DT-Web: DB01039

Identification

Name

Fenofibrate

Accession Number

DB01039 (APRD00405)

Type

small molecule

Description

An antilipemic agent which reduces both cholesterol and triglycerides in the blood. [PubChem]

Structure

MOL SDF PDB SMILES InChI

Categories ^(*)

Molecular Weight

360.831

Groups

approved

Monoisotopic Weight

360.112836867

Pharmacology

Indication

For use as adjunctive therapy to diet to reduce elevated LDL-C, Total-C,Triglycerides and Apo B, and to increase HDL-C in adult patients with primary hypercholesterolemia or mixed dyslipidemia (Fredrickson Types IIa and IIb)

Mechanism of action

Fenofibrate exerts its therapeutic effects through activation of peroxisome proliferator activated receptor a (PPARa). This increases lipolysis and elimination of triglyceride-rich particles from plasma by activating lipoprotein lipase and reducing production of apoprotein C-III. The resulting fall in triglycerides produces an alteration in the size and composition of LDL from small, dense particles, to large buoyant particles. These larger particles have a greater affinity for cholesterol receptors and are catabolized rapidly.

Absorption

Fenofibrate is well absorbed from the gastrointestinal tract. After absorption, fenofibrate is mainly excreted in the urine in the form of metabolites, primarily fenofibric acid and fenofibric acid glucuronide

Protein binding

~99% (Serum protein binding)

Biotransformation

Not Available

Route of elimination

Fenofibric acid is primarily conjugated with glucuronic acid and then excreted in urine. Following oral administration in healthy volunteers, approximately 60% of a single dose of radiolabelled fenofibrate appeared in urine, primarily as fenofibric acid and its glucuronate conjugate and 25% was excreted in the feces.

Toxicity

LD₅₀=1600 mg/kg (Oral, in mice); Investigated as a teratogen and reproductive hazard.

Affected organisms

Humans and other mammals

Interactions

Drug Interactions

Drug	Mechanism of interaction
Acenocoumarol	Fenofibrate may increase the anticoagulant effect of acenocoumarol.
Anisindione	Fenofibrate may increase the anticoagulant effect of anisindione.
Atorvastatin	Increased risk of myopathy/rhabdomyolysis
Cerivastatin	Increased risk of myopathy/rhabdomyolysis
Dicumarol	Fenofibrate may increase the anticoagulant effect of dicumarol.
Fluvastatin	Increased risk of myopathy/rhabdomyolysis
Insulin Lispro	Concomitant therapy with drugs that may increase the blood-glucose-lowering effect of insulin lispro and thus the chance of hypoglycemia should be monitored closely.
Lovastatin	Increased risk of myopathy/rhabdomyolysis
Pitavastatin	Increased incidence of adverse drug reactions (ie. rhabdomyolysis) of both fenofibrate and pitavastatin via pharmacodynamic synergism. Use alternative therapy.
Pravastatin	Increased risk of myopathy/rhabdomyolysis
Rosuvastatin	May cause additive myotoxicity. Monitor for symptoms of muscle toxicity during concomitant therapy.
Simvastatin	Increased risk of myopathy/rhabdomyolysis
Ursodeoxycholic acid	The fibric acid derivative decreases the effect of ursodiol
Warfarin	Fenofibrate may increase the anticoagulant effect of warfarin. Monitor prothrombin time and therapeutic and adverse effects of warfarin if fenofibrate is initiated, discontinued or dose changed.

Food Interactions

Increased absorption- take with meals.

Peroxisome proliferator-activated receptor alpha
Name	Peroxisome proliferator-activated receptor alpha
Gene Name	PPARA
Pharmacological action	yes
Actions	agonist
References	Clavey V, Copin C, Mariotte MC, Bauge E, Chinetti G, Fruchart J, Fruchart JC, Dallongeville J, Staels B: Cell culture conditions determine apolipoprotein CIII secretion and regulation by fibrates in human hepatoma HepG2 cells. Cell Physiol Biochem. 1999;9(3):139-49. - Pubmed Chaput E, Saladin R, Silvestre M, Edgar AD: Fenofibrate and rosiglitazone lower serum triglycerides with opposing effects on body weight. Biochem Biophys Res Commun. 2000 May 10;271(2):445-50. - Pubmed Casas F, Pineau T, Rochard P, Rodier A, Daury L, Dauca M, Cabello G, Wrutniak-Cabello C: New molecular aspects of regulation of mitochondrial activity by fenofibrate and fasting. FEBS Lett. 2000 Sep 29;482(1-2):71-4. - Pubmed Bouly M, Masson D, Gross B, Jiang XC, Fievet C, Castro G, Tall AR, Fruchart JC, Staels B, Lagrost L, Luc G: Induction of the phospholipid transfer protein gene accounts for the high density lipoprotein enlargement in mice treated with fenofibrate. J Biol Chem. 2001 Jul 13;276(28):25841-7. Epub 2001 May 7. - Pubmed Dana SL, Hoener PA, Bilakovics JM, Crombie DL, Ogilvie KM, Kauffman RF, Mukherjee R, Paterniti JR Jr: Peroxisome proliferator-activated receptor subtype-specific regulation of hepatic and peripheral gene expression in the Zucker diabetic fatty rat. Metabolism. 2001 Aug;50(8):963-71. - Pubmed Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed Guerre-Millo M, Gervois P, Raspe E, Madsen L, Poulain P, Derudas B, Herbert JM, Winegar DA, Willson TM, Fruchart JC, Berge RK, Staels B: Peroxisome proliferator-activated receptor alpha activators improve insulin sensitivity and reduce adiposity. J Biol Chem. 2000 Jun 2;275(22):16638-42. - Pubmed
DTHybrid score	0.6172
Metalloproteinase
Name	Metalloproteinase
Gene Name	mmp20
Pharmacological action	unknown
Actions	inhibitor
References	Duhaney TA, Cui L, Rude MK, Lebrasseur NK, Ngoy S, De Silva DS, Siwik DA, Liao R, Sam F: Peroxisome proliferator-activated receptor alpha-independent actions of fenofibrate exacerbates left ventricular dilation and fibrosis in chronic pressure overload. Hypertension. 2007 May;49(5):1084-94. Epub 2007 Mar 12. - Pubmed Lebrasseur NK, Duhaney TA, De Silva DS, Cui L, Ip PC, Joseph L, Sam F: Effects of fenofibrate on cardiac remodeling in aldosterone-induced hypertension. Hypertension. 2007 Sep;50(3):489-96. Epub 2007 Jul 2. - Pubmed
DTHybrid score	0.4542

Cytochrome P450 2C8
Name	Cytochrome P450 2C8
Gene Name	CYP2C8
Actions	inhibitor
References	Walsky RL, Gaman EA, Obach RS: Examination of 209 drugs for inhibition of cytochrome P450 2C8. J Clin Pharmacol. 2005 Jan;45(1):68-78. - Pubmed Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.3503
Cytochrome P450 2C9
Name	Cytochrome P450 2C9
Gene Name	CYP2C9
Actions	inhibitor
References	Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.4074
Cytochrome P450 3A4
Name	Cytochrome P450 3A4
Gene Name	CYP3A4
Actions	substrate
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.4747

Id	Partner name	Gene Name	Score
6016	Cytochrome P450 2C19	CYP2C19	0.1719
6228	Nuclear receptor coactivator 1	NCOA1	0.1545
4119	Cytochrome P450 2D6	CYP2D6	0.1494
4200	Cytochrome P450 1A2	CYP1A2	0.1265
1588	Multidrug resistance protein 1	ABCB1	0.1164
5841	Insulin-like growth factor IB	IGF1	0.1126
4118	Cytochrome P450 3A5	CYP3A5	0.1065
238	Peroxisome proliferator-activated receptor gamma	PPARG	0.0997
6030	Cytochrome P450 2B6	CYP2B6	0.0974
6013	Cytochrome P450 2E1	CYP2E1	0.0846
6107	Cytochrome P450 3A7	CYP3A7	0.0753
6024	Cytochrome P450 1A1	CYP1A1	0.0696
1502	Peroxisome proliferator-activated receptor delta	PPARD	0.0682
20	Prostaglandin G/H synthase 1	PTGS1	0.064
5718	Cytochrome P450 2A6	CYP2A6	0.0618
1490	Solute carrier organic anion transporter family member 1B1	SLCO1B1	0.0616
587	Serum albumin	ALB	0.054
1732	ATP-binding cassette sub-family G member 2	ABCG2	0.0416
290	Prostaglandin G/H synthase 2	PTGS2	0.0355
6106	Cytochrome P450 2C18	CYP2C18	0.0337
1735	Canalicular multispecific organic anion transporter 1	ABCC2	0.0292
1181	Alpha-1-acid glycoprotein 1	ORM1	0.0272
1729	Solute carrier family 22 member 6	SLC22A6	0.0269
492	Histamine H1 receptor	HRH1	0.0265
468	Cytochrome P450 4A11	CYP4A11	0.0264
6139	Solute carrier organic anion transporter family member 1A2	SLCO1A2	0.0262
3811	Cytochrome P450 19A1	CYP19A1	0.0251
6022	UDP-glucuronosyltransferase 1-1	UGT1A1	0.025
862	Multidrug resistance-associated protein 1	ABCC1	0.0247
136	Estrogen receptor	ESR1	0.0232
871	Glucocorticoid receptor	NR3C1	0.0215
6178	UDP-glucuronosyltransferase 2B7	UGT2B7	0.0212
3932	Glutathione S-transferase A2	GSTA2	0.0209
6018	UDP-glucuronosyltransferase 1-9	UGT1A9	0.0207
824	Sodium-dependent serotonin transporter	SLC6A4	0.02
1898	Cytochrome P450 1B1	CYP1B1	0.0197
6176	UDP-glucuronosyltransferase 1-3	UGT1A3	0.0191
540	Sodium-dependent noradrenaline transporter	SLC6A2	0.0182
220	Sodium channel protein type 5 subunit alpha	SCN5A	0.018
2164	Multidrug resistance-associated protein 4	ABCC4	0.0177
502	5-hydroxytryptamine 2A receptor	HTR2A	0.0175
872	Gamma-aminobutyric-acid receptor subunit alpha-1	GABRA1	0.0173
776	Bile salt export pump	ABCB11	0.0169
6157	Solute carrier organic anion transporter family member 1B3	SLCO1B3	0.0166
6142	Solute carrier family 22 member 8	SLC22A8	0.0165
731	HIV-1 protease	HIV-1 protease	0.0163
847	Mu-type opioid receptor	OPRM1	0.016
101	Potassium voltage-gated channel subfamily H member 2	KCNH2	0.0155
467	Delta-type opioid receptor	OPRD1	0.0149
51	Muscarinic acetylcholine receptor M3	CHRM3	0.0146
891	Dihydropteroate synthase	folP	0.0146
5359	Dihydropteroate synthase	folP	0.0146
7175	Dihydropteroate synthase	sulI	0.0146
831	D(2) dopamine receptor	DRD2	0.0146
6145	Solute carrier family 22 member 1	SLC22A1	0.0145
696	Kappa-type opioid receptor	OPRK1	0.0138
103	Muscarinic acetylcholine receptor M1	CHRM1	0.0137
556	Alpha-1A adrenergic receptor	ADRA1A	0.0136
580	Gamma-aminobutyric-acid receptor subunit alpha-3	GABRA3	0.0135
423	Gamma-aminobutyric-acid receptor subunit alpha-2	GABRA2	0.0135
6143	Solute carrier family 22 member 7	SLC22A7	0.0134
122	P2Y purinoceptor 12	P2RY12	0.0134
1632	Solute carrier organic anion transporter family member 2B1	SLCO2B1	0.0133
617	Muscarinic acetylcholine receptor M2	CHRM2	0.013
260	Cytochrome P450 51	ERG11	0.0129
761	Cytochrome P450 51	ERG11	0.0129
3163	Cytochrome P450 51	cyp51	0.0129
341	5-hydroxytryptamine 3 receptor	HTR3A	0.0129
6144	Solute carrier family 22 member 2	SLC22A2	0.0128
523	Gamma-aminobutyric-acid receptor subunit alpha-5	GABRA5	0.0127
230	ATP-binding cassette transporter sub-family C member 8	ABCC8	0.0127
70	Type-1 angiotensin II receptor	AGTR1	0.0126
6017	Cholesterol side-chain cleavage enzyme, mitochondrial	CYP11A1	0.0124
318	Alpha-2A adrenergic receptor	ADRA2A	0.0121
1709	Canalicular multispecific organic anion transporter 2	ABCC3	0.012
6031	Cytochrome P450 3A43	CYP3A43	0.0118
590	5-hydroxytryptamine 2C receptor	HTR2C	0.0112
1024	Solute carrier family 22 member 11	SLC22A11	0.0111
787	Vitamin K epoxide reductase complex subunit 1	VKORC1	0.0111
6182	Cytochrome P450 2J2	CYP2J2	0.0106
118	Organic cation/carnitine transporter 2	SLC22A5	0.0104
146	Androgen receptor	AR	0.0104
713	Sodium-dependent dopamine transporter	SLC6A3	0.0103
320	5-hydroxytryptamine 1A receptor	HTR1A	0.0102
632	Alpha-1B adrenergic receptor	ADRA1B	0.0101
274	Muscarinic acetylcholine receptor M5	CHRM5	0.01
4115	Voltage-dependent L-type calcium channel subunit alpha-1D	CACNA1D	0.01
811	Translocator protein	TSPO	0.01
805	Cytochrome P450 11B1, mitochondrial	CYP11B1	0.01
23	D(1A) dopamine receptor	DRD1	0.0099
631	3-hydroxy-3-methylglutaryl-coenzyme A reductase	HMGCR	0.0098
3387	3-hydroxy-3-methylglutaryl-coenzyme A reductase	mvaA	0.0098
478	Voltage-dependent L-type calcium channel subunit alpha-1C	CACNA1C	0.0098
450	Muscarinic acetylcholine receptor M4	CHRM4	0.0098
4116	Dihydropteroate synthetase	Not Available	0.0097
614	Progesterone receptor	PGR	0.0096
766	Beta-2 adrenergic receptor	ADRB2	0.0095
385	Potassium-transporting ATPase alpha chain 1	ATP4A	0.0092
3941	Amine oxidase [flavin-containing] A	MAOA	0.0092
4111	Voltage-dependent L-type calcium channel subunit alpha-1S	CACNA1S	0.009
621	Periplasmic [Fe] hydrogenase 1	Not Available	0.0088
4110	Voltage-dependent L-type calcium channel subunit beta-2	CACNB2	0.0085
6102	Arylamine N-acetyltransferase 2	NAT2	0.0084
6101	Dimethylaniline monooxygenase [N-oxide-forming] 3	FMO3	0.0082
29	Tubulin beta-1 chain	TUBB1	0.0081
204	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE5A	0.0081
232	Corticosteroid-binding globulin	SERPINA6	0.008
465	Calmodulin	CALM1	0.008
6147	Solute carrier family 22 member 3	SLC22A3	0.0079
1284	Nuclear receptor subfamily 1 group I member 2	NR1I2	0.0078
530	Gamma-aminobutyric-acid receptor subunit alpha-4	GABRA4	0.0078
365	Dihydrofolate reductase	DHFR	0.0077
2381	Dihydrofolate reductase	DFR1	0.0077
2833	Dihydrofolate reductase	Not Available	0.0077
2931	Dihydrofolate reductase	folA	0.0077
3544	Dihydrofolate reductase	folA	0.0077
3682	Dihydrofolate reductase	folA	0.0077
6642	Dihydrofolate reductase	folA	0.0077
6756	Dihydrofolate reductase	dfrA	0.0077
841	Gamma-aminobutyric-acid receptor subunit alpha-6	GABRA6	0.0077
15	Voltage-dependent T-type calcium channel subunit alpha-1I	CACNA1I	0.0076
6141	Sodium/bile acid cotransporter	SLC10A1	0.0075
706	Glutamate [NMDA] receptor subunit 3A	GRIN3A	0.0075
778	Cysteinyl leukotriene receptor 1	CYSLTR1	0.0075
504	Mast/stem cell growth factor receptor	KIT	0.0074
6136	Multidrug resistance-associated protein 5	ABCC5	0.0073
762	Voltage-dependent calcium channel subunit alpha-2/delta-1	CACNA2D1	0.0073
3939	Amine oxidase [flavin-containing] B	MAOB	0.0072
2183	Fatty acid-binding protein, adipocyte	FABP4	0.0072
789	Alpha-1D adrenergic receptor	ADRA1D	0.0072
535	Voltage-dependent T-type calcium channel subunit alpha-1G	CACNA1G	0.0072
6177	UDP-glucuronosyltransferase 1-10	UGT1A10	0.007
4100	Gamma-aminobutyric-acid receptor subunit beta-2	GABRB2	0.0069
49	Endothelin B receptor	EDNRB	0.0069
4099	Gamma-aminobutyric-acid receptor subunit beta-3	GABRB3	0.0068
844	Epidermal growth factor receptor	EGFR	0.0068
817	DNA topoisomerase 2-alpha	TOP2A	0.0068
620	Bifunctional dihydrofolate reductase-thymidylate synthase	Not Available	0.0068
869	Estrogen receptor beta	ESR2	0.0068
295	Carbonic anhydrase 1	CA1	0.0068
952	Dipeptidyl peptidase 4	DPP4	0.0067
885	5-hydroxytryptamine 1B receptor	HTR1B	0.0067
407	Vascular endothelial growth factor receptor 2	KDR	0.0067
592	Carbonic anhydrase 4	CA4	0.0067
6086	Gamma-aminobutyric acid receptor subunit gamma-2	GABRG2	0.0066
4604	Liver carboxylesterase 1	CES1	0.0066
6137	Multidrug resistance-associated protein 6	ABCC6	0.0066
578	Endothelin-1 receptor	EDNRA	0.0065
380	Cytochrome P450 17A1	CYP17A1	0.0065
833	Organic cation/carnitine transporter 1	SLC22A4	0.0064
964	Voltage-dependent T-type calcium channel subunit alpha-1H	CACNA1H	0.0064
4177	Proto-oncogene tyrosine-protein kinase receptor ret	RET	0.0063
133	Dihydropterate synthase	sulI	0.0063
638	D(3) dopamine receptor	DRD3	0.0063
6148	Multidrug resistance-associated protein 7	ABCC10	0.0062
629	Alpha-2B adrenergic receptor	ADRA2B	0.0062
990	Dual specificity mitogen-activated protein kinase kinase 1	MAP2K1	0.0062
6104	Dimethylaniline monooxygenase [N-oxide-forming] 1	FMO1	0.0061
198	Sodium channel protein type 10 subunit alpha	SCN10A	0.0061
6087	Gamma-aminobutyric acid receptor subunit gamma-1	GABRG1	0.006
6093	Gamma-aminobutyric acid receptor subunit delta	GABRD	0.006
6089	Gamma-aminobutyric acid receptor subunit epsilon	GABRE	0.006
725	5-hydroxytryptamine 1D receptor	HTR1D	0.006
6085	Fatty acid-binding protein, intestinal	FABP2	0.006
756	Sex hormone-binding globulin	SHBG	0.0059
4148	Serine/threonine-protein kinase mTOR	MTOR	0.0059
3923	Cholinesterase	BCHE	0.0058
4098	Gamma-aminobutyric-acid receptor subunit beta-1	GABRB1	0.0058
3810	Catechol O-methyltransferase	COMT	0.0058
818	50S ribosomal protein L10	rplJ	0.0058
275	Arachidonate 5-lipoxygenase	ALOX5	0.0058
606	Cytochrome P450 27, mitochondrial	CYP27A1	0.0058
88	Retinoic acid receptor RXR-beta	RXRB	0.0057
6181	UDP-glucuronosyltransferase 1-8	UGT1A8	0.0057
6088	Gamma-aminobutyric acid receptor subunit gamma-3	GABRG3	0.0057
6090	Gamma-aminobutyric acid receptor subunit pi	GABRP	0.0057
6092	Gamma-aminobutyric acid receptor subunit rho-2	GABRR2	0.0056
6115	Gamma-aminobutyric acid receptor subunit rho-3	GABRR3	0.0056
427	Substance-P receptor	TACR1	0.0056
6158	Solute carrier organic anion transporter family member 1C1	SLCO1C1	0.0056
777	Tumor necrosis factor	TNF	0.0056
1539	Oligopeptide transporter, small intestine isoform	SLC15A1	0.0056
142	Gamma-aminobutyric-acid receptor subunit rho-1	GABRR1	0.0056
24	Thymidylate synthase	TMP1	0.0055
359	Thymidylate synthase	TYMS	0.0055
2626	Thymidylate synthase	thyA	0.0055
2729	Thymidylate synthase	thyA	0.0055
5352	Thymidylate synthase	THYA	0.0055
4120	NADPH--cytochrome P450 reductase	POR	0.0055
737	Mineralocorticoid receptor	NR3C2	0.0054
781	ATP-sensitive inward rectifier potassium channel 11	KCNJ11	0.0054
947	Neuronal acetylcholine receptor subunit alpha-4	CHRNA4	0.0053
4095	Neuronal acetylcholine receptor subunit alpha-7	CHRNA7	0.0053
94	5-hydroxytryptamine 4 receptor	HTR4	0.0053
161	Tubulin beta chain	TUBB	0.0052
312	Tubulin beta chain	TUB2	0.0052
193	Beta-1 adrenergic receptor	ADRB1	0.0052
66	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II	HSD3B2	0.0051
436	5-hydroxytryptamine 2B receptor	HTR2B	0.0051
4203	Histamine N-methyltransferase	HNMT	0.0051
17	Proto-oncogene tyrosine-protein kinase ABL1	ABL1	0.0051
1757	Myeloperoxidase	MPO	0.0051
147	Aldehyde dehydrogenase, mitochondrial	ALDH2	0.0051
378	Alpha-2C adrenergic receptor	ADRA2C	0.005
650	Aldo-keto reductase family 1 member C3	AKR1C3	0.005
357	Carbonic anhydrase 2	CA2	0.005
6025	UDP-glucuronosyltransferase 1-4	UGT1A4	0.0049
3804	Sodium channel protein type 4 subunit alpha	SCN4A	0.0049
1010	Cytochrome P450 51A1	CYP51A1	0.0049
856	Vitamin D3 receptor	VDR	0.0049
814	Ryanodine receptor 1	RYR1	0.0048
6020	Aldehyde oxidase	AOX1	0.0048
6220	Aryl hydrocarbon receptor	AHR	0.0047
567	Receptor tyrosine-protein kinase erbB-2	ERBB2	0.0047
373	Transthyretin	TTR	0.0046
1648	Elastin	ELN	0.0046
6091	Gamma-aminobutyric acid receptor subunit theta	GABRQ	0.0046
6014	Cytochrome P450 2A13	CYP2A13	0.0046
68	Cannabinoid receptor 1	CNR1	0.0046
26	Vascular endothelial growth factor receptor 3	FLT4	0.0046
6180	UDP-glucuronosyltransferase 2B4	UGT2B4	0.0046
527	Prostacyclin receptor	PTGIR	0.0045
158	Sodium channel protein type 1 subunit alpha	SCN1A	0.0045
1275	Estrogen sulfotransferase	SULT1E1	0.0045
40	RAF proto-oncogene serine/threonine-protein kinase	RAF1	0.0045
228	Beta platelet-derived growth factor receptor	PDGFRB	0.0045
474	Acetylcholinesterase	ACHE	0.0045
698	B-Raf proto-oncogene serine/threonine-protein kinase	BRAF	0.0045
208	DNA-directed RNA polymerase beta' chain	rpoC	0.0044
5774	DNA-directed RNA polymerase beta' chain	rpoC	0.0044
432	D(4) dopamine receptor	DRD4	0.0044
130	Prostacyclin synthase	PTGIS	0.0044
32	Vascular endothelial growth factor receptor 1	FLT1	0.0044
1050	Bile salt sulfotransferase	SULT2A1	0.0044
1974	Oligopeptide transporter, kidney isoform	SLC15A2	0.0044
918	Glutamate receptor, ionotropic kainate 2	GRIK2	0.0043
709	ATP-sensitive inward rectifier potassium channel 1	KCNJ1	0.0043
750	Voltage-dependent calcium channel gamma-1 subunit	CACNG1	0.0043
462	Intermediate conductance calcium-activated potassium channel protein 4	KCNN4	0.0042
6045	Voltage-dependent calcium channel subunit alpha-2/delta-3	CACNA2D3	0.0042
950	Alpha platelet-derived growth factor receptor	PDGFRA	0.0042
738	Monocarboxylate transporter 1	SLC16A1	0.0042
716	5-hydroxytryptamine 7 receptor	HTR7	0.0041
1995	Sodium channel protein type 9 subunit alpha	SCN9A	0.0041
4160	Voltage-dependent calcium channel subunit alpha-2/delta-2	CACNA2D2	0.0041
6068	Guanylate cyclase soluble subunit alpha-2	GUCY1A2	0.0041
3997	Cytochrome P450 24A1, mitochondrial	CYP24A1	0.0041
1629	Transcription factor AP-1	JUN	0.004
6079	Neuronal acetylcholine receptor subunit alpha-3	CHRNA3	0.004
921	Glutamate receptor 2	GRIA2	0.004
780	Retinoic acid receptor RXR-gamma	RXRG	0.0039
6138	Multidrug resistance protein 3	ABCB4	0.0039
1129	C-C chemokine receptor type 5	CCR5	0.0039
571	Melatonin receptor type 1A	MTNR1A	0.0038
362	Melatonin receptor type 1B	MTNR1B	0.0038
6126	Carbonic anhydrase 7	CA7	0.0038
6103	Arylamine N-acetyltransferase 1	NAT1	0.0037
284	DNA-directed RNA polymerase beta chain	rpoB	0.0037
5773	DNA-directed RNA polymerase beta chain	rpoB	0.0037
54	Prothrombin	F2	0.0037
4122	Histone deacetylase 2	HDAC2	0.0037
1656	CYP2B protein	CYP2B	0.0036
482	Glycine receptor subunit alpha-1	GLRA1	0.0036
558	Solute carrier family 12 member 1	SLC12A1	0.0036
2222	Equilibrative nucleoside transporter 1	SLC29A1	0.0036
16	Adenosine A1 receptor	ADORA1	0.0036
4237	50S ribosomal protein L22	rplV	0.0035
185	Vasopressin V1a receptor	AVPR1A	0.0035
2539	Tubulin alpha-1 chain	TUBA4A	0.0035
518	Peroxidase/catalase T	katG	0.0035
1178	Adenosine A2a receptor	ADORA2A	0.0035
939	50S ribosomal protein L3	rplC	0.0035
485	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	PDE3A	0.0035
124	Histamine H2 receptor	HRH2	0.0034
322	Vasopressin V2 receptor	AVPR2	0.0034
4113	Voltage-dependent L-type calcium channel subunit alpha-1F	CACNA1F	0.0034
1483	Membrane copper amine oxidase	AOC3	0.0034
5300	Antigen peptide transporter 1	TAP1	0.0034
581	Cytochrome P450 2R1	CYP2R1	0.0034
6043	Putative G-protein coupled receptor 44	GPR44	0.0033
6150	Solute carrier organic anion transporter family member 4C1	SLCO4C1	0.0033
596	3-oxo-5-alpha-steroid 4-dehydrogenase 1	SRD5A1	0.0033
1457	Long-chain-fatty-acid--CoA ligase 4	ACSL4	0.0033
6023	Cytochrome P450 11B2, mitochondrial	CYP11B2	0.0033
183	Vascular endothelial growth factor A	VEGFA	0.0033
6040	6-phosphogluconate dehydrogenase, decarboxylating	PGD	0.0033
5880	Thrombopoietin receptor	MPL	0.0033
162	Retinoic acid receptor gamma-1	RARG	0.0032
137	FolC bifunctional protein [Includes: Folylpolyglutamate synthase	folC	0.0032
459	Retinoic acid receptor RXR-alpha	RXRA	0.0032
6174	50S ribosomal protein L32	rpmF	0.0032
3947	Xanthine dehydrogenase/oxidase	XDH	0.0032
140	30S ribosomal protein S9	rpsI	0.0031
6719	30S ribosomal protein S9	rpsI	0.0031
6725	30S ribosomal protein S9	rpsI	0.0031
276	Sodium- and chloride-dependent GABA transporter 1	SLC6A1	0.0031
1196	Complement decay-accelerating factor	CD55	0.0031
3809	Estrogen-related receptor gamma	ESRRG	0.0031
1787	Nuclear factor NF-kappa-B p105 subunit	NFKB1	0.0031
3086	Plasmepsin-2	Not Available	0.0031
1227	Cytochrome b	MT-CYB	0.0031
6386	Cytochrome b	petB	0.0031
6937	Cytochrome b	MT-CYB	0.0031
674	Dihydroorotate dehydrogenase homolog, mitochondrial	PFF0160c	0.0031
858	Potassium voltage-gated channel subfamily A member 1	KCNA1	0.003
705	Glutamate receptor 1	GRIA1	0.003
2578	Tubulin beta-3 chain	TUBB3	0.003
3854	Basic fibroblast growth factor receptor 1	FGFR1	0.003
2285	Streptogramin A acetyltransferase	vatD	0.003
823	Fibroblast growth factor receptor 2	FGFR2	0.003
153	Dopamine beta-hydroxylase	DBH	0.0029
424	Dihydroorotate dehydrogenase, mitochondrial	DHODH	0.0029
6153	Solute carrier organic anion transporter family member 4A1	SLCO4A1	0.0029
634	Squalene monooxygenase	SQLE	0.0028
7196	Squalene monooxygenase	ERG1	0.0028
1618	High affinity nerve growth factor receptor	NTRK1	0.0028
1200	AMBP protein	AMBP	0.0028
3866	Serum amyloid A protein	SAA1	0.0028
1932	Apolipoprotein E	APOE	0.0028
1852	Microtubule-associated protein 2	MAP2	0.0028
723	Cytosolic phospholipase A2	PLA2G4A	0.0027
139	Aldo-keto reductase family 1 member C1	AKR1C1	0.0027
2808	Chloramphenicol acetyltransferase 3	cat3	0.0027
1144	Hepatocyte growth factor receptor	MET	0.0027
458	Neuronal acetylcholine receptor subunit alpha-10	CHRNA10	0.0027
4173	Tyrosine-protein kinase JAK2	JAK2	0.0027
84	Nuclear receptor 0B1	NR0B1	0.0027
5787	Angiopoietin-1 receptor	TEK	0.0027
2159	Quinone oxidoreductase	CRYZ	0.0027
6047	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	PDE1A	0.0027
1192	Sulfotransferase 1A1	SULT1A1	0.0027
469	Annexin A1	ANXA1	0.0027
239	Coagulation factor X	F10	0.0027
163	D(1B) dopamine receptor	DRD5	0.0027
2184	Cystic fibrosis transmembrane conductance regulator	CFTR	0.0026
273	Apoptosis regulator Bcl-2	BCL2	0.0026
515	26S proteasome non-ATPase regulatory subunit 1	PSMD1	0.0026
522	26S proteasome non-ATPase regulatory subunit 2	PSMD2	0.0026
3856	Fibroblast growth factor receptor 3	FGFR3	0.0026
5692	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	PDE1B	0.0026
2180	3-phosphoinositide-dependent protein kinase 1	PDPK1	0.0026
3639	Thymidine phosphorylase	deoA	0.0025
3936	Thymidine phosphorylase	TYMP	0.0025
165	FL cytokine receptor	FLT3	0.0025
528	5-hydroxytryptamine 1E receptor	HTR1E	0.0025
6033	High affinity interleukin-8 receptor A	CXCR1	0.0025
2417	Chloramphenicol acetyltransferase	cat	0.0025
3278	Chloramphenicol acetyltransferase	cat	0.0025
3808	Dihydropteroate synthase 2	folP2	0.0025
3601	Dihydropteroate synthase 1	folP1	0.0025
3807	Dihydropteroate synthase 1	folP1	0.0025
768	FK506-binding protein 1A	FKBP1A	0.0025
2810	Dr hemagglutinin structural subunit	draA	0.0025
2718	Chloramphenicol 3-O phosphotransferase	Not Available	0.0025
6038	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6H	0.0024
6179	UDP-glucuronosyltransferase 2B17	UGT2B17	0.0024
1256	5-hydroxytryptamine 6 receptor	HTR6	0.0024
1302	Dihydropyrimidine dehydrogenase [NADP+]	DPYD	0.0024
544	Potassium voltage-gated channel subfamily E member 1	KCNE1	0.0024
541	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	PDE4B	0.0024
6039	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	PDE11A	0.0024
2112	Toll-like receptor 9	TLR9	0.0024
229	Retinoic acid receptor beta	RARB	0.0024
5852	Type-2 angiotensin II receptor	AGTR2	0.0024
392	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	CACNA1A	0.0024
642	3-oxo-5-alpha-steroid 4-dehydrogenase 2	SRD5A2	0.0023
215	Sodium channel protein type 11 subunit alpha	SCN11A	0.0023
730	Retinoic acid receptor alpha	RARA	0.0023
6037	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6G	0.0023
6146	High affinity copper uptake protein 1	SLC31A1	0.0023
813	Neuronal acetylcholine receptor subunit alpha-2	CHRNA2	0.0022
2157	NAD(P)H dehydrogenase [quinone] 1	NQO1	0.0022
2981	Phospholipase A2, membrane associated	PLA2G2A	0.0022
4311	tRNA	TRDMT1	0.0022
4325	tRNA	trmD	0.0022
4328	tRNA	trmD	0.0022
4209	ATP-sensitive inward rectifier potassium channel 8	KCNJ8	0.0022
1992	Vitamin D-binding protein	GC	0.0022
164	Histamine H4 receptor	HRH4	0.0022
319	Opioid receptor, sigma 1	OPRS1	0.0022
259	Microsomal triglyceride transfer protein large subunit	MTTP	0.0022
368	Enoyl-[acyl-carrier-protein] reductase [NADH]	inhA	0.0022
3228	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0022
3678	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0022
6856	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0022
2232	Interleukin-5	IL5	0.0022
2449	Tubulin alpha-3 chain	TUBA1A	0.0021
298	Renin	REN	0.0021
1593	Mucin-2	MUC2	0.0021
6506	Stathmin-4	STMN4	0.0021
6149	Solute carrier family 22 member 10	SLC22A10	0.0021
6078	Neuronal acetylcholine receptor subunit beta-4	CHRNB4	0.0021
464	Glutamate [NMDA] receptor subunit epsilon-2	GRIN2B	0.0021
741	Potassium voltage-gated channel subfamily KQT member 1	KCNQ1	0.0021
976	Platelet glycoprotein IX	GP9	0.0021
1630	Integrin beta-2	ITGB2	0.0021
4103	Proteasome subunit beta type 2	PSMB2	0.0021
4102	Proteasome subunit beta type 5	PSMB5	0.0021
4101	Proteasome subunit beta type 1	PSMB1	0.0021
1971	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	PDE4A	0.0021
594	Thyroxine-binding globulin	SERPINA7	0.002
3611	Cytidine deaminase	cdd	0.002
3707	Cytidine deaminase	cdd	0.002
4211	Cytidine deaminase	CDA	0.002
6206	DNA-directed RNA polymerase subunit beta'	rpoC	0.002
280	4-aminobutyrate aminotransferase, mitochondrial	ABAT	0.002
3970	Voltage-dependent N-type calcium channel subunit alpha-1B	CACNA1B	0.002
4217	Telomerase reverse transcriptase	TERT	0.002
904	Glutathione S-transferase P	GSTP1	0.002
4199	Sphingosine 1-phosphate receptor Edg-8	S1PR5	0.002
6154	Multidrug and toxin extrusion protein 1	SLC47A1	0.0019
633	Penicillin-binding proteins 1A/1B	pbpA	0.0019
241	Calcium-transporting ATPase type 2C member 1	ATP2C1	0.0019
5923	Microtubule-associated protein tau	MAPT	0.0019
5924	Microtubule-associated protein 4	MAP4	0.0019
1291	cAMP response element-binding protein	CREB1	0.0019
2499	Tubulin beta-2C chain	TUBB2C	0.0019
233	Potassium channel subfamily K member 2	KCNK2	0.0019
1086	Potassium voltage-gated channel subfamily KQT member 2	KCNQ2	0.0019
758	Thyroid hormone receptor alpha	THRA	0.0019
477	DNA topoisomerase 4 subunit A	parC	0.0019
886	DNA topoisomerase 4 subunit A	parC	0.0019
6226	DNA topoisomerase 4 subunit A	parC	0.0019
6046	Voltage-gated calcium channel beta 1 subunit splice variant CavB1d	CACNB1	0.0018
174	Sigma 1-type opioid receptor	SIGMAR1	0.0018
404	DNA gyrase subunit A	gyrA	0.0018
6224	DNA gyrase subunit A	gyrA	0.0018
537	ATP synthase delta chain, mitochondrial	ATP5D	0.0018
4210	Toll-like receptor 4	TLR4	0.0018
5998	Toll-like receptor 8	TLR8	0.0018
1262	Corticotropin-lipotropin	POMC	0.0018
4238	50S ribosomal protein L4	rplD	0.0018
5578	50S ribosomal protein L4	rplD	0.0018
6173	50S ribosomal protein L4	rplD	0.0018
6219	50S ribosomal protein L4	rplD	0.0018
712	Tubulin alpha chain	TUB1	0.0018
1968	ATP-sensitive inward rectifier potassium channel 12	KCNJ12	0.0018
565	Extracellular calcium-sensing receptor	CASR	0.0018
6048	Troponin C, skeletal muscle	TNNC2	0.0018
683	Potassium transporter	GK0582	0.0018
1123	Eosinophil cationic protein	RNASE3	0.0018
6152	Solute carrier organic anion transporter family member 2A1	SLCO2A1	0.0018
199	Monocarboxylate transporter 8	SLC16A2	0.0018
559	NADH-ubiquinone oxidoreductase chain 1	MT-ND1	0.0017
67	Prolyl 4-hydroxylase subunit alpha-1	P4HA1	0.0017
613	Atrial natriuretic peptide receptor A	NPR1	0.0017
719	Retinoic acid receptor responder protein 1	RARRES1	0.0017
770	Retinoic acid-induced protein 3	GPRC5A	0.0017
268	Adenosine A2b receptor	ADORA2B	0.0017
543	Penicillin-binding protein 1B	mrcB	0.0017
6186	Penicillin-binding protein 1B	ponB	0.0017
6822	Penicillin-binding protein 1b	pbp1b	0.0017
6844	Penicillin-binding protein 1b	pbp1b	0.0017
837	Glutamate [NMDA] receptor subunit epsilon-1	GRIN2A	0.0017
4112	Voltage-dependent L-type calcium channel subunit beta-4	CACNB4	0.0017
4114	Voltage-dependent L-type calcium channel subunit beta-3	CACNB3	0.0017
106	Cannabinoid receptor 2	CNR2	0.0017
6044	Serum paraoxonase/lactonase 3	PON3	0.0017
6824	Tyrosine-protein kinase Lyn	LYN	0.0017
4773	Deoxycytidine kinase	DCK	0.0017
159	Penicillin-binding protein 2B	penA	0.0017
6121	Penicillin-binding protein 2B	penA	0.0017
992	Protein tyrosine kinase 2 beta	PTK2B	0.0017
3937	Fatty-acid amide hydrolase	FAAH	0.0017
346	Thyroid hormone receptor beta-1	THRB	0.0017
610	Calcium-activated potassium channel subunit alpha 1	KCNMA1	0.0016
6099	Potassium voltage-gated channel subfamily D member 3	KCND3	0.0016
6098	Potassium voltage-gated channel subfamily D member 2	KCND2	0.0016
3802	Sodium channel protein type 2 subunit alpha	SCN2A	0.0016
4226	Uridine phosphorylase 2	UPP2	0.0016
102	DNA topoisomerase I, mitochondrial	TOP1MT	0.0016
563	Thyroid peroxidase	TPO	0.0016
243	Ribosyldihydronicotinamide dehydrogenase [quinone]	NQO2	0.0016
572	Integrin alpha-L	ITGAL	0.0016
173	Toll-like receptor 7	TLR7	0.0016
3868	Calcineurin subunit B isoform 2	PPP3R2	0.0016
421	Calcium signal-modulating cyclophilin ligand	CAMLG	0.0016
5798	Mitogen-activated protein kinase 11	MAPK11	0.0016
3913	Glutamic acid decarboxylase	GAD65	0.0016
333	Voltage-dependent L-type calcium channel subunit beta-1	CACNB1	0.0016
3233	Bile acid receptor	NR1H4	0.0015
6080	Neuronal acetylcholine receptor subunit alpha-5	CHRNA5	0.0015
6082	Neuronal acetylcholine receptor subunit beta-3	CHRNB3	0.0015
2320	Thymidine kinase, cytosolic	TK1	0.0015
948	Neuronal acetylcholine receptor subunit beta-2	CHRNB2	0.0015
936	Ephrin type-A receptor 2	EPHA2	0.0015
2853	14 kDa fatty acid-binding protein	Not Available	0.0015
569	Retinal dehydrogenase 2	ALDH1A2	0.0015
267	Plasminogen activator inhibitor 1	SERPINE1	0.0015
4225	Uridine phosphorylase 1	UPP1	0.0015
489	Monocarboxylate transporter 2	SLC16A7	0.0014
1341	Histamine H3 receptor	HRH3	0.0014
611	Retinal dehydrogenase 1	ALDH1A1	0.0014
6155	ATP-binding cassette transporter sub-family C member 11	ABCC11	0.0014
6081	Neuronal acetylcholine receptor subunit alpha-6	CHRNA6	0.0014
4097	Neuronal acetylcholine receptor subunit alpha-9	CHRNA9	0.0014
7	Nitric oxide synthase, inducible	NOS2	0.0014
2599	Tyrosine-protein kinase HCK	HCK	0.0014
6032	PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE)	fas	0.0014
564	Cellular retinoic acid-binding protein 1	CRABP1	0.0014
6221	Steroid hormone receptor ERR1	ESRRA	0.0014
6218	Pannexin-1	PANX1	0.0014
413	Amidophosphoribosyltransferase	PPAT	0.0014
2515	Amidophosphoribosyltransferase	purF	0.0014
3714	Amidophosphoribosyltransferase	purF	0.0014
5934	Cytochrome P450 26A1	CYP26A1	0.0014
751	Potassium channel subfamily K member 6	KCNK6	0.0013
1039	Histone deacetylase 9	HDAC9	0.0013
859	Cellular retinoic acid-binding protein 2	CRABP2	0.0013
2021	Thrombomodulin	THBD	0.0013
2450	Tyrosine-protein kinase ITK/TSK	ITK	0.0013
2216	Fibroblast growth factor receptor 4	FGFR4	0.0013
1353	DNA topoisomerase 1	TOP1	0.0013
3552	DNA topoisomerase 1	topA	0.0013
1561	Troponin C, slow skeletal and cardiac muscles	TNNC1	0.0013
735	Alanine aminotransferase 1	GPT	0.0013
3904	Alanine aminotransferase 2	GPT2	0.0013
6123	Carbonic anhydrase 5A, mitochondrial	CA5A	0.0013
2207	Rhodopsin	RHO	0.0013
908	Glutathione S-transferase theta-1	GSTT1	0.0013
6116	Gastric triacylglycerol lipase	LIPF	0.0012
4192	DNA topoisomerase 2-beta	TOP2B	0.0012
172	Potassium channel subfamily K member 1	KCNK1	0.0012
3806	cGMP-dependent 3',5'-cyclic phosphodiesterase	PDE2A	0.0012
3823	Cytokine receptor common gamma chain	IL2RG	0.0012
85	Growth hormone receptor	GHR	0.0012
2107	Microtubule-associated protein 1A	MAP1A	0.0012
1524	Peptidyl-prolyl cis-trans isomerase A	PPIA	0.0012
6700	Peptidyl-prolyl cis-trans isomerase A	ppiA	0.0012
338	DNA polymerase	UL30	0.0012
379	DNA polymerase	UL54	0.0012
697	DNA polymerase	ORF28	0.0012
2482	DNA polymerase	43	0.0012
4104	DNA polymerase	BALF5	0.0012
200	Carnitine O-palmitoyltransferase 2, mitochondrial	CPT2	0.0012
451	Carnitine O-palmitoyltransferase I, liver isoform	CPT1A	0.0012
1295	Fatty acid synthase	FASN	0.0012
933	Proto-oncogene tyrosine-protein kinase Src	SRC	0.0012
605	Fumarate reductase flavoprotein subunit	frdA	0.0012
2709	Fumarate reductase flavoprotein subunit	SO_0970	0.0012
3673	Fumarate reductase flavoprotein subunit	fccA	0.0012
4912	Fumarate reductase flavoprotein subunit	ifcA	0.0012
6549	Fumarate reductase flavoprotein subunit	frdA	0.0012
5433	UPF0230 protein TM_1468	TM_1468	0.0012
5431	Lipid binding protein	Not Available	0.0012
3616	Fatty acid-binding protein, epidermal	FABP5	0.0012
5430	Hepatocyte nuclear factor 4-gamma	HNF4G	0.0012
182	2-oxoglutarate dehydrogenase E1 component, mitochondrial	OGDH	0.0012
630	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial	ACADSB	0.0012
3957	Adenosine deaminase	ADA	0.0011
6100	BDNF/NT-3 growth factors receptor	NTRK2	0.0011
389	Amiloride-sensitive cation channel 2, neuronal	ACCN2	0.0011
754	Pancreatic triacylglycerol lipase	PNLIP	0.0011
6140	Ileal sodium/bile acid cotransporter	SLC10A2	0.0011
4162	Potassium voltage-gated channel subfamily KQT member 3	KCNQ3	0.0011
1374	Natriuretic peptides B	NPPB	0.0011
1827	Gap junction alpha-1 protein	GJA1	0.0011
1908	Vascular cell adhesion protein 1	VCAM1	0.0011
896	Glutathione S-transferase Mu 1	GSTM1	0.0011
591	Glutamate [NMDA] receptor subunit 3B	GRIN3B	0.0011
2178	Metabotropic glutamate receptor 5	GRM5	0.0011
724	Interleukin-2 receptor alpha chain	IL2RA	0.0011
717	Interleukin-2 receptor subunit beta	IL2RB	0.0011
3917	Methylenetetrahydrofolate reductase	MTHFR	0.001
1810	Protein S100-A1	S100A1	0.001
6097	Protein S100-A2	S100A2	0.001
245	Large neutral amino acids transporter small subunit 1	SLC7A5	0.001
4228	Keratin, type II cytoskeletal 7	KRT7	0.001
838	Inosine-5'-monophosphate dehydrogenase 1	IMPDH1	0.001
796	Inosine-5'-monophosphate dehydrogenase 2	IMPDH2	0.001
5251	Carbonyl reductase [NADPH] 1	CBR1	0.001
511	5-hydroxytryptamine 1F receptor	HTR1F	0.001
170	Succinate semialdehyde dehydrogenase, mitochondrial	ALDH5A1	0.001
493	25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	CYP27B1	0.001
951	Macrophage colony-stimulating factor 1 receptor	CSF1R	0.001
695	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	PDE10A	0.001
283	SEC14-like protein 2	SEC14L2	0.001
439	Glutamate [NMDA] receptor subunit epsilon-4	GRIN2D	0.001
512	DNA-directed RNA polymerase alpha chain	rpoA	0.001
5772	DNA-directed RNA polymerase alpha chain	rpoA	0.001
937	Proto-oncogene tyrosine-protein kinase LCK	LCK	0.001
4041	Microsomal glutathione S-transferase 2	MGST2	0.001
251	Alcohol dehydrogenase 1A	ADH1A	0.001
6837	Serine/threonine-protein kinase 17B	STK17B	0.001
6836	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial	HIBCH	0.001
4948	Cytochrome c-553	Not Available	0.001
4923	Cytochrome c3	DvMF_2499	0.001
4945	Cytochrome c3	Not Available	0.001
4949	Cytochrome c3	DVU_3171	0.001
4968	Cytochrome c3	cytc3	0.001
4997	Cytochrome c3	SO_2727	0.001
5219	Cytochrome c3	cyd	0.001
4902	Nine-heme cytochrome c	Ddes_2038	0.001
3189	High-molecular-weight cytochrome c	hmcA	0.001
760	Fibroblast growth factor 1	FGF1	0.001
2268	Cholesterol oxidase	choB	0.0009
2822	Cholesterol oxidase	choA	0.0009
5432	Trafficking protein particle complex subunit 3	TRAPPC3	0.0009
2211	Fatty acid-binding protein, heart	FABP3	0.0009
6459	Glycodelin	PAEP	0.0009
1517	Beta-3 adrenergic receptor	ADRB3	0.0009
820	Glycine receptor subunit alpha-2	GLRA2	0.0009
6105	3-oxo-5-beta-steroid 4-dehydrogenase	AKR1D1	0.0009
194	NADH dehydrogenase [ubiquinone] 1 subunit C2	NDUFC2	0.0009
1792	Tissue-type plasminogen activator	PLAT	0.0009
828	Phenylalanine-4-hydroxylase	PAH	0.0009
3109	Phenylalanine-4-hydroxylase	phhA	0.0009
1048	Protein S100-A13	S100A13	0.0009
401	Glutamate [NMDA] receptor subunit zeta-1	GRIN1	0.0009
2226	Protein S100-A12	S100A12	0.0009
1759	85 kDa calcium-independent phospholipase A2	PLA2G6	0.0009
1770	Phospholipase C	PLCL1	0.0009
2841	Phospholipase C	plc	0.0009
806	Sodium/potassium-transporting ATPase alpha-1 chain	ATP1A1	0.0009
6677	Myelin P2 protein	PMP2	0.0009
6131	Carbonic anhydrase 14	CA14	0.0009
2283	Steroid Delta-isomerase	ksi	0.0009
2920	Steroid Delta-isomerase	ksi	0.0009
33	Cystine/glutamate transporter	SLC7A11	0.0009
444	Alcohol dehydrogenase 1B	ADH1B	0.0009
390	Adenosine A3 receptor	ADORA3	0.0009
6169	ATP-binding cassette sub-family A member 5	ABCA5	0.0009
2132	Protein S100-B	S100B	0.0009
382	Glutamate receptor, ionotropic kainate 1	GRIK1	0.0008
3961	G protein-activated inward rectifier potassium channel 4	KCNJ5	0.0008
3404	Exotoxin A	eta	0.0008
6656	UDP-glucuronosyltransferase 3A1	UGT3A1	0.0008
2298	Cytochrome P450-cam	camC	0.0008
22	30S ribosomal protein S4	rpsD	0.0008
6714	30S ribosomal protein S4	rpsD	0.0008
6122	Carbonic anhydrase 3	CA3	0.0008
2325	Sulfotransferase family cytosolic 2B member 1	SULT2B1	0.0008
4386	Hemoglobin-like protein HbN	glbN	0.0008
73	Prostaglandin E2 receptor, EP1 subtype	PTGER1	0.0008
1864	RET proto-oncogene	RET	0.0008
1950	Epithelial discoidin domain-containing receptor 1	DDR1	0.0008
6170	ATP-binding cassette sub-family A member 3	ABCA3	0.0008
6094	BCR/ABL fusion protein isoform X9	BCR/ABL fusion	0.0008
1867	Major prion protein	PRNP	0.0008
4031	Glutathione S-transferase A1	GSTA1	0.0008
6599	HTH-type transcriptional regulator ttgR	ttgR	0.0008
6432	Transporter	snf	0.0008
1649	Small inducible cytokine A2	CCL2	0.0008
734	D1 dopamine receptor-interacting protein calcyon	CALY	0.0008
1025	Aquaporin-1	AQP1	0.0008
1768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit	GNG2	0.0008
1268	Neuropeptide S receptor	NPSR1	0.0008
1571	G protein-activated inward rectifier potassium channel 1	KCNJ3	0.0008
1581	G protein-activated inward rectifier potassium channel 2	KCNJ6	0.0008
517	Alcohol dehydrogenase 1C	ADH1C	0.0008
5766	NAD-dependent deacetylase sirtuin-5	SIRT5	0.0008
3830	Calreticulin	CALR	0.0008
6931	Calcium-activated potassium channel subunit beta-1	KCNMB1	0.0008
6932	Calcium-activated potassium channel subunit beta-3	KCNMB3	0.0008
6933	Calcium-activated potassium channel subunit beta-4	KCNMB4	0.0008
2091	Endoplasmin	HSP90B1	0.0008
6934	Small conductance calcium-activated potassium channel protein 1	KCNN1	0.0008
6935	Small conductance calcium-activated potassium channel protein 2	KCNN2	0.0008
6936	Small conductance calcium-activated potassium channel protein 3	KCNN3	0.0008
6893	Calcium/calmodulin-dependent protein kinase type II gamma chain	CAMK2G	0.0007
3221	Cytochrome c4	cc4	0.0007
473	L-lactate dehydrogenase A chain	LDHA	0.0007
461	Glycine receptor subunit alpha-3	GLRA3	0.0007
521	ATP-binding cassette transporter sub-family C member 9	ABCC9	0.0007
217	Estradiol 17-beta-dehydrogenase 1	HSD17B1	0.0007
6034	Hydroxyindole O-methyltransferase	ASMT	0.0007
6035	Nuclear receptor ROR-beta	RORB	0.0007
6036	Eosinophil peroxidase	EPX	0.0007
6344	ATP synthase subunit gamma, mitochondrial	ATP5C1	0.0007
6343	ATP synthase subunit beta, mitochondrial	ATP5B	0.0007
6342	ATP synthase subunit alpha, mitochondrial	ATP5A1	0.0007
6207	30S ribosomal protein S14	rpsN	0.0007
6209	30S ribosomal protein S19	rpsS	0.0007
6712	30S ribosomal protein S19	rpsS	0.0007
6726	30S ribosomal protein S19	rpsS	0.0007
645	Penicillin-binding protein 1A	mrcA	0.0007
5805	Penicillin-binding protein 1A	ponA	0.0007
6185	Penicillin-binding protein 1A	mrcA	0.0007
6799	Penicillin-binding protein 1A	pbpA	0.0007
6073	Potassium channel subfamily K member 9	KCNK9	0.0007
6072	Potassium channel subfamily K member 3	KCNK3	0.0007
2290	ADP-ribosyl cyclase 2	BST1	0.0007
226	Gonadotropin-releasing hormone receptor	GNRHR	0.0007
1830	5'-nucleotidase	NT5E	0.0007
125	DNA polymerase beta	POLB	0.0007
132	ATP-binding cassette sub-family A member 1	ABCA1	0.0007
291	Nitric-oxide synthase, endothelial	NOS3	0.0007
5463	Calcium-activated potassium channel subunit beta 2	KCNMB2	0.0007
131	Synaptic vesicular amine transporter	SLC18A2	0.0007
144	Hemoglobin subunit alpha	HBA1	0.0006
1507	Cytochrome c	CYCS	0.0006
6259	(3R)-hydroxymyristoyl-acyl carrier protein dehydratase	fabZ	0.0006
364	Corticosteroid 11-beta-dehydrogenase isozyme 1	HSD11B1	0.0006
765	Indoleamine 2,3-dioxygenase	IDO1	0.0006
3426	Glutamine synthetase	glnA	0.0006
3987	Glutamine synthetase	GLUL	0.0006
890	Niemann-Pick C1-like protein 1	NPC1L1	0.0006
3126	Poly [ADP-ribose] polymerase 1	PARP1	0.0006
6164	POU domain, class 5, transcription factor 1	POU5F1	0.0006
2404	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PIK3CG	0.0006
6167	Organic solute transporter subunit beta	OSTB	0.0006
6166	Organic solute transporter subunit alpha	OSTA	0.0006
1569	G1/S-specific cyclin-D1	CCND1	0.0006
1525	Heparin-binding growth factor 2	FGF2	0.0006
5221	Cytochrome c3, 13 kDa	Not Available	0.0006
3152	Cytochrome c''	cycA	0.0006
5220	Split-Soret cytochrome c	Ddes_2150	0.0006
3700	Cytochrome c-552 precursor	nrfA	0.0006
514	Potassium voltage-gated channel subfamily H member 6	KCNH6	0.0005
772	Potassium voltage-gated channel subfamily H member 7	KCNH7	0.0005
1760	Aminopeptidase N	ANPEP	0.0005
6843	Aminopeptidase N	pepN	0.0005
117	Sterol O-acyltransferase 1	SOAT1	0.0005
2347	Proto-oncogene serine/threonine-protein kinase Pim-1	PIM1	0.0005
1939	Heat shock protein HSP 90-alpha	HSP90AA1	0.0005
244	Angiotensin-converting enzyme	ACE	0.0005
6211	Tubulin epsilon chain	TUBE1	0.0005
6212	Tubulin gamma-1 chain	TUBG1	0.0005
6210	Tubulin delta chain	TUBD1	0.0005
4954	Soluble cytochrome b558	Not Available	0.0005
4916	Cyanoglobin	glbN	0.0005
4947	Bacterial hemoglobin	vhb	0.0005
4915	Cytochrome c-550	psbV	0.0005
4959	Cytochrome c-550	psbV	0.0005
5216	Cytochrome c-550	psbV	0.0005
4925	Cytochrome c-type protein SHP	shp	0.0005
4934	Cytochrome c-551	nirM	0.0005
5218	Cytochrome c-551	nirM	0.0005
4936	Cytochrome c2 iso-2	Not Available	0.0005
4943	Cytochrome c6	petJ	0.0005
4975	Cytochrome c-556	RPA3973	0.0005
4905	Cytochrome c2	Not Available	0.0005
4939	Cytochrome c2	cycA	0.0005
4964	Cytochrome c2	cycA	0.0005
4979	Cytochrome c2	cycA	0.0005
6673	Cytochrome c2	cycA	0.0005
4998	Hemoglobin-like protein yjbI	yjbI	0.0005
4994	Hemoglobin-like protein HbO	glbO	0.0005
5000	HemO	hemO	0.0005
4984	Neuroglobin	NGB	0.0005
4909	CooA protein	cooA	0.0005
4904	Cytochrome c family protein	GSU1996	0.0005
4910	Cytoglobin	CYGB	0.0005
4961	Hemophore HasA	hasA	0.0005
3116	Bacterioferritin	bfr	0.0005
4906	Bacterioferritin	bfr	0.0005
4965	Bacterioferritin	bfr	0.0005
4981	Iron-starvation protein PigA	pigA	0.0005
4935	Cytochrome c-554	cycA1	0.0005
4942	Diheme cytochrome c napB	napB	0.0005
4971	Nonaheme cytochrome c	hmcA	0.0005
644	Heme oxygenase 2	HMOX2	0.0005
4982	Heme oxygenase 2	pbsA2	0.0005
4907	Cytochrome c-L	moxG	0.0005
6865	Cytochrome c-L	moxG	0.0005
4989	Cytochrome c551 peroxidase	ccp	0.0005
5222	Cytochrome c551 peroxidase	ccpA	0.0005
4976	Apocytochrome f	petA	0.0005
6407	Apocytochrome f	petA	0.0005
4937	Cytochrome oxidase subunit II	rcoxA	0.0005
4764	Cytochrome P450 165C4	CYP165C4	0.0005
4931	Cytochrome P450 167A1	CYP167A1	0.0005
4999	Cytochrome P450 165B3	CYP165B3	0.0005
4960	Putative cytochrome P450-family protein	SCO7417	0.0005
4922	Cytochrome c, putative	SO_4144	0.0005
4926	Heme-based aerotactic transducer hemAT	hemAT	0.0005
4903	Methyl-accepting chemotaxis protein	Tar4	0.0005
4970	Cytochrome c nitrite reductase catalytic subunit	nrfA	0.0005
4993	Hydroxylamine oxidoreductase	hao1	0.0005
4972	P450cin	cinA	0.0005
4952	Catalase/peroxidase	katA	0.0005
3093	Catalase HPII	katE	0.0005
4908	Heme-regulated cyclic AMP phosphodiesterase	dosP	0.0005
6151	Monocarboxylate transporter 10	SLC16A10	0.0005
3127	Nitrite reductase	nirS	0.0005
3284	Nitrite reductase	nirS	0.0005
1714	Mitogen-activated protein kinase 3	MAPK3	0.0005
2236	Casein kinase II subunit alpha	CSNK2A1	0.0005
5878	Alpha-7 nicotinic cholinergic receptor subunit	CHRFAM7A	0.0004
3610	Thioredoxin reductase 1, cytoplasmic	TXNRD1	0.0004
505	Glutamate [NMDA] receptor subunit epsilon-3	GRIN2C	0.0004
2038	Inhibitor of nuclear factor kappa-B kinase subunit beta	IKBKB	0.0004
476	RAC-alpha serine/threonine-protein kinase	AKT1	0.0004
6161	Probable low affinity copper uptake protein 2	SLC31A2	0.0004
3405	Quinohaemoprotein ethanol dehydrogenase type-1	qheDH	0.0004
6042	Prostaglandin reductase 2	PTGR2	0.0004
6163	Copper-transporting ATPase 2	ATP7B	0.0004
6165	Copper-transporting ATPase 1	ATP7A	0.0004
935	Proto-oncogene tyrosine-protein kinase Yes	YES1	0.0004
1063	Signal transducer and activator of transcription 5B	STAT5B	0.0004
1176	Mitogen-activated protein kinase 1	MAPK1	0.0004
4152	Superoxide dismutase [Cu-Zn]	SOD1	0.0004
4920	Peroxidase/catalase	katG	0.0004
2119	Cytochrome b5	CYB5A	0.0004
4990	PpcA	ppcA	0.0004
4956	Quinohemoprotein alcohol dehydrogenase ADH IIB	qbdA	0.0004
3375	Acidic cytochrome c3	Not Available	0.0004
4988	Sulfite oxidase, mitochondrial	SUOX	0.0004
2915	Sensor protein fixL	fixL	0.0004
4944	Sensor protein fixL	fixL	0.0004
3570	Cytochrome P450 152A1	cypC	0.0004
4385	Cytochrome c'	Not Available	0.0004
4967	Cytochrome c'	cycA	0.0004
5038	Cytochrome c'	Not Available	0.0004
5223	Cytochrome c'	cycP	0.0004
4037	Hypothetical protein	GPX1	0.0004
4297	Hypothetical protein	SP_1951	0.0004
4521	Hypothetical protein	BC_2969	0.0004
4540	Hypothetical protein	TM_1070	0.0004
4555	Hypothetical protein	MT1739	0.0004
4569	Hypothetical protein	mshD	0.0004
4578	Hypothetical protein	PA3270	0.0004
4747	Hypothetical protein	PA3967	0.0004
5177	Hypothetical protein	TM_0096	0.0004
5194	Hypothetical protein	PA1204	0.0004
5240	Hypothetical protein	Rv2991	0.0004
5370	Hypothetical protein	TM_1158	0.0004
5710	Hypothetical protein	Tb927.5.1360	0.0004
4813	Heme oxygenase	hmuO	0.0004
5769	Heme oxygenase	Not Available	0.0004
4992	Cytochrome c peroxidase	Not Available	0.0004
4289	Cytochrome P450	TT_P0059	0.0004
6262	Cytochrome P450	staP	0.0004
2230	Catalase	CAT	0.0004
3249	Catalase	katA	0.0004
3625	Catalase	katA	0.0004
4539	Catalase	katA	0.0004
4941	Catalase	katB	0.0004
934	Proto-oncogene tyrosine-protein kinase Fyn	FYN	0.0004
76	Nitric-oxide synthase, brain	NOS1	0.0003
484	Tyrosine-protein kinase ABL2	ABL2	0.0003
2240	Cell division protein kinase 2	CDK2	0.0003
3670	Soluble cytochrome b562 precursor	cybC	0.0003
3411	Cytochrome P450 121	cyp121	0.0003
3291	Cytochrome c-552	cycA	0.0003
4927	Cytochrome c-552	nrfA	0.0003
4938	Cytochrome c-552	cycA	0.0003
4953	Cytochrome c-552	nrfA	0.0003
5217	Cytochrome c-552	cycM	0.0003
2617	Nitric oxide synthase oxygenase	nos	0.0003
2701	Nitric oxide synthase oxygenase	nos	0.0003
3102	Flavohemoprotein	hmp	0.0003
4969	Flavohemoprotein	hmp	0.0003
1313	Lactoylglutathione lyase	GLO1	0.0003
2845	Bifunctional P-450:NADPH-P450 reductase	CYP102A1	0.0003
2972	6-deoxyerythronolide B hydroxylase	eryF	0.0003
4608	Putative cytochrome P450	SCO1207	0.0003
4963	Putative cytochrome P450	SCO2884	0.0003
6254	Putative cytochrome P450	SCO6998	0.0003
6172	ATP-binding cassette sub-family B member 8, mitochondrial	ABCB8	0.0003
1360	Sphingomyelin phosphodiesterase	SMPD1	0.0003
358	Cystathionine beta-synthase	CBS	0.0002
693	Hemoglobin subunit beta	HBB	0.0002
337	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial	NDUFS7	0.0002
803	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	NDUFS2	0.0002
214	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	NDUFS3	0.0002
6168	Solute carrier family 22 member 16	SLC22A16	0.0002
6268	Hydroxyacid oxidase 1	HAO1	0.0002
6135	Sodium channel subunit beta-4	SCN4B	0.0002
6134	Sodium channel subunit beta-3	SCN3B	0.0002
6132	Sodium channel subunit beta-1	SCN1B	0.0002
6127	Carbonic anhydrase-related protein	CA8	0.0002
6128	Carbonic anhydrase-related protein 10	CA10	0.0002
6133	Sodium channel subunit beta-2	SCN2B	0.0002
6129	Carbonic anhydrase-related protein 11	CA11	0.0002
6861	Alcohol dehydrogenase [NADP+]	AKR1A1	0.0002
810	Heme oxygenase 1	HMOX1	0.0002
3391	Heme oxygenase 1	pbsA1	0.0002
3803	Sodium channel protein type 3 subunit alpha	SCN3A	0.0002
6130	Carbonic anhydrase 13	CA13	0.0002
6124	Carbonic anhydrase 5B, mitochondrial	CA5B	0.0002
6160	Solute carrier organic anion transporter family member 3A1	SLCO3A1	0.0002
3007	Carbonic anhydrase 12	CA12	0.0002
4205	Carbonic anhydrase 9	CA9	0.0002

(*) Categorization taken from DrugBank: therapeutic category or general category of a drug (i.e. anti-convulsant, antibacterial, etc.)

DB01039 - Fenofibrate

Targets

Enzymes

Predictions