DT-Web

DB00289 - Atomoxetine


Identification
Name Atomoxetine
Accession Number DB00289 (APRD00614)
Type small molecule
Description Atomoxetine is the first non-stimulant drug approved for the treatment of attention-deficit hyperactivity disorder (ADHD). It is sold in the form of the hydrochloride salt of atomoxetine. This chemical is manufactured and marketed under the brand name Strattera; by Eli Lilly and Company and as a generic Attentin by Torrent Pharmaceuticals. There is currently no generic available within the United States due to patent restrictions. [Wikipedia]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 255.3547
Groups approved
Monoisotopic Weight 255.162314299
Pharmacology
Indication For the treatment of Attention-Deficit/Hyperactivity Disorder (ADHD) alone or in combination with behavioral treatment, as an adjunct to psychological, educational, social, and other remedial measures.
Mechanism of action The precise mechanism by which atomoxetine produces its therapeutic effects in Attention-Deficit/Hyperactivity Disorder (ADHD) is unknown, but is thought to be related to selective inhibition of the pre-synaptic norepinephrine transporter, as determined through in-vitro studies. Atomoxetine appears to have minimal affinity for other noradrenergic receptors or for other neurotransmitter transporters or receptors.
Absorption Atomoxetine is rapidly absorbed after oral administration, with absolute bioavailability of about 63% in EMs and 94% in PMs. Drugs that elevate gastric pH (magnesium hydroxide/aluminum hydroxide, omeprazole) have no effect on atomoxetine bioavailability. Absorption is minimally affected by food.
Protein binding At therapeutic concentrations, 98% of atomoxetine in plasma is bound to protein, primarily albumin.
Biotransformation Atomoxetine is primarily metabolized by the CYP2D6 pathway to 4-hydroxyatomoxetine. 4-Hydroxyatomoxetine is equipotent to atomoxetine as an inhibitor of the norepinephrine transporter but circulates in plasma at much lower concentrations (1% of atomoxetine concentration in EMs and 0.1% of atomoxetine concentration in PMs).
Route of elimination Not Available
Toxicity The most commonly reported symptoms accompanying acute and chronic overdoses are somnolence, agitation, hyperactivity, abnormal behavior, and gastrointestinal symptoms.
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Amiodarone The CYP2D6 inhibitor could increase the effect and toxicity of atomoxetine
Chloroquine The CYP2D6 inhibitor could increase the effect and toxicity of atomoxetine
Cocaine CYP2D6 Inhibitors (Strong) such as cocaine may increase the serum concentration of atomoxetine. Initiate atomoxetine at a reduced dose (patients up to 70kg: 0.5mg/kg/day; patients 70kg or more: 40mg/day) in patients receiving a strong CYP2D6 inhibitor. The dose should only be increased to usual doses if symptoms fail to improve after 4 weeks. Patients established on atomoxetine therapy may require dosage reductions and should be monitored for increased levels/adverse effects with initiation/dose increase of a strong CYP2D6 inhibitor.
Diphenhydramine Diphenhydramine, a moderate CYP2D6 inhibitor, may increase the therapeutic and adverse effects of atomoxetine by decreasing its metabolism.
Fluoxetine The CYP2D6 inhibitor could increase the effect and toxicity of atomoxetine
Fluphenazine Risk of additive CNS depressant effects. Monitor for increased CNS depression during concomitant therapy.
Haloperidol The CYP2D6 inhibitor could increase the effect and toxicity of atomoxetine
Isocarboxazid Possible severe adverse reaction with this combination
Lomustine The CYP2D6 inhibitor could increase the effect and toxicity of atomoxetine
Mibefradil The CYP2D6 inhibitor could increase the effect and toxicity of atomoxetine
Paroxetine The CYP2D6 inhibitor, paroxetine, may increase the effect and toxicity of atomoxetine.
Perphenazine The CYP2D6 inhibitor could increase the effect and toxicity of atomoxetine
Phenelzine Possible severe adverse reaction with this combination
Propoxyphene The CYP2D6 inhibitor could increase the effect and toxicity of atomoxetine
Quinacrine The CYP2D6 inhibitor could increase the effect and toxicity of atomoxetine
Quinidine The CYP2D6 inhibitor could increase the effect and toxicity of atomoxetine
Quinidine barbiturate The CYP2D6 inhibitor could increase the effect and toxicity of atomoxetine
Quinine The CYP2D6 inhibitor could increase the effect and toxicity of atomoxetine
Rasagiline Possible severe adverse reaction with this combination
Ritonavir The CYP2D6 inhibitor could increase the effect and toxicity of atomoxetine
Terbinafine Terbinafine, a CYP2D6 inhibitor, may reduce the metabolism and clearance of Atomoxetine. Consider alternate therapy or monitor for therapeutic/adverse effects of Atomoxetine if Terbinafine is initiated, discontinued or dose changed.
Thioridazine The CYP2D6 inhibitor could increase the effect and toxicity of atomoxetine
Tranylcypromine The MAO inhibitor, Tranylcypromine, may increase the central neurotoxic effects of the Atomoxetine. These agents should not be administered within 14 days of each other.
Triprolidine The CNS depressants, Triprolidine and Atomoxetine, may increase adverse/toxic effects due to additivity. Monitor for increased CNS depressant effects during concomitant therapy.
Vinorelbine The CYP2D6 inhibitor could increase the effect and toxicity of atomoxetine
Yohimbine The CYP2D6 inhibitor could increase the effect and toxicity of atomoxetine
Food Interactions
  • Take without regard to meals.
  • In the presence of food, the absorption rate is reduced, without the quantity absorbed being affected.

Targets


Sodium-dependent noradrenaline transporter
Name Sodium-dependent noradrenaline transporter
Gene Name SLC6A2
Pharmacological action yes
Actions Not Available
References
  • Biederman J, Heiligenstein JH, Faries DE, Galil N, Dittmann R, Emslie GJ, Kratochvil CJ, Laws HF, Schuh KJ: Efficacy of atomoxetine versus placebo in school-age girls with attention-deficit/hyperactivity disorder. Pediatrics. 2002 Dec;110(6):e75. - Pubmed
  • Spencer T, Heiligenstein JH, Biederman J, Faries DE, Kratochvil CJ, Conners CK, Potter WZ: Results from 2 proof-of-concept, placebo-controlled studies of atomoxetine in children with attention-deficit/hyperactivity disorder. J Clin Psychiatry. 2002 Dec;63(12):1140-7. - Pubmed
  • Michelson D, Adler L, Spencer T, Reimherr FW, West SA, Allen AJ, Kelsey D, Wernicke J, Dietrich A, Milton D: Atomoxetine in adults with ADHD: two randomized, placebo-controlled studies. Biol Psychiatry. 2003 Jan 15;53(2):112-20. - Pubmed
  • Wernicke JF, Faries D, Girod D, Brown J, Gao H, Kelsey D, Quintana H, Lipetz R, Michelson D, Heiligenstein J: Cardiovascular effects of atomoxetine in children, adolescents, and adults. Drug Saf. 2003;26(10):729-40. - Pubmed
  • Wernicke JF, Adler L, Spencer T, West SA, Allen AJ, Heiligenstein J, Milton D, Ruff D, Brown WJ, Kelsey D, Michelson D: Changes in symptoms and adverse events after discontinuation of atomoxetine in children and adults with attention deficit/hyperactivity disorder: a prospective, placebo-controlled assessment. J Clin Psychopharmacol. 2004 Feb;24(1):30-5. - Pubmed
  • Garnock-Jones KP, Keating GM: Atomoxetine: a review of its use in attention-deficit hyperactivity disorder in children and adolescents. Paediatr Drugs. 2009;11(3):203-26. - Pubmed
  • Kaplan S, Heiligenstein J, West S, Busner J, Harder D, Dittmann R, Casat C, Wernicke JF: Efficacy and safety of atomoxetine in childhood attention-deficit/hyperactivity disorder with comorbid oppositional defiant disorder. J Atten Disord. 2004 Oct;8(2):45-52. - Pubmed
  • Purper-Ouakil D, Fourneret P, Wohl M, Reneric JP: [Atomoxetine: a new treatment for Attention Deficit/Hyperactivity Disorder (ADHD) in children and adolescents] Encephale. 2005 May-Jun;31(3):337-48. - Pubmed
  • Gaillez C, Sorbara F, Perrin E: [Atomoxetine (Strattera), an alternative in the treatment of attention-deficit/hyperactivity disorder (ADHD) in children] Encephale. 2007 Sep;33(4 Pt 1):621-8. - Pubmed
  • Tatsumi M, Groshan K, Blakely RD, Richelson E: Pharmacological profile of antidepressants and related compounds at human monoamine transporters. Eur J Pharmacol. 1997 Dec 11;340(2-3):249-58. - Pubmed
DTHybrid score 0.4793
Sodium-dependent serotonin transporter
Name Sodium-dependent serotonin transporter
Gene Name SLC6A4
Pharmacological action unknown
Actions Not Available
References
  • Tatsumi M, Groshan K, Blakely RD, Richelson E: Pharmacological profile of antidepressants and related compounds at human monoamine transporters. Eur J Pharmacol. 1997 Dec 11;340(2-3):249-58. - Pubmed
DTHybrid score 0.3682

Enzymes


Cytochrome P450 2D6
Name Cytochrome P450 2D6
Gene Name CYP2D6
Actions substrate,inhibitor
References
  • Purper-Ouakil D, Fourneret P, Wohl M, Reneric JP: [Atomoxetine: a new treatment for Attention Deficit/Hyperactivity Disorder (ADHD) in children and adolescents] Encephale. 2005 May-Jun;31(3):337-48. - Pubmed
  • Garnock-Jones KP, Keating GM: Atomoxetine: a review of its use in attention-deficit hyperactivity disorder in children and adolescents. Paediatr Drugs. 2009;11(3):203-26. - Pubmed
  • Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.4517
Cytochrome P450 2C19
Name Cytochrome P450 2C19
Gene Name CYP2C19
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.2926
Cytochrome P450 3A4
Name Cytochrome P450 3A4
Gene Name CYP3A4
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.4703

Predictions


Id Partner name Gene Name Score
4757 Cytochrome P450 2C9 CYP2C9 0.209
713 Sodium-dependent dopamine transporter SLC6A3 0.2043
1588 Multidrug resistance protein 1 ABCB1 0.1723
4200 Cytochrome P450 1A2 CYP1A2 0.1697
4118 Cytochrome P450 3A5 CYP3A5 0.1281
4924 Cytochrome P450 2C8 CYP2C8 0.1238
6030 Cytochrome P450 2B6 CYP2B6 0.1179
6013 Cytochrome P450 2E1 CYP2E1 0.0969
556 Alpha-1A adrenergic receptor ADRA1A 0.0957
6107 Cytochrome P450 3A7 CYP3A7 0.0938
492 Histamine H1 receptor HRH1 0.08
502 5-hydroxytryptamine 2A receptor HTR2A 0.0754
590 5-hydroxytryptamine 2C receptor HTR2C 0.0613
3941 Amine oxidase [flavin-containing] A MAOA 0.061
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0586
1181 Alpha-1-acid glycoprotein 1 ORM1 0.058
318 Alpha-2A adrenergic receptor ADRA2A 0.0576
6024 Cytochrome P450 1A1 CYP1A1 0.0556
5718 Cytochrome P450 2A6 CYP2A6 0.054
131 Synaptic vesicular amine transporter SLC18A2 0.0497
3939 Amine oxidase [flavin-containing] B MAOB 0.0493
587 Serum albumin ALB 0.0488
831 D(2) dopamine receptor DRD2 0.0434
632 Alpha-1B adrenergic receptor ADRA1B 0.0429
766 Beta-2 adrenergic receptor ADRB2 0.0427
320 5-hydroxytryptamine 1A receptor HTR1A 0.0408
6106 Cytochrome P450 2C18 CYP2C18 0.0391
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.039
193 Beta-1 adrenergic receptor ADRB1 0.0382
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0378
436 5-hydroxytryptamine 2B receptor HTR2B 0.0369
20 Prostaglandin G/H synthase 1 PTGS1 0.0361
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0336
6144 Solute carrier family 22 member 2 SLC22A2 0.0324
6145 Solute carrier family 22 member 1 SLC22A1 0.0321
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0317
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0302
629 Alpha-2B adrenergic receptor ADRA2B 0.03
23 D(1A) dopamine receptor DRD1 0.0298
847 Mu-type opioid receptor OPRM1 0.0297
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0294
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0284
467 Delta-type opioid receptor OPRD1 0.028
696 Kappa-type opioid receptor OPRK1 0.0263
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0262
789 Alpha-1D adrenergic receptor ADRA1D 0.0253
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0251
378 Alpha-2C adrenergic receptor ADRA2C 0.0238
118 Organic cation/carnitine transporter 2 SLC22A5 0.0234
3811 Cytochrome P450 19A1 CYP19A1 0.0225
341 5-hydroxytryptamine 3 receptor HTR3A 0.0208
731 HIV-1 protease HIV-1 protease 0.0208
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0208
862 Multidrug resistance-associated protein 1 ABCC1 0.0206
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0202
1729 Solute carrier family 22 member 6 SLC22A6 0.02
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0195
871 Glucocorticoid receptor NR3C1 0.0195
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0188
6182 Cytochrome P450 2J2 CYP2J2 0.0187
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0183
6147 Solute carrier family 22 member 3 SLC22A3 0.0181
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0176
1656 CYP2B protein CYP2B 0.0173
260 Cytochrome P450 51 ERG11 0.0171
761 Cytochrome P450 51 ERG11 0.0171
3163 Cytochrome P450 51 cyp51 0.0171
1898 Cytochrome P450 1B1 CYP1B1 0.0164
474 Acetylcholinesterase ACHE 0.0156
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0155
1636 Trace amine-associated receptor 1 TAAR1 0.0152
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0152
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0152
3923 Cholinesterase BCHE 0.0149
833 Organic cation/carnitine transporter 1 SLC22A4 0.0148
6432 Transporter snf 0.0147
885 5-hydroxytryptamine 1B receptor HTR1B 0.0144
290 Prostaglandin G/H synthase 2 PTGS2 0.0141
638 D(3) dopamine receptor DRD3 0.0141
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0141
776 Bile salt export pump ABCB11 0.0134
136 Estrogen receptor ESR1 0.0132
1517 Beta-3 adrenergic receptor ADRB3 0.0132
725 5-hydroxytryptamine 1D receptor HTR1D 0.0121
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0121
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.012
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.012
6142 Solute carrier family 22 member 8 SLC22A8 0.0113
6031 Cytochrome P450 3A43 CYP3A43 0.011
124 Histamine H2 receptor HRH2 0.0109
432 D(4) dopamine receptor DRD4 0.0108
465 Calmodulin CALM1 0.0108
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0107
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0104
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0101
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0101
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0099
817 DNA topoisomerase 2-alpha TOP2A 0.0098
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0098
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0097
146 Androgen receptor AR 0.0096
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0095
468 Cytochrome P450 4A11 CYP4A11 0.0095
232 Corticosteroid-binding globulin SERPINA6 0.0093
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0093
2164 Multidrug resistance-associated protein 4 ABCC4 0.0092
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0092
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0089
6143 Solute carrier family 22 member 7 SLC22A7 0.0088
94 5-hydroxytryptamine 4 receptor HTR4 0.0087
614 Progesterone receptor PGR 0.0086
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0086
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0086
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0085
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0085
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0084
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0081
122 P2Y purinoceptor 12 P2RY12 0.0081
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.008
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0079
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0079
161 Tubulin beta chain TUBB 0.0079
312 Tubulin beta chain TUB2 0.0079
442 Envelope glycoprotein gp41 0.0078
4859 Envelope glycoprotein env 0.0078
163 D(1B) dopamine receptor DRD5 0.0078
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0075
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0075
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0075
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0074
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0074
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0074
1757 Myeloperoxidase MPO 0.0074
716 5-hydroxytryptamine 7 receptor HTR7 0.0073
4148 Serine/threonine-protein kinase mTOR MTOR 0.0073
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0071
818 50S ribosomal protein L10 rplJ 0.0071
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0071
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0069
380 Cytochrome P450 17A1 CYP17A1 0.0067
482 Glycine receptor subunit alpha-1 GLRA1 0.0066
904 Glutathione S-transferase P GSTP1 0.0065
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0065
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0065
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0065
844 Epidermal growth factor receptor EGFR 0.0064
952 Dipeptidyl peptidase 4 DPP4 0.0064
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0064
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0063
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0063
592 Carbonic anhydrase 4 CA4 0.0062
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0061
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0061
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0061
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0061
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0061
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.006
6148 Multidrug resistance-associated protein 7 ABCC10 0.006
158 Sodium channel protein type 1 subunit alpha SCN1A 0.006
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0059
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0059
777 Tumor necrosis factor TNF 0.0059
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0058
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0058
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0058
6220 Aryl hydrocarbon receptor AHR 0.0057
174 Sigma 1-type opioid receptor SIGMAR1 0.0057
504 Mast/stem cell growth factor receptor KIT 0.0057
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0057
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0056
6506 Stathmin-4 STMN4 0.0055
373 Transthyretin TTR 0.0054
4604 Liver carboxylesterase 1 CES1 0.0054
891 Dihydropteroate synthase folP 0.0054
5359 Dihydropteroate synthase folP 0.0054
7175 Dihydropteroate synthase sulI 0.0054
407 Vascular endothelial growth factor receptor 2 KDR 0.0052
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0052
2981 Phospholipase A2, membrane associated PLA2G2A 0.0052
1256 5-hydroxytryptamine 6 receptor HTR6 0.0052
49 Endothelin B receptor EDNRB 0.0052
70 Type-1 angiotensin II receptor AGTR1 0.0052
1618 High affinity nerve growth factor receptor NTRK1 0.0052
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0052
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0052
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0052
4120 NADPH--cytochrome P450 reductase POR 0.0051
2112 Toll-like receptor 9 TLR9 0.0051
319 Opioid receptor, sigma 1 OPRS1 0.0051
6014 Cytochrome P450 2A13 CYP2A13 0.005
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.005
1024 Solute carrier family 22 member 11 SLC22A11 0.005
26 Vascular endothelial growth factor receptor 3 FLT4 0.0049
6137 Multidrug resistance-associated protein 6 ABCC6 0.0049
578 Endothelin-1 receptor EDNRA 0.0049
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0049
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0049
173 Toll-like receptor 7 TLR7 0.0049
68 Cannabinoid receptor 1 CNR1 0.0048
1360 Sphingomyelin phosphodiesterase SMPD1 0.0047
32 Vascular endothelial growth factor receptor 1 FLT1 0.0047
856 Vitamin D3 receptor VDR 0.0047
811 Translocator protein TSPO 0.0047
828 Phenylalanine-4-hydroxylase PAH 0.0047
3109 Phenylalanine-4-hydroxylase phhA 0.0047
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0047
6102 Arylamine N-acetyltransferase 2 NAT2 0.0047
756 Sex hormone-binding globulin SHBG 0.0046
295 Carbonic anhydrase 1 CA1 0.0046
565 Extracellular calcium-sensing receptor CASR 0.0046
357 Carbonic anhydrase 2 CA2 0.0046
528 5-hydroxytryptamine 1E receptor HTR1E 0.0046
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0045
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0045
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0044
571 Melatonin receptor type 1A MTNR1A 0.0044
362 Melatonin receptor type 1B MTNR1B 0.0044
1010 Cytochrome P450 51A1 CYP51A1 0.0044
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0044
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0043
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0043
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0043
2539 Tubulin alpha-1 chain TUBA4A 0.0043
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0042
6136 Multidrug resistance-associated protein 5 ABCC5 0.0041
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0041
228 Beta platelet-derived growth factor receptor PDGFRB 0.0041
3947 Xanthine dehydrogenase/oxidase XDH 0.0041
365 Dihydrofolate reductase DHFR 0.0041
2381 Dihydrofolate reductase DFR1 0.0041
2833 Dihydrofolate reductase Not Available 0.0041
2931 Dihydrofolate reductase folA 0.0041
3544 Dihydrofolate reductase folA 0.0041
3682 Dihydrofolate reductase folA 0.0041
6642 Dihydrofolate reductase folA 0.0041
6756 Dihydrofolate reductase dfrA 0.0041
3997 Cytochrome P450 24A1, mitochondrial CYP24A1 0.0041
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.004
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.004
29 Tubulin beta-1 chain TUBB1 0.004
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0039
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.0039
814 Ryanodine receptor 1 RYR1 0.0039
1129 C-C chemokine receptor type 5 CCR5 0.0039
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0039
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0038
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0038
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0038
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0038
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0038
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0038
85 Growth hormone receptor GHR 0.0038
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0037
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0037
6141 Sodium/bile acid cotransporter SLC10A1 0.0037
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0037
183 Vascular endothelial growth factor A VEGFA 0.0037
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0036
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0036
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0036
6020 Aldehyde oxidase AOX1 0.0036
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0036
633 Penicillin-binding proteins 1A/1B pbpA 0.0036
4237 50S ribosomal protein L22 rplV 0.0035
185 Vasopressin V1a receptor AVPR1A 0.0035
921 Glutamate receptor 2 GRIA2 0.0035
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0035
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0035
939 50S ribosomal protein L3 rplC 0.0035
322 Vasopressin V2 receptor AVPR2 0.0034
6043 Putative G-protein coupled receptor 44 GPR44 0.0034
6126 Carbonic anhydrase 7 CA7 0.0034
596 3-oxo-5-alpha-steroid 4-dehydrogenase 1 SRD5A1 0.0033
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0033
284 DNA-directed RNA polymerase beta chain rpoB 0.0033
5773 DNA-directed RNA polymerase beta chain rpoB 0.0033
737 Mineralocorticoid receptor NR3C2 0.0033
1483 Membrane copper amine oxidase AOC3 0.0033
427 Substance-P receptor TACR1 0.0033
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0032
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0032
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0032
581 Cytochrome P450 2R1 CYP2R1 0.0032
140 30S ribosomal protein S9 rpsI 0.0031
6719 30S ribosomal protein S9 rpsI 0.0031
6725 30S ribosomal protein S9 rpsI 0.0031
1050 Bile salt sulfotransferase SULT2A1 0.0031
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0031
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0031
869 Estrogen receptor beta ESR2 0.0031
1629 Transcription factor AP-1 JUN 0.0031
5300 Antigen peptide transporter 1 TAP1 0.0031
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0031
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0031
2578 Tubulin beta-3 chain TUBB3 0.003
4311 tRNA TRDMT1 0.003
4325 tRNA trmD 0.003
4328 tRNA trmD 0.003
2285 Streptogramin A acetyltransferase vatD 0.003
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.003
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.003
705 Glutamate receptor 1 GRIA1 0.003
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.003
4203 Histamine N-methyltransferase HNMT 0.003
518 Peroxidase/catalase T katG 0.003
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0029
1178 Adenosine A2a receptor ADORA2A 0.0029
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0029
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0028
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0028
4122 Histone deacetylase 2 HDAC2 0.0028
3932 Glutathione S-transferase A2 GSTA2 0.0028
723 Cytosolic phospholipase A2 PLA2G4A 0.0027
563 Thyroid peroxidase TPO 0.0027
2449 Tubulin alpha-3 chain TUBA1A 0.0027
738 Monocarboxylate transporter 1 SLC16A1 0.0027
4173 Tyrosine-protein kinase JAK2 JAK2 0.0027
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0027
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0027
4228 Keratin, type II cytoskeletal 7 KRT7 0.0027
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0026
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0026
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0026
634 Squalene monooxygenase SQLE 0.0026
7196 Squalene monooxygenase ERG1 0.0026
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0025
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0025
823 Fibroblast growth factor receptor 2 FGFR2 0.0025
768 FK506-binding protein 1A FKBP1A 0.0025
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0025
544 Potassium voltage-gated channel subfamily E member 1 KCNE1 0.0024
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0024
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0024
2300 Lysozyme E 0.0024
3633 Lysozyme R 0.0024
5597 Lysozyme 17 0.0024
6039 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A PDE11A 0.0024
233 Potassium channel subfamily K member 2 KCNK2 0.0024
5852 Type-2 angiotensin II receptor AGTR2 0.0024
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0024
642 3-oxo-5-alpha-steroid 4-dehydrogenase 2 SRD5A2 0.0023
3086 Plasmepsin-2 Not Available 0.0023
65 Matrix metalloproteinase-9 Not Available 0.0023
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0023
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0023
543 Penicillin-binding protein 1B mrcB 0.0023
6186 Penicillin-binding protein 1B ponB 0.0023
6822 Penicillin-binding protein 1b pbp1b 0.0023
6844 Penicillin-binding protein 1b pbp1b 0.0023
6151 Monocarboxylate transporter 10 SLC16A10 0.0023
208 DNA-directed RNA polymerase beta' chain rpoC 0.0022
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0022
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0022
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0022
159 Penicillin-binding protein 2B penA 0.0022
6121 Penicillin-binding protein 2B penA 0.0022
165 FL cytokine receptor FLT3 0.0022
3404 Exotoxin A eta 0.0022
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0022
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0022
298 Renin REN 0.0021
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0021
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0021
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0021
16 Adenosine A1 receptor ADORA1 0.0021
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0021
63 Malate dehydrogenase mdh 0.0021
2329 Malate dehydrogenase mdh 0.0021
3445 Malate dehydrogenase mdh 0.0021
4420 Malate dehydrogenase mdh 0.0021
4438 Malate dehydrogenase mdh 0.0021
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0021
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0021
164 Histamine H4 receptor HRH4 0.0021
3090 Chitosanase csn 0.002
4149 Nuclear factor NF-kappa-B p100 subunit NFKB2 0.002
1992 Vitamin D-binding protein GC 0.002
5787 Angiopoietin-1 receptor TEK 0.002
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.002
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.002
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.002
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.002
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.002
106 Cannabinoid receptor 2 CNR2 0.002
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.002
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0019
3856 Fibroblast growth factor receptor 3 FGFR3 0.0019
6174 50S ribosomal protein L32 rpmF 0.0019
2499 Tubulin beta-2C chain TUBB2C 0.0019
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0019
239 Coagulation factor X F10 0.0019
153 Dopamine beta-hydroxylase DBH 0.0019
1196 Complement decay-accelerating factor CD55 0.0019
976 Platelet glycoprotein IX GP9 0.0019
473 L-lactate dehydrogenase A chain LDHA 0.0019
1630 Integrin beta-2 ITGB2 0.0019
4103 Proteasome subunit beta type 2 PSMB2 0.0019
4102 Proteasome subunit beta type 5 PSMB5 0.0019
4101 Proteasome subunit beta type 1 PSMB1 0.0019
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0019
3426 Glutamine synthetase glnA 0.0019
3987 Glutamine synthetase GLUL 0.0019
477 DNA topoisomerase 4 subunit A parC 0.0019
886 DNA topoisomerase 4 subunit A parC 0.0019
6226 DNA topoisomerase 4 subunit A parC 0.0019
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0019
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0018
558 Solute carrier family 12 member 1 SLC12A1 0.0018
404 DNA gyrase subunit A gyrA 0.0018
6224 DNA gyrase subunit A gyrA 0.0018
893 [Citrate [pro-3S]-lyase] ligase citC 0.0018
845 Pyruvate dehydrogenase [cytochrome] poxB 0.0018
1253 Interferon gamma IFNG 0.0018
1192 Sulfotransferase 1A1 SULT1A1 0.0018
275 Arachidonate 5-lipoxygenase ALOX5 0.0018
5998 Toll-like receptor 8 TLR8 0.0018
4238 50S ribosomal protein L4 rplD 0.0018
5578 50S ribosomal protein L4 rplD 0.0018
6173 50S ribosomal protein L4 rplD 0.0018
6219 50S ribosomal protein L4 rplD 0.0018
712 Tubulin alpha chain TUB1 0.0018
1968 ATP-sensitive inward rectifier potassium channel 12 KCNJ12 0.0018
327 Glutathione reductase gor 0.0018
5110 Glutathione reductase GR2 0.0018
683 Potassium transporter GK0582 0.0018
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.0018
511 5-hydroxytryptamine 1F receptor HTR1F 0.0018
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.0017
537 ATP synthase delta chain, mitochondrial ATP5D 0.0017
613 Atrial natriuretic peptide receptor A NPR1 0.0017
6146 High affinity copper uptake protein 1 SLC31A1 0.0017
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.0017
2290 ADP-ribosyl cyclase 2 BST1 0.0017
7 Nitric oxide synthase, inducible NOS2 0.0017
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0017
2808 Chloramphenicol acetyltransferase 3 cat3 0.0016
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0016
144 Hemoglobin subunit alpha HBA1 0.0016
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0016
4773 Deoxycytidine kinase DCK 0.0016
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0016
1852 Microtubule-associated protein 2 MAP2 0.0016
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0016
3233 Bile acid receptor NR1H4 0.0015
3937 Fatty-acid amide hydrolase FAAH 0.0015
6044 Serum paraoxonase/lactonase 3 PON3 0.0015
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0015
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0015
6138 Multidrug resistance protein 3 ABCB4 0.0015
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0015
982 Cocaine- and amphetamine-regulated transcript protein CARTPT 0.0015
3601 Dihydropteroate synthase 1 folP1 0.0015
3807 Dihydropteroate synthase 1 folP1 0.0015
3808 Dihydropteroate synthase 2 folP2 0.0015
2417 Chloramphenicol acetyltransferase cat 0.0015
3278 Chloramphenicol acetyltransferase cat 0.0015
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0015
2810 Dr hemagglutinin structural subunit draA 0.0015
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0015
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0015
469 Annexin A1 ANXA1 0.0015
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0015
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0015
6824 Tyrosine-protein kinase Lyn LYN 0.0014
1541 Metalloproteinase mmp20 0.0014
572 Integrin alpha-L ITGAL 0.0014
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0014
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0014
3913 Glutamic acid decarboxylase GAD65 0.0014
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0014
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.0014
1864 RET proto-oncogene RET 0.0014
6085 Fatty acid-binding protein, intestinal FABP2 0.0014
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0014
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0014
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0014
1341 Histamine H3 receptor HRH3 0.0014
1262 Corticotropin-lipotropin POMC 0.0014
84 Nuclear receptor 0B1 NR0B1 0.0014
1353 DNA topoisomerase 1 TOP1 0.0013
3552 DNA topoisomerase 1 topA 0.0013
3810 Catechol O-methyltransferase COMT 0.0013
244 Angiotensin-converting enzyme ACE 0.0013
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0013
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0013
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0013
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0013
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0013
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0013
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0013
6211 Tubulin epsilon chain TUBE1 0.0013
6212 Tubulin gamma-1 chain TUBG1 0.0013
6210 Tubulin delta chain TUBD1 0.0013
6131 Carbonic anhydrase 14 CA14 0.0013
860 Nicotinamide N-methyltransferase NNMT 0.0013
699 Nicotinic acid receptor 1 GPR109A 0.0013
928 Nicotinic acid receptor 2 GPR109B 0.0013
583 Nicotinate-nucleotide pyrophosphorylase [carboxylating] QPRT 0.0013
2442 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
2459 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
5934 Cytochrome P450 26A1 CYP26A1 0.0013
6116 Gastric triacylglycerol lipase LIPF 0.0012
780 Retinoic acid receptor RXR-gamma RXRG 0.0012
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0012
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0012
3823 Cytokine receptor common gamma chain IL2RG 0.0012
2107 Microtubule-associated protein 1A MAP1A 0.0012
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0012
338 DNA polymerase UL30 0.0012
379 DNA polymerase UL54 0.0012
697 DNA polymerase ORF28 0.0012
2482 DNA polymerase 43 0.0012
4104 DNA polymerase BALF5 0.0012
4217 Telomerase reverse transcriptase TERT 0.0012
6122 Carbonic anhydrase 3 CA3 0.0012
1295 Fatty acid synthase FASN 0.0012
735 Alanine aminotransferase 1 GPT 0.0012
3904 Alanine aminotransferase 2 GPT2 0.0012
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0011
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0011
88 Retinoic acid receptor RXR-beta RXRB 0.0011
251 Alcohol dehydrogenase 1A ADH1A 0.0011
754 Pancreatic triacylglycerol lipase PNLIP 0.0011
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0011
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0011
707 72 kDa type IV collagenase MMP2 0.0011
273 Apoptosis regulator Bcl-2 BCL2 0.0011
2178 Metabotropic glutamate receptor 5 GRM5 0.0011
936 Ephrin type-A receptor 2 EPHA2 0.0011
724 Interleukin-2 receptor alpha chain IL2RA 0.0011
717 Interleukin-2 receptor subunit beta IL2RB 0.0011
3809 Estrogen-related receptor gamma ESRRG 0.0011
820 Glycine receptor subunit alpha-2 GLRA2 0.0011
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.001
54 Prothrombin F2 0.001
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.001
1810 Protein S100-A1 S100A1 0.001
6097 Protein S100-A2 S100A2 0.001
4116 Dihydropteroate synthetase Not Available 0.001
1374 Natriuretic peptides B NPPB 0.001
1827 Gap junction alpha-1 protein GJA1 0.001
1908 Vascular cell adhesion protein 1 VCAM1 0.001
1144 Hepatocyte growth factor receptor MET 0.001
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.001
493 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial CYP27B1 0.001
291 Nitric-oxide synthase, endothelial NOS3 0.001
2450 Tyrosine-protein kinase ITK/TSK ITK 0.001
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.001
2216 Fibroblast growth factor receptor 4 FGFR4 0.001
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.001
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.001
33 Cystine/glutamate transporter SLC7A11 0.001
444 Alcohol dehydrogenase 1B ADH1B 0.001
512 DNA-directed RNA polymerase alpha chain rpoA 0.001
5772 DNA-directed RNA polymerase alpha chain rpoA 0.001
4041 Microsomal glutathione S-transferase 2 MGST2 0.001
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.001
605 Fumarate reductase flavoprotein subunit frdA 0.001
2709 Fumarate reductase flavoprotein subunit SO_0970 0.001
3673 Fumarate reductase flavoprotein subunit fccA 0.001
4912 Fumarate reductase flavoprotein subunit ifcA 0.001
6549 Fumarate reductase flavoprotein subunit frdA 0.001
2268 Cholesterol oxidase choB 0.0009
2822 Cholesterol oxidase choA 0.0009
5798 Mitogen-activated protein kinase 11 MAPK11 0.0009
2320 Thymidine kinase, cytosolic TK1 0.0009
267 Plasminogen activator inhibitor 1 SERPINE1 0.0009
3830 Calreticulin CALR 0.0009
1064 DNA (cytosine-5)-methyltransferase 1 DNMT1 0.0009
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0009
6105 3-oxo-5-beta-steroid 4-dehydrogenase AKR1D1 0.0009
459 Retinoic acid receptor RXR-alpha RXRA 0.0009
6149 Solute carrier family 22 member 10 SLC22A10 0.0009
1048 Protein S100-A13 S100A13 0.0009
2226 Protein S100-A12 S100A12 0.0009
6048 Troponin C, skeletal muscle TNNC2 0.0009
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0009
1770 Phospholipase C PLCL1 0.0009
2841 Phospholipase C plc 0.0009
1648 Elastin ELN 0.0009
2283 Steroid Delta-isomerase ksi 0.0009
2920 Steroid Delta-isomerase ksi 0.0009
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0009
268 Adenosine A2b receptor ADORA2B 0.0009
390 Adenosine A3 receptor ADORA3 0.0009
6034 Hydroxyindole O-methyltransferase ASMT 0.0009
6035 Nuclear receptor ROR-beta RORB 0.0009
6036 Eosinophil peroxidase EPX 0.0009
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0009
2132 Protein S100-B S100B 0.0009
517 Alcohol dehydrogenase 1C ADH1C 0.0009
6218 Pannexin-1 PANX1 0.0008
6221 Steroid hormone receptor ERR1 ESRRA 0.0008
22 30S ribosomal protein S4 rpsD 0.0008
6714 30S ribosomal protein S4 rpsD 0.0008
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0008
2325 Sulfotransferase family cytosolic 2B member 1 SULT2B1 0.0008
1039 Histone deacetylase 9 HDAC9 0.0008
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0008
1867 Major prion protein PRNP 0.0008
2232 Interleukin-5 IL5 0.0008
1593 Mucin-2 MUC2 0.0008
4031 Glutathione S-transferase A1 GSTA1 0.0008
500 Monocarboxylate transporter 4 SLC16A3 0.0008
1649 Small inducible cytokine A2 CCL2 0.0008
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0008
1025 Aquaporin-1 AQP1 0.0008
2091 Endoplasmin HSP90B1 0.0008
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.0007
765 Indoleamine 2,3-dioxygenase IDO1 0.0007
896 Glutathione S-transferase Mu 1 GSTM1 0.0007
866 Large neutral amino acids transporter small subunit 2 SLC7A8 0.0007
1275 Estrogen sulfotransferase SULT1E1 0.0007
461 Glycine receptor subunit alpha-3 GLRA3 0.0007
130 Prostacyclin synthase PTGIS 0.0007
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0007
6103 Arylamine N-acetyltransferase 1 NAT1 0.0007
760 Fibroblast growth factor 1 FGF1 0.0007
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0007
1268 Neuropeptide S receptor NPSR1 0.0007
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0007
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0007
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0007
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0007
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0007
6207 30S ribosomal protein S14 rpsN 0.0007
6209 30S ribosomal protein S19 rpsS 0.0007
6712 30S ribosomal protein S19 rpsS 0.0007
6726 30S ribosomal protein S19 rpsS 0.0007
6134 Sodium channel subunit beta-3 SCN3B 0.0007
6133 Sodium channel subunit beta-2 SCN2B 0.0007
6135 Sodium channel subunit beta-4 SCN4B 0.0007
6132 Sodium channel subunit beta-1 SCN1B 0.0007
6129 Carbonic anhydrase-related protein 11 CA11 0.0007
6127 Carbonic anhydrase-related protein CA8 0.0007
6128 Carbonic anhydrase-related protein 10 CA10 0.0007
645 Penicillin-binding protein 1A mrcA 0.0007
5805 Penicillin-binding protein 1A ponA 0.0007
6185 Penicillin-binding protein 1A mrcA 0.0007
6799 Penicillin-binding protein 1A pbpA 0.0007
5924 Microtubule-associated protein 4 MAP4 0.0007
5923 Microtubule-associated protein tau MAPT 0.0007
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0007
2298 Cytochrome P450-cam camC 0.0007
2021 Thrombomodulin THBD 0.0007
24 Thymidylate synthase TMP1 0.0007
359 Thymidylate synthase TYMS 0.0007
2626 Thymidylate synthase thyA 0.0007
2729 Thymidylate synthase thyA 0.0007
5352 Thymidylate synthase THYA 0.0007
751 Potassium channel subfamily K member 6 KCNK6 0.0007
226 Gonadotropin-releasing hormone receptor GNRHR 0.0007
1830 5'-nucleotidase NT5E 0.0007
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0007
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0007
125 DNA polymerase beta POLB 0.0007
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0007
1123 Eosinophil cationic protein RNASE3 0.0007
2599 Tyrosine-protein kinase HCK HCK 0.0007
6073 Potassium channel subfamily K member 9 KCNK9 0.0006
6072 Potassium channel subfamily K member 3 KCNK3 0.0006
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0006
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0006
172 Potassium channel subfamily K member 1 KCNK1 0.0006
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0006
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0006
6130 Carbonic anhydrase 13 CA13 0.0006
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0006
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0006
4192 DNA topoisomerase 2-beta TOP2B 0.0006
6167 Organic solute transporter subunit beta OSTB 0.0006
6166 Organic solute transporter subunit alpha OSTA 0.0006
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0006
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0006
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0006
3957 Adenosine deaminase ADA 0.0006
6168 Solute carrier family 22 member 16 SLC22A16 0.0006
3611 Cytidine deaminase cdd 0.0006
3707 Cytidine deaminase cdd 0.0006
4211 Cytidine deaminase CDA 0.0006
1291 cAMP response element-binding protein CREB1 0.0006
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0006
1569 G1/S-specific cyclin-D1 CCND1 0.0006
1525 Heparin-binding growth factor 2 FGF2 0.0006
4210 Toll-like receptor 4 TLR4 0.0005
1760 Aminopeptidase N ANPEP 0.0005
6843 Aminopeptidase N pepN 0.0005
117 Sterol O-acyltransferase 1 SOAT1 0.0005
489 Monocarboxylate transporter 2 SLC16A7 0.0005
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0005
3007 Carbonic anhydrase 12 CA12 0.0005
4205 Carbonic anhydrase 9 CA9 0.0005
2207 Rhodopsin RHO 0.0005
6042 Prostaglandin reductase 2 PTGR2 0.0005
1714 Mitogen-activated protein kinase 3 MAPK3 0.0005
1792 Tissue-type plasminogen activator PLAT 0.0005
2236 Casein kinase II subunit alpha CSNK2A1 0.0005
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0004
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0004
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0004
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0004
76 Nitric-oxide synthase, brain NOS1 0.0004
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0004
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0004
1063 Signal transducer and activator of transcription 5B STAT5B 0.0004
1176 Mitogen-activated protein kinase 1 MAPK1 0.0004
1313 Lactoylglutathione lyase GLO1 0.0004
594 Thyroxine-binding globulin SERPINA7 0.0004
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0004
719 Retinoic acid receptor responder protein 1 RARRES1 0.0003
770 Retinoic acid-induced protein 3 GPRC5A 0.0003
758 Thyroid hormone receptor alpha THRA 0.0003
484 Tyrosine-protein kinase ABL2 ABL2 0.0003
2240 Cell division protein kinase 2 CDK2 0.0003
199 Monocarboxylate transporter 8 SLC16A2 0.0003
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0003
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0003
569 Retinal dehydrogenase 2 ALDH1A2 0.0003
346 Thyroid hormone receptor beta-1 THRB 0.0003
611 Retinal dehydrogenase 1 ALDH1A1 0.0003
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0003
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0003
908 Glutathione S-transferase theta-1 GSTT1 0.0003
162 Retinoic acid receptor gamma-1 RARG 0.0002
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0002
4936 Cytochrome c2 iso-2 Not Available 0.0001
4916 Cyanoglobin glbN 0.0001
4994 Hemoglobin-like protein HbO glbO 0.0001
4915 Cytochrome c-550 psbV 0.0001
4959 Cytochrome c-550 psbV 0.0001
5216 Cytochrome c-550 psbV 0.0001
4925 Cytochrome c-type protein SHP shp 0.0001
4904 Cytochrome c family protein GSU1996 0.0001
4943 Cytochrome c6 petJ 0.0001
3116 Bacterioferritin bfr 0.0001
4906 Bacterioferritin bfr 0.0001
4965 Bacterioferritin bfr 0.0001
4954 Soluble cytochrome b558 Not Available 0.0001
4934 Cytochrome c-551 nirM 0.0001
5218 Cytochrome c-551 nirM 0.0001
4905 Cytochrome c2 Not Available 0.0001
4939 Cytochrome c2 cycA 0.0001
4964 Cytochrome c2 cycA 0.0001
4979 Cytochrome c2 cycA 0.0001
6673 Cytochrome c2 cycA 0.0001
4910 Cytoglobin CYGB 0.0001
4984 Neuroglobin NGB 0.0001
4981 Iron-starvation protein PigA pigA 0.0001
4909 CooA protein cooA 0.0001
4998 Hemoglobin-like protein yjbI yjbI 0.0001
4935 Cytochrome c-554 cycA1 0.0001
4947 Bacterial hemoglobin vhb 0.0001
4975 Cytochrome c-556 RPA3973 0.0001
4942 Diheme cytochrome c napB napB 0.0001
4931 Cytochrome P450 167A1 CYP167A1 0.0001
5000 HemO hemO 0.0001
4972 P450cin cinA 0.0001
4960 Putative cytochrome P450-family protein SCO7417 0.0001
4971 Nonaheme cytochrome c hmcA 0.0001
4989 Cytochrome c551 peroxidase ccp 0.0001
5222 Cytochrome c551 peroxidase ccpA 0.0001
4961 Hemophore HasA hasA 0.0001
4976 Apocytochrome f petA 0.0001
6407 Apocytochrome f petA 0.0001
4907 Cytochrome c-L moxG 0.0001
6865 Cytochrome c-L moxG 0.0001
4993 Hydroxylamine oxidoreductase hao1 0.0001
4764 Cytochrome P450 165C4 CYP165C4 0.0001
4926 Heme-based aerotactic transducer hemAT hemAT 0.0001
644 Heme oxygenase 2 HMOX2 0.0001
4982 Heme oxygenase 2 pbsA2 0.0001
4952 Catalase/peroxidase katA 0.0001
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0001
4937 Cytochrome oxidase subunit II rcoxA 0.0001
4903 Methyl-accepting chemotaxis protein Tar4 0.0001
4999 Cytochrome P450 165B3 CYP165B3 0.0001
3093 Catalase HPII katE 0.0001
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0001
4922 Cytochrome c, putative SO_4144 0.0001
4920 Peroxidase/catalase katG 0.0001
4990 PpcA ppcA 0.0001
4948 Cytochrome c-553 Not Available 0.0001
4923 Cytochrome c3 DvMF_2499 0.0001
4945 Cytochrome c3 Not Available 0.0001
4949 Cytochrome c3 DVU_3171 0.0001
4968 Cytochrome c3 cytc3 0.0001
4997 Cytochrome c3 SO_2727 0.0001
5219 Cytochrome c3 cyd 0.0001
2119 Cytochrome b5 CYB5A 0.0001
4902 Nine-heme cytochrome c Ddes_2038 0.0001
3189 High-molecular-weight cytochrome c hmcA 0.0001
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0001
3375 Acidic cytochrome c3 Not Available 0.0001
4988 Sulfite oxidase, mitochondrial SUOX 0.0001
2915 Sensor protein fixL fixL 0.0001
4944 Sensor protein fixL fixL 0.0001
4813 Heme oxygenase hmuO 0.0001
5769 Heme oxygenase Not Available 0.0001
3570 Cytochrome P450 152A1 cypC 0.0001
4385 Cytochrome c' Not Available 0.0001
4967 Cytochrome c' cycA 0.0001
5038 Cytochrome c' Not Available 0.0001
5223 Cytochrome c' cycP 0.0001
4037 Hypothetical protein GPX1 0.0001
4297 Hypothetical protein SP_1951 0.0001
4521 Hypothetical protein BC_2969 0.0001
4540 Hypothetical protein TM_1070 0.0001
4555 Hypothetical protein MT1739 0.0001
4569 Hypothetical protein mshD 0.0001
4578 Hypothetical protein PA3270 0.0001
4747 Hypothetical protein PA3967 0.0001
5177 Hypothetical protein TM_0096 0.0001
5194 Hypothetical protein PA1204 0.0001
5240 Hypothetical protein Rv2991 0.0001
5370 Hypothetical protein TM_1158 0.0001
5710 Hypothetical protein Tb927.5.1360 0.0001
4289 Cytochrome P450 TT_P0059 0.0001
6262 Cytochrome P450 staP 0.0001
4992 Cytochrome c peroxidase Not Available 0.0001
2230 Catalase CAT 0.0001
3249 Catalase katA 0.0001
3625 Catalase katA 0.0001
4539 Catalase katA 0.0001
4941 Catalase katB 0.0001
3670 Soluble cytochrome b562 precursor cybC 0.0001
3411 Cytochrome P450 121 cyp121 0.0001
3291 Cytochrome c-552 cycA 0.0001
4927 Cytochrome c-552 nrfA 0.0001
4938 Cytochrome c-552 cycA 0.0001
4953 Cytochrome c-552 nrfA 0.0001
5217 Cytochrome c-552 cycM 0.0001
2617 Nitric oxide synthase oxygenase nos 0.0001
2701 Nitric oxide synthase oxygenase nos 0.0001
3102 Flavohemoprotein hmp 0.0001
4969 Flavohemoprotein hmp 0.0001
4386 Hemoglobin-like protein HbN glbN 0.0001
3127 Nitrite reductase nirS 0.0001
3284 Nitrite reductase nirS 0.0001
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0001
2972 6-deoxyerythronolide B hydroxylase eryF 0.0001
3221 Cytochrome c4 cc4 0.0001
4608 Putative cytochrome P450 SCO1207 0.0001
4963 Putative cytochrome P450 SCO2884 0.0001
6254 Putative cytochrome P450 SCO6998 0.0001
358 Cystathionine beta-synthase CBS 0
1507 Cytochrome c CYCS 0
693 Hemoglobin subunit beta HBB 0
6268 Hydroxyacid oxidase 1 HAO1 0
810 Heme oxygenase 1 HMOX1 0
3391 Heme oxygenase 1 pbsA1 0
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