrogenase	mdh	0.0021
4438	Malate dehydrogenase	mdh	0.0021
331	Retinol-binding protein I, cellular	RBP1	0.0021
1768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit	GNG2	0.0021
1268	Neuropeptide S receptor	NPSR1	0.002
1581	G protein-activated inward rectifier potassium channel 2	KCNJ6	0.002
1571	G protein-activated inward rectifier potassium channel 1	KCNJ3	0.002
591	Glutamate [NMDA] receptor subunit 3B	GRIN3B	0.002
3090	Chitosanase	csn	0.002
4149	Nuclear factor NF-kappa-B p100 subunit	NFKB2	0.002
1742	D-HSCDK2	CDK2deltaT	0.002
1771	Cell division control protein 2 homolog	CDK1	0.002
3321	Cell division control protein 2 homolog	CRK2	0.002
194	NADH dehydrogenase [ubiquinone] 1 subunit C2	NDUFC2	0.002
6893	Calcium/calmodulin-dependent protein kinase type II gamma chain	CAMK2G	0.002
6755	Poliovirus receptor	PVR	0.002
1058	Cell division protein kinase 5	CDK5	0.002
5463	Calcium-activated potassium channel subunit beta 2	KCNMB2	0.002
4031	Glutathione S-transferase A1	GSTA1	0.0019
170	Succinate semialdehyde dehydrogenase, mitochondrial	ALDH5A1	0.0019
5766	NAD-dependent deacetylase sirtuin-5	SIRT5	0.0019
444	Alcohol dehydrogenase 1B	ADH1B	0.0019
473	L-lactate dehydrogenase A chain	LDHA	0.0019
1638	Solute carrier family 2, facilitated glucose transporter member 2	SLC2A2	0.0019
6073	Potassium channel subfamily K member 9	KCNK9	0.0019
6072	Potassium channel subfamily K member 3	KCNK3	0.0019
893	[Citrate [pro-3S]-lyase] ligase	citC	0.0018
845	Pyruvate dehydrogenase [cytochrome]	poxB	0.0018
1253	Interferon gamma	IFNG	0.0018
5998	Toll-like receptor 8	TLR8	0.0018
3920	Methylenetetrahydrofolate reductase intermediate form	MTHFR	0.0018
3763	5,10-methylenetetrahydrofolate reductase	metF	0.0018
3918	5,10-methylenetetrahydrofolate reductase	MTHFR	0.0018
5094	5,10-methylenetetrahydrofolate reductase	metF	0.0018
59	AMT protein	AMT	0.0018
3919	Methionyl-tRNA formyltransferase, mitochondrial	MTFMT	0.0018
1202	10-formyltetrahydrofolate dehydrogenase	ALDH1L1	0.0018
712	Tubulin alpha chain	TUB1	0.0018
1968	ATP-sensitive inward rectifier potassium channel 12	KCNJ12	0.0018
327	Glutathione reductase	gor	0.0018
5110	Glutathione reductase	GR2	0.0018
3312	Fatty acid-binding protein, brain	FABP7	0.0018
1198	Serum paraoxonase/arylesterase 1	PON1	0.0018
6223	Penicillin-binding protein 1C	pbpC	0.0018
67	Prolyl 4-hydroxylase subunit alpha-1	P4HA1	0.0017
613	Atrial natriuretic peptide receptor A	NPR1	0.0017
251	Alcohol dehydrogenase 1A	ADH1A	0.0017
2290	ADP-ribosyl cyclase 2	BST1	0.0017
4043	Glutaredoxin-2, mitochondrial	GLRX2	0.0017
1928	Leukotriene C4 synthase	LTC4S	0.0017
4034	Glutaredoxin-1	GLRX	0.0017
910	Epididymal secretory glutathione peroxidase	GPX5	0.0017
4037	Hypothetical protein	GPX1	0.0017
4297	Hypothetical protein	SP_1951	0.0017
4521	Hypothetical protein	BC_2969	0.0017
4540	Hypothetical protein	TM_1070	0.0017
4555	Hypothetical protein	MT1739	0.0017
4569	Hypothetical protein	mshD	0.0017
4578	Hypothetical protein	PA3270	0.0017
4747	Hypothetical protein	PA3967	0.0017
5177	Hypothetical protein	TM_0096	0.0017
5194	Hypothetical protein	PA1204	0.0017
5240	Hypothetical protein	Rv2991	0.0017
5370	Hypothetical protein	TM_1158	0.0017
5710	Hypothetical protein	Tb927.5.1360	0.0017
4029	Microsomal glutathione S-transferase 3	MGST3	0.0017
4036	Glutathione peroxidase 6	GPX6	0.0017
4030	Thioredoxin domain-containing protein 12	TXNDC12	0.0017
4032	Microsomal glutathione S-transferase 1	MGST1	0.0017
903	Glutathione S-transferase A5	GSTA5	0.0017
4040	Glutathione peroxidase 7	GPX7	0.0017
907	Glutathione peroxidase 2	GPX2	0.0017
900	Glutathione S-transferase A4	GSTA4	0.0017
911	Glutathione peroxidase 3	GPX3	0.0017
906	Glutathione peroxidase 1	GPX1	0.0017
4039	CDNA FLJ23636 fis, clone CAS07176	GPX8	0.0017
4035	Glutathione S-transferase Mu 5	GSTM5	0.0017
4042	Glutathione transferase omega-2	GSTO2	0.0017
4038	Glutathione peroxidase 4	GPX4	0.0017
1975	Phospholipid hydroperoxide glutathione peroxidase, mitochondrial	GPX4	0.0017
4033	S-formylglutathione hydrolase	ESD	0.0017
1056	Gamma-glutamyltranspeptidase 1	GGT1	0.0017
3830	Calreticulin	CALR	0.0017
5682	Ribonuclease pancreatic	RNASE1	0.0017
1074	Urokinase-type plasminogen activator	PLAU	0.0017
3929	Phosphoethanolamine/phosphocholine phosphatase	PHOSPHO1	0.0016
264	Choline/ethanolamine kinase [Includes: Choline kinase beta	CHKB	0.0016
3933	Choline/ethanolaminephosphotransferase	CEPT1	0.0016
1686	Choline transporter-like protein 1	SLC44A1	0.0016
3926	Choline transporter-like protein 2	SLC44A2	0.0016
861	Choline kinase alpha	CHKA	0.0016
3927	Choline transporter-like protein 3	SLC44A3	0.0016
769	High-affinity choline transporter 1	SLC5A7	0.0016
700	Choline dehydrogenase, mitochondrial	CHDH	0.0016
549	Choline-phosphate cytidylyltransferase B	PCYT1B	0.0016
3925	Choline transporter-like protein 4	SLC44A4	0.0016
576	Choline O-acetyltransferase	CHAT	0.0016
3922	Phospholipase D2	PLD2	0.0016
6123	Carbonic anhydrase 5A, mitochondrial	CA5A	0.0016
3924	Phospholipase D1	PLD1	0.0016
820	Glycine receptor subunit alpha-2	GLRA2	0.0016
6766	O-GlcNAcase BT_4395	BT_4395	0.0016
2297	Genome polyprotein	Not Available	0.0016
2322	Genome polyprotein	Not Available	0.0016
2694	Genome polyprotein	Not Available	0.0016
2719	Genome polyprotein	Not Available	0.0016
2860	Genome polyprotein	Not Available	0.0016
2928	Genome polyprotein	Not Available	0.0016
3160	Genome polyprotein	Not Available	0.0016
3260	Genome polyprotein	Not Available	0.0016
4783	Genome polyprotein	Not Available	0.0016
5726	Genome polyprotein	Not Available	0.0016
5779	Genome polyprotein	Not Available	0.0016
5867	Genome polyprotein	Not Available	0.0016
6253	Genome polyprotein	Not Available	0.0016
6301	Genome polyprotein	Not Available	0.0016
6380	Genome polyprotein	Not Available	0.0016
6381	Genome polyprotein	Not Available	0.0016
6437	Genome polyprotein	Not Available	0.0016
6520	Genome polyprotein	Not Available	0.0016
6521	Genome polyprotein	Not Available	0.0016
6652	Genome polyprotein	Not Available	0.0016
6734	Genome polyprotein	Not Available	0.0016
6735	Genome polyprotein	Not Available	0.0016
6736	Genome polyprotein	Not Available	0.0016
6737	Genome polyprotein	Not Available	0.0016
6738	Genome polyprotein	Not Available	0.0016
6739	Genome polyprotein	Not Available	0.0016
6744	Genome polyprotein	Not Available	0.0016
6748	Genome polyprotein	Not Available	0.0016
6894	Genome polyprotein	Not Available	0.0016
6898	Genome polyprotein	Not Available	0.0016
6034	Hydroxyindole O-methyltransferase	ASMT	0.0016
6035	Nuclear receptor ROR-beta	RORB	0.0016
3319	Hydroxyacylglutathione hydrolase	HAGH	0.0016
6036	Eosinophil peroxidase	EPX	0.0016
898	Glutathione S-transferase A3	GSTA3	0.0016
897	Glutathione S-transferase kappa 1	GSTK1	0.0015
3233	Bile acid receptor	NR1H4	0.0015
296	Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial	MTHFD2	0.0015
909	Maleylacetoacetate isomerase	GSTZ1	0.0015
3126	Poly [ADP-ribose] polymerase 1	PARP1	0.0015
982	Cocaine- and amphetamine-regulated transcript protein	CARTPT	0.0015
2101	Glutathione-requiring prostaglandin D synthase	HPGDS	0.0015
899	Glutathione S-transferase Mu 3	GSTM3	0.0015
905	Glutathione transferase omega-1	GSTO1	0.0015
340	Apoptotic protease-activating factor 1	APAF1	0.0015
3884	SHMT2 protein	SHMT2	0.0014
3901	SHMT2 protein	SHMT2	0.0014
3885	Hypothetical protein DKFZp686P09201	DKFZp686P09201	0.0014
3879	Serine hydroxymethyltransferase 2	Not Available	0.0014
321	Serine hydroxymethyltransferase, mitochondrial	SHMT2	0.0014
2129	Sucrase-isomaltase, intestinal	SI	0.0014
6032	PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE)	fas	0.0014
2165	Glutathione S-transferase Mu 2	GSTM2	0.0014
3221	Cytochrome c4	cc4	0.0014
914	Formimidoyltransferase-cyclodeaminase	FTCD	0.0014
765	Indoleamine 2,3-dioxygenase	IDO1	0.0014
679	C-1-tetrahydrofolate synthase, cytoplasmic	MTHFD1	0.0013
207	Glutathione synthetase	GSS	0.0013
5269	Glutathione synthetase	gshB	0.0013
809	Methionine synthase	MTR	0.0013
2935	Methionine synthase	metH	0.0013
825	Arsenical pump-driving ATPase	ASNA1	0.0013
3435	Arsenical pump-driving ATPase	arsA	0.0013
486	Serine/threonine-protein kinase ALS2CR7	CDK15	0.0013
510	Serine/threonine-protein kinase receptor R3	ACVRL1	0.0013
2105	ATP-binding cassette sub-family G member 1	ABCG1	0.0013
745	Anti-Muellerian hormone type-2 receptor	AMHR2	0.0013
483	A-Raf proto-oncogene serine/threonine-protein kinase	ARAF	0.0013
733	Activin receptor type 1B	ACVR1B	0.0013
225	NEDD8-activating enzyme E1 regulatory subunit	NAE1	0.0013
154	AFG3-like protein 2	AFG3L2	0.0013
377	Beta-adrenergic receptor kinase 1	ADRBK1	0.0013
21	Beta-adrenergic receptor kinase 2	ADRBK2	0.0013
395	ALK tyrosine kinase receptor	Not Available	0.0013
1152	Glycogen phosphorylase, muscle form	PYGM	0.0013
901	Glutathione S-transferase Mu 4	GSTM4	0.0013
6131	Carbonic anhydrase 14	CA14	0.0013
860	Nicotinamide N-methyltransferase	NNMT	0.0013
699	Nicotinic acid receptor 1	GPR109A	0.0013
928	Nicotinic acid receptor 2	GPR109B	0.0013
583	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	QPRT	0.0013
2442	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	nadC	0.0013
2459	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	nadC	0.0013
1405	Thiopurine S-methyltransferase	TPMT	0.0013
6116	Gastric triacylglycerol lipase	LIPF	0.0012
822	Aldose reductase	AKR1B1	0.0012
367	Serine hydroxymethyltransferase, cytosolic	SHMT1	0.0012
3806	cGMP-dependent 3',5'-cyclic phosphodiesterase	PDE2A	0.0012
3823	Cytokine receptor common gamma chain	IL2RG	0.0012
292	Activin receptor type-1	ACVR1	0.0012
6122	Carbonic anhydrase 3	CA3	0.0012
1295	Fatty acid synthase	FASN	0.0012
849	Activated CDC42 kinase 1	TNK2	0.0012
4948	Cytochrome c-553	Not Available	0.0012
4923	Cytochrome c3	DvMF_2499	0.0012
4945	Cytochrome c3	Not Available	0.0012
4949	Cytochrome c3	DVU_3171	0.0012
4968	Cytochrome c3	cytc3	0.0012
4997	Cytochrome c3	SO_2727	0.0012
5219	Cytochrome c3	cyd	0.0012
4902	Nine-heme cytochrome c	Ddes_2038	0.0012
3189	High-molecular-weight cytochrome c	hmcA	0.0012
6859	Protein S100-A4	S100A4	0.0012
704	Long-chain-fatty-acid--CoA ligase 1	ACSL1	0.0011
821	Acetyl-coenzyme A synthetase 2-like, mitochondrial	ACSS1	0.0011
386	Acetyl-coenzyme A synthetase, cytoplasmic	ACSS2	0.0011
297	Adenylate cyclase type 1	ADCY1	0.0011
289	Cytosolic purine 5'-nucleotidase	NT5C2	0.0011
714	Glutathione reductase, mitochondrial	GSR	0.0011
754	Pancreatic triacylglycerol lipase	PNLIP	0.0011
724	Interleukin-2 receptor alpha chain	IL2RA	0.0011
717	Interleukin-2 receptor subunit beta	IL2RB	0.0011
1810	Protein S100-A1	S100A1	0.001
6097	Protein S100-A2	S100A2	0.001
2461	D-alanyl-D-alanine carboxypeptidase	Not Available	0.001
5756	D-alanyl-D-alanine carboxypeptidase	dac	0.001
4386	Hemoglobin-like protein HbN	glbN	0.001
493	25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	CYP27B1	0.001
512	DNA-directed RNA polymerase alpha chain	rpoA	0.001
5772	DNA-directed RNA polymerase alpha chain	rpoA	0.001
2473	Tyrosine-protein kinase CSK	CSK	0.001
2398	Tyrosine-protein kinase ZAP-70	ZAP70	0.001
740	Argininosuccinate synthase	ASS1	0.001
865	Argininosuccinate synthase	ASS1	0.001
2680	Argininosuccinate synthase	argG	0.001
3194	Argininosuccinate synthase	argG	0.001
2298	Cytochrome P450-cam	camC	0.001
661	ADP/ATP translocase 1	SLC25A4	0.0009
6021	Adenosine kinase	ADK	0.0009
242	Asparagine synthetase [glutamine-hydrolyzing]	ASNS	0.0009
1048	Protein S100-A13	S100A13	0.0009
2226	Protein S100-A12	S100A12	0.0009
390	Adenosine A3 receptor	ADORA3	0.0009
2132	Protein S100-B	S100B	0.0009
22	30S ribosomal protein S4	rpsD	0.0008
6714	30S ribosomal protein S4	rpsD	0.0008
4954	Soluble cytochrome b558	Not Available	0.0008
4943	Cytochrome c6	petJ	0.0008
4916	Cyanoglobin	glbN	0.0008
4947	Bacterial hemoglobin	vhb	0.0008
4934	Cytochrome c-551	nirM	0.0008
5218	Cytochrome c-551	nirM	0.0008
4915	Cytochrome c-550	psbV	0.0008
4959	Cytochrome c-550	psbV	0.0008
5216	Cytochrome c-550	psbV	0.0008
4925	Cytochrome c-type protein SHP	shp	0.0008
5000	HemO	hemO	0.0008
4975	Cytochrome c-556	RPA3973	0.0008
4936	Cytochrome c2 iso-2	Not Available	0.0008
4994	Hemoglobin-like protein HbO	glbO	0.0008
4905	Cytochrome c2	Not Available	0.0008
4939	Cytochrome c2	cycA	0.0008
4964	Cytochrome c2	cycA	0.0008
4979	Cytochrome c2	cycA	0.0008
6673	Cytochrome c2	cycA	0.0008
4942	Diheme cytochrome c napB	napB	0.0008
4984	Neuroglobin	NGB	0.0008
4981	Iron-starvation protein PigA	pigA	0.0008
4998	Hemoglobin-like protein yjbI	yjbI	0.0008
4935	Cytochrome c-554	cycA1	0.0008
4909	CooA protein	cooA	0.0008
4910	Cytoglobin	CYGB	0.0008
4961	Hemophore HasA	hasA	0.0008
4904	Cytochrome c family protein	GSU1996	0.0008
644	Heme oxygenase 2	HMOX2	0.0008
4982	Heme oxygenase 2	pbsA2	0.0008
4971	Nonaheme cytochrome c	hmcA	0.0008
4907	Cytochrome c-L	moxG	0.0008
6865	Cytochrome c-L	moxG	0.0008
4937	Cytochrome oxidase subunit II	rcoxA	0.0008
4989	Cytochrome c551 peroxidase	ccp	0.0008
5222	Cytochrome c551 peroxidase	ccpA	0.0008
4931	Cytochrome P450 167A1	CYP167A1	0.0008
4976	Apocytochrome f	petA	0.0008
6407	Apocytochrome f	petA	0.0008
4764	Cytochrome P450 165C4	CYP165C4	0.0008
4999	Cytochrome P450 165B3	CYP165B3	0.0008
4960	Putative cytochrome P450-family protein	SCO7417	0.0008
4903	Methyl-accepting chemotaxis protein	Tar4	0.0008
4922	Cytochrome c, putative	SO_4144	0.0008
4926	Heme-based aerotactic transducer hemAT	hemAT	0.0008
4970	Cytochrome c nitrite reductase catalytic subunit	nrfA	0.0008
4972	P450cin	cinA	0.0008
4993	Hydroxylamine oxidoreductase	hao1	0.0008
4952	Catalase/peroxidase	katA	0.0008
3093	Catalase HPII	katE	0.0008
4908	Heme-regulated cyclic AMP phosphodiesterase	dosP	0.0008
1507	Cytochrome c	CYCS	0.0008
500	Monocarboxylate transporter 4	SLC16A3	0.0008
1649	Small inducible cytokine A2	CCL2	0.0008
2530	Protein kinase C theta type	PRKCQ	0.0008
1025	Aquaporin-1	AQP1	0.0008
2091	Endoplasmin	HSP90B1	0.0008
866	Large neutral amino acids transporter small subunit 2	SLC7A8	0.0007
6316	ADP-ribosylation factor 1	ARF1	0.0007
6134	Sodium channel subunit beta-3	SCN3B	0.0007
6133	Sodium channel subunit beta-2	SCN2B	0.0007
6135	Sodium channel subunit beta-4	SCN4B	0.0007
6132	Sodium channel subunit beta-1	SCN1B	0.0007
6129	Carbonic anhydrase-related protein 11	CA11	0.0007
6127	Carbonic anhydrase-related protein	CA8	0.0007
6128	Carbonic anhydrase-related protein 10	CA10	0.0007
2408	Tyrosine-protein kinase SYK	SYK	0.0007
2511	MAP kinase-activated protein kinase 2	MAPKAPK2	0.0007
226	Gonadotropin-releasing hormone receptor	GNRHR	0.0007
3803	Sodium channel protein type 3 subunit alpha	SCN3A	0.0006
6130	Carbonic anhydrase 13	CA13	0.0006
6124	Carbonic anhydrase 5B, mitochondrial	CA5B	0.0006
4920	Peroxidase/catalase	katG	0.0006
2119	Cytochrome b5	CYB5A	0.0006
4990	PpcA	ppcA	0.0006
4956	Quinohemoprotein alcohol dehydrogenase ADH IIB	qbdA	0.0006
3375	Acidic cytochrome c3	Not Available	0.0006
4988	Sulfite oxidase, mitochondrial	SUOX	0.0006
2915	Sensor protein fixL	fixL	0.0006
4944	Sensor protein fixL	fixL	0.0006
3570	Cytochrome P450 152A1	cypC	0.0006
4813	Heme oxygenase	hmuO	0.0006
5769	Heme oxygenase	Not Available	0.0006
4385	Cytochrome c'	Not Available	0.0006
4967	Cytochrome c'	cycA	0.0006
5038	Cytochrome c'	Not Available	0.0006
5223	Cytochrome c'	cycP	0.0006
4289	Cytochrome P450	TT_P0059	0.0006
6262	Cytochrome P450	staP	0.0006
4992	Cytochrome c peroxidase	Not Available	0.0006
2230	Catalase	CAT	0.0006
3249	Catalase	katA	0.0006
3625	Catalase	katA	0.0006
4539	Catalase	katA	0.0006
4941	Catalase	katB	0.0006
5221	Cytochrome c3, 13 kDa	Not Available	0.0006
3152	Cytochrome c''	cycA	0.0006
5220	Split-Soret cytochrome c	Ddes_2150	0.0006
3700	Cytochrome c-552 precursor	nrfA	0.0006
1721	Glycogen synthase kinase-3 beta	GSK3B	0.0005
3238	Multidrug resistance protein mexA	mexA	0.0005
3116	Bacterioferritin	bfr	0.0005
4906	Bacterioferritin	bfr	0.0005
4965	Bacterioferritin	bfr	0.0005
3173	Enolase	eno	0.0005
3709	Glycerol uptake facilitator protein	glpF	0.0005
3336	C4-dicarboxylate transport transcriptional regulatory protein dctD	dctD	0.0005
3393	TGF-beta receptor type-2	TGFBR2	0.0005
5489	Ribonucleoside-diphosphate reductase 1 subunit beta	nrdB	0.0005
6743	Non-fluorescent flavoprotein	luxF	0.0005
6753	Apolipoprotein M	APOM	0.0005
2528	Fatty acid metabolism regulator protein	fadR	0.0005
6740	Fatty acid metabolism regulator protein	fadR	0.0005
6752	Guanylyl cyclase-activating protein 1	GUCA1A	0.0005
394	Calcineurin subunit B isoform 1	PPP3R1	0.0005
6742	Recoverin	RCVRN	0.0005
6747	Chalcone/stilbene synthase family protein	MT1417	0.0005
6741	Peroxisomal 3,2-trans-enoyl-CoA isomerase	PECI	0.0005
6522	Hepatocyte nuclear factor 4-alpha	HNF4A	0.0005
6751	Gag polyprotein	gag	0.0005
6746	Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	PPP3CA	0.0005
1939	Heat shock protein HSP 90-alpha	HSP90AA1	0.0005
6749	Polyprotein	Not Available	0.0005
3670	Soluble cytochrome b562 precursor	cybC	0.0005
3411	Cytochrome P450 121	cyp121	0.0005
3291	Cytochrome c-552	cycA	0.0005
4927	Cytochrome c-552	nrfA	0.0005
4938	Cytochrome c-552	cycA	0.0005
4953	Cytochrome c-552	nrfA	0.0005
5217	Cytochrome c-552	cycM	0.0005
2617	Nitric oxide synthase oxygenase	nos	0.0005
2701	Nitric oxide synthase oxygenase	nos	0.0005
3102	Flavohemoprotein	hmp	0.0005
4969	Flavohemoprotein	hmp	0.0005
3007	Carbonic anhydrase 12	CA12	0.0005
4205	Carbonic anhydrase 9	CA9	0.0005
3127	Nitrite reductase	nirS	0.0005
3284	Nitrite reductase	nirS	0.0005
2852	DNA mismatch repair protein mutL	mutL	0.0005
5961	Insulin	INS	0.0005
2236	Casein kinase II subunit alpha	CSNK2A1	0.0005
5278	Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1	PAPSS1	0.0005
2845	Bifunctional P-450:NADPH-P450 reductase	CYP102A1	0.0005
6527	Lymphocyte antigen 96	LY96	0.0005
3191	Histidinol dehydrogenase	hisD	0.0005
2972	6-deoxyerythronolide B hydroxylase	eryF	0.0005
4608	Putative cytochrome P450	SCO1207	0.0004
4963	Putative cytochrome P450	SCO2884	0.0004
6254	Putative cytochrome P450	SCO6998	0.0004
3405	Quinohaemoprotein ethanol dehydrogenase type-1	qheDH	0.0004
6750	ADP-ribosylation factor 6	ARF6	0.0004
4373	Medium-chain-fatty-acid--CoA ligase	Not Available	0.0004
4692	A/G-specific adenine glycosylase	mutY	0.0004
6524	Protein tonB	tonB	0.0004
358	Cystathionine beta-synthase	CBS	0.0004
2435	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase	lpxC	0.0004
6613	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase	lpxC	0.0004
693	Hemoglobin subunit beta	HBB	0.0004
2802	Endoglucanase G	celCCG	0.0004
6268	Hydroxyacid oxidase 1	HAO1	0.0004
810	Heme oxygenase 1	HMOX1	0.0004
3391	Heme oxygenase 1	pbsA1	0.0004
864	Gag-Pol polyprotein	gag-pol	0.0003
2237	Gag-Pol polyprotein	gag-pol	0.0003
2326	Gag-Pol polyprotein	gag-pol	0.0003
2451	Gag-Pol polyprotein	gag-pol	0.0003
2901	Gag-Pol polyprotein	gag-pol	0.0003
3165	Gag-Pol polyprotein	gag-pol	0.0003
3722	Gag-Pol polyprotein	gag-pol	0.0003
6306	Gag-Pol polyprotein	gag-pol	0.0003
6624	Gag-Pol polyprotein	gag-pol	0.0003
2427	Ferrichrome-iron receptor	fhuA	0.0003
6264	cAMP-dependent protein kinase inhibitor alpha	PKIA	0.0003
6263	cAMP-dependent protein kinase catalytic subunit alpha	PRKACA	0.0003

(*) Categorization taken from DrugBank: therapeutic category or general category of a drug (i.e. anti-convulsant, antibacterial, etc.)

DB01232 - Saquinavir

Targets

Enzymes

Transporters

Carriers

Predictions