DT-Web

DB00678 - Losartan


Identification
Name Losartan
Accession Number DB00678 (APRD00052)
Type small molecule
Description Losartan is an angiotensin-receptor blocker (ARB) that may be used alone or with other agents to treat hypertension. Losartan and its longer acting metabolite, E-3174, lower blood pressure by antagonizing the renin-angiotensin-aldosterone system (RAAS); they compete with angiotensin II for binding to the type-1 angiotensin II receptor (AT1) subtype and prevents the blood pressure increasing effects of angiotensin II. Unlike angiotensin-converting enzyme (ACE) inhibitors, ARBs do not have the adverse effect of dry cough. Losartan may be used to treat hypertension, isolated systolic hypertension, left ventricular hypertrophy and diabetic nephropathy. It may also be used as an alternative agent for the treatment of systolic dysfunction, myocardial infarction, coronary artery disease, and heart failure.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 422.911
Groups approved
Monoisotopic Weight 422.162187095
Pharmacology
Indication May be used as a first line agent to treat uncomplicated hypertension, isolated systolic hypertension and left ventricular hypertrophy. May be used as a first line agent to delay progression of diabetic nephropathy. Losartan may be also used as a second line agent in the treatment of congestive heart failure, systolic dysfunction, myocardial infarction and coronary artery disease in those intolerant of ACE inhibitors.
Mechanism of action Losartan competitively inhibits the binding of angiotensin II to AT1 in many tissues including vascular smooth muscle and the adrenal glands. Losartan is metabolized to its active metabolite, E-3174, which is 10 to 40 times more potent than losartan and acts as a non-competitive AT1 antagonist. Inhibition of angiotensin II binding to AT1 inhibits its AT1-mediated vasoconstrictive and aldosterone-secreting effects and results in decreased vascular resistance and blood pressure. Losartan is 1,000 times more selective for AT1 than AT2. Inhibition of aldosterone secretion may increase sodium and water excretion while decreasing potassium excretion. Losartan is effective for reducing blood pressure and may be used to treat essential hypertension, left ventricular hypertrophy and diabetic nephropathy.
Absorption Losartan is well absorbed and undergoes substantial first-pass metabolism; the systemic bioavailability of losartan is approximately 33%. Mean peak concentrations of losartan and its active metabolite are reached in 1 hour and in 3-4 hours, respectively. While maximum plasma concentrations of losartan and its active metabolite are approximately equal, the AUC of the metabolite is about 4 times as great as that of losartan. When given with a meal, absorption is slows down and Cmax decreases.
Protein binding 99.7% protein bound, primarily to albumin
Biotransformation Hepatic. Losartan is metabolized to a 5-carboxylic acid derivative (E-3174) via an aldehyde intermediate (E-3179) primarily by cytochrome P450 (CYP) 2C9 and CYP3A4. E-3174 is an active metabolite with 10- to 40-fold higher potency than its parent compound, losartan. Approxiamtely 14% of losartan is converted to E-3174; however, the AUC of E-3174 was found to be 4- to 8-fold higher than losartan and E-3174 is considered the main contributor to the pharmacologic effects of this medication.
Route of elimination Following oral administration of losartan, 35% of the dose is recovered in the urine and about 60% in the feces. Following an intravenous dose, 45% is recovered in the urine and 50% in the feces.
Toxicity Hypotension and tachycardia; Bradycardia could occur from parasympathetic (vagal) stimulation, LD50= 1000 mg/kg (orally in rat)
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Amiloride Increased risk of hyperkalemia
Drospirenone Increased risk of hyperkalemia
Indomethacin Indomethacin decreases the effect of losartan
Insulin Lispro Concomitant therapy with angiotensin II receptor blockers may increase the blood-glucose-lowering effect of insulin lispro and thus the chance of hypoglycemia should be monitored closely.
Lithium Losartan increases serum levels of lithium
Potassium Increased risk of hyperkalemia
Quinupristin This combination presents an increased risk of toxicity
Rifampin Rifampin decreases the effect of losartan
Spironolactone Increased risk of hyperkalemia
Tobramycin Increased risk of nephrotoxicity
Tolbutamide Tolbutamide, a strong CYP2C9 inhibitor, may decrease the metabolism and clearance of Losartan. Consider alternate therapy or monitor for changes in Losartan therapeutic and adverse effects if Tolbutamide is initiated, discontinued or dose changed.
Trandolapril The angiotensin II receptor blocker, Losartan, may increase the adverse effects of Trandolapril.
Treprostinil Additive hypotensive effect. Monitor antihypertensive therapy during concomitant use.
Tretinoin The moderate CYP2C8 inhibitor, Losartan, may decrease the metabolism and clearance of oral Tretinoin. Monitor for changes in Tretinoin effectiveness and adverse/toxic effects if Losartan is initiated, discontinued to dose changed.
Triamterene Increased risk of hyperkalemia
Food Interactions
  • Take without regard to meals. Take at same time each day. Food delays absorption, but does not affect the extent of absorption.

Targets


Type-1 angiotensin II receptor
Name Type-1 angiotensin II receptor
Gene Name AGTR1
Pharmacological action yes
Actions antagonist
References
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
  • Sardo MA, Castaldo M, Cinquegrani M, Bonaiuto M, Fontana L, Campo S, Campo GM, Altavilla D, Saitta A: Effects of AT1 receptor antagonist losartan on sICAM-1 and TNF-alpha levels in uncomplicated hypertensive patients. Angiology. 2004 Mar-Apr;55(2):195-203. - Pubmed
  • Dickstein K, Timmermans P, Segal R: Losartan: a selective angiotensin II type 1 (AT1) receptor antagonist for the treatment of heart failure. Expert Opin Investig Drugs. 1998 Nov;7(11):1897-914. - Pubmed
  • Anand-Srivastava MB, Palaparti A: Angiotensin-II-induced enhanced expression of Gi proteins is attenuated by losartan in A10 vascular smooth muscle cells: role of AT1 receptors. Can J Physiol Pharmacol. 2003 Feb;81(2):150-8. - Pubmed
  • Rocha I, Bras-Rosario L, Amparo-Barros M, Silva-Carvalho L: Angiotensin AT1 receptor antagonist losartan and the defence reaction in the anaesthetised rat. Effect on the carotid chemoreflex. Exp Physiol. 2003 May;88(3):309-14. - Pubmed
  • Guan J, Cheng DY, Chen XJ, Zhang Y, Wang H, Su QL: [The effects of losartan on pulmonary arterial collagen and AT1 in chronic hypoxic rats] Sichuan Da Xue Xue Bao Yi Xue Ban. 2004 Nov;35(6):774-7. - Pubmed
DTHybrid score 0.7852

Enzymes


Cytochrome P450 2C9
Name Cytochrome P450 2C9
Gene Name CYP2C9
Actions substrate,inhibitor
References
  • Song JC, White CM: Pharmacologic, pharmacokinetic, and therapeutic differences among angiotensin II receptor antagonists. Pharmacotherapy. 2000 Feb;20(2):130-9. - Pubmed
  • Sica DA, Gehr TW, Ghosh S: Clinical pharmacokinetics of losartan. Clin Pharmacokinet. 2005;44(8):797-814. - Pubmed
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
  • Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
  • Yasar U, Forslund-Bergengren C, Tybring G, Dorado P, Llerena A, Sjoqvist F, Eliasson E, Dahl ML: Pharmacokinetics of losartan and its metabolite E-3174 in relation to the CYP2C9 genotype. Clin Pharmacol Ther. 2002 Jan;71(1):89-98. - Pubmed
DTHybrid score 0.7364
Cytochrome P450 3A4
Name Cytochrome P450 3A4
Gene Name CYP3A4
Actions substrate,inhibitor
References
  • Song JC, White CM: Pharmacologic, pharmacokinetic, and therapeutic differences among angiotensin II receptor antagonists. Pharmacotherapy. 2000 Feb;20(2):130-9. - Pubmed
  • Sica DA, Gehr TW, Ghosh S: Clinical pharmacokinetics of losartan. Clin Pharmacokinet. 2005;44(8):797-814. - Pubmed
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.8784
Cytochrome P450 3A5
Name Cytochrome P450 3A5
Gene Name CYP3A5
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.4636
Cytochrome P450 2C8
Name Cytochrome P450 2C8
Gene Name CYP2C8
Actions substrate,inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.5553
Cytochrome P450 2C19
Name Cytochrome P450 2C19
Gene Name CYP2C19
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.5717
Cytochrome P450 1A2
Name Cytochrome P450 1A2
Gene Name CYP1A2
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.554
UDP-glucuronosyltransferase 1-1
Name UDP-glucuronosyltransferase 1-1
Gene Name UGT1A1
Actions substrate
References
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
DTHybrid score 0.3877
UDP-glucuronosyltransferase 1-3
Name UDP-glucuronosyltransferase 1-3
Gene Name UGT1A3
Actions substrate
References
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
DTHybrid score 0.3867
UDP-glucuronosyltransferase 1-10
Name UDP-glucuronosyltransferase 1-10
Gene Name UGT1A10
Actions substrate
References
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
DTHybrid score 0.2206
UDP-glucuronosyltransferase 2B7
Name UDP-glucuronosyltransferase 2B7
Gene Name UGT2B7
Actions substrate
References
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
DTHybrid score 0.3869
UDP-glucuronosyltransferase 2B17
Name UDP-glucuronosyltransferase 2B17
Gene Name UGT2B17
Actions substrate
References
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
DTHybrid score 0.1919

Transporters


Multidrug resistance protein 1
Name Multidrug resistance protein 1
Gene Name ABCB1
Actions substrate,inhibitor
References
  • Takara K, Kakumoto M, Tanigawara Y, Funakoshi J, Sakaeda T, Okumura K: Interaction of digoxin with antihypertensive drugs via MDR1. Life Sci. 2002 Feb 15;70(13):1491-500. - Pubmed
  • Borgnia MJ, Eytan GD, Assaraf YG: Competition of hydrophobic peptides, cytotoxic drugs, and chemosensitizers on a common P-glycoprotein pharmacophore as revealed by its ATPase activity. J Biol Chem. 1996 Feb 9;271(6):3163-71. - Pubmed
  • Soldner A, Benet LZ, Mutschler E, Christians U: Active transport of the angiotensin-II antagonist losartan and its main metabolite EXP 3174 across MDCK-MDR1 and caco-2 cell monolayers. Br J Pharmacol. 2000 Mar;129(6):1235-43. - Pubmed
DTHybrid score 0.6182
Solute carrier family 22 member 6
Name Solute carrier family 22 member 6
Gene Name SLC22A6
Actions inhibitor
References
  • Race JE, Grassl SM, Williams WJ, Holtzman EJ: Molecular cloning and characterization of two novel human renal organic anion transporters (hOAT1 and hOAT3). Biochem Biophys Res Commun. 1999 Feb 16;255(2):508-14. - Pubmed
DTHybrid score 0.4052
Solute carrier family 22 member 12
Name Solute carrier family 22 member 12
Gene Name Not Available
Actions inhibitor
References
  • Lipkowitz MS: Regulation of uric acid excretion by the kidney. Curr Rheumatol Rep. 2012 Apr;14(2):179-88. doi: 10.1007/s11926-012-0240-z. - Pubmed
  • Burnier M, Roch-Ramel F, Brunner HR: Renal effects of angiotensin II receptor blockade in normotensive subjects. Kidney Int. 1996 Jun;49(6):1787-90. - Pubmed
DTHybrid score Not Available
Solute carrier family 2, facilitated glucose transporter member 9
Name Solute carrier family 2, facilitated glucose transporter member 9
Gene Name Not Available
Actions inhibitor
References
  • Lipkowitz MS: Regulation of uric acid excretion by the kidney. Curr Rheumatol Rep. 2012 Apr;14(2):179-88. doi: 10.1007/s11926-012-0240-z. - Pubmed
  • Burnier M, Roch-Ramel F, Brunner HR: Renal effects of angiotensin II receptor blockade in normotensive subjects. Kidney Int. 1996 Jun;49(6):1787-90. - Pubmed
DTHybrid score Not Available

Carriers


Multidrug resistance protein 1
Name Multidrug resistance protein 1
Gene Name ABCB1
Actions
References Not Available
DTHybrid score 0.6182
Solute carrier family 22 member 6
Name Solute carrier family 22 member 6
Gene Name SLC22A6
Actions
References Not Available
DTHybrid score 0.4052
Solute carrier family 22 member 12
Name Solute carrier family 22 member 12
Gene Name Not Available
Actions
References Not Available
DTHybrid score Not Available
Solute carrier family 2, facilitated glucose transporter member 9
Name Solute carrier family 2, facilitated glucose transporter member 9
Gene Name Not Available
Actions
References Not Available
DTHybrid score Not Available

Predictions


Id Partner name Gene Name Score
4119 Cytochrome P450 2D6 CYP2D6 0.4002
6107 Cytochrome P450 3A7 CYP3A7 0.2644
20 Prostaglandin G/H synthase 1 PTGS1 0.2455
6030 Cytochrome P450 2B6 CYP2B6 0.2445
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.2085
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.1929
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.1889
6013 Cytochrome P450 2E1 CYP2E1 0.1886
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.1788
6024 Cytochrome P450 1A1 CYP1A1 0.1711
290 Prostaglandin G/H synthase 2 PTGS2 0.164
5718 Cytochrome P450 2A6 CYP2A6 0.1438
6142 Solute carrier family 22 member 8 SLC22A8 0.1215
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.119
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.1184
862 Multidrug resistance-associated protein 1 ABCC1 0.1035
1181 Alpha-1-acid glycoprotein 1 ORM1 0.099
6106 Cytochrome P450 2C18 CYP2C18 0.0899
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0871
1024 Solute carrier family 22 member 11 SLC22A11 0.085
6143 Solute carrier family 22 member 7 SLC22A7 0.0829
2164 Multidrug resistance-associated protein 4 ABCC4 0.0814
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0772
492 Histamine H1 receptor HRH1 0.0719
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0716
6145 Solute carrier family 22 member 1 SLC22A1 0.0683
5852 Type-2 angiotensin II receptor AGTR2 0.0651
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0636
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0624
3811 Cytochrome P450 19A1 CYP19A1 0.0622
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0618
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0618
776 Bile salt export pump ABCB11 0.0606
824 Sodium-dependent serotonin transporter SLC6A4 0.0594
502 5-hydroxytryptamine 2A receptor HTR2A 0.0579
118 Organic cation/carnitine transporter 2 SLC22A5 0.0563
1898 Cytochrome P450 1B1 CYP1B1 0.0556
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0555
847 Mu-type opioid receptor OPRM1 0.0552
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0539
6144 Solute carrier family 22 member 2 SLC22A2 0.0532
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0532
556 Alpha-1A adrenergic receptor ADRA1A 0.0513
467 Delta-type opioid receptor OPRD1 0.0509
696 Kappa-type opioid receptor OPRK1 0.0501
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.05
831 D(2) dopamine receptor DRD2 0.0488
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0487
4604 Liver carboxylesterase 1 CES1 0.0453
817 DNA topoisomerase 2-alpha TOP2A 0.0441
136 Estrogen receptor ESR1 0.044
871 Glucocorticoid receptor NR3C1 0.0422
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0411
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0404
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0397
6102 Arylamine N-acetyltransferase 2 NAT2 0.0394
632 Alpha-1B adrenergic receptor ADRA1B 0.0392
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0392
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.039
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0388
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0381
320 5-hydroxytryptamine 1A receptor HTR1A 0.0372
766 Beta-2 adrenergic receptor ADRB2 0.0371
891 Dihydropteroate synthase folP 0.037
5359 Dihydropteroate synthase folP 0.037
7175 Dihydropteroate synthase sulI 0.037
590 5-hydroxytryptamine 2C receptor HTR2C 0.0369
23 D(1A) dopamine receptor DRD1 0.0366
459 Retinoic acid receptor RXR-alpha RXRA 0.0362
146 Androgen receptor AR 0.0361
5880 Thrombopoietin receptor MPL 0.0361
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.036
617 Muscarinic acetylcholine receptor M2 CHRM2 0.036
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0359
318 Alpha-2A adrenergic receptor ADRA2A 0.0359
731 HIV-1 protease HIV-1 protease 0.0352
6031 Cytochrome P450 3A43 CYP3A43 0.0347
404 DNA gyrase subunit A gyrA 0.0341
6224 DNA gyrase subunit A gyrA 0.0341
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0339
6141 Sodium/bile acid cotransporter SLC10A1 0.0335
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0332
36 Insulin receptor INSR 0.0325
3941 Amine oxidase [flavin-containing] A MAOA 0.0322
260 Cytochrome P450 51 ERG11 0.0316
761 Cytochrome P450 51 ERG11 0.0316
3163 Cytochrome P450 51 cyp51 0.0316
6136 Multidrug resistance-associated protein 5 ABCC5 0.0313
341 5-hydroxytryptamine 3 receptor HTR3A 0.0311
738 Monocarboxylate transporter 1 SLC16A1 0.0306
1629 Transcription factor AP-1 JUN 0.0296
789 Alpha-1D adrenergic receptor ADRA1D 0.0286
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0285
504 Mast/stem cell growth factor receptor KIT 0.0283
6147 Solute carrier family 22 member 3 SLC22A3 0.0282
26 Vascular endothelial growth factor receptor 3 FLT4 0.0275
713 Sodium-dependent dopamine transporter SLC6A3 0.0274
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0273
844 Epidermal growth factor receptor EGFR 0.0272
811 Translocator protein TSPO 0.0272
274 Muscarinic acetylcholine receptor M5 CHRM5 0.027
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.027
477 DNA topoisomerase 4 subunit A parC 0.0269
886 DNA topoisomerase 4 subunit A parC 0.0269
6226 DNA topoisomerase 4 subunit A parC 0.0269
6148 Multidrug resistance-associated protein 7 ABCC10 0.0266
6026 Alcohol dehydrogenase 6 ADH6 0.0266
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0266
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0266
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0265
122 P2Y purinoceptor 12 P2RY12 0.0265
6182 Cytochrome P450 2J2 CYP2J2 0.0264
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0263
32 Vascular endothelial growth factor receptor 1 FLT1 0.0262
468 Cytochrome P450 4A11 CYP4A11 0.0262
193 Beta-1 adrenergic receptor ADRB1 0.0262
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.026
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0253
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0252
407 Vascular endothelial growth factor receptor 2 KDR 0.0251
3923 Cholinesterase BCHE 0.0249
885 5-hydroxytryptamine 1B receptor HTR1B 0.0247
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0246
723 Cytosolic phospholipase A2 PLA2G4A 0.0246
1192 Sulfotransferase 1A1 SULT1A1 0.0245
6137 Multidrug resistance-associated protein 6 ABCC6 0.0242
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0242
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.024
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0238
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0238
833 Organic cation/carnitine transporter 1 SLC22A4 0.0236
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0235
267 Plasminogen activator inhibitor 1 SERPINE1 0.0235
6085 Fatty acid-binding protein, intestinal FABP2 0.0232
592 Carbonic anhydrase 4 CA4 0.0231
465 Calmodulin CALM1 0.023
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0229
6220 Aryl hydrocarbon receptor AHR 0.0228
3939 Amine oxidase [flavin-containing] B MAOB 0.0226
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0225
756 Sex hormone-binding globulin SHBG 0.0224
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0224
295 Carbonic anhydrase 1 CA1 0.0223
638 D(3) dopamine receptor DRD3 0.022
373 Transthyretin TTR 0.022
725 5-hydroxytryptamine 1D receptor HTR1D 0.0219
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0217
117 Sterol O-acyltransferase 1 SOAT1 0.0213
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0213
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0212
614 Progesterone receptor PGR 0.0212
6221 Steroid hormone receptor ERR1 ESRRA 0.0212
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0211
1039 Histone deacetylase 9 HDAC9 0.021
3810 Catechol O-methyltransferase COMT 0.021
633 Penicillin-binding proteins 1A/1B pbpA 0.0208
228 Beta platelet-derived growth factor receptor PDGFRB 0.0203
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0203
629 Alpha-2B adrenergic receptor ADRA2B 0.0202
1050 Bile salt sulfotransferase SULT2A1 0.02
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.02
3809 Estrogen-related receptor gamma ESRRG 0.0194
357 Carbonic anhydrase 2 CA2 0.0192
1275 Estrogen sulfotransferase SULT1E1 0.019
1760 Aminopeptidase N ANPEP 0.0187
6843 Aminopeptidase N pepN 0.0187
777 Tumor necrosis factor TNF 0.0181
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.018
1630 Integrin beta-2 ITGB2 0.018
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.018
4122 Histone deacetylase 2 HDAC2 0.0179
273 Apoptosis regulator Bcl-2 BCL2 0.0179
645 Penicillin-binding protein 1A mrcA 0.0178
5805 Penicillin-binding protein 1A ponA 0.0178
6185 Penicillin-binding protein 1A mrcA 0.0178
6799 Penicillin-binding protein 1A pbpA 0.0178
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0178
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0177
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0177
952 Dipeptidyl peptidase 4 DPP4 0.0175
869 Estrogen receptor beta ESR2 0.0174
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0174
6044 Serum paraoxonase/lactonase 3 PON3 0.0174
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0174
4164 Potassium voltage-gated channel subfamily KQT member 5 KCNQ5 0.0173
4163 Potassium voltage-gated channel subfamily KQT member 4 KCNQ4 0.0173
378 Alpha-2C adrenergic receptor ADRA2C 0.0171
3233 Bile acid receptor NR1H4 0.0171
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0171
380 Cytochrome P450 17A1 CYP17A1 0.0171
1389 Transforming growth factor beta-1 TGFB1 0.0169
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0167
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0167
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0167
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0167
275 Arachidonate 5-lipoxygenase ALOX5 0.0166
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0166
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0164
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0164
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0162
124 Histamine H2 receptor HRH2 0.016
319 Opioid receptor, sigma 1 OPRS1 0.016
6138 Multidrug resistance protein 3 ABCB4 0.016
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0158
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0155
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0155
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0154
558 Solute carrier family 12 member 1 SLC12A1 0.0153
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0152
2021 Thrombomodulin THBD 0.0151
543 Penicillin-binding protein 1B mrcB 0.0149
6186 Penicillin-binding protein 1B ponB 0.0149
6822 Penicillin-binding protein 1b pbp1b 0.0149
6844 Penicillin-binding protein 1b pbp1b 0.0149
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0149
6043 Putative G-protein coupled receptor 44 GPR44 0.0148
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0147
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0147
737 Mineralocorticoid receptor NR3C2 0.0146
6012 Tryptophan 2,3-dioxygenase TDO2 0.0145
436 5-hydroxytryptamine 2B receptor HTR2B 0.0144
818 50S ribosomal protein L10 rplJ 0.0144
588 Chromodomain-helicase-DNA-binding protein 1 CHD1 0.0144
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0144
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0144
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0144
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0144
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0144
6541 Peptostreptococcal albumin-binding protein pab 0.0142
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0142
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0142
3639 Thymidine phosphorylase deoA 0.0142
3936 Thymidine phosphorylase TYMP 0.0142
432 D(4) dopamine receptor DRD4 0.0141
1757 Myeloperoxidase MPO 0.0141
705 Glutamate receptor 1 GRIA1 0.014
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.014
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.014
232 Corticosteroid-binding globulin SERPINA6 0.0137
572 Integrin alpha-L ITGAL 0.0135
29 Tubulin beta-1 chain TUBB1 0.0134
183 Vascular endothelial growth factor A VEGFA 0.0134
6126 Carbonic anhydrase 7 CA7 0.0133
24 Thymidylate synthase TMP1 0.0132
359 Thymidylate synthase TYMS 0.0132
2626 Thymidylate synthase thyA 0.0132
2729 Thymidylate synthase thyA 0.0132
5352 Thymidylate synthase THYA 0.0132
6014 Cytochrome P450 2A13 CYP2A13 0.0132
4120 NADPH--cytochrome P450 reductase POR 0.0128
338 DNA polymerase UL30 0.0128
379 DNA polymerase UL54 0.0128
697 DNA polymerase ORF28 0.0128
2482 DNA polymerase 43 0.0128
4104 DNA polymerase BALF5 0.0128
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0127
54 Prothrombin F2 0.0127
2320 Thymidine kinase, cytosolic TK1 0.0126
1656 CYP2B protein CYP2B 0.0125
2981 Phospholipase A2, membrane associated PLA2G2A 0.0124
2183 Fatty acid-binding protein, adipocyte FABP4 0.0124
308 30S ribosomal protein S12 rpsL 0.0122
6704 30S ribosomal protein S12 rpsL 0.0122
571 Melatonin receptor type 1A MTNR1A 0.0122
362 Melatonin receptor type 1B MTNR1B 0.0122
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0121
427 Substance-P receptor TACR1 0.0121
161 Tubulin beta chain TUBB 0.0121
312 Tubulin beta chain TUB2 0.0121
4148 Serine/threonine-protein kinase mTOR MTOR 0.0121
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.012
244 Angiotensin-converting enzyme ACE 0.012
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0119
716 5-hydroxytryptamine 7 receptor HTR7 0.0118
365 Dihydrofolate reductase DHFR 0.0117
2381 Dihydrofolate reductase DFR1 0.0117
2833 Dihydrofolate reductase Not Available 0.0117
2931 Dihydrofolate reductase folA 0.0117
3544 Dihydrofolate reductase folA 0.0117
3682 Dihydrofolate reductase folA 0.0117
6642 Dihydrofolate reductase folA 0.0117
6756 Dihydrofolate reductase dfrA 0.0117
3932 Glutathione S-transferase A2 GSTA2 0.0117
1010 Cytochrome P450 51A1 CYP51A1 0.0115
16 Adenosine A1 receptor ADORA1 0.0114
2211 Fatty acid-binding protein, heart FABP3 0.0114
482 Glycine receptor subunit alpha-1 GLRA1 0.0114
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0112
1244 Low-density lipoprotein receptor-related protein 2 LRP2 0.0111
1 Peptidoglycan synthetase ftsI ftsI 0.011
4155 Peptidoglycan synthetase ftsI ftsI 0.011
4790 Glycosyltransferase GtfA gtfA 0.011
1178 Adenosine A2a receptor ADORA2A 0.011
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0107
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0107
94 5-hydroxytryptamine 4 receptor HTR4 0.0107
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0107
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0106
1353 DNA topoisomerase 1 TOP1 0.0106
3552 DNA topoisomerase 1 topA 0.0106
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0105
1618 High affinity nerve growth factor receptor NTRK1 0.0105
1792 Tissue-type plasminogen activator PLAT 0.0104
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0104
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0104
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0103
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0103
823 Fibroblast growth factor receptor 2 FGFR2 0.0103
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0102
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0101
6020 Aldehyde oxidase AOX1 0.01
474 Acetylcholinesterase ACHE 0.01
140 30S ribosomal protein S9 rpsI 0.01
6719 30S ribosomal protein S9 rpsI 0.01
6725 30S ribosomal protein S9 rpsI 0.01
4217 Telomerase reverse transcriptase TERT 0.0099
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0099
2539 Tubulin alpha-1 chain TUBA4A 0.0098
4116 Dihydropteroate synthetase Not Available 0.0097
6149 Solute carrier family 22 member 10 SLC22A10 0.0097
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0097
958 Insulin-like growth factor 1 receptor IGF1R 0.0097
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0097
5300 Antigen peptide transporter 1 TAP1 0.0096
49 Endothelin B receptor EDNRB 0.0096
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0095
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0095
566 Serotransferrin TF 0.0094
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0094
88 Retinoic acid receptor RXR-beta RXRB 0.0094
596 3-oxo-5-alpha-steroid 4-dehydrogenase 1 SRD5A1 0.0094
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0093
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0093
165 FL cytokine receptor FLT3 0.0093
5849 cAMP-dependent protein kinase type I-alpha regulatory subunit PRKAR1A 0.0092
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0092
239 Coagulation factor X F10 0.0091
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0091
3856 Fibroblast growth factor receptor 3 FGFR3 0.0091
578 Endothelin-1 receptor EDNRA 0.009
3947 Xanthine dehydrogenase/oxidase XDH 0.009
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.0088
537 ATP synthase delta chain, mitochondrial ATP5D 0.0088
284 DNA-directed RNA polymerase beta chain rpoB 0.0087
5773 DNA-directed RNA polymerase beta chain rpoB 0.0087
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0087
904 Glutathione S-transferase P GSTP1 0.0087
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0087
768 FK506-binding protein 1A FKBP1A 0.0087
4237 50S ribosomal protein L22 rplV 0.0087
5787 Angiopoietin-1 receptor TEK 0.0087
115 Penicillin-binding protein 2 mrdA 0.0086
6069 Penicillin-binding protein 2 mrdA 0.0086
6118 Penicillin-binding protein 2 penA 0.0086
6187 Penicillin-binding protein 2 pbpA 0.0086
6686 Penicillin-binding protein 2 pbp2 0.0086
6939 Penicillin-binding protein 2 mrdA 0.0086
7163 Penicillin-binding protein 2 pbpA 0.0086
163 D(1B) dopamine receptor DRD5 0.0085
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0085
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0085
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0085
921 Glutamate receptor 2 GRIA2 0.0084
642 3-oxo-5-alpha-steroid 4-dehydrogenase 2 SRD5A2 0.0083
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0083
1517 Beta-3 adrenergic receptor ADRB3 0.0082
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0082
2016 Dipeptidase 1 DPEP1 0.0082
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0081
1196 Complement decay-accelerating factor CD55 0.0081
22 30S ribosomal protein S4 rpsD 0.0081
6714 30S ribosomal protein S4 rpsD 0.0081
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.008
528 5-hydroxytryptamine 1E receptor HTR1E 0.008
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.008
3917 Methylenetetrahydrofolate reductase MTHFR 0.008
1256 5-hydroxytryptamine 6 receptor HTR6 0.008
6525 Group IID secretory phospholipase A2 PLA2G2D 0.008
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.008
780 Retinoic acid receptor RXR-gamma RXRG 0.008
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0079
5626 Nucleoside diphosphate kinase B NME2 0.0078
442 Envelope glycoprotein gp41 0.0078
4859 Envelope glycoprotein env 0.0078
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0078
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0077
4203 Histamine N-methyltransferase HNMT 0.0077
65 Matrix metalloproteinase-9 Not Available 0.0075
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0074
1541 Metalloproteinase mmp20 0.0074
6042 Prostaglandin reductase 2 PTGR2 0.0074
4238 50S ribosomal protein L4 rplD 0.0074
5578 50S ribosomal protein L4 rplD 0.0074
6173 50S ribosomal protein L4 rplD 0.0074
6219 50S ribosomal protein L4 rplD 0.0074
33 Cystine/glutamate transporter SLC7A11 0.0072
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0072
4192 DNA topoisomerase 2-beta TOP2B 0.0072
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0072
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0072
814 Ryanodine receptor 1 RYR1 0.0072
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0071
6174 50S ribosomal protein L32 rpmF 0.0071
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0071
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0071
2808 Chloramphenicol acetyltransferase 3 cat3 0.007
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.007
511 5-hydroxytryptamine 1F receptor HTR1F 0.007
2449 Tubulin alpha-3 chain TUBA1A 0.007
594 Thyroxine-binding globulin SERPINA7 0.007
1852 Microtubule-associated protein 2 MAP2 0.007
130 Prostacyclin synthase PTGIS 0.0069
162 Retinoic acid receptor gamma-1 RARG 0.0069
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0069
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0069
4311 tRNA TRDMT1 0.0068
4325 tRNA trmD 0.0068
4328 tRNA trmD 0.0068
2853 14 kDa fatty acid-binding protein Not Available 0.0068
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0068
68 Cannabinoid receptor 1 CNR1 0.0068
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0067
208 DNA-directed RNA polymerase beta' chain rpoC 0.0067
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0067
4773 Deoxycytidine kinase DCK 0.0066
527 Prostacyclin receptor PTGIR 0.0066
2499 Tubulin beta-2C chain TUBB2C 0.0065
936 Ephrin type-A receptor 2 EPHA2 0.0065
6033 High affinity interleukin-8 receptor A CXCR1 0.0065
758 Thyroid hormone receptor alpha THRA 0.0064
2417 Chloramphenicol acetyltransferase cat 0.0064
3278 Chloramphenicol acetyltransferase cat 0.0064
6432 Transporter snf 0.0064
2810 Dr hemagglutinin structural subunit draA 0.0064
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0063
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0063
1648 Elastin ELN 0.0063
3432 Multidrug-efflux transporter 1 regulator bmrR 0.0063
4476 Mannitol dehydrogenase mtlD 0.0063
5294 Nucleoside diphosphate kinase A NME1 0.0063
1119 Peroxiredoxin-5, mitochondrial PRDX5 0.0063
133 Dihydropterate synthase sulI 0.0063
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0062
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0062
153 Dopamine beta-hydroxylase DBH 0.0062
518 Peroxidase/catalase T katG 0.0061
6184 D-alanyl-D-alanine carboxypeptidase dacC dacC 0.0061
889 3-oxoacyl-[acyl-carrier-protein] synthase 1 fabB 0.0061
6860 3-oxoacyl-[acyl-carrier-protein] synthase 1 kasA 0.0061
1867 Major prion protein PRNP 0.006
469 Annexin A1 ANXA1 0.006
634 Squalene monooxygenase SQLE 0.006
7196 Squalene monooxygenase ERG1 0.006
4103 Proteasome subunit beta type 2 PSMB2 0.006
908 Glutathione S-transferase theta-1 GSTT1 0.006
4102 Proteasome subunit beta type 5 PSMB5 0.006
4101 Proteasome subunit beta type 1 PSMB1 0.006
185 Vasopressin V1a receptor AVPR1A 0.006
6103 Arylamine N-acetyltransferase 1 NAT1 0.0059
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0059
1714 Mitogen-activated protein kinase 3 MAPK3 0.0059
3426 Glutamine synthetase glnA 0.0059
3987 Glutamine synthetase GLUL 0.0059
3382 Glycolipid transfer protein GLTP 0.0058
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0058
322 Vasopressin V2 receptor AVPR2 0.0058
229 Retinoic acid receptor beta RARB 0.0058
346 Thyroid hormone receptor beta-1 THRB 0.0058
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0058
707 72 kDa type IV collagenase MMP2 0.0057
730 Retinoic acid receptor alpha RARA 0.0057
1313 Lactoylglutathione lyase GLO1 0.0057
3937 Fatty-acid amide hydrolase FAAH 0.0056
856 Vitamin D3 receptor VDR 0.0055
5798 Mitogen-activated protein kinase 11 MAPK11 0.0055
466 Solute carrier family 12 member 3 SLC12A3 0.0055
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0054
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0054
992 Protein tyrosine kinase 2 beta PTK2B 0.0054
976 Platelet glycoprotein IX GP9 0.0054
5934 Cytochrome P450 26A1 CYP26A1 0.0054
1483 Membrane copper amine oxidase AOC3 0.0054
4252 Penicillin-binding protein 5 dacA 0.0053
3086 Plasmepsin-2 Not Available 0.0053
2112 Toll-like receptor 9 TLR9 0.0053
5998 Toll-like receptor 8 TLR8 0.0053
6207 30S ribosomal protein S14 rpsN 0.0052
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0052
6209 30S ribosomal protein S19 rpsS 0.0052
6712 30S ribosomal protein S19 rpsS 0.0052
6726 30S ribosomal protein S19 rpsS 0.0052
159 Penicillin-binding protein 2B penA 0.0052
6121 Penicillin-binding protein 2B penA 0.0052
565 Extracellular calcium-sensing receptor CASR 0.0052
712 Tubulin alpha chain TUB1 0.0052
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0052
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0052
4752 Peroxisomal trans-2-enoyl-CoA reductase PECR 0.0052
2751 Holliday junction ATP-dependent DNA helicase ruvB ruvB 0.0052
4755 Holliday junction ATP-dependent DNA helicase ruvB ruvB 0.0052
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.0051
438 Taste receptor type 1 member 2 TAS1R2 0.0051
253 Sodium/potassium-transporting ATPase gamma chain FXYD2 0.0051
1992 Vitamin D-binding protein GC 0.0051
1525 Heparin-binding growth factor 2 FGF2 0.0051
2616 Ganglioside GM2 activator GM2A 0.0051
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.005
613 Atrial natriuretic peptide receptor A NPR1 0.005
6027 Alkaline phosphatase, tissue-nonspecific isozyme ALPL 0.005
6167 Organic solute transporter subunit beta OSTB 0.0049
6166 Organic solute transporter subunit alpha OSTA 0.0049
84 Nuclear receptor 0B1 NR0B1 0.0049
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0049
277 Purine nucleoside phosphorylase PNP 0.0049
2870 Purine nucleoside phosphorylase punA 0.0049
2945 Purine nucleoside phosphorylase punA 0.0049
4659 Purine nucleoside phosphorylase TM_1596 0.0049
4825 Purine nucleoside phosphorylase TTHA1435 0.0049
6131 Carbonic anhydrase 14 CA14 0.0048
4210 Toll-like receptor 4 TLR4 0.0048
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0048
819 Penicillin-binding protein 4 dacB 0.0048
5923 Microtubule-associated protein tau MAPT 0.0048
5924 Microtubule-associated protein 4 MAP4 0.0048
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0048
6288 Low molecular weight phosphotyrosine protein phosphatase ACP1 0.0048
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0047
3601 Dihydropteroate synthase 1 folP1 0.0047
3807 Dihydropteroate synthase 1 folP1 0.0047
3808 Dihydropteroate synthase 2 folP2 0.0047
6677 Myelin P2 protein PMP2 0.0047
4692 A/G-specific adenine glycosylase mutY 0.0047
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0047
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0047
6146 High affinity copper uptake protein 1 SLC31A1 0.0047
683 Potassium transporter GK0582 0.0047
6832 Serine/threonine-protein kinase SRPK2 SRPK2 0.0046
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0046
1770 Phospholipase C PLCL1 0.0046
2841 Phospholipase C plc 0.0046
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0046
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0046
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0046
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0046
199 Monocarboxylate transporter 8 SLC16A2 0.0046
173 Toll-like receptor 7 TLR7 0.0046
3686 Acyl-CoA thioesterase I precursor tesA 0.0045
1291 cAMP response element-binding protein CREB1 0.0045
6122 Carbonic anhydrase 3 CA3 0.0045
3760 Penicillin-binding protein 5 precursor dacA 0.0045
760 Fibroblast growth factor 1 FGF1 0.0044
6339 Ig kappa chain V-II region RPMI 6410 Not Available 0.0044
1650 Heme carrier protein 1 SLC46A1 0.0044
3957 Adenosine deaminase ADA 0.0044
2178 Metabotropic glutamate receptor 5 GRM5 0.0044
5645 DNA topoisomerase 4 subunit B parE 0.0044
6227 DNA topoisomerase 4 subunit B parE 0.0044
581 Cytochrome P450 2R1 CYP2R1 0.0043
5698 Riboflavin synthase alpha chain ribE 0.0043
714 Glutathione reductase, mitochondrial GSR 0.0042
4606 Purine trans deoxyribosylase ptd 0.0042
6218 Pannexin-1 PANX1 0.0041
887 DNA gyrase subunit B gyrB 0.0041
4150 DNA gyrase subunit B gyrB 0.0041
6225 DNA gyrase subunit B gyrB 0.0041
1864 RET proto-oncogene RET 0.0041
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0041
408 Riboflavin kinase RFK 0.0041
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0041
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0041
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0041
174 Sigma 1-type opioid receptor SIGMAR1 0.0041
3997 Cytochrome P450 24A1, mitochondrial CYP24A1 0.0041
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0041
106 Cannabinoid receptor 2 CNR2 0.004
3679 MTA/SAH nucleosidase mtnN 0.004
1958 S-methyl-5-thioadenosine phosphorylase MTAP 0.004
6824 Tyrosine-protein kinase Lyn LYN 0.004
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.004
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.004
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.004
6508 Putative uncharacterized protein srtB 0.004
6543 Putative uncharacterized protein tcp14 0.004
6615 Putative uncharacterized protein MT0785 0.004
6623 Putative uncharacterized protein Not Available 0.004
6806 Putative uncharacterized protein AGR_C_2535 0.004
6813 Putative uncharacterized protein SAV4671 0.004
6815 Putative uncharacterized protein AFE_1514 0.004
6819 Putative uncharacterized protein RUMGNA_03254 0.004
6825 Putative uncharacterized protein CV_3270 0.004
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.004
4161 Furin FURIN 0.004
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.004
775 Acetyl-CoA carboxylase 2 ACACB 0.004
564 Cellular retinoic acid-binding protein 1 CRABP1 0.004
1558 Transient receptor potential cation channel subfamily V member 1 TRPV1 0.004
563 Thyroid peroxidase TPO 0.0039
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0039
1129 C-C chemokine receptor type 5 CCR5 0.0039
1198 Serum paraoxonase/arylesterase 1 PON1 0.0039
6223 Penicillin-binding protein 1C pbpC 0.0039
128 Adenine phosphoribosyltransferase APRT 0.0038
6067 Penicillin binding protein 2a mecA 0.0038
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0038
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0038
605 Fumarate reductase flavoprotein subunit frdA 0.0038
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0038
3673 Fumarate reductase flavoprotein subunit fccA 0.0038
4912 Fumarate reductase flavoprotein subunit ifcA 0.0038
6549 Fumarate reductase flavoprotein subunit frdA 0.0038
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0038
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0038
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0038
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0038
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0038
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0038
85 Growth hormone receptor GHR 0.0038
3007 Carbonic anhydrase 12 CA12 0.0038
4205 Carbonic anhydrase 9 CA9 0.0038
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0038
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0037
5353 Glutamate decarboxylase alpha gadA 0.0037
3913 Glutamic acid decarboxylase GAD65 0.0037
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0036
489 Monocarboxylate transporter 2 SLC16A7 0.0036
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0036
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0036
3616 Fatty acid-binding protein, epidermal FABP5 0.0036
5431 Lipid binding protein Not Available 0.0036
5433 UPF0230 protein TM_1468 TM_1468 0.0036
5430 Hepatocyte nuclear factor 4-gamma HNF4G 0.0036
293 Gamma-glutamyl hydrolase GGH 0.0035
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0035
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0035
4226 Uridine phosphorylase 2 UPP2 0.0035
1025 Aquaporin-1 AQP1 0.0035
939 50S ribosomal protein L3 rplC 0.0035
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0035
6766 O-GlcNAcase BT_4395 BT_4395 0.0034
7 Nitric oxide synthase, inducible NOS2 0.0034
6599 HTH-type transcriptional regulator ttgR ttgR 0.0034
131 Synaptic vesicular amine transporter SLC18A2 0.0034
2207 Rhodopsin RHO 0.0033
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0033
822 Aldose reductase AKR1B1 0.0033
233 Potassium channel subfamily K member 2 KCNK2 0.0033
6459 Glycodelin PAEP 0.0033
5432 Trafficking protein particle complex subunit 3 TRAPPC3 0.0033
332 Beta-lactamase blaZ 0.0033
2478 Beta-lactamase ampC 0.0033
2613 Beta-lactamase ampC 0.0033
2635 Beta-lactamase ampC 0.0033
2700 Beta-lactamase penP 0.0033
5445 Beta-lactamase blaB 0.0033
6019 Beta-lactamase SHV-7 0.0033
6701 Beta-lactamase cphA 0.0033
4225 Uridine phosphorylase 1 UPP1 0.0033
6048 Troponin C, skeletal muscle TNNC2 0.0032
6105 3-oxo-5-beta-steroid 4-dehydrogenase AKR1D1 0.0032
2107 Microtubule-associated protein 1A MAP1A 0.0032
595 Fibrinogen alpha chain FGA 0.0032
1227 Cytochrome b MT-CYB 0.0031
6386 Cytochrome b petB 0.0031
6937 Cytochrome b MT-CYB 0.0031
674 Dihydroorotate dehydrogenase homolog, mitochondrial PFF0160c 0.0031
164 Histamine H4 receptor HRH4 0.0031
2264 Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase cobT 0.0031
342 P protein [Includes: DNA-directed DNA polymerase P 0.0031
612 P protein [Includes: DNA-directed DNA polymerase P 0.0031
735 Alanine aminotransferase 1 GPT 0.0031
3904 Alanine aminotransferase 2 GPT2 0.0031
2578 Tubulin beta-3 chain TUBB3 0.003
413 Amidophosphoribosyltransferase PPAT 0.003
2515 Amidophosphoribosyltransferase purF 0.003
3714 Amidophosphoribosyltransferase purF 0.003
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.003
2285 Streptogramin A acetyltransferase vatD 0.003
283 SEC14-like protein 2 SEC14L2 0.003
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.003
4228 Keratin, type II cytoskeletal 7 KRT7 0.003
2599 Tyrosine-protein kinase HCK HCK 0.003
3611 Cytidine deaminase cdd 0.003
3707 Cytidine deaminase cdd 0.003
4211 Cytidine deaminase CDA 0.003
654 Flavin reductase BLVRB 0.0029
2216 Fibroblast growth factor receptor 4 FGFR4 0.0029
3813 Fibrinogen gamma chain FGG 0.0029
3812 Fibrinogen beta chain [Contains: Fibrinopeptide B] FGB 0.0029
512 DNA-directed RNA polymerase alpha chain rpoA 0.0029
5772 DNA-directed RNA polymerase alpha chain rpoA 0.0029
3688 Branched-chain-amino-acid aminotransferase ilvE 0.0028
1435 Synaptic vesicle glycoprotein 2A SV2A 0.0028
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0028
1063 Signal transducer and activator of transcription 5B STAT5B 0.0028
1278 Pro-epidermal growth factor EGF 0.0028
1200 AMBP protein AMBP 0.0028
3866 Serum amyloid A protein SAA1 0.0028
1932 Apolipoprotein E APOE 0.0028
6232 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short GNAS 0.0027
6233 Adenylate cyclase type 2 ADCY2 0.0027
6234 Adenylate cyclase type 5 ADCY5 0.0027
1144 Hepatocyte growth factor receptor MET 0.0027
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0027
4173 Tyrosine-protein kinase JAK2 JAK2 0.0027
1405 Thiopurine S-methyltransferase TPMT 0.0027
2159 Quinone oxidoreductase CRYZ 0.0027
702 UMP-CMP kinase CMPK1 0.0027
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0027
3849 Insulin-like growth factor-binding protein 7 IGFBP7 0.0027
2009 Protein NOV homolog NOV 0.0027
3847 Neuroendocrine convertase 2 PCSK2 0.0027
1949 Carboxypeptidase E CPE 0.0027
3850 Synaptotagmin-like protein 4 SYTL4 0.0027
3848 Neuroendocrine convertase 1 PCSK1 0.0027
3846 Retinoblastoma-associated protein RB1 0.0027
1262 Corticotropin-lipotropin POMC 0.0027
3685 Catabolite gene activator crp 0.0027
4655 Adenylate cyclase cyaC 0.0027
4759 Adenylate cyclase cyaB2 0.0027
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0026
719 Retinoic acid receptor responder protein 1 RARRES1 0.0026
770 Retinoic acid-induced protein 3 GPRC5A 0.0026
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0026
790 DNA polymerase subunit alpha B POLA2 0.0026
5997 Tumor necrosis factor ligand superfamily member 11 TNFSF11 0.0026
6859 Protein S100-A4 S100A4 0.0025
484 Tyrosine-protein kinase ABL2 ABL2 0.0025
509 Thymidine kinase TK 0.0025
570 Thymidine kinase TK 0.0025
2559 Thymidine kinase TK 0.0025
3430 Thymidine kinase tdk 0.0025
3518 Thymidine kinase TK 0.0025
5301 Thymidine kinase tdk 0.0025
5771 Thymidine kinase ORF36 0.0025
7009 Thymidine kinase ORF36 0.0025
1385 Angiotensin-converting enzyme 2 ACE2 0.0025
6151 Monocarboxylate transporter 10 SLC16A10 0.0025
3830 Calreticulin CALR 0.0025
390 Adenosine A3 receptor ADORA3 0.0025
444 Alcohol dehydrogenase 1B ADH1B 0.0025
1374 Natriuretic peptides B NPPB 0.0025
1827 Gap junction alpha-1 protein GJA1 0.0025
1908 Vascular cell adhesion protein 1 VCAM1 0.0025
2300 Lysozyme E 0.0024
3633 Lysozyme R 0.0024
5597 Lysozyme 17 0.0024
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0024
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0024
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0024
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0024
544 Potassium voltage-gated channel subfamily E member 1 KCNE1 0.0024
251 Alcohol dehydrogenase 1A ADH1A 0.0024
6039 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A PDE11A 0.0024
471 Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) SLC6A14 0.0024
6231 Pepsin A PGA3 0.0024
6070 Nischarin NISCH 0.0024
268 Adenosine A2b receptor ADORA2B 0.0024
6034 Hydroxyindole O-methyltransferase ASMT 0.0023
6035 Nuclear receptor ROR-beta RORB 0.0023
6036 Eosinophil peroxidase EPX 0.0023
4221 Vascular endothelial growth factor VEGF 0.0023
5816 Cadherin-5 CDH5 0.0023
550 Amiloride-sensitive sodium channel subunit delta SCNN1D 0.0023
27 Amiloride-sensitive sodium channel subunit beta SCNN1B 0.0023
552 Amiloride-sensitive sodium channel subunit gamma SCNN1G 0.0023
213 Amiloride-sensitive sodium channel subunit alpha SCNN1A 0.0023
1830 5'-nucleotidase NT5E 0.0023
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0023
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0023
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0023
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0023
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0023
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0023
2249 Aspartate aminotransferase aspC 0.0023
2671 Aspartate aminotransferase aspC 0.0023
5490 Aspartate aminotransferase Not Available 0.0023
569 Retinal dehydrogenase 2 ALDH1A2 0.0023
6501 Fatty acid-binding protein, liver FABP1 0.0023
751 Potassium channel subfamily K member 6 KCNK6 0.0023
820 Glycine receptor subunit alpha-2 GLRA2 0.0023
4760 Mll3241 protein mll3241 0.0023
1507 Cytochrome c CYCS 0.0022
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0022
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0022
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0022
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.0022
611 Retinal dehydrogenase 1 ALDH1A1 0.0022
2461 D-alanyl-D-alanine carboxypeptidase Not Available 0.0022
5756 D-alanyl-D-alanine carboxypeptidase dac 0.0022
2155 Insulin-degrading enzyme IDE 0.0022
2232 Interleukin-5 IL5 0.0022
298 Renin REN 0.0021
1593 Mucin-2 MUC2 0.0021
6506 Stathmin-4 STMN4 0.0021
2091 Endoplasmin HSP90B1 0.0021
718 Folate receptor gamma FOLR3 0.0021
299 Folate receptor beta FOLR2 0.0021
804 Mitochondrial folate transporter/carrier SLC25A32 0.0021
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0021
172 Potassium channel subfamily K member 1 KCNK1 0.0021
331 Retinol-binding protein I, cellular RBP1 0.0021
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0021
828 Phenylalanine-4-hydroxylase PAH 0.0021
3109 Phenylalanine-4-hydroxylase phhA 0.0021
517 Alcohol dehydrogenase 1C ADH1C 0.002
765 Indoleamine 2,3-dioxygenase IDO1 0.002
672 Prostaglandin F2-alpha receptor PTGFR 0.002
3090 Chitosanase csn 0.002
4149 Nuclear factor NF-kappa-B p100 subunit NFKB2 0.002
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.002
2236 Casein kinase II subunit alpha CSNK2A1 0.002
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.002
1820 Beta-nerve growth factor NGF 0.002
6755 Poliovirus receptor PVR 0.002
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.002
5818 Folate receptor alpha FOLR1 0.0019
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0019
867 Penicillin-binding protein 3 pbpC 0.0019
6119 Penicillin-binding protein 3 pbp3 0.0019
7154 Penicillin-binding protein 3 pbp3 0.0019
7157 Penicillin-binding protein 3 LMHCC_2184 0.0019
7162 Penicillin-binding protein 3 pbpB 0.0019
7172 Penicillin-binding protein 3 pbp3 0.0019
461 Glycine receptor subunit alpha-3 GLRA3 0.0019
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0019
1654 Interleukin-1 beta IL1B 0.0019
896 Glutathione S-transferase Mu 1 GSTM1 0.0018
1253 Interferon gamma IFNG 0.0018
1968 ATP-sensitive inward rectifier potassium channel 12 KCNJ12 0.0018
3312 Fatty acid-binding protein, brain FABP7 0.0018
53 Solute carrier family 12 member 5 SLC12A5 0.0018
663 Solute carrier family 12 member 4 SLC12A4 0.0018
1123 Eosinophil cationic protein RNASE3 0.0018
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.0017
291 Nitric-oxide synthase, endothelial NOS3 0.0017
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0017
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0017
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0017
144 Hemoglobin subunit alpha HBA1 0.0017
1360 Sphingomyelin phosphodiesterase SMPD1 0.0017
310 Solute carrier family 12 member 2 SLC12A2 0.0017
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.0016
6837 Serine/threonine-protein kinase 17B STK17B 0.0016
78 Acetyl-CoA acetyltransferase, mitochondrial ACAT1 0.0016
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0016
1268 Neuropeptide S receptor NPSR1 0.0016
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0016
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0016
2408 Tyrosine-protein kinase SYK SYK 0.0016
6228 Nuclear receptor coactivator 1 NCOA1 0.0016
1243 Cathepsin D CTSD 0.0016
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.0016
2297 Genome polyprotein Not Available 0.0016
2322 Genome polyprotein Not Available 0.0016
2694 Genome polyprotein Not Available 0.0016
2719 Genome polyprotein Not Available 0.0016
2860 Genome polyprotein Not Available 0.0016
2928 Genome polyprotein Not Available 0.0016
3160 Genome polyprotein Not Available 0.0016
3260 Genome polyprotein Not Available 0.0016
4783 Genome polyprotein Not Available 0.0016
5726 Genome polyprotein Not Available 0.0016
5779 Genome polyprotein Not Available 0.0016
5867 Genome polyprotein Not Available 0.0016
6253 Genome polyprotein Not Available 0.0016
6301 Genome polyprotein Not Available 0.0016
6380 Genome polyprotein Not Available 0.0016
6381 Genome polyprotein Not Available 0.0016
6437 Genome polyprotein Not Available 0.0016
6520 Genome polyprotein Not Available 0.0016
6521 Genome polyprotein Not Available 0.0016
6652 Genome polyprotein Not Available 0.0016
6734 Genome polyprotein Not Available 0.0016
6735 Genome polyprotein Not Available 0.0016
6736 Genome polyprotein Not Available 0.0016
6737 Genome polyprotein Not Available 0.0016
6738 Genome polyprotein Not Available 0.0016
6739 Genome polyprotein Not Available 0.0016
6744 Genome polyprotein Not Available 0.0016
6748 Genome polyprotein Not Available 0.0016
6894 Genome polyprotein Not Available 0.0016
6898 Genome polyprotein Not Available 0.0016
494 Caspase-1 CASP1 0.0015
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0015
3587 Gastrotropin FABP6 0.0015
3844 HLA class II histocompatibility antigen, DQ(6) alpha chain HLA-DQA2 0.0015
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0015
6073 Potassium channel subfamily K member 9 KCNK9 0.0015
6072 Potassium channel subfamily K member 3 KCNK3 0.0015
1569 G1/S-specific cyclin-D1 CCND1 0.0015
1341 Histamine H3 receptor HRH3 0.0014
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.0014
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0014
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0014
2129 Sucrase-isomaltase, intestinal SI 0.0014
3221 Cytochrome c4 cc4 0.0014
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0013
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0013
6163 Copper-transporting ATPase 2 ATP7B 0.0013
6165 Copper-transporting ATPase 1 ATP7A 0.0013
6211 Tubulin epsilon chain TUBE1 0.0013
6212 Tubulin gamma-1 chain TUBG1 0.0013
6210 Tubulin delta chain TUBD1 0.0013
6241 Nuclear receptor coactivator 2 NCOA2 0.0013
2077 Caspase-3 CASP3 0.0013
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0013
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0013
6116 Gastric triacylglycerol lipase LIPF 0.0012
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0012
694 Matrix protein 2 M 0.0012
2240 Cell division protein kinase 2 CDK2 0.0012
3823 Cytokine receptor common gamma chain IL2RG 0.0012
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0012
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0012
1295 Fatty acid synthase FASN 0.0012
4948 Cytochrome c-553 Not Available 0.0012
4923 Cytochrome c3 DvMF_2499 0.0012
4945 Cytochrome c3 Not Available 0.0012
4949 Cytochrome c3 DVU_3171 0.0012
4968 Cytochrome c3 cytc3 0.0012
4997 Cytochrome c3 SO_2727 0.0012
5219 Cytochrome c3 cyd 0.0012
4902 Nine-heme cytochrome c Ddes_2038 0.0012
3189 High-molecular-weight cytochrome c hmcA 0.0012
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.0012
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.0012
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.0012
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0012
754 Pancreatic triacylglycerol lipase PNLIP 0.0011
724 Interleukin-2 receptor alpha chain IL2RA 0.0011
717 Interleukin-2 receptor subunit beta IL2RB 0.0011
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.001
1810 Protein S100-A1 S100A1 0.001
6097 Protein S100-A2 S100A2 0.001
997 Protein kinase C beta type PRKCB 0.001
4386 Hemoglobin-like protein HbN glbN 0.001
493 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial CYP27B1 0.001
4041 Microsomal glutathione S-transferase 2 MGST2 0.001
1176 Mitogen-activated protein kinase 1 MAPK1 0.001
2473 Tyrosine-protein kinase CSK CSK 0.001
2398 Tyrosine-protein kinase ZAP-70 ZAP70 0.001
2298 Cytochrome P450-cam camC 0.001
1970 Protein kinase C alpha type PRKCA 0.001
2268 Cholesterol oxidase choB 0.0009
2822 Cholesterol oxidase choA 0.0009
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.0009
1048 Protein S100-A13 S100A13 0.0009
2226 Protein S100-A12 S100A12 0.0009
2283 Steroid Delta-isomerase ksi 0.0009
2920 Steroid Delta-isomerase ksi 0.0009
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.0009
6171 Solute carrier family 28 member 3 SLC28A3 0.0009
2132 Protein S100-B S100B 0.0009
3404 Exotoxin A eta 0.0008
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0008
2325 Sulfotransferase family cytosolic 2B member 1 SULT2B1 0.0008
4954 Soluble cytochrome b558 Not Available 0.0008
4943 Cytochrome c6 petJ 0.0008
4916 Cyanoglobin glbN 0.0008
4947 Bacterial hemoglobin vhb 0.0008
4934 Cytochrome c-551 nirM 0.0008
5218 Cytochrome c-551 nirM 0.0008
4915 Cytochrome c-550 psbV 0.0008
4959 Cytochrome c-550 psbV 0.0008
5216 Cytochrome c-550 psbV 0.0008
4925 Cytochrome c-type protein SHP shp 0.0008
5000 HemO hemO 0.0008
4975 Cytochrome c-556 RPA3973 0.0008
4936 Cytochrome c2 iso-2 Not Available 0.0008
4994 Hemoglobin-like protein HbO glbO 0.0008
4905 Cytochrome c2 Not Available 0.0008
4939 Cytochrome c2 cycA 0.0008
4964 Cytochrome c2 cycA 0.0008
4979 Cytochrome c2 cycA 0.0008
6673 Cytochrome c2 cycA 0.0008
4942 Diheme cytochrome c napB napB 0.0008
4984 Neuroglobin NGB 0.0008
4981 Iron-starvation protein PigA pigA 0.0008
4998 Hemoglobin-like protein yjbI yjbI 0.0008
4935 Cytochrome c-554 cycA1 0.0008
4909 CooA protein cooA 0.0008
4910 Cytoglobin CYGB 0.0008
4961 Hemophore HasA hasA 0.0008
4904 Cytochrome c family protein GSU1996 0.0008
644 Heme oxygenase 2 HMOX2 0.0008
4982 Heme oxygenase 2 pbsA2 0.0008
4971 Nonaheme cytochrome c hmcA 0.0008
4907 Cytochrome c-L moxG 0.0008
6865 Cytochrome c-L moxG 0.0008
4937 Cytochrome oxidase subunit II rcoxA 0.0008
4989 Cytochrome c551 peroxidase ccp 0.0008
5222 Cytochrome c551 peroxidase ccpA 0.0008
4931 Cytochrome P450 167A1 CYP167A1 0.0008
4976 Apocytochrome f petA 0.0008
6407 Apocytochrome f petA 0.0008
4764 Cytochrome P450 165C4 CYP165C4 0.0008
4999 Cytochrome P450 165B3 CYP165B3 0.0008
4960 Putative cytochrome P450-family protein SCO7417 0.0008
4903 Methyl-accepting chemotaxis protein Tar4 0.0008
4922 Cytochrome c, putative SO_4144 0.0008
4926 Heme-based aerotactic transducer hemAT hemAT 0.0008
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0008
4972 P450cin cinA 0.0008
4993 Hydroxylamine oxidoreductase hao1 0.0008
4952 Catalase/peroxidase katA 0.0008
3093 Catalase HPII katE 0.0008
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0008
4031 Glutathione S-transferase A1 GSTA1 0.0008
1649 Small inducible cytokine A2 CCL2 0.0008
2530 Protein kinase C theta type PRKCQ 0.0008
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0008
400 Coagulation factor IX F9 0.0008
5461 Coagulation factor IX F9 0.0008
473 L-lactate dehydrogenase A chain LDHA 0.0007
6316 ADP-ribosylation factor 1 ARF1 0.0007
4081 Vitamin K epoxide reductase complex subunit 1-like protein 1 VKORC1L1 0.0007
604 Vitamin K-dependent protein Z PROZ 0.0007
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0007
76 Nitric-oxide synthase, brain NOS1 0.0007
6134 Sodium channel subunit beta-3 SCN3B 0.0007
6133 Sodium channel subunit beta-2 SCN2B 0.0007
6135 Sodium channel subunit beta-4 SCN4B 0.0007
6132 Sodium channel subunit beta-1 SCN1B 0.0007
6129 Carbonic anhydrase-related protein 11 CA11 0.0007
6127 Carbonic anhydrase-related protein CA8 0.0007
6128 Carbonic anhydrase-related protein 10 CA10 0.0007
2511 MAP kinase-activated protein kinase 2 MAPKAPK2 0.0007
2290 ADP-ribosyl cyclase 2 BST1 0.0007
226 Gonadotropin-releasing hormone receptor GNRHR 0.0007
125 DNA polymerase beta POLB 0.0007
1245 Vitamin K-dependent protein S PROS1 0.0006
422 Vitamin K-dependent protein C PROC 0.0006
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0006
6130 Carbonic anhydrase 13 CA13 0.0006
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0006
4920 Peroxidase/catalase katG 0.0006
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0006
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0006
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0006
6168 Solute carrier family 22 member 16 SLC22A16 0.0006
2119 Cytochrome b5 CYB5A 0.0006
4990 PpcA ppcA 0.0006
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0006
3375 Acidic cytochrome c3 Not Available 0.0006
4988 Sulfite oxidase, mitochondrial SUOX 0.0006
2915 Sensor protein fixL fixL 0.0006
4944 Sensor protein fixL fixL 0.0006
3570 Cytochrome P450 152A1 cypC 0.0006
4037 Hypothetical protein GPX1 0.0006
4297 Hypothetical protein SP_1951 0.0006
4521 Hypothetical protein BC_2969 0.0006
4540 Hypothetical protein TM_1070 0.0006
4555 Hypothetical protein MT1739 0.0006
4569 Hypothetical protein mshD 0.0006
4578 Hypothetical protein PA3270 0.0006
4747 Hypothetical protein PA3967 0.0006
5177 Hypothetical protein TM_0096 0.0006
5194 Hypothetical protein PA1204 0.0006
5240 Hypothetical protein Rv2991 0.0006
5370 Hypothetical protein TM_1158 0.0006
5710 Hypothetical protein Tb927.5.1360 0.0006
4813 Heme oxygenase hmuO 0.0006
5769 Heme oxygenase Not Available 0.0006
4385 Cytochrome c' Not Available 0.0006
4967 Cytochrome c' cycA 0.0006
5038 Cytochrome c' Not Available 0.0006
5223 Cytochrome c' cycP 0.0006
4289 Cytochrome P450 TT_P0059 0.0006
6262 Cytochrome P450 staP 0.0006
4992 Cytochrome c peroxidase Not Available 0.0006
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0006
448 Vitamin K-dependent gamma-carboxylase GGCX 0.0006
2230 Catalase CAT 0.0006
3249 Catalase katA 0.0006
3625 Catalase katA 0.0006
4539 Catalase katA 0.0006
4941 Catalase katB 0.0006
5221 Cytochrome c3, 13 kDa Not Available 0.0006
3152 Cytochrome c'' cycA 0.0006
5220 Split-Soret cytochrome c Ddes_2150 0.0006
3700 Cytochrome c-552 precursor nrfA 0.0006
1721 Glycogen synthase kinase-3 beta GSK3B 0.0005
3238 Multidrug resistance protein mexA mexA 0.0005
3116 Bacterioferritin bfr 0.0005
4906 Bacterioferritin bfr 0.0005
4965 Bacterioferritin bfr 0.0005
3173 Enolase eno 0.0005
3709 Glycerol uptake facilitator protein glpF 0.0005
3336 C4-dicarboxylate transport transcriptional regulatory protein dctD dctD 0.0005
3393 TGF-beta receptor type-2 TGFBR2 0.0005
5489 Ribonucleoside-diphosphate reductase 1 subunit beta nrdB 0.0005
6743 Non-fluorescent flavoprotein luxF 0.0005
6753 Apolipoprotein M APOM 0.0005
2528 Fatty acid metabolism regulator protein fadR 0.0005
6740 Fatty acid metabolism regulator protein fadR 0.0005
6752 Guanylyl cyclase-activating protein 1 GUCA1A 0.0005
394 Calcineurin subunit B isoform 1 PPP3R1 0.0005
6742 Recoverin RCVRN 0.0005
6747 Chalcone/stilbene synthase family protein MT1417 0.0005
6741 Peroxisomal 3,2-trans-enoyl-CoA isomerase PECI 0.0005
6522 Hepatocyte nuclear factor 4-alpha HNF4A 0.0005
6751 Gag polyprotein gag 0.0005
6746 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform PPP3CA 0.0005
6749 Polyprotein Not Available 0.0005
798 Osteocalcin BGLAP 0.0005
3670 Soluble cytochrome b562 precursor cybC 0.0005
3411 Cytochrome P450 121 cyp121 0.0005
3291 Cytochrome c-552 cycA 0.0005
4927 Cytochrome c-552 nrfA 0.0005
4938 Cytochrome c-552 cycA 0.0005
4953 Cytochrome c-552 nrfA 0.0005
5217 Cytochrome c-552 cycM 0.0005
2617 Nitric oxide synthase oxygenase nos 0.0005
2701 Nitric oxide synthase oxygenase nos 0.0005
3102 Flavohemoprotein hmp 0.0005
4969 Flavohemoprotein hmp 0.0005
3127 Nitrite reductase nirS 0.0005
3284 Nitrite reductase nirS 0.0005
2852 DNA mismatch repair protein mutL mutL 0.0005
5961 Insulin INS 0.0005
369 Coagulation factor VII F7 0.0005
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0005
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0005
6527 Lymphocyte antigen 96 LY96 0.0005
3191 Histidinol dehydrogenase hisD 0.0005
2972 6-deoxyerythronolide B hydroxylase eryF 0.0005
4608 Putative cytochrome P450 SCO1207 0.0004
4963 Putative cytochrome P450 SCO2884 0.0004
6254 Putative cytochrome P450 SCO6998 0.0004
3405 Quinohaemoprotein ethanol dehydrogenase type-1 qheDH 0.0004
6750 ADP-ribosylation factor 6 ARF6 0.0004
4373 Medium-chain-fatty-acid--CoA ligase Not Available 0.0004
6524 Protein tonB tonB 0.0004
358 Cystathionine beta-synthase CBS 0.0004
2435 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase lpxC 0.0004
6613 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase lpxC 0.0004
693 Hemoglobin subunit beta HBB 0.0004
2802 Endoglucanase G celCCG 0.0004
340 Apoptotic protease-activating factor 1 APAF1 0.0004
2391 Ferrochelatase hemH 0.0004
6502 Ferrochelatase DKFZp686P18130 0.0004
1591 Ferrochelatase, mitochondrial FECH 0.0004
6268 Hydroxyacid oxidase 1 HAO1 0.0004
810 Heme oxygenase 1 HMOX1 0.0004
3391 Heme oxygenase 1 pbsA1 0.0004
864 Gag-Pol polyprotein gag-pol 0.0003
2237 Gag-Pol polyprotein gag-pol 0.0003
2326 Gag-Pol polyprotein gag-pol 0.0003
2451 Gag-Pol polyprotein gag-pol 0.0003
2901 Gag-Pol polyprotein gag-pol 0.0003
3165 Gag-Pol polyprotein gag-pol 0.0003
3722 Gag-Pol polyprotein gag-pol 0.0003
6306 Gag-Pol polyprotein gag-pol 0.0003
6624 Gag-Pol polyprotein gag-pol 0.0003
2101 Glutathione-requiring prostaglandin D synthase HPGDS 0.0003
825 Arsenical pump-driving ATPase ASNA1 0.0003
3435 Arsenical pump-driving ATPase arsA 0.0003
486 Serine/threonine-protein kinase ALS2CR7 CDK15 0.0003
2105 ATP-binding cassette sub-family G member 1 ABCG1 0.0003
377 Beta-adrenergic receptor kinase 1 ADRBK1 0.0003
510 Serine/threonine-protein kinase receptor R3 ACVRL1 0.0003
733 Activin receptor type 1B ACVR1B 0.0003
225 NEDD8-activating enzyme E1 regulatory subunit NAE1 0.0003
745 Anti-Muellerian hormone type-2 receptor AMHR2 0.0003
483 A-Raf proto-oncogene serine/threonine-protein kinase ARAF 0.0003
21 Beta-adrenergic receptor kinase 2 ADRBK2 0.0003
154 AFG3-like protein 2 AFG3L2 0.0003
395 ALK tyrosine kinase receptor Not Available 0.0003
6496 Cytochrome c oxidase subunit 8A, mitochondrial COX8A 0.0003
6493 Cytochrome c oxidase subunit 6C COX6C 0.0003
6495 Cytochrome c oxidase subunit 7C, mitochondrial COX7C 0.0003
6499 Cytochrome c oxidase polypeptide 7A1, mitochondrial COX7A1 0.0003
6494 Cytochrome c oxidase subunit 7B, mitochondrial COX7B 0.0003
6491 Cytochrome c oxidase subunit 5A, mitochondrial COX5A 0.0003
6498 Cytochrome c oxidase subunit 6B1 COX6B1 0.0003
6497 Cytochrome c oxidase subunit 6A2, mitochondrial COX6A2 0.0003
6489 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial COX4I1 0.0003
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.0003
6559 Cytochrome c oxidase subunit 2 ctaC 0.0003
6669 Cytochrome c oxidase subunit 2 ctaC 0.0003
6490 Cytochrome c oxidase subunit 3 MT-CO3 0.0003
371 Cytochrome c oxidase subunit 1 MT-CO1 0.0003
6558 Cytochrome c oxidase subunit 1 ctaD 0.0003
292 Activin receptor type-1 ACVR1 0.0003
849 Activated CDC42 kinase 1 TNK2 0.0003
2540 Choloylglycine hydrolase cbh 0.0003
2427 Ferrichrome-iron receptor fhuA 0.0003
704 Long-chain-fatty-acid--CoA ligase 1 ACSL1 0.0003
821 Acetyl-coenzyme A synthetase 2-like, mitochondrial ACSS1 0.0003
386 Acetyl-coenzyme A synthetase, cytoplasmic ACSS2 0.0003
297 Adenylate cyclase type 1 ADCY1 0.0003
289 Cytosolic purine 5'-nucleotidase NT5C2 0.0003
6264 cAMP-dependent protein kinase inhibitor alpha PKIA 0.0003
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.0003
740 Argininosuccinate synthase ASS1 0.0002
865 Argininosuccinate synthase ASS1 0.0002
2680 Argininosuccinate synthase argG 0.0002
3194 Argininosuccinate synthase argG 0.0002
661 ADP/ATP translocase 1 SLC25A4 0.0002
6021 Adenosine kinase ADK 0.0002
242 Asparagine synthetase [glutamine-hydrolyzing] ASNS 0.0002
6500 Phospholipase A2 PLA2G1B 0.0002
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