DT-Web

DB00604 - Cisapride


Identification
Name Cisapride
Accession Number DB00604 (APRD00454)
Type small molecule
Description In many countries (including Canada) cisapride has been either withdrawn or has had its indications limited due to reports about long QT syndrome due to cisapride, which predisposes to arrhythmias. The FDA issued a warning letter regarding this risk to health care professionals and patients.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 465.945
Groups approved
Monoisotopic Weight 465.183062343
Pharmacology
Indication For the symptomatic treatment of adult patients with nocturnal heartburn due to gastroesophageal reflux disease.
Mechanism of action Cisapride acts through the stimulation of the serotonin 5-HT4 receptors which increases acetylcholine release in the enteric nervous system (specifically the myenteric plexus). This results in increased tone and amplitude of gastric (especially antral) contractions, relaxation of the pyloric sphincter and the duodenal bulb, and increased peristalsis of the duodenum and jejunum resulting in accelerated gastric emptying and intestinal transit.
Absorption Cisapride is rapidly absorbed after oral administration, with an absolute bioavailability of 35-40%.
Protein binding 97.5%
Biotransformation Hepatic. Extensively metabolized via cytochrome P450 3A4 enzyme.
Route of elimination Not Available
Toxicity Not Available
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Acenocoumarol Cisapride may increase the anticoagulant effect of acenocoumarol.
Acetophenazine Increased risk of cardiotoxicity and arrhythmias
Amiodarone Increased risk of cardiotoxicity and arrhythmias
Amitriptyline Increased risk of cardiotoxicity and arrhythmias
Amoxapine Increased risk of cardiotoxicity and arrhythmias
Amprenavir Amprenavir may increase the effect and toxicity of cisapride.
Anisindione Cisapride may increase the anticoagulant effect of anisindione.
Aprepitant Increased risk of cardiotoxicity and arrhythmias
Artemether Additive QTc-prolongation may occur. Concomitant therapy should be avoided.
Astemizole Increased risk of cardiotoxicity and arrhythmias
Atazanavir Increased risk of cardiotoxicity and arrhythmias
Bepridil Increased risk of cardiotoxicity and arrhythmias
Boceprevir Boceprevir increases levels by affecting CYP3A4 metabolism. Concomitant therapy is contraindicated.
Bretylium Increased risk of cardiotoxicity and arrhythmias
Chlorpromazine Increased risk of cardiotoxicity and arrhythmias
Clarithromycin Increased risk of cardiotoxicity and arrhythmias
Clomipramine Increased risk of cardiotoxicity and arrhythmias
Crizotinib Concurrent use with drugs that prolong QTc interval is contraindicated.
Delavirdine Delavirdine, a strong CYP3A4 inhibitor, may increase the metabolism of cisapride. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of cisapride if delavirdine is initiated, discontinued or dose changed.
Desipramine Increased risk of cardiotoxicity and arrhythmias
Dicumarol Cisapride may increase the anticoagulant effect of dicumarol.
Dihydroquinidine barbiturate Increased risk of cardiotoxicity and arrhythmias
Diltiazem Diltiazem, a moderate CYP3A4 inhibitor, may increase the serum concentration of cisapride by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of cisapride if diltiazem is initiated, discontinued or dose changed.
Disopyramide Increased risk of cardiotoxicity and arrhythmias
Doxepin Increased risk of cardiotoxicity and arrhythmias
Efavirenz Increased risk of cardiotoxicity and arrhythmias
Encainide Increased risk of cardiotoxicity and arrhythmias
Erythromycin Increased risk of cardiotoxicity and arrhythmias
Ethopropazine Increased risk of cardiotoxicity and arrhythmias
Fexofenadine Increased risk of cardiotoxicity and arrhythmias
Flecainide Increased risk of cardiotoxicity and arrhythmias
Fluconazole Increased risk of cardiotoxicity and arrhythmias
Fluphenazine Increased risk of cardiotoxicity and arrhythmias
Fosamprenavir Amprenavir increases the effect and toxicity of cisapride
Ibutilide Increased risk of cardiotoxicity and arrhythmias
Imipramine Increased risk of cardiotoxicity and arrhythmias
Indinavir Increased risk of cardiotoxicity and arrhythmias
Itraconazole Increased risk of cardiotoxicity and arrhythmias
Josamycin Increased risk of cardiotoxicity and arrhythmias
Ketoconazole Increased risk of cardiotoxicity and arrhythmias
Lumefantrine Additive QTc-prolongation may occur. Concomitant therapy should be avoided.
Maprotiline Increased risk of cardiotoxicity and arrhythmias
Mesoridazine Increased risk of cardiotoxicity and arrhythmias
Methdilazine Increased risk of cardiotoxicity and arrhythmias
Methotrimeprazine Increased risk of cardiotoxicity and arrhythmias
Mibefradil Mibefradil increases levels of cisapride
Nefazodone Nefazodone increases serum levels of cisapride
Nelfinavir Increased risk of cardiotoxicity and arrhythmias
Nifedipine Cisapride may increase the effect and toxicity of nifedipine.
Nortriptyline Increased risk of cardiotoxicity and arrhythmias
Perphenazine Increased risk of cardiotoxicity and arrhythmias
Posaconazole Contraindicated co-administration
Procainamide Increased risk of cardiotoxicity and arrhythmias
Prochlorperazine Increased risk of cardiotoxicity and arrhythmias
Promazine Increased risk of cardiotoxicity and arrhythmias
Promethazine Increased risk of cardiotoxicity and arrhythmias
Propafenone Increased risk of cardiotoxicity and arrhythmias
Propiomazine Increased risk of cardiotoxicity and arrhythmias
Protriptyline Increased risk of cardiotoxicity and arrhythmias
Quinidine Increased risk of cardiotoxicity and arrhythmias
Quinidine barbiturate Increased risk of cardiotoxicity and arrhythmias
Quinupristin This combination presents an increased risk of toxicity
Ritonavir Increased risk of cardiotoxicity and arrhythmias
Saquinavir Increased risk of cardiotoxicity and arrhythmias
Sotalol Increased risk of cardiotoxicity and arrhythmias
Tacrolimus Additive QTc-prolongation may occur increasing the risk of serious ventricular arrhythmias. Concomitant therapy should be used with caution. Cisapride may also increase the concentration of Tacrolimus in the blood.
Telaprevir Telaprevir increases levels by affecting CYP3A4 metabolism. Concomitant therapy is contraindicated.
Telavancin Additive QTc-prolongation may occur. Concomitant therapy should be avoided.
Telithromycin Telithromycin may reduce clearance of Cisapride. Concomitant therapy is contraindicated.
Terfenadine Increased risk of cardiotoxicity and arrhythmias
Thiethylperazine Increased risk of cardiotoxicity and arrhythmias
Thioridazine Increased risk of cardiotoxicity and arrhythmias
Thiothixene May cause additive QTc-prolonging effects. Increased risk of ventricular arrhythmias. Consider alternate therapy. Thorough risk:benefit assessment is required prior to co-administration.
Tipranavir Tipranavir, co-administered with Ritonavir, may increase the plasma concentration of Cisapride. Concomitant therapy is contraindicated.
Toremifene Additive QTc-prolongation may occur, increasing the risk of serious ventricular arrhythmias. Consider alternate therapy. A thorough risk:benefit assessment is required prior to co-administration.
Trifluoperazine Increased risk of cardiotoxicity and arrhythmias
Triflupromazine Increased risk of cardiotoxicity and arrhythmias
Trimeprazine Increased risk of cardiotoxicity and arrhythmias
Trimipramine Additive QTc-prolongation may occur, increasing the risk of serious ventricular arrhythmias. Concomitant therapy should be used with caution.
Troleandomycin Increased risk of cardiotoxicity and arrhythmias
Voriconazole Voriconazole may increase the serum concentration and toxicity of cisapride likely by decreasing its metabolism. Additive QTc prolongation may also occur. Concomitant therapy is contraindicated.
Vorinostat Additive QTc prolongation may occur. Consider alternate therapy or monitor for QTc prolongation as this can lead to Torsade de Pointes (TdP).
Warfarin Cisapride may increase the anticoagulant effect of warfarin.
Zafirlukast Increased risk of cardiotoxicity and arrhythmias
Ziprasidone Additive QTc-prolonging effects may increase the risk of severe arrhythmias. Concomitant therapy should be avoided.
Zuclopenthixol Additive QTc prolongation may occur. Consider alternate therapy or use caution and monitor for QTc prolongation as this can lead to Torsade de Pointes (TdP).
Food Interactions
  • Grapefruit and grapefruit juice should be avoided throughout treatment, grapefruit can significantly increase serum levels of this product.
  • Increases absorption, take 30 minutes before a meal.

Targets


5-hydroxytryptamine 4 receptor
Name 5-hydroxytryptamine 4 receptor
Gene Name HTR4
Pharmacological action yes
Actions agonist
References
  • Crema F, Modini C, Croci T, Langlois M, de Ponti F: Intestinal prokinesia by two esters of 4-amino-5-chloro-2- methoxybenzoic acid: involvement of 5-hydroxytryptamine-4 receptors and dissociation from cardiac effects in vivo. J Pharmacol Exp Ther. 1999 Mar;288(3):1045-52. - Pubmed
  • Nagakura Y, Akuzawa S, Miyata K, Kamato T, Suzuki T, Ito H, Yamaguchi T: Pharmacological properties of a novel gastrointestinal prokinetic benzamide selective for human 5-HT4 receptor versus human 5-HT3 receptor. Pharmacol Res. 1999 May;39(5):375-82. - Pubmed
  • Rahme MM, Cotter B, Leistad E, Wadhwa MK, Mohabir R, Ford AP, Eglen RM, Feld GK: Electrophysiological and antiarrhythmic effects of the atrial selective 5-HT(4) receptor antagonist RS-100302 in experimental atrial flutter and fibrillation. Circulation. 1999 Nov 9;100(19):2010-7. - Pubmed
  • Bharucha AE, Camilleri M, Haydock S, Ferber I, Burton D, Cooper S, Tompson D, Fitzpatrick K, Higgins R, Zinsmeister AR: Effects of a serotonin 5-HT(4) receptor antagonist SB-207266 on gastrointestinal motor and sensory function in humans. Gut. 2000 Nov;47(5):667-74. - Pubmed
  • Bach T, Syversveen T, Kvingedal AM, Krobert KA, Brattelid T, Kaumann AJ, Levy FO: 5HT4(a) and 5-HT4(b) receptors have nearly identical pharmacology and are both expressed in human atrium and ventricle. Naunyn Schmiedebergs Arch Pharmacol. 2001 Feb;363(2):146-60. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score 0.2798
5-hydroxytryptamine 3 receptor
Name 5-hydroxytryptamine 3 receptor
Gene Name HTR3A
Pharmacological action yes
Actions agonist
References
  • Nagakura Y, Akuzawa S, Miyata K, Kamato T, Suzuki T, Ito H, Yamaguchi T: Pharmacological properties of a novel gastrointestinal prokinetic benzamide selective for human 5-HT4 receptor versus human 5-HT3 receptor. Pharmacol Res. 1999 May;39(5):375-82. - Pubmed
  • Talley NJ: Review article: 5-hydroxytryptamine agonists and antagonists in the modulation of gastrointestinal motility and sensation: clinical implications. Aliment Pharmacol Ther. 1992 Jun;6(3):273-89. - Pubmed
  • de Ridder WJ, Schuurkes JA: Cisapride and 5-hydroxytryptamine enhance motility in the canine antrum via separate pathways, not involving 5-hydroxytryptamine1,2,3,4 receptors. J Pharmacol Exp Ther. 1993 Jan;264(1):79-88. - Pubmed
  • Haga N, Suzuki H, Shiba Y, Mochiki E, Mizumoto A, Itoh Z: Effect of TKS159, a novel 5-hydroxytryptamine4 agonist, on gastric contractile activity in conscious dogs. Neurogastroenterol Motil. 1998 Aug;10(4):295-303. - Pubmed
DTHybrid score 0.26
5-hydroxytryptamine 2A receptor
Name 5-hydroxytryptamine 2A receptor
Gene Name HTR2A
Pharmacological action yes
Actions agonist
References
  • Nieto JE, Snyder JR, Kollias-Baker C, Stanley S: In vitro effects of 5-hydroxytryptamine and cisapride on the circular smooth muscle of the jejunum of horses. Am J Vet Res. 2000 Dec;61(12):1561-5. - Pubmed
  • Cushing DJ, Cohen ML: Serotonin-induced contraction in porcine coronary artery: use of ergolines to support vascular 5-hydroxytryptamine2-receptor heterogeneity. J Pharmacol Exp Ther. 1993 Jan;264(1):193-200. - Pubmed
  • Beubler E, Coupar IM, Hardcastle J, Hardcastle PT: Stimulatory effects of 5-hydroxytryptamine on fluid secretion and transmural potential difference in rat small intestine are mediated by different receptor subtypes. J Pharm Pharmacol. 1990 Jan;42(1):35-9. - Pubmed
DTHybrid score 0.3226
Potassium voltage-gated channel subfamily H member 2
Name Potassium voltage-gated channel subfamily H member 2
Gene Name KCNH2
Pharmacological action unknown
Actions inhibitor
References
  • Walker BD, Singleton CB, Bursill JA, Wyse KR, Valenzuela SM, Qiu MR, Breit SN, Campbell TJ: Inhibition of the human ether-a-go-go-related gene (HERG) potassium channel by cisapride: affinity for open and inactivated states. Br J Pharmacol. 1999 Sep;128(2):444-50. - Pubmed
  • Chen J, Seebohm G, Sanguinetti MC: Position of aromatic residues in the S6 domain, not inactivation, dictates cisapride sensitivity of HERG and eag potassium channels. Proc Natl Acad Sci U S A. 2002 Sep 17;99(19):12461-6. Epub 2002 Sep 3. - Pubmed
  • Lin J, Guo J, Gang H, Wojciechowski P, Wigle JT, Zhang S: Intracellular K+ is required for the inactivation-induced high-affinity binding of cisapride to HERG channels. Mol Pharmacol. 2005 Sep;68(3):855-65. Epub 2005 Jun 20. - Pubmed
  • Perrio M, Voss S, Shakir SA: Application of the bradford hill criteria to assess the causality of cisapride-induced arrhythmia: a model for assessing causal association in pharmacovigilance. Drug Saf. 2007;30(4):333-46. - Pubmed
  • Mohammad S, Zhou Z, Gong Q, January CT: Blockage of the HERG human cardiac K+ channel by the gastrointestinal prokinetic agent cisapride. Am J Physiol. 1997 Nov;273(5 Pt 2):H2534-8. - Pubmed
DTHybrid score 0.2351

Enzymes


Cytochrome P450 3A7
Name Cytochrome P450 3A7
Gene Name CYP3A7
Actions substrate
References
  • Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.4352
Cytochrome P450 3A4
Name Cytochrome P450 3A4
Gene Name CYP3A4
Actions substrate,inhibitor
References
  • Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
  • Pearce RE, Gotschall RR, Kearns GL, Leeder JS: Cytochrome P450 Involvement in the biotransformation of cisapride and racemic norcisapride in vitro: differential activity of individual human CYP3A isoforms. Drug Metab Dispos. 2001 Dec;29(12):1548-54. - Pubmed
DTHybrid score 1.0036
Cytochrome P450 3A5
Name Cytochrome P450 3A5
Gene Name CYP3A5
Actions substrate
References
  • Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.5495
Cytochrome P450 1A2
Name Cytochrome P450 1A2
Gene Name CYP1A2
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.6463
Cytochrome P450 2A6
Name Cytochrome P450 2A6
Gene Name CYP2A6
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.3895
Cytochrome P450 2B6
Name Cytochrome P450 2B6
Gene Name CYP2B6
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.446
Cytochrome P450 2C19
Name Cytochrome P450 2C19
Gene Name CYP2C19
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.6087
Cytochrome P450 2C8
Name Cytochrome P450 2C8
Gene Name CYP2C8
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.5176
Cytochrome P450 2C9
Name Cytochrome P450 2C9
Gene Name CYP2C9
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.7354
Cytochrome P450 2D6
Name Cytochrome P450 2D6
Gene Name CYP2D6
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.8037

Predictions


Id Partner name Gene Name Score
1588 Multidrug resistance protein 1 ABCB1 0.4182
6013 Cytochrome P450 2E1 CYP2E1 0.3009
6024 Cytochrome P450 1A1 CYP1A1 0.2102
831 D(2) dopamine receptor DRD2 0.1809
320 5-hydroxytryptamine 1A receptor HTR1A 0.1672
492 Histamine H1 receptor HRH1 0.1456
587 Serum albumin ALB 0.1409
590 5-hydroxytryptamine 2C receptor HTR2C 0.1331
20 Prostaglandin G/H synthase 1 PTGS1 0.133
556 Alpha-1A adrenergic receptor ADRA1A 0.1277
824 Sodium-dependent serotonin transporter SLC6A4 0.1275
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.122
6106 Cytochrome P450 2C18 CYP2C18 0.1098
103 Muscarinic acetylcholine receptor M1 CHRM1 0.1012
23 D(1A) dopamine receptor DRD1 0.1002
6145 Solute carrier family 22 member 1 SLC22A1 0.0977
632 Alpha-1B adrenergic receptor ADRA1B 0.0958
318 Alpha-2A adrenergic receptor ADRA2A 0.0955
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0944
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0903
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0896
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0891
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0858
713 Sodium-dependent dopamine transporter SLC6A3 0.0794
847 Mu-type opioid receptor OPRM1 0.0789
6144 Solute carrier family 22 member 2 SLC22A2 0.078
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0769
638 D(3) dopamine receptor DRD3 0.0767
3811 Cytochrome P450 19A1 CYP19A1 0.0745
885 5-hydroxytryptamine 1B receptor HTR1B 0.0739
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0736
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0736
862 Multidrug resistance-associated protein 1 ABCC1 0.0713
766 Beta-2 adrenergic receptor ADRB2 0.0705
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0655
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0654
1898 Cytochrome P450 1B1 CYP1B1 0.0631
1729 Solute carrier family 22 member 6 SLC22A6 0.0629
789 Alpha-1D adrenergic receptor ADRA1D 0.062
193 Beta-1 adrenergic receptor ADRB1 0.0611
436 5-hydroxytryptamine 2B receptor HTR2B 0.06
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0599
290 Prostaglandin G/H synthase 2 PTGS2 0.0594
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0593
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0581
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0574
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.057
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0565
629 Alpha-2B adrenergic receptor ADRA2B 0.0557
378 Alpha-2C adrenergic receptor ADRA2C 0.0554
432 D(4) dopamine receptor DRD4 0.0547
696 Kappa-type opioid receptor OPRK1 0.0539
776 Bile salt export pump ABCB11 0.0537
716 5-hydroxytryptamine 7 receptor HTR7 0.053
725 5-hydroxytryptamine 1D receptor HTR1D 0.0522
118 Organic cation/carnitine transporter 2 SLC22A5 0.0495
467 Delta-type opioid receptor OPRD1 0.0493
380 Cytochrome P450 17A1 CYP17A1 0.0489
6031 Cytochrome P450 3A43 CYP3A43 0.0485
1256 5-hydroxytryptamine 6 receptor HTR6 0.048
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.048
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0477
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0476
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0462
3941 Amine oxidase [flavin-containing] A MAOA 0.0461
817 DNA topoisomerase 2-alpha TOP2A 0.045
731 HIV-1 protease HIV-1 protease 0.0438
6182 Cytochrome P450 2J2 CYP2J2 0.0436
260 Cytochrome P450 51 ERG11 0.0432
761 Cytochrome P450 51 ERG11 0.0432
3163 Cytochrome P450 51 cyp51 0.0432
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0431
136 Estrogen receptor ESR1 0.043
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0426
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0422
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0412
465 Calmodulin CALM1 0.0411
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0409
871 Glucocorticoid receptor NR3C1 0.0408
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0403
468 Cytochrome P450 4A11 CYP4A11 0.0387
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0387
2164 Multidrug resistance-associated protein 4 ABCC4 0.0383
3923 Cholinesterase BCHE 0.0383
6143 Solute carrier family 22 member 7 SLC22A7 0.0382
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0382
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.038
6147 Solute carrier family 22 member 3 SLC22A3 0.038
163 D(1B) dopamine receptor DRD5 0.0378
6142 Solute carrier family 22 member 8 SLC22A8 0.0371
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0364
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0361
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0351
3939 Amine oxidase [flavin-containing] B MAOB 0.0344
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0339
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0335
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0331
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0323
833 Organic cation/carnitine transporter 1 SLC22A4 0.0317
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0315
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0305
528 5-hydroxytryptamine 1E receptor HTR1E 0.0285
233 Potassium channel subfamily K member 2 KCNK2 0.0285
174 Sigma 1-type opioid receptor SIGMAR1 0.0283
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0278
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0272
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0272
1968 ATP-sensitive inward rectifier potassium channel 12 KCNJ12 0.027
122 P2Y purinoceptor 12 P2RY12 0.027
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0269
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0269
474 Acetylcholinesterase ACHE 0.0267
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0259
36 Insulin receptor INSR 0.0258
891 Dihydropteroate synthase folP 0.0251
5359 Dihydropteroate synthase folP 0.0251
7175 Dihydropteroate synthase sulI 0.0251
6014 Cytochrome P450 2A13 CYP2A13 0.0245
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0235
146 Androgen receptor AR 0.0234
6148 Multidrug resistance-associated protein 7 ABCC10 0.0234
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0232
614 Progesterone receptor PGR 0.0232
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0231
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0229
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0225
811 Translocator protein TSPO 0.0224
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0222
477 DNA topoisomerase 4 subunit A parC 0.0221
886 DNA topoisomerase 4 subunit A parC 0.0221
6226 DNA topoisomerase 4 subunit A parC 0.0221
404 DNA gyrase subunit A gyrA 0.0217
6224 DNA gyrase subunit A gyrA 0.0217
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0213
504 Mast/stem cell growth factor receptor KIT 0.0211
6102 Arylamine N-acetyltransferase 2 NAT2 0.0208
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0206
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0205
6136 Multidrug resistance-associated protein 5 ABCC5 0.0205
6220 Aryl hydrocarbon receptor AHR 0.0204
844 Epidermal growth factor receptor EGFR 0.0203
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0202
124 Histamine H2 receptor HRH2 0.0201
737 Mineralocorticoid receptor NR3C2 0.0198
131 Synaptic vesicular amine transporter SLC18A2 0.0196
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0194
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0191
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0189
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0189
232 Corticosteroid-binding globulin SERPINA6 0.0188
3086 Plasmepsin-2 Not Available 0.0188
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0187
756 Sex hormone-binding globulin SHBG 0.0184
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0183
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0183
1024 Solute carrier family 22 member 11 SLC22A11 0.0182
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.018
1010 Cytochrome P450 51A1 CYP51A1 0.018
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0179
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0178
70 Type-1 angiotensin II receptor AGTR1 0.0178
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0178
4604 Liver carboxylesterase 1 CES1 0.0177
1656 CYP2B protein CYP2B 0.0176
921 Glutamate receptor 2 GRIA2 0.0174
4120 NADPH--cytochrome P450 reductase POR 0.0174
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0174
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0172
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0172
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0172
818 50S ribosomal protein L10 rplJ 0.0171
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0171
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0171
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0171
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0168
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0168
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0168
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0168
407 Vascular endothelial growth factor receptor 2 KDR 0.0167
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0166
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0166
26 Vascular endothelial growth factor receptor 3 FLT4 0.0166
751 Potassium channel subfamily K member 6 KCNK6 0.0165
777 Tumor necrosis factor TNF 0.0163
705 Glutamate receptor 1 GRIA1 0.0163
427 Substance-P receptor TACR1 0.0159
4148 Serine/threonine-protein kinase mTOR MTOR 0.0159
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0158
869 Estrogen receptor beta ESR2 0.0158
32 Vascular endothelial growth factor receptor 1 FLT1 0.0158
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0158
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0157
228 Beta platelet-derived growth factor receptor PDGFRB 0.0157
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0156
482 Glycine receptor subunit alpha-1 GLRA1 0.0156
6137 Multidrug resistance-associated protein 6 ABCC6 0.0155
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0152
6141 Sodium/bile acid cotransporter SLC10A1 0.0151
172 Potassium channel subfamily K member 1 KCNK1 0.015
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0147
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0143
6020 Aldehyde oxidase AOX1 0.0142
1757 Myeloperoxidase MPO 0.0142
29 Tubulin beta-1 chain TUBB1 0.0142
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0139
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0138
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0135
3947 Xanthine dehydrogenase/oxidase XDH 0.0135
4237 50S ribosomal protein L22 rplV 0.0133
161 Tubulin beta chain TUBB 0.0133
312 Tubulin beta chain TUB2 0.0133
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0132
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0132
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0132
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.013
16 Adenosine A1 receptor ADORA1 0.0129
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0127
596 3-oxo-5-alpha-steroid 4-dehydrogenase 1 SRD5A1 0.0126
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0125
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0125
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0124
4238 50S ribosomal protein L4 rplD 0.0124
5578 50S ribosomal protein L4 rplD 0.0124
6173 50S ribosomal protein L4 rplD 0.0124
6219 50S ribosomal protein L4 rplD 0.0124
1178 Adenosine A2a receptor ADORA2A 0.0123
537 ATP synthase delta chain, mitochondrial ATP5D 0.0122
571 Melatonin receptor type 1A MTNR1A 0.0122
362 Melatonin receptor type 1B MTNR1B 0.0122
275 Arachidonate 5-lipoxygenase ALOX5 0.0122
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0121
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0121
6432 Transporter snf 0.012
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.012
952 Dipeptidyl peptidase 4 DPP4 0.0119
295 Carbonic anhydrase 1 CA1 0.0118
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0117
365 Dihydrofolate reductase DHFR 0.0115
2381 Dihydrofolate reductase DFR1 0.0115
2833 Dihydrofolate reductase Not Available 0.0115
2931 Dihydrofolate reductase folA 0.0115
3544 Dihydrofolate reductase folA 0.0115
3682 Dihydrofolate reductase folA 0.0115
6642 Dihydrofolate reductase folA 0.0115
6756 Dihydrofolate reductase dfrA 0.0115
642 3-oxo-5-alpha-steroid 4-dehydrogenase 2 SRD5A2 0.0115
373 Transthyretin TTR 0.0115
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0114
84 Nuclear receptor 0B1 NR0B1 0.011
208 DNA-directed RNA polymerase beta' chain rpoC 0.0109
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0109
183 Vascular endothelial growth factor A VEGFA 0.0108
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0107
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0106
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0105
3932 Glutathione S-transferase A2 GSTA2 0.0103
518 Peroxidase/catalase T katG 0.0102
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0102
273 Apoptosis regulator Bcl-2 BCL2 0.0101
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0101
4122 Histone deacetylase 2 HDAC2 0.0101
1050 Bile salt sulfotransferase SULT2A1 0.0101
738 Monocarboxylate transporter 1 SLC16A1 0.0099
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0099
1618 High affinity nerve growth factor receptor NTRK1 0.0098
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0098
4116 Dihydropteroate synthetase Not Available 0.0097
88 Retinoic acid receptor RXR-beta RXRB 0.0097
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0097
958 Insulin-like growth factor 1 receptor IGF1R 0.0097
563 Thyroid peroxidase TPO 0.0097
592 Carbonic anhydrase 4 CA4 0.0097
1192 Sulfotransferase 1A1 SULT1A1 0.0096
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0096
49 Endothelin B receptor EDNRB 0.0096
2539 Tubulin alpha-1 chain TUBA4A 0.0095
6085 Fatty acid-binding protein, intestinal FABP2 0.0094
165 FL cytokine receptor FLT3 0.0093
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0093
469 Annexin A1 ANXA1 0.0093
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0092
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0092
6174 50S ribosomal protein L32 rpmF 0.0091
578 Endothelin-1 receptor EDNRA 0.009
5251 Carbonyl reductase [NADPH] 1 CBR1 0.009
3810 Catechol O-methyltransferase COMT 0.009
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.009
284 DNA-directed RNA polymerase beta chain rpoB 0.0089
5773 DNA-directed RNA polymerase beta chain rpoB 0.0089
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.0088
68 Cannabinoid receptor 1 CNR1 0.0087
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0087
823 Fibroblast growth factor receptor 2 FGFR2 0.0086
4203 Histamine N-methyltransferase HNMT 0.0086
2112 Toll-like receptor 9 TLR9 0.0086
7 Nitric oxide synthase, inducible NOS2 0.0084
814 Ryanodine receptor 1 RYR1 0.0084
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0084
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0084
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0084
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0084
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0084
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0084
780 Retinoic acid receptor RXR-gamma RXRG 0.0083
768 FK506-binding protein 1A FKBP1A 0.0083
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0083
239 Coagulation factor X F10 0.0082
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0082
251 Alcohol dehydrogenase 1A ADH1A 0.0081
1374 Natriuretic peptides B NPPB 0.008
565 Extracellular calcium-sensing receptor CASR 0.008
1827 Gap junction alpha-1 protein GJA1 0.008
1908 Vascular cell adhesion protein 1 VCAM1 0.008
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.008
5300 Antigen peptide transporter 1 TAP1 0.008
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.008
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.008
1196 Complement decay-accelerating factor CD55 0.008
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.008
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0079
164 Histamine H4 receptor HRH4 0.0079
511 5-hydroxytryptamine 1F receptor HTR1F 0.0079
173 Toll-like receptor 7 TLR7 0.0079
442 Envelope glycoprotein gp41 0.0078
4859 Envelope glycoprotein env 0.0078
723 Cytosolic phospholipase A2 PLA2G4A 0.0077
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0077
6044 Serum paraoxonase/lactonase 3 PON3 0.0076
319 Opioid receptor, sigma 1 OPRS1 0.0076
923 Glutamate receptor 3 GRIA3 0.0075
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0075
3809 Estrogen-related receptor gamma ESRRG 0.0075
4311 tRNA TRDMT1 0.0074
4325 tRNA trmD 0.0074
4328 tRNA trmD 0.0074
1541 Metalloproteinase mmp20 0.0074
1517 Beta-3 adrenergic receptor ADRB3 0.0074
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0073
54 Prothrombin F2 0.0073
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0073
1630 Integrin beta-2 ITGB2 0.0073
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0072
2183 Fatty acid-binding protein, adipocyte FABP4 0.0072
357 Carbonic anhydrase 2 CA2 0.0072
444 Alcohol dehydrogenase 1B ADH1B 0.0072
904 Glutathione S-transferase P GSTP1 0.0072
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0072
162 Retinoic acid receptor gamma-1 RARG 0.0072
2230 Catalase CAT 0.0071
3249 Catalase katA 0.0071
3625 Catalase katA 0.0071
4539 Catalase katA 0.0071
4941 Catalase katB 0.0071
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0071
856 Vitamin D3 receptor VDR 0.0071
24 Thymidylate synthase TMP1 0.0071
359 Thymidylate synthase TYMS 0.0071
2626 Thymidylate synthase thyA 0.0071
2729 Thymidylate synthase thyA 0.0071
5352 Thymidylate synthase THYA 0.0071
2808 Chloramphenicol acetyltransferase 3 cat3 0.0069
1275 Estrogen sulfotransferase SULT1E1 0.0069
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0069
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0069
1629 Transcription factor AP-1 JUN 0.0068
1483 Membrane copper amine oxidase AOC3 0.0067
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0067
976 Platelet glycoprotein IX GP9 0.0067
1636 Trace amine-associated receptor 1 TAAR1 0.0067
153 Dopamine beta-hydroxylase DBH 0.0067
5934 Cytochrome P450 26A1 CYP26A1 0.0066
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0066
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0066
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0066
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0066
719 Retinoic acid receptor responder protein 1 RARRES1 0.0066
770 Retinoic acid-induced protein 3 GPRC5A 0.0066
1852 Microtubule-associated protein 2 MAP2 0.0065
581 Cytochrome P450 2R1 CYP2R1 0.0065
3601 Dihydropteroate synthase 1 folP1 0.0063
3807 Dihydropteroate synthase 1 folP1 0.0063
3808 Dihydropteroate synthase 2 folP2 0.0063
2417 Chloramphenicol acetyltransferase cat 0.0063
3278 Chloramphenicol acetyltransferase cat 0.0063
1648 Elastin ELN 0.0063
133 Dihydropterate synthase sulI 0.0063
982 Cocaine- and amphetamine-regulated transcript protein CARTPT 0.0062
2810 Dr hemagglutinin structural subunit draA 0.0062
6105 3-oxo-5-beta-steroid 4-dehydrogenase AKR1D1 0.0062
517 Alcohol dehydrogenase 1C ADH1C 0.0062
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0062
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0062
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0062
106 Cannabinoid receptor 2 CNR2 0.0062
3426 Glutamine synthetase glnA 0.0062
3987 Glutamine synthetase GLUL 0.0062
5923 Microtubule-associated protein tau MAPT 0.006
5924 Microtubule-associated protein 4 MAP4 0.006
859 Cellular retinoic acid-binding protein 2 CRABP2 0.006
6126 Carbonic anhydrase 7 CA7 0.006
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0059
634 Squalene monooxygenase SQLE 0.0059
7196 Squalene monooxygenase ERG1 0.0059
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0059
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0059
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0058
6138 Multidrug resistance protein 3 ABCB4 0.0058
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0058
5880 Thrombopoietin receptor MPL 0.0058
569 Retinal dehydrogenase 2 ALDH1A2 0.0058
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0057
6146 High affinity copper uptake protein 1 SLC31A1 0.0056
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0056
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0056
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0056
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0055
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0055
6506 Stathmin-4 STMN4 0.0055
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0054
558 Solute carrier family 12 member 1 SLC12A1 0.0054
611 Retinal dehydrogenase 1 ALDH1A1 0.0054
3856 Fibroblast growth factor receptor 3 FGFR3 0.0053
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0053
33 Cystine/glutamate transporter SLC7A11 0.0053
5998 Toll-like receptor 8 TLR8 0.0053
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0053
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0052
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0052
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0052
1992 Vitamin D-binding protein GC 0.0052
712 Tubulin alpha chain TUB1 0.0052
1039 Histone deacetylase 9 HDAC9 0.0052
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0052
3913 Glutamic acid decarboxylase GAD65 0.0052
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.0051
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0051
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0051
1360 Sphingomyelin phosphodiesterase SMPD1 0.0051
291 Nitric-oxide synthase, endothelial NOS3 0.0051
5787 Angiopoietin-1 receptor TEK 0.0051
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.005
3937 Fatty-acid amide hydrolase FAAH 0.005
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.005
613 Atrial natriuretic peptide receptor A NPR1 0.005
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.005
4773 Deoxycytidine kinase DCK 0.005
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0049
6043 Putative G-protein coupled receptor 44 GPR44 0.0049
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0049
267 Plasminogen activator inhibitor 1 SERPINE1 0.0049
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0049
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0048
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0048
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0047
4217 Telomerase reverse transcriptase TERT 0.0047
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0046
4228 Keratin, type II cytoskeletal 7 KRT7 0.0046
992 Protein tyrosine kinase 2 beta PTK2B 0.0045
527 Prostacyclin receptor PTGIR 0.0045
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0045
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0045
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0045
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0045
572 Integrin alpha-L ITGAL 0.0045
3639 Thymidine phosphorylase deoA 0.0044
3936 Thymidine phosphorylase TYMP 0.0044
6221 Steroid hormone receptor ERR1 ESRRA 0.0044
6048 Troponin C, skeletal muscle TNNC2 0.0044
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0044
130 Prostacyclin synthase PTGIS 0.0044
1262 Corticotropin-lipotropin POMC 0.0044
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0044
3904 Alanine aminotransferase 2 GPT2 0.0043
735 Alanine aminotransferase 1 GPT 0.0043
3917 Methylenetetrahydrofolate reductase MTHFR 0.0043
4103 Proteasome subunit beta type 2 PSMB2 0.0043
4226 Uridine phosphorylase 2 UPP2 0.0043
4102 Proteasome subunit beta type 5 PSMB5 0.0043
4101 Proteasome subunit beta type 1 PSMB1 0.0043
936 Ephrin type-A receptor 2 EPHA2 0.0042
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0042
714 Glutathione reductase, mitochondrial GSR 0.0042
1864 RET proto-oncogene RET 0.0042
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0042
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0042
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0042
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0041
2298 Cytochrome P450-cam camC 0.0041
2449 Tubulin alpha-3 chain TUBA1A 0.0041
459 Retinoic acid receptor RXR-alpha RXRA 0.0041
3997 Cytochrome P450 24A1, mitochondrial CYP24A1 0.0041
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.004
1353 DNA topoisomerase 1 TOP1 0.004
3552 DNA topoisomerase 1 topA 0.004
2268 Cholesterol oxidase choB 0.0039
2822 Cholesterol oxidase choA 0.0039
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0039
4225 Uridine phosphorylase 1 UPP1 0.0039
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.0039
1129 C-C chemokine receptor type 5 CCR5 0.0039
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0038
4164 Potassium voltage-gated channel subfamily KQT member 5 KCNQ5 0.0038
4163 Potassium voltage-gated channel subfamily KQT member 4 KCNQ4 0.0038
605 Fumarate reductase flavoprotein subunit frdA 0.0038
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0038
3673 Fumarate reductase flavoprotein subunit fccA 0.0038
4912 Fumarate reductase flavoprotein subunit ifcA 0.0038
6549 Fumarate reductase flavoprotein subunit frdA 0.0038
4192 DNA topoisomerase 2-beta TOP2B 0.0038
3957 Adenosine deaminase ADA 0.0038
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0038
2981 Phospholipase A2, membrane associated PLA2G2A 0.0038
85 Growth hormone receptor GHR 0.0038
1525 Heparin-binding growth factor 2 FGF2 0.0037
6103 Arylamine N-acetyltransferase 1 NAT1 0.0037
2283 Steroid Delta-isomerase ksi 0.0037
2920 Steroid Delta-isomerase ksi 0.0037
2320 Thymidine kinase, cytosolic TK1 0.0037
413 Amidophosphoribosyltransferase PPAT 0.0037
2515 Amidophosphoribosyltransferase purF 0.0037
3714 Amidophosphoribosyltransferase purF 0.0037
908 Glutathione S-transferase theta-1 GSTT1 0.0036
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0036
633 Penicillin-binding proteins 1A/1B pbpA 0.0036
543 Penicillin-binding protein 1B mrcB 0.0035
6186 Penicillin-binding protein 1B ponB 0.0035
6822 Penicillin-binding protein 1b pbp1b 0.0035
6844 Penicillin-binding protein 1b pbp1b 0.0035
185 Vasopressin V1a receptor AVPR1A 0.0035
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0035
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0035
117 Sterol O-acyltransferase 1 SOAT1 0.0035
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0035
1268 Neuropeptide S receptor NPSR1 0.0035
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0035
159 Penicillin-binding protein 2B penA 0.0035
6121 Penicillin-binding protein 2B penA 0.0035
939 50S ribosomal protein L3 rplC 0.0035
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0034
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0034
322 Vasopressin V2 receptor AVPR2 0.0034
2325 Sulfotransferase family cytosolic 2B member 1 SULT2B1 0.0034
2499 Tubulin beta-2C chain TUBB2C 0.0034
820 Glycine receptor subunit alpha-2 GLRA2 0.0034
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0033
229 Retinoic acid receptor beta RARB 0.0033
730 Retinoic acid receptor alpha RARA 0.0032
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0032
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0032
5798 Mitogen-activated protein kinase 11 MAPK11 0.0032
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0032
1770 Phospholipase C PLCL1 0.0032
2841 Phospholipase C plc 0.0032
6073 Potassium channel subfamily K member 9 KCNK9 0.0032
6072 Potassium channel subfamily K member 3 KCNK3 0.0032
140 30S ribosomal protein S9 rpsI 0.0031
6719 30S ribosomal protein S9 rpsI 0.0031
6725 30S ribosomal protein S9 rpsI 0.0031
2207 Rhodopsin RHO 0.0031
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0031
1227 Cytochrome b MT-CYB 0.0031
6386 Cytochrome b petB 0.0031
6937 Cytochrome b MT-CYB 0.0031
674 Dihydroorotate dehydrogenase homolog, mitochondrial PFF0160c 0.0031
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0031
2578 Tubulin beta-3 chain TUBB3 0.003
6149 Solute carrier family 22 member 10 SLC22A10 0.003
2285 Streptogramin A acetyltransferase vatD 0.003
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.003
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.003
2216 Fibroblast growth factor receptor 4 FGFR4 0.0029
268 Adenosine A2b receptor ADORA2B 0.0029
6824 Tyrosine-protein kinase Lyn LYN 0.0029
512 DNA-directed RNA polymerase alpha chain rpoA 0.0029
5772 DNA-directed RNA polymerase alpha chain rpoA 0.0029
1200 AMBP protein AMBP 0.0028
3866 Serum amyloid A protein SAA1 0.0028
1932 Apolipoprotein E APOE 0.0028
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0027
400 Coagulation factor IX F9 0.0027
5461 Coagulation factor IX F9 0.0027
1144 Hepatocyte growth factor receptor MET 0.0027
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0027
4173 Tyrosine-protein kinase JAK2 JAK2 0.0027
2159 Quinone oxidoreductase CRYZ 0.0027
3849 Insulin-like growth factor-binding protein 7 IGFBP7 0.0027
2009 Protein NOV homolog NOV 0.0027
3847 Neuroendocrine convertase 2 PCSK2 0.0027
1949 Carboxypeptidase E CPE 0.0027
3850 Synaptotagmin-like protein 4 SYTL4 0.0027
3848 Neuroendocrine convertase 1 PCSK1 0.0027
3846 Retinoblastoma-associated protein RB1 0.0027
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0027
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0026
790 DNA polymerase subunit alpha B POLA2 0.0026
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0026
4081 Vitamin K epoxide reductase complex subunit 1-like protein 1 VKORC1L1 0.0025
604 Vitamin K-dependent protein Z PROZ 0.0025
6033 High affinity interleukin-8 receptor A CXCR1 0.0025
3830 Calreticulin CALR 0.0025
390 Adenosine A3 receptor ADORA3 0.0025
544 Potassium voltage-gated channel subfamily E member 1 KCNE1 0.0024
2300 Lysozyme E 0.0024
3633 Lysozyme R 0.0024
5597 Lysozyme 17 0.0024
6039 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A PDE11A 0.0024
6070 Nischarin NISCH 0.0024
5852 Type-2 angiotensin II receptor AGTR2 0.0024
6034 Hydroxyindole O-methyltransferase ASMT 0.0023
6035 Nuclear receptor ROR-beta RORB 0.0023
6036 Eosinophil peroxidase EPX 0.0023
550 Amiloride-sensitive sodium channel subunit delta SCNN1D 0.0023
27 Amiloride-sensitive sodium channel subunit beta SCNN1B 0.0023
552 Amiloride-sensitive sodium channel subunit gamma SCNN1G 0.0023
213 Amiloride-sensitive sodium channel subunit alpha SCNN1A 0.0023
1830 5'-nucleotidase NT5E 0.0023
65 Matrix metalloproteinase-9 Not Available 0.0023
1245 Vitamin K-dependent protein S PROS1 0.0023
422 Vitamin K-dependent protein C PROC 0.0023
1341 Histamine H3 receptor HRH3 0.0023
3404 Exotoxin A eta 0.0022
896 Glutathione S-transferase Mu 1 GSTM1 0.0022
2155 Insulin-degrading enzyme IDE 0.0022
2232 Interleukin-5 IL5 0.0022
298 Renin REN 0.0021
1593 Mucin-2 MUC2 0.0021
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0021
1063 Signal transducer and activator of transcription 5B STAT5B 0.0021
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.0021
2091 Endoplasmin HSP90B1 0.0021
1244 Low-density lipoprotein receptor-related protein 2 LRP2 0.0021
63 Malate dehydrogenase mdh 0.0021
2329 Malate dehydrogenase mdh 0.0021
3445 Malate dehydrogenase mdh 0.0021
4420 Malate dehydrogenase mdh 0.0021
4438 Malate dehydrogenase mdh 0.0021
828 Phenylalanine-4-hydroxylase PAH 0.0021
3109 Phenylalanine-4-hydroxylase phhA 0.0021
594 Thyroxine-binding globulin SERPINA7 0.002
448 Vitamin K-dependent gamma-carboxylase GGCX 0.002
765 Indoleamine 2,3-dioxygenase IDO1 0.002
3090 Chitosanase csn 0.002
4149 Nuclear factor NF-kappa-B p100 subunit NFKB2 0.002
3611 Cytidine deaminase cdd 0.002
3707 Cytidine deaminase cdd 0.002
4211 Cytidine deaminase CDA 0.002
2021 Thrombomodulin THBD 0.002
1820 Beta-nerve growth factor NGF 0.002
6218 Pannexin-1 PANX1 0.0019
1291 cAMP response element-binding protein CREB1 0.0019
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0019
760 Fibroblast growth factor 1 FGF1 0.0019
473 L-lactate dehydrogenase A chain LDHA 0.0019
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0019
798 Osteocalcin BGLAP 0.0019
758 Thyroid hormone receptor alpha THRA 0.0019
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0018
893 [Citrate [pro-3S]-lyase] ligase citC 0.0018
845 Pyruvate dehydrogenase [cytochrome] poxB 0.0018
1253 Interferon gamma IFNG 0.0018
4210 Toll-like receptor 4 TLR4 0.0018
6766 O-GlcNAcase BT_4395 BT_4395 0.0018
489 Monocarboxylate transporter 2 SLC16A7 0.0018
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0018
327 Glutathione reductase gor 0.0018
5110 Glutathione reductase GR2 0.0018
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0018
683 Potassium transporter GK0582 0.0018
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.0018
1123 Eosinophil cationic protein RNASE3 0.0018
199 Monocarboxylate transporter 8 SLC16A2 0.0018
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.0017
484 Tyrosine-protein kinase ABL2 ABL2 0.0017
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0017
2290 ADP-ribosyl cyclase 2 BST1 0.0017
6163 Copper-transporting ATPase 2 ATP7B 0.0017
6165 Copper-transporting ATPase 1 ATP7A 0.0017
369 Coagulation factor VII F7 0.0017
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0017
346 Thyroid hormone receptor beta-1 THRB 0.0017
78 Acetyl-CoA acetyltransferase, mitochondrial ACAT1 0.0016
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0016
144 Hemoglobin subunit alpha HBA1 0.0016
1243 Cathepsin D CTSD 0.0016
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0016
3233 Bile acid receptor NR1H4 0.0015
2853 14 kDa fatty acid-binding protein Not Available 0.0015
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0015
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0015
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0015
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0015
1714 Mitogen-activated protein kinase 3 MAPK3 0.0015
3844 HLA class II histocompatibility antigen, DQ(6) alpha chain HLA-DQA2 0.0015
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0015
6167 Organic solute transporter subunit beta OSTB 0.0014
6166 Organic solute transporter subunit alpha OSTA 0.0014
2599 Tyrosine-protein kinase HCK HCK 0.0014
6859 Protein S100-A4 S100A4 0.0014
1792 Tissue-type plasminogen activator PLAT 0.0014
244 Angiotensin-converting enzyme ACE 0.0013
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0013
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0013
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0013
2236 Casein kinase II subunit alpha CSNK2A1 0.0013
6211 Tubulin epsilon chain TUBE1 0.0013
6212 Tubulin gamma-1 chain TUBG1 0.0013
6210 Tubulin delta chain TUBD1 0.0013
6168 Solute carrier family 22 member 16 SLC22A16 0.0013
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0013
6131 Carbonic anhydrase 14 CA14 0.0013
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0013
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0013
860 Nicotinamide N-methyltransferase NNMT 0.0013
5626 Nucleoside diphosphate kinase B NME2 0.0013
1650 Heme carrier protein 1 SLC46A1 0.0013
699 Nicotinic acid receptor 1 GPR109A 0.0013
928 Nicotinic acid receptor 2 GPR109B 0.0013
583 Nicotinate-nucleotide pyrophosphorylase [carboxylating] QPRT 0.0013
2442 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
2459 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
6116 Gastric triacylglycerol lipase LIPF 0.0012
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0012
3823 Cytokine receptor common gamma chain IL2RG 0.0012
2107 Microtubule-associated protein 1A MAP1A 0.0012
338 DNA polymerase UL30 0.0012
379 DNA polymerase UL54 0.0012
697 DNA polymerase ORF28 0.0012
2482 DNA polymerase 43 0.0012
4104 DNA polymerase BALF5 0.0012
6122 Carbonic anhydrase 3 CA3 0.0012
4948 Cytochrome c-553 Not Available 0.0012
4923 Cytochrome c3 DvMF_2499 0.0012
4945 Cytochrome c3 Not Available 0.0012
4949 Cytochrome c3 DVU_3171 0.0012
4968 Cytochrome c3 cytc3 0.0012
4997 Cytochrome c3 SO_2727 0.0012
5219 Cytochrome c3 cyd 0.0012
1295 Fatty acid synthase FASN 0.0012
4902 Nine-heme cytochrome c Ddes_2038 0.0012
3189 High-molecular-weight cytochrome c hmcA 0.0012
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0012
5433 UPF0230 protein TM_1468 TM_1468 0.0012
5431 Lipid binding protein Not Available 0.0012
3616 Fatty acid-binding protein, epidermal FABP5 0.0012
5430 Hepatocyte nuclear factor 4-gamma HNF4G 0.0012
76 Nitric-oxide synthase, brain NOS1 0.0012
754 Pancreatic triacylglycerol lipase PNLIP 0.0011
707 72 kDa type IV collagenase MMP2 0.0011
2178 Metabotropic glutamate receptor 5 GRM5 0.0011
724 Interleukin-2 receptor alpha chain IL2RA 0.0011
717 Interleukin-2 receptor subunit beta IL2RB 0.0011
1810 Protein S100-A1 S100A1 0.001
6097 Protein S100-A2 S100A2 0.001
4386 Hemoglobin-like protein HbN glbN 0.001
493 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial CYP27B1 0.001
5294 Nucleoside diphosphate kinase A NME1 0.001
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.001
283 SEC14-like protein 2 SEC14L2 0.001
4041 Microsomal glutathione S-transferase 2 MGST2 0.001
6151 Monocarboxylate transporter 10 SLC16A10 0.001
6837 Serine/threonine-protein kinase 17B STK17B 0.001
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.001
5432 Trafficking protein particle complex subunit 3 TRAPPC3 0.0009
2211 Fatty acid-binding protein, heart FABP3 0.0009
6459 Glycodelin PAEP 0.0009
1064 DNA (cytosine-5)-methyltransferase 1 DNMT1 0.0009
3221 Cytochrome c4 cc4 0.0009
1048 Protein S100-A13 S100A13 0.0009
2226 Protein S100-A12 S100A12 0.0009
6042 Prostaglandin reductase 2 PTGR2 0.0009
6677 Myelin P2 protein PMP2 0.0009
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0009
2132 Protein S100-B S100B 0.0009
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.0008
22 30S ribosomal protein S4 rpsD 0.0008
6714 30S ribosomal protein S4 rpsD 0.0008
4954 Soluble cytochrome b558 Not Available 0.0008
4925 Cytochrome c-type protein SHP shp 0.0008
4916 Cyanoglobin glbN 0.0008
4947 Bacterial hemoglobin vhb 0.0008
4915 Cytochrome c-550 psbV 0.0008
4959 Cytochrome c-550 psbV 0.0008
5216 Cytochrome c-550 psbV 0.0008
4934 Cytochrome c-551 nirM 0.0008
5218 Cytochrome c-551 nirM 0.0008
4943 Cytochrome c6 petJ 0.0008
4975 Cytochrome c-556 RPA3973 0.0008
4936 Cytochrome c2 iso-2 Not Available 0.0008
4994 Hemoglobin-like protein HbO glbO 0.0008
4905 Cytochrome c2 Not Available 0.0008
4939 Cytochrome c2 cycA 0.0008
4964 Cytochrome c2 cycA 0.0008
4979 Cytochrome c2 cycA 0.0008
6673 Cytochrome c2 cycA 0.0008
4984 Neuroglobin NGB 0.0008
4998 Hemoglobin-like protein yjbI yjbI 0.0008
3116 Bacterioferritin bfr 0.0008
4906 Bacterioferritin bfr 0.0008
4965 Bacterioferritin bfr 0.0008
5000 HemO hemO 0.0008
4910 Cytoglobin CYGB 0.0008
4909 CooA protein cooA 0.0008
4981 Iron-starvation protein PigA pigA 0.0008
4907 Cytochrome c-L moxG 0.0008
6865 Cytochrome c-L moxG 0.0008
644 Heme oxygenase 2 HMOX2 0.0008
4982 Heme oxygenase 2 pbsA2 0.0008
4942 Diheme cytochrome c napB napB 0.0008
4935 Cytochrome c-554 cycA1 0.0008
4961 Hemophore HasA hasA 0.0008
4904 Cytochrome c family protein GSU1996 0.0008
4971 Nonaheme cytochrome c hmcA 0.0008
4976 Apocytochrome f petA 0.0008
6407 Apocytochrome f petA 0.0008
4764 Cytochrome P450 165C4 CYP165C4 0.0008
4999 Cytochrome P450 165B3 CYP165B3 0.0008
4960 Putative cytochrome P450-family protein SCO7417 0.0008
4931 Cytochrome P450 167A1 CYP167A1 0.0008
4989 Cytochrome c551 peroxidase ccp 0.0008
5222 Cytochrome c551 peroxidase ccpA 0.0008
4937 Cytochrome oxidase subunit II rcoxA 0.0008
4972 P450cin cinA 0.0008
4903 Methyl-accepting chemotaxis protein Tar4 0.0008
4926 Heme-based aerotactic transducer hemAT hemAT 0.0008
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0008
4922 Cytochrome c, putative SO_4144 0.0008
4993 Hydroxylamine oxidoreductase hao1 0.0008
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0008
3093 Catalase HPII katE 0.0008
4952 Catalase/peroxidase katA 0.0008
1867 Major prion protein PRNP 0.0008
1507 Cytochrome c CYCS 0.0008
4031 Glutathione S-transferase A1 GSTA1 0.0008
6599 HTH-type transcriptional regulator ttgR ttgR 0.0008
500 Monocarboxylate transporter 4 SLC16A3 0.0008
1649 Small inducible cytokine A2 CCL2 0.0008
1025 Aquaporin-1 AQP1 0.0008
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.0007
866 Large neutral amino acids transporter small subunit 2 SLC7A8 0.0007
461 Glycine receptor subunit alpha-3 GLRA3 0.0007
822 Aldose reductase AKR1B1 0.0007
6228 Nuclear receptor coactivator 1 NCOA1 0.0007
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.0007
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.0007
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.0007
6207 30S ribosomal protein S14 rpsN 0.0007
6209 30S ribosomal protein S19 rpsS 0.0007
6712 30S ribosomal protein S19 rpsS 0.0007
6726 30S ribosomal protein S19 rpsS 0.0007
6134 Sodium channel subunit beta-3 SCN3B 0.0007
6133 Sodium channel subunit beta-2 SCN2B 0.0007
6135 Sodium channel subunit beta-4 SCN4B 0.0007
6241 Nuclear receptor coactivator 2 NCOA2 0.0007
6132 Sodium channel subunit beta-1 SCN1B 0.0007
6129 Carbonic anhydrase-related protein 11 CA11 0.0007
6127 Carbonic anhydrase-related protein CA8 0.0007
6128 Carbonic anhydrase-related protein 10 CA10 0.0007
645 Penicillin-binding protein 1A mrcA 0.0007
5805 Penicillin-binding protein 1A ponA 0.0007
6185 Penicillin-binding protein 1A mrcA 0.0007
6799 Penicillin-binding protein 1A pbpA 0.0007
1313 Lactoylglutathione lyase GLO1 0.0007
226 Gonadotropin-releasing hormone receptor GNRHR 0.0007
125 DNA polymerase beta POLB 0.0007
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0006
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.0006
6130 Carbonic anhydrase 13 CA13 0.0006
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0006
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0006
4920 Peroxidase/catalase katG 0.0006
2119 Cytochrome b5 CYB5A 0.0006
4990 PpcA ppcA 0.0006
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0006
3375 Acidic cytochrome c3 Not Available 0.0006
4988 Sulfite oxidase, mitochondrial SUOX 0.0006
2915 Sensor protein fixL fixL 0.0006
4944 Sensor protein fixL fixL 0.0006
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.0006
4385 Cytochrome c' Not Available 0.0006
4967 Cytochrome c' cycA 0.0006
5038 Cytochrome c' Not Available 0.0006
5223 Cytochrome c' cycP 0.0006
3570 Cytochrome P450 152A1 cypC 0.0006
4813 Heme oxygenase hmuO 0.0006
5769 Heme oxygenase Not Available 0.0006
4037 Hypothetical protein GPX1 0.0006
4297 Hypothetical protein SP_1951 0.0006
4521 Hypothetical protein BC_2969 0.0006
4540 Hypothetical protein TM_1070 0.0006
4555 Hypothetical protein MT1739 0.0006
4569 Hypothetical protein mshD 0.0006
4578 Hypothetical protein PA3270 0.0006
4747 Hypothetical protein PA3967 0.0006
5177 Hypothetical protein TM_0096 0.0006
5194 Hypothetical protein PA1204 0.0006
5240 Hypothetical protein Rv2991 0.0006
5370 Hypothetical protein TM_1158 0.0006
5710 Hypothetical protein Tb927.5.1360 0.0006
4289 Cytochrome P450 TT_P0059 0.0006
6262 Cytochrome P450 staP 0.0006
4992 Cytochrome c peroxidase Not Available 0.0006
1569 G1/S-specific cyclin-D1 CCND1 0.0006
5221 Cytochrome c3, 13 kDa Not Available 0.0006
3152 Cytochrome c'' cycA 0.0006
5220 Split-Soret cytochrome c Ddes_2150 0.0006
3700 Cytochrome c-552 precursor nrfA 0.0006
1760 Aminopeptidase N ANPEP 0.0005
6843 Aminopeptidase N pepN 0.0005
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0005
3411 Cytochrome P450 121 cyp121 0.0005
3670 Soluble cytochrome b562 precursor cybC 0.0005
3291 Cytochrome c-552 cycA 0.0005
4927 Cytochrome c-552 nrfA 0.0005
4938 Cytochrome c-552 cycA 0.0005
4953 Cytochrome c-552 nrfA 0.0005
5217 Cytochrome c-552 cycM 0.0005
2617 Nitric oxide synthase oxygenase nos 0.0005
2701 Nitric oxide synthase oxygenase nos 0.0005
3102 Flavohemoprotein hmp 0.0005
4969 Flavohemoprotein hmp 0.0005
3007 Carbonic anhydrase 12 CA12 0.0005
4205 Carbonic anhydrase 9 CA9 0.0005
3127 Nitrite reductase nirS 0.0005
3284 Nitrite reductase nirS 0.0005
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0005
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0005
2972 6-deoxyerythronolide B hydroxylase eryF 0.0005
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0004
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0004
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0004
4608 Putative cytochrome P450 SCO1207 0.0004
4963 Putative cytochrome P450 SCO2884 0.0004
6254 Putative cytochrome P450 SCO6998 0.0004
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0004
3405 Quinohaemoprotein ethanol dehydrogenase type-1 qheDH 0.0004
358 Cystathionine beta-synthase CBS 0.0004
693 Hemoglobin subunit beta HBB 0.0004
1176 Mitogen-activated protein kinase 1 MAPK1 0.0004
6268 Hydroxyacid oxidase 1 HAO1 0.0004
810 Heme oxygenase 1 HMOX1 0.0004
3391 Heme oxygenase 1 pbsA1 0.0004
2240 Cell division protein kinase 2 CDK2 0.0003
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