Identification
Name Flurazepam
Accession Number DB00690 (APRD00983)
Type small molecule
Description A benzodiazepine derivative used mainly as a hypnotic. [PubChem]
Structure
Categories (*)
Molecular Weight 387.878
Groups illicit
Monoisotopic Weight 387.151368285
Pharmacology
Indication For short-term and intermittent use in patients with recurring insomnia and poor sleeping habits
Mechanism of action Flurazepam binds to an allosteric site on GABA-A receptors. Binding potentiates the action of GABA on GABA-A receptors by opening the chloride channel within the receptor, causing chloride influx and hyperpolarization.
Absorption Flurazepam hydrochloride is rapidly (30 minutes) absorbed from the gastrointestinal tract
Protein binding 83%
Biotransformation Flurazepam is rapidly metabolized and is excreted primarily in the urine. Both hydroxyethyl flurazepam (the major metabolite) and N-desalkyl flurazepam are active. The N-desalkyl metabolite is slowly excreted in the urine as the conjugated form
Route of elimination Flurazepam is rapidly metabolized and is excreted primarily in the urine. Less than 1% of the dose is excreted in the urine as N1-desalkyl-flurazepam.
Toxicity Coma, confusion, low blood pressure, sleepiness
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Amprenavir Amprenavir may increase the effect and toxicity of the benzodiazepine, flurazepam.
Cimetidine Cimetidine may increase the effect of the benzodiazepine, flurazepam.
Clozapine Increased risk of toxicity
Ethotoin Ethotoin may increase the metabolism of flurazepam via CYP3A4.
Fluconazole Fluconazole may increase the effect of the benzodiazepine, flurazepam.
Fosamprenavir Fosamprenavir may increase the effect and toxicity of the benzodiazepine, flurazepam.
Fosphenytoin Fosphenytoin may increase the metabolism of flurazepam via CYP3A4.
Indinavir The protease inhibitor, indinavir, may increase the effect of the benzodiazepine, flurazepam.
Itraconazole Itraconazole may increase the effect of the benzodiazepine, flurazepam.
Kava Kava may increase the effect of the benzodiazepine, flurazepam.
Ketoconazole Ketoconazole may increase the effect of the benzodiazepine, flurazepam.
Mephenytoin Mephenytoin may increase the metabolism of flurazepam via CYP3A4.
Nelfinavir The protease inhibitor, nelfinavir, may increase the effect of the benzodiazepine, flurazepam.
Omeprazole Omeprazole may increase the effect of the benzodiazepine, flurazepam.
Phenytoin Phenytoin may increase the metabolism of flurazepam via CYP3A4.
Ritonavir The protease inhibitor, ritonavir, may increase the effect of the benzodiazepine, flurazepam.
Saquinavir The protease inhibitor, saquinavir, may increase the effect of the benzodiazepine, flurazepam.
Telithromycin Telithromycin may reduce clearance of Flurazepam. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Flurazepam if Telithromycin is initiated, discontinued or dose changed.
Tipranavir Tipranavir may decrease the metabolism and clearance of Flurazepam. Consider alternate therapy or monitor for Flurazepam toxic effects if Tipranavir is initiated or dose increased.
Triprolidine The CNS depressants, Triprolidine and Flurazepam, may increase adverse/toxic effects due to additivity. Monitor for increased CNS depressant effects during concomitant therapy.
Voriconazole Voriconazole, a strong CYP3A4 inhibitor, may increase the serum concentration of flurazepam by decreasing its metabolism. Monitor for flurazepam toxicity if voriconazole is initiated or dose increased.
Food Interactions
  • Take without regard to meals.
  • Avoid alcohol.
Gamma-aminobutyric-acid receptor subunit alpha-1
Name Gamma-aminobutyric-acid receptor subunit alpha-1
Gene Name GABRA1
Pharmacological action yes
Actions potentiator
References
  • Mohler H, Fritschy JM, Rudolph U: A new benzodiazepine pharmacology. J Pharmacol Exp Ther. 2002 Jan;300(1):2-8. - Pubmed
  • Riss J, Cloyd J, Gates J, Collins S: Benzodiazepines in epilepsy: pharmacology and pharmacokinetics. Acta Neurol Scand. 2008 Aug;118(2):69-86. Epub 2008 Mar 31. - Pubmed
DTHybrid score 1.2485
Gamma-aminobutyric-acid receptor subunit alpha-2
Name Gamma-aminobutyric-acid receptor subunit alpha-2
Gene Name GABRA2
Pharmacological action yes
Actions potentiator
References
  • Mohler H, Fritschy JM, Rudolph U: A new benzodiazepine pharmacology. J Pharmacol Exp Ther. 2002 Jan;300(1):2-8. - Pubmed
  • Riss J, Cloyd J, Gates J, Collins S: Benzodiazepines in epilepsy: pharmacology and pharmacokinetics. Acta Neurol Scand. 2008 Aug;118(2):69-86. Epub 2008 Mar 31. - Pubmed
DTHybrid score 1.1828
Gamma-aminobutyric-acid receptor subunit alpha-3
Name Gamma-aminobutyric-acid receptor subunit alpha-3
Gene Name GABRA3
Pharmacological action yes
Actions potentiator
References
  • Mohler H, Fritschy JM, Rudolph U: A new benzodiazepine pharmacology. J Pharmacol Exp Ther. 2002 Jan;300(1):2-8. - Pubmed
  • Riss J, Cloyd J, Gates J, Collins S: Benzodiazepines in epilepsy: pharmacology and pharmacokinetics. Acta Neurol Scand. 2008 Aug;118(2):69-86. Epub 2008 Mar 31. - Pubmed
DTHybrid score 1.1798
Gamma-aminobutyric-acid receptor subunit alpha-4
Name Gamma-aminobutyric-acid receptor subunit alpha-4
Gene Name GABRA4
Pharmacological action yes
Actions potentiator
References
  • Mohler H, Fritschy JM, Rudolph U: A new benzodiazepine pharmacology. J Pharmacol Exp Ther. 2002 Jan;300(1):2-8. - Pubmed
  • Riss J, Cloyd J, Gates J, Collins S: Benzodiazepines in epilepsy: pharmacology and pharmacokinetics. Acta Neurol Scand. 2008 Aug;118(2):69-86. Epub 2008 Mar 31. - Pubmed
DTHybrid score 0.848
Gamma-aminobutyric-acid receptor subunit alpha-5
Name Gamma-aminobutyric-acid receptor subunit alpha-5
Gene Name GABRA5
Pharmacological action yes
Actions potentiator
References
  • Mohler H, Fritschy JM, Rudolph U: A new benzodiazepine pharmacology. J Pharmacol Exp Ther. 2002 Jan;300(1):2-8. - Pubmed
  • Riss J, Cloyd J, Gates J, Collins S: Benzodiazepines in epilepsy: pharmacology and pharmacokinetics. Acta Neurol Scand. 2008 Aug;118(2):69-86. Epub 2008 Mar 31. - Pubmed
DTHybrid score 1.2058
Gamma-aminobutyric-acid receptor subunit alpha-6
Name Gamma-aminobutyric-acid receptor subunit alpha-6
Gene Name GABRA6
Pharmacological action yes
Actions potentiator
References
  • Mohler H, Fritschy JM, Rudolph U: A new benzodiazepine pharmacology. J Pharmacol Exp Ther. 2002 Jan;300(1):2-8. - Pubmed
  • Riss J, Cloyd J, Gates J, Collins S: Benzodiazepines in epilepsy: pharmacology and pharmacokinetics. Acta Neurol Scand. 2008 Aug;118(2):69-86. Epub 2008 Mar 31. - Pubmed
DTHybrid score 0.8167
Gamma-aminobutyric-acid receptor subunit beta-1
Name Gamma-aminobutyric-acid receptor subunit beta-1
Gene Name GABRB1
Pharmacological action yes
Actions potentiator
References
  • Mohler H, Fritschy JM, Rudolph U: A new benzodiazepine pharmacology. J Pharmacol Exp Ther. 2002 Jan;300(1):2-8. - Pubmed
  • Riss J, Cloyd J, Gates J, Collins S: Benzodiazepines in epilepsy: pharmacology and pharmacokinetics. Acta Neurol Scand. 2008 Aug;118(2):69-86. Epub 2008 Mar 31. - Pubmed
DTHybrid score 1.0583
Gamma-aminobutyric-acid receptor subunit beta-2
Name Gamma-aminobutyric-acid receptor subunit beta-2
Gene Name GABRB2
Pharmacological action yes
Actions potentiator
References
  • Mohler H, Fritschy JM, Rudolph U: A new benzodiazepine pharmacology. J Pharmacol Exp Ther. 2002 Jan;300(1):2-8. - Pubmed
  • Riss J, Cloyd J, Gates J, Collins S: Benzodiazepines in epilepsy: pharmacology and pharmacokinetics. Acta Neurol Scand. 2008 Aug;118(2):69-86. Epub 2008 Mar 31. - Pubmed
DTHybrid score 1.0472
Gamma-aminobutyric-acid receptor subunit beta-3
Name Gamma-aminobutyric-acid receptor subunit beta-3
Gene Name GABRB3
Pharmacological action yes
Actions potentiator
References
  • Mohler H, Fritschy JM, Rudolph U: A new benzodiazepine pharmacology. J Pharmacol Exp Ther. 2002 Jan;300(1):2-8. - Pubmed
  • Riss J, Cloyd J, Gates J, Collins S: Benzodiazepines in epilepsy: pharmacology and pharmacokinetics. Acta Neurol Scand. 2008 Aug;118(2):69-86. Epub 2008 Mar 31. - Pubmed
DTHybrid score 1.0634
Gamma-aminobutyric acid receptor subunit gamma-1
Name Gamma-aminobutyric acid receptor subunit gamma-1
Gene Name GABRG1
Pharmacological action yes
Actions potentiator
References
  • Mohler H, Fritschy JM, Rudolph U: A new benzodiazepine pharmacology. J Pharmacol Exp Ther. 2002 Jan;300(1):2-8. - Pubmed
  • Riss J, Cloyd J, Gates J, Collins S: Benzodiazepines in epilepsy: pharmacology and pharmacokinetics. Acta Neurol Scand. 2008 Aug;118(2):69-86. Epub 2008 Mar 31. - Pubmed
DTHybrid score 1.046
Gamma-aminobutyric acid receptor subunit gamma-2
Name Gamma-aminobutyric acid receptor subunit gamma-2
Gene Name GABRG2
Pharmacological action yes
Actions potentiator
References
  • Mohler H, Fritschy JM, Rudolph U: A new benzodiazepine pharmacology. J Pharmacol Exp Ther. 2002 Jan;300(1):2-8. - Pubmed
  • Riss J, Cloyd J, Gates J, Collins S: Benzodiazepines in epilepsy: pharmacology and pharmacokinetics. Acta Neurol Scand. 2008 Aug;118(2):69-86. Epub 2008 Mar 31. - Pubmed
DTHybrid score 1.0783
Gamma-aminobutyric acid receptor subunit gamma-3
Name Gamma-aminobutyric acid receptor subunit gamma-3
Gene Name GABRG3
Pharmacological action yes
Actions potentiator
References
  • Mohler H, Fritschy JM, Rudolph U: A new benzodiazepine pharmacology. J Pharmacol Exp Ther. 2002 Jan;300(1):2-8. - Pubmed
  • Riss J, Cloyd J, Gates J, Collins S: Benzodiazepines in epilepsy: pharmacology and pharmacokinetics. Acta Neurol Scand. 2008 Aug;118(2):69-86. Epub 2008 Mar 31. - Pubmed
DTHybrid score 1.0276
Gamma-aminobutyric acid receptor subunit delta
Name Gamma-aminobutyric acid receptor subunit delta
Gene Name GABRD
Pharmacological action yes
Actions potentiator
References
  • Mohler H, Fritschy JM, Rudolph U: A new benzodiazepine pharmacology. J Pharmacol Exp Ther. 2002 Jan;300(1):2-8. - Pubmed
  • Riss J, Cloyd J, Gates J, Collins S: Benzodiazepines in epilepsy: pharmacology and pharmacokinetics. Acta Neurol Scand. 2008 Aug;118(2):69-86. Epub 2008 Mar 31. - Pubmed
DTHybrid score 1.0346
Gamma-aminobutyric acid receptor subunit epsilon
Name Gamma-aminobutyric acid receptor subunit epsilon
Gene Name GABRE
Pharmacological action yes
Actions potentiator
References
  • Mohler H, Fritschy JM, Rudolph U: A new benzodiazepine pharmacology. J Pharmacol Exp Ther. 2002 Jan;300(1):2-8. - Pubmed
  • Riss J, Cloyd J, Gates J, Collins S: Benzodiazepines in epilepsy: pharmacology and pharmacokinetics. Acta Neurol Scand. 2008 Aug;118(2):69-86. Epub 2008 Mar 31. - Pubmed
DTHybrid score 1.0328
Gamma-aminobutyric acid receptor subunit pi
Name Gamma-aminobutyric acid receptor subunit pi
Gene Name GABRP
Pharmacological action yes
Actions potentiator
References
  • Mohler H, Fritschy JM, Rudolph U: A new benzodiazepine pharmacology. J Pharmacol Exp Ther. 2002 Jan;300(1):2-8. - Pubmed
  • Riss J, Cloyd J, Gates J, Collins S: Benzodiazepines in epilepsy: pharmacology and pharmacokinetics. Acta Neurol Scand. 2008 Aug;118(2):69-86. Epub 2008 Mar 31. - Pubmed
DTHybrid score 1.0183
Gamma-aminobutyric-acid receptor subunit rho-1
Name Gamma-aminobutyric-acid receptor subunit rho-1
Gene Name GABRR1
Pharmacological action yes
Actions potentiator
References
  • Mohler H, Fritschy JM, Rudolph U: A new benzodiazepine pharmacology. J Pharmacol Exp Ther. 2002 Jan;300(1):2-8. - Pubmed
  • Riss J, Cloyd J, Gates J, Collins S: Benzodiazepines in epilepsy: pharmacology and pharmacokinetics. Acta Neurol Scand. 2008 Aug;118(2):69-86. Epub 2008 Mar 31. - Pubmed
DTHybrid score 1.0238
Gamma-aminobutyric acid receptor subunit rho-2
Name Gamma-aminobutyric acid receptor subunit rho-2
Gene Name GABRR2
Pharmacological action yes
Actions potentiator
References
  • Mohler H, Fritschy JM, Rudolph U: A new benzodiazepine pharmacology. J Pharmacol Exp Ther. 2002 Jan;300(1):2-8. - Pubmed
  • Riss J, Cloyd J, Gates J, Collins S: Benzodiazepines in epilepsy: pharmacology and pharmacokinetics. Acta Neurol Scand. 2008 Aug;118(2):69-86. Epub 2008 Mar 31. - Pubmed
DTHybrid score 1.0292
Gamma-aminobutyric acid receptor subunit rho-3
Name Gamma-aminobutyric acid receptor subunit rho-3
Gene Name GABRR3
Pharmacological action yes
Actions potentiator
References
  • Mohler H, Fritschy JM, Rudolph U: A new benzodiazepine pharmacology. J Pharmacol Exp Ther. 2002 Jan;300(1):2-8. - Pubmed
  • Riss J, Cloyd J, Gates J, Collins S: Benzodiazepines in epilepsy: pharmacology and pharmacokinetics. Acta Neurol Scand. 2008 Aug;118(2):69-86. Epub 2008 Mar 31. - Pubmed
DTHybrid score 1.0262
Gamma-aminobutyric acid receptor subunit theta
Name Gamma-aminobutyric acid receptor subunit theta
Gene Name GABRQ
Pharmacological action yes
Actions potentiator
References
  • Mohler H, Fritschy JM, Rudolph U: A new benzodiazepine pharmacology. J Pharmacol Exp Ther. 2002 Jan;300(1):2-8. - Pubmed
  • Riss J, Cloyd J, Gates J, Collins S: Benzodiazepines in epilepsy: pharmacology and pharmacokinetics. Acta Neurol Scand. 2008 Aug;118(2):69-86. Epub 2008 Mar 31. - Pubmed
DTHybrid score 0.6769
Cytochrome P450 2E1
Name Cytochrome P450 2E1
Gene Name CYP2E1
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.441
Cytochrome P450 2A6
Name Cytochrome P450 2A6
Gene Name CYP2A6
Actions substrate
References
  • -
  • Capello S, Henderson L, DeGrazia F, Liberato D, Garland W, Town C: The effect of the cytochrome P-450 suicide inactivator, 1-aminobenzotriazole, on the in vivo metabolism and pharmacologic activity of flurazepam. Drug Metab Dispos. 1990 Mar-Apr;18(2):190-6. - Pubmed
  • Linder CD, Renaud NA, Hutzler JM: Is 1-aminobenzotriazole an appropriate in vitro tool as a nonspecific cytochrome P450 inactivator? Drug Metab Dispos. 2009 Jan;37(1):10-3. Epub 2008 Oct 20. - Pubmed
DTHybrid score 0.3335
Cytochrome P450 3A4
Name Cytochrome P450 3A4
Gene Name CYP3A4
Actions substrate
References
  • -
  • Capello S, Henderson L, DeGrazia F, Liberato D, Garland W, Town C: The effect of the cytochrome P-450 suicide inactivator, 1-aminobenzotriazole, on the in vivo metabolism and pharmacologic activity of flurazepam. Drug Metab Dispos. 1990 Mar-Apr;18(2):190-6. - Pubmed
  • Linder CD, Renaud NA, Hutzler JM: Is 1-aminobenzotriazole an appropriate in vitro tool as a nonspecific cytochrome P450 inactivator? Drug Metab Dispos. 2009 Jan;37(1):10-3. Epub 2008 Oct 20. - Pubmed
DTHybrid score 0.8453
Multidrug resistance protein 1
Name Multidrug resistance protein 1
Gene Name ABCB1
Actions inhibitor
References
  • Mahar Doan KM, Humphreys JE, Webster LO, Wring SA, Shampine LJ, Serabjit-Singh CJ, Adkison KK, Polli JW: Passive permeability and P-glycoprotein-mediated efflux differentiate central nervous system (CNS) and non-CNS marketed drugs. J Pharmacol Exp Ther. 2002 Dec;303(3):1029-37. - Pubmed
DTHybrid score 0.4401
Solute carrier family 22 member 2
Name Solute carrier family 22 member 2
Gene Name SLC22A2
Actions inhibitor
References
  • Zolk O, Solbach TF, Konig J, Fromm MF: Functional characterization of the human organic cation transporter 2 variant p.270Ala>Ser. Drug Metab Dispos. 2009 Jun;37(6):1312-8. doi: 10.1124/dmd.108.023762. Epub 2009 Feb 27. - Pubmed
DTHybrid score 0.1891
Id Partner name Gene Name Score
811 Translocator protein TSPO 0.3938
6016 Cytochrome P450 2C19 CYP2C19 0.3771
4757 Cytochrome P450 2C9 CYP2C9 0.3319
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.294
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.2938
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.285
6030 Cytochrome P450 2B6 CYP2B6 0.2605
921 Glutamate receptor 2 GRIA2 0.2517
4119 Cytochrome P450 2D6 CYP2D6 0.2464
4200 Cytochrome P450 1A2 CYP1A2 0.2438
4118 Cytochrome P450 3A5 CYP3A5 0.2424
4924 Cytochrome P450 2C8 CYP2C8 0.2213
6107 Cytochrome P450 3A7 CYP3A7 0.2114
6106 Cytochrome P450 2C18 CYP2C18 0.1316
587 Serum albumin ALB 0.1299
6145 Solute carrier family 22 member 1 SLC22A1 0.1151
6024 Cytochrome P450 1A1 CYP1A1 0.1068
20 Prostaglandin G/H synthase 1 PTGS1 0.0869
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0678
6102 Arylamine N-acetyltransferase 2 NAT2 0.0596
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0577
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0568
482 Glycine receptor subunit alpha-1 GLRA1 0.0543
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0535
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0528
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0522
6031 Cytochrome P450 3A43 CYP3A43 0.0522
862 Multidrug resistance-associated protein 1 ABCC1 0.0493
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0476
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0475
6147 Solute carrier family 22 member 3 SLC22A3 0.0463
3811 Cytochrome P450 19A1 CYP19A1 0.0447
118 Organic cation/carnitine transporter 2 SLC22A5 0.0444
492 Histamine H1 receptor HRH1 0.039
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0384
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0384
556 Alpha-1A adrenergic receptor ADRA1A 0.0378
1898 Cytochrome P450 1B1 CYP1B1 0.0377
776 Bile salt export pump ABCB11 0.0375
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0372
1729 Solute carrier family 22 member 6 SLC22A6 0.0367
461 Glycine receptor subunit alpha-3 GLRA3 0.0364
766 Beta-2 adrenergic receptor ADRB2 0.0357
6027 Alkaline phosphatase, tissue-nonspecific isozyme ALPL 0.035
824 Sodium-dependent serotonin transporter SLC6A4 0.034
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0305
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0302
871 Glucocorticoid receptor NR3C1 0.03
820 Glycine receptor subunit alpha-2 GLRA2 0.0298
833 Organic cation/carnitine transporter 1 SLC22A4 0.0298
6142 Solute carrier family 22 member 8 SLC22A8 0.0296
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0291
831 D(2) dopamine receptor DRD2 0.0289
193 Beta-1 adrenergic receptor ADRB1 0.028
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0278
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0274
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0274
502 5-hydroxytryptamine 2A receptor HTR2A 0.0274
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0269
3937 Fatty-acid amide hydrolase FAAH 0.0268
468 Cytochrome P450 4A11 CYP4A11 0.0265
136 Estrogen receptor ESR1 0.0265
318 Alpha-2A adrenergic receptor ADRA2A 0.0263
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0259
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0255
537 ATP synthase delta chain, mitochondrial ATP5D 0.0246
705 Glutamate receptor 1 GRIA1 0.0245
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0233
260 Cytochrome P450 51 ERG11 0.0232
761 Cytochrome P450 51 ERG11 0.0232
3163 Cytochrome P450 51 cyp51 0.0232
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0231
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0227
3923 Cholinesterase BCHE 0.0224
23 D(1A) dopamine receptor DRD1 0.0224
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0219
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0219
341 5-hydroxytryptamine 3 receptor HTR3A 0.0216
6143 Solute carrier family 22 member 7 SLC22A7 0.0214
320 5-hydroxytryptamine 1A receptor HTR1A 0.0202
290 Prostaglandin G/H synthase 2 PTGS2 0.0198
2981 Phospholipase A2, membrane associated PLA2G2A 0.0195
632 Alpha-1B adrenergic receptor ADRA1B 0.0191
3426 Glutamine synthetase glnA 0.0188
3987 Glutamine synthetase GLUL 0.0188
465 Calmodulin CALM1 0.0186
817 DNA topoisomerase 2-alpha TOP2A 0.0184
629 Alpha-2B adrenergic receptor ADRA2B 0.0183
789 Alpha-1D adrenergic receptor ADRA1D 0.0177
590 5-hydroxytryptamine 2C receptor HTR2C 0.0176
713 Sodium-dependent dopamine transporter SLC6A3 0.0174
2164 Multidrug resistance-associated protein 4 ABCC4 0.0174
172 Potassium channel subfamily K member 1 KCNK1 0.0173
3939 Amine oxidase [flavin-containing] B MAOB 0.0169
6014 Cytochrome P450 2A13 CYP2A13 0.0167
124 Histamine H2 receptor HRH2 0.0167
738 Monocarboxylate transporter 1 SLC16A1 0.0165
3941 Amine oxidase [flavin-containing] A MAOA 0.0161
1024 Solute carrier family 22 member 11 SLC22A11 0.0161
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.016
378 Alpha-2C adrenergic receptor ADRA2C 0.016
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0157
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0157
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0154
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0153
885 5-hydroxytryptamine 1B receptor HTR1B 0.0153
847 Mu-type opioid receptor OPRM1 0.0152
240 Gamma-aminobutyric acid type B receptor, subunit 1 GABBR1 0.0151
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.015
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0147
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0146
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0146
731 HIV-1 protease HIV-1 protease 0.0145
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0144
7 Nitric oxide synthase, inducible NOS2 0.0144
489 Monocarboxylate transporter 2 SLC16A7 0.014
6148 Multidrug resistance-associated protein 7 ABCC10 0.0135
62 Glycine receptor subunit beta GLRB 0.0132
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0132
6137 Multidrug resistance-associated protein 6 ABCC6 0.0131
6136 Multidrug resistance-associated protein 5 ABCC5 0.0131
477 DNA topoisomerase 4 subunit A parC 0.013
886 DNA topoisomerase 4 subunit A parC 0.013
6226 DNA topoisomerase 4 subunit A parC 0.013
638 D(3) dopamine receptor DRD3 0.0128
467 Delta-type opioid receptor OPRD1 0.0128
404 DNA gyrase subunit A gyrA 0.0128
6224 DNA gyrase subunit A gyrA 0.0128
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0127
725 5-hydroxytryptamine 1D receptor HTR1D 0.0126
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0123
232 Corticosteroid-binding globulin SERPINA6 0.0123
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0123
614 Progesterone receptor PGR 0.0122
474 Acetylcholinesterase ACHE 0.0122
442 Envelope glycoprotein gp41 0.012
4859 Envelope glycoprotein env 0.012
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0118
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0118
500 Monocarboxylate transporter 4 SLC16A3 0.0118
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0117
4237 50S ribosomal protein L22 rplV 0.0117
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0116
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0115
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0112
4604 Liver carboxylesterase 1 CES1 0.0112
436 5-hydroxytryptamine 2B receptor HTR2B 0.011
696 Kappa-type opioid receptor OPRK1 0.0109
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0109
869 Estrogen receptor beta ESR2 0.0109
2230 Catalase CAT 0.0109
3249 Catalase katA 0.0109
3625 Catalase katA 0.0109
4539 Catalase katA 0.0109
4941 Catalase katB 0.0109
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0108
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0108
251 Alcohol dehydrogenase 1A ADH1A 0.0108
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0108
161 Tubulin beta chain TUBB 0.0108
312 Tubulin beta chain TUB2 0.0108
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0108
4238 50S ribosomal protein L4 rplD 0.0106
5578 50S ribosomal protein L4 rplD 0.0106
6173 50S ribosomal protein L4 rplD 0.0106
6219 50S ribosomal protein L4 rplD 0.0106
444 Alcohol dehydrogenase 1B ADH1B 0.0106
3947 Xanthine dehydrogenase/oxidase XDH 0.0106
1192 Sulfotransferase 1A1 SULT1A1 0.0103
6141 Sodium/bile acid cotransporter SLC10A1 0.0103
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0102
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0102
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0098
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0097
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0094
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0093
723 Cytosolic phospholipase A2 PLA2G4A 0.0092
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0091
432 D(4) dopamine receptor DRD4 0.0091
777 Tumor necrosis factor TNF 0.0091
6020 Aldehyde oxidase AOX1 0.009
4773 Deoxycytidine kinase DCK 0.0089
844 Epidermal growth factor receptor EGFR 0.0089
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0089
6182 Cytochrome P450 2J2 CYP2J2 0.0088
16 Adenosine A1 receptor ADORA1 0.0087
122 P2Y purinoceptor 12 P2RY12 0.0087
6010 Thiamine transporter 1 SLC19A2 0.0086
131 Synaptic vesicular amine transporter SLC18A2 0.0086
517 Alcohol dehydrogenase 1C ADH1C 0.0085
818 50S ribosomal protein L10 rplJ 0.0085
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0083
716 5-hydroxytryptamine 7 receptor HTR7 0.0083
4148 Serine/threonine-protein kinase mTOR MTOR 0.0083
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0083
380 Cytochrome P450 17A1 CYP17A1 0.0083
4203 Histamine N-methyltransferase HNMT 0.0082
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.0082
592 Carbonic anhydrase 4 CA4 0.0082
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0082
80 Peroxisome proliferator-activated receptor alpha PPARA 0.008
29 Tubulin beta-1 chain TUBB1 0.008
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0079
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0079
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0079
1770 Phospholipase C PLCL1 0.0079
2841 Phospholipase C plc 0.0079
2449 Tubulin alpha-3 chain TUBA1A 0.0078
4120 NADPH--cytochrome P450 reductase POR 0.0077
952 Dipeptidyl peptidase 4 DPP4 0.0077
891 Dihydropteroate synthase folP 0.0077
5359 Dihydropteroate synthase folP 0.0077
7175 Dihydropteroate synthase sulI 0.0077
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0077
175 Thiamin pyrophosphokinase 1 TPK1 0.0077
3932 Glutathione S-transferase A2 GSTA2 0.0076
1010 Cytochrome P450 51A1 CYP51A1 0.0076
68 Cannabinoid receptor 1 CNR1 0.0075
281 5'-AMP-activated protein kinase subunit beta-1 PRKAB1 0.0074
1178 Adenosine A2a receptor ADORA2A 0.0074
613 Atrial natriuretic peptide receptor A NPR1 0.0074
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0073
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0073
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.0073
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0073
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0073
737 Mineralocorticoid receptor NR3C2 0.0072
504 Mast/stem cell growth factor receptor KIT 0.0071
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.007
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.007
3810 Catechol O-methyltransferase COMT 0.007
904 Glutathione S-transferase P GSTP1 0.0069
373 Transthyretin TTR 0.0069
244 Angiotensin-converting enzyme ACE 0.0068
756 Sex hormone-binding globulin SHBG 0.0068
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0066
6432 Transporter snf 0.0064
3432 Multidrug-efflux transporter 1 regulator bmrR 0.0063
4476 Mannitol dehydrogenase mtlD 0.0063
1353 DNA topoisomerase 1 TOP1 0.0063
3552 DNA topoisomerase 1 topA 0.0063
163 D(1B) dopamine receptor DRD5 0.0062
6138 Multidrug resistance protein 3 ABCB4 0.0062
1517 Beta-3 adrenergic receptor ADRB3 0.0061
1757 Myeloperoxidase MPO 0.0061
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0061
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0061
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0061
357 Carbonic anhydrase 2 CA2 0.006
185 Vasopressin V1a receptor AVPR1A 0.006
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.006
694 Matrix protein 2 M 0.0059
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0058
2298 Cytochrome P450-cam camC 0.0058
322 Vasopressin V2 receptor AVPR2 0.0058
94 5-hydroxytryptamine 4 receptor HTR4 0.0058
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0058
295 Carbonic anhydrase 1 CA1 0.0058
518 Peroxidase/catalase T katG 0.0058
908 Glutathione S-transferase theta-1 GSTT1 0.0058
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0057
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0057
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0057
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0056
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0056
146 Androgen receptor AR 0.0056
228 Beta platelet-derived growth factor receptor PDGFRB 0.0056
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.0056
153 Dopamine beta-hydroxylase DBH 0.0054
563 Thyroid peroxidase TPO 0.0054
4217 Telomerase reverse transcriptase TERT 0.0054
164 Histamine H4 receptor HRH4 0.0053
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0053
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0053
1629 Transcription factor AP-1 JUN 0.0053
528 5-hydroxytryptamine 1E receptor HTR1E 0.0052
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0052
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0052
407 Vascular endothelial growth factor receptor 2 KDR 0.0051
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0051
814 Ryanodine receptor 1 RYR1 0.0051
3823 Cytokine receptor common gamma chain IL2RG 0.0051
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0051
70 Type-1 angiotensin II receptor AGTR1 0.0051
6220 Aryl hydrocarbon receptor AHR 0.0051
4122 Histone deacetylase 2 HDAC2 0.0051
2499 Tubulin beta-2C chain TUBB2C 0.0051
3611 Cytidine deaminase cdd 0.005
3707 Cytidine deaminase cdd 0.005
4211 Cytidine deaminase CDA 0.005
275 Arachidonate 5-lipoxygenase ALOX5 0.005
1680 Solute carrier family 2, facilitated glucose transporter member 1 SLC2A1 0.0049
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0049
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0049
284 DNA-directed RNA polymerase beta chain rpoB 0.0049
5773 DNA-directed RNA polymerase beta chain rpoB 0.0049
1830 5'-nucleotidase NT5E 0.0049
976 Platelet glycoprotein IX GP9 0.0049
6146 High affinity copper uptake protein 1 SLC31A1 0.0048
6070 Nischarin NISCH 0.0048
106 Cannabinoid receptor 2 CNR2 0.0048
6766 O-GlcNAcase BT_4395 BT_4395 0.0048
26 Vascular endothelial growth factor receptor 3 FLT4 0.0047
3809 Estrogen-related receptor gamma ESRRG 0.0047
982 Cocaine- and amphetamine-regulated transcript protein CARTPT 0.0047
6174 50S ribosomal protein L32 rpmF 0.0047
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0047
2616 Ganglioside GM2 activator GM2A 0.0047
6163 Copper-transporting ATPase 2 ATP7B 0.0047
6165 Copper-transporting ATPase 1 ATP7A 0.0047
125 DNA polymerase beta POLB 0.0047
683 Potassium transporter GK0582 0.0047
3917 Methylenetetrahydrofolate reductase MTHFR 0.0046
32 Vascular endothelial growth factor receptor 1 FLT1 0.0045
239 Coagulation factor X F10 0.0045
790 DNA polymerase subunit alpha B POLA2 0.0045
896 Glutathione S-transferase Mu 1 GSTM1 0.0045
724 Interleukin-2 receptor alpha chain IL2RA 0.0045
717 Interleukin-2 receptor subunit beta IL2RB 0.0045
2178 Metabotropic glutamate receptor 5 GRM5 0.0045
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0044
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0044
6211 Tubulin epsilon chain TUBE1 0.0044
6212 Tubulin gamma-1 chain TUBG1 0.0044
6210 Tubulin delta chain TUBD1 0.0044
1050 Bile salt sulfotransferase SULT2A1 0.0044
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0044
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0044
4116 Dihydropteroate synthetase Not Available 0.0044
2472 Voltage-gated potassium channel kcsA 0.0043
6366 Voltage-gated potassium channel kcsA 0.0043
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0043
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0043
4192 DNA topoisomerase 2-beta TOP2B 0.0043
1256 5-hydroxytryptamine 6 receptor HTR6 0.0043
84 Nuclear receptor 0B1 NR0B1 0.0043
1360 Sphingomyelin phosphodiesterase SMPD1 0.0042
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0042
319 Opioid receptor, sigma 1 OPRS1 0.0042
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0042
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0042
768 FK506-binding protein 1A FKBP1A 0.0042
1852 Microtubule-associated protein 2 MAP2 0.0042
2320 Thymidine kinase, cytosolic TK1 0.0041
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0041
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0041
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0041
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0041
1268 Neuropeptide S receptor NPSR1 0.0041
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0041
1656 CYP2B protein CYP2B 0.0041
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0041
3997 Cytochrome P450 24A1, mitochondrial CYP24A1 0.0041
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.004
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.004
828 Phenylalanine-4-hydroxylase PAH 0.004
3109 Phenylalanine-4-hydroxylase phhA 0.004
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.004
365 Dihydrofolate reductase DHFR 0.0039
2381 Dihydrofolate reductase DFR1 0.0039
2833 Dihydrofolate reductase Not Available 0.0039
2931 Dihydrofolate reductase folA 0.0039
3544 Dihydrofolate reductase folA 0.0039
3682 Dihydrofolate reductase folA 0.0039
6642 Dihydrofolate reductase folA 0.0039
6756 Dihydrofolate reductase dfrA 0.0039
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0039
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0039
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0039
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0039
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0039
1129 C-C chemokine receptor type 5 CCR5 0.0039
24 Thymidylate synthase TMP1 0.0039
359 Thymidylate synthase TYMS 0.0039
2626 Thymidylate synthase thyA 0.0039
2729 Thymidylate synthase thyA 0.0039
5352 Thymidylate synthase THYA 0.0039
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0038
4164 Potassium voltage-gated channel subfamily KQT member 5 KCNQ5 0.0038
4163 Potassium voltage-gated channel subfamily KQT member 4 KCNQ4 0.0038
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0038
1618 High affinity nerve growth factor receptor NTRK1 0.0038
511 5-hydroxytryptamine 1F receptor HTR1F 0.0038
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0038
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0038
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0038
1341 Histamine H3 receptor HRH3 0.0038
1483 Membrane copper amine oxidase AOC3 0.0038
2539 Tubulin alpha-1 chain TUBA4A 0.0037
6073 Potassium channel subfamily K member 9 KCNK9 0.0037
6072 Potassium channel subfamily K member 3 KCNK3 0.0037
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0037
1064 DNA (cytosine-5)-methyltransferase 1 DNMT1 0.0037
390 Adenosine A3 receptor ADORA3 0.0037
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0036
6126 Carbonic anhydrase 7 CA7 0.0036
527 Prostacyclin receptor PTGIR 0.0036
749 Amiloride-sensitive cation channel 1, neuronal ACCN1 0.0036
1636 Trace amine-associated receptor 1 TAAR1 0.0036
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0036
3404 Exotoxin A eta 0.0036
469 Annexin A1 ANXA1 0.0035
856 Vitamin D3 receptor VDR 0.0035
702 UMP-CMP kinase CMPK1 0.0035
672 Prostaglandin F2-alpha receptor PTGFR 0.0035
5126 Arginase rocF 0.0035
6085 Fatty acid-binding protein, intestinal FABP2 0.0035
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0035
939 50S ribosomal protein L3 rplC 0.0035
596 3-oxo-5-alpha-steroid 4-dehydrogenase 1 SRD5A1 0.0033
6043 Putative G-protein coupled receptor 44 GPR44 0.0033
400 Coagulation factor IX F9 0.0033
5461 Coagulation factor IX F9 0.0033
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0033
780 Retinoic acid receptor RXR-gamma RXRG 0.0032
2207 Rhodopsin RHO 0.0032
6167 Organic solute transporter subunit beta OSTB 0.0032
6166 Organic solute transporter subunit alpha OSTA 0.0032
6149 Solute carrier family 22 member 10 SLC22A10 0.0032
387 Amiloride-sensitive amine oxidase [copper-containing] ABP1 0.0032
7187 Amiloride-sensitive amine oxidase [copper-containing] ABP1 0.0032
54 Prothrombin F2 0.0032
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0032
2107 Microtubule-associated protein 1A MAP1A 0.0032
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0032
550 Amiloride-sensitive sodium channel subunit delta SCNN1D 0.0031
213 Amiloride-sensitive sodium channel subunit alpha SCNN1A 0.0031
3090 Chitosanase csn 0.0031
751 Potassium channel subfamily K member 6 KCNK6 0.0031
4149 Nuclear factor NF-kappa-B p100 subunit NFKB2 0.0031
140 30S ribosomal protein S9 rpsI 0.0031
6719 30S ribosomal protein S9 rpsI 0.0031
6725 30S ribosomal protein S9 rpsI 0.0031
27 Amiloride-sensitive sodium channel subunit beta SCNN1B 0.0031
552 Amiloride-sensitive sodium channel subunit gamma SCNN1G 0.0031
6111 DNA polymerase epsilon subunit 4 POLE4 0.0031
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0031
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.0031
6112 DNA polymerase epsilon subunit 3 POLE3 0.0031
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0031
6108 Ribonucleoside-diphosphate reductase subunit M2 B RRM2B 0.0031
6110 DNA polymerase epsilon subunit 2 POLE2 0.0031
6109 DNA polymerase epsilon catalytic subunit A POLE 0.0031
827 Sodium/hydrogen exchanger 1 SLC9A1 0.0031
65 Matrix metalloproteinase-9 Not Available 0.0031
473 L-lactate dehydrogenase A chain LDHA 0.0031
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0031
1275 Estrogen sulfotransferase SULT1E1 0.0031
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0031
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0031
2578 Tubulin beta-3 chain TUBB3 0.003
2300 Lysozyme E 0.003
3633 Lysozyme R 0.003
5597 Lysozyme 17 0.003
2285 Streptogramin A acetyltransferase vatD 0.003
4081 Vitamin K epoxide reductase complex subunit 1-like protein 1 VKORC1L1 0.003
604 Vitamin K-dependent protein Z PROZ 0.003
342 P protein [Includes: DNA-directed DNA polymerase P 0.003
612 P protein [Includes: DNA-directed DNA polymerase P 0.003
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.003
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.003
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.003
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.003
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.003
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.003
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.003
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.003
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.003
823 Fibroblast growth factor receptor 2 FGFR2 0.003
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.003
6171 Solute carrier family 28 member 3 SLC28A3 0.003
88 Retinoic acid receptor RXR-beta RXRB 0.003
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0029
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0029
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0029
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0029
2290 ADP-ribosyl cyclase 2 BST1 0.0028
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0028
1435 Synaptic vesicle glycoprotein 2A SV2A 0.0028
1253 Interferon gamma IFNG 0.0028
330 Spermidine synthase SRM 0.0028
3038 Spermidine synthase speE 0.0028
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0028
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0028
422 Vitamin K-dependent protein C PROC 0.0028
1245 Vitamin K-dependent protein S PROS1 0.0028
4103 Proteasome subunit beta type 2 PSMB2 0.0027
4102 Proteasome subunit beta type 5 PSMB5 0.0027
4101 Proteasome subunit beta type 1 PSMB1 0.0027
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0027
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0027
6232 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short GNAS 0.0027
6233 Adenylate cyclase type 2 ADCY2 0.0027
6234 Adenylate cyclase type 5 ADCY5 0.0027
624 Guanidinoacetate N-methyltransferase GAMT 0.0027
4173 Tyrosine-protein kinase JAK2 JAK2 0.0027
4218 Ribonucleoside-diphosphate reductase M2 subunit RRM2 0.0027
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0027
6824 Tyrosine-protein kinase Lyn LYN 0.0026
6599 HTH-type transcriptional regulator ttgR ttgR 0.0026
5626 Nucleoside diphosphate kinase B NME2 0.0026
5300 Antigen peptide transporter 1 TAP1 0.0026
1864 RET proto-oncogene RET 0.0026
5997 Tumor necrosis factor ligand superfamily member 11 TNFSF11 0.0026
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0026
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0026
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0026
49 Endothelin B receptor EDNRB 0.0026
427 Substance-P receptor TACR1 0.0026
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0025
1385 Angiotensin-converting enzyme 2 ACE2 0.0025
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0025
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0025
448 Vitamin K-dependent gamma-carboxylase GGCX 0.0024
605 Fumarate reductase flavoprotein subunit frdA 0.0024
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0024
3673 Fumarate reductase flavoprotein subunit fccA 0.0024
4912 Fumarate reductase flavoprotein subunit ifcA 0.0024
6549 Fumarate reductase flavoprotein subunit frdA 0.0024
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0024
578 Endothelin-1 receptor EDNRA 0.0024
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0024
334 S-adenosylmethionine synthetase isoform type-2 MAT2A 0.0024
544 Potassium voltage-gated channel subfamily E member 1 KCNE1 0.0024
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0024
6039 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A PDE11A 0.0024
233 Potassium channel subfamily K member 2 KCNK2 0.0024
183 Vascular endothelial growth factor A VEGFA 0.0024
5852 Type-2 angiotensin II receptor AGTR2 0.0024
165 FL cytokine receptor FLT3 0.0024
603 DNA polymerase alpha catalytic subunit POLA1 0.0024
642 3-oxo-5-alpha-steroid 4-dehydrogenase 2 SRD5A2 0.0023
4221 Vascular endothelial growth factor VEGF 0.0023
1374 Natriuretic peptides B NPPB 0.0023
6218 Pannexin-1 PANX1 0.0023
1827 Gap junction alpha-1 protein GJA1 0.0023
5816 Cadherin-5 CDH5 0.0023
1908 Vascular cell adhesion protein 1 VCAM1 0.0023
358 Cystathionine beta-synthase CBS 0.0023
453 S-adenosylmethionine synthetase isoform type-1 MAT1A 0.0023
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0023
2599 Tyrosine-protein kinase HCK HCK 0.0022
798 Osteocalcin BGLAP 0.0022
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0022
113 S-adenosylmethionine decarboxylase proenzyme AMD1 0.0022
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0022
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0022
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0022
686 Aldo-keto reductase family 1 member C2 AKR1C2 0.0022
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.0022
411 Glycine N-methyltransferase GNMT 0.0022
298 Renin REN 0.0021
6506 Stathmin-4 STMN4 0.0021
174 Sigma 1-type opioid receptor SIGMAR1 0.0021
5294 Nucleoside diphosphate kinase A NME1 0.0021
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0021
594 Thyroxine-binding globulin SERPINA7 0.0021
3601 Dihydropteroate synthase 1 folP1 0.0021
3807 Dihydropteroate synthase 1 folP1 0.0021
3808 Dihydropteroate synthase 2 folP2 0.0021
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0021
162 Retinoic acid receptor gamma-1 RARG 0.002
369 Coagulation factor VII F7 0.002
719 Retinoic acid receptor responder protein 1 RARRES1 0.002
770 Retinoic acid-induced protein 3 GPRC5A 0.002
5934 Cytochrome P450 26A1 CYP26A1 0.002
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.002
293 Gamma-glutamyl hydrolase GGH 0.002
3856 Fibroblast growth factor receptor 3 FGFR3 0.002
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.002
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.002
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.002
273 Apoptosis regulator Bcl-2 BCL2 0.002
3929 Phosphoethanolamine/phosphocholine phosphatase PHOSPHO1 0.0019
3926 Choline transporter-like protein 2 SLC44A2 0.0019
4226 Uridine phosphorylase 2 UPP2 0.0019
3925 Choline transporter-like protein 4 SLC44A4 0.0019
549 Choline-phosphate cytidylyltransferase B PCYT1B 0.0019
3933 Choline/ethanolaminephosphotransferase CEPT1 0.0019
3927 Choline transporter-like protein 3 SLC44A3 0.0019
1686 Choline transporter-like protein 1 SLC44A1 0.0019
5787 Angiopoietin-1 receptor TEK 0.0019
633 Penicillin-binding proteins 1A/1B pbpA 0.0019
861 Choline kinase alpha CHKA 0.0019
769 High-affinity choline transporter 1 SLC5A7 0.0019
700 Choline dehydrogenase, mitochondrial CHDH 0.0019
264 Choline/ethanolamine kinase [Includes: Choline kinase beta CHKB 0.0019
576 Choline O-acetyltransferase CHAT 0.0019
3922 Phospholipase D2 PLD2 0.0019
3924 Phospholipase D1 PLD1 0.0019
3913 Glutamic acid decarboxylase GAD65 0.0019
5682 Ribonuclease pancreatic RNASE1 0.0019
718 Folate receptor gamma FOLR3 0.0019
299 Folate receptor beta FOLR2 0.0019
804 Mitochondrial folate transporter/carrier SLC25A32 0.0019
6459 Glycodelin PAEP 0.0019
4311 tRNA TRDMT1 0.0019
4325 tRNA trmD 0.0019
4328 tRNA trmD 0.0019
758 Thyroid hormone receptor alpha THRA 0.0019
1074 Urokinase-type plasminogen activator PLAU 0.0019
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0019
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0019
3957 Adenosine deaminase ADA 0.0019
6131 Carbonic anhydrase 14 CA14 0.0019
291 Nitric-oxide synthase, endothelial NOS3 0.0019
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0018
2112 Toll-like receptor 9 TLR9 0.0018
5998 Toll-like receptor 8 TLR8 0.0018
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0018
712 Tubulin alpha chain TUB1 0.0018
1968 ATP-sensitive inward rectifier potassium channel 12 KCNJ12 0.0018
5923 Microtubule-associated protein tau MAPT 0.0018
5924 Microtubule-associated protein 4 MAP4 0.0018
565 Extracellular calcium-sensing receptor CASR 0.0018
4225 Uridine phosphorylase 1 UPP1 0.0018
569 Retinal dehydrogenase 2 ALDH1A2 0.0018
1650 Heme carrier protein 1 SLC46A1 0.0018
6122 Carbonic anhydrase 3 CA3 0.0018
277 Purine nucleoside phosphorylase PNP 0.0018
2870 Purine nucleoside phosphorylase punA 0.0018
2945 Purine nucleoside phosphorylase punA 0.0018
4659 Purine nucleoside phosphorylase TM_1596 0.0018
4825 Purine nucleoside phosphorylase TTHA1435 0.0018
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.0017
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.0017
543 Penicillin-binding protein 1B mrcB 0.0017
6186 Penicillin-binding protein 1B ponB 0.0017
6822 Penicillin-binding protein 1b pbp1b 0.0017
6844 Penicillin-binding protein 1b pbp1b 0.0017
346 Thyroid hormone receptor beta-1 THRB 0.0017
159 Penicillin-binding protein 2B penA 0.0017
6121 Penicillin-binding protein 2B penA 0.0017
144 Hemoglobin subunit alpha HBA1 0.0017
611 Retinal dehydrogenase 1 ALDH1A1 0.0017
459 Retinoic acid receptor RXR-alpha RXRA 0.0017
413 Amidophosphoribosyltransferase PPAT 0.0017
2515 Amidophosphoribosyltransferase purF 0.0017
3714 Amidophosphoribosyltransferase purF 0.0017
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0016
735 Alanine aminotransferase 1 GPT 0.0016
3904 Alanine aminotransferase 2 GPT2 0.0016
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0016
173 Toll-like receptor 7 TLR7 0.0016
3238 Multidrug resistance protein mexA mexA 0.0016
3709 Glycerol uptake facilitator protein glpF 0.0016
3116 Bacterioferritin bfr 0.0016
4906 Bacterioferritin bfr 0.0016
4965 Bacterioferritin bfr 0.0016
5489 Ribonucleoside-diphosphate reductase 1 subunit beta nrdB 0.0016
3173 Enolase eno 0.0016
3336 C4-dicarboxylate transport transcriptional regulatory protein dctD dctD 0.0016
3393 TGF-beta receptor type-2 TGFBR2 0.0016
1039 Histone deacetylase 9 HDAC9 0.0016
3233 Bile acid receptor NR1H4 0.0015
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0015
2408 Tyrosine-protein kinase SYK SYK 0.0015
6755 Poliovirus receptor PVR 0.0015
936 Ephrin type-A receptor 2 EPHA2 0.0015
1291 cAMP response element-binding protein CREB1 0.0015
581 Cytochrome P450 2R1 CYP2R1 0.0015
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0015
1525 Heparin-binding growth factor 2 FGF2 0.0015
1569 G1/S-specific cyclin-D1 CCND1 0.0015
634 Squalene monooxygenase SQLE 0.0014
7196 Squalene monooxygenase ERG1 0.0014
1541 Metalloproteinase mmp20 0.0014
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0014
268 Adenosine A2b receptor ADORA2B 0.0014
4210 Toll-like receptor 4 TLR4 0.0014
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0014
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0014
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0014
1760 Aminopeptidase N ANPEP 0.0014
6843 Aminopeptidase N pepN 0.0014
2129 Sucrase-isomaltase, intestinal SI 0.0014
3221 Cytochrome c4 cc4 0.0014
1262 Corticotropin-lipotropin POMC 0.0014
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.0014
117 Sterol O-acyltransferase 1 SOAT1 0.0014
2852 DNA mismatch repair protein mutL mutL 0.0014
3639 Thymidine phosphorylase deoA 0.0014
3936 Thymidine phosphorylase TYMP 0.0014
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0014
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0014
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0013
3191 Histidinol dehydrogenase hisD 0.0013
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0013
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0013
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0013
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0013
199 Monocarboxylate transporter 8 SLC16A2 0.0013
6116 Gastric triacylglycerol lipase LIPF 0.0012
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0012
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0012
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0012
4692 A/G-specific adenine glycosylase mutY 0.0012
3382 Glycolipid transfer protein GLTP 0.0012
2240 Cell division protein kinase 2 CDK2 0.0012
85 Growth hormone receptor GHR 0.0012
1714 Mitogen-activated protein kinase 3 MAPK3 0.0012
2297 Genome polyprotein Not Available 0.0012
2322 Genome polyprotein Not Available 0.0012
2694 Genome polyprotein Not Available 0.0012
2719 Genome polyprotein Not Available 0.0012
2860 Genome polyprotein Not Available 0.0012
2928 Genome polyprotein Not Available 0.0012
3160 Genome polyprotein Not Available 0.0012
3260 Genome polyprotein Not Available 0.0012
4783 Genome polyprotein Not Available 0.0012
5726 Genome polyprotein Not Available 0.0012
5779 Genome polyprotein Not Available 0.0012
5867 Genome polyprotein Not Available 0.0012
6253 Genome polyprotein Not Available 0.0012
6301 Genome polyprotein Not Available 0.0012
6380 Genome polyprotein Not Available 0.0012
6381 Genome polyprotein Not Available 0.0012
6437 Genome polyprotein Not Available 0.0012
6520 Genome polyprotein Not Available 0.0012
6521 Genome polyprotein Not Available 0.0012
6652 Genome polyprotein Not Available 0.0012
6734 Genome polyprotein Not Available 0.0012
6735 Genome polyprotein Not Available 0.0012
6736 Genome polyprotein Not Available 0.0012
6737 Genome polyprotein Not Available 0.0012
6738 Genome polyprotein Not Available 0.0012
6739 Genome polyprotein Not Available 0.0012
6744 Genome polyprotein Not Available 0.0012
6748 Genome polyprotein Not Available 0.0012
6894 Genome polyprotein Not Available 0.0012
6898 Genome polyprotein Not Available 0.0012
571 Melatonin receptor type 1A MTNR1A 0.0012
362 Melatonin receptor type 1B MTNR1B 0.0012
338 DNA polymerase UL30 0.0012
379 DNA polymerase UL54 0.0012
697 DNA polymerase ORF28 0.0012
2482 DNA polymerase 43 0.0012
4104 DNA polymerase BALF5 0.0012
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0012
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0012
1295 Fatty acid synthase FASN 0.0012
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0012
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0012
6859 Protein S100-A4 S100A4 0.0012
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0012
707 72 kDa type IV collagenase MMP2 0.0011
484 Tyrosine-protein kinase ABL2 ABL2 0.0011
754 Pancreatic triacylglycerol lipase PNLIP 0.0011
2236 Casein kinase II subunit alpha CSNK2A1 0.0011
2802 Endoglucanase G celCCG 0.0011
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0011
1630 Integrin beta-2 ITGB2 0.0011
6316 ADP-ribosylation factor 1 ARF1 0.0011
1810 Protein S100-A1 S100A1 0.001
6097 Protein S100-A2 S100A2 0.001
4228 Keratin, type II cytoskeletal 7 KRT7 0.001
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.001
1063 Signal transducer and activator of transcription 5B STAT5B 0.001
2216 Fibroblast growth factor receptor 4 FGFR4 0.001
1144 Hepatocyte growth factor receptor MET 0.001
3007 Carbonic anhydrase 12 CA12 0.001
4205 Carbonic anhydrase 9 CA9 0.001
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.001
493 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial CYP27B1 0.001
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.001
2101 Glutathione-requiring prostaglandin D synthase HPGDS 0.001
512 DNA-directed RNA polymerase alpha chain rpoA 0.001
5772 DNA-directed RNA polymerase alpha chain rpoA 0.001
4041 Microsomal glutathione S-transferase 2 MGST2 0.001
1176 Mitogen-activated protein kinase 1 MAPK1 0.001
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.001
2473 Tyrosine-protein kinase CSK CSK 0.001
2398 Tyrosine-protein kinase ZAP-70 ZAP70 0.001
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.001
2268 Cholesterol oxidase choB 0.0009
2822 Cholesterol oxidase choA 0.0009
997 Protein kinase C beta type PRKCB 0.0009
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0009
6048 Troponin C, skeletal muscle TNNC2 0.0009
6105 3-oxo-5-beta-steroid 4-dehydrogenase AKR1D1 0.0009
3086 Plasmepsin-2 Not Available 0.0009
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0009
1048 Protein S100-A13 S100A13 0.0009
2226 Protein S100-A12 S100A12 0.0009
1648 Elastin ELN 0.0009
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0009
2283 Steroid Delta-isomerase ksi 0.0009
2920 Steroid Delta-isomerase ksi 0.0009
1970 Protein kinase C alpha type PRKCA 0.0009
992 Protein tyrosine kinase 2 beta PTK2B 0.0009
6044 Serum paraoxonase/lactonase 3 PON3 0.0009
208 DNA-directed RNA polymerase beta' chain rpoC 0.0009
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0009
2132 Protein S100-B S100B 0.0009
22 30S ribosomal protein S4 rpsD 0.0008
6714 30S ribosomal protein S4 rpsD 0.0008
2325 Sulfotransferase family cytosolic 2B member 1 SULT2B1 0.0008
3616 Fatty acid-binding protein, epidermal FABP5 0.0008
5433 UPF0230 protein TM_1468 TM_1468 0.0008
5430 Hepatocyte nuclear factor 4-gamma HNF4G 0.0008
5431 Lipid binding protein Not Available 0.0008
572 Integrin alpha-L ITGAL 0.0008
5798 Mitogen-activated protein kinase 11 MAPK11 0.0008
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0008
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0008
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0008
229 Retinoic acid receptor beta RARB 0.0008
1867 Major prion protein PRNP 0.0008
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0008
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0008
2232 Interleukin-5 IL5 0.0008
1593 Mucin-2 MUC2 0.0008
4031 Glutathione S-transferase A1 GSTA1 0.0008
730 Retinoic acid receptor alpha RARA 0.0008
1649 Small inducible cytokine A2 CCL2 0.0008
2530 Protein kinase C theta type PRKCQ 0.0008
1025 Aquaporin-1 AQP1 0.0008
2091 Endoplasmin HSP90B1 0.0008
760 Fibroblast growth factor 1 FGF1 0.0007
130 Prostacyclin synthase PTGIS 0.0007
6103 Arylamine N-acetyltransferase 1 NAT1 0.0007
6207 30S ribosomal protein S14 rpsN 0.0007
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0007
6209 30S ribosomal protein S19 rpsS 0.0007
6712 30S ribosomal protein S19 rpsS 0.0007
6726 30S ribosomal protein S19 rpsS 0.0007
283 SEC14-like protein 2 SEC14L2 0.0007
6151 Monocarboxylate transporter 10 SLC16A10 0.0007
645 Penicillin-binding protein 1A mrcA 0.0007
5805 Penicillin-binding protein 1A ponA 0.0007
6185 Penicillin-binding protein 1A mrcA 0.0007
6799 Penicillin-binding protein 1A pbpA 0.0007
3587 Gastrotropin FABP6 0.0007
2511 MAP kinase-activated protein kinase 2 MAPKAPK2 0.0007
226 Gonadotropin-releasing hormone receptor GNRHR 0.0007
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.0007
6837 Serine/threonine-protein kinase 17B STK17B 0.0007
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0007
5432 Trafficking protein particle complex subunit 3 TRAPPC3 0.0007
2211 Fatty acid-binding protein, heart FABP3 0.0007
1123 Eosinophil cationic protein RNASE3 0.0007
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0006
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0006
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0006
33 Cystine/glutamate transporter SLC7A11 0.0006
6228 Nuclear receptor coactivator 1 NCOA1 0.0006
6677 Myelin P2 protein PMP2 0.0006
6241 Nuclear receptor coactivator 2 NCOA2 0.0006
1196 Complement decay-accelerating factor CD55 0.0006
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0006
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0006
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0006
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.0006
6168 Solute carrier family 22 member 16 SLC22A16 0.0006
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.0006
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0006
1721 Glycogen synthase kinase-3 beta GSK3B 0.0005
2808 Chloramphenicol acetyltransferase 3 cat3 0.0005
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0005
2021 Thrombomodulin THBD 0.0005
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0005
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0005
2183 Fatty acid-binding protein, adipocyte FABP4 0.0005
2417 Chloramphenicol acetyltransferase cat 0.0005
3278 Chloramphenicol acetyltransferase cat 0.0005
2810 Dr hemagglutinin structural subunit draA 0.0005
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0005
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.0005
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.0005
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.0005
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0004
1992 Vitamin D-binding protein GC 0.0004
76 Nitric-oxide synthase, brain NOS1 0.0004
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.0004
6042 Prostaglandin reductase 2 PTGR2 0.0004
5818 Folate receptor alpha FOLR1 0.0004
340 Apoptotic protease-activating factor 1 APAF1 0.0004
2391 Ferrochelatase hemH 0.0004
6502 Ferrochelatase DKFZp686P18130 0.0004
1591 Ferrochelatase, mitochondrial FECH 0.0004
1792 Tissue-type plasminogen activator PLAT 0.0004
825 Arsenical pump-driving ATPase ASNA1 0.0003
3435 Arsenical pump-driving ATPase arsA 0.0003
486 Serine/threonine-protein kinase ALS2CR7 CDK15 0.0003
2105 ATP-binding cassette sub-family G member 1 ABCG1 0.0003
377 Beta-adrenergic receptor kinase 1 ADRBK1 0.0003
510 Serine/threonine-protein kinase receptor R3 ACVRL1 0.0003
733 Activin receptor type 1B ACVR1B 0.0003
225 NEDD8-activating enzyme E1 regulatory subunit NAE1 0.0003
745 Anti-Muellerian hormone type-2 receptor AMHR2 0.0003
483 A-Raf proto-oncogene serine/threonine-protein kinase ARAF 0.0003
21 Beta-adrenergic receptor kinase 2 ADRBK2 0.0003
154 AFG3-like protein 2 AFG3L2 0.0003
395 ALK tyrosine kinase receptor Not Available 0.0003
6496 Cytochrome c oxidase subunit 8A, mitochondrial COX8A 0.0003
6493 Cytochrome c oxidase subunit 6C COX6C 0.0003
6495 Cytochrome c oxidase subunit 7C, mitochondrial COX7C 0.0003
6499 Cytochrome c oxidase polypeptide 7A1, mitochondrial COX7A1 0.0003
6494 Cytochrome c oxidase subunit 7B, mitochondrial COX7B 0.0003
6491 Cytochrome c oxidase subunit 5A, mitochondrial COX5A 0.0003
6498 Cytochrome c oxidase subunit 6B1 COX6B1 0.0003
6497 Cytochrome c oxidase subunit 6A2, mitochondrial COX6A2 0.0003
6489 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial COX4I1 0.0003
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.0003
6559 Cytochrome c oxidase subunit 2 ctaC 0.0003
6669 Cytochrome c oxidase subunit 2 ctaC 0.0003
6490 Cytochrome c oxidase subunit 3 MT-CO3 0.0003
371 Cytochrome c oxidase subunit 1 MT-CO1 0.0003
6558 Cytochrome c oxidase subunit 1 ctaD 0.0003
292 Activin receptor type-1 ACVR1 0.0003
849 Activated CDC42 kinase 1 TNK2 0.0003
1313 Lactoylglutathione lyase GLO1 0.0003
267 Plasminogen activator inhibitor 1 SERPINE1 0.0003
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0003
2540 Choloylglycine hydrolase cbh 0.0003
704 Long-chain-fatty-acid--CoA ligase 1 ACSL1 0.0003
821 Acetyl-coenzyme A synthetase 2-like, mitochondrial ACSS1 0.0003
386 Acetyl-coenzyme A synthetase, cytoplasmic ACSS2 0.0003
297 Adenylate cyclase type 1 ADCY1 0.0003
289 Cytosolic purine 5'-nucleotidase NT5C2 0.0003
6501 Fatty acid-binding protein, liver FABP1 0.0003
6221 Steroid hormone receptor ERR1 ESRRA 0.0003
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0003
740 Argininosuccinate synthase ASS1 0.0002
865 Argininosuccinate synthase ASS1 0.0002
2680 Argininosuccinate synthase argG 0.0002
3194 Argininosuccinate synthase argG 0.0002
661 ADP/ATP translocase 1 SLC25A4 0.0002
6021 Adenosine kinase ADK 0.0002
242 Asparagine synthetase [glutamine-hydrolyzing] ASNS 0.0002
6500 Phospholipase A2 PLA2G1B 0.0002
6135 Sodium channel subunit beta-4 SCN4B 0.0002
6134 Sodium channel subunit beta-3 SCN3B 0.0002
6132 Sodium channel subunit beta-1 SCN1B 0.0002
6127 Carbonic anhydrase-related protein CA8 0.0002
6128 Carbonic anhydrase-related protein 10 CA10 0.0002
6133 Sodium channel subunit beta-2 SCN2B 0.0002
6129 Carbonic anhydrase-related protein 11 CA11 0.0002
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0002
6130 Carbonic anhydrase 13 CA13 0.0002
4936 Cytochrome c2 iso-2 Not Available 0.0001
4916 Cyanoglobin glbN 0.0001
4994 Hemoglobin-like protein HbO glbO 0.0001
4915 Cytochrome c-550 psbV 0.0001
4959 Cytochrome c-550 psbV 0.0001
5216 Cytochrome c-550 psbV 0.0001
4925 Cytochrome c-type protein SHP shp 0.0001
4904 Cytochrome c family protein GSU1996 0.0001
4943 Cytochrome c6 petJ 0.0001
4954 Soluble cytochrome b558 Not Available 0.0001
4934 Cytochrome c-551 nirM 0.0001
5218 Cytochrome c-551 nirM 0.0001
4905 Cytochrome c2 Not Available 0.0001
4939 Cytochrome c2 cycA 0.0001
4964 Cytochrome c2 cycA 0.0001
4979 Cytochrome c2 cycA 0.0001
6673 Cytochrome c2 cycA 0.0001
4910 Cytoglobin CYGB 0.0001
4984 Neuroglobin NGB 0.0001
4981 Iron-starvation protein PigA pigA 0.0001
4909 CooA protein cooA 0.0001
4998 Hemoglobin-like protein yjbI yjbI 0.0001
4935 Cytochrome c-554 cycA1 0.0001
4947 Bacterial hemoglobin vhb 0.0001
4975 Cytochrome c-556 RPA3973 0.0001
4942 Diheme cytochrome c napB napB 0.0001
4931 Cytochrome P450 167A1 CYP167A1 0.0001
5000 HemO hemO 0.0001
4972 P450cin cinA 0.0001
4960 Putative cytochrome P450-family protein SCO7417 0.0001
4971 Nonaheme cytochrome c hmcA 0.0001
4989 Cytochrome c551 peroxidase ccp 0.0001
5222 Cytochrome c551 peroxidase ccpA 0.0001
4961 Hemophore HasA hasA 0.0001
4976 Apocytochrome f petA 0.0001
6407 Apocytochrome f petA 0.0001
4907 Cytochrome c-L moxG 0.0001
6865 Cytochrome c-L moxG 0.0001
4993 Hydroxylamine oxidoreductase hao1 0.0001
4764 Cytochrome P450 165C4 CYP165C4 0.0001
4926 Heme-based aerotactic transducer hemAT hemAT 0.0001
644 Heme oxygenase 2 HMOX2 0.0001
4982 Heme oxygenase 2 pbsA2 0.0001
4952 Catalase/peroxidase katA 0.0001
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0001
4937 Cytochrome oxidase subunit II rcoxA 0.0001
4903 Methyl-accepting chemotaxis protein Tar4 0.0001
4999 Cytochrome P450 165B3 CYP165B3 0.0001
3093 Catalase HPII katE 0.0001
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0001
4922 Cytochrome c, putative SO_4144 0.0001
4920 Peroxidase/catalase katG 0.0001
4990 PpcA ppcA 0.0001
4948 Cytochrome c-553 Not Available 0.0001
4923 Cytochrome c3 DvMF_2499 0.0001
4945 Cytochrome c3 Not Available 0.0001
4949 Cytochrome c3 DVU_3171 0.0001
4968 Cytochrome c3 cytc3 0.0001
4997 Cytochrome c3 SO_2727 0.0001
5219 Cytochrome c3 cyd 0.0001
2119 Cytochrome b5 CYB5A 0.0001
4902 Nine-heme cytochrome c Ddes_2038 0.0001
3189 High-molecular-weight cytochrome c hmcA 0.0001
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0001
3375 Acidic cytochrome c3 Not Available 0.0001
4988 Sulfite oxidase, mitochondrial SUOX 0.0001
2915 Sensor protein fixL fixL 0.0001
4944 Sensor protein fixL fixL 0.0001
4813 Heme oxygenase hmuO 0.0001
5769 Heme oxygenase Not Available 0.0001
3570 Cytochrome P450 152A1 cypC 0.0001
4385 Cytochrome c' Not Available 0.0001
4967 Cytochrome c' cycA 0.0001
5038 Cytochrome c' Not Available 0.0001
5223 Cytochrome c' cycP 0.0001
4037 Hypothetical protein GPX1 0.0001
4297 Hypothetical protein SP_1951 0.0001
4521 Hypothetical protein BC_2969 0.0001
4540 Hypothetical protein TM_1070 0.0001
4555 Hypothetical protein MT1739 0.0001
4569 Hypothetical protein mshD 0.0001
4578 Hypothetical protein PA3270 0.0001
4747 Hypothetical protein PA3967 0.0001
5177 Hypothetical protein TM_0096 0.0001
5194 Hypothetical protein PA1204 0.0001
5240 Hypothetical protein Rv2991 0.0001
5370 Hypothetical protein TM_1158 0.0001
5710 Hypothetical protein Tb927.5.1360 0.0001
4289 Cytochrome P450 TT_P0059 0.0001
6262 Cytochrome P450 staP 0.0001
4992 Cytochrome c peroxidase Not Available 0.0001
3670 Soluble cytochrome b562 precursor cybC 0.0001
3411 Cytochrome P450 121 cyp121 0.0001
3291 Cytochrome c-552 cycA 0.0001
4927 Cytochrome c-552 nrfA 0.0001
4938 Cytochrome c-552 cycA 0.0001
4953 Cytochrome c-552 nrfA 0.0001
5217 Cytochrome c-552 cycM 0.0001
2617 Nitric oxide synthase oxygenase nos 0.0001
2701 Nitric oxide synthase oxygenase nos 0.0001
3102 Flavohemoprotein hmp 0.0001
4969 Flavohemoprotein hmp 0.0001
4386 Hemoglobin-like protein HbN glbN 0.0001
3127 Nitrite reductase nirS 0.0001
3284 Nitrite reductase nirS 0.0001
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0001
2972 6-deoxyerythronolide B hydroxylase eryF 0.0001
4608 Putative cytochrome P450 SCO1207 0.0001
4963 Putative cytochrome P450 SCO2884 0.0001
6254 Putative cytochrome P450 SCO6998 0.0001
1507 Cytochrome c CYCS 0
693 Hemoglobin subunit beta HBB 0
6268 Hydroxyacid oxidase 1 HAO1 0
810 Heme oxygenase 1 HMOX1 0
3391 Heme oxygenase 1 pbsA1 0