DT-Web: DB00647

Identification

Name

Propoxyphene

Accession Number

DB00647 (APRD00548)

Type

small molecule

Description

A narcotic analgesic structurally related to methadone. Only the dextro-isomer has an analgesic effect; the levo-isomer appears to exert an antitussive effect. [PubChem]

Structure

MOL SDF PDB SMILES InChI

Categories ^(*)

Molecular Weight

339.4712

Groups

illicit

Monoisotopic Weight

339.219829177

Pharmacology

Indication

For the relief of mild to moderate pain

Mechanism of action

Propoxyphene acts as a weak agonist at OP1, OP2, and OP3 opiate receptors within the central nervous system (CNS). Propoxyphene primarily affects OP3 receptors, which are coupled with G-protein receptors and function as modulators, both positive and negative, of synaptic transmission via G-proteins that activate effector proteins. Binding of the opiate stimulates the exchange of GTP for GDP on the G-protein complex. As the effector system is adenylate cyclase and cAMP located at the inner surface of the plasma membrane, opioids decrease intracellular cAMP by inhibiting adenylate cyclase. Subsequently, the release of nociceptive neurotransmitters such as substance P, GABA, dopamine, acetylcholine, and noradrenaline is inhibited. Opioids such as propoxyphene also inhibit the release of vasopressin, somatostatin, insulin, and glucagon. Opioids close N-type voltage-operated calcium channels (OP2-receptor agonist) and open calcium-dependent inwardly rectifying potassium channels (OP3 and OP1 receptor agonist). This results in hyperpolarization and reduced neuronal excitability.

Absorption

Not Available

Protein binding

Not Available

Biotransformation

Hepatic

Route of elimination

The major route of metabolism is cytochrome CYP3A4 mediated N-demethylation to norpropoxyphene, which is excreted by the kidneys. In 48 hours, approximately 20% to 25% of the administered dose of propoxyphene is excreted via the urine, most of which is free or conjugated norpropoxyphene.

Toxicity

Coma, respiratory depression, circulatory collapse, and pulmonary edema. Seizures occur more frequently in patients with propoxyphene intoxication than in those with opiate intoxication. LD₅₀=230mg/kg (orally in rat, Emerson)

Affected organisms

Humans and other mammals

Interactions

Drug Interactions

Drug	Mechanism of interaction
Acenocoumarol	Propoxyphene may increase the anticoagulant effect of acenocoumarol.
Alvimopan	Increases levels by receptor binding competition. Discontinue opioid administration at least 7 days prior to administrating Alvimopan.
Anisindione	Propoxyphene may increase the anticoagulant effect of anisindione.
Atomoxetine	The CYP2D6 inhibitor could increase the effect and toxicity of atomoxetine
Carbamazepine	Propoxyphene increases the effect of carbamazepine
Cimetidine	Cimetidine, a moderate CYP3A4 inhibitor, may decrease the metabolism of propoxyphene. Monitor for changes in the therapeutic and adverse effects of propoxyphene if cimetidine is intitiated, discontinued or dose changed.
Dicumarol	Propoxyphene may increase the anticoagulant effect of dicumarol.
Insulin Lispro	Concomitant therapy with drugs that may increase the blood-glucose-lowering effect of insulin lispro and thus the chance of hypoglycemia should be monitored closely.
Ritonavir	Ritonavir increases the levels of analgesic
Tranylcypromine	Increased risk of serotonin syndrome. Concomitant use should be avoided.
Triprolidine	The CNS depressants, Triprolidine and Propoxyphene, may increase adverse/toxic effects due to additivity. Monitor for increased CNS depressant effects during concomitant therapy.
Warfarin	Propoxyphene may increase the anticoagulant effect of warfarin.

Food Interactions

Take without regard to meals. Avoid alcohol.

Mu-type opioid receptor
Name	Mu-type opioid receptor
Gene Name	OPRM1
Pharmacological action	yes
Actions	agonist
References	Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed Ulens C, Daenens P, Tytgat J: Norpropoxyphene-induced cardiotoxicity is associated with changes in ion-selectivity and gating of HERG currents. Cardiovasc Res. 1999 Dec;44(3):568-78. - Pubmed Tyers MB: A classification of opiate receptors that mediate antinociception in animals. Br J Pharmacol. 1980 Jul;69(3):503-12. - Pubmed Picker MJ: Discriminative stimulus effects of the mixed-opioid agonist/antagonist dezocine: cross-substitution by mu and delta opioid agonists. J Pharmacol Exp Ther. 1997 Dec;283(3):1009-17. - Pubmed Codd EE, Shank RP, Schupsky JJ, Raffa RB: Serotonin and norepinephrine uptake inhibiting activity of centrally acting analgesics: structural determinants and role in antinociception. J Pharmacol Exp Ther. 1995 Sep;274(3):1263-70. - Pubmed Bannwarth B, Richez C: The dextropropoxyphene controversy. Joint Bone Spine. 2009 Oct;76(5):449-51. Epub 2009 Jul 14. - Pubmed Walker EA, Tiano MJ, Benyas SI, Dykstra LA, Picker MJ: Naltrexone and beta-funaltrexamine antagonism of the antinociceptive and response rate-decreasing effects of morphine, dezocine, and d-propoxyphene. Psychopharmacology (Berl). 1999 May;144(1):45-53. - Pubmed
DTHybrid score	0.9989
Delta-type opioid receptor
Name	Delta-type opioid receptor
Gene Name	OPRD1
Pharmacological action	yes
Actions	agonist
References	Neil A: Affinities of some common opioid analgesics towards four binding sites in mouse brain. Naunyn Schmiedebergs Arch Pharmacol. 1984 Nov;328(1):24-9. - Pubmed
DTHybrid score	0.8145
Kappa-type opioid receptor
Name	Kappa-type opioid receptor
Gene Name	OPRK1
Pharmacological action	yes
Actions	antagonist
References	Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed Neil A: Affinities of some common opioid analgesics towards four binding sites in mouse brain. Naunyn Schmiedebergs Arch Pharmacol. 1984 Nov;328(1):24-9. - Pubmed
DTHybrid score	0.7894

Cytochrome P450 3A4
Name	Cytochrome P450 3A4
Gene Name	CYP3A4
Actions	substrate,inhibitor
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.6435
Cytochrome P450 2D6
Name	Cytochrome P450 2D6
Gene Name	CYP2D6
Actions	inhibitor
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.5119
Cytochrome P450 2C8
Name	Cytochrome P450 2C8
Gene Name	CYP2C8
Actions	inhibitor
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.3345
Cytochrome P450 2C9
Name	Cytochrome P450 2C9
Gene Name	CYP2C9
Actions	inhibitor
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.4248
Cytochrome P450 3A7
Name	Cytochrome P450 3A7
Gene Name	CYP3A7
Actions	inducer
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.2856

Id	Partner name	Gene Name	Score
4118	Cytochrome P450 3A5	CYP3A5	0.2814
6016	Cytochrome P450 2C19	CYP2C19	0.2538
1588	Multidrug resistance protein 1	ABCB1	0.2405
4200	Cytochrome P450 1A2	CYP1A2	0.1996
6030	Cytochrome P450 2B6	CYP2B6	0.1571
1716	Tripartite motif-containing protein 13	TRIM13	0.115
6013	Cytochrome P450 2E1	CYP2E1	0.1141
20	Prostaglandin G/H synthase 1	PTGS1	0.0861
1262	Corticotropin-lipotropin	POMC	0.0859
587	Serum albumin	ALB	0.0835
5718	Cytochrome P450 2A6	CYP2A6	0.0808
6024	Cytochrome P450 1A1	CYP1A1	0.0765
824	Sodium-dependent serotonin transporter	SLC6A4	0.0677
1732	ATP-binding cassette sub-family G member 2	ABCG2	0.0643
492	Histamine H1 receptor	HRH1	0.0636
6106	Cytochrome P450 2C18	CYP2C18	0.061
540	Sodium-dependent noradrenaline transporter	SLC6A2	0.0597
6022	UDP-glucuronosyltransferase 1-1	UGT1A1	0.0579
6018	UDP-glucuronosyltransferase 1-9	UGT1A9	0.0576
6178	UDP-glucuronosyltransferase 2B7	UGT2B7	0.057
1181	Alpha-1-acid glycoprotein 1	ORM1	0.057
6139	Solute carrier organic anion transporter family member 1A2	SLCO1A2	0.0492
1490	Solute carrier organic anion transporter family member 1B1	SLCO1B1	0.049
1735	Canalicular multispecific organic anion transporter 1	ABCC2	0.0465
502	5-hydroxytryptamine 2A receptor	HTR2A	0.0449
6145	Solute carrier family 22 member 1	SLC22A1	0.0419
3811	Cytochrome P450 19A1	CYP19A1	0.041
862	Multidrug resistance-associated protein 1	ABCC1	0.0402
341	5-hydroxytryptamine 3 receptor	HTR3A	0.0402
831	D(2) dopamine receptor	DRD2	0.0397
4137	Nociceptin receptor	OPRL1	0.0389
174	Sigma 1-type opioid receptor	SIGMAR1	0.0388
319	Opioid receptor, sigma 1	OPRS1	0.0386
290	Prostaglandin G/H synthase 2	PTGS2	0.0381
590	5-hydroxytryptamine 2C receptor	HTR2C	0.0368
6180	UDP-glucuronosyltransferase 2B4	UGT2B4	0.0366
556	Alpha-1A adrenergic receptor	ADRA1A	0.0364
51	Muscarinic acetylcholine receptor M3	CHRM3	0.0363
1729	Solute carrier family 22 member 6	SLC22A6	0.0358
220	Sodium channel protein type 5 subunit alpha	SCN5A	0.0357
320	5-hydroxytryptamine 1A receptor	HTR1A	0.0336
103	Muscarinic acetylcholine receptor M1	CHRM1	0.0335
6176	UDP-glucuronosyltransferase 1-3	UGT1A3	0.0332
136	Estrogen receptor	ESR1	0.0331
101	Potassium voltage-gated channel subfamily H member 2	KCNH2	0.0313
1898	Cytochrome P450 1B1	CYP1B1	0.0306
766	Beta-2 adrenergic receptor	ADRB2	0.0305
318	Alpha-2A adrenergic receptor	ADRA2A	0.0303
872	Gamma-aminobutyric-acid receptor subunit alpha-1	GABRA1	0.028
871	Glucocorticoid receptor	NR3C1	0.0276
713	Sodium-dependent dopamine transporter	SLC6A3	0.0271
6031	Cytochrome P450 3A43	CYP3A43	0.027
776	Bile salt export pump	ABCB11	0.0268
465	Calmodulin	CALM1	0.0266
6144	Solute carrier family 22 member 2	SLC22A2	0.0263
731	HIV-1 protease	HIV-1 protease	0.0254
617	Muscarinic acetylcholine receptor M2	CHRM2	0.0251
706	Glutamate [NMDA] receptor subunit 3A	GRIN3A	0.0249
193	Beta-1 adrenergic receptor	ADRB1	0.0235
118	Organic cation/carnitine transporter 2	SLC22A5	0.0234
2164	Multidrug resistance-associated protein 4	ABCC4	0.0231
23	D(1A) dopamine receptor	DRD1	0.0231
632	Alpha-1B adrenergic receptor	ADRA1B	0.0219
6157	Solute carrier organic anion transporter family member 1B3	SLCO1B3	0.0217
6017	Cholesterol side-chain cleavage enzyme, mitochondrial	CYP11A1	0.0208
6143	Solute carrier family 22 member 7	SLC22A7	0.0205
274	Muscarinic acetylcholine receptor M5	CHRM5	0.0204
450	Muscarinic acetylcholine receptor M4	CHRM4	0.0199
638	D(3) dopamine receptor	DRD3	0.0198
6142	Solute carrier family 22 member 8	SLC22A8	0.0196
6181	UDP-glucuronosyltransferase 1-8	UGT1A8	0.0193
805	Cytochrome P450 11B1, mitochondrial	CYP11B1	0.0191
4115	Voltage-dependent L-type calcium channel subunit alpha-1D	CACNA1D	0.0189
260	Cytochrome P450 51	ERG11	0.0189
761	Cytochrome P450 51	ERG11	0.0189
3163	Cytochrome P450 51	cyp51	0.0189
1291	cAMP response element-binding protein	CREB1	0.0185
478	Voltage-dependent L-type calcium channel subunit alpha-1C	CACNA1C	0.0185
392	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	CACNA1A	0.0181
885	5-hydroxytryptamine 1B receptor	HTR1B	0.0181
580	Gamma-aminobutyric-acid receptor subunit alpha-3	GABRA3	0.0178
423	Gamma-aminobutyric-acid receptor subunit alpha-2	GABRA2	0.0177
4111	Voltage-dependent L-type calcium channel subunit alpha-1S	CACNA1S	0.0176
5838	Transient receptor potential cation channel subfamily V member 3	TRPV3	0.0176
2162	Transient receptor potential cation channel subfamily M member 8	TRPM8	0.0176
1944	Transient receptor potential cation channel subfamily A member 1	TRPA1	0.0176
1709	Canalicular multispecific organic anion transporter 2	ABCC3	0.0176
6182	Cytochrome P450 2J2	CYP2J2	0.0175
3941	Amine oxidase [flavin-containing] A	MAOA	0.0173
891	Dihydropteroate synthase	folP	0.0171
5359	Dihydropteroate synthase	folP	0.0171
7175	Dihydropteroate synthase	sulI	0.0171
1632	Solute carrier organic anion transporter family member 2B1	SLCO2B1	0.017
4210	Toll-like receptor 4	TLR4	0.0168
4110	Voltage-dependent L-type calcium channel subunit beta-2	CACNB2	0.0164
614	Progesterone receptor	PGR	0.0163
6147	Solute carrier family 22 member 3	SLC22A3	0.016
631	3-hydroxy-3-methylglutaryl-coenzyme A reductase	HMGCR	0.0155
3387	3-hydroxy-3-methylglutaryl-coenzyme A reductase	mvaA	0.0155
523	Gamma-aminobutyric-acid receptor subunit alpha-5	GABRA5	0.0155
4120	NADPH--cytochrome P450 reductase	POR	0.0154
833	Organic cation/carnitine transporter 1	SLC22A4	0.0151
94	5-hydroxytryptamine 4 receptor	HTR4	0.0149
789	Alpha-1D adrenergic receptor	ADRA1D	0.0147
238	Peroxisome proliferator-activated receptor gamma	PPARG	0.0145
964	Voltage-dependent T-type calcium channel subunit alpha-1H	CACNA1H	0.0143
468	Cytochrome P450 4A11	CYP4A11	0.0141
122	P2Y purinoceptor 12	P2RY12	0.0141
811	Translocator protein	TSPO	0.014
230	ATP-binding cassette transporter sub-family C member 8	ABCC8	0.014
6101	Dimethylaniline monooxygenase [N-oxide-forming] 3	FMO3	0.0139
5878	Alpha-7 nicotinic cholinergic receptor subunit	CHRFAM7A	0.0138
629	Alpha-2B adrenergic receptor	ADRA2B	0.0138
6079	Neuronal acetylcholine receptor subunit alpha-3	CHRNA3	0.0135
70	Type-1 angiotensin II receptor	AGTR1	0.0134
762	Voltage-dependent calcium channel subunit alpha-2/delta-1	CACNA2D1	0.0134
750	Voltage-dependent calcium channel gamma-1 subunit	CACNG1	0.0133
432	D(4) dopamine receptor	DRD4	0.0132
6104	Dimethylaniline monooxygenase [N-oxide-forming] 1	FMO1	0.013
3939	Amine oxidase [flavin-containing] B	MAOB	0.013
378	Alpha-2C adrenergic receptor	ADRA2C	0.0129
817	DNA topoisomerase 2-alpha	TOP2A	0.0129
380	Cytochrome P450 17A1	CYP17A1	0.0128
535	Voltage-dependent T-type calcium channel subunit alpha-1G	CACNA1G	0.0127
4099	Gamma-aminobutyric-acid receptor subunit beta-3	GABRB3	0.0127
146	Androgen receptor	AR	0.0125
1024	Solute carrier family 22 member 11	SLC22A11	0.0125
6148	Multidrug resistance-associated protein 7	ABCC10	0.0124
737	Mineralocorticoid receptor	NR3C2	0.0123
4148	Serine/threonine-protein kinase mTOR	MTOR	0.0122
725	5-hydroxytryptamine 1D receptor	HTR1D	0.0121
504	Mast/stem cell growth factor receptor	KIT	0.012
6078	Neuronal acetylcholine receptor subunit beta-4	CHRNB4	0.012
80	Peroxisome proliferator-activated receptor alpha	PPARA	0.0116
385	Potassium-transporting ATPase alpha chain 1	ATP4A	0.0115
198	Sodium channel protein type 10 subunit alpha	SCN10A	0.0112
787	Vitamin K epoxide reductase complex subunit 1	VKORC1	0.0111
232	Corticosteroid-binding globulin	SERPINA6	0.0109
15	Voltage-dependent T-type calcium channel subunit alpha-1I	CACNA1I	0.0107
6102	Arylamine N-acetyltransferase 2	NAT2	0.0107
3923	Cholinesterase	BCHE	0.0106
436	5-hydroxytryptamine 2B receptor	HTR2B	0.0105
458	Neuronal acetylcholine receptor subunit alpha-10	CHRNA10	0.0104
530	Gamma-aminobutyric-acid receptor subunit alpha-4	GABRA4	0.0103
841	Gamma-aminobutyric-acid receptor subunit alpha-6	GABRA6	0.0102
6023	Cytochrome P450 11B2, mitochondrial	CYP11B2	0.0102
6136	Multidrug resistance-associated protein 5	ABCC5	0.0101
1284	Nuclear receptor subfamily 1 group I member 2	NR1I2	0.0101
4100	Gamma-aminobutyric-acid receptor subunit beta-2	GABRB2	0.01
204	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE5A	0.01
756	Sex hormone-binding globulin	SHBG	0.01
29	Tubulin beta-1 chain	TUBB1	0.01
6141	Sodium/bile acid cotransporter	SLC10A1	0.0099
474	Acetylcholinesterase	ACHE	0.0098
620	Bifunctional dihydrofolate reductase-thymidylate synthase	Not Available	0.0098
4116	Dihydropteroate synthetase	Not Available	0.0097
1539	Oligopeptide transporter, small intestine isoform	SLC15A1	0.0097
844	Epidermal growth factor receptor	EGFR	0.0097
365	Dihydrofolate reductase	DHFR	0.0097
2381	Dihydrofolate reductase	DFR1	0.0097
2833	Dihydrofolate reductase	Not Available	0.0097
2931	Dihydrofolate reductase	folA	0.0097
3544	Dihydrofolate reductase	folA	0.0097
3682	Dihydrofolate reductase	folA	0.0097
6642	Dihydrofolate reductase	folA	0.0097
6756	Dihydrofolate reductase	dfrA	0.0097
6086	Gamma-aminobutyric acid receptor subunit gamma-2	GABRG2	0.0094
4604	Liver carboxylesterase 1	CES1	0.0094
716	5-hydroxytryptamine 7 receptor	HTR7	0.0093
952	Dipeptidyl peptidase 4	DPP4	0.0093
407	Vascular endothelial growth factor receptor 2	KDR	0.0093
4160	Voltage-dependent calcium channel subunit alpha-2/delta-2	CACNA2D2	0.0092
161	Tubulin beta chain	TUBB	0.0089
312	Tubulin beta chain	TUB2	0.0089
621	Periplasmic [Fe] hydrogenase 1	Not Available	0.0088
6087	Gamma-aminobutyric acid receptor subunit gamma-1	GABRG1	0.0088
6093	Gamma-aminobutyric acid receptor subunit delta	GABRD	0.0088
6089	Gamma-aminobutyric acid receptor subunit epsilon	GABRE	0.0088
1010	Cytochrome P450 51A1	CYP51A1	0.0087
163	D(1B) dopamine receptor	DRD5	0.0087
208	DNA-directed RNA polymerase beta' chain	rpoC	0.0087
5774	DNA-directed RNA polymerase beta' chain	rpoC	0.0087
4098	Gamma-aminobutyric-acid receptor subunit beta-1	GABRB1	0.0085
6088	Gamma-aminobutyric acid receptor subunit gamma-3	GABRG3	0.0084
6090	Gamma-aminobutyric acid receptor subunit pi	GABRP	0.0084
6115	Gamma-aminobutyric acid receptor subunit rho-3	GABRR3	0.0084
6092	Gamma-aminobutyric acid receptor subunit rho-2	GABRR2	0.0084
464	Glutamate [NMDA] receptor subunit epsilon-2	GRIN2B	0.0084
427	Substance-P receptor	TACR1	0.0084
142	Gamma-aminobutyric-acid receptor subunit rho-1	GABRR1	0.0083
295	Carbonic anhydrase 1	CA1	0.0083
778	Cysteinyl leukotriene receptor 1	CYSLTR1	0.0083
228	Beta platelet-derived growth factor receptor	PDGFRB	0.0083
1050	Bile salt sulfotransferase	SULT2A1	0.0082
6177	UDP-glucuronosyltransferase 1-10	UGT1A10	0.0081
818	50S ribosomal protein L10	rplJ	0.0079
869	Estrogen receptor beta	ESR2	0.0079
1995	Sodium channel protein type 9 subunit alpha	SCN9A	0.0079
4177	Proto-oncogene tyrosine-protein kinase receptor ret	RET	0.0079
462	Intermediate conductance calcium-activated potassium channel protein 4	KCNN4	0.0078
1618	High affinity nerve growth factor receptor	NTRK1	0.0077
6091	Gamma-aminobutyric acid receptor subunit theta	GABRQ	0.0076
1256	5-hydroxytryptamine 6 receptor	HTR6	0.0076
26	Vascular endothelial growth factor receptor 3	FLT4	0.0076
6025	UDP-glucuronosyltransferase 1-4	UGT1A4	0.0075
950	Alpha platelet-derived growth factor receptor	PDGFRA	0.0075
3804	Sodium channel protein type 4 subunit alpha	SCN4A	0.0075
858	Potassium voltage-gated channel subfamily A member 1	KCNA1	0.0075
1541	Metalloproteinase	mmp20	0.0074
6137	Multidrug resistance-associated protein 6	ABCC6	0.0074
592	Carbonic anhydrase 4	CA4	0.0073
32	Vascular endothelial growth factor receptor 1	FLT1	0.0072
2183	Fatty acid-binding protein, adipocyte	FABP4	0.0072
6220	Aryl hydrocarbon receptor	AHR	0.0071
6020	Aldehyde oxidase	AOX1	0.0071
4203	Histamine N-methyltransferase	HNMT	0.0071
17	Proto-oncogene tyrosine-protein kinase ABL1	ABL1	0.007
6158	Solute carrier organic anion transporter family member 1C1	SLCO1C1	0.007
485	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	PDE3A	0.007
4113	Voltage-dependent L-type calcium channel subunit alpha-1F	CACNA1F	0.0069
49	Endothelin B receptor	EDNRB	0.0069
124	Histamine H2 receptor	HRH2	0.0069
2112	Toll-like receptor 9	TLR9	0.0068
1656	CYP2B protein	CYP2B	0.0068
650	Aldo-keto reductase family 1 member C3	AKR1C3	0.0067
814	Ryanodine receptor 1	RYR1	0.0067
1757	Myeloperoxidase	MPO	0.0065
596	3-oxo-5-alpha-steroid 4-dehydrogenase 1	SRD5A1	0.0065
578	Endothelin-1 receptor	EDNRA	0.0065
777	Tumor necrosis factor	TNF	0.0065
6085	Fatty acid-binding protein, intestinal	FABP2	0.0065
837	Glutamate [NMDA] receptor subunit epsilon-1	GRIN2A	0.0065
606	Cytochrome P450 27, mitochondrial	CYP27A1	0.0065
88	Retinoic acid receptor RXR-beta	RXRB	0.0065
698	B-Raf proto-oncogene serine/threonine-protein kinase	BRAF	0.0065
6014	Cytochrome P450 2A13	CYP2A13	0.0064
4095	Neuronal acetylcholine receptor subunit alpha-7	CHRNA7	0.0064
947	Neuronal acetylcholine receptor subunit alpha-4	CHRNA4	0.0064
2222	Equilibrative nucleoside transporter 1	SLC29A1	0.0063
738	Monocarboxylate transporter 1	SLC16A1	0.0063
1178	Adenosine A2a receptor	ADORA2A	0.0063
133	Dihydropterate synthase	sulI	0.0063
3810	Catechol O-methyltransferase	COMT	0.0062
439	Glutamate [NMDA] receptor subunit epsilon-4	GRIN2D	0.0062
990	Dual specificity mitogen-activated protein kinase kinase 1	MAP2K1	0.0062
6098	Potassium voltage-gated channel subfamily D member 2	KCND2	0.0061
6099	Potassium voltage-gated channel subfamily D member 3	KCND3	0.0061
373	Transthyretin	TTR	0.006
147	Aldehyde dehydrogenase, mitochondrial	ALDH2	0.006
781	ATP-sensitive inward rectifier potassium channel 11	KCNJ11	0.006
528	5-hydroxytryptamine 1E receptor	HTR1E	0.006
158	Sodium channel protein type 1 subunit alpha	SCN1A	0.0059
131	Synaptic vesicular amine transporter	SLC18A2	0.0059
6100	BDNF/NT-3 growth factors receptor	NTRK2	0.0058
275	Arachidonate 5-lipoxygenase	ALOX5	0.0058
1974	Oligopeptide transporter, kidney isoform	SLC15A2	0.0058
6045	Voltage-dependent calcium channel subunit alpha-2/delta-3	CACNA2D3	0.0058
768	FK506-binding protein 1A	FKBP1A	0.0057
40	RAF proto-oncogene serine/threonine-protein kinase	RAF1	0.0056
813	Neuronal acetylcholine receptor subunit alpha-2	CHRNA2	0.0056
1629	Transcription factor AP-1	JUN	0.0056
24	Thymidylate synthase	TMP1	0.0055
359	Thymidylate synthase	TYMS	0.0055
2626	Thymidylate synthase	thyA	0.0055
2729	Thymidylate synthase	thyA	0.0055
5352	Thymidylate synthase	THYA	0.0055
642	3-oxo-5-alpha-steroid 4-dehydrogenase 2	SRD5A2	0.0055
16	Adenosine A1 receptor	ADORA1	0.0055
4122	Histone deacetylase 2	HDAC2	0.0055
505	Glutamate [NMDA] receptor subunit epsilon-3	GRIN2C	0.0055
6506	Stathmin-4	STMN4	0.0055
357	Carbonic anhydrase 2	CA2	0.0055
401	Glutamate [NMDA] receptor subunit zeta-1	GRIN1	0.0054
1086	Potassium voltage-gated channel subfamily KQT member 2	KCNQ2	0.0054
4237	50S ribosomal protein L22	rplV	0.0054
165	FL cytokine receptor	FLT3	0.0054
856	Vitamin D3 receptor	VDR	0.0054
6154	Multidrug and toxin extrusion protein 1	SLC47A1	0.0053
469	Annexin A1	ANXA1	0.0053
6047	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	PDE1A	0.0053
1196	Complement decay-accelerating factor	CD55	0.0051
66	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II	HSD3B2	0.0051
4199	Sphingosine 1-phosphate receptor Edg-8	S1PR5	0.005
5692	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	PDE1B	0.005
477	DNA topoisomerase 4 subunit A	parC	0.005
886	DNA topoisomerase 4 subunit A	parC	0.005
6226	DNA topoisomerase 4 subunit A	parC	0.005
1275	Estrogen sulfotransferase	SULT1E1	0.005
404	DNA gyrase subunit A	gyrA	0.0049
6224	DNA gyrase subunit A	gyrA	0.0049
1457	Long-chain-fatty-acid--CoA ligase 4	ACSL4	0.0049
1852	Microtubule-associated protein 2	MAP2	0.0049
84	Nuclear receptor 0B1	NR0B1	0.0049
173	Toll-like receptor 7	TLR7	0.0049
2539	Tubulin alpha-1 chain	TUBA4A	0.0048
1483	Membrane copper amine oxidase	AOC3	0.0048
780	Retinoic acid receptor RXR-gamma	RXRG	0.0048
5251	Carbonyl reductase [NADPH] 1	CBR1	0.0048
918	Glutamate receptor, ionotropic kainate 2	GRIK2	0.0048
567	Receptor tyrosine-protein kinase erbB-2	ERBB2	0.0047
3947	Xanthine dehydrogenase/oxidase	XDH	0.0047
723	Cytosolic phospholipase A2	PLA2G4A	0.0047
273	Apoptosis regulator Bcl-2	BCL2	0.0047
565	Extracellular calcium-sensing receptor	CASR	0.0046
6038	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6H	0.0046
1648	Elastin	ELN	0.0046
6126	Carbonic anhydrase 7	CA7	0.0046
68	Cannabinoid receptor 1	CNR1	0.0046
527	Prostacyclin receptor	PTGIR	0.0045
3086	Plasmepsin-2	Not Available	0.0045
2808	Chloramphenicol acetyltransferase 3	cat3	0.0045
518	Peroxidase/catalase T	katG	0.0045
3854	Basic fibroblast growth factor receptor 1	FGFR1	0.0044
284	DNA-directed RNA polymerase beta chain	rpoB	0.0044
5773	DNA-directed RNA polymerase beta chain	rpoB	0.0044
215	Sodium channel protein type 11 subunit alpha	SCN11A	0.0044
482	Glycine receptor subunit alpha-1	GLRA1	0.0044
130	Prostacyclin synthase	PTGIS	0.0044
921	Glutamate receptor 2	GRIA2	0.0044
6037	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6G	0.0043
709	ATP-sensitive inward rectifier potassium channel 1	KCNJ1	0.0043
1502	Peroxisome proliferator-activated receptor delta	PPARD	0.0043
1192	Sulfotransferase 1A1	SULT1A1	0.0042
5923	Microtubule-associated protein tau	MAPT	0.0042
5924	Microtubule-associated protein 4	MAP4	0.0042
4112	Voltage-dependent L-type calcium channel subunit beta-4	CACNB4	0.0041
4114	Voltage-dependent L-type calcium channel subunit beta-3	CACNB3	0.0041
6068	Guanylate cyclase soluble subunit alpha-2	GUCY1A2	0.0041
3808	Dihydropteroate synthase 2	folP2	0.0041
3601	Dihydropteroate synthase 1	folP1	0.0041
3807	Dihydropteroate synthase 1	folP1	0.0041
2417	Chloramphenicol acetyltransferase	cat	0.0041
3278	Chloramphenicol acetyltransferase	cat	0.0041
581	Cytochrome P450 2R1	CYP2R1	0.0041
1630	Integrin beta-2	ITGB2	0.0041
976	Platelet glycoprotein IX	GP9	0.0041
3997	Cytochrome P450 24A1, mitochondrial	CYP24A1	0.0041
3932	Glutathione S-transferase A2	GSTA2	0.004
2810	Dr hemagglutinin structural subunit	draA	0.004
2718	Chloramphenicol 3-O phosphotransferase	Not Available	0.004
541	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	PDE4B	0.004
162	Retinoic acid receptor gamma-1	RARG	0.004
2268	Cholesterol oxidase	choB	0.0039
2822	Cholesterol oxidase	choA	0.0039
6138	Multidrug resistance protein 3	ABCB4	0.0039
6105	3-oxo-5-beta-steroid 4-dehydrogenase	AKR1D1	0.0039
360	Ribonucleoside-diphosphate reductase large subunit	RRM1	0.0039
3970	Voltage-dependent N-type calcium channel subunit alpha-1B	CACNA1B	0.0039
1129	C-C chemokine receptor type 5	CCR5	0.0039
4773	Deoxycytidine kinase	DCK	0.0038
4209	ATP-sensitive inward rectifier potassium channel 8	KCNJ8	0.0038
571	Melatonin receptor type 1A	MTNR1A	0.0038
362	Melatonin receptor type 1B	MTNR1B	0.0038
4238	50S ribosomal protein L4	rplD	0.0038
5578	50S ribosomal protein L4	rplD	0.0038
6173	50S ribosomal protein L4	rplD	0.0038
6219	50S ribosomal protein L4	rplD	0.0038
3809	Estrogen-related receptor gamma	ESRRG	0.0038
183	Vascular endothelial growth factor A	VEGFA	0.0038
333	Voltage-dependent L-type calcium channel subunit beta-1	CACNB1	0.0038
6169	ATP-binding cassette sub-family A member 5	ABCA5	0.0037
3856	Fibroblast growth factor receptor 3	FGFR3	0.0037
6103	Arylamine N-acetyltransferase 1	NAT1	0.0037
634	Squalene monooxygenase	SQLE	0.0037
7196	Squalene monooxygenase	ERG1	0.0037
2283	Steroid Delta-isomerase	ksi	0.0037
2920	Steroid Delta-isomerase	ksi	0.0037
54	Prothrombin	F2	0.0037
6046	Voltage-gated calcium channel beta 1 subunit splice variant CavB1d	CACNB1	0.0036
558	Solute carrier family 12 member 1	SLC12A1	0.0036
705	Glutamate receptor 1	GRIA1	0.0036
185	Vasopressin V1a receptor	AVPR1A	0.0035
6048	Troponin C, skeletal muscle	TNNC2	0.0035
939	50S ribosomal protein L3	rplC	0.0035
1517	Beta-3 adrenergic receptor	ADRB3	0.0035
515	26S proteasome non-ATPase regulatory subunit 1	PSMD1	0.0034
522	26S proteasome non-ATPase regulatory subunit 2	PSMD2	0.0034
322	Vasopressin V2 receptor	AVPR2	0.0034
2325	Sulfotransferase family cytosolic 2B member 1	SULT2B1	0.0034
823	Fibroblast growth factor receptor 2	FGFR2	0.0034
5300	Antigen peptide transporter 1	TAP1	0.0034
951	Macrophage colony-stimulating factor 1 receptor	CSF1R	0.0034
6153	Solute carrier organic anion transporter family member 4A1	SLCO4A1	0.0034
2180	3-phosphoinositide-dependent protein kinase 1	PDPK1	0.0033
6043	Putative G-protein coupled receptor 44	GPR44	0.0033
6150	Solute carrier organic anion transporter family member 4C1	SLCO4C1	0.0033
6044	Serum paraoxonase/lactonase 3	PON3	0.0033
153	Dopamine beta-hydroxylase	DBH	0.0033
6040	6-phosphogluconate dehydrogenase, decarboxylating	PGD	0.0033
1561	Troponin C, slow skeletal and cardiac muscles	TNNC1	0.0033
5880	Thrombopoietin receptor	MPL	0.0033
610	Calcium-activated potassium channel subunit alpha 1	KCNMA1	0.0033
4311	tRNA	TRDMT1	0.0032
4325	tRNA	trmD	0.0032
4328	tRNA	trmD	0.0032
164	Histamine H4 receptor	HRH4	0.0032
137	FolC bifunctional protein [Includes: Folylpolyglutamate synthase	folC	0.0032
459	Retinoic acid receptor RXR-alpha	RXRA	0.0032
6174	50S ribosomal protein L32	rpmF	0.0032
140	30S ribosomal protein S9	rpsI	0.0031
6719	30S ribosomal protein S9	rpsI	0.0031
6725	30S ribosomal protein S9	rpsI	0.0031
276	Sodium- and chloride-dependent GABA transporter 1	SLC6A1	0.0031
5787	Angiopoietin-1 receptor	TEK	0.0031
1636	Trace amine-associated receptor 1	TAAR1	0.0031
1787	Nuclear factor NF-kappa-B p105 subunit	NFKB1	0.0031
1227	Cytochrome b	MT-CYB	0.0031
6386	Cytochrome b	petB	0.0031
6937	Cytochrome b	MT-CYB	0.0031
674	Dihydroorotate dehydrogenase homolog, mitochondrial	PFF0160c	0.0031
3868	Calcineurin subunit B isoform 2	PPP3R2	0.0031
421	Calcium signal-modulating cyclophilin ligand	CAMLG	0.0031
572	Integrin alpha-L	ITGAL	0.0031
217	Estradiol 17-beta-dehydrogenase 1	HSD17B1	0.0031
3913	Glutamic acid decarboxylase	GAD65	0.0031
280	4-aminobutyrate aminotransferase, mitochondrial	ABAT	0.0031
200	Carnitine O-palmitoyltransferase 2, mitochondrial	CPT2	0.0031
451	Carnitine O-palmitoyltransferase I, liver isoform	CPT1A	0.0031
2578	Tubulin beta-3 chain	TUBB3	0.003
2285	Streptogramin A acetyltransferase	vatD	0.003
741	Potassium voltage-gated channel subfamily KQT member 1	KCNQ1	0.003
719	Retinoic acid receptor responder protein 1	RARRES1	0.0029
770	Retinoic acid-induced protein 3	GPRC5A	0.0029
1992	Vitamin D-binding protein	GC	0.0029
6146	High affinity copper uptake protein 1	SLC31A1	0.0029
424	Dihydroorotate dehydrogenase, mitochondrial	DHODH	0.0029
368	Enoyl-[acyl-carrier-protein] reductase [NADH]	inhA	0.0028
3228	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0028
3678	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0028
6856	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0028
241	Calcium-transporting ATPase type 2C member 1	ATP2C1	0.0028
102	DNA topoisomerase I, mitochondrial	TOP1MT	0.0028
1200	AMBP protein	AMBP	0.0028
3866	Serum amyloid A protein	SAA1	0.0028
1932	Apolipoprotein E	APOE	0.0028
6206	DNA-directed RNA polymerase subunit beta'	rpoC	0.0028
139	Aldo-keto reductase family 1 member C1	AKR1C1	0.0027
1144	Hepatocyte growth factor receptor	MET	0.0027
2449	Tubulin alpha-3 chain	TUBA1A	0.0027
4173	Tyrosine-protein kinase JAK2	JAK2	0.0027
4103	Proteasome subunit beta type 2	PSMB2	0.0027
2159	Quinone oxidoreductase	CRYZ	0.0027
4102	Proteasome subunit beta type 5	PSMB5	0.0027
4101	Proteasome subunit beta type 1	PSMB1	0.0027
5934	Cytochrome P450 26A1	CYP26A1	0.0027
239	Coagulation factor X	F10	0.0027
4228	Keratin, type II cytoskeletal 7	KRT7	0.0027
537	ATP synthase delta chain, mitochondrial	ATP5D	0.0027
2184	Cystic fibrosis transmembrane conductance regulator	CFTR	0.0026
751	Potassium channel subfamily K member 6	KCNK6	0.0026
6432	Transporter	snf	0.0026
243	Ribosyldihydronicotinamide dehydrogenase [quinone]	NQO2	0.0026
3904	Alanine aminotransferase 2	GPT2	0.0026
735	Alanine aminotransferase 1	GPT	0.0026
6080	Neuronal acetylcholine receptor subunit alpha-5	CHRNA5	0.0026
6082	Neuronal acetylcholine receptor subunit beta-3	CHRNB3	0.0026
948	Neuronal acetylcholine receptor subunit beta-2	CHRNB2	0.0026
569	Retinal dehydrogenase 2	ALDH1A2	0.0025
267	Plasminogen activator inhibitor 1	SERPINE1	0.0025
559	NADH-ubiquinone oxidoreductase chain 1	MT-ND1	0.0025
3639	Thymidine phosphorylase	deoA	0.0025
3936	Thymidine phosphorylase	TYMP	0.0025
7	Nitric oxide synthase, inducible	NOS2	0.0025
563	Thyroid peroxidase	TPO	0.0025
6033	High affinity interleukin-8 receptor A	CXCR1	0.0025
2157	NAD(P)H dehydrogenase [quinone] 1	NQO1	0.0025
904	Glutathione S-transferase P	GSTP1	0.0025
6179	UDP-glucuronosyltransferase 2B17	UGT2B17	0.0024
1971	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	PDE4A	0.0024
172	Potassium channel subfamily K member 1	KCNK1	0.0024
1302	Dihydropyrimidine dehydrogenase [NADP+]	DPYD	0.0024
544	Potassium voltage-gated channel subfamily E member 1	KCNE1	0.0024
6039	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	PDE11A	0.0024
611	Retinal dehydrogenase 1	ALDH1A1	0.0024
233	Potassium channel subfamily K member 2	KCNK2	0.0024
229	Retinoic acid receptor beta	RARB	0.0024
5852	Type-2 angiotensin II receptor	AGTR2	0.0024
6081	Neuronal acetylcholine receptor subunit alpha-6	CHRNA6	0.0024
1524	Peptidyl-prolyl cis-trans isomerase A	PPIA	0.0024
6700	Peptidyl-prolyl cis-trans isomerase A	ppiA	0.0024
4097	Neuronal acetylcholine receptor subunit alpha-9	CHRNA9	0.0024
1525	Heparin-binding growth factor 2	FGF2	0.0023
730	Retinoic acid receptor alpha	RARA	0.0023
1341	Histamine H3 receptor	HRH3	0.0023
1353	DNA topoisomerase 1	TOP1	0.0023
3552	DNA topoisomerase 1	topA	0.0023
564	Cellular retinoic acid-binding protein 1	CRABP1	0.0023
6221	Steroid hormone receptor ERR1	ESRRA	0.0023
543	Penicillin-binding protein 1B	mrcB	0.0023
6186	Penicillin-binding protein 1B	ponB	0.0023
6822	Penicillin-binding protein 1b	pbp1b	0.0023
6844	Penicillin-binding protein 1b	pbp1b	0.0023
1864	RET proto-oncogene	RET	0.0023
268	Adenosine A2b receptor	ADORA2B	0.0023
1950	Epithelial discoidin domain-containing receptor 1	DDR1	0.0022
6170	ATP-binding cassette sub-family A member 3	ABCA3	0.0022
6094	BCR/ABL fusion protein isoform X9	BCR/ABL fusion	0.0022
2981	Phospholipase A2, membrane associated	PLA2G2A	0.0022
6152	Solute carrier organic anion transporter family member 2A1	SLCO2A1	0.0022
159	Penicillin-binding protein 2B	penA	0.0022
6121	Penicillin-binding protein 2B	penA	0.0022
859	Cellular retinoic acid-binding protein 2	CRABP2	0.0022
3404	Exotoxin A	eta	0.0022
259	Microsomal triglyceride transfer protein large subunit	MTTP	0.0022
2232	Interleukin-5	IL5	0.0022
6824	Tyrosine-protein kinase Lyn	LYN	0.0021
298	Renin	REN	0.0021
1593	Mucin-2	MUC2	0.0021
6140	Ileal sodium/bile acid cotransporter	SLC10A2	0.0021
6149	Solute carrier family 22 member 10	SLC22A10	0.0021
73	Prostaglandin E2 receptor, EP1 subtype	PTGER1	0.0021
63	Malate dehydrogenase	mdh	0.0021
2329	Malate dehydrogenase	mdh	0.0021
3445	Malate dehydrogenase	mdh	0.0021
4420	Malate dehydrogenase	mdh	0.0021
4438	Malate dehydrogenase	mdh	0.0021
3802	Sodium channel protein type 2 subunit alpha	SCN2A	0.002
3937	Fatty-acid amide hydrolase	FAAH	0.002
594	Thyroxine-binding globulin	SERPINA7	0.002
3611	Cytidine deaminase	cdd	0.002
3707	Cytidine deaminase	cdd	0.002
4211	Cytidine deaminase	CDA	0.002
4217	Telomerase reverse transcriptase	TERT	0.002
2450	Tyrosine-protein kinase ITK/TSK	ITK	0.0019
633	Penicillin-binding proteins 1A/1B	pbpA	0.0019
2216	Fibroblast growth factor receptor 4	FGFR4	0.0019
2499	Tubulin beta-2C chain	TUBB2C	0.0019
5766	NAD-dependent deacetylase sirtuin-5	SIRT5	0.0019
473	L-lactate dehydrogenase A chain	LDHA	0.0019
758	Thyroid hormone receptor alpha	THRA	0.0019
893	[Citrate [pro-3S]-lyase] ligase	citC	0.0018
845	Pyruvate dehydrogenase [cytochrome]	poxB	0.0018
5998	Toll-like receptor 8	TLR8	0.0018
712	Tubulin alpha chain	TUB1	0.0018
1968	ATP-sensitive inward rectifier potassium channel 12	KCNJ12	0.0018
327	Glutathione reductase	gor	0.0018
5110	Glutathione reductase	GR2	0.0018
683	Potassium transporter	GK0582	0.0018
748	5'-AMP-activated protein kinase catalytic subunit alpha-1	PRKAA1	0.0018
1123	Eosinophil cationic protein	RNASE3	0.0018
199	Monocarboxylate transporter 8	SLC16A2	0.0018
67	Prolyl 4-hydroxylase subunit alpha-1	P4HA1	0.0017
613	Atrial natriuretic peptide receptor A	NPR1	0.0017
245	Large neutral amino acids transporter small subunit 1	SLC7A5	0.0017
2290	ADP-ribosyl cyclase 2	BST1	0.0017
1374	Natriuretic peptides B	NPPB	0.0017
1827	Gap junction alpha-1 protein	GJA1	0.0017
1908	Vascular cell adhesion protein 1	VCAM1	0.0017
106	Cannabinoid receptor 2	CNR2	0.0017
992	Protein tyrosine kinase 2 beta	PTK2B	0.0017
514	Potassium voltage-gated channel subfamily H member 6	KCNH6	0.0017
772	Potassium voltage-gated channel subfamily H member 7	KCNH7	0.0017
346	Thyroid hormone receptor beta-1	THRB	0.0017
144	Hemoglobin subunit alpha	HBA1	0.0016
511	5-hydroxytryptamine 1F receptor	HTR1F	0.0016
4226	Uridine phosphorylase 2	UPP2	0.0016
5798	Mitogen-activated protein kinase 11	MAPK11	0.0016
2207	Rhodopsin	RHO	0.0016
3233	Bile acid receptor	NR1H4	0.0015
2320	Thymidine kinase, cytosolic	TK1	0.0015
936	Ephrin type-A receptor 2	EPHA2	0.0015
2853	14 kDa fatty acid-binding protein	Not Available	0.0015
3126	Poly [ADP-ribose] polymerase 1	PARP1	0.0015
982	Cocaine- and amphetamine-regulated transcript protein	CARTPT	0.0015
3957	Adenosine deaminase	ADA	0.0015
806	Sodium/potassium-transporting ATPase alpha-1 chain	ATP1A1	0.0015
4225	Uridine phosphorylase 1	UPP1	0.0015
933	Proto-oncogene tyrosine-protein kinase Src	SRC	0.0015
194	NADH dehydrogenase [ubiquinone] 1 subunit C2	NDUFC2	0.0015
489	Monocarboxylate transporter 2	SLC16A7	0.0014
6155	ATP-binding cassette transporter sub-family C member 11	ABCC11	0.0014
591	Glutamate [NMDA] receptor subunit 3B	GRIN3B	0.0014
2599	Tyrosine-protein kinase HCK	HCK	0.0014
760	Fibroblast growth factor 1	FGF1	0.0014
6032	PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE)	fas	0.0014
6218	Pannexin-1	PANX1	0.0014
413	Amidophosphoribosyltransferase	PPAT	0.0014
2515	Amidophosphoribosyltransferase	purF	0.0014
3714	Amidophosphoribosyltransferase	purF	0.0014
1039	Histone deacetylase 9	HDAC9	0.0013
2021	Thrombomodulin	THBD	0.0013
937	Proto-oncogene tyrosine-protein kinase LCK	LCK	0.0013
244	Angiotensin-converting enzyme	ACE	0.0013
6211	Tubulin epsilon chain	TUBE1	0.0013
6212	Tubulin gamma-1 chain	TUBG1	0.0013
6210	Tubulin delta chain	TUBD1	0.0013
6123	Carbonic anhydrase 5A, mitochondrial	CA5A	0.0013
860	Nicotinamide N-methyltransferase	NNMT	0.0013
699	Nicotinic acid receptor 1	GPR109A	0.0013
928	Nicotinic acid receptor 2	GPR109B	0.0013
583	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	QPRT	0.0013
2442	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	nadC	0.0013
2459	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	nadC	0.0013
908	Glutathione S-transferase theta-1	GSTT1	0.0013
6116	Gastric triacylglycerol lipase	LIPF	0.0012
4192	DNA topoisomerase 2-beta	TOP2B	0.0012
3806	cGMP-dependent 3',5'-cyclic phosphodiesterase	PDE2A	0.0012
3823	Cytokine receptor common gamma chain	IL2RG	0.0012
85	Growth hormone receptor	GHR	0.0012
2107	Microtubule-associated protein 1A	MAP1A	0.0012
338	DNA polymerase	UL30	0.0012
379	DNA polymerase	UL54	0.0012
697	DNA polymerase	ORF28	0.0012
2482	DNA polymerase	43	0.0012
4104	DNA polymerase	BALF5	0.0012
1768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit	GNG2	0.0012
1295	Fatty acid synthase	FASN	0.0012
1268	Neuropeptide S receptor	NPSR1	0.0012
1571	G protein-activated inward rectifier potassium channel 1	KCNJ3	0.0012
1581	G protein-activated inward rectifier potassium channel 2	KCNJ6	0.0012
6931	Calcium-activated potassium channel subunit beta-1	KCNMB1	0.0012
6933	Calcium-activated potassium channel subunit beta-4	KCNMB4	0.0012
6932	Calcium-activated potassium channel subunit beta-3	KCNMB3	0.0012
6934	Small conductance calcium-activated potassium channel protein 1	KCNN1	0.0012
6935	Small conductance calcium-activated potassium channel protein 2	KCNN2	0.0012
6936	Small conductance calcium-activated potassium channel protein 3	KCNN3	0.0012
605	Fumarate reductase flavoprotein subunit	frdA	0.0012
2709	Fumarate reductase flavoprotein subunit	SO_0970	0.0012
3673	Fumarate reductase flavoprotein subunit	fccA	0.0012
4912	Fumarate reductase flavoprotein subunit	ifcA	0.0012
6549	Fumarate reductase flavoprotein subunit	frdA	0.0012
5433	UPF0230 protein TM_1468	TM_1468	0.0012
5431	Lipid binding protein	Not Available	0.0012
3616	Fatty acid-binding protein, epidermal	FABP5	0.0012
5430	Hepatocyte nuclear factor 4-gamma	HNF4G	0.0012
182	2-oxoglutarate dehydrogenase E1 component, mitochondrial	OGDH	0.0012
630	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial	ACADSB	0.0012
6164	POU domain, class 5, transcription factor 1	POU5F1	0.0011
389	Amiloride-sensitive cation channel 2, neuronal	ACCN2	0.0011
754	Pancreatic triacylglycerol lipase	PNLIP	0.0011
707	72 kDa type IV collagenase	MMP2	0.0011
4162	Potassium voltage-gated channel subfamily KQT member 3	KCNQ3	0.0011
291	Nitric-oxide synthase, endothelial	NOS3	0.0011
6073	Potassium channel subfamily K member 9	KCNK9	0.0011
6072	Potassium channel subfamily K member 3	KCNK3	0.0011
896	Glutathione S-transferase Mu 1	GSTM1	0.0011
2178	Metabotropic glutamate receptor 5	GRM5	0.0011
724	Interleukin-2 receptor alpha chain	IL2RA	0.0011
717	Interleukin-2 receptor subunit beta	IL2RB	0.0011
5463	Calcium-activated potassium channel subunit beta 2	KCNMB2	0.001
2300	Lysozyme	E	0.001
3633	Lysozyme	R	0.001
5597	Lysozyme	17	0.001
3917	Methylenetetrahydrofolate reductase	MTHFR	0.001
1810	Protein S100-A1	S100A1	0.001
6097	Protein S100-A2	S100A2	0.001
838	Inosine-5'-monophosphate dehydrogenase 1	IMPDH1	0.001
796	Inosine-5'-monophosphate dehydrogenase 2	IMPDH2	0.001
170	Succinate semialdehyde dehydrogenase, mitochondrial	ALDH5A1	0.001
493	25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	CYP27B1	0.001
695	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	PDE10A	0.001
283	SEC14-like protein 2	SEC14L2	0.001
734	D1 dopamine receptor-interacting protein calcyon	CALY	0.001
512	DNA-directed RNA polymerase alpha chain	rpoA	0.001
5772	DNA-directed RNA polymerase alpha chain	rpoA	0.001
4041	Microsomal glutathione S-transferase 2	MGST2	0.001
6151	Monocarboxylate transporter 10	SLC16A10	0.001
251	Alcohol dehydrogenase 1A	ADH1A	0.001
6837	Serine/threonine-protein kinase 17B	STK17B	0.001
6836	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial	HIBCH	0.001
4948	Cytochrome c-553	Not Available	0.001
4923	Cytochrome c3	DvMF_2499	0.001
4945	Cytochrome c3	Not Available	0.001
4949	Cytochrome c3	DVU_3171	0.001
4968	Cytochrome c3	cytc3	0.001
4997	Cytochrome c3	SO_2727	0.001
5219	Cytochrome c3	cyd	0.001
4902	Nine-heme cytochrome c	Ddes_2038	0.001
3189	High-molecular-weight cytochrome c	hmcA	0.001
5432	Trafficking protein particle complex subunit 3	TRAPPC3	0.0009
2211	Fatty acid-binding protein, heart	FABP3	0.0009
6459	Glycodelin	PAEP	0.0009
1064	DNA (cytosine-5)-methyltransferase 1	DNMT1	0.0009
820	Glycine receptor subunit alpha-2	GLRA2	0.0009
65	Matrix metalloproteinase-9	Not Available	0.0009
1792	Tissue-type plasminogen activator	PLAT	0.0009
828	Phenylalanine-4-hydroxylase	PAH	0.0009
3109	Phenylalanine-4-hydroxylase	phhA	0.0009
1048	Protein S100-A13	S100A13	0.0009
2226	Protein S100-A12	S100A12	0.0009
1759	85 kDa calcium-independent phospholipase A2	PLA2G6	0.0009
1770	Phospholipase C	PLCL1	0.0009
2841	Phospholipase C	plc	0.0009
6677	Myelin P2 protein	PMP2	0.0009
6131	Carbonic anhydrase 14	CA14	0.0009
33	Cystine/glutamate transporter	SLC7A11	0.0009
444	Alcohol dehydrogenase 1B	ADH1B	0.0009
390	Adenosine A3 receptor	ADORA3	0.0009
2132	Protein S100-B	S100B	0.0009
382	Glutamate receptor, ionotropic kainate 1	GRIK1	0.0008
3961	G protein-activated inward rectifier potassium channel 4	KCNJ5	0.0008
6656	UDP-glucuronosyltransferase 3A1	UGT3A1	0.0008
2298	Cytochrome P450-cam	camC	0.0008
22	30S ribosomal protein S4	rpsD	0.0008
6714	30S ribosomal protein S4	rpsD	0.0008
6122	Carbonic anhydrase 3	CA3	0.0008
4386	Hemoglobin-like protein HbN	glbN	0.0008
1867	Major prion protein	PRNP	0.0008
4031	Glutathione S-transferase A1	GSTA1	0.0008
6599	HTH-type transcriptional regulator ttgR	ttgR	0.0008
500	Monocarboxylate transporter 4	SLC16A3	0.0008
1649	Small inducible cytokine A2	CCL2	0.0008
1025	Aquaporin-1	AQP1	0.0008
517	Alcohol dehydrogenase 1C	ADH1C	0.0008
3830	Calreticulin	CALR	0.0008
2091	Endoplasmin	HSP90B1	0.0008
6893	Calcium/calmodulin-dependent protein kinase type II gamma chain	CAMK2G	0.0007
3221	Cytochrome c4	cc4	0.0007
866	Large neutral amino acids transporter small subunit 2	SLC7A8	0.0007
461	Glycine receptor subunit alpha-3	GLRA3	0.0007
521	ATP-binding cassette transporter sub-family C member 9	ABCC9	0.0007
6034	Hydroxyindole O-methyltransferase	ASMT	0.0007
6035	Nuclear receptor ROR-beta	RORB	0.0007
6036	Eosinophil peroxidase	EPX	0.0007
6344	ATP synthase subunit gamma, mitochondrial	ATP5C1	0.0007
6343	ATP synthase subunit beta, mitochondrial	ATP5B	0.0007
6342	ATP synthase subunit alpha, mitochondrial	ATP5A1	0.0007
6207	30S ribosomal protein S14	rpsN	0.0007
6209	30S ribosomal protein S19	rpsS	0.0007
6712	30S ribosomal protein S19	rpsS	0.0007
6726	30S ribosomal protein S19	rpsS	0.0007
645	Penicillin-binding protein 1A	mrcA	0.0007
5805	Penicillin-binding protein 1A	ponA	0.0007
6185	Penicillin-binding protein 1A	mrcA	0.0007
6799	Penicillin-binding protein 1A	pbpA	0.0007
3876	Aromatic-L-amino-acid decarboxylase	DDC	0.0007
226	Gonadotropin-releasing hormone receptor	GNRHR	0.0007
1830	5'-nucleotidase	NT5E	0.0007
6172	ATP-binding cassette sub-family B member 8, mitochondrial	ABCB8	0.0007
125	DNA polymerase beta	POLB	0.0007
132	ATP-binding cassette sub-family A member 1	ABCA1	0.0007
1360	Sphingomyelin phosphodiesterase	SMPD1	0.0006
1507	Cytochrome c	CYCS	0.0006
6259	(3R)-hydroxymyristoyl-acyl carrier protein dehydratase	fabZ	0.0006
364	Corticosteroid 11-beta-dehydrogenase isozyme 1	HSD11B1	0.0006
765	Indoleamine 2,3-dioxygenase	IDO1	0.0006
3426	Glutamine synthetase	glnA	0.0006
3987	Glutamine synthetase	GLUL	0.0006
890	Niemann-Pick C1-like protein 1	NPC1L1	0.0006
2404	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PIK3CG	0.0006
6167	Organic solute transporter subunit beta	OSTB	0.0006
6166	Organic solute transporter subunit alpha	OSTA	0.0006
337	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial	NDUFS7	0.0006
214	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	NDUFS3	0.0006
803	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	NDUFS2	0.0006
6168	Solute carrier family 22 member 16	SLC22A16	0.0006
76	Nitric-oxide synthase, brain	NOS1	0.0006
6861	Alcohol dehydrogenase [NADP+]	AKR1A1	0.0006
1569	G1/S-specific cyclin-D1	CCND1	0.0006
5221	Cytochrome c3, 13 kDa	Not Available	0.0006
3152	Cytochrome c''	cycA	0.0006
5220	Split-Soret cytochrome c	Ddes_2150	0.0006
3700	Cytochrome c-552 precursor	nrfA	0.0006
1760	Aminopeptidase N	ANPEP	0.0005
6843	Aminopeptidase N	pepN	0.0005
117	Sterol O-acyltransferase 1	SOAT1	0.0005
2347	Proto-oncogene serine/threonine-protein kinase Pim-1	PIM1	0.0005
1939	Heat shock protein HSP 90-alpha	HSP90AA1	0.0005
4954	Soluble cytochrome b558	Not Available	0.0005
4916	Cyanoglobin	glbN	0.0005
4947	Bacterial hemoglobin	vhb	0.0005
4915	Cytochrome c-550	psbV	0.0005
4959	Cytochrome c-550	psbV	0.0005
5216	Cytochrome c-550	psbV	0.0005
4925	Cytochrome c-type protein SHP	shp	0.0005
4934	Cytochrome c-551	nirM	0.0005
5218	Cytochrome c-551	nirM	0.0005
4936	Cytochrome c2 iso-2	Not Available	0.0005
4943	Cytochrome c6	petJ	0.0005
4975	Cytochrome c-556	RPA3973	0.0005
4905	Cytochrome c2	Not Available	0.0005
4939	Cytochrome c2	cycA	0.0005
4964	Cytochrome c2	cycA	0.0005
4979	Cytochrome c2	cycA	0.0005
6673	Cytochrome c2	cycA	0.0005
4998	Hemoglobin-like protein yjbI	yjbI	0.0005
4994	Hemoglobin-like protein HbO	glbO	0.0005
5000	HemO	hemO	0.0005
4984	Neuroglobin	NGB	0.0005
4909	CooA protein	cooA	0.0005
4904	Cytochrome c family protein	GSU1996	0.0005
4910	Cytoglobin	CYGB	0.0005
4961	Hemophore HasA	hasA	0.0005
3116	Bacterioferritin	bfr	0.0005
4906	Bacterioferritin	bfr	0.0005
4965	Bacterioferritin	bfr	0.0005
4981	Iron-starvation protein PigA	pigA	0.0005
4935	Cytochrome c-554	cycA1	0.0005
4942	Diheme cytochrome c napB	napB	0.0005
4971	Nonaheme cytochrome c	hmcA	0.0005
644	Heme oxygenase 2	HMOX2	0.0005
4982	Heme oxygenase 2	pbsA2	0.0005
4907	Cytochrome c-L	moxG	0.0005
6865	Cytochrome c-L	moxG	0.0005
4989	Cytochrome c551 peroxidase	ccp	0.0005
5222	Cytochrome c551 peroxidase	ccpA	0.0005
4976	Apocytochrome f	petA	0.0005
6407	Apocytochrome f	petA	0.0005
4937	Cytochrome oxidase subunit II	rcoxA	0.0005
4764	Cytochrome P450 165C4	CYP165C4	0.0005
4931	Cytochrome P450 167A1	CYP167A1	0.0005
4999	Cytochrome P450 165B3	CYP165B3	0.0005
4960	Putative cytochrome P450-family protein	SCO7417	0.0005
4922	Cytochrome c, putative	SO_4144	0.0005
4926	Heme-based aerotactic transducer hemAT	hemAT	0.0005
4903	Methyl-accepting chemotaxis protein	Tar4	0.0005
4970	Cytochrome c nitrite reductase catalytic subunit	nrfA	0.0005
4993	Hydroxylamine oxidoreductase	hao1	0.0005
4972	P450cin	cinA	0.0005
4952	Catalase/peroxidase	katA	0.0005
3093	Catalase HPII	katE	0.0005
4908	Heme-regulated cyclic AMP phosphodiesterase	dosP	0.0005
3127	Nitrite reductase	nirS	0.0005
3284	Nitrite reductase	nirS	0.0005
1714	Mitogen-activated protein kinase 3	MAPK3	0.0005
2236	Casein kinase II subunit alpha	CSNK2A1	0.0005
3610	Thioredoxin reductase 1, cytoplasmic	TXNRD1	0.0004
2038	Inhibitor of nuclear factor kappa-B kinase subunit beta	IKBKB	0.0004
476	RAC-alpha serine/threonine-protein kinase	AKT1	0.0004
6161	Probable low affinity copper uptake protein 2	SLC31A2	0.0004
3405	Quinohaemoprotein ethanol dehydrogenase type-1	qheDH	0.0004
6042	Prostaglandin reductase 2	PTGR2	0.0004
6163	Copper-transporting ATPase 2	ATP7B	0.0004
6165	Copper-transporting ATPase 1	ATP7A	0.0004
935	Proto-oncogene tyrosine-protein kinase Yes	YES1	0.0004
1063	Signal transducer and activator of transcription 5B	STAT5B	0.0004
1176	Mitogen-activated protein kinase 1	MAPK1	0.0004
4152	Superoxide dismutase [Cu-Zn]	SOD1	0.0004
4920	Peroxidase/catalase	katG	0.0004
2119	Cytochrome b5	CYB5A	0.0004
4990	PpcA	ppcA	0.0004
4956	Quinohemoprotein alcohol dehydrogenase ADH IIB	qbdA	0.0004
3375	Acidic cytochrome c3	Not Available	0.0004
4988	Sulfite oxidase, mitochondrial	SUOX	0.0004
2915	Sensor protein fixL	fixL	0.0004
4944	Sensor protein fixL	fixL	0.0004
3570	Cytochrome P450 152A1	cypC	0.0004
4385	Cytochrome c'	Not Available	0.0004
4967	Cytochrome c'	cycA	0.0004
5038	Cytochrome c'	Not Available	0.0004
5223	Cytochrome c'	cycP	0.0004
4037	Hypothetical protein	GPX1	0.0004
4297	Hypothetical protein	SP_1951	0.0004
4521	Hypothetical protein	BC_2969	0.0004
4540	Hypothetical protein	TM_1070	0.0004
4555	Hypothetical protein	MT1739	0.0004
4569	Hypothetical protein	mshD	0.0004
4578	Hypothetical protein	PA3270	0.0004
4747	Hypothetical protein	PA3967	0.0004
5177	Hypothetical protein	TM_0096	0.0004
5194	Hypothetical protein	PA1204	0.0004
5240	Hypothetical protein	Rv2991	0.0004
5370	Hypothetical protein	TM_1158	0.0004
5710	Hypothetical protein	Tb927.5.1360	0.0004
4813	Heme oxygenase	hmuO	0.0004
5769	Heme oxygenase	Not Available	0.0004
4992	Cytochrome c peroxidase	Not Available	0.0004
4289	Cytochrome P450	TT_P0059	0.0004
6262	Cytochrome P450	staP	0.0004
2230	Catalase	CAT	0.0004
3249	Catalase	katA	0.0004
3625	Catalase	katA	0.0004
4539	Catalase	katA	0.0004
4941	Catalase	katB	0.0004
934	Proto-oncogene tyrosine-protein kinase Fyn	FYN	0.0004
484	Tyrosine-protein kinase ABL2	ABL2	0.0003
2240	Cell division protein kinase 2	CDK2	0.0003
3670	Soluble cytochrome b562 precursor	cybC	0.0003
3411	Cytochrome P450 121	cyp121	0.0003
3291	Cytochrome c-552	cycA	0.0003
4927	Cytochrome c-552	nrfA	0.0003
4938	Cytochrome c-552	cycA	0.0003
4953	Cytochrome c-552	nrfA	0.0003
5217	Cytochrome c-552	cycM	0.0003
2617	Nitric oxide synthase oxygenase	nos	0.0003
2701	Nitric oxide synthase oxygenase	nos	0.0003
3102	Flavohemoprotein	hmp	0.0003
4969	Flavohemoprotein	hmp	0.0003
1313	Lactoylglutathione lyase	GLO1	0.0003
2845	Bifunctional P-450:NADPH-P450 reductase	CYP102A1	0.0003
2972	6-deoxyerythronolide B hydroxylase	eryF	0.0003
4608	Putative cytochrome P450	SCO1207	0.0003
4963	Putative cytochrome P450	SCO2884	0.0003
6254	Putative cytochrome P450	SCO6998	0.0003
358	Cystathionine beta-synthase	CBS	0.0002
693	Hemoglobin subunit beta	HBB	0.0002
6268	Hydroxyacid oxidase 1	HAO1	0.0002
6135	Sodium channel subunit beta-4	SCN4B	0.0002
6134	Sodium channel subunit beta-3	SCN3B	0.0002
6132	Sodium channel subunit beta-1	SCN1B	0.0002
6127	Carbonic anhydrase-related protein	CA8	0.0002
6128	Carbonic anhydrase-related protein 10	CA10	0.0002
6133	Sodium channel subunit beta-2	SCN2B	0.0002
6129	Carbonic anhydrase-related protein 11	CA11	0.0002
810	Heme oxygenase 1	HMOX1	0.0002
3391	Heme oxygenase 1	pbsA1	0.0002
3803	Sodium channel protein type 3 subunit alpha	SCN3A	0.0002
6130	Carbonic anhydrase 13	CA13	0.0002
6124	Carbonic anhydrase 5B, mitochondrial	CA5B	0.0002
6160	Solute carrier organic anion transporter family member 3A1	SLCO3A1	0.0002
3007	Carbonic anhydrase 12	CA12	0.0002
4205	Carbonic anhydrase 9	CA9	0.0002

(*) Categorization taken from DrugBank: therapeutic category or general category of a drug (i.e. anti-convulsant, antibacterial, etc.)

DB00647 - Propoxyphene

Targets

Enzymes

Predictions