DT-Web: DB01254

Identification

Name

Dasatinib

Accession Number

DB01254

Type

small molecule

Description

Dasatinib is an oral dual BCR/ABL and Src family tyrosine kinase inhibitor approved for use in patients with chronic myelogenous leukemia (CML). The main targets of Dasatinib, are BCRABL, SRC, Ephrins and GFR.

Structure

MOL SDF PDB SMILES InChI

Categories ^(*)

Protein Kinase Inhibitors

Molecular Weight

488.006

Groups

approved

Monoisotopic Weight

487.155721508

Pharmacology

Indication

For the treatment of adults with chronic, accelerated, or myeloid or lymphoid blast phase chronic myeloid leukemia with resistance or intolerance to prior therapy. Also indicated for the treatment of adults with Philadelphia chromosome-positive acute lymphoblastic leukemia with resistance or intolerance to prior therapy.

Mechanism of action

Dasatinib, at nanomolar concentrations, inhibits the following kinases: BCR-ABL, SRC family (SRC, LCK, YES, FYN), c-KIT, EPHA2, and PDGFRβ. Based on modeling studies, dasatinib is predicted to bind to multiple conformations of the ABL kinase. In vitro, dasatinib was active in leukemic cell lines representing variants of imatinib mesylate sensitive and resistant disease. Dasatinib inhibited the growth of chronic myeloid leukemia (CML) and acute lymphoblastic leukemia (ALL) cell lines overexpressing BCR-ABL. Under the conditions of the assays, dasatinib was able to overcome imatinib resistance resulting from BCR-ABL kinase domain mutations, activation of alternate signaling pathways involving the SRC family kinases (LYN, HCK), and multi-drug resistance gene overexpression.

Absorption

Not Available

Protein binding

96%

Biotransformation

Dasatinib is extensively metabolized in humans, primarily by the cytochrome P450 enzyme 3A4

Route of elimination

Dasatinib is extensively metabolized in humans, primarily by the cytochrome P450 enzyme 3A4. Elimination is primarily via the feces.

Toxicity

Acute overdose in animals was associated with cardiotoxicity.

Affected organisms

Humans and other mammals

Interactions

Drug Interactions

Drug	Mechanism of interaction
Artemether	Additive QTc-prolongation may occur. Concomitant therapy should be avoided.
Etravirine	Dasatinib, when administered concomitantly with etravirine (a strong CYP3A4 inducer), may experience a decrease in serum concentration. It is recommended to avoid this combination if possible. If concurrent therapy cannot be avoided it is recommended to increase the dose of dasitinib and monitor for efficacy and toxicity.
Omeprazole	Omeprazole may decrease the serum level of dasatinib.
Pantoprazole	Pantoprazole may decrease the serum level of dasatinib.
Phenobarbital	Phenobarbital may decrease the serum level and efficacy of dasatinib.
Phenytoin	Phenytoin may decrease the serum level and efficacy of dasatinib.
Rabeprazole	Rabeprazole may decrease the serum level of dasatinib.
Ranitidine	Ranitidine may decrease the serum level of dasatinib.
Rifampin	Rifampin may decrease the serum level and efficacy of dasatinib.
Tacrolimus	Additive QTc-prolongation may occur increasing the risk of serious ventricular arrhythmias. Concomitant therapy should be used with caution.
Telithromycin	Telithromycin may reduce clearance of Dasatinib. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Dasatinib if Telithromycin is initiated, discontinued or dose changed.
Thiothixene	May cause additive QTc-prolonging effects. Increased risk of ventricular arrhythmias. Consider alternate therapy. Thorough risk:benefit assessment is required prior to co-administration.
Toremifene	Additive QTc-prolongation may occur, increasing the risk of serious ventricular arrhythmias. Consider alternate therapy. A thorough risk:benefit assessment is required prior to co-administration.
Trimipramine	Additive QTc-prolongation may occur, increasing the risk of serious ventricular arrhythmias. Concomitant therapy should be used with caution.
Voriconazole	Additive QTc prolongation may occur. Voriconazole, a strong CYP3A4 inhibitor, may also increase the serum concentration of dasatinib by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of dasatinib if voriconazole is initiated, discontinued or dose changed.
Vorinostat	Additive QTc prolongation may occur. Consider alternate therapy or monitor for QTc prolongation as this can lead to Torsade de Pointes (TdP).
Ziprasidone	Additive QTc-prolonging effects may increase the risk of severe arrhythmias. Concomitant therapy is contraindicated.
Zuclopenthixol	Additive QTc prolongation may occur. Consider alternate therapy or use caution and monitor for QTc prolongation as this can lead to Torsade de Pointes (TdP).

Food Interactions

Not Available

Proto-oncogene tyrosine-protein kinase ABL1
Name	Proto-oncogene tyrosine-protein kinase ABL1
Gene Name	ABL1
Pharmacological action	yes
Actions	multitarget
References	Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed Piccaluga PP, Paolini S, Martinelli G: Tyrosine kinase inhibitors for the treatment of Philadelphia chromosome-positive adult acute lymphoblastic leukemia. Cancer. 2007 Sep 15;110(6):1178-86. - Pubmed Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score	1.021
Proto-oncogene tyrosine-protein kinase Src
Name	Proto-oncogene tyrosine-protein kinase Src
Gene Name	SRC
Pharmacological action	yes
Actions	multitarget
References	Kamath AV, Wang J, Lee FY, Marathe PH: Preclinical pharmacokinetics and in vitro metabolism of dasatinib (BMS-354825): a potent oral multi-targeted kinase inhibitor against SRC and BCR-ABL. Cancer Chemother Pharmacol. 2007 Apr 11;. - Pubmed Serrels A, Macpherson IR, Evans TR, Lee FY, Clark EA, Sansom OJ, Ashton GH, Frame MC, Brunton VG: Identification of potential biomarkers for measuring inhibition of Src kinase activity in colon cancer cells following treatment with dasatinib. Mol Cancer Ther. 2006 Dec;5(12):3014-22. Epub 2006 Dec 5. - Pubmed Quintas-Cardama A, Kantarjian H, Cortes J: Targeting ABL and SRC kinases in chronic myeloid leukemia: experience with dasatinib. Future Oncol. 2006 Dec;2(6):655-65. - Pubmed Schittenhelm MM, Shiraga S, Schroeder A, Corbin AS, Griffith D, Lee FY, Bokemeyer C, Deininger MW, Druker BJ, Heinrich MC: Dasatinib (BMS-354825), a dual SRC/ABL kinase inhibitor, inhibits the kinase activity of wild-type, juxtamembrane, and activation loop mutant KIT isoforms associated with human malignancies. Cancer Res. 2006 Jan 1;66(1):473-81. - Pubmed Nam S, Kim D, Cheng JQ, Zhang S, Lee JH, Buettner R, Mirosevich J, Lee FY, Jove R: Action of the Src family kinase inhibitor, dasatinib (BMS-354825), on human prostate cancer cells. Cancer Res. 2005 Oct 15;65(20):9185-9. - Pubmed Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score	1.8207
Ephrin type-A receptor 2
Name	Ephrin type-A receptor 2
Gene Name	EPHA2
Pharmacological action	yes
Actions	antagonist
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed Lindauer M, Hochhaus A: Dasatinib. Recent Results Cancer Res. 2010;184:83-102. - Pubmed
DTHybrid score	0.328
Proto-oncogene tyrosine-protein kinase LCK
Name	Proto-oncogene tyrosine-protein kinase LCK
Gene Name	LCK
Pharmacological action	yes
Actions	multitarget
References	Das J, Chen P, Norris D, Padmanabha R, Lin J, Moquin RV, Shen Z, Cook LS, Doweyko AM, Pitt S, Pang S, Shen DR, Fang Q, de Fex HF, McIntyre KW, Shuster DJ, Gillooly KM, Behnia K, Schieven GL, Wityak J, Barrish JC: 2-aminothiazole as a novel kinase inhibitor template. Structure-activity relationship studies toward the discovery of N-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1- piperazinyl)]-2-methyl-4-pyrimidinyl]amino)]-1,3-thiazole-5-carboxamide (dasatinib, BMS-354825) as a potent pan-Src kinase inhibitor. J Med Chem. 2006 Nov 16;49(23):6819-32. - Pubmed Lindauer M, Hochhaus A: Dasatinib. Recent Results Cancer Res. 2010;184:83-102. - Pubmed Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score	1.4759
Proto-oncogene tyrosine-protein kinase Yes
Name	Proto-oncogene tyrosine-protein kinase Yes
Gene Name	YES1
Pharmacological action	yes
Actions	inhibitor
References	Trevino JG, Summy JM, Lesslie DP, Parikh NU, Hong DS, Lee FY, Donato NJ, Abbruzzese JL, Baker CH, Gallick GE: Inhibition of SRC expression and activity inhibits tumor progression and metastasis of human pancreatic adenocarcinoma cells in an orthotopic nude mouse model. Am J Pathol. 2006 Mar;168(3):962-72. - Pubmed Margutti S, Laufer SA: Are MAP Kinases Drug Targets? Yes, but Difficult Ones. ChemMedChem. 2007 Aug 13;2(8):1116-1140. - Pubmed Lindauer M, Hochhaus A: Dasatinib. Recent Results Cancer Res. 2010;184:83-102. - Pubmed
DTHybrid score	0.3791
Mast/stem cell growth factor receptor
Name	Mast/stem cell growth factor receptor
Gene Name	KIT
Pharmacological action	unknown
Actions	antagonist
References	Schittenhelm MM, Shiraga S, Schroeder A, Corbin AS, Griffith D, Lee FY, Bokemeyer C, Deininger MW, Druker BJ, Heinrich MC: Dasatinib (BMS-354825), a dual SRC/ABL kinase inhibitor, inhibits the kinase activity of wild-type, juxtamembrane, and activation loop mutant KIT isoforms associated with human malignancies. Cancer Res. 2006 Jan 1;66(1):473-81. - Pubmed Shah NP, Lee FY, Luo R, Jiang Y, Donker M, Akin C: Dasatinib (BMS-354825) inhibits KITD816V, an imatinib-resistant activating mutation that triggers neoplastic growth in most patients with systemic mastocytosis. Blood. 2006 Jul 1;108(1):286-91. Epub 2006 Jan 24. - Pubmed Dizdar O, Dede DS, Bulut N, Altundag K: Dasatinib may also inhibit c-Kit in triple negative breast cancer cell lines. Breast Cancer Res Treat. 2007 Mar 10;. - Pubmed
DTHybrid score	0.4483
Beta platelet-derived growth factor receptor
Name	Beta platelet-derived growth factor receptor
Gene Name	PDGFRB
Pharmacological action	unknown
Actions	antagonist
References	Zhang Z, Meier KE: New assignments for multitasking signal transduction inhibitors. Mol Pharmacol. 2006 May;69(5):1510-2. Epub 2006 Feb 23. - Pubmed Chen Z, Lee FY, Bhalla KN, Wu J: Potent inhibition of platelet-derived growth factor-induced responses in vascular smooth muscle cells by BMS-354825 (dasatinib). Mol Pharmacol. 2006 May;69(5):1527-33. Epub 2006 Jan 25. - Pubmed Lindauer M, Hochhaus A: Dasatinib. Recent Results Cancer Res. 2010;184:83-102. - Pubmed
DTHybrid score	0.4271
Signal transducer and activator of transcription 5B
Name	Signal transducer and activator of transcription 5B
Gene Name	STAT5B
Pharmacological action	unknown
Actions	inhibitor
References	Fiskus W, Pranpat M, Balasis M, Bali P, Estrella V, Kumaraswamy S, Rao R, Rocha K, Herger B, Lee F, Richon V, Bhalla K: Cotreatment with vorinostat (suberoylanilide hydroxamic acid) enhances activity of dasatinib (BMS-354825) against imatinib mesylate-sensitive or imatinib mesylate-resistant chronic myelogenous leukemia cells. Clin Cancer Res. 2006 Oct 1;12(19):5869-78. - Pubmed Nam S, Williams A, Vultur A, List A, Bhalla K, Smith D, Lee FY, Jove R: Dasatinib (BMS-354825) inhibits Stat5 signaling associated with apoptosis in chronic myelogenous leukemia cells. Mol Cancer Ther. 2007 Apr;6(4):1400-5. - Pubmed
DTHybrid score	0.3737
Tyrosine-protein kinase ABL2
Name	Tyrosine-protein kinase ABL2
Gene Name	ABL2
Pharmacological action	unknown
Actions	multitarget
References	Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed Lindauer M, Hochhaus A: Dasatinib. Recent Results Cancer Res. 2010;184:83-102. - Pubmed Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score	0.3821
Proto-oncogene tyrosine-protein kinase Fyn
Name	Proto-oncogene tyrosine-protein kinase Fyn
Gene Name	FYN
Pharmacological action	unknown
Actions	multitarget
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed Lindauer M, Hochhaus A: Dasatinib. Recent Results Cancer Res. 2010;184:83-102. - Pubmed Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score	0.3834

Cytochrome P450 3A4
Name	Cytochrome P450 3A4
Gene Name	CYP3A4
Actions	substrate
References	- Wang L, Christopher LJ, Cui D, Li W, Iyer R, Humphreys WG, Zhang D: Identification of the human enzymes involved in the oxidative metabolism of dasatinib: an effective approach for determining metabolite formation kinetics. Drug Metab Dispos. 2008 Sep;36(9):1828-39. Epub 2008 Jun 12. - Pubmed van Erp NP, Gelderblom H, Guchelaar HJ: Clinical pharmacokinetics of tyrosine kinase inhibitors. Cancer Treat Rev. 2009 Dec;35(8):692-706. Epub 2009 Sep 5. - Pubmed Wang L, Christopher LJ, Cui D, Li W, Iyer R, Humphreys WG, Zhang D: Identification of the human enzymes involved in the oxidative metabolism of dasatinib: an effective approach for determining metabolite formation kinetics. Drug Metab Dispos. 2008 Sep;36(9):1828-39. Epub 2008 Jun 12. - Pubmed
DTHybrid score	0.7553
Cytochrome P450 1A1
Name	Cytochrome P450 1A1
Gene Name	CYP1A1
Actions	substrate
References	van Erp NP, Gelderblom H, Guchelaar HJ: Clinical pharmacokinetics of tyrosine kinase inhibitors. Cancer Treat Rev. 2009 Dec;35(8):692-706. Epub 2009 Sep 5. - Pubmed Wang L, Christopher LJ, Cui D, Li W, Iyer R, Humphreys WG, Zhang D: Identification of the human enzymes involved in the oxidative metabolism of dasatinib: an effective approach for determining metabolite formation kinetics. Drug Metab Dispos. 2008 Sep;36(9):1828-39. Epub 2008 Jun 12. - Pubmed
DTHybrid score	0.4125
Cytochrome P450 1A2
Name	Cytochrome P450 1A2
Gene Name	CYP1A2
Actions	substrate
References	van Erp NP, Gelderblom H, Guchelaar HJ: Clinical pharmacokinetics of tyrosine kinase inhibitors. Cancer Treat Rev. 2009 Dec;35(8):692-706. Epub 2009 Sep 5. - Pubmed Wang L, Christopher LJ, Cui D, Li W, Iyer R, Humphreys WG, Zhang D: Identification of the human enzymes involved in the oxidative metabolism of dasatinib: an effective approach for determining metabolite formation kinetics. Drug Metab Dispos. 2008 Sep;36(9):1828-39. Epub 2008 Jun 12. - Pubmed
DTHybrid score	0.5553
Cytochrome P450 1B1
Name	Cytochrome P450 1B1
Gene Name	CYP1B1
Actions	substrate
References	van Erp NP, Gelderblom H, Guchelaar HJ: Clinical pharmacokinetics of tyrosine kinase inhibitors. Cancer Treat Rev. 2009 Dec;35(8):692-706. Epub 2009 Sep 5. - Pubmed Wang L, Christopher LJ, Cui D, Li W, Iyer R, Humphreys WG, Zhang D: Identification of the human enzymes involved in the oxidative metabolism of dasatinib: an effective approach for determining metabolite formation kinetics. Drug Metab Dispos. 2008 Sep;36(9):1828-39. Epub 2008 Jun 12. - Pubmed
DTHybrid score	0.3195
Cytochrome P450 3A5
Name	Cytochrome P450 3A5
Gene Name	CYP3A5
Actions	substrate
References	van Erp NP, Gelderblom H, Guchelaar HJ: Clinical pharmacokinetics of tyrosine kinase inhibitors. Cancer Treat Rev. 2009 Dec;35(8):692-706. Epub 2009 Sep 5. - Pubmed Wang L, Christopher LJ, Cui D, Li W, Iyer R, Humphreys WG, Zhang D: Identification of the human enzymes involved in the oxidative metabolism of dasatinib: an effective approach for determining metabolite formation kinetics. Drug Metab Dispos. 2008 Sep;36(9):1828-39. Epub 2008 Jun 12. - Pubmed
DTHybrid score	0.4735
Dimethylaniline monooxygenase [N-oxide-forming] 3
Name	Dimethylaniline monooxygenase [N-oxide-forming] 3
Gene Name	FMO3
Actions	substrate
References	Wang L, Christopher LJ, Cui D, Li W, Iyer R, Humphreys WG, Zhang D: Identification of the human enzymes involved in the oxidative metabolism of dasatinib: an effective approach for determining metabolite formation kinetics. Drug Metab Dispos. 2008 Sep;36(9):1828-39. Epub 2008 Jun 12. - Pubmed
DTHybrid score	0.2809

Multidrug resistance protein 1
Name	Multidrug resistance protein 1
Gene Name	ABCB1
Actions	substrate,inhibitor
References	Dohse M, Scharenberg C, Shukla S, Robey RW, Volkmann T, Deeken JF, Brendel C, Ambudkar SV, Neubauer A, Bates SE: Comparison of ATP-binding cassette transporter interactions with the tyrosine kinase inhibitors imatinib, nilotinib, and dasatinib. Drug Metab Dispos. 2010 Aug;38(8):1371-80. Epub 2010 Apr 27. - Pubmed Hegedus C, Ozvegy-Laczka C, Apati A, Magocsi M, Nemet K, Orfi L, Keri G, Katona M, Takats Z, Varadi A, Szakacs G, Sarkadi B: Interaction of nilotinib, dasatinib and bosutinib with ABCB1 and ABCG2: implications for altered anti-cancer effects and pharmacological properties. Br J Pharmacol. 2009 Oct;158(4):1153-64. Epub 2009 Sep 28. - Pubmed Giannoudis A, Davies A, Lucas CM, Harris RJ, Pirmohamed M, Clark RE: Effective dasatinib uptake may occur without human organic cation transporter 1 (hOCT1): implications for the treatment of imatinib-resistant chronic myeloid leukemia. Blood. 2008 Oct 15;112(8):3348-54. Epub 2008 Jul 31. - Pubmed
DTHybrid score	0.6204
ATP-binding cassette sub-family G member 2
Name	ATP-binding cassette sub-family G member 2
Gene Name	ABCG2
Actions	substrate,inhibitor
References	Dohse M, Scharenberg C, Shukla S, Robey RW, Volkmann T, Deeken JF, Brendel C, Ambudkar SV, Neubauer A, Bates SE: Comparison of ATP-binding cassette transporter interactions with the tyrosine kinase inhibitors imatinib, nilotinib, and dasatinib. Drug Metab Dispos. 2010 Aug;38(8):1371-80. Epub 2010 Apr 27. - Pubmed Hegedus C, Ozvegy-Laczka C, Apati A, Magocsi M, Nemet K, Orfi L, Keri G, Katona M, Takats Z, Varadi A, Szakacs G, Sarkadi B: Interaction of nilotinib, dasatinib and bosutinib with ABCB1 and ABCG2: implications for altered anti-cancer effects and pharmacological properties. Br J Pharmacol. 2009 Oct;158(4):1153-64. Epub 2009 Sep 28. - Pubmed
DTHybrid score	0.4668

Id	Partner name	Gene Name	Score
4119	Cytochrome P450 2D6	CYP2D6	0.3138
4757	Cytochrome P450 2C9	CYP2C9	0.2892
6016	Cytochrome P450 2C19	CYP2C19	0.2736
4924	Cytochrome P450 2C8	CYP2C8	0.2618
6107	Cytochrome P450 3A7	CYP3A7	0.2395
950	Alpha platelet-derived growth factor receptor	PDGFRA	0.2077
6030	Cytochrome P450 2B6	CYP2B6	0.1725
6013	Cytochrome P450 2E1	CYP2E1	0.1542
6824	Tyrosine-protein kinase Lyn	LYN	0.1388
1735	Canalicular multispecific organic anion transporter 1	ABCC2	0.1204
26	Vascular endothelial growth factor receptor 3	FLT4	0.116
407	Vascular endothelial growth factor receptor 2	KDR	0.1123
32	Vascular endothelial growth factor receptor 1	FLT1	0.112
6022	UDP-glucuronosyltransferase 1-1	UGT1A1	0.1078
2599	Tyrosine-protein kinase HCK	HCK	0.1061
587	Serum albumin	ALB	0.1046
6460	Casein kinase I isoform gamma-3	CSNK1G3	0.1023
862	Multidrug resistance-associated protein 1	ABCC1	0.0951
6544	STE20-like serine/threonine-protein kinase	SLK	0.0931
6546	Dual specificity protein kinase CLK3	CLK3	0.0929
5718	Cytochrome P450 2A6	CYP2A6	0.0929
6545	Calcium/calmodulin-dependent protein kinase type IV	CAMK4	0.0926
5787	Angiopoietin-1 receptor	TEK	0.0892
776	Bile salt export pump	ABCB11	0.0863
1128	Alpha-2-macroglobulin	A2M	0.0851
1490	Solute carrier organic anion transporter family member 1B1	SLCO1B1	0.0845
4177	Proto-oncogene tyrosine-protein kinase receptor ret	RET	0.0836
3462	Tyrosine-protein kinase transforming protein Abl	ABL	0.083
1181	Alpha-1-acid glycoprotein 1	ORM1	0.0817
6508	Putative uncharacterized protein	srtB	0.0786
6543	Putative uncharacterized protein	tcp14	0.0786
6615	Putative uncharacterized protein	MT0785	0.0786
6623	Putative uncharacterized protein	Not Available	0.0786
6806	Putative uncharacterized protein	AGR_C_2535	0.0786
6813	Putative uncharacterized protein	SAV4671	0.0786
6815	Putative uncharacterized protein	AFE_1514	0.0786
6819	Putative uncharacterized protein	RUMGNA_03254	0.0786
6825	Putative uncharacterized protein	CV_3270	0.0786
6808	Transcriptional regulator, GntR family	BCE_3424	0.0786
4579	Serine acetyltransferase	cysE	0.0786
6807	Serine acetyltransferase	cysE	0.0786
2704	Outer-membrane lipoprotein lolB	lolB	0.0785
6805	Outer-membrane lipoprotein lolB	lolB	0.0785
6809	ABC transporter, periplasmic substrate-binding protein	SPO2066	0.0785
6810	Transketolase	tkt2	0.0785
3854	Basic fibroblast growth factor receptor 1	FGFR1	0.0779
20	Prostaglandin G/H synthase 1	PTGS1	0.0757
165	FL cytokine receptor	FLT3	0.0737
844	Epidermal growth factor receptor	EGFR	0.069
823	Fibroblast growth factor receptor 2	FGFR2	0.0685
6804	Profilin-2	PFN2	0.0684
40	RAF proto-oncogene serine/threonine-protein kinase	RAF1	0.0663
6145	Solute carrier family 22 member 1	SLC22A1	0.0654
1618	High affinity nerve growth factor receptor	NTRK1	0.0635
6139	Solute carrier organic anion transporter family member 1A2	SLCO1A2	0.0627
698	B-Raf proto-oncogene serine/threonine-protein kinase	BRAF	0.0615
3856	Fibroblast growth factor receptor 3	FGFR3	0.0614
6104	Dimethylaniline monooxygenase [N-oxide-forming] 1	FMO1	0.0611
6144	Solute carrier family 22 member 2	SLC22A2	0.0596
6018	UDP-glucuronosyltransferase 1-9	UGT1A9	0.0594
2554	Peptidyl-prolyl cis-trans isomerase, mitochondrial	PPIF	0.0581
5798	Mitogen-activated protein kinase 11	MAPK11	0.0567
6106	Cytochrome P450 2C18	CYP2C18	0.0525
951	Macrophage colony-stimulating factor 1 receptor	CSF1R	0.0518
3811	Cytochrome P450 19A1	CYP19A1	0.0509
136	Estrogen receptor	ESR1	0.0472
2164	Multidrug resistance-associated protein 4	ABCC4	0.0465
1729	Solute carrier family 22 member 6	SLC22A6	0.0464
492	Histamine H1 receptor	HRH1	0.0459
2450	Tyrosine-protein kinase ITK/TSK	ITK	0.0449
817	DNA topoisomerase 2-alpha	TOP2A	0.0449
6142	Solute carrier family 22 member 8	SLC22A8	0.0441
871	Glucocorticoid receptor	NR3C1	0.0426
6157	Solute carrier organic anion transporter family member 1B3	SLCO1B3	0.0424
556	Alpha-1A adrenergic receptor	ADRA1A	0.0411
1632	Solute carrier organic anion transporter family member 2B1	SLCO2B1	0.041
885	5-hydroxytryptamine 1B receptor	HTR1B	0.039
831	D(2) dopamine receptor	DRD2	0.0388
290	Prostaglandin G/H synthase 2	PTGS2	0.0385
318	Alpha-2A adrenergic receptor	ADRA2A	0.0376
3947	Xanthine dehydrogenase/oxidase	XDH	0.0374
502	5-hydroxytryptamine 2A receptor	HTR2A	0.0369
2404	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PIK3CG	0.0369
468	Cytochrome P450 4A11	CYP4A11	0.0368
725	5-hydroxytryptamine 1D receptor	HTR1D	0.0365
6148	Multidrug resistance-associated protein 7	ABCC10	0.036
1709	Canalicular multispecific organic anion transporter 2	ABCC3	0.0354
6147	Solute carrier family 22 member 3	SLC22A3	0.0353
824	Sodium-dependent serotonin transporter	SLC6A4	0.0348
2216	Fibroblast growth factor receptor 4	FGFR4	0.0347
6017	Cholesterol side-chain cleavage enzyme, mitochondrial	CYP11A1	0.0346
320	5-hydroxytryptamine 1A receptor	HTR1A	0.0343
6143	Solute carrier family 22 member 7	SLC22A7	0.0341
540	Sodium-dependent noradrenaline transporter	SLC6A2	0.0335
385	Potassium-transporting ATPase alpha chain 1	ATP4A	0.0329
260	Cytochrome P450 51	ERG11	0.0326
761	Cytochrome P450 51	ERG11	0.0326
3163	Cytochrome P450 51	cyp51	0.0326
103	Muscarinic acetylcholine receptor M1	CHRM1	0.0311
3941	Amine oxidase [flavin-containing] A	MAOA	0.0309
118	Organic cation/carnitine transporter 2	SLC22A5	0.0305
632	Alpha-1B adrenergic receptor	ADRA1B	0.03
6094	BCR/ABL fusion protein isoform X9	BCR/ABL fusion	0.0298
101	Potassium voltage-gated channel subfamily H member 2	KCNH2	0.0297
23	D(1A) dopamine receptor	DRD1	0.0291
1864	RET proto-oncogene	RET	0.0287
1950	Epithelial discoidin domain-containing receptor 1	DDR1	0.0286
6170	ATP-binding cassette sub-family A member 3	ABCA3	0.0285
6893	Calcium/calmodulin-dependent protein kinase type II gamma chain	CAMK2G	0.0283
617	Muscarinic acetylcholine receptor M2	CHRM2	0.0282
590	5-hydroxytryptamine 2C receptor	HTR2C	0.0275
220	Sodium channel protein type 5 subunit alpha	SCN5A	0.0274
6782	Ribosomal protein S6 kinase alpha-1	RPS6KA1	0.0273
341	5-hydroxytryptamine 3 receptor	HTR3A	0.0272
193	Beta-1 adrenergic receptor	ADRB1	0.0269
6178	UDP-glucuronosyltransferase 2B7	UGT2B7	0.0269
6137	Multidrug resistance-associated protein 6	ABCC6	0.026
36	Insulin receptor	INSR	0.0258
243	Ribosyldihydronicotinamide dehydrogenase [quinone]	NQO2	0.0254
51	Muscarinic acetylcholine receptor M3	CHRM3	0.0252
1284	Nuclear receptor subfamily 1 group I member 2	NR1I2	0.0251
638	D(3) dopamine receptor	DRD3	0.025
766	Beta-2 adrenergic receptor	ADRB2	0.0244
805	Cytochrome P450 11B1, mitochondrial	CYP11B1	0.0244
6031	Cytochrome P450 3A43	CYP3A43	0.0243
6220	Aryl hydrocarbon receptor	AHR	0.0242
629	Alpha-2B adrenergic receptor	ADRA2B	0.024
567	Receptor tyrosine-protein kinase erbB-2	ERBB2	0.024
731	HIV-1 protease	HIV-1 protease	0.0235
847	Mu-type opioid receptor	OPRM1	0.0233
6025	UDP-glucuronosyltransferase 1-4	UGT1A4	0.0231
1757	Myeloperoxidase	MPO	0.0229
990	Dual specificity mitogen-activated protein kinase kinase 1	MAP2K1	0.0226
340	Apoptotic protease-activating factor 1	APAF1	0.0224
378	Alpha-2C adrenergic receptor	ADRA2C	0.0224
958	Insulin-like growth factor 1 receptor	IGF1R	0.0222
833	Organic cation/carnitine transporter 1	SLC22A4	0.0222
477	DNA topoisomerase 4 subunit A	parC	0.0222
886	DNA topoisomerase 4 subunit A	parC	0.0222
6226	DNA topoisomerase 4 subunit A	parC	0.0222
274	Muscarinic acetylcholine receptor M5	CHRM5	0.0221
476	RAC-alpha serine/threonine-protein kinase	AKT1	0.0218
404	DNA gyrase subunit A	gyrA	0.0218
6224	DNA gyrase subunit A	gyrA	0.0218
450	Muscarinic acetylcholine receptor M4	CHRM4	0.0215
4192	DNA topoisomerase 2-beta	TOP2B	0.0215
869	Estrogen receptor beta	ESR2	0.0213
4115	Voltage-dependent L-type calcium channel subunit alpha-1D	CACNA1D	0.0212
204	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE5A	0.0211
760	Fibroblast growth factor 1	FGF1	0.021
478	Voltage-dependent L-type calcium channel subunit alpha-1C	CACNA1C	0.0207
1353	DNA topoisomerase 1	TOP1	0.0205
3552	DNA topoisomerase 1	topA	0.0205
1721	Glycogen synthase kinase-3 beta	GSK3B	0.0204
2347	Proto-oncogene serine/threonine-protein kinase Pim-1	PIM1	0.0204
465	Calmodulin	CALM1	0.0203
4604	Liver carboxylesterase 1	CES1	0.0203
183	Vascular endothelial growth factor A	VEGFA	0.0203
6176	UDP-glucuronosyltransferase 1-3	UGT1A3	0.0202
4111	Voltage-dependent L-type calcium channel subunit alpha-1S	CACNA1S	0.0202
872	Gamma-aminobutyric-acid receptor subunit alpha-1	GABRA1	0.0202
1024	Solute carrier family 22 member 11	SLC22A11	0.0202
3923	Cholinesterase	BCHE	0.0201
6182	Cytochrome P450 2J2	CYP2J2	0.02
777	Tumor necrosis factor	TNF	0.0199
147	Aldehyde dehydrogenase, mitochondrial	ALDH2	0.0198
486	Serine/threonine-protein kinase ALS2CR7	CDK15	0.0198
510	Serine/threonine-protein kinase receptor R3	ACVRL1	0.0198
395	ALK tyrosine kinase receptor	Not Available	0.0198
483	A-Raf proto-oncogene serine/threonine-protein kinase	ARAF	0.0198
733	Activin receptor type 1B	ACVR1B	0.0198
825	Arsenical pump-driving ATPase	ASNA1	0.0198
3435	Arsenical pump-driving ATPase	arsA	0.0198
745	Anti-Muellerian hormone type-2 receptor	AMHR2	0.0198
154	AFG3-like protein 2	AFG3L2	0.0198
225	NEDD8-activating enzyme E1 regulatory subunit	NAE1	0.0198
2105	ATP-binding cassette sub-family G member 1	ABCG1	0.0198
377	Beta-adrenergic receptor kinase 1	ADRBK1	0.0198
21	Beta-adrenergic receptor kinase 2	ADRBK2	0.0198
2240	Cell division protein kinase 2	CDK2	0.0197
29	Tubulin beta-1 chain	TUBB1	0.0196
1192	Sulfotransferase 1A1	SULT1A1	0.0189
1540	Mitogen-activated protein kinase 14	MAPK14	0.0187
4373	Medium-chain-fatty-acid--CoA ligase	Not Available	0.0187
789	Alpha-1D adrenergic receptor	ADRA1D	0.0187
3390	Aminoglycoside 3'-phosphotransferase	aphA	0.0186
6029	Aminoglycoside 3'-phosphotransferase	aphA1	0.0186
5646	Galactokinase	GALK1	0.0186
5302	TrwB	trwB	0.0186
5265	FtsH	ftsH	0.0186
4110	Voltage-dependent L-type calcium channel subunit beta-2	CACNB2	0.0185
4120	NADPH--cytochrome P450 reductase	POR	0.0184
467	Delta-type opioid receptor	OPRD1	0.0184
292	Activin receptor type-1	ACVR1	0.018
5641	Rod shape-determining protein MreB	TM_0588	0.018
3794	Osmolarity sensor protein envZ	envZ	0.018
4178	DNA repair protein RAD51 homolog 1	RAD51	0.018
5643	General secretion pathway protein E	epsE	0.018
5649	Potassium-transporting ATPase B chain	kdpB	0.018
5644	Sensor protein phoQ	phoQ	0.018
5642	Chaperone clpB	clpB	0.018
5645	DNA topoisomerase 4 subunit B	parE	0.018
6227	DNA topoisomerase 4 subunit B	parE	0.018
849	Activated CDC42 kinase 1	TNK2	0.018
521	ATP-binding cassette transporter sub-family C member 9	ABCC9	0.0179
432	D(4) dopamine receptor	DRD4	0.0179
2236	Casein kinase II subunit alpha	CSNK2A1	0.0178
6014	Cytochrome P450 2A13	CYP2A13	0.0178
4228	Keratin, type II cytoskeletal 7	KRT7	0.0177
756	Sex hormone-binding globulin	SHBG	0.0177
614	Progesterone receptor	PGR	0.0174
964	Voltage-dependent T-type calcium channel subunit alpha-1H	CACNA1H	0.0174
2473	Tyrosine-protein kinase CSK	CSK	0.0174
2398	Tyrosine-protein kinase ZAP-70	ZAP70	0.0173
146	Androgen receptor	AR	0.0173
2184	Cystic fibrosis transmembrane conductance regulator	CFTR	0.0172
16	Adenosine A1 receptor	ADORA1	0.0172
713	Sodium-dependent dopamine transporter	SLC6A3	0.0169
386	Acetyl-coenzyme A synthetase, cytoplasmic	ACSS2	0.0168
704	Long-chain-fatty-acid--CoA ligase 1	ACSL1	0.0168
6141	Sodium/bile acid cotransporter	SLC10A1	0.0168
297	Adenylate cyclase type 1	ADCY1	0.0168
821	Acetyl-coenzyme A synthetase 2-like, mitochondrial	ACSS1	0.0168
5312	Kinesin-like protein KIF1A	KIF1A	0.0168
33	Cystine/glutamate transporter	SLC7A11	0.0168
631	3-hydroxy-3-methylglutaryl-coenzyme A reductase	HMGCR	0.0167
3387	3-hydroxy-3-methylglutaryl-coenzyme A reductase	mvaA	0.0167
1178	Adenosine A2a receptor	ADORA2A	0.0166
716	5-hydroxytryptamine 7 receptor	HTR7	0.0166
289	Cytosolic purine 5'-nucleotidase	NT5C2	0.0163
696	Kappa-type opioid receptor	OPRK1	0.0162
132	ATP-binding cassette sub-family A member 1	ABCA1	0.0161
2852	DNA mismatch repair protein mutL	mutL	0.0161
485	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	PDE3A	0.0159
259	Microsomal triglyceride transfer protein large subunit	MTTP	0.0159
273	Apoptosis regulator Bcl-2	BCL2	0.0158
2615	Chemotaxis protein cheA	cheA	0.0157
2371	Pantothenate kinase	coaA	0.0157
2892	Acetylglutamate kinase	argB	0.0157
3550	Acetylglutamate kinase	argB	0.0157
2867	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase	ispE	0.0157
1881	Hexokinase-1	HK1	0.0157
2950	Inositol-trisphosphate 3-kinase A	ITPKA	0.0157
6433	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4	PFKFB4	0.0156
2397	Dihydroxyacetone kinase	dhaK	0.0156
4751	Mitogen-activated protein kinase 12	MAPK12	0.0156
230	ATP-binding cassette transporter sub-family C member 8	ABCC8	0.0156
1852	Microtubule-associated protein 2	MAP2	0.0151
4203	Histamine N-methyltransferase	HNMT	0.015
3601	Dihydropteroate synthase 1	folP1	0.015
3807	Dihydropteroate synthase 1	folP1	0.015
3808	Dihydropteroate synthase 2	folP2	0.0149
2727	S-adenosylmethionine synthetase	metK	0.0149
748	5'-AMP-activated protein kinase catalytic subunit alpha-1	PRKAA1	0.0149
6832	Serine/threonine-protein kinase SRPK2	SRPK2	0.0148
1256	5-hydroxytryptamine 6 receptor	HTR6	0.0147
6102	Arylamine N-acetyltransferase 2	NAT2	0.0146
6158	Solute carrier organic anion transporter family member 1C1	SLCO1C1	0.0146
3231	Death-associated protein kinase 1	DAPK1	0.0145
2299	UDP-N-acetylmuramate--L-alanine ligase	murC	0.0144
124	Histamine H2 receptor	HRH2	0.0144
2499	Tubulin beta-2C chain	TUBB2C	0.0144
2817	Phosphoribosylglycinamide formyltransferase 2	purT	0.0144
373	Transthyretin	TTR	0.0144
2449	Tubulin alpha-3 chain	TUBA1A	0.0142
661	ADP/ATP translocase 1	SLC25A4	0.0141
198	Sodium channel protein type 10 subunit alpha	SCN10A	0.014
6021	Adenosine kinase	ADK	0.0139
580	Gamma-aminobutyric-acid receptor subunit alpha-3	GABRA3	0.0139
528	5-hydroxytryptamine 1E receptor	HTR1E	0.0139
2530	Protein kinase C theta type	PRKCQ	0.0139
423	Gamma-aminobutyric-acid receptor subunit alpha-2	GABRA2	0.0139
737	Mineralocorticoid receptor	NR3C2	0.0138
232	Corticosteroid-binding globulin	SERPINA6	0.0137
5923	Microtubule-associated protein tau	MAPT	0.0136
5924	Microtubule-associated protein 4	MAP4	0.0136
424	Dihydroorotate dehydrogenase, mitochondrial	DHODH	0.0135
238	Peroxisome proliferator-activated receptor gamma	PPARG	0.0134
117	Sterol O-acyltransferase 1	SOAT1	0.0134
762	Voltage-dependent calcium channel subunit alpha-2/delta-1	CACNA2D1	0.0133
4099	Gamma-aminobutyric-acid receptor subunit beta-3	GABRB3	0.0132
2408	Tyrosine-protein kinase SYK	SYK	0.0132
380	Cytochrome P450 17A1	CYP17A1	0.0131
818	50S ribosomal protein L10	rplJ	0.0131
887	DNA gyrase subunit B	gyrB	0.013
4150	DNA gyrase subunit B	gyrB	0.013
6225	DNA gyrase subunit B	gyrB	0.013
48	Pyridoxal kinase	PDXK	0.013
740	Argininosuccinate synthase	ASS1	0.013
865	Argininosuccinate synthase	ASS1	0.013
2680	Argininosuccinate synthase	argG	0.013
3194	Argininosuccinate synthase	argG	0.013
2511	MAP kinase-activated protein kinase 2	MAPKAPK2	0.013
2251	Thymidylate kinase	tmk	0.0128
2254	Thymidylate kinase	DTYMK	0.0128
3522	Thymidylate kinase	tmk	0.0128
3939	Amine oxidase [flavin-containing] B	MAOB	0.0126
1517	Beta-3 adrenergic receptor	ADRB3	0.0124
242	Asparagine synthetase [glutamine-hydrolyzing]	ASNS	0.0123
535	Voltage-dependent T-type calcium channel subunit alpha-1G	CACNA1G	0.0123
523	Gamma-aminobutyric-acid receptor subunit alpha-5	GABRA5	0.0123
613	Atrial natriuretic peptide receptor A	NPR1	0.0122
122	P2Y purinoceptor 12	P2RY12	0.0122
605	Fumarate reductase flavoprotein subunit	frdA	0.0121
2709	Fumarate reductase flavoprotein subunit	SO_0970	0.0121
3673	Fumarate reductase flavoprotein subunit	fccA	0.0121
4912	Fumarate reductase flavoprotein subunit	ifcA	0.0121
6549	Fumarate reductase flavoprotein subunit	frdA	0.0121
1010	Cytochrome P450 51A1	CYP51A1	0.0121
207	Glutathione synthetase	GSS	0.0121
5269	Glutathione synthetase	gshB	0.0121
102	DNA topoisomerase I, mitochondrial	TOP1MT	0.0121
4148	Serine/threonine-protein kinase mTOR	MTOR	0.0121
3822	Actin, alpha skeletal muscle	ACTA1	0.0119
6023	Cytochrome P450 11B2, mitochondrial	CYP11B2	0.0119
4773	Deoxycytidine kinase	DCK	0.0118
4609	U1 small nuclear ribonucleoprotein A	SNRPA	0.0117
6146	High affinity copper uptake protein 1	SLC31A1	0.0116
904	Glutathione S-transferase P	GSTP1	0.0116
908	Glutathione S-transferase theta-1	GSTT1	0.0115
541	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	PDE4B	0.0114
2157	NAD(P)H dehydrogenase [quinone] 1	NQO1	0.0111
571	Melatonin receptor type 1A	MTNR1A	0.0111
362	Melatonin receptor type 1B	MTNR1B	0.011
1539	Oligopeptide transporter, small intestine isoform	SLC15A1	0.0109
814	Ryanodine receptor 1	RYR1	0.0109
1714	Mitogen-activated protein kinase 3	MAPK3	0.0109
6136	Multidrug resistance-associated protein 5	ABCC5	0.0108
2539	Tubulin alpha-1 chain	TUBA4A	0.0107
2038	Inhibitor of nuclear factor kappa-B kinase subunit beta	IKBKB	0.0107
2180	3-phosphoinositide-dependent protein kinase 1	PDPK1	0.0106
6181	UDP-glucuronosyltransferase 1-8	UGT1A8	0.0106
1629	Transcription factor AP-1	JUN	0.0106
70	Type-1 angiotensin II receptor	AGTR1	0.0106
530	Gamma-aminobutyric-acid receptor subunit alpha-4	GABRA4	0.0105
992	Protein tyrosine kinase 2 beta	PTK2B	0.0104
841	Gamma-aminobutyric-acid receptor subunit alpha-6	GABRA6	0.0104
1836	Mitogen-activated protein kinase 10	MAPK10	0.0103
15	Voltage-dependent T-type calcium channel subunit alpha-1I	CACNA1I	0.0102
4563	Acetyl transferase	rimL	0.0102
2750	Aspartate 1-decarboxylase	panD	0.0102
6150	Solute carrier organic anion transporter family member 4C1	SLCO4C1	0.0101
6177	UDP-glucuronosyltransferase 1-10	UGT1A10	0.01
161	Tubulin beta chain	TUBB	0.0099
312	Tubulin beta chain	TUB2	0.0099
4113	Voltage-dependent L-type calcium channel subunit alpha-1F	CACNA1F	0.0098
163	D(1B) dopamine receptor	DRD5	0.0098
4122	Histone deacetylase 2	HDAC2	0.0098
4100	Gamma-aminobutyric-acid receptor subunit beta-2	GABRB2	0.0098
6599	HTH-type transcriptional regulator ttgR	ttgR	0.0097
80	Peroxisome proliferator-activated receptor alpha	PPARA	0.0097
6154	Multidrug and toxin extrusion protein 1	SLC47A1	0.0097
469	Annexin A1	ANXA1	0.0096
68	Cannabinoid receptor 1	CNR1	0.0096
436	5-hydroxytryptamine 2B receptor	HTR2B	0.0095
952	Dipeptidyl peptidase 4	DPP4	0.0095
142	Gamma-aminobutyric-acid receptor subunit rho-1	GABRR1	0.0095
596	3-oxo-5-alpha-steroid 4-dehydrogenase 1	SRD5A1	0.0094
1569	G1/S-specific cyclin-D1	CCND1	0.0094
3490	Sigma factor sigB regulation protein rsbQ	rsbQ	0.0094
6163	Copper-transporting ATPase 2	ATP7B	0.0094
6165	Copper-transporting ATPase 1	ATP7A	0.0094
239	Coagulation factor X	F10	0.0093
6153	Solute carrier organic anion transporter family member 4A1	SLCO4A1	0.0092
768	FK506-binding protein 1A	FKBP1A	0.0089
3932	Glutathione S-transferase A2	GSTA2	0.0089
6020	Aldehyde oxidase	AOX1	0.0089
474	Acetylcholinesterase	ACHE	0.0089
4600	Malonamidase E2	Not Available	0.0088
734	D1 dopamine receptor-interacting protein calcyon	CALY	0.0088
4160	Voltage-dependent calcium channel subunit alpha-2/delta-2	CACNA2D2	0.0088
6085	Fatty acid-binding protein, intestinal	FABP2	0.0088
1638	Solute carrier family 2, facilitated glucose transporter member 2	SLC2A2	0.0088
4152	Superoxide dismutase [Cu-Zn]	SOD1	0.0087
4237	50S ribosomal protein L22	rplV	0.0087
461	Glycine receptor subunit alpha-3	GLRA3	0.0086
750	Voltage-dependent calcium channel gamma-1 subunit	CACNG1	0.0086
706	Glutamate [NMDA] receptor subunit 3A	GRIN3A	0.0086
4608	Putative cytochrome P450	SCO1207	0.0085
4963	Putative cytochrome P450	SCO2884	0.0085
6254	Putative cytochrome P450	SCO6998	0.0085
790	DNA polymerase subunit alpha B	POLA2	0.0084
896	Glutathione S-transferase Mu 1	GSTM1	0.0084
642	3-oxo-5-alpha-steroid 4-dehydrogenase 2	SRD5A2	0.0083
811	Translocator protein	TSPO	0.0083
1176	Mitogen-activated protein kinase 1	MAPK1	0.0083
511	5-hydroxytryptamine 1F receptor	HTR1F	0.0081
787	Vitamin K epoxide reductase complex subunit 1	VKORC1	0.0081
1971	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	PDE4A	0.0081
360	Ribonucleoside-diphosphate reductase large subunit	RRM1	0.008
6087	Gamma-aminobutyric acid receptor subunit gamma-1	GABRG1	0.0079
6093	Gamma-aminobutyric acid receptor subunit delta	GABRD	0.0079
6089	Gamma-aminobutyric acid receptor subunit epsilon	GABRE	0.0079
6038	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6H	0.0079
84	Nuclear receptor 0B1	NR0B1	0.0078
1656	CYP2B protein	CYP2B	0.0078
2616	Ganglioside GM2 activator	GM2A	0.0078
738	Monocarboxylate transporter 1	SLC16A1	0.0078
164	Histamine H4 receptor	HRH4	0.0077
4098	Gamma-aminobutyric-acid receptor subunit beta-1	GABRB1	0.0077
603	DNA polymerase alpha catalytic subunit	POLA1	0.0074
6766	O-GlcNAcase BT_4395	BT_4395	0.0074
4238	50S ribosomal protein L4	rplD	0.0074
5578	50S ribosomal protein L4	rplD	0.0074
6173	50S ribosomal protein L4	rplD	0.0074
6219	50S ribosomal protein L4	rplD	0.0074
705	Glutamate receptor 1	GRIA1	0.0073
6037	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6G	0.0073
3802	Sodium channel protein type 2 subunit alpha	SCN2A	0.0073
3610	Thioredoxin reductase 1, cytoplasmic	TXNRD1	0.0071
3830	Calreticulin	CALR	0.0071
81	Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial	MCCC2	0.007
547	Propionyl-CoA carboxylase alpha chain, mitochondrial	PCCA	0.007
495	Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial	MCCC1	0.007
177	Biotin--protein ligase	HLCS	0.007
690	Acetyl-CoA carboxylase 1	ACACA	0.007
106	Cannabinoid receptor 2	CNR2	0.007
514	Potassium voltage-gated channel subfamily H member 6	KCNH6	0.007
4112	Voltage-dependent L-type calcium channel subunit beta-4	CACNB4	0.007
4114	Voltage-dependent L-type calcium channel subunit beta-3	CACNB3	0.007
772	Potassium voltage-gated channel subfamily H member 7	KCNH7	0.007
5300	Antigen peptide transporter 1	TAP1	0.007
6040	6-phosphogluconate dehydrogenase, decarboxylating	PGD	0.007
6086	Gamma-aminobutyric acid receptor subunit gamma-2	GABRG2	0.0069
6043	Putative G-protein coupled receptor 44	GPR44	0.0069
6090	Gamma-aminobutyric acid receptor subunit pi	GABRP	0.0069
6092	Gamma-aminobutyric acid receptor subunit rho-2	GABRR2	0.0069
6088	Gamma-aminobutyric acid receptor subunit gamma-3	GABRG3	0.0069
6115	Gamma-aminobutyric acid receptor subunit rho-3	GABRR3	0.0069
244	Angiotensin-converting enzyme	ACE	0.0068
275	Arachidonate 5-lipoxygenase	ALOX5	0.0068
723	Cytosolic phospholipase A2	PLA2G4A	0.0067
105	Sodium-dependent multivitamin transporter	SLC5A6	0.0067
5934	Cytochrome P450 26A1	CYP26A1	0.0067
4311	tRNA	TRDMT1	0.0066
4325	tRNA	trmD	0.0066
4328	tRNA	trmD	0.0066
6034	Hydroxyindole O-methyltransferase	ASMT	0.0066
6035	Nuclear receptor ROR-beta	RORB	0.0066
6036	Eosinophil peroxidase	EPX	0.0066
1650	Heme carrier protein 1	SLC46A1	0.0066
5251	Carbonyl reductase [NADPH] 1	CBR1	0.0065
2112	Toll-like receptor 9	TLR9	0.0065
3957	Adenosine deaminase	ADA	0.0065
3970	Voltage-dependent N-type calcium channel subunit alpha-1B	CACNA1B	0.0065
6155	ATP-binding cassette transporter sub-family C member 11	ABCC11	0.0065
4095	Neuronal acetylcholine receptor subunit alpha-7	CHRNA7	0.0065
947	Neuronal acetylcholine receptor subunit alpha-4	CHRNA4	0.0065
3804	Sodium channel protein type 4 subunit alpha	SCN4A	0.0064
1820	Beta-nerve growth factor	NGF	0.0064
6091	Gamma-aminobutyric acid receptor subunit theta	GABRQ	0.0063
333	Voltage-dependent L-type calcium channel subunit beta-1	CACNB1	0.0063
6068	Guanylate cyclase soluble subunit alpha-2	GUCY1A2	0.0063
3432	Multidrug-efflux transporter 1 regulator	bmrR	0.0063
4476	Mannitol dehydrogenase	mtlD	0.0063
1974	Oligopeptide transporter, kidney isoform	SLC15A2	0.0063
427	Substance-P receptor	TACR1	0.0062
7	Nitric oxide synthase, inducible	NOS2	0.0062
1502	Peroxisome proliferator-activated receptor delta	PPARD	0.0062
813	Neuronal acetylcholine receptor subunit alpha-2	CHRNA2	0.0062
1787	Nuclear factor NF-kappa-B p105 subunit	NFKB1	0.0061
176	30S ribosomal protein S10	rpsJ	0.006
6175	30S ribosomal protein S10	rpsJ	0.006
4117	Probable pyruvate-flavodoxin oxidoreductase	ydbK	0.006
601	Propionyl-CoA carboxylase beta chain, mitochondrial	PCCB	0.006
185	Vasopressin V1a receptor	AVPR1A	0.006
820	Glycine receptor subunit alpha-2	GLRA2	0.0059
462	Intermediate conductance calcium-activated potassium channel protein 4	KCNN4	0.0058
322	Vasopressin V2 receptor	AVPR2	0.0058
268	Adenosine A2b receptor	ADORA2B	0.0058
606	Cytochrome P450 27, mitochondrial	CYP27A1	0.0058
2222	Equilibrative nucleoside transporter 1	SLC29A1	0.0057
765	Indoleamine 2,3-dioxygenase	IDO1	0.0057
685	Oxygen-insensitive NADPH nitroreductase	nfsA	0.0057
6945	Oxygen-insensitive NADPH nitroreductase	rdxA	0.0057
284	DNA-directed RNA polymerase beta chain	rpoB	0.0056
5773	DNA-directed RNA polymerase beta chain	rpoB	0.0056
610	Calcium-activated potassium channel subunit alpha 1	KCNMA1	0.0056
771	Pyruvate carboxylase, mitochondrial	PC	0.0056
3917	Methylenetetrahydrofolate reductase	MTHFR	0.0055
94	5-hydroxytryptamine 4 receptor	HTR4	0.0054
6180	UDP-glucuronosyltransferase 2B4	UGT2B4	0.0054
295	Carbonic anhydrase 1	CA1	0.0054
54	Prothrombin	F2	0.0054
5998	Toll-like receptor 8	TLR8	0.0053
158	Sodium channel protein type 1 subunit alpha	SCN1A	0.0052
6228	Nuclear receptor coactivator 1	NCOA1	0.0052
6339	Ig kappa chain V-II region RPMI 6410	Not Available	0.0052
565	Extracellular calcium-sensing receptor	CASR	0.0052
918	Glutamate receptor, ionotropic kainate 2	GRIK2	0.0052
712	Tubulin alpha chain	TUB1	0.0052
6079	Neuronal acetylcholine receptor subunit alpha-3	CHRNA3	0.0052
775	Acetyl-CoA carboxylase 2	ACACB	0.0052
806	Sodium/potassium-transporting ATPase alpha-1 chain	ATP1A1	0.0051
4103	Proteasome subunit beta type 2	PSMB2	0.0051
4102	Proteasome subunit beta type 5	PSMB5	0.0051
4101	Proteasome subunit beta type 1	PSMB1	0.0051
6755	Poliovirus receptor	PVR	0.0051
6045	Voltage-dependent calcium channel subunit alpha-2/delta-3	CACNA2D3	0.005
778	Cysteinyl leukotriene receptor 1	CYSLTR1	0.0049
856	Vitamin D3 receptor	VDR	0.0049
1995	Sodium channel protein type 9 subunit alpha	SCN9A	0.0048
24	Thymidylate synthase	TMP1	0.0048
359	Thymidylate synthase	TYMS	0.0048
2626	Thymidylate synthase	thyA	0.0048
2729	Thymidylate synthase	thyA	0.0048
5352	Thymidylate synthase	THYA	0.0048
921	Glutamate receptor 2	GRIA2	0.0048
464	Glutamate [NMDA] receptor subunit epsilon-2	GRIN2B	0.0047
3809	Estrogen-related receptor gamma	ESRRG	0.0047
683	Potassium transporter	GK0582	0.0047
1759	85 kDa calcium-independent phospholipase A2	PLA2G6	0.0046
1770	Phospholipase C	PLCL1	0.0046
2841	Phospholipase C	plc	0.0046
858	Potassium voltage-gated channel subfamily A member 1	KCNA1	0.0046
780	Retinoic acid receptor RXR-gamma	RXRG	0.0046
976	Platelet glycoprotein IX	GP9	0.0046
173	Toll-like receptor 7	TLR7	0.0046
6172	ATP-binding cassette sub-family B member 8, mitochondrial	ABCB8	0.0045
6167	Organic solute transporter subunit beta	OSTB	0.0045
6166	Organic solute transporter subunit alpha	OSTA	0.0045
6044	Serum paraoxonase/lactonase 3	PON3	0.0045
3937	Fatty-acid amide hydrolase	FAAH	0.0045
6169	ATP-binding cassette sub-family A member 5	ABCA5	0.0044
6160	Solute carrier organic anion transporter family member 3A1	SLCO3A1	0.0044
78	Acetyl-CoA acetyltransferase, mitochondrial	ACAT1	0.0044
6078	Neuronal acetylcholine receptor subunit beta-4	CHRNB4	0.0044
702	UMP-CMP kinase	CMPK1	0.0044
4210	Toll-like receptor 4	TLR4	0.0044
6138	Multidrug resistance protein 3	ABCB4	0.0043
3810	Catechol O-methyltransferase	COMT	0.0042
714	Glutathione reductase, mitochondrial	GSR	0.0042
88	Retinoic acid receptor RXR-beta	RXRB	0.0042
890	Niemann-Pick C1-like protein 1	NPC1L1	0.0042
394	Calcineurin subunit B isoform 1	PPP3R1	0.0041
6753	Apolipoprotein M	APOM	0.0041
6742	Recoverin	RCVRN	0.0041
6752	Guanylyl cyclase-activating protein 1	GUCA1A	0.0041
6747	Chalcone/stilbene synthase family protein	MT1417	0.0041
6743	Non-fluorescent flavoprotein	luxF	0.0041
2528	Fatty acid metabolism regulator protein	fadR	0.0041
6740	Fatty acid metabolism regulator protein	fadR	0.0041
6522	Hepatocyte nuclear factor 4-alpha	HNF4A	0.0041
6751	Gag polyprotein	gag	0.0041
6741	Peroxisomal 3,2-trans-enoyl-CoA isomerase	PECI	0.0041
6746	Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	PPP3CA	0.0041
6749	Polyprotein	Not Available	0.0041
6206	DNA-directed RNA polymerase subunit beta'	rpoC	0.0041
3997	Cytochrome P450 24A1, mitochondrial	CYP24A1	0.0041
6046	Voltage-gated calcium channel beta 1 subunit splice variant CavB1d	CACNB1	0.004
592	Carbonic anhydrase 4	CA4	0.004
6032	PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE)	fas	0.004
2297	Genome polyprotein	Not Available	0.004
2322	Genome polyprotein	Not Available	0.004
2694	Genome polyprotein	Not Available	0.004
2719	Genome polyprotein	Not Available	0.004
2860	Genome polyprotein	Not Available	0.004
2928	Genome polyprotein	Not Available	0.004
3160	Genome polyprotein	Not Available	0.004
3260	Genome polyprotein	Not Available	0.004
4783	Genome polyprotein	Not Available	0.004
5726	Genome polyprotein	Not Available	0.004
5779	Genome polyprotein	Not Available	0.004
5867	Genome polyprotein	Not Available	0.004
6253	Genome polyprotein	Not Available	0.004
6301	Genome polyprotein	Not Available	0.004
6380	Genome polyprotein	Not Available	0.004
6381	Genome polyprotein	Not Available	0.004
6437	Genome polyprotein	Not Available	0.004
6520	Genome polyprotein	Not Available	0.004
6521	Genome polyprotein	Not Available	0.004
6652	Genome polyprotein	Not Available	0.004
6734	Genome polyprotein	Not Available	0.004
6735	Genome polyprotein	Not Available	0.004
6736	Genome polyprotein	Not Available	0.004
6737	Genome polyprotein	Not Available	0.004
6738	Genome polyprotein	Not Available	0.004
6739	Genome polyprotein	Not Available	0.004
6744	Genome polyprotein	Not Available	0.004
6748	Genome polyprotein	Not Available	0.004
6894	Genome polyprotein	Not Available	0.004
6898	Genome polyprotein	Not Available	0.004
564	Cellular retinoic acid-binding protein 1	CRABP1	0.004
5432	Trafficking protein particle complex subunit 3	TRAPPC3	0.0039
319	Opioid receptor, sigma 1	OPRS1	0.0039
650	Aldo-keto reductase family 1 member C3	AKR1C3	0.0039
5294	Nucleoside diphosphate kinase A	NME1	0.0039
4146	Phosphatidylinositol 3-kinase regulatory subunit gamma	PIK3R3	0.0039
4145	Phosphatidylinositol 3-kinase regulatory subunit beta	PIK3R2	0.0039
1129	C-C chemokine receptor type 5	CCR5	0.0039
1561	Troponin C, slow skeletal and cardiac muscles	TNNC1	0.0039
365	Dihydrofolate reductase	DHFR	0.0039
2381	Dihydrofolate reductase	DFR1	0.0039
2833	Dihydrofolate reductase	Not Available	0.0039
2931	Dihydrofolate reductase	folA	0.0039
3544	Dihydrofolate reductase	folA	0.0039
3682	Dihydrofolate reductase	folA	0.0039
6642	Dihydrofolate reductase	folA	0.0039
6756	Dihydrofolate reductase	dfrA	0.0039
337	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial	NDUFS7	0.0039
214	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	NDUFS3	0.0039
803	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	NDUFS2	0.0039
859	Cellular retinoic acid-binding protein 2	CRABP2	0.0038
6168	Solute carrier family 22 member 16	SLC22A16	0.0038
1760	Aminopeptidase N	ANPEP	0.0038
6843	Aminopeptidase N	pepN	0.0038
1050	Bile salt sulfotransferase	SULT2A1	0.0038
6861	Alcohol dehydrogenase [NADP+]	AKR1A1	0.0037
153	Dopamine beta-hydroxylase	DBH	0.0036
458	Neuronal acetylcholine receptor subunit alpha-10	CHRNA10	0.0036
522	26S proteasome non-ATPase regulatory subunit 2	PSMD2	0.0036
515	26S proteasome non-ATPase regulatory subunit 1	PSMD1	0.0036
392	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	CACNA1A	0.0036
5961	Insulin	INS	0.0036
6047	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	PDE1A	0.0036
6527	Lymphocyte antigen 96	LY96	0.0036
482	Glycine receptor subunit alpha-1	GLRA1	0.0035
2091	Endoplasmin	HSP90B1	0.0035
276	Sodium- and chloride-dependent GABA transporter 1	SLC6A1	0.0035
6432	Transporter	snf	0.0035
1374	Natriuretic peptides B	NPPB	0.0035
6161	Probable low affinity copper uptake protein 2	SLC31A2	0.0035
1827	Gap junction alpha-1 protein	GJA1	0.0035
1908	Vascular cell adhesion protein 1	VCAM1	0.0035
939	50S ribosomal protein L3	rplC	0.0035
293	Gamma-glutamyl hydrolase	GGH	0.0035
569	Retinal dehydrogenase 2	ALDH1A2	0.0035
1483	Membrane copper amine oxidase	AOC3	0.0035
6140	Ileal sodium/bile acid cotransporter	SLC10A2	0.0034
581	Cytochrome P450 2R1	CYP2R1	0.0034
5692	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	PDE1B	0.0034
131	Synaptic vesicular amine transporter	SLC18A2	0.0034
6149	Solute carrier family 22 member 10	SLC22A10	0.0034
6179	UDP-glucuronosyltransferase 2B17	UGT2B17	0.0033
6750	ADP-ribosylation factor 6	ARF6	0.0033
1281	Phosphatidylinositol 3-kinase regulatory subunit alpha	PIK3R1	0.0033
5626	Nucleoside diphosphate kinase B	NME2	0.0033
6524	Protein tonB	tonB	0.0033
6152	Solute carrier organic anion transporter family member 2A1	SLCO2A1	0.0033
6174	50S ribosomal protein L32	rpmF	0.0032
611	Retinal dehydrogenase 1	ALDH1A1	0.0032
162	Retinoic acid receptor gamma-1	RARG	0.0032
6105	3-oxo-5-beta-steroid 4-dehydrogenase	AKR1D1	0.0032
6316	ADP-ribosylation factor 1	ARF1	0.0032
3086	Plasmepsin-2	Not Available	0.0032
2107	Microtubule-associated protein 1A	MAP1A	0.0032
140	30S ribosomal protein S9	rpsI	0.0031
6719	30S ribosomal protein S9	rpsI	0.0031
6725	30S ribosomal protein S9	rpsI	0.0031
208	DNA-directed RNA polymerase beta' chain	rpoC	0.0031
5774	DNA-directed RNA polymerase beta' chain	rpoC	0.0031
2578	Tubulin beta-3 chain	TUBB3	0.003
2285	Streptogramin A acetyltransferase	vatD	0.003
357	Carbonic anhydrase 2	CA2	0.003
543	Penicillin-binding protein 1B	mrcB	0.003
6186	Penicillin-binding protein 1B	ponB	0.003
6822	Penicillin-binding protein 1b	pbp1b	0.003
6844	Penicillin-binding protein 1b	pbp1b	0.003
741	Potassium voltage-gated channel subfamily KQT member 1	KCNQ1	0.003
6241	Nuclear receptor coactivator 2	NCOA2	0.003
2435	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase	lpxC	0.003
6613	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase	lpxC	0.003
194	NADH dehydrogenase [ubiquinone] 1 subunit C2	NDUFC2	0.003
159	Penicillin-binding protein 2B	penA	0.0029
6121	Penicillin-binding protein 2B	penA	0.0029
1086	Potassium voltage-gated channel subfamily KQT member 2	KCNQ2	0.0029
3868	Calcineurin subunit B isoform 2	PPP3R2	0.0029
421	Calcium signal-modulating cyclophilin ligand	CAMLG	0.0029
3950	Cell division protein kinase 9	CDK9	0.0029
3968	Cell division protein kinase 8	CDK8	0.0029
822	Aldose reductase	AKR1B1	0.0029
796	Inosine-5'-monophosphate dehydrogenase 2	IMPDH2	0.0029
838	Inosine-5'-monophosphate dehydrogenase 1	IMPDH1	0.0029
291	Nitric-oxide synthase, endothelial	NOS3	0.0029
781	ATP-sensitive inward rectifier potassium channel 11	KCNJ11	0.0029
512	DNA-directed RNA polymerase alpha chain	rpoA	0.0029
5772	DNA-directed RNA polymerase alpha chain	rpoA	0.0029
1525	Heparin-binding growth factor 2	FGF2	0.0028
1435	Synaptic vesicle glycoprotein 2A	SV2A	0.0028
1457	Long-chain-fatty-acid--CoA ligase 4	ACSL4	0.0028
634	Squalene monooxygenase	SQLE	0.0027
7196	Squalene monooxygenase	ERG1	0.0027
73	Prostaglandin E2 receptor, EP1 subtype	PTGER1	0.0027
6232	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	GNAS	0.0027
6233	Adenylate cyclase type 2	ADCY2	0.0027
6234	Adenylate cyclase type 5	ADCY5	0.0027
4217	Telomerase reverse transcriptase	TERT	0.0027
4173	Tyrosine-protein kinase JAK2	JAK2	0.0027
4366	Riboflavin kinase/FMN adenylyltransferase	TM_0857	0.0027
3849	Insulin-like growth factor-binding protein 7	IGFBP7	0.0027
2009	Protein NOV homolog	NOV	0.0027
3847	Neuroendocrine convertase 2	PCSK2	0.0027
1949	Carboxypeptidase E	CPE	0.0027
3850	Synaptotagmin-like protein 4	SYTL4	0.0027
3848	Neuroendocrine convertase 1	PCSK1	0.0027
3846	Retinoblastoma-associated protein	RB1	0.0027
6263	cAMP-dependent protein kinase catalytic subunit alpha	PRKACA	0.0027
770	Retinoic acid-induced protein 3	GPRC5A	0.0027
719	Retinoic acid receptor responder protein 1	RARRES1	0.0027
6098	Potassium voltage-gated channel subfamily D member 2	KCND2	0.0027
6099	Potassium voltage-gated channel subfamily D member 3	KCND3	0.0027
864	Gag-Pol polyprotein	gag-pol	0.0026
2237	Gag-Pol polyprotein	gag-pol	0.0026
2326	Gag-Pol polyprotein	gag-pol	0.0026
2451	Gag-Pol polyprotein	gag-pol	0.0026
2901	Gag-Pol polyprotein	gag-pol	0.0026
3165	Gag-Pol polyprotein	gag-pol	0.0026
3722	Gag-Pol polyprotein	gag-pol	0.0026
6306	Gag-Pol polyprotein	gag-pol	0.0026
6624	Gag-Pol polyprotein	gag-pol	0.0026
1648	Elastin	ELN	0.0026
444	Alcohol dehydrogenase 1B	ADH1B	0.0026
5997	Tumor necrosis factor ligand superfamily member 11	TNFSF11	0.0026
804	Mitochondrial folate transporter/carrier	SLC25A32	0.0026
718	Folate receptor gamma	FOLR3	0.0026
299	Folate receptor beta	FOLR2	0.0026
49	Endothelin B receptor	EDNRB	0.0026
5304	UPF0166 protein TM_0021	TM_0021	0.0025
5293	Shikimate kinase 2	aroL	0.0025
5266	Activator of	hgdC	0.0025
5287	Signaling protein	Not Available	0.0025
5314	UPF0079 ATP-binding protein HI0065	HI_0065	0.0025
5292	Putative partitioning protein	TT_C1605	0.0025
3199	Phosphopantetheine adenylyltransferase	coaD	0.0025
3543	Phosphopantetheine adenylyltransferase	coaD	0.0025
3567	Phosphopantetheine adenylyltransferase	coaD	0.0025
5289	Phosphopantetheine adenylyltransferase	coaD	0.0025
5281	Plasmid segregation protein parM	parM	0.0025
2874	Nitrogenase iron protein 1	nifH1	0.0025
4346	Polynucleotide kinase	pseT	0.0025
5283	D-alanine--D-alanine ligase B	ddlB	0.0025
5288	Shikimate kinase	aroK	0.0025
5305	Phosphoribosylaminoimidazole carboxylase ATPase subunit	purK	0.0025
5299	D-alanine--D-alanine ligase	ddl	0.0025
6598	D-alanine--D-alanine ligase	ddl	0.0025
5275	Multidrug resistance ABC transporter ATP-binding and permease protein	lmrA	0.0025
5276	Chromosomal replication initiator protein dnaA	dnaA	0.0025
5315	Chaperone protein htpG	htpG	0.0025
5270	ATP-dependent Clp protease ATP-binding subunit clpX	clpX	0.0025
5259	Transcriptional regulator	ntrC1	0.0025
6699	Transcriptional regulator	Cgl2612	0.0025
5290	ATP-dependent hsl protease ATP-binding subunit hslU	hslU	0.0025
5638	ATP-dependent hsl protease ATP-binding subunit hslU	hslU	0.0025
5284	Large T antigen	Not Available	0.0025
5291	Glycogen synthase 1	glgA1	0.0025
5264	DNA replication protein	REP	0.0025
4794	Phosphoenolpyruvate carboxykinase [ATP]	pckA	0.0025
5285	Kinesin heavy chain	KIF5B	0.0025
1549	Heat shock 70 kDa protein 1	HSPA1A	0.0025
3777	ATP-dependent Clp protease ATP-binding subunit clpA	clpA	0.0025
3982	Phosphoribosylformylglycinamidine synthase	PFAS	0.0025
5261	Phosphoribosylformylglycinamidine synthase	purL	0.0025
5277	Preprotein translocase subunit secA	secA	0.0025
5308	Preprotein translocase secA 1 subunit	secA1	0.0025
6859	Protein S100-A4	S100A4	0.0025
3959	Cell division protein kinase 4	CDK4	0.0025
76	Nitric-oxide synthase, brain	NOS1	0.0025
251	Alcohol dehydrogenase 1A	ADH1A	0.0025
1385	Angiotensin-converting enzyme 2	ACE2	0.0025
5880	Thrombopoietin receptor	MPL	0.0025
6837	Serine/threonine-protein kinase 17B	STK17B	0.0025
6836	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial	HIBCH	0.0025
459	Retinoic acid receptor RXR-alpha	RXRA	0.0025
390	Adenosine A3 receptor	ADORA3	0.0025
3482	Cell division protein kinase 7	CDK7	0.0025
1939	Heat shock protein HSP 90-alpha	HSP90AA1	0.0025
1275	Estrogen sulfotransferase	SULT1E1	0.0025
2697	Uridine-cytidine kinase 2	UCK2	0.0024
6123	Carbonic anhydrase 5A, mitochondrial	CA5A	0.0024
400	Coagulation factor IX	F9	0.0024
5461	Coagulation factor IX	F9	0.0024
578	Endothelin-1 receptor	EDNRA	0.0024
4226	Uridine phosphorylase 2	UPP2	0.0024
544	Potassium voltage-gated channel subfamily E member 1	KCNE1	0.0024
6039	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	PDE11A	0.0024
233	Potassium channel subfamily K member 2	KCNK2	0.0024
6070	Nischarin	NISCH	0.0024
5852	Type-2 angiotensin II receptor	AGTR2	0.0024
6171	Solute carrier family 28 member 3	SLC28A3	0.0024
3955	Cell division protein kinase 6	CDK6	0.0023
4221	Vascular endothelial growth factor	VEGF	0.0023
5816	Cadherin-5	CDH5	0.0023
550	Amiloride-sensitive sodium channel subunit delta	SCNN1D	0.0023
27	Amiloride-sensitive sodium channel subunit beta	SCNN1B	0.0023
552	Amiloride-sensitive sodium channel subunit gamma	SCNN1G	0.0023
213	Amiloride-sensitive sodium channel subunit alpha	SCNN1A	0.0023
1830	5'-nucleotidase	NT5E	0.0023
267	Plasminogen activator inhibitor 1	SERPINE1	0.0023
2427	Ferrichrome-iron receptor	fhuA	0.0023
1524	Peptidyl-prolyl cis-trans isomerase A	PPIA	0.0023
6700	Peptidyl-prolyl cis-trans isomerase A	ppiA	0.0023
751	Potassium channel subfamily K member 6	KCNK6	0.0023
342	P protein [Includes: DNA-directed DNA polymerase	P	0.0023
612	P protein [Includes: DNA-directed DNA polymerase	P	0.0023
137	FolC bifunctional protein [Includes: Folylpolyglutamate synthase	folC	0.0023
6126	Carbonic anhydrase 7	CA7	0.0023
4225	Uridine phosphorylase 1	UPP1	0.0022
4081	Vitamin K epoxide reductase complex subunit 1-like protein 1	VKORC1L1	0.0022
604	Vitamin K-dependent protein Z	PROZ	0.0022
1992	Vitamin D-binding protein	GC	0.0022
677	Choline-phosphate cytidylyltransferase A	PCYT1A	0.0022
6111	DNA polymerase epsilon subunit 4	POLE4	0.0022
6112	DNA polymerase epsilon subunit 3	POLE3	0.0022
6110	DNA polymerase epsilon subunit 2	POLE2	0.0022
6108	Ribonucleoside-diphosphate reductase subunit M2 B	RRM2B	0.0022
6109	DNA polymerase epsilon catalytic subunit A	POLE	0.0022
6656	UDP-glucuronosyltransferase 3A1	UGT3A1	0.0022
6131	Carbonic anhydrase 14	CA14	0.0022
695	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	PDE10A	0.0022
2320	Thymidine kinase, cytosolic	TK1	0.0022
5278	Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1	PAPSS1	0.0022
3961	G protein-activated inward rectifier potassium channel 4	KCNJ5	0.0022
2155	Insulin-degrading enzyme	IDE	0.0022
1196	Complement decay-accelerating factor	CD55	0.0022
298	Renin	REN	0.0021
6506	Stathmin-4	STMN4	0.0021
517	Alcohol dehydrogenase 1C	ADH1C	0.0021
1630	Integrin beta-2	ITGB2	0.0021
1244	Low-density lipoprotein receptor-related protein 2	LRP2	0.0021
172	Potassium channel subfamily K member 1	KCNK1	0.0021
620	Bifunctional dihydrofolate reductase-thymidylate synthase	Not Available	0.0021
6264	cAMP-dependent protein kinase inhibitor alpha	PKIA	0.0021
280	4-aminobutyrate aminotransferase, mitochondrial	ABAT	0.0021
413	Amidophosphoribosyltransferase	PPAT	0.0021
2515	Amidophosphoribosyltransferase	purF	0.0021
3714	Amidophosphoribosyltransferase	purF	0.0021
3876	Aromatic-L-amino-acid decarboxylase	DDC	0.0021
6221	Steroid hormone receptor ERR1	ESRRA	0.0021
594	Thyroxine-binding globulin	SERPINA7	0.0021
3470	Hypothetical protein MG245 homolog	MPN_348	0.0021
6277	Heat shock cognate 71 kDa protein	HSPA8	0.0021
5189	Trimethylamine dehydrogenase	tmd	0.002
4106	Guanylate kinase	GUK1	0.002
4516	Guanylate kinase	gmk	0.002
4837	Cag-alfa	cag-alfa	0.002
4774	NTPase P4	Not Available	0.002
4839	DNA polymerase III subunit tau	dnaX	0.002
422	Vitamin K-dependent protein C	PROC	0.002
4838	PMS1 protein homolog 2	PMS2	0.002
1245	Vitamin K-dependent protein S	PROS1	0.002
2270	Dephospho-CoA kinase	coaE	0.002
2284	Adenylate kinase	adk	0.002
2296	Adenylate kinase	adk	0.002
2311	Adenylate kinase	adk	0.002
2312	Adenylate kinase	Not Available	0.002
5295	2-keto-3-deoxy-gluconate kinase	TT_P0036	0.002
2751	Holliday junction ATP-dependent DNA helicase ruvB	ruvB	0.002
4755	Holliday junction ATP-dependent DNA helicase ruvB	ruvB	0.002
3426	Glutamine synthetase	glnA	0.002
3987	Glutamine synthetase	GLUL	0.002
3175	Glutamate--cysteine ligase	gshA	0.002
6122	Carbonic anhydrase 3	CA3	0.002
1742	D-HSCDK2	CDK2deltaT	0.002
1771	Cell division control protein 2 homolog	CDK1	0.002
3321	Cell division control protein 2 homolog	CRK2	0.002
4218	Ribonucleoside-diphosphate reductase M2 subunit	RRM2	0.002
6080	Neuronal acetylcholine receptor subunit alpha-5	CHRNA5	0.002
6082	Neuronal acetylcholine receptor subunit beta-3	CHRNB3	0.002
948	Neuronal acetylcholine receptor subunit beta-2	CHRNB2	0.002
1058	Cell division protein kinase 5	CDK5	0.002
4199	Sphingosine 1-phosphate receptor Edg-8	S1PR5	0.002
633	Penicillin-binding proteins 1A/1B	pbpA	0.0019
489	Monocarboxylate transporter 2	SLC16A7	0.0019
2683	Mono-ADP-ribosyltransferase C3	C3	0.0019
389	Amiloride-sensitive cation channel 2, neuronal	ACCN2	0.0019
758	Thyroid hormone receptor alpha	THRA	0.0019
217	Estradiol 17-beta-dehydrogenase 1	HSD17B1	0.0019
2808	Chloramphenicol acetyltransferase 3	cat3	0.0019
174	Sigma 1-type opioid receptor	SIGMAR1	0.0019
5271	Focal adhesion kinase 1	PTK2	0.0018
518	Peroxidase/catalase T	katG	0.0018
4162	Potassium voltage-gated channel subfamily KQT member 3	KCNQ3	0.0018
2390	Nonsecretory ribonuclease	RNASE2	0.0018
2922	Glycerol kinase	glpK	0.0018
6081	Neuronal acetylcholine receptor subunit alpha-6	CHRNA6	0.0018
448	Vitamin K-dependent gamma-carboxylase	GGCX	0.0018
4097	Neuronal acetylcholine receptor subunit alpha-9	CHRNA9	0.0018
6048	Troponin C, skeletal muscle	TNNC2	0.0018
6344	ATP synthase subunit gamma, mitochondrial	ATP5C1	0.0018
6343	ATP synthase subunit beta, mitochondrial	ATP5B	0.0018
6342	ATP synthase subunit alpha, mitochondrial	ATP5A1	0.0018
1968	ATP-sensitive inward rectifier potassium channel 12	KCNJ12	0.0018
67	Prolyl 4-hydroxylase subunit alpha-1	P4HA1	0.0017
3587	Gastrotropin	FABP6	0.0017
621	Periplasmic [Fe] hydrogenase 1	Not Available	0.0017
5682	Ribonuclease pancreatic	RNASE1	0.0017
229	Retinoic acid receptor beta	RARB	0.0017
3639	Thymidine phosphorylase	deoA	0.0017
3936	Thymidine phosphorylase	TYMP	0.0017
6857	[Pyruvate dehydrogenase [lipoamide]] kinase isozyme 2, mitochondrial	PDK2	0.0017
408	Riboflavin kinase	RFK	0.0017
2417	Chloramphenicol acetyltransferase	cat	0.0017
3278	Chloramphenicol acetyltransferase	cat	0.0017
2282	Protein recA	recA	0.0017
2315	Protein recA	recA	0.0017
2332	Protein recA	recA	0.0017
5263	Protein recA	recA	0.0017
346	Thyroid hormone receptor beta-1	THRB	0.0017
3669	Ribokinase	rbsK	0.0017
563	Thyroid peroxidase	TPO	0.0017
730	Retinoic acid receptor alpha	RARA	0.0017
2810	Dr hemagglutinin structural subunit	draA	0.0017
2981	Phospholipase A2, membrane associated	PLA2G2A	0.0017
1302	Dihydropyrimidine dehydrogenase [NADP+]	DPYD	0.0017
2718	Chloramphenicol 3-O phosphotransferase	Not Available	0.0017
144	Hemoglobin subunit alpha	HBA1	0.0017
215	Sodium channel protein type 11 subunit alpha	SCN11A	0.0017
241	Calcium-transporting ATPase type 2C member 1	ATP2C1	0.0016
798	Osteocalcin	BGLAP	0.0016
6390	Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	ATP2A1	0.0016
364	Corticosteroid 11-beta-dehydrogenase isozyme 1	HSD11B1	0.0016
1243	Cathepsin D	CTSD	0.0016
3913	Glutamic acid decarboxylase	GAD65	0.0016
788	Creatine kinase M-type	CKM	0.0016
572	Integrin alpha-L	ITGAL	0.0016
6259	(3R)-hydroxymyristoyl-acyl carrier protein dehydratase	fabZ	0.0016
1123	Eosinophil cationic protein	RNASE3	0.0016
6100	BDNF/NT-3 growth factors receptor	NTRK2	0.0016
537	ATP synthase delta chain, mitochondrial	ATP5D	0.0015
3233	Bile acid receptor	NR1H4	0.0015
2334	Dethiobiotin synthetase	bioD	0.0015
6555	Dethiobiotin synthetase	bioD	0.0015
6124	Carbonic anhydrase 5B, mitochondrial	CA5B	0.0015
3611	Cytidine deaminase	cdd	0.0015
3707	Cytidine deaminase	cdd	0.0015
4211	Cytidine deaminase	CDA	0.0015
61	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase	folK	0.0015
2644	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase	folK	0.0015
2710	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase	folK	0.0015
559	NADH-ubiquinone oxidoreductase chain 1	MT-ND1	0.0015
828	Phenylalanine-4-hydroxylase	PAH	0.0015
3109	Phenylalanine-4-hydroxylase	phhA	0.0015
369	Coagulation factor VII	F7	0.0015
1291	cAMP response element-binding protein	CREB1	0.0015
3844	HLA class II histocompatibility antigen, DQ(6) alpha chain	HLA-DQA2	0.0015
139	Aldo-keto reductase family 1 member C1	AKR1C1	0.0015
453	S-adenosylmethionine synthetase isoform type-1	MAT1A	0.0015
1541	Metalloproteinase	mmp20	0.0014
201	Glutamate dehydrogenase 1, mitochondrial	GLUD1	0.0014
1039	Histone deacetylase 9	HDAC9	0.0014
6395	Myosin-14	MYH14	0.0014
2317	UDP-N-acetylmuramoylalanine--D-glutamate ligase	murD	0.0014
5818	Folate receptor alpha	FOLR1	0.0014
2129	Sucrase-isomaltase, intestinal	SI	0.0014
709	ATP-sensitive inward rectifier potassium channel 1	KCNJ1	0.0014
1262	Corticotropin-lipotropin	POMC	0.0014
837	Glutamate [NMDA] receptor subunit epsilon-1	GRIN2A	0.0014
6164	POU domain, class 5, transcription factor 1	POU5F1	0.0014
1422	Serine/threonine-protein kinase 6	AURKA	0.0014
277	Purine nucleoside phosphorylase	PNP	0.0014
2870	Purine nucleoside phosphorylase	punA	0.0014
2945	Purine nucleoside phosphorylase	punA	0.0014
4659	Purine nucleoside phosphorylase	TM_1596	0.0014
4825	Purine nucleoside phosphorylase	TTHA1435	0.0014
3904	Alanine aminotransferase 2	GPT2	0.0013
735	Alanine aminotransferase 1	GPT	0.0013
3379	Kinesin-like protein KIF11	KIF11	0.0013
6211	Tubulin epsilon chain	TUBE1	0.0013
6212	Tubulin gamma-1 chain	TUBG1	0.0013
6210	Tubulin delta chain	TUBD1	0.0013
3456	Heat shock protein HSP 90-beta	HSP90AB1	0.0013
1152	Glycogen phosphorylase, muscle form	PYGM	0.0013
561	Retinol-binding protein II, cellular	RBP2	0.0013
35	Dehydrogenase/reductase SDR family member 4	DHRS4	0.0013
4073	Retinol dehydrogenase 11	RDH11	0.0013
4074	Retinol dehydrogenase 14	RDH14	0.0013
1097	Lecithin retinol acyltransferase	LRAT	0.0013
589	Retinoid-binding protein 7	RBP7	0.0013
753	Retinol-binding protein III, cellular	RBP5	0.0013
4071	Short-chain dehydrogenase/reductase 3	DHRS3	0.0013
4075	Photoreceptor outer segment all-trans retinol dehydrogenase	RDH8	0.0013
863	Cellular retinaldehyde-binding protein	RLBP1	0.0013
800	Retinol dehydrogenase 12	RDH12	0.0013
282	Interphotoreceptor retinoid-binding protein	RBP3	0.0013
651	Retinol dehydrogenase 13	RDH13	0.0013
4072	All-trans-retinol 13,14-reductase	RETSAT	0.0013
245	Large neutral amino acids transporter small subunit 1	SLC7A5	0.0013
5577	N5-carboxyaminoimidazole ribonucleotide mutase	purE	0.0013
5598	Glycerol uptake operon antiterminator-related protein	TM_1436	0.0013
5591	Complement component C8 gamma chain	C8G	0.0013
3792	KHG/KDPG aldolase [Includes: 4-hydroxy-2-oxoglutarate aldolase	eda	0.0013
5582	Regulator of transcription; stringent starvation protein A	sspA	0.0013
2838	Ribose-5-phosphate isomerase A	rpiA	0.0013
2952	Ribose-5-phosphate isomerase A	rpiA	0.0013
5595	Ribose-5-phosphate isomerase A	rpiA	0.0013
4695	UPF0124 protein yfiH	yfiH	0.0013
5590	N utilization substance protein B homolog	nusB	0.0013
5588	Cell division protein FtsY	TM_0570	0.0013
4375	Glutamine synthetase 1	glnA1	0.0013
5587	Iron(III)-binding periplasmic protein	fbpA	0.0013
5583	RNA 3'-terminal phosphate cyclase	rtcA	0.0013
5586	Pleckstrin homology domain-containing family A member 1	PLEKHA1	0.0013
5593	Transferase	Not Available	0.0013
5581	Beta-fructosidase	bfrA	0.0013
5060	Intron-associated endonuclease 1	ITEVIR	0.0013
5575	Short tail fiber protein	12	0.0013
5600	Pyruvate decarboxylase	pdc	0.0013
5592	Ribonucleoside-diphosphate reductase subunit beta	nrdF	0.0013
5580	Hexon protein	PII	0.0013
5574	Invasin	YPTB1668	0.0013
199	Monocarboxylate transporter 8	SLC16A2	0.0013
3007	Carbonic anhydrase 12	CA12	0.0013
4205	Carbonic anhydrase 9	CA9	0.0013
891	Dihydropteroate synthase	folP	0.0013
5359	Dihydropteroate synthase	folP	0.0013
7175	Dihydropteroate synthase	sulI	0.0013
6933	Calcium-activated potassium channel subunit beta-4	KCNMB4	0.0012
6931	Calcium-activated potassium channel subunit beta-1	KCNMB1	0.0012
6932	Calcium-activated potassium channel subunit beta-3	KCNMB3	0.0012
6116	Gastric triacylglycerol lipase	LIPF	0.0012
6934	Small conductance calcium-activated potassium channel protein 1	KCNN1	0.0012
6935	Small conductance calcium-activated potassium channel protein 2	KCNN2	0.0012
6936	Small conductance calcium-activated potassium channel protein 3	KCNN3	0.0012
182	2-oxoglutarate dehydrogenase E1 component, mitochondrial	OGDH	0.0012
630	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial	ACADSB	0.0012
3806	cGMP-dependent 3',5'-cyclic phosphodiesterase	PDE2A	0.0012
3382	Glycolipid transfer protein	GLTP	0.0012
694	Matrix protein 2	M	0.0012
3823	Cytokine receptor common gamma chain	IL2RG	0.0012
85	Growth hormone receptor	GHR	0.0012
509	Thymidine kinase	TK	0.0012
570	Thymidine kinase	TK	0.0012
2559	Thymidine kinase	TK	0.0012
3430	Thymidine kinase	tdk	0.0012
3518	Thymidine kinase	TK	0.0012
5301	Thymidine kinase	tdk	0.0012
5771	Thymidine kinase	ORF36	0.0012
7009	Thymidine kinase	ORF36	0.0012
368	Enoyl-[acyl-carrier-protein] reductase [NADH]	inhA	0.0012
3228	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0012
3678	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0012
6856	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0012
338	DNA polymerase	UL30	0.0012
379	DNA polymerase	UL54	0.0012
697	DNA polymerase	ORF28	0.0012
2482	DNA polymerase	43	0.0012
4104	DNA polymerase	BALF5	0.0012
997	Protein kinase C beta type	PRKCB	0.0012
200	Carnitine O-palmitoyltransferase 2, mitochondrial	CPT2	0.0012
451	Carnitine O-palmitoyltransferase I, liver isoform	CPT1A	0.0012
1295	Fatty acid synthase	FASN	0.0012
4992	Cytochrome c peroxidase	Not Available	0.0012
331	Retinol-binding protein I, cellular	RBP1	0.0012
1360	Sphingomyelin phosphodiesterase	SMPD1	0.0011
627	11-cis retinol dehydrogenase	RDH5	0.0011
640	Aldehyde dehydrogenase 1A3	ALDH1A3	0.0011
707	72 kDa type IV collagenase	MMP2	0.0011
1970	Protein kinase C alpha type	PRKCA	0.0011
3087	Nicotinate-nucleotide adenylyltransferase	nadD	0.0011
4469	Nicotinate-nucleotide adenylyltransferase	nadD	0.0011
754	Pancreatic triacylglycerol lipase	PNLIP	0.0011
3085	Molybdopterin-guanine dinucleotide biosynthesis protein A	mobA	0.0011
4533	Glyoxalase family protein	BC_1747	0.0011
3132	Tryptophan synthase alpha chain	trpA	0.0011
6568	Tryptophan synthase alpha chain	trpA	0.0011
5328	Prostaglandin F synthase	Tb11.02.2310	0.0011
3729	Citrate synthase	gltA	0.0011
4575	Citrate synthase	cit	0.0011
4580	Citrate synthase	gltA	0.0011
5006	RNASE4 protein	RNASE4	0.0011
5599	3-carboxy-cis,cis-muconate cycloisomerase	pcaB	0.0011
355	GMP synthase [glutamine-hydrolyzing]	GMPS	0.0011
4353	GMP synthase [glutamine-hydrolyzing]	guaA	0.0011
2555	Pol polyprotein	pol	0.0011
3242	Pol polyprotein	gag-pol	0.0011
3471	Pol polyprotein	gag-pro-pol	0.0011
5256	Pol polyprotein	pol	0.0011
6469	Pol polyprotein	gag-pol	0.0011
6565	Pol polyprotein	Not Available	0.0011
5463	Calcium-activated potassium channel subunit beta 2	KCNMB2	0.0011
2300	Lysozyme	E	0.0011
3633	Lysozyme	R	0.0011
5597	Lysozyme	17	0.0011
6459	Glycodelin	PAEP	0.0011
773	Folylpolyglutamate synthase, mitochondrial	FPGS	0.0011
170	Succinate semialdehyde dehydrogenase, mitochondrial	ALDH5A1	0.0011
2178	Metabotropic glutamate receptor 5	GRM5	0.0011
724	Interleukin-2 receptor alpha chain	IL2RA	0.0011
717	Interleukin-2 receptor subunit beta	IL2RB	0.0011
1810	Protein S100-A1	S100A1	0.001
6097	Protein S100-A2	S100A2	0.001
4116	Dihydropteroate synthetase	Not Available	0.001
1467	Tumor necrosis factor ligand superfamily member 13B	TNFSF13B	0.001
2603	Beta-lactamase II	blm	0.001
3583	6-phosphogluconolactonase	pgl	0.001
2149	Angiogenin	ANG	0.001
2521	Cell division protein ftsZ	ftsZ	0.001
3301	Cell division protein ftsZ	ftsZ	0.001
1144	Hepatocyte growth factor receptor	MET	0.001
66	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II	HSD3B2	0.001
493	25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	CYP27B1	0.001
2287	Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase	ATIC	0.001
345	Plasma retinol-binding protein	RBP4	0.001
439	Glutamate [NMDA] receptor subunit epsilon-4	GRIN2D	0.001
4041	Microsomal glutathione S-transferase 2	MGST2	0.001
2869	1-deoxy-D-xylulose 5-phosphate reductoisomerase	dxr	0.001
2286	Isocitrate dehydrogenase [NADP]	icd	0.001
2302	Isocitrate dehydrogenase [NADP]	icd	0.001
2771	Isocitrate dehydrogenase [NADP]	icd	0.001
3486	Fumarate hydratase class II	fumC	0.001
2942	Sialidase	nanH	0.001
3546	Sialidase	nedA	0.001
65	Matrix metalloproteinase-9	Not Available	0.001
2268	Cholesterol oxidase	choB	0.0009
2822	Cholesterol oxidase	choA	0.0009
2805	Heparan sulfate glucosamine 3-O-sulfotransferase 3A1	HS3ST3A1	0.0009
857	Malate dehydrogenase, mitochondrial	MDH2	0.0009
1048	Protein S100-A13	S100A13	0.0009
401	Glutamate [NMDA] receptor subunit zeta-1	GRIN1	0.0009
2226	Protein S100-A12	S100A12	0.0009
332	Beta-lactamase	blaZ	0.0009
2478	Beta-lactamase	ampC	0.0009
2613	Beta-lactamase	ampC	0.0009
2635	Beta-lactamase	ampC	0.0009
2700	Beta-lactamase	penP	0.0009
5445	Beta-lactamase	blaB	0.0009
6019	Beta-lactamase	SHV-7	0.0009
6701	Beta-lactamase	cphA	0.0009
2936	Oxygen-insensitive NAD(P)H nitroreductase	nfnB	0.0009
5184	Oxygen-insensitive NAD(P)H nitroreductase	nfnB	0.0009
941	Betaine--homocysteine S-methyltransferase 1	BHMT	0.0009
2452	Tryptophanyl-tRNA synthetase	trpS	0.0009
2283	Steroid Delta-isomerase	ksi	0.0009
2920	Steroid Delta-isomerase	ksi	0.0009
2132	Protein S100-B	S100B	0.0009
382	Glutamate receptor, ionotropic kainate 1	GRIK1	0.0008
3404	Exotoxin A	eta	0.0008
5579	Carboxypeptidase B	CPB1	0.0008
22	30S ribosomal protein S4	rpsD	0.0008
6714	30S ribosomal protein S4	rpsD	0.0008
2325	Sulfotransferase family cytosolic 2B member 1	SULT2B1	0.0008
3384	Macrophage migration inhibitory factor	MIF	0.0008
3616	Fatty acid-binding protein, epidermal	FABP5	0.0008
3478	Glucose-1-phosphate thymidylyltransferase	rmlA	0.0008
4277	Glucose-1-phosphate thymidylyltransferase	rmlA	0.0008
5433	UPF0230 protein TM_1468	TM_1468	0.0008
5430	Hepatocyte nuclear factor 4-gamma	HNF4G	0.0008
5431	Lipid binding protein	Not Available	0.0008
1867	Major prion protein	PRNP	0.0008
2232	Interleukin-5	IL5	0.0008
1593	Mucin-2	MUC2	0.0008
4031	Glutathione S-transferase A1	GSTA1	0.0008
411	Glycine N-methyltransferase	GNMT	0.0008
1649	Small inducible cytokine A2	CCL2	0.0008
1025	Aquaporin-1	AQP1	0.0008
5766	NAD-dependent deacetylase sirtuin-5	SIRT5	0.0008
473	L-lactate dehydrogenase A chain	LDHA	0.0007
130	Prostacyclin synthase	PTGIS	0.0007
6103	Arylamine N-acetyltransferase 1	NAT1	0.0007
128	Adenine phosphoribosyltransferase	APRT	0.0007
591	Glutamate [NMDA] receptor subunit 3B	GRIN3B	0.0007
2207	Rhodopsin	RHO	0.0007
6218	Pannexin-1	PANX1	0.0007
6207	30S ribosomal protein S14	rpsN	0.0007
6209	30S ribosomal protein S19	rpsS	0.0007
6712	30S ribosomal protein S19	rpsS	0.0007
6726	30S ribosomal protein S19	rpsS	0.0007
283	SEC14-like protein 2	SEC14L2	0.0007
6151	Monocarboxylate transporter 10	SLC16A10	0.0007
645	Penicillin-binding protein 1A	mrcA	0.0007
5805	Penicillin-binding protein 1A	ponA	0.0007
6185	Penicillin-binding protein 1A	mrcA	0.0007
6799	Penicillin-binding protein 1A	pbpA	0.0007
2298	Cytochrome P450-cam	camC	0.0007
2290	ADP-ribosyl cyclase 2	BST1	0.0007
226	Gonadotropin-releasing hormone receptor	GNRHR	0.0007
125	DNA polymerase beta	POLB	0.0007
2211	Fatty acid-binding protein, heart	FABP3	0.0007
6677	Myelin P2 protein	PMP2	0.0006
3126	Poly [ADP-ribose] polymerase 1	PARP1	0.0006
1341	Histamine H3 receptor	HRH3	0.0005
3238	Multidrug resistance protein mexA	mexA	0.0005
3116	Bacterioferritin	bfr	0.0005
4906	Bacterioferritin	bfr	0.0005
4965	Bacterioferritin	bfr	0.0005
3173	Enolase	eno	0.0005
3709	Glycerol uptake facilitator protein	glpF	0.0005
3336	C4-dicarboxylate transport transcriptional regulatory protein dctD	dctD	0.0005
3393	TGF-beta receptor type-2	TGFBR2	0.0005
5489	Ribonucleoside-diphosphate reductase 1 subunit beta	nrdB	0.0005
2021	Thrombomodulin	THBD	0.0005
3221	Cytochrome c4	cc4	0.0005
2183	Fatty acid-binding protein, adipocyte	FABP4	0.0005
6002	Prostaglandin E2 receptor EP4 subtype	PTGER4	0.0005
3191	Histidinol dehydrogenase	hisD	0.0005
5878	Alpha-7 nicotinic cholinergic receptor subunit	CHRFAM7A	0.0004
505	Glutamate [NMDA] receptor subunit epsilon-3	GRIN2C	0.0004
4131	Prostaglandin E2 receptor, EP3 subtype	PTGER3	0.0004
406	Prostaglandin E2 receptor, EP2 subtype	PTGER2	0.0004
4692	A/G-specific adenine glycosylase	mutY	0.0004
6042	Prostaglandin reductase 2	PTGR2	0.0004
2802	Endoglucanase G	celCCG	0.0004
2391	Ferrochelatase	hemH	0.0004
6502	Ferrochelatase	DKFZp686P18130	0.0004
1591	Ferrochelatase, mitochondrial	FECH	0.0004
1792	Tissue-type plasminogen activator	PLAT	0.0004
2101	Glutathione-requiring prostaglandin D synthase	HPGDS	0.0003
6270	Group IIE secretory phospholipase A2	PLA2G2E	0.0003
6496	Cytochrome c oxidase subunit 8A, mitochondrial	COX8A	0.0003
6493	Cytochrome c oxidase subunit 6C	COX6C	0.0003
6495	Cytochrome c oxidase subunit 7C, mitochondrial	COX7C	0.0003
6499	Cytochrome c oxidase polypeptide 7A1, mitochondrial	COX7A1	0.0003
6494	Cytochrome c oxidase subunit 7B, mitochondrial	COX7B	0.0003
6491	Cytochrome c oxidase subunit 5A, mitochondrial	COX5A	0.0003
6498	Cytochrome c oxidase subunit 6B1	COX6B1	0.0003
6497	Cytochrome c oxidase subunit 6A2, mitochondrial	COX6A2	0.0003
6489	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	COX4I1	0.0003
5793	Cytochrome c oxidase subunit 2	MT-CO2	0.0003
6559	Cytochrome c oxidase subunit 2	ctaC	0.0003
6669	Cytochrome c oxidase subunit 2	ctaC	0.0003
6490	Cytochrome c oxidase subunit 3	MT-CO3	0.0003
371	Cytochrome c oxidase subunit 1	MT-CO1	0.0003
6558	Cytochrome c oxidase subunit 1	ctaD	0.0003
1313	Lactoylglutathione lyase	GLO1	0.0003
2540	Choloylglycine hydrolase	cbh	0.0003
1768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit	GNG2	0.0003
1268	Neuropeptide S receptor	NPSR1	0.0003
1571	G protein-activated inward rectifier potassium channel 1	KCNJ3	0.0003
1581	G protein-activated inward rectifier potassium channel 2	KCNJ6	0.0003
6501	Fatty acid-binding protein, liver	FABP1	0.0003
6073	Potassium channel subfamily K member 9	KCNK9	0.0003
6072	Potassium channel subfamily K member 3	KCNK3	0.0003
6500	Phospholipase A2	PLA2G1B	0.0002
6135	Sodium channel subunit beta-4	SCN4B	0.0002
6134	Sodium channel subunit beta-3	SCN3B	0.0002
6132	Sodium channel subunit beta-1	SCN1B	0.0002
6127	Carbonic anhydrase-related protein	CA8	0.0002
6128	Carbonic anhydrase-related protein 10	CA10	0.0002
6133	Sodium channel subunit beta-2	SCN2B	0.0002
6129	Carbonic anhydrase-related protein 11	CA11	0.0002
3803	Sodium channel protein type 3 subunit alpha	SCN3A	0.0002
6130	Carbonic anhydrase 13	CA13	0.0002
4936	Cytochrome c2 iso-2	Not Available	0.0001
4916	Cyanoglobin	glbN	0.0001
4994	Hemoglobin-like protein HbO	glbO	0.0001
4915	Cytochrome c-550	psbV	0.0001
4959	Cytochrome c-550	psbV	0.0001
5216	Cytochrome c-550	psbV	0.0001
4925	Cytochrome c-type protein SHP	shp	0.0001
4904	Cytochrome c family protein	GSU1996	0.0001
4943	Cytochrome c6	petJ	0.0001
4954	Soluble cytochrome b558	Not Available	0.0001
4934	Cytochrome c-551	nirM	0.0001
5218	Cytochrome c-551	nirM	0.0001
4905	Cytochrome c2	Not Available	0.0001
4939	Cytochrome c2	cycA	0.0001
4964	Cytochrome c2	cycA	0.0001
4979	Cytochrome c2	cycA	0.0001
6673	Cytochrome c2	cycA	0.0001
4910	Cytoglobin	CYGB	0.0001
4984	Neuroglobin	NGB	0.0001
4981	Iron-starvation protein PigA	pigA	0.0001
4909	CooA protein	cooA	0.0001
4998	Hemoglobin-like protein yjbI	yjbI	0.0001
4935	Cytochrome c-554	cycA1	0.0001
4947	Bacterial hemoglobin	vhb	0.0001
4975	Cytochrome c-556	RPA3973	0.0001
4942	Diheme cytochrome c napB	napB	0.0001
4931	Cytochrome P450 167A1	CYP167A1	0.0001
5000	HemO	hemO	0.0001
4972	P450cin	cinA	0.0001
4960	Putative cytochrome P450-family protein	SCO7417	0.0001
4971	Nonaheme cytochrome c	hmcA	0.0001
4989	Cytochrome c551 peroxidase	ccp	0.0001
5222	Cytochrome c551 peroxidase	ccpA	0.0001
4961	Hemophore HasA	hasA	0.0001
4976	Apocytochrome f	petA	0.0001
6407	Apocytochrome f	petA	0.0001
4907	Cytochrome c-L	moxG	0.0001
6865	Cytochrome c-L	moxG	0.0001
4993	Hydroxylamine oxidoreductase	hao1	0.0001
4764	Cytochrome P450 165C4	CYP165C4	0.0001
4926	Heme-based aerotactic transducer hemAT	hemAT	0.0001
644	Heme oxygenase 2	HMOX2	0.0001
4982	Heme oxygenase 2	pbsA2	0.0001
4952	Catalase/peroxidase	katA	0.0001
4970	Cytochrome c nitrite reductase catalytic subunit	nrfA	0.0001
4937	Cytochrome oxidase subunit II	rcoxA	0.0001
4903	Methyl-accepting chemotaxis protein	Tar4	0.0001
4999	Cytochrome P450 165B3	CYP165B3	0.0001
3093	Catalase HPII	katE	0.0001
4908	Heme-regulated cyclic AMP phosphodiesterase	dosP	0.0001
4922	Cytochrome c, putative	SO_4144	0.0001
4920	Peroxidase/catalase	katG	0.0001
4990	PpcA	ppcA	0.0001
4948	Cytochrome c-553	Not Available	0.0001
4923	Cytochrome c3	DvMF_2499	0.0001
4945	Cytochrome c3	Not Available	0.0001
4949	Cytochrome c3	DVU_3171	0.0001
4968	Cytochrome c3	cytc3	0.0001
4997	Cytochrome c3	SO_2727	0.0001
5219	Cytochrome c3	cyd	0.0001
2119	Cytochrome b5	CYB5A	0.0001
4902	Nine-heme cytochrome c	Ddes_2038	0.0001
3189	High-molecular-weight cytochrome c	hmcA	0.0001
4956	Quinohemoprotein alcohol dehydrogenase ADH IIB	qbdA	0.0001
3375	Acidic cytochrome c3	Not Available	0.0001
4988	Sulfite oxidase, mitochondrial	SUOX	0.0001
2915	Sensor protein fixL	fixL	0.0001
4944	Sensor protein fixL	fixL	0.0001
4813	Heme oxygenase	hmuO	0.0001
5769	Heme oxygenase	Not Available	0.0001
3570	Cytochrome P450 152A1	cypC	0.0001
4385	Cytochrome c'	Not Available	0.0001
4967	Cytochrome c'	cycA	0.0001
5038	Cytochrome c'	Not Available	0.0001
5223	Cytochrome c'	cycP	0.0001
4037	Hypothetical protein	GPX1	0.0001
4297	Hypothetical protein	SP_1951	0.0001
4521	Hypothetical protein	BC_2969	0.0001
4540	Hypothetical protein	TM_1070	0.0001
4555	Hypothetical protein	MT1739	0.0001
4569	Hypothetical protein	mshD	0.0001
4578	Hypothetical protein	PA3270	0.0001
4747	Hypothetical protein	PA3967	0.0001
5177	Hypothetical protein	TM_0096	0.0001
5194	Hypothetical protein	PA1204	0.0001
5240	Hypothetical protein	Rv2991	0.0001
5370	Hypothetical protein	TM_1158	0.0001
5710	Hypothetical protein	Tb927.5.1360	0.0001
4289	Cytochrome P450	TT_P0059	0.0001
6262	Cytochrome P450	staP	0.0001
2230	Catalase	CAT	0.0001
3249	Catalase	katA	0.0001
3625	Catalase	katA	0.0001
4539	Catalase	katA	0.0001
4941	Catalase	katB	0.0001
3670	Soluble cytochrome b562 precursor	cybC	0.0001
3411	Cytochrome P450 121	cyp121	0.0001
3291	Cytochrome c-552	cycA	0.0001
4927	Cytochrome c-552	nrfA	0.0001
4938	Cytochrome c-552	cycA	0.0001
4953	Cytochrome c-552	nrfA	0.0001
5217	Cytochrome c-552	cycM	0.0001
2617	Nitric oxide synthase oxygenase	nos	0.0001
2701	Nitric oxide synthase oxygenase	nos	0.0001
3102	Flavohemoprotein	hmp	0.0001
4969	Flavohemoprotein	hmp	0.0001
4386	Hemoglobin-like protein HbN	glbN	0.0001
3127	Nitrite reductase	nirS	0.0001
3284	Nitrite reductase	nirS	0.0001
2845	Bifunctional P-450:NADPH-P450 reductase	CYP102A1	0.0001
2972	6-deoxyerythronolide B hydroxylase	eryF	0.0001
358	Cystathionine beta-synthase	CBS	0
1507	Cytochrome c	CYCS	0
693	Hemoglobin subunit beta	HBB	0
6268	Hydroxyacid oxidase 1	HAO1	0
810	Heme oxygenase 1	HMOX1	0
3391	Heme oxygenase 1	pbsA1	0

(*) Categorization taken from DrugBank: therapeutic category or general category of a drug (i.e. anti-convulsant, antibacterial, etc.)

DB01254 - Dasatinib

Targets

Enzymes

Transporters

Predictions