DT-Web

DB01195 - Flecainide


Identification
Name Flecainide
Accession Number DB01195 (APRD00129)
Type small molecule
Description A potent anti-arrhythmia agent, effective in a wide range of ventricular and atrial arrhythmias and tachycardias. Paradoxically, however, in myocardial infarct patients with either symptomatic or asymptomatic arrhythmia, flecainide exacerbates the arrhythmia and is not recommended for use in these patients. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 414.3427
Groups approved
Monoisotopic Weight 414.137811746
Pharmacology
Indication Flecainide is is a class Ic antiarrhythmic agent and as such, it is used for the prevention of paroxysmal supraventricular tachycardias (PSVT), including atrioventricular nodal reentrant tachycardia, atrioventricular reentrant tachycardia and other supraventricular tachycardias of unspecified mechanism associated with disablin.
Mechanism of action Flecainide acts on sodium channels on the neuronal cell membrane, limiting the spread of seizure activity and reducing seizure propagation. The antiarrhythmic actions are mediated through effects on sodium channels in Purkinje fibers. Flecainide is a sodium channel blocker, binding to voltage gated sodium channels. It stabilizes the neuronal membrane by inhibiting the ionic fluxes required for the initiation and conduction of impulses. Ventricular excitability is depressed and the stimulation threshold of the ventricle is increased during diastole.
Absorption Nearly complete following oral administration.
Protein binding 40%
Biotransformation Hepatic. Flecainide does not undergo any consequential presystemic biotransformation. The two major urinary metabolites are meta-O-dealkylated flecainide (active, but about one-fifth as potent) and the meta-O-dealkylated lactam of flecainide (non-active metabolite).
Route of elimination In healthy subjects, about 30% of a single oral dose (range, 10 to 50%) is excreted in urine as unchanged drug. Several minor metabolites (3% of the dose or less) are also found in urine; only 5% of an oral dose is excreted in feces. In patients, free (unconjugated) plasma levels of the two major metabolites are very low (less than 0.05 ?g/mL).
Toxicity Oral LD50 is 50-498 mg/kg in rat. Symptoms of overdose include nausea and vomiting, convulsions, hypotension, bradycardia, syncope, extreme widening of the QRS complex, widening of the QT interval, widening of the PR interval, ventricular tachycardia, AV nodal block, asystole, bundle branch block, cardiac failure, and cardiac arrest.
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Amiodarone Amiodarone may increase the effect and toxicity of flecainide
Artemether Additive QTc-prolongation may occur. Concomitant therapy should be avoided.
Cimetidine Cimetidine, a moderate CYP2D6 inhibitor, may decrease the metabolism of flecainide.
Cisapride Increased risk of cardiotoxicity and arrhythmias
Duloxetine Possible increase in the levels of this agent when used with duloxetine
Etravirine Flecainide, when administered concomitantly with etravirine, may experience a decrease in serum concentration. It is recommended to monitor flecainide therapy.
Lumefantrine Additive QTc-prolongation may occur. Concomitant therapy should be avoided.
Mesoridazine Increased risk of cardiotoxicity and arrhythmias
Mirabegron Mirabegron is a moderate CYP2D6 inhibitor and may cause an increase in exposure of CYP2D6 substrates. Monitor concomitant therapy closely.
Quinupristin This combination presents an increased risk of toxicity
Ritonavir Ritonavir increases the toxicity of the anti-arrhythmic
Tacrolimus Additive QTc-prolongation may occur increasing the risk of serious ventricular arrhythmias. Concomitant therapy should be used with caution.
Terbinafine Terbinafine may reduce the metabolism and clearance of Flecainide. Consider alternate therapy or monitor for therapeutic/adverse effects of Flecainide if Terbinafine is initiated, discontinued or dose changed.
Terfenadine Increased risk of cardiotoxicity and arrhythmias
Thioridazine Increased risk of cardiotoxicity and arrhythmias
Thiothixene May cause additive QTc-prolonging effects. Increased risk of ventricular arrhythmias. Consider alternate therapy. Thorough risk:benefit assessment is required prior to co-administration.
Tipranavir Tipranavir, co-administered with Ritonavir, may increase the plasma concentration of Flecainide. Concomitant therapy is contraindicated.
Toremifene Additive QTc-prolongation may occur, increasing the risk of serious ventricular arrhythmias. Consider alternate therapy. A thorough risk:benefit assessment is required prior to co-administration.
Trimipramine Additive QTc-prolongation may occur, increasing the risk of serious ventricular arrhythmias. Concomitant therapy should be used with caution.
Voriconazole Additive QTc prolongation may occur. Consider alternate therapy or monitor for QTc prolongation as this can lead to Torsade de Pointes (TdP).
Vorinostat Additive QTc prolongation may occur. Consider alternate therapy or monitor for QTc prolongation as this can lead to Torsade de Pointes (TdP).
Ziprasidone Additive QTc-prolonging effects may increase the risk of severe arrhythmias. Concomitant therapy is contraindicated.
Zuclopenthixol Additive QTc prolongation may occur. Consider alternate therapy or use caution and monitor for QTc prolongation as this can lead to Torsade de Pointes (TdP).
Food Interactions
  • Take without regard to meals.

Targets


Sodium channel protein type 5 subunit alpha
Name Sodium channel protein type 5 subunit alpha
Gene Name SCN5A
Pharmacological action yes
Actions inhibitor
References
  • Nagatomo T, January CT, Makielski JC: Preferential block of late sodium current in the LQT3 DeltaKPQ mutant by the class I(C) antiarrhythmic flecainide. Mol Pharmacol. 2000 Jan;57(1):101-7. - Pubmed
  • Benhorin J, Taub R, Goldmit M, Kerem B, Kass RS, Windman I, Medina A: Effects of flecainide in patients with new SCN5A mutation: mutation-specific therapy for long-QT syndrome? Circulation. 2000 Apr 11;101(14):1698-706. - Pubmed
  • Priori SG, Napolitano C, Schwartz PJ, Bloise R, Crotti L, Ronchetti E: The elusive link between LQT3 and Brugada syndrome: the role of flecainide challenge. Circulation. 2000 Aug 29;102(9):945-7. - Pubmed
  • Cerrone M, Crotti L, Faggiano G, De Michelis V, Napolitano C, Schwartz PJ, Priori SG: [Long QT syndrome and Brugada syndrome: 2 aspects of the same disease?] Ital Heart J Suppl. 2001 Mar;2(3):253-7. - Pubmed
  • Viswanathan PC, Bezzina CR, George AL Jr, Roden DM, Wilde AA, Balser JR: Gating-dependent mechanisms for flecainide action in SCN5A-linked arrhythmia syndromes. Circulation. 2001 Sep 4;104(10):1200-5. - Pubmed
  • Ramos E, O'leary ME: State-dependent trapping of flecainide in the cardiac sodium channel. J Physiol. 2004 Oct 1;560(Pt 1):37-49. Epub 2004 Jul 22. - Pubmed
  • Shimizu W, Antzelevitch C, Suyama K, Kurita T, Taguchi A, Aihara N, Takaki H, Sunagawa K, Kamakura S: Effect of sodium channel blockers on ST segment, QRS duration, and corrected QT interval in patients with Brugada syndrome. J Cardiovasc Electrophysiol. 2000 Dec;11(12):1320-9. - Pubmed
  • Liu H, Atkins J, Kass RS: Common molecular determinants of flecainide and lidocaine block of heart Na+ channels: evidence from experiments with neutral and quaternary flecainide analogues. J Gen Physiol. 2003 Mar;121(3):199-214. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score 0.5225
Sodium channel protein type 4 subunit alpha
Name Sodium channel protein type 4 subunit alpha
Gene Name SCN4A
Pharmacological action yes
Actions inhibitor
References
  • Desaphy JF, De Luca A, Didonna MP, George AL Jr, Camerino Conte D: Different flecainide sensitivity of hNav1.4 channels and myotonic mutants explained by state-dependent block. J Physiol. 2004 Jan 15;554(Pt 2):321-34. Epub 2003 Nov 7. - Pubmed
DTHybrid score 0.1663

Enzymes


Cytochrome P450 2D6
Name Cytochrome P450 2D6
Gene Name CYP2D6
Actions substrate,inhibitor
References
  • Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.3544
Cytochrome P450 2C9
Name Cytochrome P450 2C9
Gene Name CYP2C9
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.2971

Predictions


Id Partner name Gene Name Score
4512 Cytochrome P450 3A4 CYP3A4 0.1881
6016 Cytochrome P450 2C19 CYP2C19 0.1602
4200 Cytochrome P450 1A2 CYP1A2 0.127
4924 Cytochrome P450 2C8 CYP2C8 0.1232
6030 Cytochrome P450 2B6 CYP2B6 0.0882
1588 Multidrug resistance protein 1 ABCB1 0.0776
4118 Cytochrome P450 3A5 CYP3A5 0.069
6013 Cytochrome P450 2E1 CYP2E1 0.0658
587 Serum albumin ALB 0.0607
6107 Cytochrome P450 3A7 CYP3A7 0.0537
6024 Cytochrome P450 1A1 CYP1A1 0.0523
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0472
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0454
20 Prostaglandin G/H synthase 1 PTGS1 0.0448
5718 Cytochrome P450 2A6 CYP2A6 0.0447
6106 Cytochrome P450 2C18 CYP2C18 0.0404
492 Histamine H1 receptor HRH1 0.0355
824 Sodium-dependent serotonin transporter SLC6A4 0.0333
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0323
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0303
465 Calmodulin CALM1 0.0295
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0279
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0273
290 Prostaglandin G/H synthase 2 PTGS2 0.0266
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0266
6145 Solute carrier family 22 member 1 SLC22A1 0.0249
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0247
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0233
502 5-hydroxytryptamine 2A receptor HTR2A 0.0229
831 D(2) dopamine receptor DRD2 0.0229
6144 Solute carrier family 22 member 2 SLC22A2 0.0228
118 Organic cation/carnitine transporter 2 SLC22A5 0.0211
766 Beta-2 adrenergic receptor ADRB2 0.021
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.021
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0209
713 Sodium-dependent dopamine transporter SLC6A3 0.0209
862 Multidrug resistance-associated protein 1 ABCC1 0.0206
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0205
556 Alpha-1A adrenergic receptor ADRA1A 0.0202
1898 Cytochrome P450 1B1 CYP1B1 0.02
1729 Solute carrier family 22 member 6 SLC22A6 0.0195
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0191
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0186
193 Beta-1 adrenergic receptor ADRB1 0.018
3941 Amine oxidase [flavin-containing] A MAOA 0.0179
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0172
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0172
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0171
3923 Cholinesterase BCHE 0.0166
2164 Multidrug resistance-associated protein 4 ABCC4 0.016
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0158
3939 Amine oxidase [flavin-containing] B MAOB 0.0156
172 Potassium channel subfamily K member 1 KCNK1 0.0156
6135 Sodium channel subunit beta-4 SCN4B 0.0152
6134 Sodium channel subunit beta-3 SCN3B 0.0152
6132 Sodium channel subunit beta-1 SCN1B 0.0152
6133 Sodium channel subunit beta-2 SCN2B 0.0152
6127 Carbonic anhydrase-related protein CA8 0.0152
6128 Carbonic anhydrase-related protein 10 CA10 0.0152
6129 Carbonic anhydrase-related protein 11 CA11 0.0152
590 5-hydroxytryptamine 2C receptor HTR2C 0.0149
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0146
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0146
847 Mu-type opioid receptor OPRM1 0.0146
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0146
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0144
6142 Solute carrier family 22 member 8 SLC22A8 0.0142
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0142
320 5-hydroxytryptamine 1A receptor HTR1A 0.0141
833 Organic cation/carnitine transporter 1 SLC22A4 0.0139
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0139
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0134
341 5-hydroxytryptamine 3 receptor HTR3A 0.0134
318 Alpha-2A adrenergic receptor ADRA2A 0.0132
6126 Carbonic anhydrase 7 CA7 0.0128
23 D(1A) dopamine receptor DRD1 0.0128
891 Dihydropteroate synthase folP 0.0128
5359 Dihydropteroate synthase folP 0.0128
7175 Dihydropteroate synthase sulI 0.0128
3937 Fatty-acid amide hydrolase FAAH 0.0128
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0125
632 Alpha-1B adrenergic receptor ADRA1B 0.0125
6130 Carbonic anhydrase 13 CA13 0.0124
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0123
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0123
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0121
6220 Aryl hydrocarbon receptor AHR 0.0118
467 Delta-type opioid receptor OPRD1 0.0118
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0118
592 Carbonic anhydrase 4 CA4 0.0117
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0117
6131 Carbonic anhydrase 14 CA14 0.0117
295 Carbonic anhydrase 1 CA1 0.0117
696 Kappa-type opioid receptor OPRK1 0.0116
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0115
1024 Solute carrier family 22 member 11 SLC22A11 0.0113
6122 Carbonic anhydrase 3 CA3 0.011
6147 Solute carrier family 22 member 3 SLC22A3 0.0109
776 Bile salt export pump ABCB11 0.0107
275 Arachidonate 5-lipoxygenase ALOX5 0.0107
731 HIV-1 protease HIV-1 protease 0.0105
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0104
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0103
33 Cystine/glutamate transporter SLC7A11 0.0103
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0101
4205 Carbonic anhydrase 9 CA9 0.01
3007 Carbonic anhydrase 12 CA12 0.01
2981 Phospholipase A2, membrane associated PLA2G2A 0.0096
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0093
638 D(3) dopamine receptor DRD3 0.0089
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0085
357 Carbonic anhydrase 2 CA2 0.0084
373 Transthyretin TTR 0.0084
921 Glutamate receptor 2 GRIA2 0.0084
3811 Cytochrome P450 19A1 CYP19A1 0.0082
122 P2Y purinoceptor 12 P2RY12 0.0082
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0081
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0081
6020 Aldehyde oxidase AOX1 0.0078
136 Estrogen receptor ESR1 0.0077
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0075
70 Type-1 angiotensin II receptor AGTR1 0.0074
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0074
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0073
629 Alpha-2B adrenergic receptor ADRA2B 0.0072
432 D(4) dopamine receptor DRD4 0.0071
885 5-hydroxytryptamine 1B receptor HTR1B 0.0071
1064 DNA (cytosine-5)-methyltransferase 1 DNMT1 0.007
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0069
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0069
436 5-hydroxytryptamine 2B receptor HTR2B 0.0068
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0067
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0067
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0065
474 Acetylcholinesterase ACHE 0.0064
844 Epidermal growth factor receptor EGFR 0.0064
6143 Solute carrier family 22 member 7 SLC22A7 0.0063
133 Dihydropterate synthase sulI 0.0063
789 Alpha-1D adrenergic receptor ADRA1D 0.0062
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0062
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0062
4116 Dihydropteroate synthetase Not Available 0.0062
6031 Cytochrome P450 3A43 CYP3A43 0.0061
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0059
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0059
378 Alpha-2C adrenergic receptor ADRA2C 0.0059
817 DNA topoisomerase 2-alpha TOP2A 0.0059
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0058
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0058
94 5-hydroxytryptamine 4 receptor HTR4 0.0056
6182 Cytochrome P450 2J2 CYP2J2 0.0056
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0055
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0054
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0053
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0053
163 D(1B) dopamine receptor DRD5 0.0053
131 Synaptic vesicular amine transporter SLC18A2 0.0053
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0052
365 Dihydrofolate reductase DHFR 0.0052
2381 Dihydrofolate reductase DFR1 0.0052
2833 Dihydrofolate reductase Not Available 0.0052
2931 Dihydrofolate reductase folA 0.0052
3544 Dihydrofolate reductase folA 0.0052
3682 Dihydrofolate reductase folA 0.0052
6642 Dihydrofolate reductase folA 0.0052
6756 Dihydrofolate reductase dfrA 0.0052
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0051
725 5-hydroxytryptamine 1D receptor HTR1D 0.005
3810 Catechol O-methyltransferase COMT 0.0049
380 Cytochrome P450 17A1 CYP17A1 0.0048
146 Androgen receptor AR 0.0048
468 Cytochrome P450 4A11 CYP4A11 0.0047
260 Cytochrome P450 51 ERG11 0.0047
761 Cytochrome P450 51 ERG11 0.0047
3163 Cytochrome P450 51 cyp51 0.0047
527 Prostacyclin receptor PTGIR 0.0045
2112 Toll-like receptor 9 TLR9 0.0044
49 Endothelin B receptor EDNRB 0.0044
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0043
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0042
578 Endothelin-1 receptor EDNRA 0.0041
504 Mast/stem cell growth factor receptor KIT 0.0041
124 Histamine H2 receptor HRH2 0.004
4203 Histamine N-methyltransferase HNMT 0.004
1275 Estrogen sulfotransferase SULT1E1 0.004
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.004
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.0039
6102 Arylamine N-acetyltransferase 2 NAT2 0.0039
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0038
716 5-hydroxytryptamine 7 receptor HTR7 0.0038
6148 Multidrug resistance-associated protein 7 ABCC10 0.0038
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0038
4604 Liver carboxylesterase 1 CES1 0.0038
6136 Multidrug resistance-associated protein 5 ABCC5 0.0037
130 Prostacyclin synthase PTGIS 0.0037
751 Potassium channel subfamily K member 6 KCNK6 0.0036
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0035
1757 Myeloperoxidase MPO 0.0035
1656 CYP2B protein CYP2B 0.0035
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0034
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0034
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0034
6137 Multidrug resistance-associated protein 6 ABCC6 0.0034
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0033
6506 Stathmin-4 STMN4 0.0033
173 Toll-like receptor 7 TLR7 0.0033
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0033
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0032
482 Glycine receptor subunit alpha-1 GLRA1 0.0032
161 Tubulin beta chain TUBB 0.0032
312 Tubulin beta chain TUB2 0.0032
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0032
407 Vascular endothelial growth factor receptor 2 KDR 0.0032
811 Translocator protein TSPO 0.0032
1636 Trace amine-associated receptor 1 TAAR1 0.0031
738 Monocarboxylate transporter 1 SLC16A1 0.0031
1256 5-hydroxytryptamine 6 receptor HTR6 0.0031
1227 Cytochrome b MT-CYB 0.0031
6386 Cytochrome b petB 0.0031
6937 Cytochrome b MT-CYB 0.0031
674 Dihydroorotate dehydrogenase homolog, mitochondrial PFF0160c 0.0031
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.0031
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0031
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.003
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.003
4120 NADPH--cytochrome P450 reductase POR 0.0029
183 Vascular endothelial growth factor A VEGFA 0.0029
528 5-hydroxytryptamine 1E receptor HTR1E 0.0029
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0029
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0029
565 Extracellular calcium-sensing receptor CASR 0.0028
208 DNA-directed RNA polymerase beta' chain rpoC 0.0028
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0028
777 Tumor necrosis factor TNF 0.0028
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0028
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0028
1200 AMBP protein AMBP 0.0028
3866 Serum amyloid A protein SAA1 0.0028
1932 Apolipoprotein E APOE 0.0028
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0028
1178 Adenosine A2a receptor ADORA2A 0.0027
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0027
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0027
2159 Quinone oxidoreductase CRYZ 0.0027
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0027
1010 Cytochrome P450 51A1 CYP51A1 0.0027
24 Thymidylate synthase TMP1 0.0027
359 Thymidylate synthase TYMS 0.0027
2626 Thymidylate synthase thyA 0.0027
2729 Thymidylate synthase thyA 0.0027
5352 Thymidylate synthase THYA 0.0027
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0027
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0027
6014 Cytochrome P450 2A13 CYP2A13 0.0027
1629 Transcription factor AP-1 JUN 0.0026
54 Prothrombin F2 0.0026
571 Melatonin receptor type 1A MTNR1A 0.0026
362 Melatonin receptor type 1B MTNR1B 0.0026
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0026
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0026
174 Sigma 1-type opioid receptor SIGMAR1 0.0026
6085 Fatty acid-binding protein, intestinal FABP2 0.0026
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0025
427 Substance-P receptor TACR1 0.0025
6141 Sodium/bile acid cotransporter SLC10A1 0.0025
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0025
1541 Metalloproteinase mmp20 0.0025
614 Progesterone receptor PGR 0.0025
153 Dopamine beta-hydroxylase DBH 0.0024
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0024
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0024
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0024
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0024
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0024
952 Dipeptidyl peptidase 4 DPP4 0.0023
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0023
459 Retinoic acid receptor RXR-alpha RXRA 0.0023
228 Beta platelet-derived growth factor receptor PDGFRB 0.0023
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0022
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0022
3947 Xanthine dehydrogenase/oxidase XDH 0.0022
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0022
164 Histamine H4 receptor HRH4 0.0022
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0021
518 Peroxidase/catalase T katG 0.0021
780 Retinoic acid receptor RXR-gamma RXRG 0.0021
871 Glucocorticoid receptor NR3C1 0.0021
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0021
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0021
63 Malate dehydrogenase mdh 0.0021
2329 Malate dehydrogenase mdh 0.0021
3445 Malate dehydrogenase mdh 0.0021
4420 Malate dehydrogenase mdh 0.0021
4438 Malate dehydrogenase mdh 0.0021
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.002
869 Estrogen receptor beta ESR2 0.002
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.002
1502 Peroxisome proliferator-activated receptor delta PPARD 0.002
563 Thyroid peroxidase TPO 0.0019
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0019
88 Retinoic acid receptor RXR-beta RXRB 0.0019
1050 Bile salt sulfotransferase SULT2A1 0.0019
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0019
3639 Thymidine phosphorylase deoA 0.0019
3936 Thymidine phosphorylase TYMP 0.0019
4122 Histone deacetylase 2 HDAC2 0.0019
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0019
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0019
16 Adenosine A1 receptor ADORA1 0.0019
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0018
893 [Citrate [pro-3S]-lyase] ligase citC 0.0018
845 Pyruvate dehydrogenase [cytochrome] poxB 0.0018
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0018
634 Squalene monooxygenase SQLE 0.0018
7196 Squalene monooxygenase ERG1 0.0018
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0018
327 Glutathione reductase gor 0.0018
5110 Glutathione reductase GR2 0.0018
1618 High affinity nerve growth factor receptor NTRK1 0.0018
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0018
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.0018
1341 Histamine H3 receptor HRH3 0.0018
537 ATP synthase delta chain, mitochondrial ATP5D 0.0017
1192 Sulfotransferase 1A1 SULT1A1 0.0017
26 Vascular endothelial growth factor receptor 3 FLT4 0.0017
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.0017
1144 Hepatocyte growth factor receptor MET 0.0017
823 Fibroblast growth factor receptor 2 FGFR2 0.0017
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0017
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0017
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0017
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0017
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0017
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0017
992 Protein tyrosine kinase 2 beta PTK2B 0.0017
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0017
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0017
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0017
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0017
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0017
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0017
32 Vascular endothelial growth factor receptor 1 FLT1 0.0016
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0016
4228 Keratin, type II cytoskeletal 7 KRT7 0.0016
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0016
6146 High affinity copper uptake protein 1 SLC31A1 0.0016
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0016
1648 Elastin ELN 0.0015
2853 14 kDa fatty acid-binding protein Not Available 0.0015
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0015
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0015
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0015
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0015
982 Cocaine- and amphetamine-regulated transcript protein CARTPT 0.0015
581 Cytochrome P450 2R1 CYP2R1 0.0015
558 Solute carrier family 12 member 1 SLC12A1 0.0015
1517 Beta-3 adrenergic receptor ADRB3 0.0015
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0015
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0015
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0015
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0015
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0015
3611 Cytidine deaminase cdd 0.0014
3707 Cytidine deaminase cdd 0.0014
4211 Cytidine deaminase CDA 0.0014
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0014
756 Sex hormone-binding globulin SHBG 0.0014
4773 Deoxycytidine kinase DCK 0.0014
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0014
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0014
3086 Plasmepsin-2 Not Available 0.0014
1992 Vitamin D-binding protein GC 0.0014
319 Opioid receptor, sigma 1 OPRS1 0.0014
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0014
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0014
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0014
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0014
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0014
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0014
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0014
4148 Serine/threonine-protein kinase mTOR MTOR 0.0014
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0014
2232 Interleukin-5 IL5 0.0014
737 Mineralocorticoid receptor NR3C2 0.0014
1593 Mucin-2 MUC2 0.0014
976 Platelet glycoprotein IX GP9 0.0013
3404 Exotoxin A eta 0.0013
4103 Proteasome subunit beta type 2 PSMB2 0.0013
4102 Proteasome subunit beta type 5 PSMB5 0.0013
1630 Integrin beta-2 ITGB2 0.0013
4101 Proteasome subunit beta type 1 PSMB1 0.0013
1374 Natriuretic peptides B NPPB 0.0013
1827 Gap junction alpha-1 protein GJA1 0.0013
1908 Vascular cell adhesion protein 1 VCAM1 0.0013
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0013
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0013
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0013
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0013
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0013
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0013
860 Nicotinamide N-methyltransferase NNMT 0.0013
699 Nicotinic acid receptor 1 GPR109A 0.0013
928 Nicotinic acid receptor 2 GPR109B 0.0013
583 Nicotinate-nucleotide pyrophosphorylase [carboxylating] QPRT 0.0013
2442 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
2459 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
6103 Arylamine N-acetyltransferase 1 NAT1 0.0013
84 Nuclear receptor 0B1 NR0B1 0.0013
814 Ryanodine receptor 1 RYR1 0.0013
511 5-hydroxytryptamine 1F receptor HTR1F 0.0012
6432 Transporter snf 0.0012
232 Corticosteroid-binding globulin SERPINA6 0.0012
165 FL cytokine receptor FLT3 0.0012
7 Nitric oxide synthase, inducible NOS2 0.0012
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0012
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0012
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0012
3856 Fibroblast growth factor receptor 3 FGFR3 0.0012
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0012
29 Tubulin beta-1 chain TUBB1 0.0012
705 Glutamate receptor 1 GRIA1 0.0012
6149 Solute carrier family 22 member 10 SLC22A10 0.0011
473 L-lactate dehydrogenase A chain LDHA 0.0011
6048 Troponin C, skeletal muscle TNNC2 0.0011
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0011
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0011
1123 Eosinophil cationic protein RNASE3 0.0011
268 Adenosine A2b receptor ADORA2B 0.0011
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0011
707 72 kDa type IV collagenase MMP2 0.0011
2183 Fatty acid-binding protein, adipocyte FABP4 0.0011
6044 Serum paraoxonase/lactonase 3 PON3 0.0011
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0011
106 Cannabinoid receptor 2 CNR2 0.0011
6174 50S ribosomal protein L32 rpmF 0.0011
4238 50S ribosomal protein L4 rplD 0.0011
5578 50S ribosomal protein L4 rplD 0.0011
6173 50S ribosomal protein L4 rplD 0.0011
6219 50S ribosomal protein L4 rplD 0.0011
856 Vitamin D3 receptor VDR 0.0011
2290 ADP-ribosyl cyclase 2 BST1 0.001
1196 Complement decay-accelerating factor CD55 0.001
6033 High affinity interleukin-8 receptor A CXCR1 0.001
2300 Lysozyme E 0.001
3633 Lysozyme R 0.001
5597 Lysozyme 17 0.001
3809 Estrogen-related receptor gamma ESRRG 0.001
4311 tRNA TRDMT1 0.001
4325 tRNA trmD 0.001
4328 tRNA trmD 0.001
68 Cannabinoid receptor 1 CNR1 0.001
572 Integrin alpha-L ITGAL 0.001
3868 Calcineurin subunit B isoform 2 PPP3R2 0.001
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.001
6138 Multidrug resistance protein 3 ABCB4 0.001
144 Hemoglobin subunit alpha HBA1 0.001
1864 RET proto-oncogene RET 0.001
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.001
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.001
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.001
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0009
65 Matrix metalloproteinase-9 Not Available 0.0009
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0009
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0009
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0009
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0009
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0009
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0009
1268 Neuropeptide S receptor NPSR1 0.0009
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0009
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0009
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0009
2808 Chloramphenicol acetyltransferase 3 cat3 0.0009
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.0009
5934 Cytochrome P450 26A1 CYP26A1 0.0009
1262 Corticotropin-lipotropin POMC 0.0008
273 Apoptosis regulator Bcl-2 BCL2 0.0008
3808 Dihydropteroate synthase 2 folP2 0.0008
3601 Dihydropteroate synthase 1 folP1 0.0008
3807 Dihydropteroate synthase 1 folP1 0.0008
3932 Glutathione S-transferase A2 GSTA2 0.0008
2417 Chloramphenicol acetyltransferase cat 0.0008
3278 Chloramphenicol acetyltransferase cat 0.0008
6073 Potassium channel subfamily K member 9 KCNK9 0.0008
6072 Potassium channel subfamily K member 3 KCNK3 0.0008
5787 Angiopoietin-1 receptor TEK 0.0008
2810 Dr hemagglutinin structural subunit draA 0.0008
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0008
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0008
244 Angiotensin-converting enzyme ACE 0.0008
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0008
6212 Tubulin gamma-1 chain TUBG1 0.0008
6210 Tubulin delta chain TUBD1 0.0008
6211 Tubulin epsilon chain TUBE1 0.0008
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0008
500 Monocarboxylate transporter 4 SLC16A3 0.0008
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0008
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0008
904 Glutathione S-transferase P GSTP1 0.0008
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0008
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0008
3830 Calreticulin CALR 0.0008
866 Large neutral amino acids transporter small subunit 2 SLC7A8 0.0007
3957 Adenosine deaminase ADA 0.0007
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0007
4948 Cytochrome c-553 Not Available 0.0007
4923 Cytochrome c3 DvMF_2499 0.0007
4945 Cytochrome c3 Not Available 0.0007
4949 Cytochrome c3 DVU_3171 0.0007
4968 Cytochrome c3 cytc3 0.0007
4997 Cytochrome c3 SO_2727 0.0007
5219 Cytochrome c3 cyd 0.0007
4902 Nine-heme cytochrome c Ddes_2038 0.0007
3189 High-molecular-weight cytochrome c hmcA 0.0007
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0007
291 Nitric-oxide synthase, endothelial NOS3 0.0007
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0007
6034 Hydroxyindole O-methyltransferase ASMT 0.0007
6035 Nuclear receptor ROR-beta RORB 0.0007
6036 Eosinophil peroxidase EPX 0.0007
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0007
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0007
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0007
469 Annexin A1 ANXA1 0.0007
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0007
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0007
4226 Uridine phosphorylase 2 UPP2 0.0007
4217 Telomerase reverse transcriptase TERT 0.0007
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0006
239 Coagulation factor X F10 0.0006
2207 Rhodopsin RHO 0.0006
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0006
4386 Hemoglobin-like protein HbN glbN 0.0006
251 Alcohol dehydrogenase 1A ADH1A 0.0006
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0006
765 Indoleamine 2,3-dioxygenase IDO1 0.0006
2216 Fibroblast growth factor receptor 4 FGFR4 0.0006
4225 Uridine phosphorylase 1 UPP1 0.0006
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0006
719 Retinoic acid receptor responder protein 1 RARRES1 0.0006
770 Retinoic acid-induced protein 3 GPRC5A 0.0006
820 Glycine receptor subunit alpha-2 GLRA2 0.0006
2449 Tubulin alpha-3 chain TUBA1A 0.0006
413 Amidophosphoribosyltransferase PPAT 0.0006
2515 Amidophosphoribosyltransferase purF 0.0006
3714 Amidophosphoribosyltransferase purF 0.0006
828 Phenylalanine-4-hydroxylase PAH 0.0006
3109 Phenylalanine-4-hydroxylase phhA 0.0006
3221 Cytochrome c4 cc4 0.0006
2021 Thrombomodulin THBD 0.0006
5221 Cytochrome c3, 13 kDa Not Available 0.0006
3152 Cytochrome c'' cycA 0.0006
5220 Split-Soret cytochrome c Ddes_2150 0.0006
3700 Cytochrome c-552 precursor nrfA 0.0006
444 Alcohol dehydrogenase 1B ADH1B 0.0005
543 Penicillin-binding protein 1B mrcB 0.0005
6186 Penicillin-binding protein 1B ponB 0.0005
6822 Penicillin-binding protein 1b pbp1b 0.0005
6844 Penicillin-binding protein 1b pbp1b 0.0005
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0005
645 Penicillin-binding protein 1A mrcA 0.0005
5805 Penicillin-binding protein 1A ponA 0.0005
6185 Penicillin-binding protein 1A mrcA 0.0005
6799 Penicillin-binding protein 1A pbpA 0.0005
159 Penicillin-binding protein 2B penA 0.0005
6121 Penicillin-binding protein 2B penA 0.0005
5924 Microtubule-associated protein 4 MAP4 0.0005
5923 Microtubule-associated protein tau MAPT 0.0005
5798 Mitogen-activated protein kinase 11 MAPK11 0.0005
2320 Thymidine kinase, cytosolic TK1 0.0005
267 Plasminogen activator inhibitor 1 SERPINE1 0.0005
569 Retinal dehydrogenase 2 ALDH1A2 0.0005
6151 Monocarboxylate transporter 10 SLC16A10 0.0005
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0005
1852 Microtubule-associated protein 2 MAP2 0.0005
611 Retinal dehydrogenase 1 ALDH1A1 0.0005
3127 Nitrite reductase nirS 0.0005
3284 Nitrite reductase nirS 0.0005
1507 Cytochrome c CYCS 0.0005
517 Alcohol dehydrogenase 1C ADH1C 0.0005
6218 Pannexin-1 PANX1 0.0005
233 Potassium channel subfamily K member 2 KCNK2 0.0005
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0005
6221 Steroid hormone receptor ERR1 ESRRA 0.0005
6824 Tyrosine-protein kinase Lyn LYN 0.0005
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0005
1039 Histone deacetylase 9 HDAC9 0.0004
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0004
760 Fibroblast growth factor 1 FGF1 0.0004
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0004
3917 Methylenetetrahydrofolate reductase MTHFR 0.0004
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0004
3405 Quinohaemoprotein ethanol dehydrogenase type-1 qheDH 0.0004
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0004
936 Ephrin type-A receptor 2 EPHA2 0.0004
6042 Prostaglandin reductase 2 PTGR2 0.0004
6163 Copper-transporting ATPase 2 ATP7B 0.0004
6165 Copper-transporting ATPase 1 ATP7A 0.0004
1360 Sphingomyelin phosphodiesterase SMPD1 0.0004
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0004
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0004
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0004
1792 Tissue-type plasminogen activator PLAT 0.0004
162 Retinoic acid receptor gamma-1 RARG 0.0004
6043 Putative G-protein coupled receptor 44 GPR44 0.0004
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0004
908 Glutathione S-transferase theta-1 GSTT1 0.0004
284 DNA-directed RNA polymerase beta chain rpoB 0.0004
5773 DNA-directed RNA polymerase beta chain rpoB 0.0004
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0004
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0004
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0004
6168 Solute carrier family 22 member 16 SLC22A16 0.0003
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0003
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0003
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0003
896 Glutathione S-transferase Mu 1 GSTM1 0.0003
1313 Lactoylglutathione lyase GLO1 0.0003
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0003
76 Nitric-oxide synthase, brain NOS1 0.0003
489 Monocarboxylate transporter 2 SLC16A7 0.0003
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0003
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0003
4954 Soluble cytochrome b558 Not Available 0.0002
4916 Cyanoglobin glbN 0.0002
4934 Cytochrome c-551 nirM 0.0002
5218 Cytochrome c-551 nirM 0.0002
4947 Bacterial hemoglobin vhb 0.0002
4915 Cytochrome c-550 psbV 0.0002
4959 Cytochrome c-550 psbV 0.0002
5216 Cytochrome c-550 psbV 0.0002
4925 Cytochrome c-type protein SHP shp 0.0002
4998 Hemoglobin-like protein yjbI yjbI 0.0002
4905 Cytochrome c2 Not Available 0.0002
4939 Cytochrome c2 cycA 0.0002
4964 Cytochrome c2 cycA 0.0002
4979 Cytochrome c2 cycA 0.0002
6673 Cytochrome c2 cycA 0.0002
5000 HemO hemO 0.0002
4975 Cytochrome c-556 RPA3973 0.0002
4984 Neuroglobin NGB 0.0002
4943 Cytochrome c6 petJ 0.0002
4910 Cytoglobin CYGB 0.0002
4907 Cytochrome c-L moxG 0.0002
6865 Cytochrome c-L moxG 0.0002
4981 Iron-starvation protein PigA pigA 0.0002
4971 Nonaheme cytochrome c hmcA 0.0002
4936 Cytochrome c2 iso-2 Not Available 0.0002
4909 CooA protein cooA 0.0002
4994 Hemoglobin-like protein HbO glbO 0.0002
4935 Cytochrome c-554 cycA1 0.0002
644 Heme oxygenase 2 HMOX2 0.0002
4982 Heme oxygenase 2 pbsA2 0.0002
4942 Diheme cytochrome c napB napB 0.0002
3116 Bacterioferritin bfr 0.0002
4906 Bacterioferritin bfr 0.0002
4965 Bacterioferritin bfr 0.0002
4922 Cytochrome c, putative SO_4144 0.0002
4764 Cytochrome P450 165C4 CYP165C4 0.0002
4937 Cytochrome oxidase subunit II rcoxA 0.0002
4989 Cytochrome c551 peroxidase ccp 0.0002
5222 Cytochrome c551 peroxidase ccpA 0.0002
4961 Hemophore HasA hasA 0.0002
4976 Apocytochrome f petA 0.0002
6407 Apocytochrome f petA 0.0002
4904 Cytochrome c family protein GSU1996 0.0002
4903 Methyl-accepting chemotaxis protein Tar4 0.0002
4999 Cytochrome P450 165B3 CYP165B3 0.0002
4960 Putative cytochrome P450-family protein SCO7417 0.0002
4931 Cytochrome P450 167A1 CYP167A1 0.0002
4926 Heme-based aerotactic transducer hemAT hemAT 0.0002
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0002
4993 Hydroxylamine oxidoreductase hao1 0.0002
4972 P450cin cinA 0.0002
3093 Catalase HPII katE 0.0002
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0002
4952 Catalase/peroxidase katA 0.0002
4920 Peroxidase/catalase katG 0.0001
2119 Cytochrome b5 CYB5A 0.0001
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0001
4990 PpcA ppcA 0.0001
4988 Sulfite oxidase, mitochondrial SUOX 0.0001
3375 Acidic cytochrome c3 Not Available 0.0001
2915 Sensor protein fixL fixL 0.0001
4944 Sensor protein fixL fixL 0.0001
4037 Hypothetical protein GPX1 0.0001
4297 Hypothetical protein SP_1951 0.0001
4521 Hypothetical protein BC_2969 0.0001
4540 Hypothetical protein TM_1070 0.0001
4555 Hypothetical protein MT1739 0.0001
4569 Hypothetical protein mshD 0.0001
4578 Hypothetical protein PA3270 0.0001
4747 Hypothetical protein PA3967 0.0001
5177 Hypothetical protein TM_0096 0.0001
5194 Hypothetical protein PA1204 0.0001
5240 Hypothetical protein Rv2991 0.0001
5370 Hypothetical protein TM_1158 0.0001
5710 Hypothetical protein Tb927.5.1360 0.0001
3570 Cytochrome P450 152A1 cypC 0.0001
4385 Cytochrome c' Not Available 0.0001
4967 Cytochrome c' cycA 0.0001
5038 Cytochrome c' Not Available 0.0001
5223 Cytochrome c' cycP 0.0001
4813 Heme oxygenase hmuO 0.0001
5769 Heme oxygenase Not Available 0.0001
4992 Cytochrome c peroxidase Not Available 0.0001
4289 Cytochrome P450 TT_P0059 0.0001
6262 Cytochrome P450 staP 0.0001
2230 Catalase CAT 0.0001
3249 Catalase katA 0.0001
3625 Catalase katA 0.0001
4539 Catalase katA 0.0001
4941 Catalase katB 0.0001
3670 Soluble cytochrome b562 precursor cybC 0.0001
3411 Cytochrome P450 121 cyp121 0.0001
3291 Cytochrome c-552 cycA 0.0001
4927 Cytochrome c-552 nrfA 0.0001
4938 Cytochrome c-552 cycA 0.0001
4953 Cytochrome c-552 nrfA 0.0001
5217 Cytochrome c-552 cycM 0.0001
2617 Nitric oxide synthase oxygenase nos 0.0001
2701 Nitric oxide synthase oxygenase nos 0.0001
3102 Flavohemoprotein hmp 0.0001
4969 Flavohemoprotein hmp 0.0001
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0001
605 Fumarate reductase flavoprotein subunit frdA 0.0001
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0001
3673 Fumarate reductase flavoprotein subunit fccA 0.0001
4912 Fumarate reductase flavoprotein subunit ifcA 0.0001
6549 Fumarate reductase flavoprotein subunit frdA 0.0001
2972 6-deoxyerythronolide B hydroxylase eryF 0.0001
4608 Putative cytochrome P450 SCO1207 0.0001
4963 Putative cytochrome P450 SCO2884 0.0001
6254 Putative cytochrome P450 SCO6998 0.0001
358 Cystathionine beta-synthase CBS 0.0001
693 Hemoglobin subunit beta HBB 0.0001
6268 Hydroxyacid oxidase 1 HAO1 0.0001
810 Heme oxygenase 1 HMOX1 0.0001
3391 Heme oxygenase 1 pbsA1 0.0001
2298 Cytochrome P450-cam camC 0.0001
↑