DT-Web

DB01100 - Pimozide


Identification
Name Pimozide
Accession Number DB01100 (APRD00218)
Type small molecule
Description A diphenylbutylpiperidine that is effective as an antipsychotic agent and as an alternative to haloperidol for the suppression of vocal and motor tics in patients with Tourette syndrome. Although the precise mechanism of action is unknown, blockade of postsynaptic dopamine receptors has been postulated. (From AMA Drug Evaluations Annual, 1994, p403)
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 461.5462
Groups approved
Monoisotopic Weight 461.227868975
Pharmacology
Indication Used for the suppression of motor and phonic tics in patients with Tourette's Disorder who have failed to respond satisfactorily to standard treatment.
Mechanism of action The ability of pimozide to suppress motor and phonic tics in Tourette's Disorder is thought to be primarily a function of its dopaminergic blocking activity. Pimozide binds and inhibits the dopamine D2 receptor in the CNS.
Absorption Greater than 50% absorption after oral administration. Serum peak appears 6-8 hours post ingestion.
Protein binding Not Available
Biotransformation Notable first-pass metabolism in the liver, primarily by N-dealkylation via the cytochrome P450 isoenzymes CYP3A and CYP1A2 (and possibly CYP2D6). The activity of the two major metabolites has not been determined.
Route of elimination Not Available
Toxicity LD50 = 1100 mg/kg (rat, oral), 228 mg/kg (mouse, oral)
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Amprenavir Amprenavir may increase the effect and toxicity of pimozide.
Aprepitant Increased risk of cardiotoxicity and arrhythmias
Artemether Additive QTc-prolongation may occur. Concomitant therapy is contraindicated.
Atazanavir The protease inhibitor, atazanavir, may increase the effect and toxicity of pimozide.
Boceprevir Boceprevir increases levels by affecting CYP3A4 metabolism. Concomitant therapy is contraindicated.
Citalopram The SSRI, citalopram, may increase the effect and toxicity of pimozide.
Clarithromycin Increased risk of cardiotoxicity and arrhythmias
Donepezil Possible antagonism of action
Erythromycin Increased risk of cardiotoxicity and arrhythmias
Escitalopram The SSRI, escitalopram, increases the effect and toxicity of pimozide.
Fluconazole Increased risk of cardiotoxicity and arrhythmias
Fosamprenavir Amprenavir increases the effect and toxicity of pimozide
Galantamine Possible antagonism of action
Imatinib Imatinib may increase the effect and toxicity of pimozide.
Indinavir The protease inhibitor, indinavir, may increase the effect and toxicity of pimozide.
Itraconazole Increased risk of cardiotoxicity and arrhythmias
Josamycin Increased risk of cardiotoxicity and arrhythmias
Ketoconazole Increased risk of cardiotoxicity and arrhythmias
Lumefantrine Additive QTc-prolongation may occur. Concomitant therapy is contraindicated.
Mesoridazine Increased risk of cardiotoxicity and arrhythmias
Nefazodone Nefazodone may increase the effect and toxicity of pimozide.
Nelfinavir Nelfinavir increases the effect and toxicity of pimozide
Paroxetine Increased risk of cardiotoxicity and arrhythmias.
Posaconazole Contraindicated co-administration
Ritonavir The protease inhibitor, ritonavir, may increase the effect and toxicity of pimozide.
Rivastigmine Possible antagonism of action
Saquinavir The protease inhibitor, saquinavir, may increase the effect and toxicity of pimozide.
Sertraline The SSRI, sertraline, increases the effect and toxicity of pimozide.
Tacrine The therapeutic effects of the central acetylcholinesterase inhibitor (AChEI), Tacrine, and/or the anticholinergic/antipsychotic, Pimozide, may be reduced due to antagonism. This interaction may be beneficial when the anticholinergic action is a side effect. AChEIs may also augment the central neurotoxic effect of antipsychotics. Monitor for extrapyramidal symptoms and decreased efficacy of both agents.
Tacrolimus Additive QTc-prolongation may occur increasing the risk of serious ventricular arrhythmias. Concomitant therapy should be used with caution.
Telaprevir Telaprevir increases levels by affecting CYP3A4 metabolism. Concomitant therapy is contraindicated.
Telavancin Additive QTc-prolongation may occur. Concomitant therapy should be avoided.
Telithromycin Telithromycin may reduce clearance of Pimozide. Concomitant therapy is contraindicated.
Tetrabenazine May cause dopamine deficiency. Monitor for Tetrabenazine adverse effects.
Thioridazine Increased risk of cardiotoxicity and arrhythmias
Thiothixene May cause additive QTc-prolonging effects. Increased risk of ventricular arrhythmias. Consider alternate therapy. Thorough risk:benefit assessment is required prior to co-administration.
Ticlopidine Avoid combination with pimozide and other major CYP3A4 substrates due to the potential increase of pimozide concentration.
Tipranavir Tipranavir, co-administered with Ritonavir, may increase the plasma concentration of Pimozide. Concomitant therapy is contraindicated.
Toremifene Additive QTc-prolongation may occur, increasing the risk of serious ventricular arrhythmias. Consider alternate therapy. A thorough risk:benefit assessment is required prior to co-administration.
Trimethobenzamide Trimethobenzamide and Pimozide, two anticholinergics, may cause additive anticholinergic effects and enhance their adverse/toxic effects. Monitor for enhanced anticholinergic effects.
Trimipramine Additive QTc-prolongation may occur, increasing the risk of serious ventricular arrhythmias. Concomitant therapy should be used with caution.
Triprolidine Triprolidine and Pimozide, two anticholinergics, may cause additive anticholinergic effects and enhance their adverse/toxic effects. Additive CNS depressant effects may also occur. Monitor for enhanced anticholinergic and CNS depressant effects.
Troleandomycin Increased risk of cardiotoxicity and arrhythmias
Trospium Trospium and Pimozide, two anticholinergics, may cause additive anticholinergic effects and enhanced adverse/toxic effects. Monitor for enhanced anticholinergic effects.
Voriconazole Voriconazole, a strong CYP3A4 inhibitor, may increase the serum concentration of pimozide by decreasing its metabolism. Increased risk of QTc prolongation and development arrhythmias. Concomitant use is contraindicated.
Vorinostat Additive QTc prolongation may occur. Concomitant therapy is contraindicated.
Zileuton Increased risk of cardiotoxicity and arrhythmias
Ziprasidone Additive QTc-prolonging effects may increase the risk of severe arrhythmias. Concomitant therapy should be avoided.
Zuclopenthixol Additive QTc-prolonging effects increases risk of cardiac arrhythmias. Concomitant therapy is contraindicated.
Food Interactions
  • Take without regard to meals.
  • Grapefruit and grapefruit juice should be avoided throughout treatment. Grapefruit can increase serum levels of this product.

Targets


D(2) dopamine receptor
Name D(2) dopamine receptor
Gene Name DRD2
Pharmacological action yes
Actions antagonist
References
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
  • Seeman P: Atypical antipsychotics: mechanism of action. Can J Psychiatry. 2002 Feb;47(1):27-38. - Pubmed
  • Silva MR, Bernardi MM, Cruz-Casallas PE, Felicio LF: Pimozide injections into the Nucleus accumbens disrupt maternal behaviour in lactating rats. Pharmacol Toxicol. 2003 Jul;93(1):42-7. - Pubmed
  • Muscat R, Sampson D, Willner P: Dopaminergic mechanism of imipramine action in an animal model of depression. Biol Psychiatry. 1990 Aug 1;28(3):223-30. - Pubmed
  • Zarrindast MR, Heidari MR: On the mechanisms by which theophylline changes core body temperature in mice. Eur J Pharmacol. 1994 May 12;257(1-2):13-20. - Pubmed
  • Freedman SB, Patel S, Marwood R, Emms F, Seabrook GR, Knowles MR, McAllister G: Expression and pharmacological characterization of the human D3 dopamine receptor. J Pharmacol Exp Ther. 1994 Jan;268(1):417-26. - Pubmed
  • Cusack B, Nelson A, Richelson E: Binding of antidepressants to human brain receptors: focus on newer generation compounds. Psychopharmacology (Berl). 1994 May;114(4):559-65. - Pubmed
  • Murphy LL, Adrian BA, Kohli M: Inhibition of luteinizing hormone secretion by delta9-tetrahydrocannabinol in the ovariectomized rat: effect of pretreatment with neurotransmitter or neuropeptide receptor antagonists. Steroids. 1999 Sep;64(9):664-71. - Pubmed
DTHybrid score 0.3921
D(3) dopamine receptor
Name D(3) dopamine receptor
Gene Name DRD3
Pharmacological action yes
Actions antagonist
References
  • Freedman SB, Patel S, Marwood R, Emms F, Seabrook GR, Knowles MR, McAllister G: Expression and pharmacological characterization of the human D3 dopamine receptor. J Pharmacol Exp Ther. 1994 Jan;268(1):417-26. - Pubmed
DTHybrid score 0.2047
Potassium voltage-gated channel subfamily H member 2
Name Potassium voltage-gated channel subfamily H member 2
Gene Name KCNH2
Pharmacological action yes
Actions inhibitor
References
  • Kang J, Wang L, Cai F, Rampe D: High affinity blockade of the HERG cardiac K(+) channel by the neuroleptic pimozide. Eur J Pharmacol. 2000 Mar 31;392(3):137-40. - Pubmed
  • Osypenko VM, Degtiar VIe, Naid'onov VG, Shuba IaM: [Blockade of HERG K+ channels expressed in Xenopus oocytes by antipsychotic agents] Fiziol Zh. 2001;47(1):17-25. - Pubmed
  • Shuba YM, Degtiar VE, Osipenko VN, Naidenov VG, Woosley RL: Testosterone-mediated modulation of HERG blockade by proarrhythmic agents. Biochem Pharmacol. 2001 Jul 1;62(1):41-9. - Pubmed
  • Kang J, Chen XL, Rampe D: The antipsychotic drugs sertindole and pimozide block erg3, a human brain K(+) channel. Biochem Biophys Res Commun. 2001 Aug 24;286(3):499-504. - Pubmed
DTHybrid score 0.2236
Calmodulin
Name Calmodulin
Gene Name CALM1
Pharmacological action unknown
Actions inhibitor
References
  • Papadopoulos V, Brown AS, Hall PF: Calcium-calmodulin-dependent phosphorylation of cytoskeletal proteins from adrenal cells. Mol Cell Endocrinol. 1990 Dec 3;74(2):109-23. - Pubmed
  • Wang XB, Sato N, Greer MA, Greer SE, McAdams S: Role of extracellular calcium and calmodulin in prolactin secretion induced by hyposmolarity, thyrotropin-releasing hormone, and high K+ in GH4C1 cells. Acta Endocrinol (Copenh). 1990 Aug;123(2):218-24. - Pubmed
  • Strobl JS, Kirkwood KL, Lantz TK, Lewine MA, Peterson VA, Worley JF 3rd: Inhibition of human breast cancer cell proliferation in tissue culture by the neuroleptic agents pimozide and thioridazine. Cancer Res. 1990 Sep 1;50(17):5399-405. - Pubmed
  • Cimino M, Weiss B: Characteristics of the binding of phenoxybenzamine to calmodulin. Biochem Pharmacol. 1988 Jul 15;37(14):2739-45. - Pubmed
  • Mody I, Baimbridge KG, Miller JJ: Blockade of tetanic- and calcium-induced long-term potentiation in the hippocampal slice preparation by neuroleptics. Neuropharmacology. 1984 Jun;23(6):625-31. - Pubmed
DTHybrid score 0.4166

Enzymes


Cytochrome P450 3A5
Name Cytochrome P450 3A5
Gene Name CYP3A5
Actions substrate
References
DTHybrid score 0.4899
Cytochrome P450 3A7
Name Cytochrome P450 3A7
Gene Name CYP3A7
Actions substrate
References
DTHybrid score 0.3892
Cytochrome P450 3A4
Name Cytochrome P450 3A4
Gene Name CYP3A4
Actions substrate,inhibitor
References
  • Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.8666
Cytochrome P450 1A2
Name Cytochrome P450 1A2
Gene Name CYP1A2
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.5461
Cytochrome P450 2C19
Name Cytochrome P450 2C19
Gene Name CYP2C19
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.4726
Cytochrome P450 2D6
Name Cytochrome P450 2D6
Gene Name CYP2D6
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.6901
Cytochrome P450 2E1
Name Cytochrome P450 2E1
Gene Name CYP2E1
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.3473

Transporters


Multidrug resistance protein 1
Name Multidrug resistance protein 1
Gene Name ABCB1
Actions inhibitor
References
  • Schwab D, Fischer H, Tabatabaei A, Poli S, Huwyler J: Comparison of in vitro P-glycoprotein screening assays: recommendations for their use in drug discovery. J Med Chem. 2003 Apr 24;46(9):1716-25. - Pubmed
  • Ibrahim S, Peggins J, Knapton A, Licht T, Aszalos A: Influence of antipsychotic, antiemetic, and Ca(2+) channel blocker drugs on the cellular accumulation of the anticancer drug daunorubicin: P-glycoprotein modulation. J Pharmacol Exp Ther. 2000 Dec;295(3):1276-83. - Pubmed
DTHybrid score 0.5554

Predictions


Id Partner name Gene Name Score
4757 Cytochrome P450 2C9 CYP2C9 0.4051
4924 Cytochrome P450 2C8 CYP2C8 0.2958
6030 Cytochrome P450 2B6 CYP2B6 0.2337
502 5-hydroxytryptamine 2A receptor HTR2A 0.2038
23 D(1A) dopamine receptor DRD1 0.181
6024 Cytochrome P450 1A1 CYP1A1 0.1784
556 Alpha-1A adrenergic receptor ADRA1A 0.1567
492 Histamine H1 receptor HRH1 0.133
5718 Cytochrome P450 2A6 CYP2A6 0.1329
320 5-hydroxytryptamine 1A receptor HTR1A 0.1235
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.113
587 Serum albumin ALB 0.1117
432 D(4) dopamine receptor DRD4 0.111
590 5-hydroxytryptamine 2C receptor HTR2C 0.1109
318 Alpha-2A adrenergic receptor ADRA2A 0.1066
632 Alpha-1B adrenergic receptor ADRA1B 0.1053
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0951
629 Alpha-2B adrenergic receptor ADRA2B 0.0924
378 Alpha-2C adrenergic receptor ADRA2C 0.0898
6145 Solute carrier family 22 member 1 SLC22A1 0.0888
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0869
824 Sodium-dependent serotonin transporter SLC6A4 0.0847
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0812
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0809
163 D(1B) dopamine receptor DRD5 0.0799
20 Prostaglandin G/H synthase 1 PTGS1 0.0773
885 5-hydroxytryptamine 1B receptor HTR1B 0.0772
725 5-hydroxytryptamine 1D receptor HTR1D 0.0763
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0715
766 Beta-2 adrenergic receptor ADRB2 0.0713
6106 Cytochrome P450 2C18 CYP2C18 0.0711
789 Alpha-1D adrenergic receptor ADRA1D 0.0705
193 Beta-1 adrenergic receptor ADRB1 0.0696
6144 Solute carrier family 22 member 2 SLC22A2 0.0682
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0682
862 Multidrug resistance-associated protein 1 ABCC1 0.0676
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0676
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0676
716 5-hydroxytryptamine 7 receptor HTR7 0.0631
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0619
3811 Cytochrome P450 19A1 CYP19A1 0.0602
436 5-hydroxytryptamine 2B receptor HTR2B 0.0586
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0583
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0567
3923 Cholinesterase BCHE 0.0567
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0557
1898 Cytochrome P450 1B1 CYP1B1 0.0555
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0549
847 Mu-type opioid receptor OPRM1 0.0538
1729 Solute carrier family 22 member 6 SLC22A6 0.0495
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0492
817 DNA topoisomerase 2-alpha TOP2A 0.0487
341 5-hydroxytryptamine 3 receptor HTR3A 0.0483
776 Bile salt export pump ABCB11 0.0482
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0464
713 Sodium-dependent dopamine transporter SLC6A3 0.0446
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0446
118 Organic cation/carnitine transporter 2 SLC22A5 0.0435
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0429
260 Cytochrome P450 51 ERG11 0.0428
761 Cytochrome P450 51 ERG11 0.0428
3163 Cytochrome P450 51 cyp51 0.0428
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0426
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0425
871 Glucocorticoid receptor NR3C1 0.0421
1256 5-hydroxytryptamine 6 receptor HTR6 0.0419
6031 Cytochrome P450 3A43 CYP3A43 0.0416
6182 Cytochrome P450 2J2 CYP2J2 0.0406
467 Delta-type opioid receptor OPRD1 0.0403
3941 Amine oxidase [flavin-containing] A MAOA 0.0402
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0399
6147 Solute carrier family 22 member 3 SLC22A3 0.0386
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0385
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.038
290 Prostaglandin G/H synthase 2 PTGS2 0.0371
696 Kappa-type opioid receptor OPRK1 0.037
731 HIV-1 protease HIV-1 protease 0.0369
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0361
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.036
1507 Cytochrome c CYCS 0.0356
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0356
722 Troponin I, cardiac muscle TNNI3 0.0347
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0346
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0344
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0343
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0341
136 Estrogen receptor ESR1 0.0335
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0332
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0324
3939 Amine oxidase [flavin-containing] B MAOB 0.0315
6143 Solute carrier family 22 member 7 SLC22A7 0.0313
6142 Solute carrier family 22 member 8 SLC22A8 0.0305
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0304
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0302
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0295
833 Organic cation/carnitine transporter 1 SLC22A4 0.029
233 Potassium channel subfamily K member 2 KCNK2 0.0289
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0282
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0281
2164 Multidrug resistance-associated protein 4 ABCC4 0.0276
1968 ATP-sensitive inward rectifier potassium channel 12 KCNJ12 0.027
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0266
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0266
468 Cytochrome P450 4A11 CYP4A11 0.0263
36 Insulin receptor INSR 0.0258
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0258
6148 Multidrug resistance-associated protein 7 ABCC10 0.0248
94 5-hydroxytryptamine 4 receptor HTR4 0.0245
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0237
477 DNA topoisomerase 4 subunit A parC 0.0236
886 DNA topoisomerase 4 subunit A parC 0.0236
6226 DNA topoisomerase 4 subunit A parC 0.0236
404 DNA gyrase subunit A gyrA 0.0233
6224 DNA gyrase subunit A gyrA 0.0233
614 Progesterone receptor PGR 0.023
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0229
528 5-hydroxytryptamine 1E receptor HTR1E 0.0227
3947 Xanthine dehydrogenase/oxidase XDH 0.0225
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0223
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.022
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.022
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0218
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0218
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0218
124 Histamine H2 receptor HRH2 0.0217
174 Sigma 1-type opioid receptor SIGMAR1 0.0215
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0214
737 Mineralocorticoid receptor NR3C2 0.021
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0207
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0207
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0204
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0203
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0202
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0201
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0199
442 Envelope glycoprotein gp41 0.0198
4859 Envelope glycoprotein env 0.0198
777 Tumor necrosis factor TNF 0.0198
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0197
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0193
6048 Troponin C, skeletal muscle TNNC2 0.0192
705 Glutamate receptor 1 GRIA1 0.019
380 Cytochrome P450 17A1 CYP17A1 0.0189
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0188
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0185
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0184
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0184
4148 Serine/threonine-protein kinase mTOR MTOR 0.0183
844 Epidermal growth factor receptor EGFR 0.0182
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0182
4604 Liver carboxylesterase 1 CES1 0.0181
16 Adenosine A1 receptor ADORA1 0.018
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0177
6220 Aryl hydrocarbon receptor AHR 0.0175
811 Translocator protein TSPO 0.017
1089 Cartilage oligomeric matrix protein COMP 0.0168
1108 Calpastatin CAST 0.0168
232 Corticosteroid-binding globulin SERPINA6 0.0166
3086 Plasmepsin-2 Not Available 0.0166
504 Mast/stem cell growth factor receptor KIT 0.0166
818 50S ribosomal protein L10 rplJ 0.0165
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0164
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0164
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0163
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0163
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0163
122 P2Y purinoceptor 12 P2RY12 0.0163
1178 Adenosine A2a receptor ADORA2A 0.0163
756 Sex hormone-binding globulin SHBG 0.0161
6859 Protein S100-A4 S100A4 0.0161
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.016
474 Acetylcholinesterase ACHE 0.0159
751 Potassium channel subfamily K member 6 KCNK6 0.0158
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0158
146 Androgen receptor AR 0.0156
1010 Cytochrome P450 51A1 CYP51A1 0.0155
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0155
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0154
161 Tubulin beta chain TUBB 0.0154
312 Tubulin beta chain TUB2 0.0154
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0154
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0153
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0153
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0153
482 Glycine receptor subunit alpha-1 GLRA1 0.0153
26 Vascular endothelial growth factor receptor 3 FLT4 0.0152
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0152
131 Synaptic vesicular amine transporter SLC18A2 0.0146
2392 Biphenyl-2,3-diol 1,2-dioxygenase bphC 0.0146
3032 Biphenyl-2,3-diol 1,2-dioxygenase bphC 0.0146
32 Vascular endothelial growth factor receptor 1 FLT1 0.0145
172 Potassium channel subfamily K member 1 KCNK1 0.0144
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0142
427 Substance-P receptor TACR1 0.0142
228 Beta platelet-derived growth factor receptor PDGFRB 0.014
6137 Multidrug resistance-associated protein 6 ABCC6 0.0139
407 Vascular endothelial growth factor receptor 2 KDR 0.0139
571 Melatonin receptor type 1A MTNR1A 0.0138
362 Melatonin receptor type 1B MTNR1B 0.0138
1757 Myeloperoxidase MPO 0.0138
537 ATP synthase delta chain, mitochondrial ATP5D 0.0136
6141 Sodium/bile acid cotransporter SLC10A1 0.0135
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0132
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0132
6136 Multidrug resistance-associated protein 5 ABCC5 0.0131
4120 NADPH--cytochrome P450 reductase POR 0.0131
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.013
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0129
1656 CYP2B protein CYP2B 0.0128
1024 Solute carrier family 22 member 11 SLC22A11 0.0127
6102 Arylamine N-acetyltransferase 2 NAT2 0.0127
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0126
596 3-oxo-5-alpha-steroid 4-dehydrogenase 1 SRD5A1 0.0126
29 Tubulin beta-1 chain TUBB1 0.0126
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0125
869 Estrogen receptor beta ESR2 0.0124
921 Glutamate receptor 2 GRIA2 0.0124
952 Dipeptidyl peptidase 4 DPP4 0.0124
2314 Triosephosphate isomerase TPI 0.0123
3417 Triosephosphate isomerase tpiA 0.0123
3443 Triosephosphate isomerase tpiA 0.0123
6346 Triosephosphate isomerase TPI1 0.0123
6014 Cytochrome P450 2A13 CYP2A13 0.0123
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.012
153 Dopamine beta-hydroxylase DBH 0.0119
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0118
2795 Methionine aminopeptidase 2 METAP2 0.0117
4122 Histone deacetylase 2 HDAC2 0.0115
642 3-oxo-5-alpha-steroid 4-dehydrogenase 2 SRD5A2 0.0115
1192 Sulfotransferase 1A1 SULT1A1 0.0113
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.0113
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0113
768 FK506-binding protein 1A FKBP1A 0.0112
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0112
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0111
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.011
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0109
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.0109
6020 Aldehyde oxidase AOX1 0.0107
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0106
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0106
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0106
613 Atrial natriuretic peptide receptor A NPR1 0.0106
723 Cytosolic phospholipase A2 PLA2G4A 0.0106
373 Transthyretin TTR 0.0106
4237 50S ribosomal protein L22 rplV 0.0106
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0105
2132 Protein S100-B S100B 0.0105
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0104
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0104
5682 Ribonuclease pancreatic RNASE1 0.0104
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0104
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0104
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0104
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0103
70 Type-1 angiotensin II receptor AGTR1 0.0103
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0099
183 Vascular endothelial growth factor A VEGFA 0.0099
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0098
2539 Tubulin alpha-1 chain TUBA4A 0.0098
958 Insulin-like growth factor 1 receptor IGF1R 0.0097
273 Apoptosis regulator Bcl-2 BCL2 0.0095
4238 50S ribosomal protein L4 rplD 0.0094
5578 50S ribosomal protein L4 rplD 0.0094
6173 50S ribosomal protein L4 rplD 0.0094
6219 50S ribosomal protein L4 rplD 0.0094
1374 Natriuretic peptides B NPPB 0.0093
1827 Gap junction alpha-1 protein GJA1 0.0093
1908 Vascular cell adhesion protein 1 VCAM1 0.0093
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0092
3810 Catechol O-methyltransferase COMT 0.0092
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0091
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.009
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.009
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.009
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0089
1517 Beta-3 adrenergic receptor ADRB3 0.0089
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0088
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0087
814 Ryanodine receptor 1 RYR1 0.0087
1262 Corticotropin-lipotropin POMC 0.0087
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0086
165 FL cytokine receptor FLT3 0.0084
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0083
319 Opioid receptor, sigma 1 OPRS1 0.0083
295 Carbonic anhydrase 1 CA1 0.0083
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0082
239 Coagulation factor X F10 0.0082
866 Large neutral amino acids transporter small subunit 2 SLC7A8 0.0082
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0082
6432 Transporter snf 0.0082
592 Carbonic anhydrase 4 CA4 0.0081
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0081
565 Extracellular calcium-sensing receptor CASR 0.008
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.008
2112 Toll-like receptor 9 TLR9 0.008
1353 DNA topoisomerase 1 TOP1 0.008
3552 DNA topoisomerase 1 topA 0.008
1852 Microtubule-associated protein 2 MAP2 0.0079
891 Dihydropteroate synthase folP 0.0079
5359 Dihydropteroate synthase folP 0.0079
7175 Dihydropteroate synthase sulI 0.0079
823 Fibroblast growth factor receptor 2 FGFR2 0.0079
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0079
173 Toll-like receptor 7 TLR7 0.0079
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0078
365 Dihydrofolate reductase DHFR 0.0078
2381 Dihydrofolate reductase DFR1 0.0078
2833 Dihydrofolate reductase Not Available 0.0078
2931 Dihydrofolate reductase folA 0.0078
3544 Dihydrofolate reductase folA 0.0078
3682 Dihydrofolate reductase folA 0.0078
6642 Dihydrofolate reductase folA 0.0078
6756 Dihydrofolate reductase dfrA 0.0078
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0077
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.0077
244 Angiotensin-converting enzyme ACE 0.0076
2449 Tubulin alpha-3 chain TUBA1A 0.0076
904 Glutathione S-transferase P GSTP1 0.0075
738 Monocarboxylate transporter 1 SLC16A1 0.0075
284 DNA-directed RNA polymerase beta chain rpoB 0.0074
5773 DNA-directed RNA polymerase beta chain rpoB 0.0074
923 Glutamate receptor 3 GRIA3 0.0074
1050 Bile salt sulfotransferase SULT2A1 0.0074
208 DNA-directed RNA polymerase beta' chain rpoC 0.0074
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0074
469 Annexin A1 ANXA1 0.0073
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0073
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0072
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0072
5300 Antigen peptide transporter 1 TAP1 0.0072
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0071
4311 tRNA TRDMT1 0.0071
4325 tRNA trmD 0.0071
4328 tRNA trmD 0.0071
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0071
790 DNA polymerase subunit alpha B POLA2 0.0071
1483 Membrane copper amine oxidase AOC3 0.0071
3830 Calreticulin CALR 0.0071
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0071
1618 High affinity nerve growth factor receptor NTRK1 0.007
976 Platelet glycoprotein IX GP9 0.007
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.007
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.007
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.007
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.007
511 5-hydroxytryptamine 1F receptor HTR1F 0.007
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.007
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.007
3932 Glutathione S-transferase A2 GSTA2 0.0069
6044 Serum paraoxonase/lactonase 3 PON3 0.0068
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0068
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0067
6035 Nuclear receptor ROR-beta RORB 0.0067
6034 Hydroxyindole O-methyltransferase ASMT 0.0067
6036 Eosinophil peroxidase EPX 0.0066
6766 O-GlcNAcase BT_4395 BT_4395 0.0066
2499 Tubulin beta-2C chain TUBB2C 0.0065
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0064
2616 Ganglioside GM2 activator GM2A 0.0063
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0063
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0063
3432 Multidrug-efflux transporter 1 regulator bmrR 0.0063
4476 Mannitol dehydrogenase mtlD 0.0063
444 Alcohol dehydrogenase 1B ADH1B 0.0063
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0063
7 Nitric oxide synthase, inducible NOS2 0.0062
6105 3-oxo-5-beta-steroid 4-dehydrogenase AKR1D1 0.0062
6151 Monocarboxylate transporter 10 SLC16A10 0.0062
6138 Multidrug resistance protein 3 ABCB4 0.0062
518 Peroxidase/catalase T katG 0.0061
357 Carbonic anhydrase 2 CA2 0.0061
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.006
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.006
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.006
6085 Fatty acid-binding protein, intestinal FABP2 0.006
185 Vasopressin V1a receptor AVPR1A 0.006
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0059
3601 Dihydropteroate synthase 1 folP1 0.0059
3807 Dihydropteroate synthase 1 folP1 0.0059
3808 Dihydropteroate synthase 2 folP2 0.0059
251 Alcohol dehydrogenase 1A ADH1A 0.0059
5923 Microtubule-associated protein tau MAPT 0.0059
5924 Microtubule-associated protein 4 MAP4 0.0059
322 Vasopressin V2 receptor AVPR2 0.0058
765 Indoleamine 2,3-dioxygenase IDO1 0.0058
6126 Carbonic anhydrase 7 CA7 0.0058
68 Cannabinoid receptor 1 CNR1 0.0058
563 Thyroid peroxidase TPO 0.0058
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0057
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0057
84 Nuclear receptor 0B1 NR0B1 0.0057
164 Histamine H4 receptor HRH4 0.0057
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0057
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0056
1629 Transcription factor AP-1 JUN 0.0056
3913 Glutamic acid decarboxylase GAD65 0.0055
4203 Histamine N-methyltransferase HNMT 0.0055
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0055
6506 Stathmin-4 STMN4 0.0055
1196 Complement decay-accelerating factor CD55 0.0055
4773 Deoxycytidine kinase DCK 0.0055
65 Matrix metalloproteinase-9 Not Available 0.0054
390 Adenosine A3 receptor ADORA3 0.0053
275 Arachidonate 5-lipoxygenase ALOX5 0.0053
5998 Toll-like receptor 8 TLR8 0.0053
54 Prothrombin F2 0.0053
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0052
49 Endothelin B receptor EDNRB 0.0052
712 Tubulin alpha chain TUB1 0.0052
3090 Chitosanase csn 0.0052
4149 Nuclear factor NF-kappa-B p100 subunit NFKB2 0.0052
3823 Cytokine receptor common gamma chain IL2RG 0.0051
694 Matrix protein 2 M 0.0051
33 Cystine/glutamate transporter SLC7A11 0.005
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.005
4192 DNA topoisomerase 2-beta TOP2B 0.005
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.005
1630 Integrin beta-2 ITGB2 0.005
4103 Proteasome subunit beta type 2 PSMB2 0.005
4102 Proteasome subunit beta type 5 PSMB5 0.005
4101 Proteasome subunit beta type 1 PSMB1 0.005
578 Endothelin-1 receptor EDNRA 0.0049
6043 Putative G-protein coupled receptor 44 GPR44 0.0049
3404 Exotoxin A eta 0.0049
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0048
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.0048
3856 Fibroblast growth factor receptor 3 FGFR3 0.0048
2808 Chloramphenicol acetyltransferase 3 cat3 0.0047
517 Alcohol dehydrogenase 1C ADH1C 0.0047
856 Vitamin D3 receptor VDR 0.0047
683 Potassium transporter GK0582 0.0047
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0046
1770 Phospholipase C PLCL1 0.0046
2841 Phospholipase C plc 0.0046
3904 Alanine aminotransferase 2 GPT2 0.0046
735 Alanine aminotransferase 1 GPT 0.0046
1525 Heparin-binding growth factor 2 FGF2 0.0046
1253 Interferon gamma IFNG 0.0046
4228 Keratin, type II cytoskeletal 7 KRT7 0.0046
6174 50S ribosomal protein L32 rpmF 0.0045
3957 Adenosine deaminase ADA 0.0045
634 Squalene monooxygenase SQLE 0.0045
7196 Squalene monooxygenase ERG1 0.0045
724 Interleukin-2 receptor alpha chain IL2RA 0.0045
717 Interleukin-2 receptor subunit beta IL2RB 0.0045
2178 Metabotropic glutamate receptor 5 GRM5 0.0045
3809 Estrogen-related receptor gamma ESRRG 0.0045
908 Glutathione S-transferase theta-1 GSTT1 0.0044
780 Retinoic acid receptor RXR-gamma RXRG 0.0044
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0044
4116 Dihydropteroate synthetase Not Available 0.0044
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0044
117 Sterol O-acyltransferase 1 SOAT1 0.0043
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0043
2230 Catalase CAT 0.0043
3249 Catalase katA 0.0043
3625 Catalase katA 0.0043
4539 Catalase katA 0.0043
4941 Catalase katB 0.0043
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0043
2417 Chloramphenicol acetyltransferase cat 0.0043
3278 Chloramphenicol acetyltransferase cat 0.0043
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0043
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0043
6146 High affinity copper uptake protein 1 SLC31A1 0.0043
2810 Dr hemagglutinin structural subunit draA 0.0043
473 L-lactate dehydrogenase A chain LDHA 0.0042
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0042
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0042
714 Glutathione reductase, mitochondrial GSR 0.0042
1864 RET proto-oncogene RET 0.0042
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0041
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0041
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0041
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0041
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0041
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0041
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0041
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0041
3937 Fatty-acid amide hydrolase FAAH 0.0041
3997 Cytochrome P450 24A1, mitochondrial CYP24A1 0.0041
88 Retinoic acid receptor RXR-beta RXRB 0.004
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.004
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.004
291 Nitric-oxide synthase, endothelial NOS3 0.004
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0039
2268 Cholesterol oxidase choB 0.0039
2822 Cholesterol oxidase choA 0.0039
2290 ADP-ribosyl cyclase 2 BST1 0.0039
1129 C-C chemokine receptor type 5 CCR5 0.0039
605 Fumarate reductase flavoprotein subunit frdA 0.0038
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0038
3673 Fumarate reductase flavoprotein subunit fccA 0.0038
4912 Fumarate reductase flavoprotein subunit ifcA 0.0038
6549 Fumarate reductase flavoprotein subunit frdA 0.0038
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0038
6824 Tyrosine-protein kinase Lyn LYN 0.0038
5934 Cytochrome P450 26A1 CYP26A1 0.0038
85 Growth hormone receptor GHR 0.0038
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0037
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0037
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0037
572 Integrin alpha-L ITGAL 0.0037
992 Protein tyrosine kinase 2 beta PTK2B 0.0037
2283 Steroid Delta-isomerase ksi 0.0037
2920 Steroid Delta-isomerase ksi 0.0037
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0036
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0036
633 Penicillin-binding proteins 1A/1B pbpA 0.0036
543 Penicillin-binding protein 1B mrcB 0.0035
6186 Penicillin-binding protein 1B ponB 0.0035
6822 Penicillin-binding protein 1b pbp1b 0.0035
6844 Penicillin-binding protein 1b pbp1b 0.0035
5787 Angiopoietin-1 receptor TEK 0.0035
2300 Lysozyme E 0.0035
3633 Lysozyme R 0.0035
5597 Lysozyme 17 0.0035
159 Penicillin-binding protein 2B penA 0.0035
6121 Penicillin-binding protein 2B penA 0.0035
939 50S ribosomal protein L3 rplC 0.0035
6755 Poliovirus receptor PVR 0.0034
936 Ephrin type-A receptor 2 EPHA2 0.0034
2325 Sulfotransferase family cytosolic 2B member 1 SULT2B1 0.0034
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0034
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0034
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0034
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0033
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0032
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0032
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0032
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0032
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0032
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0032
2107 Microtubule-associated protein 1A MAP1A 0.0032
24 Thymidylate synthase TMP1 0.0032
359 Thymidylate synthase TYMS 0.0032
2626 Thymidylate synthase thyA 0.0032
2729 Thymidylate synthase thyA 0.0032
5352 Thymidylate synthase THYA 0.0032
581 Cytochrome P450 2R1 CYP2R1 0.0032
140 30S ribosomal protein S9 rpsI 0.0031
6719 30S ribosomal protein S9 rpsI 0.0031
6725 30S ribosomal protein S9 rpsI 0.0031
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0031
1636 Trace amine-associated receptor 1 TAAR1 0.0031
3917 Methylenetetrahydrofolate reductase MTHFR 0.0031
4210 Toll-like receptor 4 TLR4 0.0031
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0031
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0031
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0031
162 Retinoic acid receptor gamma-1 RARG 0.003
2578 Tubulin beta-3 chain TUBB3 0.003
1650 Heme carrier protein 1 SLC46A1 0.003
2285 Streptogramin A acetyltransferase vatD 0.003
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.003
106 Cannabinoid receptor 2 CNR2 0.003
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.003
1360 Sphingomyelin phosphodiesterase SMPD1 0.0029
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0029
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0029
512 DNA-directed RNA polymerase alpha chain rpoA 0.0029
5772 DNA-directed RNA polymerase alpha chain rpoA 0.0029
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0029
1435 Synaptic vesicle glycoprotein 2A SV2A 0.0028
330 Spermidine synthase SRM 0.0028
3038 Spermidine synthase speE 0.0028
6149 Solute carrier family 22 member 10 SLC22A10 0.0028
820 Glycine receptor subunit alpha-2 GLRA2 0.0028
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0028
1063 Signal transducer and activator of transcription 5B STAT5B 0.0028
6232 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short GNAS 0.0027
6233 Adenylate cyclase type 2 ADCY2 0.0027
6234 Adenylate cyclase type 5 ADCY5 0.0027
2298 Cytochrome P450-cam camC 0.0027
2297 Genome polyprotein Not Available 0.0027
2322 Genome polyprotein Not Available 0.0027
2694 Genome polyprotein Not Available 0.0027
2719 Genome polyprotein Not Available 0.0027
2860 Genome polyprotein Not Available 0.0027
2928 Genome polyprotein Not Available 0.0027
3160 Genome polyprotein Not Available 0.0027
3260 Genome polyprotein Not Available 0.0027
4783 Genome polyprotein Not Available 0.0027
5726 Genome polyprotein Not Available 0.0027
5779 Genome polyprotein Not Available 0.0027
5867 Genome polyprotein Not Available 0.0027
6253 Genome polyprotein Not Available 0.0027
6301 Genome polyprotein Not Available 0.0027
6380 Genome polyprotein Not Available 0.0027
6381 Genome polyprotein Not Available 0.0027
6437 Genome polyprotein Not Available 0.0027
6520 Genome polyprotein Not Available 0.0027
6521 Genome polyprotein Not Available 0.0027
6652 Genome polyprotein Not Available 0.0027
6734 Genome polyprotein Not Available 0.0027
6735 Genome polyprotein Not Available 0.0027
6736 Genome polyprotein Not Available 0.0027
6737 Genome polyprotein Not Available 0.0027
6738 Genome polyprotein Not Available 0.0027
6739 Genome polyprotein Not Available 0.0027
6744 Genome polyprotein Not Available 0.0027
6748 Genome polyprotein Not Available 0.0027
6894 Genome polyprotein Not Available 0.0027
6898 Genome polyprotein Not Available 0.0027
4173 Tyrosine-protein kinase JAK2 JAK2 0.0027
267 Plasminogen activator inhibitor 1 SERPINE1 0.0027
6167 Organic solute transporter subunit beta OSTB 0.0027
6166 Organic solute transporter subunit alpha OSTA 0.0027
144 Hemoglobin subunit alpha HBA1 0.0027
3849 Insulin-like growth factor-binding protein 7 IGFBP7 0.0027
2009 Protein NOV homolog NOV 0.0027
3847 Neuroendocrine convertase 2 PCSK2 0.0027
1949 Carboxypeptidase E CPE 0.0027
3850 Synaptotagmin-like protein 4 SYTL4 0.0027
3848 Neuroendocrine convertase 1 PCSK1 0.0027
3846 Retinoblastoma-associated protein RB1 0.0027
1275 Estrogen sulfotransferase SULT1E1 0.0027
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0026
2216 Fibroblast growth factor receptor 4 FGFR4 0.0026
6599 HTH-type transcriptional regulator ttgR ttgR 0.0026
268 Adenosine A2b receptor ADORA2B 0.0026
1648 Elastin ELN 0.0026
5997 Tumor necrosis factor ligand superfamily member 11 TNFSF11 0.0026
6316 ADP-ribosylation factor 1 ARF1 0.0026
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0025
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0025
484 Tyrosine-protein kinase ABL2 ABL2 0.0025
6228 Nuclear receptor coactivator 1 NCOA1 0.0025
1385 Angiotensin-converting enzyme 2 ACE2 0.0025
5880 Thrombopoietin receptor MPL 0.0025
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0025
459 Retinoic acid receptor RXR-alpha RXRA 0.0025
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0024
5432 Trafficking protein particle complex subunit 3 TRAPPC3 0.0024
334 S-adenosylmethionine synthetase isoform type-2 MAT2A 0.0024
544 Potassium voltage-gated channel subfamily E member 1 KCNE1 0.0024
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0024
6221 Steroid hormone receptor ERR1 ESRRA 0.0024
6039 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A PDE11A 0.0024
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0024
6070 Nischarin NISCH 0.0024
719 Retinoic acid receptor responder protein 1 RARRES1 0.0024
5852 Type-2 angiotensin II receptor AGTR2 0.0024
770 Retinoic acid-induced protein 3 GPRC5A 0.0024
4221 Vascular endothelial growth factor VEGF 0.0023
5816 Cadherin-5 CDH5 0.0023
550 Amiloride-sensitive sodium channel subunit delta SCNN1D 0.0023
27 Amiloride-sensitive sodium channel subunit beta SCNN1B 0.0023
552 Amiloride-sensitive sodium channel subunit gamma SCNN1G 0.0023
213 Amiloride-sensitive sodium channel subunit alpha SCNN1A 0.0023
1830 5'-nucleotidase NT5E 0.0023
358 Cystathionine beta-synthase CBS 0.0023
896 Glutathione S-transferase Mu 1 GSTM1 0.0023
453 S-adenosylmethionine synthetase isoform type-1 MAT1A 0.0023
6131 Carbonic anhydrase 14 CA14 0.0023
2599 Tyrosine-protein kinase HCK HCK 0.0022
1714 Mitogen-activated protein kinase 3 MAPK3 0.0022
2981 Phospholipase A2, membrane associated PLA2G2A 0.0022
707 72 kDa type IV collagenase MMP2 0.0022
113 S-adenosylmethionine decarboxylase proenzyme AMD1 0.0022
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0022
394 Calcineurin subunit B isoform 1 PPP3R1 0.0022
6742 Recoverin RCVRN 0.0022
6752 Guanylyl cyclase-activating protein 1 GUCA1A 0.0022
2528 Fatty acid metabolism regulator protein fadR 0.0022
6740 Fatty acid metabolism regulator protein fadR 0.0022
6753 Apolipoprotein M APOM 0.0022
6747 Chalcone/stilbene synthase family protein MT1417 0.0022
6741 Peroxisomal 3,2-trans-enoyl-CoA isomerase PECI 0.0022
6743 Non-fluorescent flavoprotein luxF 0.0022
6751 Gag polyprotein gag 0.0022
6746 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform PPP3CA 0.0022
6522 Hepatocyte nuclear factor 4-alpha HNF4A 0.0022
6749 Polyprotein Not Available 0.0022
686 Aldo-keto reductase family 1 member C2 AKR1C2 0.0022
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.0022
411 Glycine N-methyltransferase GNMT 0.0022
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0022
2155 Insulin-degrading enzyme IDE 0.0022
298 Renin REN 0.0021
6122 Carbonic anhydrase 3 CA3 0.0021
2091 Endoplasmin HSP90B1 0.0021
6211 Tubulin epsilon chain TUBE1 0.0021
6212 Tubulin gamma-1 chain TUBG1 0.0021
6210 Tubulin delta chain TUBD1 0.0021
1244 Low-density lipoprotein receptor-related protein 2 LRP2 0.0021
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0021
569 Retinal dehydrogenase 2 ALDH1A2 0.0021
63 Malate dehydrogenase mdh 0.0021
2329 Malate dehydrogenase mdh 0.0021
3445 Malate dehydrogenase mdh 0.0021
4420 Malate dehydrogenase mdh 0.0021
4438 Malate dehydrogenase mdh 0.0021
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0021
594 Thyroxine-binding globulin SERPINA7 0.0021
400 Coagulation factor IX F9 0.0021
5461 Coagulation factor IX F9 0.0021
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.002
1992 Vitamin D-binding protein GC 0.002
293 Gamma-glutamyl hydrolase GGH 0.002
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.002
1820 Beta-nerve growth factor NGF 0.002
1039 Histone deacetylase 9 HDAC9 0.002
5961 Insulin INS 0.002
2236 Casein kinase II subunit alpha CSNK2A1 0.0019
611 Retinal dehydrogenase 1 ALDH1A1 0.0019
718 Folate receptor gamma FOLR3 0.0019
299 Folate receptor beta FOLR2 0.0019
804 Mitochondrial folate transporter/carrier SLC25A32 0.0019
461 Glycine receptor subunit alpha-3 GLRA3 0.0019
6163 Copper-transporting ATPase 2 ATP7B 0.0019
6165 Copper-transporting ATPase 1 ATP7A 0.0019
6527 Lymphocyte antigen 96 LY96 0.0019
6459 Glycodelin PAEP 0.0019
758 Thyroid hormone receptor alpha THRA 0.0019
4081 Vitamin K epoxide reductase complex subunit 1-like protein 1 VKORC1L1 0.0019
604 Vitamin K-dependent protein Z PROZ 0.0019
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0019
3426 Glutamine synthetase glnA 0.0019
3987 Glutamine synthetase GLUL 0.0019
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0018
558 Solute carrier family 12 member 1 SLC12A1 0.0018
4217 Telomerase reverse transcriptase TERT 0.0018
893 [Citrate [pro-3S]-lyase] ligase citC 0.0018
845 Pyruvate dehydrogenase [cytochrome] poxB 0.0018
5626 Nucleoside diphosphate kinase B NME2 0.0018
327 Glutathione reductase gor 0.0018
5110 Glutathione reductase GR2 0.0018
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0018
6750 ADP-ribosylation factor 6 ARF6 0.0018
6524 Protein tonB tonB 0.0018
4373 Medium-chain-fatty-acid--CoA ligase Not Available 0.0018
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.0017
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.0017
229 Retinoic acid receptor beta RARB 0.0017
422 Vitamin K-dependent protein C PROC 0.0017
1245 Vitamin K-dependent protein S PROS1 0.0017
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0017
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0017
760 Fibroblast growth factor 1 FGF1 0.0017
346 Thyroid hormone receptor beta-1 THRB 0.0017
730 Retinoic acid receptor alpha RARA 0.0017
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0017
78 Acetyl-CoA acetyltransferase, mitochondrial ACAT1 0.0016
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.0016
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0016
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0016
1268 Neuropeptide S receptor NPSR1 0.0016
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0016
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0016
2207 Rhodopsin RHO 0.0016
2435 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase lpxC 0.0016
6613 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase lpxC 0.0016
1243 Cathepsin D CTSD 0.0016
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0016
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0016
3238 Multidrug resistance protein mexA mexA 0.0016
3709 Glycerol uptake facilitator protein glpF 0.0016
3116 Bacterioferritin bfr 0.0016
4906 Bacterioferritin bfr 0.0016
4965 Bacterioferritin bfr 0.0016
5489 Ribonucleoside-diphosphate reductase 1 subunit beta nrdB 0.0016
3173 Enolase eno 0.0016
3336 C4-dicarboxylate transport transcriptional regulatory protein dctD dctD 0.0016
3393 TGF-beta receptor type-2 TGFBR2 0.0016
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0016
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0015
3233 Bile acid receptor NR1H4 0.0015
2408 Tyrosine-protein kinase SYK SYK 0.0015
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0015
448 Vitamin K-dependent gamma-carboxylase GGCX 0.0015
702 UMP-CMP kinase CMPK1 0.0015
982 Cocaine- and amphetamine-regulated transcript protein CARTPT 0.0015
3611 Cytidine deaminase cdd 0.0015
3707 Cytidine deaminase cdd 0.0015
4211 Cytidine deaminase CDA 0.0015
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0015
828 Phenylalanine-4-hydroxylase PAH 0.0015
3109 Phenylalanine-4-hydroxylase phhA 0.0015
1291 cAMP response element-binding protein CREB1 0.0015
3844 HLA class II histocompatibility antigen, DQ(6) alpha chain HLA-DQA2 0.0015
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0015
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0015
6073 Potassium channel subfamily K member 9 KCNK9 0.0015
6072 Potassium channel subfamily K member 3 KCNK3 0.0015
5294 Nucleoside diphosphate kinase A NME1 0.0015
1569 G1/S-specific cyclin-D1 CCND1 0.0015
5798 Mitogen-activated protein kinase 11 MAPK11 0.0014
1541 Metalloproteinase mmp20 0.0014
864 Gag-Pol polyprotein gag-pol 0.0014
2237 Gag-Pol polyprotein gag-pol 0.0014
2326 Gag-Pol polyprotein gag-pol 0.0014
2451 Gag-Pol polyprotein gag-pol 0.0014
2901 Gag-Pol polyprotein gag-pol 0.0014
3165 Gag-Pol polyprotein gag-pol 0.0014
3722 Gag-Pol polyprotein gag-pol 0.0014
6306 Gag-Pol polyprotein gag-pol 0.0014
6624 Gag-Pol polyprotein gag-pol 0.0014
2320 Thymidine kinase, cytosolic TK1 0.0014
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0014
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0014
1760 Aminopeptidase N ANPEP 0.0014
6843 Aminopeptidase N pepN 0.0014
2129 Sucrase-isomaltase, intestinal SI 0.0014
798 Osteocalcin BGLAP 0.0014
3221 Cytochrome c4 cc4 0.0014
1341 Histamine H3 receptor HRH3 0.0014
2852 DNA mismatch repair protein mutL mutL 0.0014
3007 Carbonic anhydrase 12 CA12 0.0014
4205 Carbonic anhydrase 9 CA9 0.0014
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0013
3191 Histidinol dehydrogenase hisD 0.0013
6241 Nuclear receptor coactivator 2 NCOA2 0.0013
199 Monocarboxylate transporter 8 SLC16A2 0.0013
6218 Pannexin-1 PANX1 0.0013
369 Coagulation factor VII F7 0.0013
860 Nicotinamide N-methyltransferase NNMT 0.0013
699 Nicotinic acid receptor 1 GPR109A 0.0013
928 Nicotinic acid receptor 2 GPR109B 0.0013
583 Nicotinate-nucleotide pyrophosphorylase [carboxylating] QPRT 0.0013
2442 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
2459 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0013
6116 Gastric triacylglycerol lipase LIPF 0.0012
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0012
4692 A/G-specific adenine glycosylase mutY 0.0012
3382 Glycolipid transfer protein GLTP 0.0012
2427 Ferrichrome-iron receptor fhuA 0.0012
2240 Cell division protein kinase 2 CDK2 0.0012
338 DNA polymerase UL30 0.0012
379 DNA polymerase UL54 0.0012
697 DNA polymerase ORF28 0.0012
2482 DNA polymerase 43 0.0012
4104 DNA polymerase BALF5 0.0012
489 Monocarboxylate transporter 2 SLC16A7 0.0012
2021 Thrombomodulin THBD 0.0012
1295 Fatty acid synthase FASN 0.0012
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0012
6264 cAMP-dependent protein kinase inhibitor alpha PKIA 0.0011
754 Pancreatic triacylglycerol lipase PNLIP 0.0011
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0011
2802 Endoglucanase G celCCG 0.0011
1810 Protein S100-A1 S100A1 0.001
6097 Protein S100-A2 S100A2 0.001
1144 Hepatocyte growth factor receptor MET 0.001
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.001
493 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial CYP27B1 0.001
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.001
2101 Glutathione-requiring prostaglandin D synthase HPGDS 0.001
4041 Microsomal glutathione S-transferase 2 MGST2 0.001
1176 Mitogen-activated protein kinase 1 MAPK1 0.001
2473 Tyrosine-protein kinase CSK CSK 0.001
2398 Tyrosine-protein kinase ZAP-70 ZAP70 0.001
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.001
997 Protein kinase C beta type PRKCB 0.0009
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0009
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0009
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0009
6168 Solute carrier family 22 member 16 SLC22A16 0.0009
1064 DNA (cytosine-5)-methyltransferase 1 DNMT1 0.0009
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0009
1048 Protein S100-A13 S100A13 0.0009
2226 Protein S100-A12 S100A12 0.0009
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0009
1970 Protein kinase C alpha type PRKCA 0.0009
6042 Prostaglandin reductase 2 PTGR2 0.0009
6171 Solute carrier family 28 member 3 SLC28A3 0.0009
22 30S ribosomal protein S4 rpsD 0.0008
6714 30S ribosomal protein S4 rpsD 0.0008
1792 Tissue-type plasminogen activator PLAT 0.0008
3616 Fatty acid-binding protein, epidermal FABP5 0.0008
5433 UPF0230 protein TM_1468 TM_1468 0.0008
5430 Hepatocyte nuclear factor 4-gamma HNF4G 0.0008
5431 Lipid binding protein Not Available 0.0008
1867 Major prion protein PRNP 0.0008
2232 Interleukin-5 IL5 0.0008
1593 Mucin-2 MUC2 0.0008
4031 Glutathione S-transferase A1 GSTA1 0.0008
500 Monocarboxylate transporter 4 SLC16A3 0.0008
1649 Small inducible cytokine A2 CCL2 0.0008
2530 Protein kinase C theta type PRKCQ 0.0008
1025 Aquaporin-1 AQP1 0.0008
4226 Uridine phosphorylase 2 UPP2 0.0007
130 Prostacyclin synthase PTGIS 0.0007
6103 Arylamine N-acetyltransferase 1 NAT1 0.0007
822 Aldose reductase AKR1B1 0.0007
6207 30S ribosomal protein S14 rpsN 0.0007
6209 30S ribosomal protein S19 rpsS 0.0007
6712 30S ribosomal protein S19 rpsS 0.0007
6726 30S ribosomal protein S19 rpsS 0.0007
283 SEC14-like protein 2 SEC14L2 0.0007
6134 Sodium channel subunit beta-3 SCN3B 0.0007
6133 Sodium channel subunit beta-2 SCN2B 0.0007
6135 Sodium channel subunit beta-4 SCN4B 0.0007
6132 Sodium channel subunit beta-1 SCN1B 0.0007
6129 Carbonic anhydrase-related protein 11 CA11 0.0007
6127 Carbonic anhydrase-related protein CA8 0.0007
6128 Carbonic anhydrase-related protein 10 CA10 0.0007
645 Penicillin-binding protein 1A mrcA 0.0007
5805 Penicillin-binding protein 1A ponA 0.0007
6185 Penicillin-binding protein 1A mrcA 0.0007
6799 Penicillin-binding protein 1A pbpA 0.0007
3587 Gastrotropin FABP6 0.0007
2511 MAP kinase-activated protein kinase 2 MAPKAPK2 0.0007
226 Gonadotropin-releasing hormone receptor GNRHR 0.0007
1313 Lactoylglutathione lyase GLO1 0.0007
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.0007
6837 Serine/threonine-protein kinase 17B STK17B 0.0007
4225 Uridine phosphorylase 1 UPP1 0.0007
76 Nitric-oxide synthase, brain NOS1 0.0007
125 DNA polymerase beta POLB 0.0007
2211 Fatty acid-binding protein, heart FABP3 0.0007
1123 Eosinophil cationic protein RNASE3 0.0007
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0006
413 Amidophosphoribosyltransferase PPAT 0.0006
2515 Amidophosphoribosyltransferase purF 0.0006
3714 Amidophosphoribosyltransferase purF 0.0006
6677 Myelin P2 protein PMP2 0.0006
342 P protein [Includes: DNA-directed DNA polymerase P 0.0006
612 P protein [Includes: DNA-directed DNA polymerase P 0.0006
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0006
6130 Carbonic anhydrase 13 CA13 0.0006
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0006
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.0006
1721 Glycogen synthase kinase-3 beta GSK3B 0.0005
3639 Thymidine phosphorylase deoA 0.0005
3936 Thymidine phosphorylase TYMP 0.0005
2183 Fatty acid-binding protein, adipocyte FABP4 0.0005
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0005
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.0005
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.0005
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.0005
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0005
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0004
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0004
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.0004
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0004
5818 Folate receptor alpha FOLR1 0.0004
340 Apoptotic protease-activating factor 1 APAF1 0.0004
2391 Ferrochelatase hemH 0.0004
6502 Ferrochelatase DKFZp686P18130 0.0004
1591 Ferrochelatase, mitochondrial FECH 0.0004
825 Arsenical pump-driving ATPase ASNA1 0.0003
3435 Arsenical pump-driving ATPase arsA 0.0003
486 Serine/threonine-protein kinase ALS2CR7 CDK15 0.0003
2105 ATP-binding cassette sub-family G member 1 ABCG1 0.0003
377 Beta-adrenergic receptor kinase 1 ADRBK1 0.0003
510 Serine/threonine-protein kinase receptor R3 ACVRL1 0.0003
733 Activin receptor type 1B ACVR1B 0.0003
225 NEDD8-activating enzyme E1 regulatory subunit NAE1 0.0003
745 Anti-Muellerian hormone type-2 receptor AMHR2 0.0003
483 A-Raf proto-oncogene serine/threonine-protein kinase ARAF 0.0003
21 Beta-adrenergic receptor kinase 2 ADRBK2 0.0003
154 AFG3-like protein 2 AFG3L2 0.0003
395 ALK tyrosine kinase receptor Not Available 0.0003
6496 Cytochrome c oxidase subunit 8A, mitochondrial COX8A 0.0003
6493 Cytochrome c oxidase subunit 6C COX6C 0.0003
6495 Cytochrome c oxidase subunit 7C, mitochondrial COX7C 0.0003
6499 Cytochrome c oxidase polypeptide 7A1, mitochondrial COX7A1 0.0003
6494 Cytochrome c oxidase subunit 7B, mitochondrial COX7B 0.0003
6491 Cytochrome c oxidase subunit 5A, mitochondrial COX5A 0.0003
6498 Cytochrome c oxidase subunit 6B1 COX6B1 0.0003
6497 Cytochrome c oxidase subunit 6A2, mitochondrial COX6A2 0.0003
6489 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial COX4I1 0.0003
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.0003
6559 Cytochrome c oxidase subunit 2 ctaC 0.0003
6669 Cytochrome c oxidase subunit 2 ctaC 0.0003
6490 Cytochrome c oxidase subunit 3 MT-CO3 0.0003
371 Cytochrome c oxidase subunit 1 MT-CO1 0.0003
6558 Cytochrome c oxidase subunit 1 ctaD 0.0003
292 Activin receptor type-1 ACVR1 0.0003
849 Activated CDC42 kinase 1 TNK2 0.0003
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0003
2540 Choloylglycine hydrolase cbh 0.0003
704 Long-chain-fatty-acid--CoA ligase 1 ACSL1 0.0003
821 Acetyl-coenzyme A synthetase 2-like, mitochondrial ACSS1 0.0003
386 Acetyl-coenzyme A synthetase, cytoplasmic ACSS2 0.0003
297 Adenylate cyclase type 1 ADCY1 0.0003
289 Cytosolic purine 5'-nucleotidase NT5C2 0.0003
6501 Fatty acid-binding protein, liver FABP1 0.0003
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0003
740 Argininosuccinate synthase ASS1 0.0002
865 Argininosuccinate synthase ASS1 0.0002
2680 Argininosuccinate synthase argG 0.0002
3194 Argininosuccinate synthase argG 0.0002
661 ADP/ATP translocase 1 SLC25A4 0.0002
6021 Adenosine kinase ADK 0.0002
242 Asparagine synthetase [glutamine-hydrolyzing] ASNS 0.0002
6500 Phospholipase A2 PLA2G1B 0.0002
4936 Cytochrome c2 iso-2 Not Available 0.0001
4916 Cyanoglobin glbN 0.0001
4994 Hemoglobin-like protein HbO glbO 0.0001
4915 Cytochrome c-550 psbV 0.0001
4959 Cytochrome c-550 psbV 0.0001
5216 Cytochrome c-550 psbV 0.0001
4925 Cytochrome c-type protein SHP shp 0.0001
4904 Cytochrome c family protein GSU1996 0.0001
4943 Cytochrome c6 petJ 0.0001
4954 Soluble cytochrome b558 Not Available 0.0001
4934 Cytochrome c-551 nirM 0.0001
5218 Cytochrome c-551 nirM 0.0001
4905 Cytochrome c2 Not Available 0.0001
4939 Cytochrome c2 cycA 0.0001
4964 Cytochrome c2 cycA 0.0001
4979 Cytochrome c2 cycA 0.0001
6673 Cytochrome c2 cycA 0.0001
4910 Cytoglobin CYGB 0.0001
4984 Neuroglobin NGB 0.0001
4981 Iron-starvation protein PigA pigA 0.0001
4909 CooA protein cooA 0.0001
4998 Hemoglobin-like protein yjbI yjbI 0.0001
4935 Cytochrome c-554 cycA1 0.0001
4947 Bacterial hemoglobin vhb 0.0001
4975 Cytochrome c-556 RPA3973 0.0001
4942 Diheme cytochrome c napB napB 0.0001
4931 Cytochrome P450 167A1 CYP167A1 0.0001
5000 HemO hemO 0.0001
4972 P450cin cinA 0.0001
4960 Putative cytochrome P450-family protein SCO7417 0.0001
4971 Nonaheme cytochrome c hmcA 0.0001
4989 Cytochrome c551 peroxidase ccp 0.0001
5222 Cytochrome c551 peroxidase ccpA 0.0001
4961 Hemophore HasA hasA 0.0001
4976 Apocytochrome f petA 0.0001
6407 Apocytochrome f petA 0.0001
4907 Cytochrome c-L moxG 0.0001
6865 Cytochrome c-L moxG 0.0001
4993 Hydroxylamine oxidoreductase hao1 0.0001
4764 Cytochrome P450 165C4 CYP165C4 0.0001
4926 Heme-based aerotactic transducer hemAT hemAT 0.0001
644 Heme oxygenase 2 HMOX2 0.0001
4982 Heme oxygenase 2 pbsA2 0.0001
4952 Catalase/peroxidase katA 0.0001
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0001
4937 Cytochrome oxidase subunit II rcoxA 0.0001
4903 Methyl-accepting chemotaxis protein Tar4 0.0001
4999 Cytochrome P450 165B3 CYP165B3 0.0001
3093 Catalase HPII katE 0.0001
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0001
4922 Cytochrome c, putative SO_4144 0.0001
4920 Peroxidase/catalase katG 0.0001
4990 PpcA ppcA 0.0001
4948 Cytochrome c-553 Not Available 0.0001
4923 Cytochrome c3 DvMF_2499 0.0001
4945 Cytochrome c3 Not Available 0.0001
4949 Cytochrome c3 DVU_3171 0.0001
4968 Cytochrome c3 cytc3 0.0001
4997 Cytochrome c3 SO_2727 0.0001
5219 Cytochrome c3 cyd 0.0001
2119 Cytochrome b5 CYB5A 0.0001
4902 Nine-heme cytochrome c Ddes_2038 0.0001
3189 High-molecular-weight cytochrome c hmcA 0.0001
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0001
3375 Acidic cytochrome c3 Not Available 0.0001
4988 Sulfite oxidase, mitochondrial SUOX 0.0001
2915 Sensor protein fixL fixL 0.0001
4944 Sensor protein fixL fixL 0.0001
4813 Heme oxygenase hmuO 0.0001
5769 Heme oxygenase Not Available 0.0001
3570 Cytochrome P450 152A1 cypC 0.0001
4385 Cytochrome c' Not Available 0.0001
4967 Cytochrome c' cycA 0.0001
5038 Cytochrome c' Not Available 0.0001
5223 Cytochrome c' cycP 0.0001
4037 Hypothetical protein GPX1 0.0001
4297 Hypothetical protein SP_1951 0.0001
4521 Hypothetical protein BC_2969 0.0001
4540 Hypothetical protein TM_1070 0.0001
4555 Hypothetical protein MT1739 0.0001
4569 Hypothetical protein mshD 0.0001
4578 Hypothetical protein PA3270 0.0001
4747 Hypothetical protein PA3967 0.0001
5177 Hypothetical protein TM_0096 0.0001
5194 Hypothetical protein PA1204 0.0001
5240 Hypothetical protein Rv2991 0.0001
5370 Hypothetical protein TM_1158 0.0001
5710 Hypothetical protein Tb927.5.1360 0.0001
4289 Cytochrome P450 TT_P0059 0.0001
6262 Cytochrome P450 staP 0.0001
4992 Cytochrome c peroxidase Not Available 0.0001
3670 Soluble cytochrome b562 precursor cybC 0.0001
3411 Cytochrome P450 121 cyp121 0.0001
3291 Cytochrome c-552 cycA 0.0001
4927 Cytochrome c-552 nrfA 0.0001
4938 Cytochrome c-552 cycA 0.0001
4953 Cytochrome c-552 nrfA 0.0001
5217 Cytochrome c-552 cycM 0.0001
2617 Nitric oxide synthase oxygenase nos 0.0001
2701 Nitric oxide synthase oxygenase nos 0.0001
3102 Flavohemoprotein hmp 0.0001
4969 Flavohemoprotein hmp 0.0001
4386 Hemoglobin-like protein HbN glbN 0.0001
3127 Nitrite reductase nirS 0.0001
3284 Nitrite reductase nirS 0.0001
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0001
2972 6-deoxyerythronolide B hydroxylase eryF 0.0001
4608 Putative cytochrome P450 SCO1207 0.0001
4963 Putative cytochrome P450 SCO2884 0.0001
6254 Putative cytochrome P450 SCO6998 0.0001
693 Hemoglobin subunit beta HBB 0
6268 Hydroxyacid oxidase 1 HAO1 0
810 Heme oxygenase 1 HMOX1 0
3391 Heme oxygenase 1 pbsA1 0
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