DT-Web: DB01388

Identification

Name

Mibefradil

Accession Number

DB01388

Type

small molecule

Description

Mibefradil was withdrawn from the market in 1998 because of potentially harmful interactions with other drugs.

Structure

MOL SDF PDB SMILES InChI

Categories ^(*)

Molecular Weight

495.6287

Groups

withdrawn

Monoisotopic Weight

495.289720302

Pharmacology

Indication

For the treatment of angina and high blood pressure.

Mechanism of action

Mibefradil is a tetralol calcium channel blocking agent that inhibits the influx of calcium ions across both the T (low-voltage) and L (high-voltage) calcium channels of cardiac and vascular smooth muscle, with a greater selectivity for T channels. Vasodilation occurs in vascular smooth muscle, causing a decrease in peripheral vascular resistance and a resulting decrease in blood pressure. Mibefradil causes a slight increase in cardiac output during chronic dosing. Mibefradil slows sinus and atrioventricular (AV) node conduction, producing a slight reduction in heart rate and a slight increase in the PR interval. It has also been shown to slightly lengthen the corrected sinus node recovery time and AH interval and to raise the Wenckebach point. The mechanism by which mibefradil reduces angina is not known, but is thought to be attributed to a reduction in heart rate, total peripheral resistance (afterload), and the heart rate–systolic blood pressure product at any given level of exercise. The result of these effects is a decrease in cardiac workload and myocardial oxygen demand.

Absorption

Bioavailability after a single dose is 70%. After multiple dosing, the proportion of mibefradil undergoing first-pass metabolism is reduced, resulting in a steady state bioavailability of approximately 90%. Food does not affect the rate or extent of absorption of mibefradil.

Protein binding

≥ 99%, primarily to alpha 1-acid glycoprotein.

Biotransformation

The two metabolic pathways that mibefradil undergoes are esterase-catalyzed hydrolysis of the ester side chain (producing an alcohol metabolite) and cytochrome P450 3A4-catalyzed oxidation (that becomes less important during chronic dosing). The pharmacologic effect of the metabolite is approximately 10% of that of the parent mibefradil.

Route of elimination

Not Available

Toxicity

Not Available

Affected organisms

Humans and other mammals

Interactions

Drug Interactions

Drug	Mechanism of interaction
Astemizole	Increased risk of cardiotoxicity and arrhythmias
Atomoxetine	The CYP2D6 inhibitor could increase the effect and toxicity of atomoxetine
Cisapride	Mibefradil increases levels of cisapride
Tacrolimus	The calcium channel blocker, Mibefradil, may increase the blood concentration of Tacrolimus. Monitor for changes in the therapeutic/toxic effects of Tacrolimus if Mibefradil therapy is initiated, discontinued or altered.
Terfenadine	Increased risk of cardiotoxicity and arrhythmias

Food Interactions

Not Available

Voltage-dependent T-type calcium channel subunit alpha-1G
Name	Voltage-dependent T-type calcium channel subunit alpha-1G
Gene Name	CACNA1G
Pharmacological action	yes
Actions	inhibitor
References	Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed Lee TS, Kaku T, Takebayashi S, Uchino T, Miyamoto S, Hadama T, Perez-Reyes E, Ono K: Actions of mibefradil, efonidipine and nifedipine block of recombinant T- and L-type Ca channels with distinct inhibitory mechanisms. Pharmacology. 2006;78(1):11-20. Epub 2006 Aug 7. - Pubmed Monteil A, Chemin J, Bourinet E, Mennessier G, Lory P, Nargeot J: Molecular and functional properties of the human alpha(1G) subunit that forms T-type calcium channels. J Biol Chem. 2000 Mar 3;275(9):6090-100. - Pubmed Massie BM: Mibefradil: a selective T-type calcium antagonist. Am J Cardiol. 1997 Nov 6;80(9A):23I-32I. - Pubmed Clozel JP, Ertel EA, Ertel SI: Discovery and main pharmacological properties of mibefradil (Ro 40-5967), the first selective T-type calcium channel blocker. J Hypertens Suppl. 1997 Dec;15(5):S17-25. - Pubmed McNulty MM, Hanck DA: State-dependent mibefradil block of Na+ channels. Mol Pharmacol. 2004 Dec;66(6):1652-61. - Pubmed
DTHybrid score	0.4334
Voltage-dependent T-type calcium channel subunit alpha-1H
Name	Voltage-dependent T-type calcium channel subunit alpha-1H
Gene Name	CACNA1H
Pharmacological action	yes
Actions	inhibitor
References	Brueggemann LI, Martin BL, Barakat J, Byron KL, Cribbs LL: Low voltage-activated calcium channels in vascular smooth muscle: T-type channels and AVP-stimulated calcium spiking. Am J Physiol Heart Circ Physiol. 2005 Feb;288(2):H923-35. Epub 2004 Oct 21. - Pubmed Coste B, Crest M, Delmas P: Pharmacological dissection and distribution of NaN/Nav1.9, T-type Ca2+ currents, and mechanically activated cation currents in different populations of DRG neurons. J Gen Physiol. 2007 Jan;129(1):57-77. - Pubmed Cribbs LL, Lee JH, Yang J, Satin J, Zhang Y, Daud A, Barclay J, Williamson MP, Fox M, Rees M, Perez-Reyes E: Cloning and characterization of alpha1H from human heart, a member of the T-type Ca2+ channel gene family. Circ Res. 1998 Jul 13;83(1):103-9. - Pubmed Lee TS, Kaku T, Takebayashi S, Uchino T, Miyamoto S, Hadama T, Perez-Reyes E, Ono K: Actions of mibefradil, efonidipine and nifedipine block of recombinant T- and L-type Ca channels with distinct inhibitory mechanisms. Pharmacology. 2006;78(1):11-20. Epub 2006 Aug 7. - Pubmed Perez-Reyes E: Paradoxical Role of T-type Calcium Channels in Coronary Smooth Muscle. Mol Interv. 2004 Feb;4(1):16-8. - Pubmed Massie BM: Mibefradil: a selective T-type calcium antagonist. Am J Cardiol. 1997 Nov 6;80(9A):23I-32I. - Pubmed Clozel JP, Ertel EA, Ertel SI: Discovery and main pharmacological properties of mibefradil (Ro 40-5967), the first selective T-type calcium channel blocker. J Hypertens Suppl. 1997 Dec;15(5):S17-25. - Pubmed McNulty MM, Hanck DA: State-dependent mibefradil block of Na+ channels. Mol Pharmacol. 2004 Dec;66(6):1652-61. - Pubmed
DTHybrid score	0.4179
Voltage-dependent L-type calcium channel subunit alpha-1C
Name	Voltage-dependent L-type calcium channel subunit alpha-1C
Gene Name	CACNA1C
Pharmacological action	yes
Actions	inhibitor
References	Moosmang S, Haider N, Bruderl B, Welling A, Hofmann F: Antihypertensive effects of the putative T-type calcium channel antagonist mibefradil are mediated by the L-type calcium channel Cav1.2. Circ Res. 2006 Jan 6;98(1):105-10. Epub 2005 Nov 23. - Pubmed Lee TS, Kaku T, Takebayashi S, Uchino T, Miyamoto S, Hadama T, Perez-Reyes E, Ono K: Actions of mibefradil, efonidipine and nifedipine block of recombinant T- and L-type Ca channels with distinct inhibitory mechanisms. Pharmacology. 2006;78(1):11-20. Epub 2006 Aug 7. - Pubmed Mocanu MM, Gadgil S, Yellon DM, Baxter GF: Mibefradil, a T-type and L-type calcium channel blocker, limits infarct size through a glibenclamide-sensitive mechanism. Cardiovasc Drugs Ther. 1999 Apr;13(2):115-22. - Pubmed Jimenez C, Bourinet E, Leuranguer V, Richard S, Snutch TP, Nargeot J: Determinants of voltage-dependent inactivation affect Mibefradil block of calcium channels. Neuropharmacology. 2000;39(1):1-10. - Pubmed
DTHybrid score	0.793
Voltage-dependent L-type calcium channel subunit alpha-1D
Name	Voltage-dependent L-type calcium channel subunit alpha-1D
Gene Name	CACNA1D
Pharmacological action	yes
Actions	inhibitor
References	Mocanu MM, Gadgil S, Yellon DM, Baxter GF: Mibefradil, a T-type and L-type calcium channel blocker, limits infarct size through a glibenclamide-sensitive mechanism. Cardiovasc Drugs Ther. 1999 Apr;13(2):115-22. - Pubmed Jimenez C, Bourinet E, Leuranguer V, Richard S, Snutch TP, Nargeot J: Determinants of voltage-dependent inactivation affect Mibefradil block of calcium channels. Neuropharmacology. 2000;39(1):1-10. - Pubmed Lee TS, Kaku T, Takebayashi S, Uchino T, Miyamoto S, Hadama T, Perez-Reyes E, Ono K: Actions of mibefradil, efonidipine and nifedipine block of recombinant T- and L-type Ca channels with distinct inhibitory mechanisms. Pharmacology. 2006;78(1):11-20. Epub 2006 Aug 7. - Pubmed
DTHybrid score	0.6744
Voltage-dependent L-type calcium channel subunit alpha-1F
Name	Voltage-dependent L-type calcium channel subunit alpha-1F
Gene Name	CACNA1F
Pharmacological action	yes
Actions	inhibitor
References	Mocanu MM, Gadgil S, Yellon DM, Baxter GF: Mibefradil, a T-type and L-type calcium channel blocker, limits infarct size through a glibenclamide-sensitive mechanism. Cardiovasc Drugs Ther. 1999 Apr;13(2):115-22. - Pubmed Jimenez C, Bourinet E, Leuranguer V, Richard S, Snutch TP, Nargeot J: Determinants of voltage-dependent inactivation affect Mibefradil block of calcium channels. Neuropharmacology. 2000;39(1):1-10. - Pubmed Lee TS, Kaku T, Takebayashi S, Uchino T, Miyamoto S, Hadama T, Perez-Reyes E, Ono K: Actions of mibefradil, efonidipine and nifedipine block of recombinant T- and L-type Ca channels with distinct inhibitory mechanisms. Pharmacology. 2006;78(1):11-20. Epub 2006 Aug 7. - Pubmed
DTHybrid score	0.4707
Voltage-dependent T-type calcium channel subunit alpha-1I
Name	Voltage-dependent T-type calcium channel subunit alpha-1I
Gene Name	CACNA1I
Pharmacological action	yes
Actions	inhibitor
References	Massie BM: Mibefradil: a selective T-type calcium antagonist. Am J Cardiol. 1997 Nov 6;80(9A):23I-32I. - Pubmed Clozel JP, Ertel EA, Ertel SI: Discovery and main pharmacological properties of mibefradil (Ro 40-5967), the first selective T-type calcium channel blocker. J Hypertens Suppl. 1997 Dec;15(5):S17-25. - Pubmed McNulty MM, Hanck DA: State-dependent mibefradil block of Na+ channels. Mol Pharmacol. 2004 Dec;66(6):1652-61. - Pubmed Lee TS, Kaku T, Takebayashi S, Uchino T, Miyamoto S, Hadama T, Perez-Reyes E, Ono K: Actions of mibefradil, efonidipine and nifedipine block of recombinant T- and L-type Ca channels with distinct inhibitory mechanisms. Pharmacology. 2006;78(1):11-20. Epub 2006 Aug 7. - Pubmed
DTHybrid score	0.3424
Voltage-dependent L-type calcium channel subunit alpha-1S
Name	Voltage-dependent L-type calcium channel subunit alpha-1S
Gene Name	CACNA1S
Pharmacological action	yes
Actions	inhibitor
References	Mocanu MM, Gadgil S, Yellon DM, Baxter GF: Mibefradil, a T-type and L-type calcium channel blocker, limits infarct size through a glibenclamide-sensitive mechanism. Cardiovasc Drugs Ther. 1999 Apr;13(2):115-22. - Pubmed Jimenez C, Bourinet E, Leuranguer V, Richard S, Snutch TP, Nargeot J: Determinants of voltage-dependent inactivation affect Mibefradil block of calcium channels. Neuropharmacology. 2000;39(1):1-10. - Pubmed Lee TS, Kaku T, Takebayashi S, Uchino T, Miyamoto S, Hadama T, Perez-Reyes E, Ono K: Actions of mibefradil, efonidipine and nifedipine block of recombinant T- and L-type Ca channels with distinct inhibitory mechanisms. Pharmacology. 2006;78(1):11-20. Epub 2006 Aug 7. - Pubmed
DTHybrid score	0.7248
Voltage-dependent L-type calcium channel subunit beta-1
Name	Voltage-dependent L-type calcium channel subunit beta-1
Gene Name	CACNB1
Pharmacological action	yes
Actions	inhibitor
References	Lee TS, Kaku T, Takebayashi S, Uchino T, Miyamoto S, Hadama T, Perez-Reyes E, Ono K: Actions of mibefradil, efonidipine and nifedipine block of recombinant T- and L-type Ca channels with distinct inhibitory mechanisms. Pharmacology. 2006;78(1):11-20. Epub 2006 Aug 7. - Pubmed Mocanu MM, Gadgil S, Yellon DM, Baxter GF: Mibefradil, a T-type and L-type calcium channel blocker, limits infarct size through a glibenclamide-sensitive mechanism. Cardiovasc Drugs Ther. 1999 Apr;13(2):115-22. - Pubmed Jimenez C, Bourinet E, Leuranguer V, Richard S, Snutch TP, Nargeot J: Determinants of voltage-dependent inactivation affect Mibefradil block of calcium channels. Neuropharmacology. 2000;39(1):1-10. - Pubmed
DTHybrid score	0.463
Voltage-dependent L-type calcium channel subunit beta-2
Name	Voltage-dependent L-type calcium channel subunit beta-2
Gene Name	CACNB2
Pharmacological action	yes
Actions	inhibitor
References	Lee TS, Kaku T, Takebayashi S, Uchino T, Miyamoto S, Hadama T, Perez-Reyes E, Ono K: Actions of mibefradil, efonidipine and nifedipine block of recombinant T- and L-type Ca channels with distinct inhibitory mechanisms. Pharmacology. 2006;78(1):11-20. Epub 2006 Aug 7. - Pubmed Mocanu MM, Gadgil S, Yellon DM, Baxter GF: Mibefradil, a T-type and L-type calcium channel blocker, limits infarct size through a glibenclamide-sensitive mechanism. Cardiovasc Drugs Ther. 1999 Apr;13(2):115-22. - Pubmed Jimenez C, Bourinet E, Leuranguer V, Richard S, Snutch TP, Nargeot J: Determinants of voltage-dependent inactivation affect Mibefradil block of calcium channels. Neuropharmacology. 2000;39(1):1-10. - Pubmed
DTHybrid score	0.6483
Voltage-dependent L-type calcium channel subunit beta-3
Name	Voltage-dependent L-type calcium channel subunit beta-3
Gene Name	CACNB3
Pharmacological action	yes
Actions	inhibitor
References	Lee TS, Kaku T, Takebayashi S, Uchino T, Miyamoto S, Hadama T, Perez-Reyes E, Ono K: Actions of mibefradil, efonidipine and nifedipine block of recombinant T- and L-type Ca channels with distinct inhibitory mechanisms. Pharmacology. 2006;78(1):11-20. Epub 2006 Aug 7. - Pubmed Mocanu MM, Gadgil S, Yellon DM, Baxter GF: Mibefradil, a T-type and L-type calcium channel blocker, limits infarct size through a glibenclamide-sensitive mechanism. Cardiovasc Drugs Ther. 1999 Apr;13(2):115-22. - Pubmed Jimenez C, Bourinet E, Leuranguer V, Richard S, Snutch TP, Nargeot J: Determinants of voltage-dependent inactivation affect Mibefradil block of calcium channels. Neuropharmacology. 2000;39(1):1-10. - Pubmed
DTHybrid score	0.3837
Voltage-dependent L-type calcium channel subunit beta-4
Name	Voltage-dependent L-type calcium channel subunit beta-4
Gene Name	CACNB4
Pharmacological action	yes
Actions	inhibitor
References	Lee TS, Kaku T, Takebayashi S, Uchino T, Miyamoto S, Hadama T, Perez-Reyes E, Ono K: Actions of mibefradil, efonidipine and nifedipine block of recombinant T- and L-type Ca channels with distinct inhibitory mechanisms. Pharmacology. 2006;78(1):11-20. Epub 2006 Aug 7. - Pubmed Mocanu MM, Gadgil S, Yellon DM, Baxter GF: Mibefradil, a T-type and L-type calcium channel blocker, limits infarct size through a glibenclamide-sensitive mechanism. Cardiovasc Drugs Ther. 1999 Apr;13(2):115-22. - Pubmed Jimenez C, Bourinet E, Leuranguer V, Richard S, Snutch TP, Nargeot J: Determinants of voltage-dependent inactivation affect Mibefradil block of calcium channels. Neuropharmacology. 2000;39(1):1-10. - Pubmed
DTHybrid score	0.3848

Cytochrome P450 3A4
Name	Cytochrome P450 3A4
Gene Name	CYP3A4
Actions	substrate,inhibitor
References	Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	1.0117
Cytochrome P450 1A2
Name	Cytochrome P450 1A2
Gene Name	CYP1A2
Actions	inhibitor
References	Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.6422
Cytochrome P450 2D6
Name	Cytochrome P450 2D6
Gene Name	CYP2D6
Actions	inhibitor
References	Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.7013
Cytochrome P450 3A5
Name	Cytochrome P450 3A5
Gene Name	CYP3A5
Actions	inhibitor
References	Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.675
Cytochrome P450 3A7
Name	Cytochrome P450 3A7
Gene Name	CYP3A7
Actions	inhibitor
References	Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.5372
Cytochrome P450 11B1, mitochondrial
Name	Cytochrome P450 11B1, mitochondrial
Gene Name	CYP11B1
Actions	inhibitor
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.3749
Cytochrome P450 11B2, mitochondrial
Name	Cytochrome P450 11B2, mitochondrial
Gene Name	CYP11B2
Actions	inhibitor
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.3785
Cytochrome P450 1A1
Name	Cytochrome P450 1A1
Gene Name	CYP1A1
Actions	inhibitor
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.4161

Multidrug resistance protein 1
Name	Multidrug resistance protein 1
Gene Name	ABCB1
Actions	inhibitor
References	Wandel C, Kim RB, Guengerich FP, Wood AJ: Mibefradil is a P-glycoprotein substrate and a potent inhibitor of both P-glycoprotein and CYP3A in vitro. Drug Metab Dispos. 2000 Aug;28(8):895-8. - Pubmed Ekins S, Kim RB, Leake BF, Dantzig AH, Schuetz EG, Lan LB, Yasuda K, Shepard RL, Winter MA, Schuetz JD, Wikel JH, Wrighton SA: Three-dimensional quantitative structure-activity relationships of inhibitors of P-glycoprotein. Mol Pharmacol. 2002 May;61(5):964-73. - Pubmed Schwab D, Fischer H, Tabatabaei A, Poli S, Huwyler J: Comparison of in vitro P-glycoprotein screening assays: recommendations for their use in drug discovery. J Med Chem. 2003 Apr 24;46(9):1716-25. - Pubmed Nagy H, Goda K, Fenyvesi F, Bacso Z, Szilasi M, Kappelmayer J, Lustyik G, Cianfriglia M, Szabo G Jr: Distinct groups of multidrug resistance modulating agents are distinguished by competition of P-glycoprotein-specific antibodies. Biochem Biophys Res Commun. 2004 Mar 19;315(4):942-9. - Pubmed
DTHybrid score	0.6561

Id	Partner name	Gene Name	Score
4757	Cytochrome P450 2C9	CYP2C9	0.4444
6016	Cytochrome P450 2C19	CYP2C19	0.3879
762	Voltage-dependent calcium channel subunit alpha-2/delta-1	CACNA2D1	0.3579
4924	Cytochrome P450 2C8	CYP2C8	0.3427
6030	Cytochrome P450 2B6	CYP2B6	0.2764
6013	Cytochrome P450 2E1	CYP2E1	0.2757
5718	Cytochrome P450 2A6	CYP2A6	0.2319
737	Mineralocorticoid receptor	NR3C2	0.2078
4160	Voltage-dependent calcium channel subunit alpha-2/delta-2	CACNA2D2	0.1731
750	Voltage-dependent calcium channel gamma-1 subunit	CACNG1	0.1682
101	Potassium voltage-gated channel subfamily H member 2	KCNH2	0.1491
1732	ATP-binding cassette sub-family G member 2	ABCG2	0.139
492	Histamine H1 receptor	HRH1	0.1347
6139	Solute carrier organic anion transporter family member 1A2	SLCO1A2	0.1311
6220	Aryl hydrocarbon receptor	AHR	0.1303
465	Calmodulin	CALM1	0.1207
1735	Canalicular multispecific organic anion transporter 1	ABCC2	0.12
831	D(2) dopamine receptor	DRD2	0.1177
587	Serum albumin	ALB	0.1136
1709	Canalicular multispecific organic anion transporter 2	ABCC3	0.0988
556	Alpha-1A adrenergic receptor	ADRA1A	0.0966
629	Alpha-2B adrenergic receptor	ADRA2B	0.0961
193	Beta-1 adrenergic receptor	ADRB1	0.0906
824	Sodium-dependent serotonin transporter	SLC6A4	0.0893
1490	Solute carrier organic anion transporter family member 1B1	SLCO1B1	0.0889
118	Organic cation/carnitine transporter 2	SLC22A5	0.088
862	Multidrug resistance-associated protein 1	ABCC1	0.0872
380	Cytochrome P450 17A1	CYP17A1	0.0865
220	Sodium channel protein type 5 subunit alpha	SCN5A	0.0852
6145	Solute carrier family 22 member 1	SLC22A1	0.0847
6106	Cytochrome P450 2C18	CYP2C18	0.0846
318	Alpha-2A adrenergic receptor	ADRA2A	0.0816
632	Alpha-1B adrenergic receptor	ADRA1B	0.0807
158	Sodium channel protein type 1 subunit alpha	SCN1A	0.0798
3811	Cytochrome P450 19A1	CYP19A1	0.0797
6045	Voltage-dependent calcium channel subunit alpha-2/delta-3	CACNA2D3	0.079
776	Bile salt export pump	ABCB11	0.0772
233	Potassium channel subfamily K member 2	KCNK2	0.0768
789	Alpha-1D adrenergic receptor	ADRA1D	0.0738
103	Muscarinic acetylcholine receptor M1	CHRM1	0.0726
3970	Voltage-dependent N-type calcium channel subunit alpha-1B	CACNA1B	0.0697
1898	Cytochrome P450 1B1	CYP1B1	0.0676
6047	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	PDE1A	0.0666
781	ATP-sensitive inward rectifier potassium channel 11	KCNJ11	0.0663
1181	Alpha-1-acid glycoprotein 1	ORM1	0.0654
378	Alpha-2C adrenergic receptor	ADRA2C	0.0652
5692	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	PDE1B	0.0616
871	Glucocorticoid receptor	NR3C1	0.061
392	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	CACNA1A	0.0604
833	Organic cation/carnitine transporter 1	SLC22A4	0.0565
20	Prostaglandin G/H synthase 1	PTGS1	0.056
6031	Cytochrome P450 3A43	CYP3A43	0.0559
6148	Multidrug resistance-associated protein 7	ABCC10	0.0557
872	Gamma-aminobutyric-acid receptor subunit alpha-1	GABRA1	0.0556
756	Sex hormone-binding globulin	SHBG	0.0552
540	Sodium-dependent noradrenaline transporter	SLC6A2	0.055
502	5-hydroxytryptamine 2A receptor	HTR2A	0.0544
6048	Troponin C, skeletal muscle	TNNC2	0.0538
1561	Troponin C, slow skeletal and cardiac muscles	TNNC1	0.0528
1680	Solute carrier family 2, facilitated glucose transporter member 1	SLC2A1	0.0497
94	5-hydroxytryptamine 4 receptor	HTR4	0.0497
3923	Cholinesterase	BCHE	0.0494
6144	Solute carrier family 22 member 2	SLC22A2	0.0488
2164	Multidrug resistance-associated protein 4	ABCC4	0.0483
847	Mu-type opioid receptor	OPRM1	0.0474
320	5-hydroxytryptamine 1A receptor	HTR1A	0.046
260	Cytochrome P450 51	ERG11	0.0459
761	Cytochrome P450 51	ERG11	0.0459
3163	Cytochrome P450 51	cyp51	0.0459
1729	Solute carrier family 22 member 6	SLC22A6	0.0457
766	Beta-2 adrenergic receptor	ADRB2	0.0453
6022	UDP-glucuronosyltransferase 1-1	UGT1A1	0.0422
617	Muscarinic acetylcholine receptor M2	CHRM2	0.0401
1971	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	PDE4A	0.0393
51	Muscarinic acetylcholine receptor M3	CHRM3	0.0393
6017	Cholesterol side-chain cleavage enzyme, mitochondrial	CYP11A1	0.0392
6046	Voltage-gated calcium channel beta 1 subunit splice variant CavB1d	CACNB1	0.0382
751	Potassium channel subfamily K member 6	KCNK6	0.0373
514	Potassium voltage-gated channel subfamily H member 6	KCNH6	0.0371
772	Potassium voltage-gated channel subfamily H member 7	KCNH7	0.0371
23	D(1A) dopamine receptor	DRD1	0.0366
590	5-hydroxytryptamine 2C receptor	HTR2C	0.0358
269	Adrenodoxin, mitochondrial	FDX1	0.0358
3941	Amine oxidase [flavin-containing] A	MAOA	0.0356
232	Corticosteroid-binding globulin	SERPINA6	0.0354
467	Delta-type opioid receptor	OPRD1	0.0339
172	Potassium channel subfamily K member 1	KCNK1	0.0337
469	Annexin A1	ANXA1	0.0332
136	Estrogen receptor	ESR1	0.0329
817	DNA topoisomerase 2-alpha	TOP2A	0.0329
2298	Cytochrome P450-cam	camC	0.0325
274	Muscarinic acetylcholine receptor M5	CHRM5	0.0323
713	Sodium-dependent dopamine transporter	SLC6A3	0.0322
638	D(3) dopamine receptor	DRD3	0.0321
450	Muscarinic acetylcholine receptor M4	CHRM4	0.0314
295	Carbonic anhydrase 1	CA1	0.0313
341	5-hydroxytryptamine 3 receptor	HTR3A	0.0312
6178	UDP-glucuronosyltransferase 2B7	UGT2B7	0.0306
696	Kappa-type opioid receptor	OPRK1	0.0305
6147	Solute carrier family 22 member 3	SLC22A3	0.0297
6143	Solute carrier family 22 member 7	SLC22A7	0.0297
885	5-hydroxytryptamine 1B receptor	HTR1B	0.0297
6018	UDP-glucuronosyltransferase 1-9	UGT1A9	0.0296
290	Prostaglandin G/H synthase 2	PTGS2	0.0295
731	HIV-1 protease	HIV-1 protease	0.0291
6157	Solute carrier organic anion transporter family member 1B3	SLCO1B3	0.0288
3939	Amine oxidase [flavin-containing] B	MAOB	0.0282
6142	Solute carrier family 22 member 8	SLC22A8	0.0271
468	Cytochrome P450 4A11	CYP4A11	0.027
858	Potassium voltage-gated channel subfamily A member 1	KCNA1	0.0269
36	Insulin receptor	INSR	0.0258
477	DNA topoisomerase 4 subunit A	parC	0.0253
886	DNA topoisomerase 4 subunit A	parC	0.0253
6226	DNA topoisomerase 4 subunit A	parC	0.0253
404	DNA gyrase subunit A	gyrA	0.0249
6224	DNA gyrase subunit A	gyrA	0.0249
6182	Cytochrome P450 2J2	CYP2J2	0.0247
725	5-hydroxytryptamine 1D receptor	HTR1D	0.024
1995	Sodium channel protein type 9 subunit alpha	SCN9A	0.0234
6104	Dimethylaniline monooxygenase [N-oxide-forming] 1	FMO1	0.023
6176	UDP-glucuronosyltransferase 1-3	UGT1A3	0.0228
146	Androgen receptor	AR	0.0224
614	Progesterone receptor	PGR	0.0223
6020	Aldehyde oxidase	AOX1	0.022
6101	Dimethylaniline monooxygenase [N-oxide-forming] 3	FMO3	0.0217
3804	Sodium channel protein type 4 subunit alpha	SCN4A	0.0213
215	Sodium channel protein type 11 subunit alpha	SCN11A	0.0211
3802	Sodium channel protein type 2 subunit alpha	SCN2A	0.0211
1108	Calpastatin	CAST	0.0211
1089	Cartilage oligomeric matrix protein	COMP	0.0211
6133	Sodium channel subunit beta-2	SCN2B	0.021
6135	Sodium channel subunit beta-4	SCN4B	0.021
6127	Carbonic anhydrase-related protein	CA8	0.021
6129	Carbonic anhydrase-related protein 11	CA11	0.021
6134	Sodium channel subunit beta-3	SCN3B	0.021
6132	Sodium channel subunit beta-1	SCN1B	0.021
6128	Carbonic anhydrase-related protein 10	CA10	0.021
777	Tumor necrosis factor	TNF	0.0208
432	D(4) dopamine receptor	DRD4	0.0201
1632	Solute carrier organic anion transporter family member 2B1	SLCO2B1	0.0201
204	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE5A	0.02
6124	Carbonic anhydrase 5B, mitochondrial	CA5B	0.0197
844	Epidermal growth factor receptor	EGFR	0.0193
6131	Carbonic anhydrase 14	CA14	0.0192
198	Sodium channel protein type 10 subunit alpha	SCN10A	0.019
462	Intermediate conductance calcium-activated potassium channel protein 4	KCNN4	0.019
3803	Sodium channel protein type 3 subunit alpha	SCN3A	0.0185
6130	Carbonic anhydrase 13	CA13	0.0184
1010	Cytochrome P450 51A1	CYP51A1	0.0184
4148	Serine/threonine-protein kinase mTOR	MTOR	0.0183
385	Potassium-transporting ATPase alpha chain 1	ATP4A	0.0183
6122	Carbonic anhydrase 3	CA3	0.018
741	Potassium voltage-gated channel subfamily KQT member 1	KCNQ1	0.0179
6123	Carbonic anhydrase 5A, mitochondrial	CA5A	0.0178
6158	Solute carrier organic anion transporter family member 1C1	SLCO1C1	0.0171
580	Gamma-aminobutyric-acid receptor subunit alpha-3	GABRA3	0.017
423	Gamma-aminobutyric-acid receptor subunit alpha-2	GABRA2	0.017
485	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	PDE3A	0.0169
6126	Carbonic anhydrase 7	CA7	0.0166
6014	Cytochrome P450 2A13	CYP2A13	0.0165
504	Mast/stem cell growth factor receptor	KIT	0.0165
124	Histamine H2 receptor	HRH2	0.0164
567	Receptor tyrosine-protein kinase erbB-2	ERBB2	0.0164
631	3-hydroxy-3-methylglutaryl-coenzyme A reductase	HMGCR	0.0162
3387	3-hydroxy-3-methylglutaryl-coenzyme A reductase	mvaA	0.0162
3007	Carbonic anhydrase 12	CA12	0.0157
4205	Carbonic anhydrase 9	CA9	0.0157
592	Carbonic anhydrase 4	CA4	0.0156
818	50S ribosomal protein L10	rplJ	0.0152
1284	Nuclear receptor subfamily 1 group I member 2	NR1I2	0.0152
4099	Gamma-aminobutyric-acid receptor subunit beta-3	GABRB3	0.0151
806	Sodium/potassium-transporting ATPase alpha-1 chain	ATP1A1	0.015
436	5-hydroxytryptamine 2B receptor	HTR2B	0.0149
1517	Beta-3 adrenergic receptor	ADRB3	0.0149
2449	Tubulin alpha-3 chain	TUBA1A	0.0148
4604	Liver carboxylesterase 1	CES1	0.0147
1539	Oligopeptide transporter, small intestine isoform	SLC15A1	0.0144
2499	Tubulin beta-2C chain	TUBB2C	0.0144
716	5-hydroxytryptamine 7 receptor	HTR7	0.0144
474	Acetylcholinesterase	ACHE	0.0141
6025	UDP-glucuronosyltransferase 1-4	UGT1A4	0.0141
523	Gamma-aminobutyric-acid receptor subunit alpha-5	GABRA5	0.0139
228	Beta platelet-derived growth factor receptor	PDGFRB	0.0139
1178	Adenosine A2a receptor	ADORA2A	0.0138
1024	Solute carrier family 22 member 11	SLC22A11	0.0135
16	Adenosine A1 receptor	ADORA1	0.0134
243	Ribosyldihydronicotinamide dehydrogenase [quinone]	NQO2	0.013
26	Vascular endothelial growth factor receptor 3	FLT4	0.013
122	P2Y purinoceptor 12	P2RY12	0.0129
163	D(1B) dopamine receptor	DRD5	0.0127
596	3-oxo-5-alpha-steroid 4-dehydrogenase 1	SRD5A1	0.0126
2132	Protein S100-B	S100B	0.0126
3947	Xanthine dehydrogenase/oxidase	XDH	0.0125
32	Vascular endothelial growth factor receptor 1	FLT1	0.0124
811	Translocator protein	TSPO	0.0124
4120	NADPH--cytochrome P450 reductase	POR	0.0123
407	Vascular endothelial growth factor receptor 2	KDR	0.0123
6137	Multidrug resistance-associated protein 6	ABCC6	0.0123
613	Atrial natriuretic peptide receptor A	NPR1	0.0122
142	Gamma-aminobutyric-acid receptor subunit rho-1	GABRR1	0.0122
605	Fumarate reductase flavoprotein subunit	frdA	0.0121
2709	Fumarate reductase flavoprotein subunit	SO_0970	0.0121
3673	Fumarate reductase flavoprotein subunit	fccA	0.0121
4912	Fumarate reductase flavoprotein subunit	ifcA	0.0121
6549	Fumarate reductase flavoprotein subunit	frdA	0.0121
952	Dipeptidyl peptidase 4	DPP4	0.0121
241	Calcium-transporting ATPase type 2C member 1	ATP2C1	0.0121
238	Peroxisome proliferator-activated receptor gamma	PPARG	0.012
706	Glutamate [NMDA] receptor subunit 3A	GRIN3A	0.0119
161	Tubulin beta chain	TUBB	0.0119
312	Tubulin beta chain	TUB2	0.0119
530	Gamma-aminobutyric-acid receptor subunit alpha-4	GABRA4	0.0118
357	Carbonic anhydrase 2	CA2	0.0118
841	Gamma-aminobutyric-acid receptor subunit alpha-6	GABRA6	0.0117
6154	Multidrug and toxin extrusion protein 1	SLC47A1	0.0116
1256	5-hydroxytryptamine 6 receptor	HTR6	0.0116
48	Pyridoxal kinase	PDXK	0.0116
869	Estrogen receptor beta	ESR2	0.0115
642	3-oxo-5-alpha-steroid 4-dehydrogenase 2	SRD5A2	0.0115
6141	Sodium/bile acid cotransporter	SLC10A1	0.0115
1192	Sulfotransferase 1A1	SULT1A1	0.0113
29	Tubulin beta-1 chain	TUBB1	0.0111
4100	Gamma-aminobutyric-acid receptor subunit beta-2	GABRB2	0.011
2112	Toll-like receptor 9	TLR9	0.0109
1656	CYP2B protein	CYP2B	0.0109
6136	Multidrug resistance-associated protein 5	ABCC5	0.0109
6087	Gamma-aminobutyric acid receptor subunit gamma-1	GABRG1	0.0107
6093	Gamma-aminobutyric acid receptor subunit delta	GABRD	0.0107
6089	Gamma-aminobutyric acid receptor subunit epsilon	GABRE	0.0107
4237	50S ribosomal protein L22	rplV	0.0106
147	Aldehyde dehydrogenase, mitochondrial	ALDH2	0.0105
610	Calcium-activated potassium channel subunit alpha 1	KCNMA1	0.0104
4098	Gamma-aminobutyric-acid receptor subunit beta-1	GABRB1	0.0103
950	Alpha platelet-derived growth factor receptor	PDGFRA	0.0103
5934	Cytochrome P450 26A1	CYP26A1	0.0103
17	Proto-oncogene tyrosine-protein kinase ABL1	ABL1	0.0102
6038	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6H	0.01
768	FK506-binding protein 1A	FKBP1A	0.01
6177	UDP-glucuronosyltransferase 1-10	UGT1A10	0.0099
1757	Myeloperoxidase	MPO	0.0099
80	Peroxisome proliferator-activated receptor alpha	PPARA	0.0097
6086	Gamma-aminobutyric acid receptor subunit gamma-2	GABRG2	0.0097
3932	Glutathione S-transferase A2	GSTA2	0.0097
958	Insulin-like growth factor 1 receptor	IGF1R	0.0097
6090	Gamma-aminobutyric acid receptor subunit pi	GABRP	0.0097
6088	Gamma-aminobutyric acid receptor subunit gamma-3	GABRG3	0.0097
6115	Gamma-aminobutyric acid receptor subunit rho-3	GABRR3	0.0097
6092	Gamma-aminobutyric acid receptor subunit rho-2	GABRR2	0.0096
813	Neuronal acetylcholine receptor subunit alpha-2	CHRNA2	0.0095
6150	Solute carrier organic anion transporter family member 4C1	SLCO4C1	0.0094
4238	50S ribosomal protein L4	rplD	0.0094
5578	50S ribosomal protein L4	rplD	0.0094
6173	50S ribosomal protein L4	rplD	0.0094
6219	50S ribosomal protein L4	rplD	0.0094
6091	Gamma-aminobutyric acid receptor subunit theta	GABRQ	0.0094
6037	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6G	0.0093
373	Transthyretin	TTR	0.0093
814	Ryanodine receptor 1	RYR1	0.009
273	Apoptosis regulator Bcl-2	BCL2	0.009
427	Substance-P receptor	TACR1	0.009
4228	Keratin, type II cytoskeletal 7	KRT7	0.009
6079	Neuronal acetylcholine receptor subunit alpha-3	CHRNA3	0.0089
4203	Histamine N-methyltransferase	HNMT	0.0089
4122	Histone deacetylase 2	HDAC2	0.0088
6180	UDP-glucuronosyltransferase 2B4	UGT2B4	0.0088
1638	Solute carrier family 2, facilitated glucose transporter member 2	SLC2A2	0.0088
259	Microsomal triglyceride transfer protein large subunit	MTTP	0.0087
723	Cytosolic phospholipase A2	PLA2G4A	0.0087
6181	UDP-glucuronosyltransferase 1-8	UGT1A8	0.0087
131	Synaptic vesicular amine transporter	SLC18A2	0.0086
528	5-hydroxytryptamine 1E receptor	HTR1E	0.0085
790	DNA polymerase subunit alpha B	POLA2	0.0084
541	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	PDE4B	0.0084
33	Cystine/glutamate transporter	SLC7A11	0.0084
70	Type-1 angiotensin II receptor	AGTR1	0.0081
787	Vitamin K epoxide reductase complex subunit 1	VKORC1	0.0081
565	Extracellular calcium-sensing receptor	CASR	0.008
1353	DNA topoisomerase 1	TOP1	0.008
3552	DNA topoisomerase 1	topA	0.008
1852	Microtubule-associated protein 2	MAP2	0.0079
165	FL cytokine receptor	FLT3	0.0079
6102	Arylamine N-acetyltransferase 2	NAT2	0.0079
6078	Neuronal acetylcholine receptor subunit beta-4	CHRNB4	0.0079
705	Glutamate receptor 1	GRIA1	0.0079
173	Toll-like receptor 7	TLR7	0.0079
571	Melatonin receptor type 1A	MTNR1A	0.0078
362	Melatonin receptor type 1B	MTNR1B	0.0078
5251	Carbonyl reductase [NADPH] 1	CBR1	0.0077
244	Angiotensin-converting enzyme	ACE	0.0076
4311	tRNA	TRDMT1	0.0076
4325	tRNA	trmD	0.0076
4328	tRNA	trmD	0.0076
239	Coagulation factor X	F10	0.0076
1050	Bile salt sulfotransferase	SULT2A1	0.0076
2539	Tubulin alpha-1 chain	TUBA4A	0.0076
1629	Transcription factor AP-1	JUN	0.0076
2222	Equilibrative nucleoside transporter 1	SLC29A1	0.0074
6766	O-GlcNAcase BT_4395	BT_4395	0.0074
208	DNA-directed RNA polymerase beta' chain	rpoC	0.0074
5774	DNA-directed RNA polymerase beta' chain	rpoC	0.0074
6169	ATP-binding cassette sub-family A member 5	ABCA5	0.0073
698	B-Raf proto-oncogene serine/threonine-protein kinase	BRAF	0.0072
1974	Oligopeptide transporter, kidney isoform	SLC15A2	0.0071
6931	Calcium-activated potassium channel subunit beta-1	KCNMB1	0.0071
6933	Calcium-activated potassium channel subunit beta-4	KCNMB4	0.0071
6932	Calcium-activated potassium channel subunit beta-3	KCNMB3	0.0071
6936	Small conductance calcium-activated potassium channel protein 3	KCNN3	0.0071
6934	Small conductance calcium-activated potassium channel protein 1	KCNN1	0.0071
6935	Small conductance calcium-activated potassium channel protein 2	KCNN2	0.007
68	Cannabinoid receptor 1	CNR1	0.007
738	Monocarboxylate transporter 1	SLC16A1	0.0069
464	Glutamate [NMDA] receptor subunit epsilon-2	GRIN2B	0.0069
6043	Putative G-protein coupled receptor 44	GPR44	0.0069
823	Fibroblast growth factor receptor 2	FGFR2	0.0068
84	Nuclear receptor 0B1	NR0B1	0.0067
976	Platelet glycoprotein IX	GP9	0.0066
606	Cytochrome P450 27, mitochondrial	CYP27A1	0.0065
1714	Mitogen-activated protein kinase 3	MAPK3	0.0064
1820	Beta-nerve growth factor	NGF	0.0064
102	DNA topoisomerase I, mitochondrial	TOP1MT	0.0063
6068	Guanylate cyclase soluble subunit alpha-2	GUCY1A2	0.0063
3432	Multidrug-efflux transporter 1 regulator	bmrR	0.0063
284	DNA-directed RNA polymerase beta chain	rpoB	0.0063
5773	DNA-directed RNA polymerase beta chain	rpoB	0.0063
4476	Mannitol dehydrogenase	mtlD	0.0063
6040	6-phosphogluconate dehydrogenase, decarboxylating	PGD	0.0063
4177	Proto-oncogene tyrosine-protein kinase receptor ret	RET	0.0063
4095	Neuronal acetylcholine receptor subunit alpha-7	CHRNA7	0.0062
947	Neuronal acetylcholine receptor subunit alpha-4	CHRNA4	0.0062
6105	3-oxo-5-beta-steroid 4-dehydrogenase	AKR1D1	0.0062
511	5-hydroxytryptamine 1F receptor	HTR1F	0.0062
1502	Peroxisome proliferator-activated receptor delta	PPARD	0.0062
6044	Serum paraoxonase/lactonase 3	PON3	0.0061
1787	Nuclear factor NF-kappa-B p105 subunit	NFKB1	0.0061
6153	Solute carrier organic anion transporter family member 4A1	SLCO4A1	0.0061
319	Opioid receptor, sigma 1	OPRS1	0.006
5463	Calcium-activated potassium channel subunit beta 2	KCNMB2	0.006
7	Nitric oxide synthase, inducible	NOS2	0.006
185	Vasopressin V1a receptor	AVPR1A	0.006
820	Glycine receptor subunit alpha-2	GLRA2	0.0059
951	Macrophage colony-stimulating factor 1 receptor	CSF1R	0.0059
458	Neuronal acetylcholine receptor subunit alpha-10	CHRNA10	0.0059
904	Glutathione S-transferase P	GSTP1	0.0059
5923	Microtubule-associated protein tau	MAPT	0.0059
5924	Microtubule-associated protein 4	MAP4	0.0059
322	Vasopressin V2 receptor	AVPR2	0.0058
4103	Proteasome subunit beta type 2	PSMB2	0.0058
4102	Proteasome subunit beta type 5	PSMB5	0.0058
4101	Proteasome subunit beta type 1	PSMB1	0.0058
230	ATP-binding cassette transporter sub-family C member 8	ABCC8	0.0057
6506	Stathmin-4	STMN4	0.0055
4773	Deoxycytidine kinase	DCK	0.0055
461	Glycine receptor subunit alpha-3	GLRA3	0.0055
780	Retinoic acid receptor RXR-gamma	RXRG	0.0055
54	Prothrombin	F2	0.0054
856	Vitamin D3 receptor	VDR	0.0054
4192	DNA topoisomerase 2-beta	TOP2B	0.0053
6432	Transporter	snf	0.0053
6146	High affinity copper uptake protein 1	SLC31A1	0.0053
5998	Toll-like receptor 8	TLR8	0.0053
365	Dihydrofolate reductase	DHFR	0.0052
2381	Dihydrofolate reductase	DFR1	0.0052
2833	Dihydrofolate reductase	Not Available	0.0052
2931	Dihydrofolate reductase	folA	0.0052
3544	Dihydrofolate reductase	folA	0.0052
3682	Dihydrofolate reductase	folA	0.0052
6642	Dihydrofolate reductase	folA	0.0052
6756	Dihydrofolate reductase	dfrA	0.0052
6339	Ig kappa chain V-II region RPMI 6410	Not Available	0.0052
712	Tubulin alpha chain	TUB1	0.0052
5300	Antigen peptide transporter 1	TAP1	0.0051
275	Arachidonate 5-lipoxygenase	ALOX5	0.0051
1618	High affinity nerve growth factor receptor	NTRK1	0.0051
620	Bifunctional dihydrofolate reductase-thymidylate synthase	Not Available	0.0051
40	RAF proto-oncogene serine/threonine-protein kinase	RAF1	0.0051
4199	Sphingosine 1-phosphate receptor Edg-8	S1PR5	0.005
174	Sigma 1-type opioid receptor	SIGMAR1	0.005
88	Retinoic acid receptor RXR-beta	RXRB	0.0049
564	Cellular retinoic acid-binding protein 1	CRABP1	0.0049
1483	Membrane copper amine oxidase	AOC3	0.0048
937	Proto-oncogene tyrosine-protein kinase LCK	LCK	0.0048
6206	DNA-directed RNA polymerase subunit beta'	rpoC	0.0048
360	Ribonucleoside-diphosphate reductase large subunit	RRM1	0.0048
3856	Fibroblast growth factor receptor 3	FGFR3	0.0048
3854	Basic fibroblast growth factor receptor 1	FGFR1	0.0048
1176	Mitogen-activated protein kinase 1	MAPK1	0.0047
3957	Adenosine deaminase	ADA	0.0047
859	Cellular retinoic acid-binding protein 2	CRABP2	0.0047
2616	Ganglioside GM2 activator	GM2A	0.0047
683	Potassium transporter	GK0582	0.0047
1759	85 kDa calcium-independent phospholipase A2	PLA2G6	0.0046
1770	Phospholipase C	PLCL1	0.0046
2841	Phospholipase C	plc	0.0046
1525	Heparin-binding growth factor 2	FGF2	0.0046
3086	Plasmepsin-2	Not Available	0.0046
6085	Fatty acid-binding protein, intestinal	FABP2	0.0045
569	Retinal dehydrogenase 2	ALDH1A2	0.0045
522	26S proteasome non-ATPase regulatory subunit 2	PSMD2	0.0044
935	Proto-oncogene tyrosine-protein kinase Yes	YES1	0.0044
515	26S proteasome non-ATPase regulatory subunit 1	PSMD1	0.0044
1063	Signal transducer and activator of transcription 5B	STAT5B	0.0044
933	Proto-oncogene tyrosine-protein kinase Src	SRC	0.0044
1457	Long-chain-fatty-acid--CoA ligase 4	ACSL4	0.0044
918	Glutamate receptor, ionotropic kainate 2	GRIK2	0.0044
117	Sterol O-acyltransferase 1	SOAT1	0.0043
482	Glycine receptor subunit alpha-1	GLRA1	0.0043
106	Cannabinoid receptor 2	CNR2	0.0043
936	Ephrin type-A receptor 2	EPHA2	0.0043
6138	Multidrug resistance protein 3	ABCB4	0.0043
217	Estradiol 17-beta-dehydrogenase 1	HSD17B1	0.0042
714	Glutathione reductase, mitochondrial	GSR	0.0042
2038	Inhibitor of nuclear factor kappa-B kinase subunit beta	IKBKB	0.0042
1196	Complement decay-accelerating factor	CD55	0.0042
611	Retinal dehydrogenase 1	ALDH1A1	0.0042
1630	Integrin beta-2	ITGB2	0.0041
581	Cytochrome P450 2R1	CYP2R1	0.0041
1374	Natriuretic peptides B	NPPB	0.0041
1827	Gap junction alpha-1 protein	GJA1	0.0041
1908	Vascular cell adhesion protein 1	VCAM1	0.0041
153	Dopamine beta-hydroxylase	DBH	0.0041
3997	Cytochrome P450 24A1, mitochondrial	CYP24A1	0.0041
73	Prostaglandin E2 receptor, EP1 subtype	PTGER1	0.004
6032	PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE)	fas	0.004
921	Glutamate receptor 2	GRIA2	0.004
162	Retinoic acid receptor gamma-1	RARG	0.004
2236	Casein kinase II subunit alpha	CSNK2A1	0.004
3426	Glutamine synthetase	glnA	0.0039
3987	Glutamine synthetase	GLUL	0.0039
2268	Cholesterol oxidase	choB	0.0039
2822	Cholesterol oxidase	choA	0.0039
6098	Potassium voltage-gated channel subfamily D member 2	KCND2	0.0039
6099	Potassium voltage-gated channel subfamily D member 3	KCND3	0.0039
4146	Phosphatidylinositol 3-kinase regulatory subunit gamma	PIK3R3	0.0039
291	Nitric-oxide synthase, endothelial	NOS3	0.0039
4145	Phosphatidylinositol 3-kinase regulatory subunit beta	PIK3R2	0.0039
2184	Cystic fibrosis transmembrane conductance regulator	CFTR	0.0039
934	Proto-oncogene tyrosine-protein kinase Fyn	FYN	0.0039
1129	C-C chemokine receptor type 5	CCR5	0.0039
484	Tyrosine-protein kinase ABL2	ABL2	0.0039
908	Glutathione S-transferase theta-1	GSTT1	0.0039
719	Retinoic acid receptor responder protein 1	RARRES1	0.0038
770	Retinoic acid-induced protein 3	GPRC5A	0.0038
6824	Tyrosine-protein kinase Lyn	LYN	0.0038
1569	G1/S-specific cyclin-D1	CCND1	0.0038
183	Vascular endothelial growth factor A	VEGFA	0.0037
992	Protein tyrosine kinase 2 beta	PTK2B	0.0037
891	Dihydropteroate synthase	folP	0.0037
5359	Dihydropteroate synthase	folP	0.0037
7175	Dihydropteroate synthase	sulI	0.0037
2283	Steroid Delta-isomerase	ksi	0.0037
2920	Steroid Delta-isomerase	ksi	0.0037
2808	Chloramphenicol acetyltransferase 3	cat3	0.0036
634	Squalene monooxygenase	SQLE	0.0036
7196	Squalene monooxygenase	ERG1	0.0036
3809	Estrogen-related receptor gamma	ESRRG	0.0036
2157	NAD(P)H dehydrogenase [quinone] 1	NQO1	0.0036
734	D1 dopamine receptor-interacting protein calcyon	CALY	0.0036
543	Penicillin-binding protein 1B	mrcB	0.0035
6186	Penicillin-binding protein 1B	ponB	0.0035
6822	Penicillin-binding protein 1b	pbp1b	0.0035
6844	Penicillin-binding protein 1b	pbp1b	0.0035
1864	RET proto-oncogene	RET	0.0035
1950	Epithelial discoidin domain-containing receptor 1	DDR1	0.0035
6170	ATP-binding cassette sub-family A member 3	ABCA3	0.0035
6094	BCR/ABL fusion protein isoform X9	BCR/ABL fusion	0.0035
276	Sodium- and chloride-dependent GABA transporter 1	SLC6A1	0.0035
778	Cysteinyl leukotriene receptor 1	CYSLTR1	0.0035
194	NADH dehydrogenase [ubiquinone] 1 subunit C2	NDUFC2	0.0035
159	Penicillin-binding protein 2B	penA	0.0035
6121	Penicillin-binding protein 2B	penA	0.0035
939	50S ribosomal protein L3	rplC	0.0035
2325	Sulfotransferase family cytosolic 2B member 1	SULT2B1	0.0034
6179	UDP-glucuronosyltransferase 2B17	UGT2B17	0.0033
1281	Phosphatidylinositol 3-kinase regulatory subunit alpha	PIK3R1	0.0033
267	Plasminogen activator inhibitor 1	SERPINE1	0.0033
3601	Dihydropteroate synthase 1	folP1	0.0033
3807	Dihydropteroate synthase 1	folP1	0.0033
3808	Dihydropteroate synthase 2	folP2	0.0033
2417	Chloramphenicol acetyltransferase	cat	0.0033
3278	Chloramphenicol acetyltransferase	cat	0.0033
2810	Dr hemagglutinin structural subunit	draA	0.0032
6174	50S ribosomal protein L32	rpmF	0.0032
2450	Tyrosine-protein kinase ITK/TSK	ITK	0.0032
2718	Chloramphenicol 3-O phosphotransferase	Not Available	0.0032
476	RAC-alpha serine/threonine-protein kinase	AKT1	0.0032
1086	Potassium voltage-gated channel subfamily KQT member 2	KCNQ2	0.0032
650	Aldo-keto reductase family 1 member C3	AKR1C3	0.0032
2107	Microtubule-associated protein 1A	MAP1A	0.0032
24	Thymidylate synthase	TMP1	0.0032
359	Thymidylate synthase	TYMS	0.0032
2626	Thymidylate synthase	thyA	0.0032
2729	Thymidylate synthase	thyA	0.0032
5352	Thymidylate synthase	THYA	0.0032
140	30S ribosomal protein S9	rpsI	0.0031
6719	30S ribosomal protein S9	rpsI	0.0031
6725	30S ribosomal protein S9	rpsI	0.0031
280	4-aminobutyrate aminotransferase, mitochondrial	ABAT	0.0031
990	Dual specificity mitogen-activated protein kinase kinase 1	MAP2K1	0.0031
1636	Trace amine-associated receptor 1	TAAR1	0.0031
3913	Glutamic acid decarboxylase	GAD65	0.0031
3868	Calcineurin subunit B isoform 2	PPP3R2	0.0031
421	Calcium signal-modulating cyclophilin ligand	CAMLG	0.0031
572	Integrin alpha-L	ITGAL	0.0031
5787	Angiopoietin-1 receptor	TEK	0.0031
200	Carnitine O-palmitoyltransferase 2, mitochondrial	CPT2	0.0031
451	Carnitine O-palmitoyltransferase I, liver isoform	CPT1A	0.0031
2578	Tubulin beta-3 chain	TUBB3	0.003
2285	Streptogramin A acetyltransferase	vatD	0.003
6080	Neuronal acetylcholine receptor subunit alpha-5	CHRNA5	0.003
6082	Neuronal acetylcholine receptor subunit beta-3	CHRNB3	0.003
948	Neuronal acetylcholine receptor subunit beta-2	CHRNB2	0.003
6221	Steroid hormone receptor ERR1	ESRRA	0.0029
3610	Thioredoxin reductase 1, cytoplasmic	TXNRD1	0.0029
164	Histamine H4 receptor	HRH4	0.0029
268	Adenosine A2b receptor	ADORA2B	0.0029
1992	Vitamin D-binding protein	GC	0.0029
1275	Estrogen sulfotransferase	SULT1E1	0.0029
512	DNA-directed RNA polymerase alpha chain	rpoA	0.0029
5772	DNA-directed RNA polymerase alpha chain	rpoA	0.0029
1435	Synaptic vesicle glycoprotein 2A	SV2A	0.0028
518	Peroxidase/catalase T	katG	0.0028
6081	Neuronal acetylcholine receptor subunit alpha-6	CHRNA6	0.0028
3876	Aromatic-L-amino-acid decarboxylase	DDC	0.0027
4097	Neuronal acetylcholine receptor subunit alpha-9	CHRNA9	0.0027
6232	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	GNAS	0.0027
6233	Adenylate cyclase type 2	ADCY2	0.0027
6234	Adenylate cyclase type 5	ADCY5	0.0027
4173	Tyrosine-protein kinase JAK2	JAK2	0.0027
6140	Ileal sodium/bile acid cotransporter	SLC10A2	0.0027
6167	Organic solute transporter subunit beta	OSTB	0.0027
6166	Organic solute transporter subunit alpha	OSTA	0.0027
144	Hemoglobin subunit alpha	HBA1	0.0027
3849	Insulin-like growth factor-binding protein 7	IGFBP7	0.0027
2009	Protein NOV homolog	NOV	0.0027
3847	Neuroendocrine convertase 2	PCSK2	0.0027
1949	Carboxypeptidase E	CPE	0.0027
3850	Synaptotagmin-like protein 4	SYTL4	0.0027
3848	Neuroendocrine convertase 1	PCSK1	0.0027
3846	Retinoblastoma-associated protein	RB1	0.0027
3830	Calreticulin	CALR	0.0027
563	Thyroid peroxidase	TPO	0.0026
2216	Fibroblast growth factor receptor 4	FGFR4	0.0026
3904	Alanine aminotransferase 2	GPT2	0.0026
735	Alanine aminotransferase 1	GPT	0.0026
6599	HTH-type transcriptional regulator ttgR	ttgR	0.0026
1648	Elastin	ELN	0.0026
444	Alcohol dehydrogenase 1B	ADH1B	0.0026
5997	Tumor necrosis factor ligand superfamily member 11	TNFSF11	0.0026
49	Endothelin B receptor	EDNRB	0.0026
6859	Protein S100-A4	S100A4	0.0025
251	Alcohol dehydrogenase 1A	ADH1A	0.0025
896	Glutathione S-transferase Mu 1	GSTM1	0.0025
1385	Angiotensin-converting enzyme 2	ACE2	0.0025
5880	Thrombopoietin receptor	MPL	0.0025
459	Retinoic acid receptor RXR-alpha	RXRA	0.0025
6034	Hydroxyindole O-methyltransferase	ASMT	0.0025
6035	Nuclear receptor ROR-beta	RORB	0.0025
6036	Eosinophil peroxidase	EPX	0.0025
3937	Fatty-acid amide hydrolase	FAAH	0.0025
390	Adenosine A3 receptor	ADORA3	0.0025
400	Coagulation factor IX	F9	0.0024
5461	Coagulation factor IX	F9	0.0024
578	Endothelin-1 receptor	EDNRA	0.0024
544	Potassium voltage-gated channel subfamily E member 1	KCNE1	0.0024
6039	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	PDE11A	0.0024
3810	Catechol O-methyltransferase	COMT	0.0024
1524	Peptidyl-prolyl cis-trans isomerase A	PPIA	0.0024
6700	Peptidyl-prolyl cis-trans isomerase A	ppiA	0.0024
537	ATP synthase delta chain, mitochondrial	ATP5D	0.0024
6070	Nischarin	NISCH	0.0024
5852	Type-2 angiotensin II receptor	AGTR2	0.0024
6152	Solute carrier organic anion transporter family member 2A1	SLCO2A1	0.0024
6149	Solute carrier family 22 member 10	SLC22A10	0.0023
4221	Vascular endothelial growth factor	VEGF	0.0023
5816	Cadherin-5	CDH5	0.0023
550	Amiloride-sensitive sodium channel subunit delta	SCNN1D	0.0023
27	Amiloride-sensitive sodium channel subunit beta	SCNN1B	0.0023
552	Amiloride-sensitive sodium channel subunit gamma	SCNN1G	0.0023
213	Amiloride-sensitive sodium channel subunit alpha	SCNN1A	0.0023
1830	5'-nucleotidase	NT5E	0.0023
837	Glutamate [NMDA] receptor subunit epsilon-1	GRIN2A	0.0023
822	Aldose reductase	AKR1B1	0.0023
559	NADH-ubiquinone oxidoreductase chain 1	MT-ND1	0.0023
2599	Tyrosine-protein kinase HCK	HCK	0.0022
6155	ATP-binding cassette transporter sub-family C member 11	ABCC11	0.0022
4081	Vitamin K epoxide reductase complex subunit 1-like protein 1	VKORC1L1	0.0022
604	Vitamin K-dependent protein Z	PROZ	0.0022
1262	Corticotropin-lipotropin	POMC	0.0022
707	72 kDa type IV collagenase	MMP2	0.0022
6160	Solute carrier organic anion transporter family member 3A1	SLCO3A1	0.0022
6163	Copper-transporting ATPase 2	ATP7B	0.0022
6165	Copper-transporting ATPase 1	ATP7A	0.0022
695	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	PDE10A	0.0022
765	Indoleamine 2,3-dioxygenase	IDO1	0.0022
3404	Exotoxin A	eta	0.0022
2155	Insulin-degrading enzyme	IDE	0.0022
298	Renin	REN	0.0021
517	Alcohol dehydrogenase 1C	ADH1C	0.0021
2300	Lysozyme	E	0.0021
3633	Lysozyme	R	0.0021
5597	Lysozyme	17	0.0021
2091	Endoplasmin	HSP90B1	0.0021
6211	Tubulin epsilon chain	TUBE1	0.0021
6212	Tubulin gamma-1 chain	TUBG1	0.0021
6210	Tubulin delta chain	TUBD1	0.0021
1244	Low-density lipoprotein receptor-related protein 2	LRP2	0.0021
3917	Methylenetetrahydrofolate reductase	MTHFR	0.0021
63	Malate dehydrogenase	mdh	0.0021
2329	Malate dehydrogenase	mdh	0.0021
3445	Malate dehydrogenase	mdh	0.0021
4420	Malate dehydrogenase	mdh	0.0021
4438	Malate dehydrogenase	mdh	0.0021
594	Thyroxine-binding globulin	SERPINA7	0.0021
748	5'-AMP-activated protein kinase catalytic subunit alpha-1	PRKAA1	0.002
422	Vitamin K-dependent protein C	PROC	0.002
1245	Vitamin K-dependent protein S	PROS1	0.002
4152	Superoxide dismutase [Cu-Zn]	SOD1	0.002
245	Large neutral amino acids transporter small subunit 1	SLC7A5	0.002
6893	Calcium/calmodulin-dependent protein kinase type II gamma chain	CAMK2G	0.002
633	Penicillin-binding proteins 1A/1B	pbpA	0.0019
6164	POU domain, class 5, transcription factor 1	POU5F1	0.0019
5766	NAD-dependent deacetylase sirtuin-5	SIRT5	0.0019
389	Amiloride-sensitive cation channel 2, neuronal	ACCN2	0.0019
6100	BDNF/NT-3 growth factors receptor	NTRK2	0.0019
758	Thyroid hormone receptor alpha	THRA	0.0019
473	L-lactate dehydrogenase A chain	LDHA	0.0019
65	Matrix metalloproteinase-9	Not Available	0.0019
368	Enoyl-[acyl-carrier-protein] reductase [NADH]	inhA	0.0019
3228	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0019
3678	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0019
6856	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0019
2180	3-phosphoinositide-dependent protein kinase 1	PDPK1	0.0019
4162	Potassium voltage-gated channel subfamily KQT member 3	KCNQ3	0.0018
893	[Citrate [pro-3S]-lyase] ligase	citC	0.0018
845	Pyruvate dehydrogenase [cytochrome]	poxB	0.0018
448	Vitamin K-dependent gamma-carboxylase	GGCX	0.0018
5626	Nucleoside diphosphate kinase B	NME2	0.0018
1968	ATP-sensitive inward rectifier potassium channel 12	KCNJ12	0.0018
327	Glutathione reductase	gor	0.0018
5110	Glutathione reductase	GR2	0.0018
2408	Tyrosine-protein kinase SYK	SYK	0.0018
67	Prolyl 4-hydroxylase subunit alpha-1	P4HA1	0.0017
621	Periplasmic [Fe] hydrogenase 1	Not Available	0.0017
2290	ADP-ribosyl cyclase 2	BST1	0.0017
229	Retinoic acid receptor beta	RARB	0.0017
439	Glutamate [NMDA] receptor subunit epsilon-4	GRIN2D	0.0017
760	Fibroblast growth factor 1	FGF1	0.0017
346	Thyroid hormone receptor beta-1	THRB	0.0017
730	Retinoic acid receptor alpha	RARA	0.0017
2981	Phospholipase A2, membrane associated	PLA2G2A	0.0017
78	Acetyl-CoA acetyltransferase, mitochondrial	ACAT1	0.0016
798	Osteocalcin	BGLAP	0.0016
4209	ATP-sensitive inward rectifier potassium channel 8	KCNJ8	0.0016
364	Corticosteroid 11-beta-dehydrogenase isozyme 1	HSD11B1	0.0016
1243	Cathepsin D	CTSD	0.0016
890	Niemann-Pick C1-like protein 1	NPC1L1	0.0016
838	Inosine-5'-monophosphate dehydrogenase 1	IMPDH1	0.0016
796	Inosine-5'-monophosphate dehydrogenase 2	IMPDH2	0.0016
1650	Heme carrier protein 1	SLC46A1	0.0016
3233	Bile acid receptor	NR1H4	0.0015
401	Glutamate [NMDA] receptor subunit zeta-1	GRIN1	0.0015
6755	Poliovirus receptor	PVR	0.0015
1360	Sphingomyelin phosphodiesterase	SMPD1	0.0015
3126	Poly [ADP-ribose] polymerase 1	PARP1	0.0015
702	UMP-CMP kinase	CMPK1	0.0015
982	Cocaine- and amphetamine-regulated transcript protein	CARTPT	0.0015
3611	Cytidine deaminase	cdd	0.0015
3707	Cytidine deaminase	cdd	0.0015
4211	Cytidine deaminase	CDA	0.0015
828	Phenylalanine-4-hydroxylase	PAH	0.0015
3109	Phenylalanine-4-hydroxylase	phhA	0.0015
369	Coagulation factor VII	F7	0.0015
1291	cAMP response element-binding protein	CREB1	0.0015
3844	HLA class II histocompatibility antigen, DQ(6) alpha chain	HLA-DQA2	0.0015
1939	Heat shock protein HSP 90-alpha	HSP90AA1	0.0015
139	Aldo-keto reductase family 1 member C1	AKR1C1	0.0015
5294	Nucleoside diphosphate kinase A	NME1	0.0015
1541	Metalloproteinase	mmp20	0.0014
4210	Toll-like receptor 4	TLR4	0.0014
1039	Histone deacetylase 9	HDAC9	0.0014
1760	Aminopeptidase N	ANPEP	0.0014
6843	Aminopeptidase N	pepN	0.0014
2129	Sucrase-isomaltase, intestinal	SI	0.0014
1341	Histamine H3 receptor	HRH3	0.0014
6228	Nuclear receptor coactivator 1	NCOA1	0.0013
6241	Nuclear receptor coactivator 2	NCOA2	0.0013
561	Retinol-binding protein II, cellular	RBP2	0.0013
35	Dehydrogenase/reductase SDR family member 4	DHRS4	0.0013
4073	Retinol dehydrogenase 11	RDH11	0.0013
4074	Retinol dehydrogenase 14	RDH14	0.0013
1097	Lecithin retinol acyltransferase	LRAT	0.0013
589	Retinoid-binding protein 7	RBP7	0.0013
753	Retinol-binding protein III, cellular	RBP5	0.0013
4071	Short-chain dehydrogenase/reductase 3	DHRS3	0.0013
4075	Photoreceptor outer segment all-trans retinol dehydrogenase	RDH8	0.0013
863	Cellular retinaldehyde-binding protein	RLBP1	0.0013
800	Retinol dehydrogenase 12	RDH12	0.0013
282	Interphotoreceptor retinoid-binding protein	RBP3	0.0013
651	Retinol dehydrogenase 13	RDH13	0.0013
4072	All-trans-retinol 13,14-reductase	RETSAT	0.0013
199	Monocarboxylate transporter 8	SLC16A2	0.0013
860	Nicotinamide N-methyltransferase	NNMT	0.0013
699	Nicotinic acid receptor 1	GPR109A	0.0013
928	Nicotinic acid receptor 2	GPR109B	0.0013
583	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	QPRT	0.0013
2442	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	nadC	0.0013
2459	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	nadC	0.0013
424	Dihydroorotate dehydrogenase, mitochondrial	DHODH	0.0013
6116	Gastric triacylglycerol lipase	LIPF	0.0012
182	2-oxoglutarate dehydrogenase E1 component, mitochondrial	OGDH	0.0012
630	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial	ACADSB	0.0012
3806	cGMP-dependent 3',5'-cyclic phosphodiesterase	PDE2A	0.0012
3382	Glycolipid transfer protein	GLTP	0.0012
694	Matrix protein 2	M	0.0012
2240	Cell division protein kinase 2	CDK2	0.0012
3823	Cytokine receptor common gamma chain	IL2RG	0.0012
85	Growth hormone receptor	GHR	0.0012
2297	Genome polyprotein	Not Available	0.0012
2322	Genome polyprotein	Not Available	0.0012
2694	Genome polyprotein	Not Available	0.0012
2719	Genome polyprotein	Not Available	0.0012
2860	Genome polyprotein	Not Available	0.0012
2928	Genome polyprotein	Not Available	0.0012
3160	Genome polyprotein	Not Available	0.0012
3260	Genome polyprotein	Not Available	0.0012
4783	Genome polyprotein	Not Available	0.0012
5726	Genome polyprotein	Not Available	0.0012
5779	Genome polyprotein	Not Available	0.0012
5867	Genome polyprotein	Not Available	0.0012
6253	Genome polyprotein	Not Available	0.0012
6301	Genome polyprotein	Not Available	0.0012
6380	Genome polyprotein	Not Available	0.0012
6381	Genome polyprotein	Not Available	0.0012
6437	Genome polyprotein	Not Available	0.0012
6520	Genome polyprotein	Not Available	0.0012
6521	Genome polyprotein	Not Available	0.0012
6652	Genome polyprotein	Not Available	0.0012
6734	Genome polyprotein	Not Available	0.0012
6735	Genome polyprotein	Not Available	0.0012
6736	Genome polyprotein	Not Available	0.0012
6737	Genome polyprotein	Not Available	0.0012
6738	Genome polyprotein	Not Available	0.0012
6739	Genome polyprotein	Not Available	0.0012
6744	Genome polyprotein	Not Available	0.0012
6748	Genome polyprotein	Not Available	0.0012
6894	Genome polyprotein	Not Available	0.0012
6898	Genome polyprotein	Not Available	0.0012
338	DNA polymerase	UL30	0.0012
379	DNA polymerase	UL54	0.0012
697	DNA polymerase	ORF28	0.0012
2482	DNA polymerase	43	0.0012
4104	DNA polymerase	BALF5	0.0012
997	Protein kinase C beta type	PRKCB	0.0012
1295	Fatty acid synthase	FASN	0.0012
6151	Monocarboxylate transporter 10	SLC16A10	0.0012
331	Retinol-binding protein I, cellular	RBP1	0.0012
5878	Alpha-7 nicotinic cholinergic receptor subunit	CHRFAM7A	0.0012
505	Glutamate [NMDA] receptor subunit epsilon-3	GRIN2C	0.0011
627	11-cis retinol dehydrogenase	RDH5	0.0011
640	Aldehyde dehydrogenase 1A3	ALDH1A3	0.0011
1970	Protein kinase C alpha type	PRKCA	0.0011
754	Pancreatic triacylglycerol lipase	PNLIP	0.0011
6172	ATP-binding cassette sub-family B member 8, mitochondrial	ABCB8	0.0011
6459	Glycodelin	PAEP	0.0011
170	Succinate semialdehyde dehydrogenase, mitochondrial	ALDH5A1	0.0011
2178	Metabotropic glutamate receptor 5	GRM5	0.0011
724	Interleukin-2 receptor alpha chain	IL2RA	0.0011
717	Interleukin-2 receptor subunit beta	IL2RB	0.0011
591	Glutamate [NMDA] receptor subunit 3B	GRIN3B	0.001
1810	Protein S100-A1	S100A1	0.001
6097	Protein S100-A2	S100A2	0.001
4116	Dihydropteroate synthetase	Not Available	0.001
4217	Telomerase reverse transcriptase	TERT	0.001
1144	Hepatocyte growth factor receptor	MET	0.001
66	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II	HSD3B2	0.001
493	25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	CYP27B1	0.001
2404	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PIK3CG	0.001
2207	Rhodopsin	RHO	0.001
345	Plasma retinol-binding protein	RBP4	0.001
4041	Microsomal glutathione S-transferase 2	MGST2	0.001
521	ATP-binding cassette transporter sub-family C member 9	ABCC9	0.001
2473	Tyrosine-protein kinase CSK	CSK	0.001
2398	Tyrosine-protein kinase ZAP-70	ZAP70	0.001
337	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial	NDUFS7	0.0009
214	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	NDUFS3	0.0009
803	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	NDUFS2	0.0009
6168	Solute carrier family 22 member 16	SLC22A16	0.0009
1064	DNA (cytosine-5)-methyltransferase 1	DNMT1	0.0009
132	ATP-binding cassette sub-family A member 1	ABCA1	0.0009
6861	Alcohol dehydrogenase [NADP+]	AKR1A1	0.0009
1048	Protein S100-A13	S100A13	0.0009
2226	Protein S100-A12	S100A12	0.0009
2347	Proto-oncogene serine/threonine-protein kinase Pim-1	PIM1	0.0009
6171	Solute carrier family 28 member 3	SLC28A3	0.0009
489	Monocarboxylate transporter 2	SLC16A7	0.0009
382	Glutamate receptor, ionotropic kainate 1	GRIK1	0.0008
22	30S ribosomal protein S4	rpsD	0.0008
6714	30S ribosomal protein S4	rpsD	0.0008
3616	Fatty acid-binding protein, epidermal	FABP5	0.0008
5433	UPF0230 protein TM_1468	TM_1468	0.0008
5430	Hepatocyte nuclear factor 4-gamma	HNF4G	0.0008
5431	Lipid binding protein	Not Available	0.0008
5798	Mitogen-activated protein kinase 11	MAPK11	0.0008
3961	G protein-activated inward rectifier potassium channel 4	KCNJ5	0.0008
2320	Thymidine kinase, cytosolic	TK1	0.0008
1867	Major prion protein	PRNP	0.0008
2232	Interleukin-5	IL5	0.0008
1593	Mucin-2	MUC2	0.0008
4031	Glutathione S-transferase A1	GSTA1	0.0008
500	Monocarboxylate transporter 4	SLC16A3	0.0008
1649	Small inducible cytokine A2	CCL2	0.0008
2530	Protein kinase C theta type	PRKCQ	0.0008
1025	Aquaporin-1	AQP1	0.0008
866	Large neutral amino acids transporter small subunit 2	SLC7A8	0.0007
4226	Uridine phosphorylase 2	UPP2	0.0007
6263	cAMP-dependent protein kinase catalytic subunit alpha	PRKACA	0.0007
130	Prostacyclin synthase	PTGIS	0.0007
6103	Arylamine N-acetyltransferase 1	NAT1	0.0007
1768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit	GNG2	0.0007
1268	Neuropeptide S receptor	NPSR1	0.0007
1571	G protein-activated inward rectifier potassium channel 1	KCNJ3	0.0007
1581	G protein-activated inward rectifier potassium channel 2	KCNJ6	0.0007
6218	Pannexin-1	PANX1	0.0007
6207	30S ribosomal protein S14	rpsN	0.0007
6209	30S ribosomal protein S19	rpsS	0.0007
6712	30S ribosomal protein S19	rpsS	0.0007
6726	30S ribosomal protein S19	rpsS	0.0007
283	SEC14-like protein 2	SEC14L2	0.0007
645	Penicillin-binding protein 1A	mrcA	0.0007
5805	Penicillin-binding protein 1A	ponA	0.0007
6185	Penicillin-binding protein 1A	mrcA	0.0007
6799	Penicillin-binding protein 1A	pbpA	0.0007
3587	Gastrotropin	FABP6	0.0007
2511	MAP kinase-activated protein kinase 2	MAPKAPK2	0.0007
226	Gonadotropin-releasing hormone receptor	GNRHR	0.0007
6836	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial	HIBCH	0.0007
6837	Serine/threonine-protein kinase 17B	STK17B	0.0007
4225	Uridine phosphorylase 1	UPP1	0.0007
76	Nitric-oxide synthase, brain	NOS1	0.0007
125	DNA polymerase beta	POLB	0.0007
5432	Trafficking protein particle complex subunit 3	TRAPPC3	0.0007
2211	Fatty acid-binding protein, heart	FABP3	0.0007
1123	Eosinophil cationic protein	RNASE3	0.0007
6073	Potassium channel subfamily K member 9	KCNK9	0.0006
6072	Potassium channel subfamily K member 3	KCNK3	0.0006
137	FolC bifunctional protein [Includes: Folylpolyglutamate synthase	folC	0.0006
413	Amidophosphoribosyltransferase	PPAT	0.0006
2515	Amidophosphoribosyltransferase	purF	0.0006
3714	Amidophosphoribosyltransferase	purF	0.0006
6677	Myelin P2 protein	PMP2	0.0006
342	P protein [Includes: DNA-directed DNA polymerase	P	0.0006
612	P protein [Includes: DNA-directed DNA polymerase	P	0.0006
677	Choline-phosphate cytidylyltransferase A	PCYT1A	0.0006
6656	UDP-glucuronosyltransferase 3A1	UGT3A1	0.0006
1721	Glycogen synthase kinase-3 beta	GSK3B	0.0005
3238	Multidrug resistance protein mexA	mexA	0.0005
3116	Bacterioferritin	bfr	0.0005
4906	Bacterioferritin	bfr	0.0005
4965	Bacterioferritin	bfr	0.0005
3173	Enolase	eno	0.0005
3709	Glycerol uptake facilitator protein	glpF	0.0005
3336	C4-dicarboxylate transport transcriptional regulatory protein dctD	dctD	0.0005
3393	TGF-beta receptor type-2	TGFBR2	0.0005
5489	Ribonucleoside-diphosphate reductase 1 subunit beta	nrdB	0.0005
709	ATP-sensitive inward rectifier potassium channel 1	KCNJ1	0.0005
2021	Thrombomodulin	THBD	0.0005
3639	Thymidine phosphorylase	deoA	0.0005
3936	Thymidine phosphorylase	TYMP	0.0005
3221	Cytochrome c4	cc4	0.0005
2183	Fatty acid-binding protein, adipocyte	FABP4	0.0005
1302	Dihydropyrimidine dehydrogenase [NADP+]	DPYD	0.0005
6344	ATP synthase subunit gamma, mitochondrial	ATP5C1	0.0005
6343	ATP synthase subunit beta, mitochondrial	ATP5B	0.0005
6342	ATP synthase subunit alpha, mitochondrial	ATP5A1	0.0005
2852	DNA mismatch repair protein mutL	mutL	0.0005
6002	Prostaglandin E2 receptor EP4 subtype	PTGER4	0.0005
5278	Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1	PAPSS1	0.0005
3191	Histidinol dehydrogenase	hisD	0.0005
4131	Prostaglandin E2 receptor, EP3 subtype	PTGER3	0.0004
406	Prostaglandin E2 receptor, EP2 subtype	PTGER2	0.0004
6259	(3R)-hydroxymyristoyl-acyl carrier protein dehydratase	fabZ	0.0004
4692	A/G-specific adenine glycosylase	mutY	0.0004
6161	Probable low affinity copper uptake protein 2	SLC31A2	0.0004
6042	Prostaglandin reductase 2	PTGR2	0.0004
5818	Folate receptor alpha	FOLR1	0.0004
2802	Endoglucanase G	celCCG	0.0004
340	Apoptotic protease-activating factor 1	APAF1	0.0004
2391	Ferrochelatase	hemH	0.0004
6502	Ferrochelatase	DKFZp686P18130	0.0004
1591	Ferrochelatase, mitochondrial	FECH	0.0004
6316	ADP-ribosylation factor 1	ARF1	0.0004
1792	Tissue-type plasminogen activator	PLAT	0.0004
2101	Glutathione-requiring prostaglandin D synthase	HPGDS	0.0003
293	Gamma-glutamyl hydrolase	GGH	0.0003
825	Arsenical pump-driving ATPase	ASNA1	0.0003
3435	Arsenical pump-driving ATPase	arsA	0.0003
486	Serine/threonine-protein kinase ALS2CR7	CDK15	0.0003
2105	ATP-binding cassette sub-family G member 1	ABCG1	0.0003
377	Beta-adrenergic receptor kinase 1	ADRBK1	0.0003
510	Serine/threonine-protein kinase receptor R3	ACVRL1	0.0003
733	Activin receptor type 1B	ACVR1B	0.0003
225	NEDD8-activating enzyme E1 regulatory subunit	NAE1	0.0003
745	Anti-Muellerian hormone type-2 receptor	AMHR2	0.0003
483	A-Raf proto-oncogene serine/threonine-protein kinase	ARAF	0.0003
21	Beta-adrenergic receptor kinase 2	ADRBK2	0.0003
154	AFG3-like protein 2	AFG3L2	0.0003
395	ALK tyrosine kinase receptor	Not Available	0.0003
6270	Group IIE secretory phospholipase A2	PLA2G2E	0.0003
6496	Cytochrome c oxidase subunit 8A, mitochondrial	COX8A	0.0003
6493	Cytochrome c oxidase subunit 6C	COX6C	0.0003
6495	Cytochrome c oxidase subunit 7C, mitochondrial	COX7C	0.0003
6499	Cytochrome c oxidase polypeptide 7A1, mitochondrial	COX7A1	0.0003
6494	Cytochrome c oxidase subunit 7B, mitochondrial	COX7B	0.0003
6491	Cytochrome c oxidase subunit 5A, mitochondrial	COX5A	0.0003
6498	Cytochrome c oxidase subunit 6B1	COX6B1	0.0003
6497	Cytochrome c oxidase subunit 6A2, mitochondrial	COX6A2	0.0003
6489	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	COX4I1	0.0003
5793	Cytochrome c oxidase subunit 2	MT-CO2	0.0003
6559	Cytochrome c oxidase subunit 2	ctaC	0.0003
6669	Cytochrome c oxidase subunit 2	ctaC	0.0003
6490	Cytochrome c oxidase subunit 3	MT-CO3	0.0003
371	Cytochrome c oxidase subunit 1	MT-CO1	0.0003
6558	Cytochrome c oxidase subunit 1	ctaD	0.0003
292	Activin receptor type-1	ACVR1	0.0003
849	Activated CDC42 kinase 1	TNK2	0.0003
1313	Lactoylglutathione lyase	GLO1	0.0003
773	Folylpolyglutamate synthase, mitochondrial	FPGS	0.0003
2540	Choloylglycine hydrolase	cbh	0.0003
704	Long-chain-fatty-acid--CoA ligase 1	ACSL1	0.0003
821	Acetyl-coenzyme A synthetase 2-like, mitochondrial	ACSS1	0.0003
386	Acetyl-coenzyme A synthetase, cytoplasmic	ACSS2	0.0003
297	Adenylate cyclase type 1	ADCY1	0.0003
289	Cytosolic purine 5'-nucleotidase	NT5C2	0.0003
6501	Fatty acid-binding protein, liver	FABP1	0.0003
2287	Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase	ATIC	0.0003
740	Argininosuccinate synthase	ASS1	0.0002
865	Argininosuccinate synthase	ASS1	0.0002
2680	Argininosuccinate synthase	argG	0.0002
3194	Argininosuccinate synthase	argG	0.0002
661	ADP/ATP translocase 1	SLC25A4	0.0002
6021	Adenosine kinase	ADK	0.0002
242	Asparagine synthetase [glutamine-hydrolyzing]	ASNS	0.0002
6500	Phospholipase A2	PLA2G1B	0.0002
4936	Cytochrome c2 iso-2	Not Available	0.0001
4916	Cyanoglobin	glbN	0.0001
4994	Hemoglobin-like protein HbO	glbO	0.0001
4915	Cytochrome c-550	psbV	0.0001
4959	Cytochrome c-550	psbV	0.0001
5216	Cytochrome c-550	psbV	0.0001
4925	Cytochrome c-type protein SHP	shp	0.0001
4904	Cytochrome c family protein	GSU1996	0.0001
4943	Cytochrome c6	petJ	0.0001
4954	Soluble cytochrome b558	Not Available	0.0001
4934	Cytochrome c-551	nirM	0.0001
5218	Cytochrome c-551	nirM	0.0001
4905	Cytochrome c2	Not Available	0.0001
4939	Cytochrome c2	cycA	0.0001
4964	Cytochrome c2	cycA	0.0001
4979	Cytochrome c2	cycA	0.0001
6673	Cytochrome c2	cycA	0.0001
4910	Cytoglobin	CYGB	0.0001
4984	Neuroglobin	NGB	0.0001
4981	Iron-starvation protein PigA	pigA	0.0001
4909	CooA protein	cooA	0.0001
4998	Hemoglobin-like protein yjbI	yjbI	0.0001
4935	Cytochrome c-554	cycA1	0.0001
4947	Bacterial hemoglobin	vhb	0.0001
4975	Cytochrome c-556	RPA3973	0.0001
4942	Diheme cytochrome c napB	napB	0.0001
4931	Cytochrome P450 167A1	CYP167A1	0.0001
5000	HemO	hemO	0.0001
4972	P450cin	cinA	0.0001
4960	Putative cytochrome P450-family protein	SCO7417	0.0001
4971	Nonaheme cytochrome c	hmcA	0.0001
4989	Cytochrome c551 peroxidase	ccp	0.0001
5222	Cytochrome c551 peroxidase	ccpA	0.0001
4961	Hemophore HasA	hasA	0.0001
4976	Apocytochrome f	petA	0.0001
6407	Apocytochrome f	petA	0.0001
4907	Cytochrome c-L	moxG	0.0001
6865	Cytochrome c-L	moxG	0.0001
4993	Hydroxylamine oxidoreductase	hao1	0.0001
4764	Cytochrome P450 165C4	CYP165C4	0.0001
4926	Heme-based aerotactic transducer hemAT	hemAT	0.0001
644	Heme oxygenase 2	HMOX2	0.0001
4982	Heme oxygenase 2	pbsA2	0.0001
4952	Catalase/peroxidase	katA	0.0001
4970	Cytochrome c nitrite reductase catalytic subunit	nrfA	0.0001
4937	Cytochrome oxidase subunit II	rcoxA	0.0001
4903	Methyl-accepting chemotaxis protein	Tar4	0.0001
4999	Cytochrome P450 165B3	CYP165B3	0.0001
3093	Catalase HPII	katE	0.0001
4908	Heme-regulated cyclic AMP phosphodiesterase	dosP	0.0001
4922	Cytochrome c, putative	SO_4144	0.0001
4920	Peroxidase/catalase	katG	0.0001
4990	PpcA	ppcA	0.0001
4948	Cytochrome c-553	Not Available	0.0001
4923	Cytochrome c3	DvMF_2499	0.0001
4945	Cytochrome c3	Not Available	0.0001
4949	Cytochrome c3	DVU_3171	0.0001
4968	Cytochrome c3	cytc3	0.0001
4997	Cytochrome c3	SO_2727	0.0001
5219	Cytochrome c3	cyd	0.0001
2119	Cytochrome b5	CYB5A	0.0001
4902	Nine-heme cytochrome c	Ddes_2038	0.0001
3189	High-molecular-weight cytochrome c	hmcA	0.0001
4956	Quinohemoprotein alcohol dehydrogenase ADH IIB	qbdA	0.0001
3375	Acidic cytochrome c3	Not Available	0.0001
4988	Sulfite oxidase, mitochondrial	SUOX	0.0001
2915	Sensor protein fixL	fixL	0.0001
4944	Sensor protein fixL	fixL	0.0001
4813	Heme oxygenase	hmuO	0.0001
5769	Heme oxygenase	Not Available	0.0001
3570	Cytochrome P450 152A1	cypC	0.0001
4385	Cytochrome c'	Not Available	0.0001
4967	Cytochrome c'	cycA	0.0001
5038	Cytochrome c'	Not Available	0.0001
5223	Cytochrome c'	cycP	0.0001
4037	Hypothetical protein	GPX1	0.0001
4297	Hypothetical protein	SP_1951	0.0001
4521	Hypothetical protein	BC_2969	0.0001
4540	Hypothetical protein	TM_1070	0.0001
4555	Hypothetical protein	MT1739	0.0001
4569	Hypothetical protein	mshD	0.0001
4578	Hypothetical protein	PA3270	0.0001
4747	Hypothetical protein	PA3967	0.0001
5177	Hypothetical protein	TM_0096	0.0001
5194	Hypothetical protein	PA1204	0.0001
5240	Hypothetical protein	Rv2991	0.0001
5370	Hypothetical protein	TM_1158	0.0001
5710	Hypothetical protein	Tb927.5.1360	0.0001
4289	Cytochrome P450	TT_P0059	0.0001
6262	Cytochrome P450	staP	0.0001
4992	Cytochrome c peroxidase	Not Available	0.0001
2230	Catalase	CAT	0.0001
3249	Catalase	katA	0.0001
3625	Catalase	katA	0.0001
4539	Catalase	katA	0.0001
4941	Catalase	katB	0.0001
3670	Soluble cytochrome b562 precursor	cybC	0.0001
3411	Cytochrome P450 121	cyp121	0.0001
3291	Cytochrome c-552	cycA	0.0001
4927	Cytochrome c-552	nrfA	0.0001
4938	Cytochrome c-552	cycA	0.0001
4953	Cytochrome c-552	nrfA	0.0001
5217	Cytochrome c-552	cycM	0.0001
2617	Nitric oxide synthase oxygenase	nos	0.0001
2701	Nitric oxide synthase oxygenase	nos	0.0001
3102	Flavohemoprotein	hmp	0.0001
4969	Flavohemoprotein	hmp	0.0001
4386	Hemoglobin-like protein HbN	glbN	0.0001
3127	Nitrite reductase	nirS	0.0001
3284	Nitrite reductase	nirS	0.0001
2845	Bifunctional P-450:NADPH-P450 reductase	CYP102A1	0.0001
2972	6-deoxyerythronolide B hydroxylase	eryF	0.0001
4608	Putative cytochrome P450	SCO1207	0.0001
4963	Putative cytochrome P450	SCO2884	0.0001
6254	Putative cytochrome P450	SCO6998	0.0001
358	Cystathionine beta-synthase	CBS	0
1507	Cytochrome c	CYCS	0
693	Hemoglobin subunit beta	HBB	0
6268	Hydroxyacid oxidase 1	HAO1	0
810	Heme oxygenase 1	HMOX1	0
3391	Heme oxygenase 1	pbsA1	0

(*) Categorization taken from DrugBank: therapeutic category or general category of a drug (i.e. anti-convulsant, antibacterial, etc.)

DB01388 - Mibefradil

Targets

Enzymes

Transporters

Predictions