DT-Web

DB01059 - Norfloxacin


Identification
Name Norfloxacin
Accession Number DB01059 (APRD00469)
Type small molecule
Description A synthetic fluoroquinolone (fluoroquinolones) with broad-spectrum antibacterial activity against most gram-negative and gram-positive bacteria. Norfloxacin inhibits bacterial DNA gyrase. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 319.3308
Groups approved
Monoisotopic Weight 319.133219662
Pharmacology
Indication For the treatment of urinary tract infection
Mechanism of action The bactericidal action of Norfloxacin results from inhibition of the enzymes topoisomerase II (DNA gyrase) and topoisomerase IV, which are required for bacterial DNA replication, transcription, repair, and recombination. Norfloxacin is a broad-spectrum antibiotic that is active against both gram-positive and gram-negative bacterias. The fluorine atom at the 6 position increases potency against gram-negative organisms, and the piperazine moiety at the 7 position is responsible for anti-pseudomonal activity
Absorption Rapid
Protein binding 10 and 15% (Serum protein binding)
Biotransformation Via liver and kidney
Route of elimination Norfloxacin is eliminated through metabolism, biliary excretion, and renal excretion. Renal excretion occurs by both glomerular filtration and tubular secretion as evidenced by the high rate of renal clearance (approximately 275 mL/min).
Toxicity Not Available
Affected organisms
  • Enteric bacteria and other eubacteria
Interactions
Drug Interactions
Drug Mechanism of interaction
Acenocoumarol The quinolone antibiotic, norfloxacin, may increase the anticoagulant effect of acenocoumarol.
Aluminium Formation of non-absorbable complexes
Aminophylline Norfloxacin may increase the effect of aminophylline.
Anisindione The quinolone antibiotic, norfloxacin, may increase the anticoagulant effect of anisindione.
Artemether Additive QTc-prolongation may occur. Concomitant therapy should be avoided.
Caffeine Norfloxacin may increase the effect and toxicity of caffeine.
Calcium Formation of non-absorbable complexes
Calcium Acetate Calcium salts such as calcium acetate may decrease the absorption of quinolone antibiotics such as norfloxacin. Of concern only with oral administration of both agents. Interactions can be minimized by administering oral quinolone at least 2 hours before, or 6 hours after, the dose of an oral calcium supplement. Monitor for decreased therapeutic effects of oral quinolones if administered with oral calcium supplements.
Clozapine Ciprofloxacin may increase clozapine serum levels
Cyclosporine Norfloxacin may increase the effect and toxicity of cyclosporine.
Dicumarol The quinolone antibiotic, norfloxacin, may increase the anticoagulant effect of dicumarol.
Dyphylline Norfloxacin may increase the effect of dyphylline.
Foscarnet Increased risk of convulsions
Iron Formation of non-absorbable complexes
Iron Dextran Formation of non-absorbable complexes
Lumefantrine Additive QTc-prolongation may occur. Concomitant therapy should be avoided.
Magnesium Formation of non-absorbable complexes
Magnesium oxide Formation of non-absorbable complexes
Oxtriphylline Norfloxacin may increase the effect of oxtriphylline.
Sucralfate Formation of non-absorbable complexes
Tacrine The metabolism of Tacrine, a CYP1A2 substrate, may be reduced by strong CYP1A2 inhibitors such as Norfloxacin. Consider modifying therapy to avoid Tacrine toxicity. Monitor the efficacy and toxicity of Tacrine if Norfloxacin is initiated, discontinued or if the dose is changed.
Tacrolimus Additive QTc-prolongation may occur increasing the risk of serious ventricular arrhythmias. Concomitant therapy should be used with caution.
Tamsulosin Norfloxacin, a CYP3A4 inhibitor, may decrease the metabolism and clearance of Tamsulosin, a CYP3A4 substrate. Monitor for changes in therapeutic/adverse effects of Tamsulosin if Norfloxacin is initiated, discontinued, or dose changed.
Theophylline Norfloxacin may increase the effect of theophylline.
Thiothixene May cause additive QTc-prolonging effects. Increased risk of ventricular arrhythmias. The strong CYP1A2 inhibitor, Norfloxacin, may also decrease the metabolism and clearance of Thiothixene, a CYP1A2 substrate. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of both agents if concomitant therapy is initiated, discontinued or dose changed. Thorough risk:benefit assessment is required prior to co-administration.
Tizanidine Norfloxacin may decrease the metabolism and clearance of Tizanidine. Consider alternate therapy or use caution during co-administration.
Tolterodine Norfloxacin may decrease the metabolism and clearance of Tolterodine. Adjust Tolterodine dose and monitor for efficacy and toxicity.
Toremifene Additive QTc-prolongation may occur, increasing the risk of serious ventricular arrhythmias. Consider alternate therapy. A thorough risk:benefit assessment is required prior to co-administration.
Tramadol Norfloxacin may increase Tramadol toxicity by decreasing Tramadol metabolism and clearance.
Trazodone The CYP3A4 inhibitor, Norfloxacin, may increase Trazodone efficacy/toxicity by decreasing Trazodone metabolism and clearance. Monitor for changes in Trazodone efficacy/toxicity if Norfloxacin is initiated, discontinued or dose changed.
Trimipramine Additive QTc-prolongation may occur, increasing the risk of serious ventricular arrhythmias. Concomitant therapy should be used with caution.
Voriconazole Additive QTc prolongation may occur. Consider alternate therapy or monitor for QTc prolongation as this can lead to Torsade de Pointes (TdP).
Vorinostat Additive QTc prolongation may occur. Consider alternate therapy or monitor for QTc prolongation as this can lead to Torsade de Pointes (TdP).
Warfarin The quinolone antibiotic, norfloxacin, may increase the anticoagulant effect of warfarin.
Zinc Formation of non-absorbable complexes
Ziprasidone Additive QTc-prolonging effects may increase the risk of severe arrhythmias. Concomitant therapy is contraindicated.
Zuclopenthixol Additive QTc prolongation may occur. Consider alternate therapy or use caution and monitor for QTc prolongation as this can lead to Torsade de Pointes (TdP).
Food Interactions
  • Avoid high doses of caffeine.
  • Take on an empty stomach. Drink liberally.

Targets


DNA topoisomerase 4 subunit A
Name DNA topoisomerase 4 subunit A
Gene Name parC
Pharmacological action yes
Actions inhibitor
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Rafii F, Park M, Novak JS: Alterations in DNA gyrase and topoisomerase IV in resistant mutants of Clostridium perfringens found after in vitro treatment with fluoroquinolones. Antimicrob Agents Chemother. 2005 Feb;49(2):488-92. - Pubmed
  • Vila J, Sanchez-Cespedes J, Sierra JM, Piqueras M, Nicolas E, Freixas J, Giralt E: Antibacterial evaluation of a collection of norfloxacin and ciprofloxacin derivatives against multiresistant bacteria. Int J Antimicrob Agents. 2006 Jul;28(1):19-24. Epub 2006 Jun 14. - Pubmed
  • Oyamada Y, Ito H, Fujimoto K, Asada R, Niga T, Okamoto R, Inoue M, Yamagishi J: Combination of known and unknown mechanisms confers high-level resistance to fluoroquinolones in Enterococcus faecium. J Med Microbiol. 2006 Jun;55(Pt 6):729-36. - Pubmed
  • Drlica K, Zhao X: DNA gyrase, topoisomerase IV, and the 4-quinolones. Microbiol Mol Biol Rev. 1997 Sep;61(3):377-92. - Pubmed
DTHybrid score 0.9341
DNA gyrase subunit A
Name DNA gyrase subunit A
Gene Name gyrA
Pharmacological action yes
Actions inhibitor
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Hombrouck C, Capmau ML, Moreau N: Overexpression, purification and photoaffinity labeling with a 3H-analogue of norfloxacin, of the GyrA and GyrB subunits of the DNA gyrase. Cell Mol Biol (Noisy-le-grand). 1999 May;45(3):347-52. - Pubmed
  • Hooper DC: Quinolone mode of action--new aspects. Drugs. 1993;45 Suppl 3:8-14. - Pubmed
  • Fukuda H, Hori S, Hiramatsu K: Antibacterial activity of gatifloxacin (AM-1155, CG5501, BMS-206584), a newly developed fluoroquinolone, against sequentially acquired quinolone-resistant mutants and the norA transformant of Staphylococcus aureus. Antimicrob Agents Chemother. 1998 Aug;42(8):1917-22. - Pubmed
  • Drlica K, Zhao X: DNA gyrase, topoisomerase IV, and the 4-quinolones. Microbiol Mol Biol Rev. 1997 Sep;61(3):377-92. - Pubmed
DTHybrid score 0.9762
DNA topoisomerase 2-alpha
Name DNA topoisomerase 2-alpha
Gene Name TOP2A
Pharmacological action unknown
Actions inhibitor
References
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score 0.7487

Enzymes


Cytochrome P450 1A2
Name Cytochrome P450 1A2
Gene Name CYP1A2
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.6133
Cytochrome P450 3A4
Name Cytochrome P450 3A4
Gene Name CYP3A4
Actions inhibitor
References
  • Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.6679
Cytochrome P450 3A5
Name Cytochrome P450 3A5
Gene Name CYP3A5
Actions inhibitor
References
  • Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.4111
Cytochrome P450 3A7
Name Cytochrome P450 3A7
Gene Name CYP3A7
Actions inhibitor
References
  • Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.3248
Cytochrome P450 1A1
Name Cytochrome P450 1A1
Gene Name CYP1A1
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.289
Cytochrome P450 2A6
Name Cytochrome P450 2A6
Gene Name CYP2A6
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.3175

Transporters


Organic cation/carnitine transporter 2
Name Organic cation/carnitine transporter 2
Gene Name SLC22A5
Actions inhibitor
References
  • Ohashi R, Tamai I, Yabuuchi H, Nezu JI, Oku A, Sai Y, Shimane M, Tsuji A: Na(+)-dependent carnitine transport by organic cation transporter (OCTN2): its pharmacological and toxicological relevance. J Pharmacol Exp Ther. 1999 Nov;291(2):778-84. - Pubmed
DTHybrid score 0.3192
Solute carrier family 22 member 6
Name Solute carrier family 22 member 6
Gene Name SLC22A6
Actions inhibitor
References
  • Jariyawat S, Sekine T, Takeda M, Apiwattanakul N, Kanai Y, Sophasan S, Endou H: The interaction and transport of beta-lactam antibiotics with the cloned rat renal organic anion transporter 1. J Pharmacol Exp Ther. 1999 Aug;290(2):672-7. - Pubmed
DTHybrid score 0.3672

Predictions


Id Partner name Gene Name Score
6224 DNA gyrase subunit A gyrA 0.9762
886 DNA topoisomerase 4 subunit A parC 0.9341
6226 DNA topoisomerase 4 subunit A parC 0.9341
1588 Multidrug resistance protein 1 ABCB1 0.3242
4119 Cytochrome P450 2D6 CYP2D6 0.3152
4757 Cytochrome P450 2C9 CYP2C9 0.2709
6016 Cytochrome P450 2C19 CYP2C19 0.2445
4924 Cytochrome P450 2C8 CYP2C8 0.1946
6013 Cytochrome P450 2E1 CYP2E1 0.1645
6030 Cytochrome P450 2B6 CYP2B6 0.1566
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.154
862 Multidrug resistance-associated protein 1 ABCC1 0.1241
833 Organic cation/carnitine transporter 1 SLC22A4 0.1047
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.1038
6144 Solute carrier family 22 member 2 SLC22A2 0.0993
6142 Solute carrier family 22 member 8 SLC22A8 0.0967
587 Serum albumin ALB 0.0934
20 Prostaglandin G/H synthase 1 PTGS1 0.0843
6145 Solute carrier family 22 member 1 SLC22A1 0.0771
1898 Cytochrome P450 1B1 CYP1B1 0.0678
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.065
1024 Solute carrier family 22 member 11 SLC22A11 0.0632
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0632
6106 Cytochrome P450 2C18 CYP2C18 0.0619
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0604
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.059
6143 Solute carrier family 22 member 7 SLC22A7 0.0571
492 Histamine H1 receptor HRH1 0.0559
290 Prostaglandin G/H synthase 2 PTGS2 0.0523
776 Bile salt export pump ABCB11 0.049
4192 DNA topoisomerase 2-beta TOP2B 0.0484
6147 Solute carrier family 22 member 3 SLC22A3 0.0481
3811 Cytochrome P450 19A1 CYP19A1 0.0479
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0442
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0422
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0418
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0412
871 Glucocorticoid receptor NR3C1 0.0372
318 Alpha-2A adrenergic receptor ADRA2A 0.0369
6031 Cytochrome P450 3A43 CYP3A43 0.0355
824 Sodium-dependent serotonin transporter SLC6A4 0.0354
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0338
136 Estrogen receptor ESR1 0.0337
831 D(2) dopamine receptor DRD2 0.0334
502 5-hydroxytryptamine 2A receptor HTR2A 0.0332
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.033
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0325
847 Mu-type opioid receptor OPRM1 0.0324
2164 Multidrug resistance-associated protein 4 ABCC4 0.0323
556 Alpha-1A adrenergic receptor ADRA1A 0.0322
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0317
766 Beta-2 adrenergic receptor ADRB2 0.0312
6137 Multidrug resistance-associated protein 6 ABCC6 0.0311
320 5-hydroxytryptamine 1A receptor HTR1A 0.0307
4180 DNA-(apurinic or apyrimidinic site) lyase APEX1 0.0305
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0304
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0298
468 Cytochrome P450 4A11 CYP4A11 0.0296
6148 Multidrug resistance-associated protein 7 ABCC10 0.0294
6014 Cytochrome P450 2A13 CYP2A13 0.029
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.029
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0289
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0282
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0281
723 Cytosolic phospholipase A2 PLA2G4A 0.0275
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0275
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0275
341 5-hydroxytryptamine 3 receptor HTR3A 0.0272
633 Penicillin-binding proteins 1A/1B pbpA 0.0272
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0267
590 5-hydroxytryptamine 2C receptor HTR2C 0.0265
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0259
36 Insulin receptor INSR 0.0258
3941 Amine oxidase [flavin-containing] A MAOA 0.0257
713 Sodium-dependent dopamine transporter SLC6A3 0.0256
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0248
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0241
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0238
629 Alpha-2B adrenergic receptor ADRA2B 0.0238
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0237
193 Beta-1 adrenergic receptor ADRB1 0.0235
1353 DNA topoisomerase 1 TOP1 0.0232
3552 DNA topoisomerase 1 topA 0.0232
23 D(1A) dopamine receptor DRD1 0.0232
632 Alpha-1B adrenergic receptor ADRA1B 0.023
638 D(3) dopamine receptor DRD3 0.0229
738 Monocarboxylate transporter 1 SLC16A1 0.0223
467 Delta-type opioid receptor OPRD1 0.022
378 Alpha-2C adrenergic receptor ADRA2C 0.022
885 5-hydroxytryptamine 1B receptor HTR1B 0.0219
260 Cytochrome P450 51 ERG11 0.0212
761 Cytochrome P450 51 ERG11 0.0212
3163 Cytochrome P450 51 cyp51 0.0212
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0211
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0211
737 Mineralocorticoid receptor NR3C2 0.0202
295 Carbonic anhydrase 1 CA1 0.02
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0197
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0195
696 Kappa-type opioid receptor OPRK1 0.0194
588 Chromodomain-helicase-DNA-binding protein 1 CHD1 0.0192
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0192
731 HIV-1 protease HIV-1 protease 0.0189
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0185
2539 Tubulin alpha-1 chain TUBA4A 0.0185
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0182
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0182
592 Carbonic anhydrase 4 CA4 0.0182
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0181
3939 Amine oxidase [flavin-containing] B MAOB 0.0181
614 Progesterone receptor PGR 0.0181
645 Penicillin-binding protein 1A mrcA 0.018
5805 Penicillin-binding protein 1A ponA 0.018
6185 Penicillin-binding protein 1A mrcA 0.018
6799 Penicillin-binding protein 1A pbpA 0.018
1757 Myeloperoxidase MPO 0.0179
725 5-hydroxytryptamine 1D receptor HTR1D 0.0179
232 Corticosteroid-binding globulin SERPINA6 0.0176
161 Tubulin beta chain TUBB 0.0173
312 Tubulin beta chain TUB2 0.0173
777 Tumor necrosis factor TNF 0.0172
465 Calmodulin CALM1 0.0168
357 Carbonic anhydrase 2 CA2 0.0165
789 Alpha-1D adrenergic receptor ADRA1D 0.0164
3947 Xanthine dehydrogenase/oxidase XDH 0.0163
6136 Multidrug resistance-associated protein 5 ABCC5 0.0163
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0162
380 Cytochrome P450 17A1 CYP17A1 0.0162
6182 Cytochrome P450 2J2 CYP2J2 0.0161
844 Epidermal growth factor receptor EGFR 0.0161
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.016
198 Sodium channel protein type 10 subunit alpha SCN10A 0.016
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0156
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0155
373 Transthyretin TTR 0.0154
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.015
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0148
432 D(4) dopamine receptor DRD4 0.0146
4148 Serine/threonine-protein kinase mTOR MTOR 0.0145
6012 Tryptophan 2,3-dioxygenase TDO2 0.0145
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0143
3932 Glutathione S-transferase A2 GSTA2 0.0143
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0139
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0139
6220 Aryl hydrocarbon receptor AHR 0.0139
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0138
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0138
1517 Beta-3 adrenergic receptor ADRB3 0.0137
3923 Cholinesterase BCHE 0.0137
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0137
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0136
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0135
6102 Arylamine N-acetyltransferase 2 NAT2 0.0134
869 Estrogen receptor beta ESR2 0.0134
4237 50S ribosomal protein L22 rplV 0.0133
338 DNA polymerase UL30 0.0128
379 DNA polymerase UL54 0.0128
697 DNA polymerase ORF28 0.0128
2482 DNA polymerase 43 0.0128
4104 DNA polymerase BALF5 0.0128
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0128
811 Translocator protein TSPO 0.0127
596 3-oxo-5-alpha-steroid 4-dehydrogenase 1 SRD5A1 0.0126
6141 Sodium/bile acid cotransporter SLC10A1 0.0126
818 50S ribosomal protein L10 rplJ 0.0126
756 Sex hormone-binding globulin SHBG 0.0126
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0124
4238 50S ribosomal protein L4 rplD 0.0124
5578 50S ribosomal protein L4 rplD 0.0124
6173 50S ribosomal protein L4 rplD 0.0124
6219 50S ribosomal protein L4 rplD 0.0124
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0124
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0123
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0123
613 Atrial natriuretic peptide receptor A NPR1 0.0122
308 30S ribosomal protein S12 rpsL 0.0122
6704 30S ribosomal protein S12 rpsL 0.0122
3639 Thymidine phosphorylase deoA 0.0122
3936 Thymidine phosphorylase TYMP 0.0122
1010 Cytochrome P450 51A1 CYP51A1 0.0122
605 Fumarate reductase flavoprotein subunit frdA 0.0121
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0121
3673 Fumarate reductase flavoprotein subunit fccA 0.0121
4912 Fumarate reductase flavoprotein subunit ifcA 0.0121
6549 Fumarate reductase flavoprotein subunit frdA 0.0121
1 Peptidoglycan synthetase ftsI ftsI 0.0121
4155 Peptidoglycan synthetase ftsI ftsI 0.0121
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0121
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0121
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.012
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.012
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.012
16 Adenosine A1 receptor ADORA1 0.012
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0119
6020 Aldehyde oxidase AOX1 0.0119
4120 NADPH--cytochrome P450 reductase POR 0.0118
48 Pyridoxal kinase PDXK 0.0116
275 Arachidonate 5-lipoxygenase ALOX5 0.0115
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0115
642 3-oxo-5-alpha-steroid 4-dehydrogenase 2 SRD5A2 0.0115
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0114
716 5-hydroxytryptamine 7 receptor HTR7 0.0114
2499 Tubulin beta-2C chain TUBB2C 0.0113
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0112
474 Acetylcholinesterase ACHE 0.0112
705 Glutamate receptor 1 GRIA1 0.0111
1244 Low-density lipoprotein receptor-related protein 2 LRP2 0.0111
146 Androgen receptor AR 0.0111
131 Synaptic vesicular amine transporter SLC18A2 0.0111
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.011
4790 Glycosyltransferase GtfA gtfA 0.011
4604 Liver carboxylesterase 1 CES1 0.011
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.011
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0109
1636 Trace amine-associated receptor 1 TAAR1 0.0109
2449 Tubulin alpha-3 chain TUBA1A 0.0107
982 Cocaine- and amphetamine-regulated transcript protein CARTPT 0.0107
504 Mast/stem cell growth factor receptor KIT 0.0106
1178 Adenosine A2a receptor ADORA2A 0.0106
543 Penicillin-binding protein 1B mrcB 0.0104
6186 Penicillin-binding protein 1B ponB 0.0104
6822 Penicillin-binding protein 1b pbp1b 0.0104
6844 Penicillin-binding protein 1b pbp1b 0.0104
6126 Carbonic anhydrase 7 CA7 0.0104
228 Beta platelet-derived growth factor receptor PDGFRB 0.0101
94 5-hydroxytryptamine 4 receptor HTR4 0.01
124 Histamine H2 receptor HRH2 0.01
140 30S ribosomal protein S9 rpsI 0.01
6719 30S ribosomal protein S9 rpsI 0.01
6725 30S ribosomal protein S9 rpsI 0.01
115 Penicillin-binding protein 2 mrdA 0.0099
6069 Penicillin-binding protein 2 mrdA 0.0099
6118 Penicillin-binding protein 2 penA 0.0099
6187 Penicillin-binding protein 2 pbpA 0.0099
6686 Penicillin-binding protein 2 pbp2 0.0099
6939 Penicillin-binding protein 2 mrdA 0.0099
7163 Penicillin-binding protein 2 pbpA 0.0099
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0098
958 Insulin-like growth factor 1 receptor IGF1R 0.0097
6339 Ig kappa chain V-II region RPMI 6410 Not Available 0.0097
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0096
6043 Putative G-protein coupled receptor 44 GPR44 0.0094
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0094
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0093
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0093
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0093
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0093
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0093
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0093
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0093
992 Protein tyrosine kinase 2 beta PTK2B 0.0093
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0093
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0093
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0093
5849 cAMP-dependent protein kinase type I-alpha regulatory subunit PRKAR1A 0.0092
332 Beta-lactamase blaZ 0.0092
2478 Beta-lactamase ampC 0.0092
2613 Beta-lactamase ampC 0.0092
2635 Beta-lactamase ampC 0.0092
2700 Beta-lactamase penP 0.0092
5445 Beta-lactamase blaB 0.0092
6019 Beta-lactamase SHV-7 0.0092
6701 Beta-lactamase cphA 0.0092
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0091
26 Vascular endothelial growth factor receptor 3 FLT4 0.0091
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0091
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.009
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.009
68 Cannabinoid receptor 1 CNR1 0.009
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0089
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0089
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0089
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0089
6010 Thiamine transporter 1 SLC19A2 0.0089
1256 5-hydroxytryptamine 6 receptor HTR6 0.0089
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0088
3917 Methylenetetrahydrofolate reductase MTHFR 0.0088
33 Cystine/glutamate transporter SLC7A11 0.0087
32 Vascular endothelial growth factor receptor 1 FLT1 0.0087
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0087
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0087
1192 Sulfotransferase 1A1 SULT1A1 0.0086
558 Solute carrier family 12 member 1 SLC12A1 0.0086
163 D(1B) dopamine receptor DRD5 0.0086
407 Vascular endothelial growth factor receptor 2 KDR 0.0086
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0086
29 Tubulin beta-1 chain TUBB1 0.0086
122 P2Y purinoceptor 12 P2RY12 0.0086
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0086
4203 Histamine N-methyltransferase HNMT 0.0086
84 Nuclear receptor 0B1 NR0B1 0.0085
273 Apoptosis regulator Bcl-2 BCL2 0.0084
790 DNA polymerase subunit alpha B POLA2 0.0084
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0083
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0083
768 FK506-binding protein 1A FKBP1A 0.0083
2016 Dipeptidase 1 DPEP1 0.0082
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0082
22 30S ribosomal protein S4 rpsD 0.0081
6714 30S ribosomal protein S4 rpsD 0.0081
175 Thiamin pyrophosphokinase 1 TPK1 0.008
1050 Bile salt sulfotransferase SULT2A1 0.008
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.008
427 Substance-P receptor TACR1 0.0079
482 Glycine receptor subunit alpha-1 GLRA1 0.0079
528 5-hydroxytryptamine 1E receptor HTR1E 0.0078
976 Platelet glycoprotein IX GP9 0.0078
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0078
814 Ryanodine receptor 1 RYR1 0.0078
624 Guanidinoacetate N-methyltransferase GAMT 0.0078
571 Melatonin receptor type 1A MTNR1A 0.0078
362 Melatonin receptor type 1B MTNR1B 0.0078
2320 Thymidine kinase, cytosolic TK1 0.0077
1714 Mitogen-activated protein kinase 3 MAPK3 0.0076
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0075
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0075
4122 Histone deacetylase 2 HDAC2 0.0075
4228 Keratin, type II cytoskeletal 7 KRT7 0.0074
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0073
5626 Nucleoside diphosphate kinase B NME2 0.0073
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0072
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.007
7 Nitric oxide synthase, inducible NOS2 0.007
251 Alcohol dehydrogenase 1A ADH1A 0.007
284 DNA-directed RNA polymerase beta chain rpoB 0.007
5773 DNA-directed RNA polymerase beta chain rpoB 0.007
1656 CYP2B protein CYP2B 0.007
436 5-hydroxytryptamine 2B receptor HTR2B 0.0069
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.0069
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0068
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0068
469 Annexin A1 ANXA1 0.0067
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0067
239 Coagulation factor X F10 0.0067
2230 Catalase CAT 0.0066
3249 Catalase katA 0.0066
3625 Catalase katA 0.0066
4539 Catalase katA 0.0066
4941 Catalase katB 0.0066
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0066
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0065
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0065
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0065
904 Glutathione S-transferase P GSTP1 0.0065
106 Cannabinoid receptor 2 CNR2 0.0064
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0064
1820 Beta-nerve growth factor NGF 0.0064
952 Dipeptidyl peptidase 4 DPP4 0.0063
192 Creatine kinase, ubiquitous mitochondrial CKMT1A 0.0063
456 Creatine kinase, sarcomeric mitochondrial CKMT2 0.0063
92 Creatine kinase B-type CKB 0.0063
414 Sodium- and chloride-dependent creatine transporter 1 SLC6A8 0.0063
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0063
1196 Complement decay-accelerating factor CD55 0.0063
908 Glutathione S-transferase theta-1 GSTT1 0.0063
24 Thymidylate synthase TMP1 0.0063
359 Thymidylate synthase TYMS 0.0063
2626 Thymidylate synthase thyA 0.0063
2729 Thymidylate synthase thyA 0.0063
5352 Thymidylate synthase THYA 0.0063
444 Alcohol dehydrogenase 1B ADH1B 0.0062
6105 3-oxo-5-beta-steroid 4-dehydrogenase AKR1D1 0.0062
4311 tRNA TRDMT1 0.0062
4325 tRNA trmD 0.0062
4328 tRNA trmD 0.0062
537 ATP synthase delta chain, mitochondrial ATP5D 0.0061
4773 Deoxycytidine kinase DCK 0.0061
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0061
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0061
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0061
3426 Glutamine synthetase glnA 0.0061
3987 Glutamine synthetase GLUL 0.0061
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0061
6164 POU domain, class 5, transcription factor 1 POU5F1 0.006
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.006
208 DNA-directed RNA polymerase beta' chain rpoC 0.006
5774 DNA-directed RNA polymerase beta' chain rpoC 0.006
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.006
921 Glutamate receptor 2 GRIA2 0.006
569 Retinal dehydrogenase 2 ALDH1A2 0.0059
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0059
820 Glycine receptor subunit alpha-2 GLRA2 0.0059
511 5-hydroxytryptamine 1F receptor HTR1F 0.0059
6168 Solute carrier family 22 member 16 SLC22A16 0.0059
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0059
780 Retinoic acid receptor RXR-gamma RXRG 0.0059
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0059
5294 Nucleoside diphosphate kinase A NME1 0.0058
5934 Cytochrome P450 26A1 CYP26A1 0.0058
6067 Penicillin binding protein 2a mecA 0.0058
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0058
6766 O-GlcNAcase BT_4395 BT_4395 0.0058
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0057
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0057
6131 Carbonic anhydrase 14 CA14 0.0057
788 Creatine kinase M-type CKM 0.0057
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0057
165 FL cytokine receptor FLT3 0.0057
164 Histamine H4 receptor HRH4 0.0056
611 Retinal dehydrogenase 1 ALDH1A1 0.0056
823 Fibroblast growth factor receptor 2 FGFR2 0.0056
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0056
70 Type-1 angiotensin II receptor AGTR1 0.0055
2808 Chloramphenicol acetyltransferase 3 cat3 0.0055
719 Retinoic acid receptor responder protein 1 RARRES1 0.0055
770 Retinoic acid-induced protein 3 GPRC5A 0.0055
466 Solute carrier family 12 member 3 SLC12A3 0.0055
6149 Solute carrier family 22 member 10 SLC22A10 0.0055
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0054
153 Dopamine beta-hydroxylase DBH 0.0054
2112 Toll-like receptor 9 TLR9 0.0054
517 Alcohol dehydrogenase 1C ADH1C 0.0054
1852 Microtubule-associated protein 2 MAP2 0.0054
1039 Histone deacetylase 9 HDAC9 0.0054
828 Phenylalanine-4-hydroxylase PAH 0.0054
3109 Phenylalanine-4-hydroxylase phhA 0.0054
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0053
6122 Carbonic anhydrase 3 CA3 0.0053
88 Retinoic acid receptor RXR-beta RXRB 0.0053
6174 50S ribosomal protein L32 rpmF 0.0053
54 Prothrombin F2 0.0053
5998 Toll-like receptor 8 TLR8 0.0053
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0053
565 Extracellular calcium-sensing receptor CASR 0.0052
712 Tubulin alpha chain TUB1 0.0052
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0052
860 Nicotinamide N-methyltransferase NNMT 0.0051
583 Nicotinate-nucleotide pyrophosphorylase [carboxylating] QPRT 0.0051
2442 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0051
2459 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0051
699 Nicotinic acid receptor 1 GPR109A 0.0051
928 Nicotinic acid receptor 2 GPR109B 0.0051
438 Taste receptor type 1 member 2 TAS1R2 0.0051
891 Dihydropteroate synthase folP 0.0051
5359 Dihydropteroate synthase folP 0.0051
7175 Dihydropteroate synthase sulI 0.0051
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0051
6228 Nuclear receptor coactivator 1 NCOA1 0.0051
253 Sodium/potassium-transporting ATPase gamma chain FXYD2 0.0051
6044 Serum paraoxonase/lactonase 3 PON3 0.0051
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0051
2417 Chloramphenicol acetyltransferase cat 0.005
3278 Chloramphenicol acetyltransferase cat 0.005
6241 Nuclear receptor coactivator 2 NCOA2 0.005
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.005
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0049
2810 Dr hemagglutinin structural subunit draA 0.0049
518 Peroxidase/catalase T katG 0.0049
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0049
6432 Transporter snf 0.0049
856 Vitamin D3 receptor VDR 0.0049
277 Purine nucleoside phosphorylase PNP 0.0049
2870 Purine nucleoside phosphorylase punA 0.0049
2945 Purine nucleoside phosphorylase punA 0.0049
4659 Purine nucleoside phosphorylase TM_1596 0.0049
4825 Purine nucleoside phosphorylase TTHA1435 0.0049
3810 Catechol O-methyltransferase COMT 0.0048
1483 Membrane copper amine oxidase AOC3 0.0048
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0048
5923 Microtubule-associated protein tau MAPT 0.0048
5924 Microtubule-associated protein 4 MAP4 0.0048
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0047
3809 Estrogen-related receptor gamma ESRRG 0.0047
291 Nitric-oxide synthase, endothelial NOS3 0.0047
2236 Casein kinase II subunit alpha CSNK2A1 0.0047
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0047
2472 Voltage-gated potassium channel kcsA 0.0046
6366 Voltage-gated potassium channel kcsA 0.0046
563 Thyroid peroxidase TPO 0.0046
1629 Transcription factor AP-1 JUN 0.0046
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0046
173 Toll-like receptor 7 TLR7 0.0046
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0046
3686 Acyl-CoA thioesterase I precursor tesA 0.0045
3007 Carbonic anhydrase 12 CA12 0.0045
4205 Carbonic anhydrase 9 CA9 0.0045
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0044
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0044
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0044
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0044
400 Coagulation factor IX F9 0.0044
5461 Coagulation factor IX F9 0.0044
751 Potassium channel subfamily K member 6 KCNK6 0.0044
1275 Estrogen sulfotransferase SULT1E1 0.0044
6146 High affinity copper uptake protein 1 SLC31A1 0.0044
162 Retinoic acid receptor gamma-1 RARG 0.0043
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0043
461 Glycine receptor subunit alpha-3 GLRA3 0.0043
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0043
5698 Riboflavin synthase alpha chain ribE 0.0043
183 Vascular endothelial growth factor A VEGFA 0.0043
714 Glutathione reductase, mitochondrial GSR 0.0042
1176 Mitogen-activated protein kinase 1 MAPK1 0.0041
887 DNA gyrase subunit B gyrB 0.0041
4150 DNA gyrase subunit B gyrB 0.0041
6225 DNA gyrase subunit B gyrB 0.0041
408 Riboflavin kinase RFK 0.0041
244 Angiotensin-converting enzyme ACE 0.0041
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0041
3997 Cytochrome P450 24A1, mitochondrial CYP24A1 0.0041
4081 Vitamin K epoxide reductase complex subunit 1-like protein 1 VKORC1L1 0.0041
604 Vitamin K-dependent protein Z PROZ 0.0041
172 Potassium channel subfamily K member 1 KCNK1 0.004
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.004
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.004
1558 Transient receptor potential cation channel subfamily V member 1 TRPV1 0.004
1341 Histamine H3 receptor HRH3 0.0039
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0039
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0039
2268 Cholesterol oxidase choB 0.0039
2822 Cholesterol oxidase choA 0.0039
4146 Phosphatidylinositol 3-kinase regulatory subunit gamma PIK3R3 0.0039
4145 Phosphatidylinositol 3-kinase regulatory subunit beta PIK3R2 0.0039
1129 C-C chemokine receptor type 5 CCR5 0.0039
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0038
4164 Potassium voltage-gated channel subfamily KQT member 5 KCNQ5 0.0038
2298 Cytochrome P450-cam camC 0.0038
4163 Potassium voltage-gated channel subfamily KQT member 4 KCNQ4 0.0038
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0038
1063 Signal transducer and activator of transcription 5B STAT5B 0.0038
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0037
1525 Heparin-binding growth factor 2 FGF2 0.0037
5353 Glutamate decarboxylase alpha gadA 0.0037
1064 DNA (cytosine-5)-methyltransferase 1 DNMT1 0.0037
4217 Telomerase reverse transcriptase TERT 0.0037
634 Squalene monooxygenase SQLE 0.0037
7196 Squalene monooxygenase ERG1 0.0037
422 Vitamin K-dependent protein C PROC 0.0037
1245 Vitamin K-dependent protein S PROS1 0.0037
2283 Steroid Delta-isomerase ksi 0.0037
2920 Steroid Delta-isomerase ksi 0.0037
6167 Organic solute transporter subunit beta OSTB 0.0037
6166 Organic solute transporter subunit alpha OSTA 0.0037
822 Aldose reductase AKR1B1 0.0036
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0036
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0036
1867 Major prion protein PRNP 0.0036
5126 Arginase rocF 0.0036
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0035
1360 Sphingomyelin phosphodiesterase SMPD1 0.0035
1650 Heme carrier protein 1 SLC46A1 0.0035
5300 Antigen peptide transporter 1 TAP1 0.0035
185 Vasopressin V1a receptor AVPR1A 0.0035
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0035
117 Sterol O-acyltransferase 1 SOAT1 0.0035
889 3-oxoacyl-[acyl-carrier-protein] synthase 1 fabB 0.0035
6860 3-oxoacyl-[acyl-carrier-protein] synthase 1 kasA 0.0035
1025 Aquaporin-1 AQP1 0.0035
939 50S ribosomal protein L3 rplC 0.0035
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0035
322 Vasopressin V2 receptor AVPR2 0.0034
3957 Adenosine deaminase ADA 0.0034
2325 Sulfotransferase family cytosolic 2B member 1 SULT2B1 0.0034
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0034
581 Cytochrome P450 2R1 CYP2R1 0.0034
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0034
936 Ephrin type-A receptor 2 EPHA2 0.0034
459 Retinoic acid receptor RXR-alpha RXRA 0.0033
65 Matrix metalloproteinase-9 Not Available 0.0033
1618 High affinity nerve growth factor receptor NTRK1 0.0033
1281 Phosphatidylinositol 3-kinase regulatory subunit alpha PIK3R1 0.0033
3937 Fatty-acid amide hydrolase FAAH 0.0033
267 Plasminogen activator inhibitor 1 SERPINE1 0.0033
6085 Fatty acid-binding protein, intestinal FABP2 0.0033
3601 Dihydropteroate synthase 1 folP1 0.0033
3807 Dihydropteroate synthase 1 folP1 0.0033
3808 Dihydropteroate synthase 2 folP2 0.0033
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0033
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0033
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0033
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0033
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0033
448 Vitamin K-dependent gamma-carboxylase GGCX 0.0033
499 Arginine decarboxylase ADC 0.0033
130 Prostacyclin synthase PTGIS 0.0033
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0032
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0032
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0032
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0032
109 Mitochondrial carnitine/acylcarnitine carrier protein CACL SLC25A29 0.0032
636 Mitochondrial carnitine/acylcarnitine carrier protein SLC25A20 0.0032
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0032
1770 Phospholipase C PLCL1 0.0032
2841 Phospholipase C plc 0.0032
500 Monocarboxylate transporter 4 SLC16A3 0.0032
2461 D-alanyl-D-alanine carboxypeptidase Not Available 0.0032
5756 D-alanyl-D-alanine carboxypeptidase dac 0.0032
3086 Plasmepsin-2 Not Available 0.0032
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0032
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0032
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0031
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0031
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0031
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0031
6207 30S ribosomal protein S14 rpsN 0.0031
6209 30S ribosomal protein S19 rpsS 0.0031
6712 30S ribosomal protein S19 rpsS 0.0031
6726 30S ribosomal protein S19 rpsS 0.0031
3913 Glutamic acid decarboxylase GAD65 0.0031
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0031
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0031
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0031
342 P protein [Includes: DNA-directed DNA polymerase P 0.0031
612 P protein [Includes: DNA-directed DNA polymerase P 0.0031
577 Argininosuccinate lyase ASL 0.0031
484 Tyrosine-protein kinase ABL2 ABL2 0.0031
834 Arginase-2, mitochondrial ARG2 0.0031
2578 Tubulin beta-3 chain TUBB3 0.003
2285 Streptogramin A acetyltransferase vatD 0.003
798 Osteocalcin BGLAP 0.003
150 Cationic amino acid transporter 3 SLC7A3 0.003
235 High-affinity cationic amino acid transporter 1 SLC7A1 0.003
58 Cationic amino acid transporter 4 SLC7A4 0.003
319 Opioid receptor, sigma 1 OPRS1 0.003
6221 Steroid hormone receptor ERR1 ESRRA 0.0029
654 Flavin reductase BLVRB 0.0029
6218 Pannexin-1 PANX1 0.0029
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0029
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0029
1569 G1/S-specific cyclin-D1 CCND1 0.0029
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0029
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0029
512 DNA-directed RNA polymerase alpha chain rpoA 0.0029
5772 DNA-directed RNA polymerase alpha chain rpoA 0.0029
3688 Branched-chain-amino-acid aminotransferase ilvE 0.0028
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0028
1374 Natriuretic peptides B NPPB 0.0028
1630 Integrin beta-2 ITGB2 0.0028
1827 Gap junction alpha-1 protein GJA1 0.0028
1908 Vascular cell adhesion protein 1 VCAM1 0.0028
4252 Penicillin-binding protein 5 dacA 0.0028
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0028
159 Penicillin-binding protein 2B penA 0.0028
6121 Penicillin-binding protein 2B penA 0.0028
4103 Proteasome subunit beta type 2 PSMB2 0.0028
4102 Proteasome subunit beta type 5 PSMB5 0.0028
4101 Proteasome subunit beta type 1 PSMB1 0.0028
740 Argininosuccinate synthase ASS1 0.0028
865 Argininosuccinate synthase ASS1 0.0028
2680 Argininosuccinate synthase argG 0.0028
3194 Argininosuccinate synthase argG 0.0028
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0027
369 Coagulation factor VII F7 0.0027
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0027
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0027
4173 Tyrosine-protein kinase JAK2 JAK2 0.0027
4226 Uridine phosphorylase 2 UPP2 0.0027
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0027
3849 Insulin-like growth factor-binding protein 7 IGFBP7 0.0027
2009 Protein NOV homolog NOV 0.0027
3847 Neuroendocrine convertase 2 PCSK2 0.0027
1949 Carboxypeptidase E CPE 0.0027
3850 Synaptotagmin-like protein 4 SYTL4 0.0027
3848 Neuroendocrine convertase 1 PCSK1 0.0027
3846 Retinoblastoma-associated protein RB1 0.0027
3830 Calreticulin CALR 0.0027
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0027
412 Peroxisomal carnitine O-octanoyltransferase CROT 0.0027
3685 Catabolite gene activator crp 0.0027
551 Carnitine O-acetyltransferase CRAT 0.0027
4655 Adenylate cyclase cyaC 0.0027
4759 Adenylate cyclase cyaB2 0.0027
3904 Alanine aminotransferase 2 GPT2 0.0026
735 Alanine aminotransferase 1 GPT 0.0026
1864 RET proto-oncogene RET 0.0026
1648 Elastin ELN 0.0026
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0026
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0026
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0026
293 Gamma-glutamyl hydrolase GGH 0.0026
49 Endothelin B receptor EDNRB 0.0026
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0026
509 Thymidine kinase TK 0.0025
570 Thymidine kinase TK 0.0025
2559 Thymidine kinase TK 0.0025
3430 Thymidine kinase tdk 0.0025
3518 Thymidine kinase TK 0.0025
5301 Thymidine kinase tdk 0.0025
5771 Thymidine kinase ORF36 0.0025
7009 Thymidine kinase ORF36 0.0025
5880 Thrombopoietin receptor MPL 0.0025
6034 Hydroxyindole O-methyltransferase ASMT 0.0025
6035 Nuclear receptor ROR-beta RORB 0.0025
6036 Eosinophil peroxidase EPX 0.0025
390 Adenosine A3 receptor ADORA3 0.0025
707 72 kDa type IV collagenase MMP2 0.0025
365 Dihydrofolate reductase DHFR 0.0025
2381 Dihydrofolate reductase DFR1 0.0025
2833 Dihydrofolate reductase Not Available 0.0025
2931 Dihydrofolate reductase folA 0.0025
3544 Dihydrofolate reductase folA 0.0025
3682 Dihydrofolate reductase folA 0.0025
6642 Dihydrofolate reductase folA 0.0025
6756 Dihydrofolate reductase dfrA 0.0025
174 Sigma 1-type opioid receptor SIGMAR1 0.0025
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0024
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0024
4225 Uridine phosphorylase 1 UPP1 0.0024
578 Endothelin-1 receptor EDNRA 0.0024
544 Potassium voltage-gated channel subfamily E member 1 KCNE1 0.0024
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0024
6039 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A PDE11A 0.0024
6048 Troponin C, skeletal muscle TNNC2 0.0024
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0024
471 Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) SLC6A14 0.0024
268 Adenosine A2b receptor ADORA2B 0.0024
6070 Nischarin NISCH 0.0024
5852 Type-2 angiotensin II receptor AGTR2 0.0024
3856 Fibroblast growth factor receptor 3 FGFR3 0.0024
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0023
550 Amiloride-sensitive sodium channel subunit delta SCNN1D 0.0023
27 Amiloride-sensitive sodium channel subunit beta SCNN1B 0.0023
552 Amiloride-sensitive sodium channel subunit gamma SCNN1G 0.0023
213 Amiloride-sensitive sodium channel subunit alpha SCNN1A 0.0023
1830 5'-nucleotidase NT5E 0.0023
2249 Aspartate aminotransferase aspC 0.0023
2671 Aspartate aminotransferase aspC 0.0023
5490 Aspartate aminotransferase Not Available 0.0023
2981 Phospholipase A2, membrane associated PLA2G2A 0.0023
413 Amidophosphoribosyltransferase PPAT 0.0023
2515 Amidophosphoribosyltransferase purF 0.0023
3714 Amidophosphoribosyltransferase purF 0.0023
4760 Mll3241 protein mll3241 0.0023
1992 Vitamin D-binding protein GC 0.0022
997 Protein kinase C beta type PRKCB 0.0022
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0022
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0022
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0022
896 Glutathione S-transferase Mu 1 GSTM1 0.0022
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0022
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0022
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0022
765 Indoleamine 2,3-dioxygenase IDO1 0.0022
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0022
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0022
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0022
2155 Insulin-degrading enzyme IDE 0.0022
298 Renin REN 0.0021
6506 Stathmin-4 STMN4 0.0021
6033 High affinity interleukin-8 receptor A CXCR1 0.0021
2091 Endoplasmin HSP90B1 0.0021
718 Folate receptor gamma FOLR3 0.0021
299 Folate receptor beta FOLR2 0.0021
804 Mitochondrial folate transporter/carrier SLC25A32 0.0021
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0021
572 Integrin alpha-L ITGAL 0.0021
1198 Serum paraoxonase/arylesterase 1 PON1 0.0021
6223 Penicillin-binding protein 1C pbpC 0.0021
527 Prostacyclin receptor PTGIR 0.0021
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.0021
1970 Protein kinase C alpha type PRKCA 0.0021
2300 Lysozyme E 0.0021
3633 Lysozyme R 0.0021
5597 Lysozyme 17 0.0021
672 Prostaglandin F2-alpha receptor PTGFR 0.002
5682 Ribonuclease pancreatic RNASE1 0.002
2408 Tyrosine-protein kinase SYK SYK 0.002
3929 Phosphoethanolamine/phosphocholine phosphatase PHOSPHO1 0.002
549 Choline-phosphate cytidylyltransferase B PCYT1B 0.002
769 High-affinity choline transporter 1 SLC5A7 0.002
3933 Choline/ethanolaminephosphotransferase CEPT1 0.002
861 Choline kinase alpha CHKA 0.002
700 Choline dehydrogenase, mitochondrial CHDH 0.002
3927 Choline transporter-like protein 3 SLC44A3 0.002
1686 Choline transporter-like protein 1 SLC44A1 0.002
264 Choline/ethanolamine kinase [Includes: Choline kinase beta CHKB 0.002
3926 Choline transporter-like protein 2 SLC44A2 0.002
3925 Choline transporter-like protein 4 SLC44A4 0.002
576 Choline O-acetyltransferase CHAT 0.002
3922 Phospholipase D2 PLD2 0.002
3924 Phospholipase D1 PLD1 0.002
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.002
76 Nitric-oxide synthase, brain NOS1 0.0019
867 Penicillin-binding protein 3 pbpC 0.0019
6119 Penicillin-binding protein 3 pbp3 0.0019
7154 Penicillin-binding protein 3 pbp3 0.0019
7157 Penicillin-binding protein 3 LMHCC_2184 0.0019
7162 Penicillin-binding protein 3 pbpB 0.0019
7172 Penicillin-binding protein 3 pbp3 0.0019
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0019
233 Potassium channel subfamily K member 2 KCNK2 0.0019
1654 Interleukin-1 beta IL1B 0.0019
6151 Monocarboxylate transporter 10 SLC16A10 0.0019
489 Monocarboxylate transporter 2 SLC16A7 0.0019
6163 Copper-transporting ATPase 2 ATP7B 0.0018
6165 Copper-transporting ATPase 1 ATP7A 0.0018
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0018
1968 ATP-sensitive inward rectifier potassium channel 12 KCNJ12 0.0018
5787 Angiopoietin-1 receptor TEK 0.0018
683 Potassium transporter GK0582 0.0018
53 Solute carrier family 12 member 5 SLC12A5 0.0018
663 Solute carrier family 12 member 4 SLC12A4 0.0018
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.0017
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0017
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.0017
6824 Tyrosine-protein kinase Lyn LYN 0.0017
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0017
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0017
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0017
1268 Neuropeptide S receptor NPSR1 0.0017
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0017
310 Solute carrier family 12 member 2 SLC12A2 0.0017
78 Acetyl-CoA acetyltransferase, mitochondrial ACAT1 0.0016
1243 Cathepsin D CTSD 0.0016
3233 Bile acid receptor NR1H4 0.0015
494 Caspase-1 CASP1 0.0015
6138 Multidrug resistance protein 3 ABCB4 0.0015
1507 Cytochrome c CYCS 0.0015
6073 Potassium channel subfamily K member 9 KCNK9 0.0015
6072 Potassium channel subfamily K member 3 KCNK3 0.0015
3844 HLA class II histocompatibility antigen, DQ(6) alpha chain HLA-DQA2 0.0015
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0015
1405 Thiopurine S-methyltransferase TPMT 0.0015
1541 Metalloproteinase mmp20 0.0014
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0014
3760 Penicillin-binding protein 5 precursor dacA 0.0014
6859 Protein S100-A4 S100A4 0.0014
2216 Fibroblast growth factor receptor 4 FGFR4 0.0014
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0013
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.0013
6184 D-alanyl-D-alanine carboxypeptidase dacC dacC 0.0013
561 Retinol-binding protein II, cellular RBP2 0.0013
35 Dehydrogenase/reductase SDR family member 4 DHRS4 0.0013
4073 Retinol dehydrogenase 11 RDH11 0.0013
4074 Retinol dehydrogenase 14 RDH14 0.0013
1097 Lecithin retinol acyltransferase LRAT 0.0013
589 Retinoid-binding protein 7 RBP7 0.0013
753 Retinol-binding protein III, cellular RBP5 0.0013
4071 Short-chain dehydrogenase/reductase 3 DHRS3 0.0013
4075 Photoreceptor outer segment all-trans retinol dehydrogenase RDH8 0.0013
863 Cellular retinaldehyde-binding protein RLBP1 0.0013
800 Retinol dehydrogenase 12 RDH12 0.0013
282 Interphotoreceptor retinoid-binding protein RBP3 0.0013
651 Retinol dehydrogenase 13 RDH13 0.0013
4072 All-trans-retinol 13,14-reductase RETSAT 0.0013
2077 Caspase-3 CASP3 0.0013
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0013
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0013
6116 Gastric triacylglycerol lipase LIPF 0.0012
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0012
819 Penicillin-binding protein 4 dacB 0.0012
3823 Cytokine receptor common gamma chain IL2RG 0.0012
85 Growth hormone receptor GHR 0.0012
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0012
2107 Microtubule-associated protein 1A MAP1A 0.0012
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0012
1295 Fatty acid synthase FASN 0.0012
702 UMP-CMP kinase CMPK1 0.0012
331 Retinol-binding protein I, cellular RBP1 0.0012
2207 Rhodopsin RHO 0.0011
2021 Thrombomodulin THBD 0.0011
627 11-cis retinol dehydrogenase RDH5 0.0011
640 Aldehyde dehydrogenase 1A3 ALDH1A3 0.0011
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0011
754 Pancreatic triacylglycerol lipase PNLIP 0.0011
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0011
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0011
2178 Metabotropic glutamate receptor 5 GRM5 0.0011
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0011
724 Interleukin-2 receptor alpha chain IL2RA 0.0011
717 Interleukin-2 receptor subunit beta IL2RB 0.0011
1810 Protein S100-A1 S100A1 0.001
6097 Protein S100-A2 S100A2 0.001
4116 Dihydropteroate synthetase Not Available 0.001
1144 Hepatocyte growth factor receptor MET 0.001
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.001
493 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial CYP27B1 0.001
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.001
345 Plasma retinol-binding protein RBP4 0.001
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.001
4041 Microsomal glutathione S-transferase 2 MGST2 0.001
229 Retinoic acid receptor beta RARB 0.0009
730 Retinoic acid receptor alpha RARA 0.0009
1048 Protein S100-A13 S100A13 0.0009
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0009
2226 Protein S100-A12 S100A12 0.0009
2132 Protein S100-B S100B 0.0009
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0008
3404 Exotoxin A eta 0.0008
5818 Folate receptor alpha FOLR1 0.0008
6042 Prostaglandin reductase 2 PTGR2 0.0008
3587 Gastrotropin FABP6 0.0008
760 Fibroblast growth factor 1 FGF1 0.0008
2232 Interleukin-5 IL5 0.0008
1593 Mucin-2 MUC2 0.0008
4031 Glutathione S-transferase A1 GSTA1 0.0008
1792 Tissue-type plasminogen activator PLAT 0.0008
1649 Small inducible cytokine A2 CCL2 0.0008
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0008
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.0007
473 L-lactate dehydrogenase A chain LDHA 0.0007
6103 Arylamine N-acetyltransferase 1 NAT1 0.0007
2290 ADP-ribosyl cyclase 2 BST1 0.0007
226 Gonadotropin-releasing hormone receptor GNRHR 0.0007
125 DNA polymerase beta POLB 0.0007
1123 Eosinophil cationic protein RNASE3 0.0007
2599 Tyrosine-protein kinase HCK HCK 0.0007
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0006
1313 Lactoylglutathione lyase GLO1 0.0006
144 Hemoglobin subunit alpha HBA1 0.0006
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0006
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0006
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0006
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0006
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0006
3611 Cytidine deaminase cdd 0.0006
3707 Cytidine deaminase cdd 0.0006
4211 Cytidine deaminase CDA 0.0006
1291 cAMP response element-binding protein CREB1 0.0006
4210 Toll-like receptor 4 TLR4 0.0005
1760 Aminopeptidase N ANPEP 0.0005
6843 Aminopeptidase N pepN 0.0005
1262 Corticotropin-lipotropin POMC 0.0005
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0005
6211 Tubulin epsilon chain TUBE1 0.0005
6212 Tubulin gamma-1 chain TUBG1 0.0005
6210 Tubulin delta chain TUBD1 0.0005
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0004
594 Thyroxine-binding globulin SERPINA7 0.0004
758 Thyroid hormone receptor alpha THRA 0.0003
2240 Cell division protein kinase 2 CDK2 0.0003
5798 Mitogen-activated protein kinase 11 MAPK11 0.0003
199 Monocarboxylate transporter 8 SLC16A2 0.0003
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0003
346 Thyroid hormone receptor beta-1 THRB 0.0003
6135 Sodium channel subunit beta-4 SCN4B 0.0002
6134 Sodium channel subunit beta-3 SCN3B 0.0002
6132 Sodium channel subunit beta-1 SCN1B 0.0002
6127 Carbonic anhydrase-related protein CA8 0.0002
6128 Carbonic anhydrase-related protein 10 CA10 0.0002
6133 Sodium channel subunit beta-2 SCN2B 0.0002
6129 Carbonic anhydrase-related protein 11 CA11 0.0002
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0002
6130 Carbonic anhydrase 13 CA13 0.0002
4936 Cytochrome c2 iso-2 Not Available 0.0001
4916 Cyanoglobin glbN 0.0001
4994 Hemoglobin-like protein HbO glbO 0.0001
4915 Cytochrome c-550 psbV 0.0001
4959 Cytochrome c-550 psbV 0.0001
5216 Cytochrome c-550 psbV 0.0001
4925 Cytochrome c-type protein SHP shp 0.0001
4904 Cytochrome c family protein GSU1996 0.0001
4943 Cytochrome c6 petJ 0.0001
3116 Bacterioferritin bfr 0.0001
4906 Bacterioferritin bfr 0.0001
4965 Bacterioferritin bfr 0.0001
4954 Soluble cytochrome b558 Not Available 0.0001
4934 Cytochrome c-551 nirM 0.0001
5218 Cytochrome c-551 nirM 0.0001
4905 Cytochrome c2 Not Available 0.0001
4939 Cytochrome c2 cycA 0.0001
4964 Cytochrome c2 cycA 0.0001
4979 Cytochrome c2 cycA 0.0001
6673 Cytochrome c2 cycA 0.0001
4910 Cytoglobin CYGB 0.0001
4984 Neuroglobin NGB 0.0001
4981 Iron-starvation protein PigA pigA 0.0001
4909 CooA protein cooA 0.0001
4998 Hemoglobin-like protein yjbI yjbI 0.0001
4935 Cytochrome c-554 cycA1 0.0001
4947 Bacterial hemoglobin vhb 0.0001
4975 Cytochrome c-556 RPA3973 0.0001
4942 Diheme cytochrome c napB napB 0.0001
4931 Cytochrome P450 167A1 CYP167A1 0.0001
5000 HemO hemO 0.0001
4972 P450cin cinA 0.0001
4960 Putative cytochrome P450-family protein SCO7417 0.0001
4971 Nonaheme cytochrome c hmcA 0.0001
4989 Cytochrome c551 peroxidase ccp 0.0001
5222 Cytochrome c551 peroxidase ccpA 0.0001
4961 Hemophore HasA hasA 0.0001
4976 Apocytochrome f petA 0.0001
6407 Apocytochrome f petA 0.0001
4907 Cytochrome c-L moxG 0.0001
6865 Cytochrome c-L moxG 0.0001
4993 Hydroxylamine oxidoreductase hao1 0.0001
4764 Cytochrome P450 165C4 CYP165C4 0.0001
4926 Heme-based aerotactic transducer hemAT hemAT 0.0001
644 Heme oxygenase 2 HMOX2 0.0001
4982 Heme oxygenase 2 pbsA2 0.0001
4952 Catalase/peroxidase katA 0.0001
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0001
4937 Cytochrome oxidase subunit II rcoxA 0.0001
4903 Methyl-accepting chemotaxis protein Tar4 0.0001
4999 Cytochrome P450 165B3 CYP165B3 0.0001
3093 Catalase HPII katE 0.0001
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0001
4922 Cytochrome c, putative SO_4144 0.0001
4920 Peroxidase/catalase katG 0.0001
4990 PpcA ppcA 0.0001
4948 Cytochrome c-553 Not Available 0.0001
4923 Cytochrome c3 DvMF_2499 0.0001
4945 Cytochrome c3 Not Available 0.0001
4949 Cytochrome c3 DVU_3171 0.0001
4968 Cytochrome c3 cytc3 0.0001
4997 Cytochrome c3 SO_2727 0.0001
5219 Cytochrome c3 cyd 0.0001
2119 Cytochrome b5 CYB5A 0.0001
4902 Nine-heme cytochrome c Ddes_2038 0.0001
3189 High-molecular-weight cytochrome c hmcA 0.0001
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0001
3375 Acidic cytochrome c3 Not Available 0.0001
4988 Sulfite oxidase, mitochondrial SUOX 0.0001
2915 Sensor protein fixL fixL 0.0001
4944 Sensor protein fixL fixL 0.0001
4813 Heme oxygenase hmuO 0.0001
5769 Heme oxygenase Not Available 0.0001
3570 Cytochrome P450 152A1 cypC 0.0001
4385 Cytochrome c' Not Available 0.0001
4967 Cytochrome c' cycA 0.0001
5038 Cytochrome c' Not Available 0.0001
5223 Cytochrome c' cycP 0.0001
4037 Hypothetical protein GPX1 0.0001
4297 Hypothetical protein SP_1951 0.0001
4521 Hypothetical protein BC_2969 0.0001
4540 Hypothetical protein TM_1070 0.0001
4555 Hypothetical protein MT1739 0.0001
4569 Hypothetical protein mshD 0.0001
4578 Hypothetical protein PA3270 0.0001
4747 Hypothetical protein PA3967 0.0001
5177 Hypothetical protein TM_0096 0.0001
5194 Hypothetical protein PA1204 0.0001
5240 Hypothetical protein Rv2991 0.0001
5370 Hypothetical protein TM_1158 0.0001
5710 Hypothetical protein Tb927.5.1360 0.0001
4289 Cytochrome P450 TT_P0059 0.0001
6262 Cytochrome P450 staP 0.0001
4992 Cytochrome c peroxidase Not Available 0.0001
3670 Soluble cytochrome b562 precursor cybC 0.0001
3411 Cytochrome P450 121 cyp121 0.0001
3291 Cytochrome c-552 cycA 0.0001
4927 Cytochrome c-552 nrfA 0.0001
4938 Cytochrome c-552 cycA 0.0001
4953 Cytochrome c-552 nrfA 0.0001
5217 Cytochrome c-552 cycM 0.0001
2617 Nitric oxide synthase oxygenase nos 0.0001
2701 Nitric oxide synthase oxygenase nos 0.0001
3102 Flavohemoprotein hmp 0.0001
4969 Flavohemoprotein hmp 0.0001
4386 Hemoglobin-like protein HbN glbN 0.0001
3127 Nitrite reductase nirS 0.0001
3284 Nitrite reductase nirS 0.0001
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0001
2972 6-deoxyerythronolide B hydroxylase eryF 0.0001
3221 Cytochrome c4 cc4 0.0001
4608 Putative cytochrome P450 SCO1207 0.0001
4963 Putative cytochrome P450 SCO2884 0.0001
6254 Putative cytochrome P450 SCO6998 0.0001
358 Cystathionine beta-synthase CBS 0
693 Hemoglobin subunit beta HBB 0
6268 Hydroxyacid oxidase 1 HAO1 0
810 Heme oxygenase 1 HMOX1 0
3391 Heme oxygenase 1 pbsA1 0
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