DT-Web

DB06697 - Artemether


Identification
Name Artemether
Accession Number DB06697
Type small molecule
Description Artemether is an antimalarial agent used to treat acute uncomplicated malaria. It is administered in combination with lumefantrine for improved efficacy. This combination therapy exerts its effects against the erythrocytic stages of Plasmodium spp. and may be used to treat infections caused by P. falciparum and unidentified Plasmodium species, including infections acquired in chloroquine-resistant areas.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 298.3746
Groups approved
Monoisotopic Weight 298.178023942
Pharmacology
Indication Artemether and lumefantrine combination therapy is indicated for the treatment of acute uncomplicated malaria caused by Plasmodium falciparum, including malaria acquired in chloroquine-resistant areas. May also be used to treat uncomplicated malaria when the Plasmodium species has not been identified. Indicated for use in adults and children greater than 5 kg.
Mechanism of action Involves an interaction with ferriprotoporphyrin IX ("heme"), or ferrous ions, in the acidic parasite food vacuole, which results in the generation of cytotoxic radical species. The generally accepted mechanism of action of peroxide antimalarials involves interaction of the peroxide-containing drug with heme, a hemoglobin degradation byproduct, derived from proteolysis of hemoglobin. This interaction is believed to result in the formation of a range of potentially toxic oxygen and carbon-centered radicals.
Absorption Food increases absorption.
Protein binding Artemether and lumefantrine are both highly bound to human serum proteins in vitro (95.4% and 99.7%, respectively). Dihydroartemisinin is also bound to human serum proteins (47% to 76%).
Biotransformation Rapidly metablized to its active metabolite, dihydroartemisinin.
Route of elimination Not Available
Toxicity Animal studies on acute toxicity show that the LD50 of Artemether in mice is a single i.g. administration of 895mg/kg and a single i.m. injection of 296mg/kg dose; in rats, the LD50 is a single i.m. injection of 597mg/kg dose.
Affected organisms
  • Plasmodium
Interactions
Drug Interactions
Drug Mechanism of interaction
Amiodarone Additive QTc-prolongation may occur. Concomitant therapy should be avoided.
Amitriptyline Additive QTc-prolongation may occur. Concomitant therapy should be avoided.
Amoxapine Additive QTc-prolongation may occur. Concomitant therapy should be avoided.
Apomorphine Additive QTc-prolongation may occur. Concomitant therapy should be avoided.
Arsenic trioxide Additive QTc-prolongation may occur. Concomitant therapy should be avoided.
Asenapine Additive QTc-prolongation may occur. Concomitant therapy should be avoided.
Azithromycin Additive QTc-prolongation may occur. Concomitant therapy should be avoided.
Bepridil Additive QTc-prolongation may occur. Concomitant therapy should be avoided.
Chloroquine Chloroquine may increase the adverse effects of artemether. Combination therapy is contraindicated unless there are no other treatment options.
Chlorpromazine Additive QTc-prolongation may occur. Concomitant therapy should be avoided.
Cisapride Additive QTc-prolongation may occur. Concomitant therapy should be avoided.
Citalopram Additive QTc-prolongation may occur. Concomitant therapy should be avoided.
Clarithromycin Additive QTc-prolongation may occur. Concomitant therapy should be avoided.
Clomipramine Additive QTc-prolongation may occur. Concomitant therapy should be avoided.
Conivaptan Conivaptan, a strong CYP3A inhibitor, may increase the toxicity of artemether by inhibiting its metabolism. Consider alternate therapy or allow at least 7 days to elapse between conivaptan and artemether therapy.
Dasatinib Additive QTc-prolongation may occur. Concomitant therapy should be avoided.
Degarelix Additive QTc-prolongation may occur. Concomitant therapy should be avoided.
Desipramine Additive QTc-prolongation may occur. Concomitant therapy should be avoided.
Desogestrel Artemether may decrease the effectiveness of desogestrel by increasing its metabolism via CYP3A4. Consider an alternate non-hormonal means of contraception during artemether therapy.
Disopyramide Additive QTc-prolongation may occur. Concomitant therapy should be avoided.
Dofetilide Additive QTc-prolongation may occur. Concomitant therapy should be avoided.
Dolasetron Additive QTc-prolongation may occur. Concomitant therapy should be avoided.
Domperidone Additive QTc-prolongation may occur. Concomitant therapy should be avoided.
Doxepin Additive QTc-prolongation may occur. Concomitant therapy should be avoided.
Dronedarone Additive QTc-prolongation may occur. Concomitant therapy is contraindicated.
Droperidol Additive QTc-prolongation may occur. Concomitant therapy should be avoided.
Drospirenone Artemether may decrease the effectiveness of drospirinone by increasing its metabolism via CYP3A4. Consider an alternate non-hormonal means of contraception during artemether therapy.
Erythromycin Additive QTc-prolongation may occur. Concomitant therapy should be avoided.
Escitalopram Additive QTc-prolongation may occur. Concomitant therapy should be avoided.
Ethinyl Estradiol Artemether may decrease the effectiveness of ethinyl estradiol by increasing its metabolism via CYP3A4. Consider an alternate non-hormonal means of contraception during artemether therapy.
Ethynodiol Diacetate Artemether may decrease the effectiveness of ethynodiol diacetate by increasing its metabolism via CYP3A4. Consider an alternate non-hormonal means of contraception during artemether therapy.
Etonogestrel Artemether may decrease the effectiveness of etonogestrel by increasing its metabolism via CYP3A4. Consider an alternate non-hormonal means of contraception during artemether therapy.
Etravirine Artemether, when administered concomitantly with etravirine, may experience a decrease in serum concentrations of active metabolites such as dihydroartemisinin; however, artemether may increase in serum concentration. Etravirine, when used with artemether, may increase in serum concentration. Caution and monitoring of therapeuric efficacy of artemether is recommended.
Flecainide Additive QTc-prolongation may occur. Concomitant therapy should be avoided.
Fluconazole Additive QTc-prolongation may occur. Concomitant therapy should be avoided.
Fluoxetine Additive QTc-prolongation may occur. Concomitant therapy should be avoided.
Flupenthixol Additive QTc-prolongation may occur. Concomitant therapy should be avoided.
Foscarnet Additive QTc-prolongation may occur. Concomitant therapy should be avoided.
Gadobutrol Additive QTc-prolongation may occur. Concomitant therapy should be avoided.
Gadofosveset trisodium Additive QTc-prolongation may occur. Concomitant therapy should be avoided.
Halofantrine Halofantrine may increase the adverse effects of artemether. Combination therapy is contraindicated unless there are no other treatment options.
Haloperidol Additive QTc-prolongation may occur. Concomitant therapy should be avoided.
Hydroxychloroquine Hydroxychloroquine may increase the adverse effects of artemether. Combination therapy is contraindicated unless there are no other treatment options.
Ibutilide Additive QTc-prolongation may occur. Concomitant therapy should be avoided.
Iloperidone Additive QTc-prolongation may occur. Concomitant therapy should be avoided.
Imipramine Additive QTc-prolongation may occur. Concomitant therapy should be avoided.
Indapamide Additive QTc-prolongation may occur. Concomitant therapy should be avoided.
Isradipine Additive QTc-prolongation may occur. Concomitant therapy should be avoided.
Ketoconazole Concurrent oral administration of ketoconazole, a potent CYP3A4 inhibitor, with a single dose of Coartem Tablets resulted in a moderate increase in exposure to artemether, DHA, and lumefantrine in a study of 15 healthy subjects.
Lapatinib Additive QTc-prolongation may occur. Concomitant therapy should be avoided.
Levofloxacin Additive QTc-prolongation may occur. Concomitant therapy should be avoided.
Levonorgestrel Artemether may decrease the effectiveness of levonorgestrel by increasing its metabolism via CYP3A4. Consider an alternate non-hormonal means of contraception during artemether therapy.
Loxapine Additive QTc-prolongation may occur. Concomitant therapy should be avoided.
Maprotiline Additive QTc-prolongation may occur. Concomitant therapy should be avoided.
Medroxyprogesterone Artemether may decrease the effectiveness of medroxyprogesterone by increasing its metabolism via CYP3A4. Consider an alternate non-hormonal means of contraception during artemether therapy.
Mefloquine Mefloquine may increase the adverse effects of artemether. Combination therapy is contraindicated unless there are no other treatment options.
Mesoridazine Additive QTc-prolongation may occur. Concomitant therapy should be avoided.
Mestranol Artemether may decrease the effectiveness of mestranol by increasing its metabolism via CYP3A4. Consider an alternate non-hormonal means of contraception during artemether therapy.
Methadone Additive QTc-prolongation may occur. Concomitant therapy should be avoided.
Methotrimeprazine Additive QTc-prolongation may occur. Concomitant therapy should be avoided.
Moxifloxacin Additive QTc-prolongation may occur. Concomitant therapy should be avoided.
Nilotinib Additive QTc-prolongation may occur. Concomitant therapy should be avoided.
Norelgestromin Artemether may decrease the effectiveness of norelgestromin by increasing its metabolism via CYP3A4. Consider an alternate non-hormonal means of contraception during artemether therapy.
Norethindrone Artemether may decrease the effectiveness of norethindrone by increasing its metabolism via CYP3A4. Consider an alternate non-hormonal means of contraception during artemether therapy.
Norfloxacin Additive QTc-prolongation may occur. Concomitant therapy should be avoided.
Norgestimate Artemether may decrease the effectiveness of norgestimate by increasing its metabolism via CYP3A4. Consider an alternate non-hormonal means of contraception during artemether therapy.
Nortriptyline Additive QTc-prolongation may occur. Concomitant therapy should be avoided.
Octreotide Additive QTc-prolongation may occur. Concomitant therapy should be avoided.
Pazopanib Additive QTc-prolongation may occur. Concomitant therapy should be avoided.
Pentamidine Additive QTc-prolongation may occur. Concomitant therapy should be avoided.
Perflutren Additive QTc-prolongation may occur. Concomitant therapy should be avoided.
Pimozide Additive QTc-prolongation may occur. Concomitant therapy is contraindicated.
Primaquine Primaquine may increase the adverse effects of artemether. Combination therapy is contraindicated unless there are no other treatment options.
Probucol Additive QTc-prolongation may occur. Concomitant therapy should be avoided.
Procainamide Additive QTc-prolongation may occur. Concomitant therapy should be avoided.
Proguanil Proguanil may increase the adverse effects of artemether. Combination therapy is contraindicated unless there are no other treatment options.
Propafenone Additive QTc-prolongation may occur. Concomitant therapy should be avoided.
Protriptyline Additive QTc-prolongation may occur. Concomitant therapy should be avoided.
Pyrimethamine Pyrimethamine may increase the adverse effects of artemether. Combination therapy is contraindicated unless there are no other treatment options.
Quetiapine Additive QTc-prolongation may occur. Concomitant therapy should be avoided.
Quinidine Additive QTc-prolongation may occur. Concomitant therapy should be avoided.
Quinine Quinine may increase the adverse effects of artemether. Combination therapy is contraindicated unless there are no other treatment options.
Ranolazine Additive QTc-prolongation may occur. Concomitant therapy should be avoided.
Rifampin Oral administration of rifampin, a strong CYP3A4 inducer, with Coartem Tablets resulted in significant decreases in exposure to artemether, dihydroartemisinin (DHA, metabolite of artemether) and lumefantrine by 89%, 85% and 68%, respectively, when compared to exposure values after Coartem Tablets alone. Concomitant use of strong inducers of CYP3A4 such as rifampin, carbamazepine, phenytoin and St. John's wort is contraindicated with Coartem Tablets.
Risperidone Additive QTc-prolongation may occur. Concomitant therapy should be avoided.
Romidepsin Additive QTc-prolongation may occur. Concomitant therapy should be avoided.
Saquinavir Additive QTc-prolongation may occur. Concomitant therapy should be avoided.
Sotalol Additive QTc-prolongation may occur. Concomitant therapy should be avoided.
Sparfloxacin Additive QTc-prolongation may occur. Concomitant therapy should be avoided.
Sunitinib Additive QTc-prolongation may occur. Concomitant therapy should be avoided.
Tacrolimus Additive QTc-prolongation may occur. Concomitant therapy should be avoided.
Telavancin Additive QTc-prolongation may occur. Concomitant therapy should be avoided.
Telithromycin Additive QTc-prolongation may occur. Concomitant therapy should be avoided.
Tetrabenazine Additive QTc-prolongation may occur. Concomitant therapy should be avoided.
Thioridazine Additive QTc-prolongation may occur. Concomitant therapy is contraindicated.
Thiothixene Additive QTc-prolongation may occur. Concomitant therapy should be avoided.
Toremifene Additive QTc-prolongation may occur. Concomitant therapy should be avoided.
Trimipramine Additive QTc-prolongation may occur. Concomitant therapy should be avoided.
Voriconazole Additive QTc-prolongation may occur. Concomitant therapy should be avoided.
Vorinostat Additive QTc-prolongation may occur. Concomitant therapy should be avoided.
Ziprasidone Additive QTc-prolongation may occur. Concomitant therapy should be avoided.
Food Interactions
  • Grapefruit juice may increase the toxicity of artemether and lumefantrine by inhibiting their metabolism.
  • Take with food as food increases the absorption of artemether and lumefantrine.

Enzymes


Cytochrome P450 3A4
Name Cytochrome P450 3A4
Gene Name CYP3A4
Actions substrate,inducer
References
  • Novartis. Coartem (artemether/lumefantrine) tablets prescribing information. East Hanover, NJ; 2010 Feb. -
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.6261
Cytochrome P450 3A5
Name Cytochrome P450 3A5
Gene Name CYP3A5
Actions substrate
References
  • Novartis. Coartem (artemether/lumefantrine) tablets prescribing information. East Hanover, NJ; 2010 Feb. -
DTHybrid score 0.3112
Cytochrome P450 2B6
Name Cytochrome P450 2B6
Gene Name CYP2B6
Actions substrate,inducer
References
  • Novartis. Coartem (artemether/lumefantrine) tablets prescribing information. East Hanover, NJ; 2010 Feb. -
  • Elsherbiny DA, Asimus SA, Karlsson MO, Ashton M, Simonsson US: A model based assessment of the CYP2B6 and CYP2C19 inductive properties by artemisinin antimalarials: implications for combination regimens. J Pharmacokinet Pharmacodyn. 2008 Apr;35(2):203-17. Epub 2008 Mar 19. - Pubmed
DTHybrid score 0.3063
Cytochrome P450 2C9
Name Cytochrome P450 2C9
Gene Name CYP2C9
Actions substrate
References
  • Novartis. Coartem (artemether/lumefantrine) tablets prescribing information. East Hanover, NJ; 2010 Feb. -
DTHybrid score 0.445
Cytochrome P450 2C19
Name Cytochrome P450 2C19
Gene Name CYP2C19
Actions substrate,inducer
References
  • Novartis. Coartem (artemether/lumefantrine) tablets prescribing information. East Hanover, NJ; 2010 Feb. -
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
  • Elsherbiny DA, Asimus SA, Karlsson MO, Ashton M, Simonsson US: A model based assessment of the CYP2B6 and CYP2C19 inductive properties by artemisinin antimalarials: implications for combination regimens. J Pharmacokinet Pharmacodyn. 2008 Apr;35(2):203-17. Epub 2008 Mar 19. - Pubmed
DTHybrid score 0.4045
Cytochrome P450 2D6
Name Cytochrome P450 2D6
Gene Name CYP2D6
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.4628

Predictions


Id Partner name Gene Name Score
4200 Cytochrome P450 1A2 CYP1A2 0.2464
4924 Cytochrome P450 2C8 CYP2C8 0.2391
1588 Multidrug resistance protein 1 ABCB1 0.2293
6107 Cytochrome P450 3A7 CYP3A7 0.1994
6013 Cytochrome P450 2E1 CYP2E1 0.1444
5718 Cytochrome P450 2A6 CYP2A6 0.1018
6024 Cytochrome P450 1A1 CYP1A1 0.0972
587 Serum albumin ALB 0.0843
20 Prostaglandin G/H synthase 1 PTGS1 0.0806
492 Histamine H1 receptor HRH1 0.0741
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0728
824 Sodium-dependent serotonin transporter SLC6A4 0.0652
6106 Cytochrome P450 2C18 CYP2C18 0.0617
540 Sodium-dependent noradrenaline transporter SLC6A2 0.053
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0529
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0527
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0513
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0472
502 5-hydroxytryptamine 2A receptor HTR2A 0.0466
862 Multidrug resistance-associated protein 1 ABCC1 0.0454
831 D(2) dopamine receptor DRD2 0.0447
556 Alpha-1A adrenergic receptor ADRA1A 0.0438
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0434
6145 Solute carrier family 22 member 1 SLC22A1 0.0409
3811 Cytochrome P450 19A1 CYP19A1 0.0403
103 Muscarinic acetylcholine receptor M1 CHRM1 0.04
713 Sodium-dependent dopamine transporter SLC6A3 0.0398
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0375
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0373
290 Prostaglandin G/H synthase 2 PTGS2 0.0371
847 Mu-type opioid receptor OPRM1 0.037
1729 Solute carrier family 22 member 6 SLC22A6 0.0358
6144 Solute carrier family 22 member 2 SLC22A2 0.0356
731 HIV-1 protease HIV-1 protease 0.0354
766 Beta-2 adrenergic receptor ADRB2 0.0345
1898 Cytochrome P450 1B1 CYP1B1 0.034
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0334
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0331
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0329
320 5-hydroxytryptamine 1A receptor HTR1A 0.0322
318 Alpha-2A adrenergic receptor ADRA2A 0.0317
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0307
590 5-hydroxytryptamine 2C receptor HTR2C 0.0304
776 Bile salt export pump ABCB11 0.0297
467 Delta-type opioid receptor OPRD1 0.0289
341 5-hydroxytryptamine 3 receptor HTR3A 0.0287
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0285
260 Cytochrome P450 51 ERG11 0.0284
761 Cytochrome P450 51 ERG11 0.0284
3163 Cytochrome P450 51 cyp51 0.0284
632 Alpha-1B adrenergic receptor ADRA1B 0.0282
696 Kappa-type opioid receptor OPRK1 0.027
118 Organic cation/carnitine transporter 2 SLC22A5 0.0268
136 Estrogen receptor ESR1 0.0267
193 Beta-1 adrenergic receptor ADRB1 0.0267
6031 Cytochrome P450 3A43 CYP3A43 0.0266
23 D(1A) dopamine receptor DRD1 0.0265
871 Glucocorticoid receptor NR3C1 0.0262
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0251
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0249
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0245
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0241
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.024
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.024
6142 Solute carrier family 22 member 8 SLC22A8 0.0237
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0234
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0233
468 Cytochrome P450 4A11 CYP4A11 0.023
3941 Amine oxidase [flavin-containing] A MAOA 0.0228
122 P2Y purinoceptor 12 P2RY12 0.0228
465 Calmodulin CALM1 0.0227
2164 Multidrug resistance-associated protein 4 ABCC4 0.0214
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0214
638 D(3) dopamine receptor DRD3 0.0213
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0212
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0207
6143 Solute carrier family 22 member 7 SLC22A7 0.0203
6182 Cytochrome P450 2J2 CYP2J2 0.0201
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0197
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0191
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0191
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0189
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0189
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0189
6147 Solute carrier family 22 member 3 SLC22A3 0.0188
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0187
3939 Amine oxidase [flavin-containing] B MAOB 0.0183
891 Dihydropteroate synthase folP 0.0182
5359 Dihydropteroate synthase folP 0.0182
7175 Dihydropteroate synthase sulI 0.0182
146 Androgen receptor AR 0.0181
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0177
817 DNA topoisomerase 2-alpha TOP2A 0.0175
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0173
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.017
833 Organic cation/carnitine transporter 1 SLC22A4 0.0168
789 Alpha-1D adrenergic receptor ADRA1D 0.0167
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0166
3923 Cholinesterase BCHE 0.0164
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0163
885 5-hydroxytryptamine 1B receptor HTR1B 0.0163
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0163
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0158
629 Alpha-2B adrenergic receptor ADRA2B 0.0158
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0157
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0154
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0153
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0152
6220 Aryl hydrocarbon receptor AHR 0.0146
432 D(4) dopamine receptor DRD4 0.0145
614 Progesterone receptor PGR 0.0143
378 Alpha-2C adrenergic receptor ADRA2C 0.0143
238 Peroxisome proliferator-activated receptor gamma PPARG 0.014
232 Corticosteroid-binding globulin SERPINA6 0.0139
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0136
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0136
504 Mast/stem cell growth factor receptor KIT 0.0135
844 Epidermal growth factor receptor EGFR 0.0133
725 5-hydroxytryptamine 1D receptor HTR1D 0.0131
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.013
124 Histamine H2 receptor HRH2 0.013
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0129
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0129
1656 CYP2B protein CYP2B 0.0129
811 Translocator protein TSPO 0.0128
6137 Multidrug resistance-associated protein 6 ABCC6 0.0128
4604 Liver carboxylesterase 1 CES1 0.0128
6148 Multidrug resistance-associated protein 7 ABCC10 0.0127
70 Type-1 angiotensin II receptor AGTR1 0.0126
4120 NADPH--cytochrome P450 reductase POR 0.0123
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0122
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0122
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0122
818 50S ribosomal protein L10 rplJ 0.012
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0119
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0119
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0119
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0119
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0119
705 Glutamate receptor 1 GRIA1 0.0118
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0118
174 Sigma 1-type opioid receptor SIGMAR1 0.0116
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0116
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0116
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0115
756 Sex hormone-binding globulin SHBG 0.0115
407 Vascular endothelial growth factor receptor 2 KDR 0.0114
6136 Multidrug resistance-associated protein 5 ABCC5 0.0114
716 5-hydroxytryptamine 7 receptor HTR7 0.0113
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0112
436 5-hydroxytryptamine 2B receptor HTR2B 0.0112
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0111
4148 Serine/threonine-protein kinase mTOR MTOR 0.011
161 Tubulin beta chain TUBB 0.011
312 Tubulin beta chain TUB2 0.011
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0109
1024 Solute carrier family 22 member 11 SLC22A11 0.0109
94 5-hydroxytryptamine 4 receptor HTR4 0.0105
777 Tumor necrosis factor TNF 0.0105
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0104
1010 Cytochrome P450 51A1 CYP51A1 0.0104
26 Vascular endothelial growth factor receptor 3 FLT4 0.0103
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0102
482 Glycine receptor subunit alpha-1 GLRA1 0.0101
427 Substance-P receptor TACR1 0.01
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0099
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0099
32 Vascular endothelial growth factor receptor 1 FLT1 0.0099
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0099
380 Cytochrome P450 17A1 CYP17A1 0.0098
474 Acetylcholinesterase ACHE 0.0098
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0097
131 Synaptic vesicular amine transporter SLC18A2 0.0097
737 Mineralocorticoid receptor NR3C2 0.0097
592 Carbonic anhydrase 4 CA4 0.0097
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0096
49 Endothelin B receptor EDNRB 0.0096
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0095
596 3-oxo-5-alpha-steroid 4-dehydrogenase 1 SRD5A1 0.0094
29 Tubulin beta-1 chain TUBB1 0.0094
295 Carbonic anhydrase 1 CA1 0.0094
163 D(1B) dopamine receptor DRD5 0.0094
228 Beta platelet-derived growth factor receptor PDGFRB 0.0093
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0093
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0093
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0093
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0092
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0092
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.009
578 Endothelin-1 receptor EDNRA 0.009
952 Dipeptidyl peptidase 4 DPP4 0.009
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0088
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0087
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0085
6014 Cytochrome P450 2A13 CYP2A13 0.0085
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0084
1757 Myeloperoxidase MPO 0.0083
642 3-oxo-5-alpha-steroid 4-dehydrogenase 2 SRD5A2 0.0083
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0083
6102 Arylamine N-acetyltransferase 2 NAT2 0.0083
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0082
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.008
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0079
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0079
869 Estrogen receptor beta ESR2 0.0079
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0079
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0078
442 Envelope glycoprotein gp41 0.0078
4859 Envelope glycoprotein env 0.0078
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0077
1256 5-hydroxytryptamine 6 receptor HTR6 0.0076
6141 Sodium/bile acid cotransporter SLC10A1 0.0075
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0075
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0074
6020 Aldehyde oxidase AOX1 0.0074
365 Dihydrofolate reductase DHFR 0.0073
2381 Dihydrofolate reductase DFR1 0.0073
2833 Dihydrofolate reductase Not Available 0.0073
2931 Dihydrofolate reductase folA 0.0073
3544 Dihydrofolate reductase folA 0.0073
3682 Dihydrofolate reductase folA 0.0073
6642 Dihydrofolate reductase folA 0.0073
6756 Dihydrofolate reductase dfrA 0.0073
4116 Dihydropteroate synthetase Not Available 0.0072
921 Glutamate receptor 2 GRIA2 0.0072
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0072
357 Carbonic anhydrase 2 CA2 0.0072
571 Melatonin receptor type 1A MTNR1A 0.007
362 Melatonin receptor type 1B MTNR1B 0.007
537 ATP synthase delta chain, mitochondrial ATP5D 0.007
528 5-hydroxytryptamine 1E receptor HTR1E 0.0069
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0069
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0069
2112 Toll-like receptor 9 TLR9 0.0069
2539 Tubulin alpha-1 chain TUBA4A 0.0068
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0067
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0067
4203 Histamine N-methyltransferase HNMT 0.0066
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0066
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0066
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0066
373 Transthyretin TTR 0.0065
823 Fibroblast growth factor receptor 2 FGFR2 0.0065
738 Monocarboxylate transporter 1 SLC16A1 0.0064
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0063
3947 Xanthine dehydrogenase/oxidase XDH 0.0063
856 Vitamin D3 receptor VDR 0.0063
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0063
133 Dihydropterate synthase sulI 0.0063
1618 High affinity nerve growth factor receptor NTRK1 0.0062
54 Prothrombin F2 0.0062
153 Dopamine beta-hydroxylase DBH 0.0061
183 Vascular endothelial growth factor A VEGFA 0.0061
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0061
3932 Glutathione S-transferase A2 GSTA2 0.006
275 Arachidonate 5-lipoxygenase ALOX5 0.006
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.006
6126 Carbonic anhydrase 7 CA7 0.006
208 DNA-directed RNA polymerase beta' chain rpoC 0.0059
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0059
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0059
3810 Catechol O-methyltransferase COMT 0.0059
68 Cannabinoid receptor 1 CNR1 0.0058
6085 Fatty acid-binding protein, intestinal FABP2 0.0058
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0058
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0058
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0058
723 Cytosolic phospholipase A2 PLA2G4A 0.0058
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0057
563 Thyroid peroxidase TPO 0.0056
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0056
165 FL cytokine receptor FLT3 0.0056
5300 Antigen peptide transporter 1 TAP1 0.0056
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0056
814 Ryanodine receptor 1 RYR1 0.0055
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0055
6506 Stathmin-4 STMN4 0.0055
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0054
581 Cytochrome P450 2R1 CYP2R1 0.0054
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0054
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0054
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0054
84 Nuclear receptor 0B1 NR0B1 0.0053
239 Coagulation factor X F10 0.0053
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0053
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0053
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0053
319 Opioid receptor, sigma 1 OPRS1 0.0052
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.005
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.005
768 FK506-binding protein 1A FKBP1A 0.005
4237 50S ribosomal protein L22 rplV 0.0049
1630 Integrin beta-2 ITGB2 0.0049
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0049
173 Toll-like receptor 7 TLR7 0.0049
6432 Transporter snf 0.0048
284 DNA-directed RNA polymerase beta chain rpoB 0.0048
5773 DNA-directed RNA polymerase beta chain rpoB 0.0048
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0048
780 Retinoic acid receptor RXR-gamma RXRG 0.0048
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0047
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.0047
1178 Adenosine A2a receptor ADORA2A 0.0047
4311 tRNA TRDMT1 0.0047
4325 tRNA trmD 0.0047
4328 tRNA trmD 0.0047
565 Extracellular calcium-sensing receptor CASR 0.0046
3086 Plasmepsin-2 Not Available 0.0046
6174 50S ribosomal protein L32 rpmF 0.0046
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0046
527 Prostacyclin receptor PTGIR 0.0045
4122 Histone deacetylase 2 HDAC2 0.0045
1196 Complement decay-accelerating factor CD55 0.0045
6138 Multidrug resistance protein 3 ABCB4 0.0044
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0044
130 Prostacyclin synthase PTGIS 0.0044
1483 Membrane copper amine oxidase AOC3 0.0043
88 Retinoic acid receptor RXR-beta RXRB 0.0043
518 Peroxidase/catalase T katG 0.0043
1275 Estrogen sulfotransferase SULT1E1 0.0043
469 Annexin A1 ANXA1 0.0043
477 DNA topoisomerase 4 subunit A parC 0.0042
886 DNA topoisomerase 4 subunit A parC 0.0042
6226 DNA topoisomerase 4 subunit A parC 0.0042
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0042
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0042
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0042
404 DNA gyrase subunit A gyrA 0.0042
6224 DNA gyrase subunit A gyrA 0.0042
1992 Vitamin D-binding protein GC 0.0042
1629 Transcription factor AP-1 JUN 0.0041
3997 Cytochrome P450 24A1, mitochondrial CYP24A1 0.0041
7 Nitric oxide synthase, inducible NOS2 0.0041
1192 Sulfotransferase 1A1 SULT1A1 0.004
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0039
1541 Metalloproteinase mmp20 0.0039
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.0039
2808 Chloramphenicol acetyltransferase 3 cat3 0.0039
1517 Beta-3 adrenergic receptor ADRB3 0.0039
16 Adenosine A1 receptor ADORA1 0.0039
1129 C-C chemokine receptor type 5 CCR5 0.0039
5787 Angiopoietin-1 receptor TEK 0.0038
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0038
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0038
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0038
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0038
6043 Putative G-protein coupled receptor 44 GPR44 0.0038
85 Growth hormone receptor GHR 0.0038
1852 Microtubule-associated protein 2 MAP2 0.0037
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0037
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0037
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0037
904 Glutathione S-transferase P GSTP1 0.0037
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0037
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0036
976 Platelet glycoprotein IX GP9 0.0036
1050 Bile salt sulfotransferase SULT2A1 0.0036
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0036
633 Penicillin-binding proteins 1A/1B pbpA 0.0036
3601 Dihydropteroate synthase 1 folP1 0.0036
3807 Dihydropteroate synthase 1 folP1 0.0036
3808 Dihydropteroate synthase 2 folP2 0.0036
2417 Chloramphenicol acetyltransferase cat 0.0036
3278 Chloramphenicol acetyltransferase cat 0.0036
634 Squalene monooxygenase SQLE 0.0035
7196 Squalene monooxygenase ERG1 0.0035
2810 Dr hemagglutinin structural subunit draA 0.0035
185 Vasopressin V1a receptor AVPR1A 0.0035
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0035
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0035
4773 Deoxycytidine kinase DCK 0.0035
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0035
6146 High affinity copper uptake protein 1 SLC31A1 0.0035
273 Apoptosis regulator Bcl-2 BCL2 0.0035
33 Cystine/glutamate transporter SLC7A11 0.0035
939 50S ribosomal protein L3 rplC 0.0035
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0035
322 Vasopressin V2 receptor AVPR2 0.0034
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0034
24 Thymidylate synthase TMP1 0.0034
359 Thymidylate synthase TYMS 0.0034
2626 Thymidylate synthase thyA 0.0034
2729 Thymidylate synthase thyA 0.0034
5352 Thymidylate synthase THYA 0.0034
4238 50S ribosomal protein L4 rplD 0.0033
5578 50S ribosomal protein L4 rplD 0.0033
6173 50S ribosomal protein L4 rplD 0.0033
6219 50S ribosomal protein L4 rplD 0.0033
558 Solute carrier family 12 member 1 SLC12A1 0.0033
3809 Estrogen-related receptor gamma ESRRG 0.0033
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0033
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0033
5934 Cytochrome P450 26A1 CYP26A1 0.0033
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0032
459 Retinoic acid receptor RXR-alpha RXRA 0.0032
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0032
6105 3-oxo-5-beta-steroid 4-dehydrogenase AKR1D1 0.0032
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0032
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0032
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0032
164 Histamine H4 receptor HRH4 0.0032
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0032
1770 Phospholipase C PLCL1 0.0032
2841 Phospholipase C plc 0.0032
267 Plasminogen activator inhibitor 1 SERPINE1 0.0032
140 30S ribosomal protein S9 rpsI 0.0031
6719 30S ribosomal protein S9 rpsI 0.0031
6725 30S ribosomal protein S9 rpsI 0.0031
1636 Trace amine-associated receptor 1 TAAR1 0.0031
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0031
1262 Corticotropin-lipotropin POMC 0.0031
1227 Cytochrome b MT-CYB 0.0031
6386 Cytochrome b petB 0.0031
6937 Cytochrome b MT-CYB 0.0031
674 Dihydroorotate dehydrogenase homolog, mitochondrial PFF0160c 0.0031
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0031
2981 Phospholipase A2, membrane associated PLA2G2A 0.0031
936 Ephrin type-A receptor 2 EPHA2 0.0031
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0031
2578 Tubulin beta-3 chain TUBB3 0.003
1353 DNA topoisomerase 1 TOP1 0.003
3552 DNA topoisomerase 1 topA 0.003
106 Cannabinoid receptor 2 CNR2 0.003
2285 Streptogramin A acetyltransferase vatD 0.003
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.003
5924 Microtubule-associated protein 4 MAP4 0.003
5923 Microtubule-associated protein tau MAPT 0.003
6044 Serum paraoxonase/lactonase 3 PON3 0.003
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.003
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0029
251 Alcohol dehydrogenase 1A ADH1A 0.0029
719 Retinoic acid receptor responder protein 1 RARRES1 0.0029
770 Retinoic acid-induced protein 3 GPRC5A 0.0029
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0029
6221 Steroid hormone receptor ERR1 ESRRA 0.0029
1039 Histone deacetylase 9 HDAC9 0.0028
3856 Fibroblast growth factor receptor 3 FGFR3 0.0028
3937 Fatty-acid amide hydrolase FAAH 0.0028
1200 AMBP protein AMBP 0.0028
3866 Serum amyloid A protein SAA1 0.0028
1932 Apolipoprotein E APOE 0.0028
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0027
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0027
572 Integrin alpha-L ITGAL 0.0027
820 Glycine receptor subunit alpha-2 GLRA2 0.0027
1144 Hepatocyte growth factor receptor MET 0.0027
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.0027
2449 Tubulin alpha-3 chain TUBA1A 0.0027
4173 Tyrosine-protein kinase JAK2 JAK2 0.0027
2159 Quinone oxidoreductase CRYZ 0.0027
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0027
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0027
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0027
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0027
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0027
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0027
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0027
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0027
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0027
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0027
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0027
4228 Keratin, type II cytoskeletal 7 KRT7 0.0027
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0027
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0027
1864 RET proto-oncogene RET 0.0026
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0026
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0026
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0026
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0026
444 Alcohol dehydrogenase 1B ADH1B 0.0026
4103 Proteasome subunit beta type 2 PSMB2 0.0026
3913 Glutamic acid decarboxylase GAD65 0.0026
4102 Proteasome subunit beta type 5 PSMB5 0.0026
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0026
4101 Proteasome subunit beta type 1 PSMB1 0.0026
569 Retinal dehydrogenase 2 ALDH1A2 0.0025
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0025
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0025
5798 Mitogen-activated protein kinase 11 MAPK11 0.0025
1648 Elastin ELN 0.0024
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0024
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0024
544 Potassium voltage-gated channel subfamily E member 1 KCNE1 0.0024
511 5-hydroxytryptamine 1F receptor HTR1F 0.0024
2300 Lysozyme E 0.0024
3633 Lysozyme R 0.0024
5597 Lysozyme 17 0.0024
6039 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A PDE11A 0.0024
611 Retinal dehydrogenase 1 ALDH1A1 0.0024
6048 Troponin C, skeletal muscle TNNC2 0.0024
233 Potassium channel subfamily K member 2 KCNK2 0.0024
5852 Type-2 angiotensin II receptor AGTR2 0.0024
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0024
65 Matrix metalloproteinase-9 Not Available 0.0023
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0023
1341 Histamine H3 receptor HRH3 0.0023
291 Nitric-oxide synthase, endothelial NOS3 0.0023
543 Penicillin-binding protein 1B mrcB 0.0023
6186 Penicillin-binding protein 1B ponB 0.0023
6822 Penicillin-binding protein 1b pbp1b 0.0023
6844 Penicillin-binding protein 1b pbp1b 0.0023
517 Alcohol dehydrogenase 1C ADH1C 0.0022
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0022
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0022
159 Penicillin-binding protein 2B penA 0.0022
6121 Penicillin-binding protein 2B penA 0.0022
3404 Exotoxin A eta 0.0022
6824 Tyrosine-protein kinase Lyn LYN 0.0022
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0022
2232 Interleukin-5 IL5 0.0022
3904 Alanine aminotransferase 2 GPT2 0.0021
735 Alanine aminotransferase 1 GPT 0.0021
298 Renin REN 0.0021
1593 Mucin-2 MUC2 0.0021
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0021
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0021
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0021
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0021
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0021
1268 Neuropeptide S receptor NPSR1 0.0021
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0021
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0021
63 Malate dehydrogenase mdh 0.0021
2329 Malate dehydrogenase mdh 0.0021
3445 Malate dehydrogenase mdh 0.0021
4420 Malate dehydrogenase mdh 0.0021
4438 Malate dehydrogenase mdh 0.0021
6149 Solute carrier family 22 member 10 SLC22A10 0.0021
4192 DNA topoisomerase 2-beta TOP2B 0.0021
3090 Chitosanase csn 0.002
4149 Nuclear factor NF-kappa-B p100 subunit NFKB2 0.002
3611 Cytidine deaminase cdd 0.002
3707 Cytidine deaminase cdd 0.002
4211 Cytidine deaminase CDA 0.002
1360 Sphingomyelin phosphodiesterase SMPD1 0.002
908 Glutathione S-transferase theta-1 GSTT1 0.002
2216 Fibroblast growth factor receptor 4 FGFR4 0.002
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.002
751 Potassium channel subfamily K member 6 KCNK6 0.002
6103 Arylamine N-acetyltransferase 1 NAT1 0.002
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.002
1525 Heparin-binding growth factor 2 FGF2 0.0019
2499 Tubulin beta-2C chain TUBB2C 0.0019
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0019
6073 Potassium channel subfamily K member 9 KCNK9 0.0019
6072 Potassium channel subfamily K member 3 KCNK3 0.0019
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0019
473 L-lactate dehydrogenase A chain LDHA 0.0019
162 Retinoic acid receptor gamma-1 RARG 0.0019
3639 Thymidine phosphorylase deoA 0.0019
3936 Thymidine phosphorylase TYMP 0.0019
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0019
4217 Telomerase reverse transcriptase TERT 0.0019
3426 Glutamine synthetase glnA 0.0019
3987 Glutamine synthetase GLUL 0.0019
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0019
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0019
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0018
893 [Citrate [pro-3S]-lyase] ligase citC 0.0018
845 Pyruvate dehydrogenase [cytochrome] poxB 0.0018
1253 Interferon gamma IFNG 0.0018
172 Potassium channel subfamily K member 1 KCNK1 0.0018
5998 Toll-like receptor 8 TLR8 0.0018
712 Tubulin alpha chain TUB1 0.0018
1968 ATP-sensitive inward rectifier potassium channel 12 KCNJ12 0.0018
327 Glutathione reductase gor 0.0018
5110 Glutathione reductase GR2 0.0018
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0018
683 Potassium transporter GK0582 0.0018
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.0018
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0018
1123 Eosinophil cationic protein RNASE3 0.0018
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0018
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.0017
613 Atrial natriuretic peptide receptor A NPR1 0.0017
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0017
2290 ADP-ribosyl cyclase 2 BST1 0.0017
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0017
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0017
1374 Natriuretic peptides B NPPB 0.0017
1827 Gap junction alpha-1 protein GJA1 0.0017
1908 Vascular cell adhesion protein 1 VCAM1 0.0017
896 Glutathione S-transferase Mu 1 GSTM1 0.0017
992 Protein tyrosine kinase 2 beta PTK2B 0.0017
3830 Calreticulin CALR 0.0017
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0017
78 Acetyl-CoA acetyltransferase, mitochondrial ACAT1 0.0016
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0016
144 Hemoglobin subunit alpha HBA1 0.0016
6034 Hydroxyindole O-methyltransferase ASMT 0.0016
6035 Nuclear receptor ROR-beta RORB 0.0016
6036 Eosinophil peroxidase EPX 0.0016
3233 Bile acid receptor NR1H4 0.0015
2853 14 kDa fatty acid-binding protein Not Available 0.0015
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0015
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0015
982 Cocaine- and amphetamine-regulated transcript protein CARTPT 0.0015
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0015
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0015
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0015
2207 Rhodopsin RHO 0.0014
2320 Thymidine kinase, cytosolic TK1 0.0014
268 Adenosine A2b receptor ADORA2B 0.0014
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0014
1063 Signal transducer and activator of transcription 5B STAT5B 0.0014
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.0014
765 Indoleamine 2,3-dioxygenase IDO1 0.0014
244 Angiotensin-converting enzyme ACE 0.0013
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0013
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0013
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0013
6218 Pannexin-1 PANX1 0.0013
6211 Tubulin epsilon chain TUBE1 0.0013
6212 Tubulin gamma-1 chain TUBG1 0.0013
6210 Tubulin delta chain TUBD1 0.0013
6168 Solute carrier family 22 member 16 SLC22A16 0.0013
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0013
6131 Carbonic anhydrase 14 CA14 0.0013
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0013
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0013
860 Nicotinamide N-methyltransferase NNMT 0.0013
1650 Heme carrier protein 1 SLC46A1 0.0013
699 Nicotinic acid receptor 1 GPR109A 0.0013
928 Nicotinic acid receptor 2 GPR109B 0.0013
583 Nicotinate-nucleotide pyrophosphorylase [carboxylating] QPRT 0.0013
2442 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
2459 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
6116 Gastric triacylglycerol lipase LIPF 0.0012
2021 Thrombomodulin THBD 0.0012
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0012
605 Fumarate reductase flavoprotein subunit frdA 0.0012
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0012
3673 Fumarate reductase flavoprotein subunit fccA 0.0012
4912 Fumarate reductase flavoprotein subunit ifcA 0.0012
6549 Fumarate reductase flavoprotein subunit frdA 0.0012
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0012
3823 Cytokine receptor common gamma chain IL2RG 0.0012
2107 Microtubule-associated protein 1A MAP1A 0.0012
338 DNA polymerase UL30 0.0012
379 DNA polymerase UL54 0.0012
697 DNA polymerase ORF28 0.0012
2482 DNA polymerase 43 0.0012
4104 DNA polymerase BALF5 0.0012
6122 Carbonic anhydrase 3 CA3 0.0012
1295 Fatty acid synthase FASN 0.0012
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0012
6163 Copper-transporting ATPase 2 ATP7B 0.0012
6165 Copper-transporting ATPase 1 ATP7A 0.0012
484 Tyrosine-protein kinase ABL2 ABL2 0.0011
754 Pancreatic triacylglycerol lipase PNLIP 0.0011
707 72 kDa type IV collagenase MMP2 0.0011
2183 Fatty acid-binding protein, adipocyte FABP4 0.0011
76 Nitric-oxide synthase, brain NOS1 0.0011
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0011
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0011
2178 Metabotropic glutamate receptor 5 GRM5 0.0011
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0011
724 Interleukin-2 receptor alpha chain IL2RA 0.0011
717 Interleukin-2 receptor subunit beta IL2RB 0.0011
6033 High affinity interleukin-8 receptor A CXCR1 0.001
1810 Protein S100-A1 S100A1 0.001
6097 Protein S100-A2 S100A2 0.001
4948 Cytochrome c-553 Not Available 0.001
4923 Cytochrome c3 DvMF_2499 0.001
4945 Cytochrome c3 Not Available 0.001
4949 Cytochrome c3 DVU_3171 0.001
4968 Cytochrome c3 cytc3 0.001
4997 Cytochrome c3 SO_2727 0.001
5219 Cytochrome c3 cyd 0.001
4902 Nine-heme cytochrome c Ddes_2038 0.001
3189 High-molecular-weight cytochrome c hmcA 0.001
493 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial CYP27B1 0.001
2450 Tyrosine-protein kinase ITK/TSK ITK 0.001
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.001
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.001
512 DNA-directed RNA polymerase alpha chain rpoA 0.001
5772 DNA-directed RNA polymerase alpha chain rpoA 0.001
4041 Microsomal glutathione S-transferase 2 MGST2 0.001
3957 Adenosine deaminase ADA 0.001
734 D1 dopamine receptor-interacting protein calcyon CALY 0.001
2268 Cholesterol oxidase choB 0.0009
2822 Cholesterol oxidase choA 0.0009
1064 DNA (cytosine-5)-methyltransferase 1 DNMT1 0.0009
828 Phenylalanine-4-hydroxylase PAH 0.0009
3109 Phenylalanine-4-hydroxylase phhA 0.0009
1048 Protein S100-A13 S100A13 0.0009
2226 Protein S100-A12 S100A12 0.0009
6042 Prostaglandin reductase 2 PTGR2 0.0009
2283 Steroid Delta-isomerase ksi 0.0009
2920 Steroid Delta-isomerase ksi 0.0009
4386 Hemoglobin-like protein HbN glbN 0.0009
2298 Cytochrome P450-cam camC 0.0009
390 Adenosine A3 receptor ADORA3 0.0009
2132 Protein S100-B S100B 0.0009
1792 Tissue-type plasminogen activator PLAT 0.0008
22 30S ribosomal protein S4 rpsD 0.0008
6714 30S ribosomal protein S4 rpsD 0.0008
2325 Sulfotransferase family cytosolic 2B member 1 SULT2B1 0.0008
489 Monocarboxylate transporter 2 SLC16A7 0.0008
1867 Major prion protein PRNP 0.0008
3221 Cytochrome c4 cc4 0.0008
4031 Glutathione S-transferase A1 GSTA1 0.0008
500 Monocarboxylate transporter 4 SLC16A3 0.0008
1649 Small inducible cytokine A2 CCL2 0.0008
1025 Aquaporin-1 AQP1 0.0008
2091 Endoplasmin HSP90B1 0.0008
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.0007
866 Large neutral amino acids transporter small subunit 2 SLC7A8 0.0007
461 Glycine receptor subunit alpha-3 GLRA3 0.0007
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0007
760 Fibroblast growth factor 1 FGF1 0.0007
6207 30S ribosomal protein S14 rpsN 0.0007
6209 30S ribosomal protein S19 rpsS 0.0007
6712 30S ribosomal protein S19 rpsS 0.0007
6726 30S ribosomal protein S19 rpsS 0.0007
6134 Sodium channel subunit beta-3 SCN3B 0.0007
6133 Sodium channel subunit beta-2 SCN2B 0.0007
6135 Sodium channel subunit beta-4 SCN4B 0.0007
6132 Sodium channel subunit beta-1 SCN1B 0.0007
6129 Carbonic anhydrase-related protein 11 CA11 0.0007
6127 Carbonic anhydrase-related protein CA8 0.0007
6128 Carbonic anhydrase-related protein 10 CA10 0.0007
645 Penicillin-binding protein 1A mrcA 0.0007
5805 Penicillin-binding protein 1A ponA 0.0007
6185 Penicillin-binding protein 1A mrcA 0.0007
6799 Penicillin-binding protein 1A pbpA 0.0007
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0007
1313 Lactoylglutathione lyase GLO1 0.0007
226 Gonadotropin-releasing hormone receptor GNRHR 0.0007
1507 Cytochrome c CYCS 0.0007
1830 5'-nucleotidase NT5E 0.0007
125 DNA polymerase beta POLB 0.0007
4226 Uridine phosphorylase 2 UPP2 0.0007
2599 Tyrosine-protein kinase HCK HCK 0.0007
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0006
6130 Carbonic anhydrase 13 CA13 0.0006
4225 Uridine phosphorylase 1 UPP1 0.0006
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0006
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0006
6167 Organic solute transporter subunit beta OSTB 0.0006
6166 Organic solute transporter subunit alpha OSTA 0.0006
4954 Soluble cytochrome b558 Not Available 0.0006
4925 Cytochrome c-type protein SHP shp 0.0006
4916 Cyanoglobin glbN 0.0006
4915 Cytochrome c-550 psbV 0.0006
4959 Cytochrome c-550 psbV 0.0006
5216 Cytochrome c-550 psbV 0.0006
4947 Bacterial hemoglobin vhb 0.0006
4934 Cytochrome c-551 nirM 0.0006
5218 Cytochrome c-551 nirM 0.0006
4994 Hemoglobin-like protein HbO glbO 0.0006
4984 Neuroglobin NGB 0.0006
4943 Cytochrome c6 petJ 0.0006
4975 Cytochrome c-556 RPA3973 0.0006
4905 Cytochrome c2 Not Available 0.0006
4939 Cytochrome c2 cycA 0.0006
4964 Cytochrome c2 cycA 0.0006
4979 Cytochrome c2 cycA 0.0006
6673 Cytochrome c2 cycA 0.0006
3116 Bacterioferritin bfr 0.0006
4906 Bacterioferritin bfr 0.0006
4965 Bacterioferritin bfr 0.0006
4910 Cytoglobin CYGB 0.0006
4936 Cytochrome c2 iso-2 Not Available 0.0006
4998 Hemoglobin-like protein yjbI yjbI 0.0006
4981 Iron-starvation protein PigA pigA 0.0006
5000 HemO hemO 0.0006
4907 Cytochrome c-L moxG 0.0006
6865 Cytochrome c-L moxG 0.0006
4909 CooA protein cooA 0.0006
4935 Cytochrome c-554 cycA1 0.0006
4942 Diheme cytochrome c napB napB 0.0006
644 Heme oxygenase 2 HMOX2 0.0006
4982 Heme oxygenase 2 pbsA2 0.0006
4971 Nonaheme cytochrome c hmcA 0.0006
4904 Cytochrome c family protein GSU1996 0.0006
4961 Hemophore HasA hasA 0.0006
4976 Apocytochrome f petA 0.0006
6407 Apocytochrome f petA 0.0006
4764 Cytochrome P450 165C4 CYP165C4 0.0006
4972 P450cin cinA 0.0006
4931 Cytochrome P450 167A1 CYP167A1 0.0006
4960 Putative cytochrome P450-family protein SCO7417 0.0006
4903 Methyl-accepting chemotaxis protein Tar4 0.0006
4926 Heme-based aerotactic transducer hemAT hemAT 0.0006
4999 Cytochrome P450 165B3 CYP165B3 0.0006
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0006
4989 Cytochrome c551 peroxidase ccp 0.0006
5222 Cytochrome c551 peroxidase ccpA 0.0006
4937 Cytochrome oxidase subunit II rcoxA 0.0006
4922 Cytochrome c, putative SO_4144 0.0006
4993 Hydroxylamine oxidoreductase hao1 0.0006
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0006
3093 Catalase HPII katE 0.0006
4952 Catalase/peroxidase katA 0.0006
413 Amidophosphoribosyltransferase PPAT 0.0006
2515 Amidophosphoribosyltransferase purF 0.0006
3714 Amidophosphoribosyltransferase purF 0.0006
1291 cAMP response element-binding protein CREB1 0.0006
1569 G1/S-specific cyclin-D1 CCND1 0.0006
5221 Cytochrome c3, 13 kDa Not Available 0.0006
3152 Cytochrome c'' cycA 0.0006
5220 Split-Soret cytochrome c Ddes_2150 0.0006
3700 Cytochrome c-552 precursor nrfA 0.0006
4210 Toll-like receptor 4 TLR4 0.0005
1760 Aminopeptidase N ANPEP 0.0005
6843 Aminopeptidase N pepN 0.0005
117 Sterol O-acyltransferase 1 SOAT1 0.0005
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0005
3007 Carbonic anhydrase 12 CA12 0.0005
4205 Carbonic anhydrase 9 CA9 0.0005
6151 Monocarboxylate transporter 10 SLC16A10 0.0005
3127 Nitrite reductase nirS 0.0005
3284 Nitrite reductase nirS 0.0005
1714 Mitogen-activated protein kinase 3 MAPK3 0.0005
2236 Casein kinase II subunit alpha CSNK2A1 0.0005
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0004
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0004
3917 Methylenetetrahydrofolate reductase MTHFR 0.0004
4920 Peroxidase/catalase katG 0.0004
2119 Cytochrome b5 CYB5A 0.0004
4990 PpcA ppcA 0.0004
3405 Quinohaemoprotein ethanol dehydrogenase type-1 qheDH 0.0004
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0004
3375 Acidic cytochrome c3 Not Available 0.0004
4988 Sulfite oxidase, mitochondrial SUOX 0.0004
2915 Sensor protein fixL fixL 0.0004
4944 Sensor protein fixL fixL 0.0004
4385 Cytochrome c' Not Available 0.0004
4967 Cytochrome c' cycA 0.0004
5038 Cytochrome c' Not Available 0.0004
5223 Cytochrome c' cycP 0.0004
3570 Cytochrome P450 152A1 cypC 0.0004
4813 Heme oxygenase hmuO 0.0004
5769 Heme oxygenase Not Available 0.0004
4037 Hypothetical protein GPX1 0.0004
4297 Hypothetical protein SP_1951 0.0004
4521 Hypothetical protein BC_2969 0.0004
4540 Hypothetical protein TM_1070 0.0004
4555 Hypothetical protein MT1739 0.0004
4569 Hypothetical protein mshD 0.0004
4578 Hypothetical protein PA3270 0.0004
4747 Hypothetical protein PA3967 0.0004
5177 Hypothetical protein TM_0096 0.0004
5194 Hypothetical protein PA1204 0.0004
5240 Hypothetical protein Rv2991 0.0004
5370 Hypothetical protein TM_1158 0.0004
5710 Hypothetical protein Tb927.5.1360 0.0004
4289 Cytochrome P450 TT_P0059 0.0004
6262 Cytochrome P450 staP 0.0004
4992 Cytochrome c peroxidase Not Available 0.0004
2230 Catalase CAT 0.0004
3249 Catalase katA 0.0004
3625 Catalase katA 0.0004
4539 Catalase katA 0.0004
4941 Catalase katB 0.0004
1176 Mitogen-activated protein kinase 1 MAPK1 0.0004
3411 Cytochrome P450 121 cyp121 0.0004
3670 Soluble cytochrome b562 precursor cybC 0.0004
3291 Cytochrome c-552 cycA 0.0004
4927 Cytochrome c-552 nrfA 0.0004
4938 Cytochrome c-552 cycA 0.0004
4953 Cytochrome c-552 nrfA 0.0004
5217 Cytochrome c-552 cycM 0.0004
2617 Nitric oxide synthase oxygenase nos 0.0004
2701 Nitric oxide synthase oxygenase nos 0.0004
3102 Flavohemoprotein hmp 0.0004
4969 Flavohemoprotein hmp 0.0004
594 Thyroxine-binding globulin SERPINA7 0.0004
758 Thyroid hormone receptor alpha THRA 0.0003
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0003
2972 6-deoxyerythronolide B hydroxylase eryF 0.0003
2240 Cell division protein kinase 2 CDK2 0.0003
199 Monocarboxylate transporter 8 SLC16A2 0.0003
4608 Putative cytochrome P450 SCO1207 0.0003
4963 Putative cytochrome P450 SCO2884 0.0003
6254 Putative cytochrome P450 SCO6998 0.0003
346 Thyroid hormone receptor beta-1 THRB 0.0003
358 Cystathionine beta-synthase CBS 0.0003
693 Hemoglobin subunit beta HBB 0.0003
6268 Hydroxyacid oxidase 1 HAO1 0.0003
810 Heme oxygenase 1 HMOX1 0.0003
3391 Heme oxygenase 1 pbsA1 0.0003
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0002
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