DT-Web

DB00046 - Insulin Lispro


Identification
Name Insulin Lispro
Accession Number DB00046 (BIOD00065, BTD00065, DB01310)
Type biotech
Description Insulin lispro is a recombinant human insulin analogue produced in a specialized laboratory strain of Escherischia coli. Plasmid DNA transfected into the bacteria encodes for an analogue of human insulin that has a lysine at residuce B28 and proline at B29; these residues are reversed in endogenous human insulin. Reversal of these amino acid residues produces a rapid-acting insulin analogue. FDA approved on 1996.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 5808.0000
Groups approved
Monoisotopic Weight Not Available
Pharmacology
Indication For the treatment of Type 1 or 2 diabetes mellitus. To be used in conjunction with an intermediate or long-acting insulin except when used in a continuous insulin infusion pump.
Mechanism of action Insulin lispro binds to the insulin receptor (IR), a heterotetrameric protein consisting of two extracellular alpha units and two transmembrane beta units. The binding of insulin to the alpha subunit of IR stimulates the tyrosine kinase activity intrinsic to the beta subunit of the receptor. The bound receptor autophosphorylates and phosphorylates numerous intracellular substrates such as insulin receptor substrates (IRS) proteins, Cbl, APS, Shc and Gab 1. Activation of these proteins leads to the activation of downstream signaling molecules including PI3 kinase and Akt. Akt regulates the activity of glucose transporter 4 (GLUT4) and protein kinase C (PKC), both of which play critical roles in metabolism and catabolism. In humans, insulin is stored in the form of hexamers; however, only insulin monomers are able to interact with IR. Reversal of the proline and lysine residues at positions B28 and B29 of native insulin eliminates hydrophobic interactions and weakens some of the hydrogen bonds that contribute to the stability of the insulin dimers that comprise insulin hexamers. Hexamers of insulin lispro are produced in the presence of zinc and m-cresol. These weakly associated hexamers quickly dissociate upon subcutaneous injection and are absorbed as monomers through vascular endothelial cells. These properties give insulin lispro its fast-acting properties.
Absorption Rapidly absorbed following subcutaneous administration. It is also absorbed more quickly than regular human insulin. Peak serum levels occur 30-90 minutes after injection in healthy subjects. Absorption also differs depending on the site of injection. After insulin lispro was administered in the abdomen, serum drug levels were higher and the duration of action was slightly shorter than after deltoid or thigh administration. Bioavailability, 0.1 - 0.2 unit/kg = 55% - 77%.
Protein binding Not Available
Biotransformation Insulin is predominantly cleared by metabolic degradation via a receptor-mediated process.
Route of elimination Not Available
Toxicity Inappropriately high dosages relative to food intake and/or energy expenditure may result in severe and sometimes prolonged and life-threatening hypoglycemia. Neurogenic (autonomic) signs and symptoms of hypoglycemia include trembling, palpitations, sweating, anxiety, hunger, nausea and tingling. Neuroglycopenic signs and symptoms of hypoglycemia include difficulty concentrating, lethargy/weakness, confusion, drowsiness, vision changes, difficulty speaking, headache, and dizziness. Mild hypoglycemia is characterized by the presence of autonomic symptoms. Moderate hypoglycemia is characterized by the presence of autonomic and neuroglycopenic symptoms. Individuals may become unconscious in severe cases of hypoglycemia. Rare cases of lipoatrophy or lipohypertrophy reactions have been observed.
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Acebutolol The beta-blocker, acebutolol, may decrease symptoms of hypoglycemia.
Atenolol The beta-blocker, atenolol, may decrease symptoms of hypoglycemia.
Bisoprolol The beta-blocker, bisoprolol, may decrease symptoms of hypoglycemia.
Carvedilol The beta-blocker, carvedilol, may decrease symptoms of hypoglycemia.
Disopyramide Concomitant therapy with drugs that may increase the blood-glucose-lowering effect of insulin lispro and thus the chance of hypoglycemia should be monitored closely.
Enalapril Concomitant therapy with ACE inhibitors may increase the blood-glucose-lowering effect of insulin lispro and thus the chance of hypoglycemia should be monitored closely.
Epinephrine Concomitant therapy with sympathomimetic agents may reduce the blood-glucose-lowering effect of insulin lispro.
Esmolol The beta-blocker, esmolol, may decrease symptoms of hypoglycemia.
Fenofibrate Concomitant therapy with drugs that may increase the blood-glucose-lowering effect of insulin lispro and thus the chance of hypoglycemia should be monitored closely.
Fluoxetine Concomitant therapy with drugs that may increase the blood-glucose-lowering effect of insulin lispro and thus the chance of hypoglycemia should be monitored closely.
Hydrochlorothiazide Concomitant therapy with diuretics may reduce the blood-glucose-lowering effect of insulin lispro.
Losartan Concomitant therapy with angiotensin II receptor blockers may increase the blood-glucose-lowering effect of insulin lispro and thus the chance of hypoglycemia should be monitored closely.
Octreotide Concomitant therapy with somatostatin analogs may increase the blood-glucose-lowering effect of insulin lispro and thus the chance of hypoglycemia should be monitored closely.
Pentoxifylline Concomitant therapy with drugs that may increase the blood-glucose-lowering effect of insulin lispro and thus the chance of hypoglycemia should be monitored closely.
Pramlintide Concomitant therapy with drugs that may increase the blood-glucose-lowering effect of insulin lispro and thus the chance of hypoglycemia should be monitored closely.
Prednisone Concomitant therapy with corticosteriods may reduce the blood-glucose-lowering effect of insulin lispro.
Propoxyphene Concomitant therapy with drugs that may increase the blood-glucose-lowering effect of insulin lispro and thus the chance of hypoglycemia should be monitored closely.
Ramipril Concomitant therapy with ACE inhibitors may increase the blood-glucose-lowering effect of insulin lispro and thus the chance of hypoglycemia should be monitored closely.
Food Interactions
  • Inject subcutaneuosly 15 minutes before meal

Targets


Insulin receptor
Name Insulin receptor
Gene Name INSR
Pharmacological action yes
Actions agonist
References
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
  • Jehle PM, Fussgaenger RD, Kunze U, Dolderer M, Warchol W, Koop I: The human insulin analog insulin lispro improves insulin binding on circulating monocytes of intensively treated insulin-dependent diabetes mellitus patients. J Clin Endocrinol Metab. 1996 Jun;81(6):2319-27. - Pubmed
  • Jehle PM, Fussganger RD, Seibold A, Luttke B, Bohm BO: Pharmacodynamics of insulin Lispro in 2 patients with type II diabetes mellitus. Int J Clin Pharmacol Ther. 1996 Nov;34(11):498-503. - Pubmed
  • Sciacca L, Cassarino MF, Genua M, Pandini G, Le Moli R, Squatrito S, Vigneri R: Insulin analogues differently activate insulin receptor isoforms and post-receptor signalling. Diabetologia. 2010 Apr 28. - Pubmed
DTHybrid score 0.9157
Insulin-like growth factor 1 receptor
Name Insulin-like growth factor 1 receptor
Gene Name IGF1R
Pharmacological action unknown
Actions Not Available
References
  • Smith TJ: Insulin-like growth factor-I regulation of immune function: a potential therapeutic target in autoimmune diseases? Pharmacol Rev. 2010 Jun;62(2):199-236. Epub 2010 Apr 14. - Pubmed
DTHybrid score 0.874

Enzymes


Cytochrome P450 1A2
Name Cytochrome P450 1A2
Gene Name CYP1A2
Actions inducer
References
DTHybrid score 0.4434

Predictions


Id Partner name Gene Name Score
1350 Insulin-like growth factor-binding protein 3 IGFBP3 0.1358
6120 Cation-independent mannose-6-phosphate receptor IGF2R 0.1125
1372 Insulin receptor substrate 1 IRS1 0.0833
3849 Insulin-like growth factor-binding protein 7 IGFBP7 0.0729
3847 Neuroendocrine convertase 2 PCSK2 0.0728
2009 Protein NOV homolog NOV 0.0728
1949 Carboxypeptidase E CPE 0.0728
3850 Synaptotagmin-like protein 4 SYTL4 0.0728
3848 Neuroendocrine convertase 1 PCSK1 0.0728
3846 Retinoblastoma-associated protein RB1 0.0728
2155 Insulin-degrading enzyme IDE 0.0646
4512 Cytochrome P450 3A4 CYP3A4 0.064
1244 Low-density lipoprotein receptor-related protein 2 LRP2 0.0616
1243 Cathepsin D CTSD 0.0577
4119 Cytochrome P450 2D6 CYP2D6 0.0492
1176 Mitogen-activated protein kinase 1 MAPK1 0.0487
4757 Cytochrome P450 2C9 CYP2C9 0.0467
6016 Cytochrome P450 2C19 CYP2C19 0.0429
587 Serum albumin ALB 0.0424
3844 HLA class II histocompatibility antigen, DQ(6) alpha chain HLA-DQA2 0.0403
6024 Cytochrome P450 1A1 CYP1A1 0.038
1588 Multidrug resistance protein 1 ABCB1 0.0302
6013 Cytochrome P450 2E1 CYP2E1 0.03
6030 Cytochrome P450 2B6 CYP2B6 0.027
4924 Cytochrome P450 2C8 CYP2C8 0.0262
4118 Cytochrome P450 3A5 CYP3A5 0.0244
2299 UDP-N-acetylmuramate--L-alanine ligase murC 0.0205
5312 Kinesin-like protein KIF1A KIF1A 0.0205
2615 Chemotaxis protein cheA cheA 0.0194
2817 Phosphoribosylglycinamide formyltransferase 2 purT 0.0179
6107 Cytochrome P450 3A7 CYP3A7 0.0177
5718 Cytochrome P450 2A6 CYP2A6 0.0176
2621 Thermoresistant gluconokinase gntK 0.0168
5466 Putative sugar kinase STM4066 0.0167
4517 Probable butyrate kinase 2 buk2 0.0167
2878 Probable serine/threonine-protein kinase pknB pknB 0.0167
20 Prostaglandin G/H synthase 1 PTGS1 0.0146
3669 Ribokinase rbsK 0.0146
2717 Folylpolyglutamate synthase fgs 0.0139
6390 Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 ATP2A1 0.0139
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0135
48 Pyridoxal kinase PDXK 0.0131
477 DNA topoisomerase 4 subunit A parC 0.0127
886 DNA topoisomerase 4 subunit A parC 0.0127
6226 DNA topoisomerase 4 subunit A parC 0.0127
404 DNA gyrase subunit A gyrA 0.0125
6224 DNA gyrase subunit A gyrA 0.0125
318 Alpha-2A adrenergic receptor ADRA2A 0.0116
492 Histamine H1 receptor HRH1 0.0108
502 5-hydroxytryptamine 2A receptor HTR2A 0.0107
3941 Amine oxidase [flavin-containing] A MAOA 0.0102
831 D(2) dopamine receptor DRD2 0.01
817 DNA topoisomerase 2-alpha TOP2A 0.0096
290 Prostaglandin G/H synthase 2 PTGS2 0.009
556 Alpha-1A adrenergic receptor ADRA1A 0.009
885 5-hydroxytryptamine 1B receptor HTR1B 0.009
23 D(1A) dopamine receptor DRD1 0.0089
1898 Cytochrome P450 1B1 CYP1B1 0.0088
3811 Cytochrome P450 19A1 CYP19A1 0.0086
6145 Solute carrier family 22 member 1 SLC22A1 0.0084
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0083
824 Sodium-dependent serotonin transporter SLC6A4 0.0082
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0081
590 5-hydroxytryptamine 2C receptor HTR2C 0.0079
1729 Solute carrier family 22 member 6 SLC22A6 0.0078
725 5-hydroxytryptamine 1D receptor HTR1D 0.0077
6106 Cytochrome P450 2C18 CYP2C18 0.0076
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0076
118 Organic cation/carnitine transporter 2 SLC22A5 0.007
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0069
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0068
3939 Amine oxidase [flavin-containing] B MAOB 0.0067
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0066
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0066
16 Adenosine A1 receptor ADORA1 0.0066
6144 Solute carrier family 22 member 2 SLC22A2 0.0064
3794 Osmolarity sensor protein envZ envZ 0.0064
5644 Sensor protein phoQ phoQ 0.0064
5641 Rod shape-determining protein MreB TM_0588 0.0064
4178 DNA repair protein RAD51 homolog 1 RAD51 0.0064
5645 DNA topoisomerase 4 subunit B parE 0.0064
6227 DNA topoisomerase 4 subunit B parE 0.0064
5649 Potassium-transporting ATPase B chain kdpB 0.0064
5290 ATP-dependent hsl protease ATP-binding subunit hslU hslU 0.0064
5638 ATP-dependent hsl protease ATP-binding subunit hslU hslU 0.0064
5643 General secretion pathway protein E epsE 0.0064
5642 Chaperone clpB clpB 0.0064
193 Beta-1 adrenergic receptor ADRB1 0.0063
320 5-hydroxytryptamine 1A receptor HTR1A 0.0063
629 Alpha-2B adrenergic receptor ADRA2B 0.0062
632 Alpha-1B adrenergic receptor ADRA1B 0.0062
3923 Cholinesterase BCHE 0.0061
198 Sodium channel protein type 10 subunit alpha SCN10A 0.006
341 5-hydroxytryptamine 3 receptor HTR3A 0.006
2867 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase ispE 0.0056
3390 Aminoglycoside 3'-phosphotransferase aphA 0.0056
6029 Aminoglycoside 3'-phosphotransferase aphA1 0.0056
6433 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 PFKFB4 0.0056
5302 TrwB trwB 0.0056
2282 Protein recA recA 0.0056
2315 Protein recA recA 0.0056
2332 Protein recA recA 0.0056
5263 Protein recA recA 0.0056
2397 Dihydroxyacetone kinase dhaK 0.0056
4751 Mitogen-activated protein kinase 12 MAPK12 0.0056
5646 Galactokinase GALK1 0.0056
2852 DNA mismatch repair protein mutL mutL 0.0056
740 Argininosuccinate synthase ASS1 0.0056
865 Argininosuccinate synthase ASS1 0.0056
2680 Argininosuccinate synthase argG 0.0056
3194 Argininosuccinate synthase argG 0.0056
5265 FtsH ftsH 0.0056
862 Multidrug resistance-associated protein 1 ABCC1 0.0055
936 Ephrin type-A receptor 2 EPHA2 0.0055
4192 DNA topoisomerase 2-beta TOP2B 0.0053
1178 Adenosine A2a receptor ADORA2A 0.0053
638 D(3) dopamine receptor DRD3 0.0052
571 Melatonin receptor type 1A MTNR1A 0.0052
362 Melatonin receptor type 1B MTNR1B 0.0052
713 Sodium-dependent dopamine transporter SLC6A3 0.0052
4373 Medium-chain-fatty-acid--CoA ligase Not Available 0.0051
3231 Death-associated protein kinase 1 DAPK1 0.0051
789 Alpha-1D adrenergic receptor ADRA1D 0.0051
378 Alpha-2C adrenergic receptor ADRA2C 0.005
887 DNA gyrase subunit B gyrB 0.0049
4150 DNA gyrase subunit B gyrB 0.0049
6225 DNA gyrase subunit B gyrB 0.0049
136 Estrogen receptor ESR1 0.0049
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0049
2950 Inositol-trisphosphate 3-kinase A ITPKA 0.0048
2371 Pantothenate kinase coaA 0.0048
825 Arsenical pump-driving ATPase ASNA1 0.0048
3435 Arsenical pump-driving ATPase arsA 0.0048
2892 Acetylglutamate kinase argB 0.0048
3550 Acetylglutamate kinase argB 0.0048
1881 Hexokinase-1 HK1 0.0048
6832 Serine/threonine-protein kinase SRPK2 SRPK2 0.0047
766 Beta-2 adrenergic receptor ADRB2 0.0047
2727 S-adenosylmethionine synthetase metK 0.0046
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0045
465 Calmodulin CALM1 0.0045
6220 Aryl hydrocarbon receptor AHR 0.0045
4878 Glycoprotein hormones alpha chain CGA 0.0045
1052 Cytotoxic T-lymphocyte protein 4 CTLA4 0.0044
4871 Endo-beta-N-acetylglucosaminidase F3 endOF3 0.0044
1072 Granzyme B GZMB 0.0044
4877 Beta-mannanase man 0.0044
4852 Reticulon-4 receptor RTN4R 0.0044
4850 Beta-2-glycoprotein 1 APOH 0.0044
4880 Membrane cofactor protein CD46 0.0044
4856 CD209 antigen CD209 0.0044
442 Envelope glycoprotein gp41 0.0044
4859 Envelope glycoprotein env 0.0044
4889 Ig epsilon chain C region IGHE 0.0044
4189 Alpha-galactosidase A GLA 0.0044
4869 Major capsid protein A430L 0.0044
757 Fusion glycoprotein F0 F 0.0044
4875 Fusion glycoprotein F0 F 0.0044
4721 Beta-1,4-mannanase manA 0.0044
1563 Platelet glycoprotein Ib alpha chain GP1BA 0.0044
1354 Beta-glucuronidase GUSB 0.0044
3352 Structural polyprotein Not Available 0.0044
3628 Structural polyprotein Not Available 0.0044
4892 Structural polyprotein Not Available 0.0044
4845 ADAM 33 ADAM33 0.0044
4882 Dipeptidyl aminopeptidase-like protein 6 DPP6 0.0044
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0044
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0044
777 Tumor necrosis factor TNF 0.0044
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0043
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0042
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0042
2236 Casein kinase II subunit alpha CSNK2A1 0.0042
714 Glutathione reductase, mitochondrial GSR 0.0042
207 Glutathione synthetase GSS 0.0042
5269 Glutathione synthetase gshB 0.0042
6143 Solute carrier family 22 member 7 SLC22A7 0.0041
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0041
2251 Thymidylate kinase tmk 0.0041
2254 Thymidylate kinase DTYMK 0.0041
3522 Thymidylate kinase tmk 0.0041
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.004
103 Muscarinic acetylcholine receptor M1 CHRM1 0.004
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.004
432 D(4) dopamine receptor DRD4 0.004
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.004
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0039
833 Organic cation/carnitine transporter 1 SLC22A4 0.0039
1184 Interferon beta IFNB1 0.0039
793 T-cell surface antigen CD2 CD2 0.0039
6858 Inactive carboxylesterase 4 CES1P1 0.0039
4857 Zinc-alpha-2-glycoprotein AZGP1 0.0039
1379 Interleukin-12 subunit beta IL12B 0.0039
4861 Interleukin-6 receptor alpha chain IL6R 0.0039
119 Carcinoembryonic antigen-related cell adhesion molecule 1 CEACAM1 0.0039
4193 Atrial natriuretic peptide clearance receptor NPR3 0.0039
4890 Hemagglutinin HA 0.0039
6566 Hemagglutinin Not Available 0.0039
3837 Cytokine receptor common beta chain CSF2RB 0.0039
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0038
605 Fumarate reductase flavoprotein subunit frdA 0.0038
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0038
3673 Fumarate reductase flavoprotein subunit fccA 0.0038
4912 Fumarate reductase flavoprotein subunit ifcA 0.0038
6549 Fumarate reductase flavoprotein subunit frdA 0.0038
3822 Actin, alpha skeletal muscle ACTA1 0.0038
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0037
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0037
511 5-hydroxytryptamine 1F receptor HTR1F 0.0037
1836 Mitogen-activated protein kinase 10 MAPK10 0.0036
554 Low-density lipoprotein receptor LDLR 0.0036
3444 Cyanovirin-N Not Available 0.0036
2998 Sialic acid-binding Ig-like lectin 7 SIGLEC7 0.0036
1859 Prostatic acid phosphatase ACPP 0.0036
3258 Mannosyl-oligosaccharide alpha-1,2-mannosidase MSDC 0.0036
3140 Hemagglutinin-neuraminidase HN 0.0036
3609 Hemagglutinin-neuraminidase HN 0.0036
2297 Genome polyprotein Not Available 0.0036
2322 Genome polyprotein Not Available 0.0036
2694 Genome polyprotein Not Available 0.0036
2719 Genome polyprotein Not Available 0.0036
2860 Genome polyprotein Not Available 0.0036
2928 Genome polyprotein Not Available 0.0036
3160 Genome polyprotein Not Available 0.0036
3260 Genome polyprotein Not Available 0.0036
4783 Genome polyprotein Not Available 0.0036
5726 Genome polyprotein Not Available 0.0036
5779 Genome polyprotein Not Available 0.0036
5867 Genome polyprotein Not Available 0.0036
6253 Genome polyprotein Not Available 0.0036
6301 Genome polyprotein Not Available 0.0036
6380 Genome polyprotein Not Available 0.0036
6381 Genome polyprotein Not Available 0.0036
6437 Genome polyprotein Not Available 0.0036
6520 Genome polyprotein Not Available 0.0036
6521 Genome polyprotein Not Available 0.0036
6652 Genome polyprotein Not Available 0.0036
6734 Genome polyprotein Not Available 0.0036
6735 Genome polyprotein Not Available 0.0036
6736 Genome polyprotein Not Available 0.0036
6737 Genome polyprotein Not Available 0.0036
6738 Genome polyprotein Not Available 0.0036
6739 Genome polyprotein Not Available 0.0036
6744 Genome polyprotein Not Available 0.0036
6748 Genome polyprotein Not Available 0.0036
6894 Genome polyprotein Not Available 0.0036
6898 Genome polyprotein Not Available 0.0036
1721 Glycogen synthase kinase-3 beta GSK3B 0.0035
5998 Toll-like receptor 8 TLR8 0.0035
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0035
273 Apoptosis regulator Bcl-2 BCL2 0.0034
18 High affinity immunoglobulin epsilon receptor subunit alpha FCER1A 0.0034
1757 Myeloperoxidase MPO 0.0034
565 Extracellular calcium-sensing receptor CASR 0.0034
852 Heparin cofactor 2 SERPIND1 0.0034
712 Tubulin alpha chain TUB1 0.0034
161 Tubulin beta chain TUBB 0.0034
312 Tubulin beta chain TUB2 0.0034
6014 Cytochrome P450 2A13 CYP2A13 0.0034
3947 Xanthine dehydrogenase/oxidase XDH 0.0034
4666 Fucose-binding lectin PA-IIL lecB 0.0034
4787 Envelope glycoprotein gp160 env 0.0034
4820 Envelope glycoprotein gp160 env 0.0034
5727 Envelope glycoprotein gp160 env 0.0034
2372 Bifunctional tail protein 9 0.0034
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0033
4122 Histone deacetylase 2 HDAC2 0.0033
468 Cytochrome P450 4A11 CYP4A11 0.0033
613 Atrial natriuretic peptide receptor A NPR1 0.0033
6147 Solute carrier family 22 member 3 SLC22A3 0.0032
2577 Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase MAN1B1 0.0032
4604 Liver carboxylesterase 1 CES1 0.0032
6142 Solute carrier family 22 member 8 SLC22A8 0.0032
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0031
2164 Multidrug resistance-associated protein 4 ABCC4 0.0031
3480 Mannan endo-1,4-beta-mannosidase manA 0.0031
64 Neuraminidase NA 0.0031
641 Neuraminidase NA 0.0031
2676 Neuraminidase NA 0.0031
3026 Neuraminidase NA 0.0031
3519 Neuraminidase NA 0.0031
6007 Neuraminidase NA 0.0031
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0031
818 50S ribosomal protein L10 rplJ 0.003
595 Fibrinogen alpha chain FGA 0.003
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.003
259 Microsomal triglyceride transfer protein large subunit MTTP 0.003
1439 Lactotransferrin LTF 0.003
173 Toll-like receptor 7 TLR7 0.003
117 Sterol O-acyltransferase 1 SOAT1 0.003
1782 Neutrophil gelatinase-associated lipocalin LCN2 0.003
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0029
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0029
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0029
2430 Chondroitinase B cslB 0.0029
992 Protein tyrosine kinase 2 beta PTK2B 0.0028
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0028
776 Bile salt export pump ABCB11 0.0028
163 D(1B) dopamine receptor DRD5 0.0028
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0028
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0028
6307 Ig gamma-2 chain C region IGHG2 0.0028
2581 Chondroitinase AC cslA 0.0028
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0028
6044 Serum paraoxonase/lactonase 3 PON3 0.0028
436 5-hydroxytryptamine 2B receptor HTR2B 0.0028
6847 Lactase-phlorizin hydrolase LCT 0.0028
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0027
6500 Phospholipase A2 PLA2G1B 0.0027
309 Antithrombin-III SERPINC1 0.0027
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.0026
790 DNA polymerase subunit alpha B POLA2 0.0026
2207 Rhodopsin RHO 0.0026
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0025
94 5-hydroxytryptamine 4 receptor HTR4 0.0025
5880 Thrombopoietin receptor MPL 0.0025
3814 Complement C1r subcomponent C1R 0.0025
1517 Beta-3 adrenergic receptor ADRB3 0.0024
6070 Nischarin NISCH 0.0024
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0023
4785 Ig gamma-1 chain C region IGHG1 0.0023
550 Amiloride-sensitive sodium channel subunit delta SCNN1D 0.0023
27 Amiloride-sensitive sodium channel subunit beta SCNN1B 0.0023
552 Amiloride-sensitive sodium channel subunit gamma SCNN1G 0.0023
213 Amiloride-sensitive sodium channel subunit alpha SCNN1A 0.0023
76 Nitric-oxide synthase, brain NOS1 0.0023
3957 Adenosine deaminase ADA 0.0023
6148 Multidrug resistance-associated protein 7 ABCC10 0.0023
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0023
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0023
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0022
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0022
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0022
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0022
26 Vascular endothelial growth factor receptor 3 FLT4 0.0022
731 HIV-1 protease HIV-1 protease 0.0021
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.0021
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0021
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0021
260 Cytochrome P450 51 ERG11 0.0021
761 Cytochrome P450 51 ERG11 0.0021
3163 Cytochrome P450 51 cyp51 0.0021
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0021
32 Vascular endothelial growth factor receptor 1 FLT1 0.0021
869 Estrogen receptor beta ESR2 0.0021
871 Glucocorticoid receptor NR3C1 0.0021
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.002
952 Dipeptidyl peptidase 4 DPP4 0.002
6020 Aldehyde oxidase AOX1 0.002
1820 Beta-nerve growth factor NGF 0.002
4228 Keratin, type II cytoskeletal 7 KRT7 0.002
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.002
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.002
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.002
228 Beta platelet-derived growth factor receptor PDGFRB 0.0019
716 5-hydroxytryptamine 7 receptor HTR7 0.0019
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0019
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0019
124 Histamine H2 receptor HRH2 0.0019
284 DNA-directed RNA polymerase beta chain rpoB 0.0019
5773 DNA-directed RNA polymerase beta chain rpoB 0.0019
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0019
512 DNA-directed RNA polymerase alpha chain rpoA 0.0019
5772 DNA-directed RNA polymerase alpha chain rpoA 0.0019
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0019
122 P2Y purinoceptor 12 P2RY12 0.0018
33 Cystine/glutamate transporter SLC7A11 0.0018
6766 O-GlcNAcase BT_4395 BT_4395 0.0018
504 Mast/stem cell growth factor receptor KIT 0.0018
1256 5-hydroxytryptamine 6 receptor HTR6 0.0017
1648 Elastin ELN 0.0017
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0017
275 Arachidonate 5-lipoxygenase ALOX5 0.0017
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0017
1656 CYP2B protein CYP2B 0.0017
407 Vascular endothelial growth factor receptor 2 KDR 0.0017
1830 5'-nucleotidase NT5E 0.0016
390 Adenosine A3 receptor ADORA3 0.0016
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0016
1010 Cytochrome P450 51A1 CYP51A1 0.0016
373 Transthyretin TTR 0.0016
474 Acetylcholinesterase ACHE 0.0016
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0016
427 Substance-P receptor TACR1 0.0016
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0016
921 Glutamate receptor 2 GRIA2 0.0015
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0015
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0015
6031 Cytochrome P450 3A43 CYP3A43 0.0015
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0015
70 Type-1 angiotensin II receptor AGTR1 0.0015
2499 Tubulin beta-2C chain TUBB2C 0.0015
6432 Transporter snf 0.0015
6102 Arylamine N-acetyltransferase 2 NAT2 0.0014
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0014
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0014
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0014
2091 Endoplasmin HSP90B1 0.0014
6859 Protein S100-A4 S100A4 0.0014
904 Glutathione S-transferase P GSTP1 0.0014
2449 Tubulin alpha-3 chain TUBA1A 0.0014
847 Mu-type opioid receptor OPRM1 0.0014
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0013
543 Penicillin-binding protein 1B mrcB 0.0013
6186 Penicillin-binding protein 1B ponB 0.0013
6822 Penicillin-binding protein 1b pbp1b 0.0013
6844 Penicillin-binding protein 1b pbp1b 0.0013
380 Cytochrome P450 17A1 CYP17A1 0.0013
844 Epidermal growth factor receptor EGFR 0.0013
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0013
756 Sex hormone-binding globulin SHBG 0.0013
645 Penicillin-binding protein 1A mrcA 0.0013
5805 Penicillin-binding protein 1A ponA 0.0013
6185 Penicillin-binding protein 1A mrcA 0.0013
6799 Penicillin-binding protein 1A pbpA 0.0013
159 Penicillin-binding protein 2B penA 0.0013
6121 Penicillin-binding protein 2B penA 0.0013
696 Kappa-type opioid receptor OPRK1 0.0013
5626 Nucleoside diphosphate kinase B NME2 0.0013
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0013
1024 Solute carrier family 22 member 11 SLC22A11 0.0013
6146 High affinity copper uptake protein 1 SLC31A1 0.0012
4311 tRNA TRDMT1 0.0012
4325 tRNA trmD 0.0012
4328 tRNA trmD 0.0012
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0012
518 Peroxidase/catalase T katG 0.0012
1629 Transcription factor AP-1 JUN 0.0012
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0012
482 Glycine receptor subunit alpha-1 GLRA1 0.0011
828 Phenylalanine-4-hydroxylase PAH 0.0011
3109 Phenylalanine-4-hydroxylase phhA 0.0011
4238 50S ribosomal protein L4 rplD 0.0011
5578 50S ribosomal protein L4 rplD 0.0011
6173 50S ribosomal protein L4 rplD 0.0011
6219 50S ribosomal protein L4 rplD 0.0011
6043 Putative G-protein coupled receptor 44 GPR44 0.0011
563 Thyroid peroxidase TPO 0.0011
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0011
467 Delta-type opioid receptor OPRD1 0.0011
950 Alpha platelet-derived growth factor receptor PDGFRA 0.001
634 Squalene monooxygenase SQLE 0.001
7196 Squalene monooxygenase ERG1 0.001
239 Coagulation factor X F10 0.001
4237 50S ribosomal protein L22 rplV 0.001
6136 Multidrug resistance-associated protein 5 ABCC5 0.001
1714 Mitogen-activated protein kinase 3 MAPK3 0.001
564 Cellular retinoic acid-binding protein 1 CRABP1 0.001
5294 Nucleoside diphosphate kinase A NME1 0.001
908 Glutathione S-transferase theta-1 GSTT1 0.001
1192 Sulfotransferase 1A1 SULT1A1 0.001
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.001
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.001
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.001
859 Cellular retinoic acid-binding protein 2 CRABP2 0.001
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.001
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.001
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.001
823 Fibroblast growth factor receptor 2 FGFR2 0.001
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.001
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.001
6137 Multidrug resistance-associated protein 6 ABCC6 0.0009
6182 Cytochrome P450 2J2 CYP2J2 0.0009
780 Retinoic acid receptor RXR-gamma RXRG 0.0009
229 Retinoic acid receptor beta RARB 0.0009
730 Retinoic acid receptor alpha RARA 0.0009
3917 Methylenetetrahydrofolate reductase MTHFR 0.0009
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0009
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0009
365 Dihydrofolate reductase DHFR 0.0009
2381 Dihydrofolate reductase DFR1 0.0009
2833 Dihydrofolate reductase Not Available 0.0009
2931 Dihydrofolate reductase folA 0.0009
3544 Dihydrofolate reductase folA 0.0009
3682 Dihydrofolate reductase folA 0.0009
6642 Dihydrofolate reductase folA 0.0009
6756 Dihydrofolate reductase dfrA 0.0009
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0009
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0009
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0009
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0009
459 Retinoic acid receptor RXR-alpha RXRA 0.0008
528 5-hydroxytryptamine 1E receptor HTR1E 0.0008
88 Retinoic acid receptor RXR-beta RXRB 0.0008
3830 Calreticulin CALR 0.0008
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0008
162 Retinoic acid receptor gamma-1 RARG 0.0008
6167 Organic solute transporter subunit beta OSTB 0.0008
6166 Organic solute transporter subunit alpha OSTA 0.0008
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0008
146 Androgen receptor AR 0.0008
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0008
1618 High affinity nerve growth factor receptor NTRK1 0.0008
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0008
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0008
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0008
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0008
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0008
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0008
6034 Hydroxyindole O-methyltransferase ASMT 0.0008
6035 Nuclear receptor ROR-beta RORB 0.0008
6036 Eosinophil peroxidase EPX 0.0008
811 Translocator protein TSPO 0.0008
3856 Fibroblast growth factor receptor 3 FGFR3 0.0008
976 Platelet glycoprotein IX GP9 0.0008
1374 Natriuretic peptides B NPPB 0.0008
1827 Gap junction alpha-1 protein GJA1 0.0008
1908 Vascular cell adhesion protein 1 VCAM1 0.0008
400 Coagulation factor IX F9 0.0008
5461 Coagulation factor IX F9 0.0008
4103 Proteasome subunit beta type 2 PSMB2 0.0007
4102 Proteasome subunit beta type 5 PSMB5 0.0007
4101 Proteasome subunit beta type 1 PSMB1 0.0007
1063 Signal transducer and activator of transcription 5B STAT5B 0.0007
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0007
4226 Uridine phosphorylase 2 UPP2 0.0007
3810 Catechol O-methyltransferase COMT 0.0007
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0007
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0007
814 Ryanodine receptor 1 RYR1 0.0007
822 Aldose reductase AKR1B1 0.0007
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0007
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0007
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0007
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0007
4081 Vitamin K epoxide reductase complex subunit 1-like protein 1 VKORC1L1 0.0007
604 Vitamin K-dependent protein Z PROZ 0.0007
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0007
6228 Nuclear receptor coactivator 1 NCOA1 0.0007
6241 Nuclear receptor coactivator 2 NCOA2 0.0007
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0007
765 Indoleamine 2,3-dioxygenase IDO1 0.0007
251 Alcohol dehydrogenase 1A ADH1A 0.0007
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0007
4225 Uridine phosphorylase 1 UPP1 0.0007
705 Glutamate receptor 1 GRIA1 0.0007
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0007
6141 Sodium/bile acid cotransporter SLC10A1 0.0007
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0006
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0006
820 Glycine receptor subunit alpha-2 GLRA2 0.0006
268 Adenosine A2b receptor ADORA2B 0.0006
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0006
1245 Vitamin K-dependent protein S PROS1 0.0006
413 Amidophosphoribosyltransferase PPAT 0.0006
2515 Amidophosphoribosyltransferase purF 0.0006
3714 Amidophosphoribosyltransferase purF 0.0006
422 Vitamin K-dependent protein C PROC 0.0006
537 ATP synthase delta chain, mitochondrial ATP5D 0.0006
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0006
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0006
484 Tyrosine-protein kinase ABL2 ABL2 0.0006
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0006
444 Alcohol dehydrogenase 1B ADH1B 0.0006
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0006
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0006
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0006
183 Vascular endothelial growth factor A VEGFA 0.0006
6163 Copper-transporting ATPase 2 ATP7B 0.0006
6165 Copper-transporting ATPase 1 ATP7A 0.0006
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0006
448 Vitamin K-dependent gamma-carboxylase GGCX 0.0006
1864 RET proto-oncogene RET 0.0006
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0006
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0006
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0006
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0006
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0006
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0006
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0006
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0006
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0006
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0006
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0006
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0005
1275 Estrogen sulfotransferase SULT1E1 0.0005
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0005
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0005
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0005
153 Dopamine beta-hydroxylase DBH 0.0005
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0005
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0005
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0005
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0005
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0005
3639 Thymidine phosphorylase deoA 0.0005
3936 Thymidine phosphorylase TYMP 0.0005
760 Fibroblast growth factor 1 FGF1 0.0005
517 Alcohol dehydrogenase 1C ADH1C 0.0005
798 Osteocalcin BGLAP 0.0005
5934 Cytochrome P450 26A1 CYP26A1 0.0005
1050 Bile salt sulfotransferase SULT2A1 0.0005
751 Potassium channel subfamily K member 6 KCNK6 0.0005
1039 Histone deacetylase 9 HDAC9 0.0005
4120 NADPH--cytochrome P450 reductase POR 0.0005
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0005
1360 Sphingomyelin phosphodiesterase SMPD1 0.0005
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0005
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0005
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0005
369 Coagulation factor VII F7 0.0005
896 Glutathione S-transferase Mu 1 GSTM1 0.0005
3937 Fatty-acid amide hydrolase FAAH 0.0005
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0005
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0005
172 Potassium channel subfamily K member 1 KCNK1 0.0005
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0005
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0004
6149 Solute carrier family 22 member 10 SLC22A10 0.0004
165 FL cytokine receptor FLT3 0.0004
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0004
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0004
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0004
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0004
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0004
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0004
24 Thymidylate synthase TMP1 0.0004
359 Thymidylate synthase TYMS 0.0004
2626 Thymidylate synthase thyA 0.0004
2729 Thymidylate synthase thyA 0.0004
5352 Thymidylate synthase THYA 0.0004
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0004
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0004
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0004
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0004
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0004
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0004
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0004
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0004
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0004
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0004
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0004
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0004
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0004
737 Mineralocorticoid receptor NR3C2 0.0004
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0004
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0004
295 Carbonic anhydrase 1 CA1 0.0004
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0004
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0004
614 Progesterone receptor PGR 0.0003
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0003
6085 Fatty acid-binding protein, intestinal FABP2 0.0003
2981 Phospholipase A2, membrane associated PLA2G2A 0.0003
164 Histamine H4 receptor HRH4 0.0003
54 Prothrombin F2 0.0003
738 Monocarboxylate transporter 1 SLC16A1 0.0003
7 Nitric oxide synthase, inducible NOS2 0.0003
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0003
291 Nitric-oxide synthase, endothelial NOS3 0.0003
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0002
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0002
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