DT-Web

DB01095 - Fluvastatin


Identification
Name Fluvastatin
Accession Number DB01095 (APRD00346)
Type small molecule
Description Fluvastatin is an antilipemic agent that competitively inhibits hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonic acid, the rate-limiting step in cholesterol biosynthesis. Fluvastatin belongs to a class of medications called statins and is used to reduce plasma cholesterol levels and prevent cardiovascular disease. It is also the first entirely synthetic HMG-CoA reductase inhibitor and is structurally distinct from the fungal derivatives of this therapeutic class.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 411.4659
Groups approved
Monoisotopic Weight 411.18458653
Pharmacology
Indication To be used as an adjunct to dietary therapy to prevent cardiovascular events. May be used as secondary prevention in patients with coronary heart disease (CHD) to reduce the risk of requiring coronary revascularization procedures, for reducing progression of coronary atherosclerosis in hypercholesterolemic patients with CHD, and for the treatment of primary hypercholesterolemia and mixed dyslidipidemia.
Mechanism of action Fluvastatin selectively and competitively inhibits the hepatic enzyme hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase. HMG-CoA reductase is responsible for converting HMG-CoA to mevalonate, the rate-limiting step in cholesterol biosynthesis. Inhibition results in a decrease in hepatic cholesterol levels which stimulates the synthesis of LDL receptors and increases hepatic uptake of LDL cholesterol. The end result is decreased levels of plasma total and LDL cholesterol.
Absorption Rapidly and almost completely absorbed (> 90%), but undergoes extensive first pass metabolism. Bioavailability is 24% (range 9-50%) when a 10 mg dose is given. The mean relative bioavailability of the extended-release tablet is 29% (range: 9% to 66%) compared to an immediate-release capsule administered under fasting conditions. When given orally, fluvastatin reaches peak concentrations (Tmax) in less than one hour. Taking the extended release tablet with a high-fat meal will delay absorption (Tmax = 6 hours) and increase bioavailability by approximately 50%. However, the maximum concentration of fluvastatin sodium extended-release tablets seen after a high fat meal is less than the peak concentration following a single dose or twice daily dose of the 40 mg fluvastatin capsule.
Protein binding 98% bound to plasma proteins. At therapeutic concentrations, the protein binding of fluvastatin is not affected by warfarin, salicylic acid and glyburide.
Biotransformation Undergoes hepatic metabolism primarily via hydroxylation of the indole ring at the 5- and 6-positions to 5-hydroxy fluvastatin and 6-hydroxy fluvastatin, respectively. N-dealkylation to N-desisopropyl fluvastatin and beta-oxidation of the side chain also occurs. Metabolized primarily by the CYP2C9 isozyme system (75%), and to a lesser extent by CYP3A4 (~20%) and CYP2C8 (~5%). Hydroxylated metabolites retain some pharmcological activity, but are present as conjugates (glucuronides and sulfates) in the blood and are rapidly eliminated via bile into feces. Both enantiomers of fluvastatin are metabolized in a similar manner. Fluvastatin also undergoes glucuronidation via UGT enzymes.
Route of elimination When orally administered, fluvastatin is primarily excreted in the faces ( ~90%) as metabolites, with less than 2% present as unchanged drug. Approximately 5% was recovered in the urine.
Toxicity Generally well-tolerated. May cause gastrointestinal upset (diarrhea, nausea, constipation, gas, abdominal pain), myotoxicity (mypothy, myositis, rhabdomyolysis), and hepatotoxicity.
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Acenocoumarol Fluvastatin may increase the anticoagulant effect of acenocoumarol. Monitor for changes in the therapeutic and adverse effects of acenocoumarol if fluvastatin is initiated, discontinued or dose changed.
Anisindione Fluvastatin may increase the anticoagulant effect of anisindione. Monitor for changes in the therapeutic and adverse effects of anisindione if fluvastatin if initiated, discontinued or dose changed.
Bezafibrate Increased risk of myopathy/rhabdomyolysis
Cholestyramine Increased/decreased effect according to spacing
Colchicine Increased risk of rhabdomyolysis with this combination
Colestipol Increased/decreased effect according to spacing
Cyclosporine Possible myopathy and rhabdomyolysis
Dicumarol Fluvastatin may increase the anticoagulant effect of dicumarol. Monitor for changes in the therapeutic and adverse effects of dicumarol if fluvastatin if initiated, discontinued or dose changed.
Eltrombopag Increases levels of Fluvastatin via metabolism decrease. OATP transporter protein inhibition.
Etravirine Fluvastatin, when administered concomitantly with etravirin, may experience an increase in serum concentration. It is recommended to monitor for signs of toxicity from fluvastatin, such as myopathy and hepatic enzyme elevations.
Fenofibrate Increased risk of myopathy/rhabdomyolysis
Fluconazole Fluconazole may increase the serum concentration of fluvastatin by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of fluvastatin if fluconazole is initiated, discontinued or dose changed.
Gemfibrozil Increased risk of myopathy/rhabdomyolysis
Repaglinide Inhibitors of CYP3A4 and P-glycoprotein may increase serum concentrations of repaglinide. Monitor concomitant therapy closely.
Rifabutin Rifabutin may decrease the effect of fluvastatin by increasing its metabolism. Monitor for changes in the therapeutic and adverse effects of fluvastatin if rifabutin is initiated, discontinued or dose changed.
Rifampin Rifampin may decrease the effect of fluvastatin by increasing its metabolism. Monitor for changes in the therapeutic and adverse effects of fluvastatin if rifampin is initiated, discontinued or dose changed.
Warfarin Fluvastatin may increase the anticoagulant effect of warfarin. Monitor for changes in the therapeutic and adverse effects of warfarin if fluvastatin is initiated, discontinued or dose changed.
Food Interactions
  • May be taken with or without food, but should be taken consistently.
  • When given with an evening meal, Cmax and AUC decreased while Tmax increased 2-fold

Targets


3-hydroxy-3-methylglutaryl-coenzyme A reductase
Name 3-hydroxy-3-methylglutaryl-coenzyme A reductase
Gene Name HMGCR
Pharmacological action yes
Actions inhibitor
References
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
  • Podar K, Tai YT, Hideshima T, Vallet S, Richardson PG, Anderson KC: Emerging therapies for multiple myeloma. Expert Opin Emerg Drugs. 2009 Mar;14(1):99-127. - Pubmed
DTHybrid score 0.441

Enzymes


Cytochrome P450 1A1
Name Cytochrome P450 1A1
Gene Name CYP1A1
Actions substrate
References
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.3449
Cytochrome P450 1A2
Name Cytochrome P450 1A2
Gene Name CYP1A2
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.6362
Cytochrome P450 3A4
Name Cytochrome P450 3A4
Gene Name CYP3A4
Actions substrate,inhibitor,inducer
References
  • Fischer V, Johanson L, Heitz F, Tullman R, Graham E, Baldeck JP, Robinson WT: The 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor fluvastatin: effect on human cytochrome P-450 and implications for metabolic drug interactions. Drug Metab Dispos. 1999 Mar;27(3):410-6. - Pubmed
  • Toda T, Eliasson E, Ask B, Inotsume N, Rane A: Roles of different CYP enzymes in the formation of specific fluvastatin metabolites by human liver microsomes Basic Clin Pharmacol Toxicol. 2009 Nov;105(5):327-32. - Pubmed
  • Scripture CD, Pieper JA: Clinical pharmacokinetics of fluvastatin. Clin Pharmacokinet. 2001;40(4):263-81. - Pubmed
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.9796
Cytochrome P450 3A5
Name Cytochrome P450 3A5
Gene Name CYP3A5
Actions substrate
References
  • Kivisto KT, Niemi M, Schaeffeler E, Pitkala K, Tilvis R, Fromm MF, Schwab M, Eichelbaum M, Strandberg T: Lipid-lowering response to statins is affected by CYP3A5 polymorphism. Pharmacogenetics. 2004 Aug;14(8):523-5. - Pubmed
DTHybrid score 0.5046
Cytochrome P450 2B6
Name Cytochrome P450 2B6
Gene Name CYP2B6
Actions inducer
References
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
DTHybrid score 0.457
Cytochrome P450 2C8
Name Cytochrome P450 2C8
Gene Name CYP2C8
Actions substrate,inhibitor
References
  • Fischer V, Johanson L, Heitz F, Tullman R, Graham E, Baldeck JP, Robinson WT: The 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor fluvastatin: effect on human cytochrome P-450 and implications for metabolic drug interactions. Drug Metab Dispos. 1999 Mar;27(3):410-6. - Pubmed
  • Toda T, Eliasson E, Ask B, Inotsume N, Rane A: Roles of different CYP enzymes in the formation of specific fluvastatin metabolites by human liver microsomes. Basic Clin Pharmacol Toxicol. 2009 Nov;105(5):327-32. - Pubmed
  • Scripture CD, Pieper JA: Clinical pharmacokinetics of fluvastatin. Clin Pharmacokinet. 2001;40(4):263-81. - Pubmed
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.6046
Cytochrome P450 2C9
Name Cytochrome P450 2C9
Gene Name CYP2C9
Actions substrate,inhibitor,inducer
References
  • Fischer V, Johanson L, Heitz F, Tullman R, Graham E, Baldeck JP, Robinson WT: The 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor fluvastatin: effect on human cytochrome P-450 and implications for metabolic drug interactions. Drug Metab Dispos. 1999 Mar;27(3):410-6. - Pubmed
  • Toda T, Eliasson E, Ask B, Inotsume N, Rane A: Roles of different CYP enzymes in the formation of specific fluvastatin metabolites by human liver microsomes. Basic Clin Pharmacol Toxicol. 2009 Nov;105(5):327-32. - Pubmed
  • Scripture CD, Pieper JA: Clinical pharmacokinetics of fluvastatin. Clin Pharmacokinet. 2001;40(4):263-81. - Pubmed
  • Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.7725
Cytochrome P450 2C19
Name Cytochrome P450 2C19
Gene Name CYP2C19
Actions inhibitor
References
  • Cohen LH, van Leeuwen RE, van Thiel GC, van Pelt JF, Yap SH: Equally potent inhibitors of cholesterol synthesis in human hepatocytes have distinguishable effects on different cytochrome P450 enzymes. Biopharm Drug Dispos. 2000 Dec;21(9):353-64. - Pubmed
DTHybrid score 0.639
Cytochrome P450 2D6
Name Cytochrome P450 2D6
Gene Name CYP2D6
Actions substrate,inhibitor
References
  • Cohen LH, van Leeuwen RE, van Thiel GC, van Pelt JF, Yap SH: Equally potent inhibitors of cholesterol synthesis in human hepatocytes have distinguishable effects on different cytochrome P450 enzymes. Biopharm Drug Dispos. 2000 Dec;21(9):353-64. - Pubmed
  • Scripture CD, Pieper JA: Clinical pharmacokinetics of fluvastatin. Clin Pharmacokinet. 2001;40(4):263-81. - Pubmed
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.6873
UDP-glucuronosyltransferase 1-1
Name UDP-glucuronosyltransferase 1-1
Gene Name UGT1A1
Actions substrate
References
  • http://www.pharmacologyweekly.com/content/pages/ugt-enzymes-medications-herbs-substrate-inhibitor-inducer -
DTHybrid score 0.3559
UDP-glucuronosyltransferase 1-3
Name UDP-glucuronosyltransferase 1-3
Gene Name UGT1A3
Actions substrate
References
  • http://www.pharmacologyweekly.com/content/pages/ugt-enzymes-medications-herbs-substrate-inhibitor-inducer -
DTHybrid score 0.3151
UDP-glucuronosyltransferase 2B7
Name UDP-glucuronosyltransferase 2B7
Gene Name UGT2B7
Actions substrate
References
  • http://www.pharmacologyweekly.com/content/pages/ugt-enzymes-medications-herbs-substrate-inhibitor-inducer -
DTHybrid score 0.3326

Transporters


Solute carrier organic anion transporter family member 1B1
Name Solute carrier organic anion transporter family member 1B1
Gene Name SLCO1B1
Actions Not Available
References
  • Kopplow K, Letschert K, Konig J, Walter B, Keppler D: Human hepatobiliary transport of organic anions analyzed by quadruple-transfected cells. Mol Pharmacol. 2005 Oct;68(4):1031-8. Epub 2005 Jul 26. - Pubmed
DTHybrid score 0.4639
Solute carrier organic anion transporter family member 1B3
Name Solute carrier organic anion transporter family member 1B3
Gene Name SLCO1B3
Actions Not Available
References
  • Kopplow K, Letschert K, Konig J, Walter B, Keppler D: Human hepatobiliary transport of organic anions analyzed by quadruple-transfected cells. Mol Pharmacol. 2005 Oct;68(4):1031-8. Epub 2005 Jul 26. - Pubmed
DTHybrid score 0.3026
Solute carrier organic anion transporter family member 2B1
Name Solute carrier organic anion transporter family member 2B1
Gene Name SLCO2B1
Actions Not Available
References
  • Kopplow K, Letschert K, Konig J, Walter B, Keppler D: Human hepatobiliary transport of organic anions analyzed by quadruple-transfected cells. Mol Pharmacol. 2005 Oct;68(4):1031-8. Epub 2005 Jul 26. - Pubmed
DTHybrid score 0.2998
Oligopeptide transporter, small intestine isoform
Name Oligopeptide transporter, small intestine isoform
Gene Name SLC15A1
Actions substrate,inhibitor
References
  • Ekins S, Johnston JS, Bahadduri P, D'Souza VM, Ray A, Chang C, Swaan PW: In vitro and pharmacophore-based discovery of novel hPEPT1 inhibitors. Pharm Res. 2005 Apr;22(4):512-7. Epub 2005 Apr 7. - Pubmed
DTHybrid score 0.315

Predictions


Id Partner name Gene Name Score
1588 Multidrug resistance protein 1 ABCB1 0.5408
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.441
6107 Cytochrome P450 3A7 CYP3A7 0.3176
6013 Cytochrome P450 2E1 CYP2E1 0.2458
587 Serum albumin ALB 0.2375
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.2326
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.2211
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.2078
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.2034
20 Prostaglandin G/H synthase 1 PTGS1 0.2004
5718 Cytochrome P450 2A6 CYP2A6 0.1877
1729 Solute carrier family 22 member 6 SLC22A6 0.1814
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.1437
862 Multidrug resistance-associated protein 1 ABCC1 0.1383
6142 Solute carrier family 22 member 8 SLC22A8 0.1351
290 Prostaglandin G/H synthase 2 PTGS2 0.1115
2164 Multidrug resistance-associated protein 4 ABCC4 0.1112
492 Histamine H1 receptor HRH1 0.11
6106 Cytochrome P450 2C18 CYP2C18 0.1043
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0963
244 Angiotensin-converting enzyme ACE 0.0949
6145 Solute carrier family 22 member 1 SLC22A1 0.0937
118 Organic cation/carnitine transporter 2 SLC22A5 0.0926
776 Bile salt export pump ABCB11 0.0926
1898 Cytochrome P450 1B1 CYP1B1 0.0906
4604 Liver carboxylesterase 1 CES1 0.0861
824 Sodium-dependent serotonin transporter SLC6A4 0.0823
70 Type-1 angiotensin II receptor AGTR1 0.077
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0769
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0748
556 Alpha-1A adrenergic receptor ADRA1A 0.0712
6143 Solute carrier family 22 member 7 SLC22A7 0.0711
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0703
3811 Cytochrome P450 19A1 CYP19A1 0.0696
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0696
738 Monocarboxylate transporter 1 SLC16A1 0.0693
1024 Solute carrier family 22 member 11 SLC22A11 0.0683
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0681
502 5-hydroxytryptamine 2A receptor HTR2A 0.0681
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0668
847 Mu-type opioid receptor OPRM1 0.0639
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0624
318 Alpha-2A adrenergic receptor ADRA2A 0.0618
831 D(2) dopamine receptor DRD2 0.0617
6144 Solute carrier family 22 member 2 SLC22A2 0.0608
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.059
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0578
467 Delta-type opioid receptor OPRD1 0.0571
6141 Sodium/bile acid cotransporter SLC10A1 0.057
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0568
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0567
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0563
696 Kappa-type opioid receptor OPRK1 0.0556
136 Estrogen receptor ESR1 0.0554
766 Beta-2 adrenergic receptor ADRB2 0.0539
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0514
468 Cytochrome P450 4A11 CYP4A11 0.0511
633 Penicillin-binding proteins 1A/1B pbpA 0.0497
590 5-hydroxytryptamine 2C receptor HTR2C 0.049
320 5-hydroxytryptamine 1A receptor HTR1A 0.0489
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0488
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0486
632 Alpha-1B adrenergic receptor ADRA1B 0.0476
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0471
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0471
731 HIV-1 protease HIV-1 protease 0.0467
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0465
713 Sodium-dependent dopamine transporter SLC6A3 0.0463
6136 Multidrug resistance-associated protein 5 ABCC5 0.0456
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0449
5880 Thrombopoietin receptor MPL 0.0442
341 5-hydroxytryptamine 3 receptor HTR3A 0.0439
4589 3-hydroxy-3-methylglutaryl CoA synthase mvaS 0.0417
6031 Cytochrome P450 3A43 CYP3A43 0.0413
193 Beta-1 adrenergic receptor ADRB1 0.0403
23 D(1A) dopamine receptor DRD1 0.0402
6220 Aryl hydrocarbon receptor AHR 0.0402
817 DNA topoisomerase 2-alpha TOP2A 0.0395
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0394
3941 Amine oxidase [flavin-containing] A MAOA 0.0394
6148 Multidrug resistance-associated protein 7 ABCC10 0.0392
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0392
833 Organic cation/carnitine transporter 1 SLC22A4 0.0384
871 Glucocorticoid receptor NR3C1 0.0384
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0379
6147 Solute carrier family 22 member 3 SLC22A3 0.0374
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0361
3587 Gastrotropin FABP6 0.0358
146 Androgen receptor AR 0.0357
260 Cytochrome P450 51 ERG11 0.0337
761 Cytochrome P450 51 ERG11 0.0337
3163 Cytochrome P450 51 cyp51 0.0337
3810 Catechol O-methyltransferase COMT 0.0335
465 Calmodulin CALM1 0.0333
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0332
3923 Cholinesterase BCHE 0.0329
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0328
504 Mast/stem cell growth factor receptor KIT 0.0327
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0327
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0327
26 Vascular endothelial growth factor receptor 3 FLT4 0.0325
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0321
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0319
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0313
638 D(3) dopamine receptor DRD3 0.0312
32 Vascular endothelial growth factor receptor 1 FLT1 0.0311
885 5-hydroxytryptamine 1B receptor HTR1B 0.0302
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0301
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0299
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0297
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0297
1757 Myeloperoxidase MPO 0.0295
1630 Integrin beta-2 ITGB2 0.0294
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0293
789 Alpha-1D adrenergic receptor ADRA1D 0.0291
407 Vascular endothelial growth factor receptor 2 KDR 0.029
122 P2Y purinoceptor 12 P2RY12 0.0289
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0288
33 Cystine/glutamate transporter SLC7A11 0.0285
6102 Arylamine N-acetyltransferase 2 NAT2 0.0283
606 Cytochrome P450 27, mitochondrial CYP27A1 0.028
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0278
29 Tubulin beta-1 chain TUBB1 0.0274
6026 Alcohol dehydrogenase 6 ADH6 0.0273
6182 Cytochrome P450 2J2 CYP2J2 0.0273
3939 Amine oxidase [flavin-containing] B MAOB 0.0272
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0268
4122 Histone deacetylase 2 HDAC2 0.0262
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0262
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.026
6167 Organic solute transporter subunit beta OSTB 0.0259
6166 Organic solute transporter subunit alpha OSTA 0.0259
36 Insulin receptor INSR 0.0258
373 Transthyretin TTR 0.0258
811 Translocator protein TSPO 0.0257
6044 Serum paraoxonase/lactonase 3 PON3 0.0253
725 5-hydroxytryptamine 1D receptor HTR1D 0.0248
6085 Fatty acid-binding protein, intestinal FABP2 0.0245
844 Epidermal growth factor receptor EGFR 0.0244
777 Tumor necrosis factor TNF 0.024
629 Alpha-2B adrenergic receptor ADRA2B 0.0238
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0238
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0237
273 Apoptosis regulator Bcl-2 BCL2 0.0235
1 Peptidoglycan synthetase ftsI ftsI 0.0235
4155 Peptidoglycan synthetase ftsI ftsI 0.0235
275 Arachidonate 5-lipoxygenase ALOX5 0.0235
117 Sterol O-acyltransferase 1 SOAT1 0.0235
952 Dipeptidyl peptidase 4 DPP4 0.0235
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0232
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0231
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.023
645 Penicillin-binding protein 1A mrcA 0.0228
5805 Penicillin-binding protein 1A ponA 0.0228
6185 Penicillin-binding protein 1A mrcA 0.0228
6799 Penicillin-binding protein 1A pbpA 0.0228
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0228
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0227
228 Beta platelet-derived growth factor receptor PDGFRB 0.0226
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0224
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0223
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0222
1385 Angiotensin-converting enzyme 2 ACE2 0.0222
758 Thyroid hormone receptor alpha THRA 0.022
6137 Multidrug resistance-associated protein 6 ABCC6 0.0218
432 D(4) dopamine receptor DRD4 0.0214
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0213
6014 Cytochrome P450 2A13 CYP2A13 0.0213
891 Dihydropteroate synthase folP 0.0212
5359 Dihydropteroate synthase folP 0.0212
7175 Dihydropteroate synthase sulI 0.0212
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0211
378 Alpha-2C adrenergic receptor ADRA2C 0.021
1760 Aminopeptidase N ANPEP 0.021
6843 Aminopeptidase N pepN 0.021
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0209
572 Integrin alpha-L ITGAL 0.0209
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0208
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0208
756 Sex hormone-binding globulin SHBG 0.0208
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0205
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0199
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0197
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0197
346 Thyroid hormone receptor beta-1 THRB 0.0196
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0194
594 Thyroxine-binding globulin SERPINA7 0.0194
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0191
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0188
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0187
477 DNA topoisomerase 4 subunit A parC 0.0186
886 DNA topoisomerase 4 subunit A parC 0.0186
6226 DNA topoisomerase 4 subunit A parC 0.0186
869 Estrogen receptor beta ESR2 0.0184
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0184
404 DNA gyrase subunit A gyrA 0.0183
6224 DNA gyrase subunit A gyrA 0.0183
2539 Tubulin alpha-1 chain TUBA4A 0.0181
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0181
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0177
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0176
614 Progesterone receptor PGR 0.0174
543 Penicillin-binding protein 1B mrcB 0.0174
6186 Penicillin-binding protein 1B ponB 0.0174
6822 Penicillin-binding protein 1b pbp1b 0.0174
6844 Penicillin-binding protein 1b pbp1b 0.0174
4120 NADPH--cytochrome P450 reductase POR 0.0174
1010 Cytochrome P450 51A1 CYP51A1 0.0173
4164 Potassium voltage-gated channel subfamily KQT member 5 KCNQ5 0.0173
4163 Potassium voltage-gated channel subfamily KQT member 4 KCNQ4 0.0173
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0173
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0172
672 Prostaglandin F2-alpha receptor PTGFR 0.0171
3233 Bile acid receptor NR1H4 0.0171
1629 Transcription factor AP-1 JUN 0.0171
6599 HTH-type transcriptional regulator ttgR ttgR 0.0171
380 Cytochrome P450 17A1 CYP17A1 0.0168
471 Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) SLC6A14 0.0166
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0165
267 Plasminogen activator inhibitor 1 SERPINE1 0.0165
3809 Estrogen-related receptor gamma ESRRG 0.0164
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0164
1792 Tissue-type plasminogen activator PLAT 0.0163
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0161
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.016
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0157
319 Opioid receptor, sigma 1 OPRS1 0.0157
2021 Thrombomodulin THBD 0.0156
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0154
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0154
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0154
365 Dihydrofolate reductase DHFR 0.0154
2381 Dihydrofolate reductase DFR1 0.0154
2833 Dihydrofolate reductase Not Available 0.0154
2931 Dihydrofolate reductase folA 0.0154
3544 Dihydrofolate reductase folA 0.0154
3682 Dihydrofolate reductase folA 0.0154
6642 Dihydrofolate reductase folA 0.0154
6756 Dihydrofolate reductase dfrA 0.0154
723 Cytosolic phospholipase A2 PLA2G4A 0.0153
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0153
124 Histamine H2 receptor HRH2 0.0153
94 5-hydroxytryptamine 4 receptor HTR4 0.0153
6138 Multidrug resistance protein 3 ABCB4 0.0151
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0151
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0151
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0151
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0151
818 50S ribosomal protein L10 rplJ 0.015
6221 Steroid hormone receptor ERR1 ESRRA 0.015
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0149
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0149
436 5-hydroxytryptamine 2B receptor HTR2B 0.0149
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0149
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0149
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0149
459 Retinoic acid receptor RXR-alpha RXRA 0.0147
163 D(1B) dopamine receptor DRD5 0.0146
6151 Monocarboxylate transporter 10 SLC16A10 0.0146
1656 CYP2B protein CYP2B 0.0145
4148 Serine/threonine-protein kinase mTOR MTOR 0.0145
6020 Aldehyde oxidase AOX1 0.0144
588 Chromodomain-helicase-DNA-binding protein 1 CHD1 0.0144
3947 Xanthine dehydrogenase/oxidase XDH 0.0144
284 DNA-directed RNA polymerase beta chain rpoB 0.0144
5773 DNA-directed RNA polymerase beta chain rpoB 0.0144
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0144
16 Adenosine A1 receptor ADORA1 0.0142
716 5-hydroxytryptamine 7 receptor HTR7 0.014
232 Corticosteroid-binding globulin SERPINA6 0.0139
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0137
1178 Adenosine A2a receptor ADORA2A 0.0137
571 Melatonin receptor type 1A MTNR1A 0.0136
362 Melatonin receptor type 1B MTNR1B 0.0136
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0136
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0135
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0134
6149 Solute carrier family 22 member 10 SLC22A10 0.0134
737 Mineralocorticoid receptor NR3C2 0.0134
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0132
427 Substance-P receptor TACR1 0.0132
1517 Beta-3 adrenergic receptor ADRB3 0.013
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0129
3917 Methylenetetrahydrofolate reductase MTHFR 0.0129
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0128
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0128
823 Fibroblast growth factor receptor 2 FGFR2 0.0128
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0127
48 Pyridoxal kinase PDXK 0.0125
174 Sigma 1-type opioid receptor SIGMAR1 0.0125
482 Glycine receptor subunit alpha-1 GLRA1 0.0125
705 Glutamate receptor 1 GRIA1 0.0125
54 Prothrombin F2 0.0124
613 Atrial natriuretic peptide receptor A NPR1 0.0122
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0122
605 Fumarate reductase flavoprotein subunit frdA 0.0121
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0121
3673 Fumarate reductase flavoprotein subunit fccA 0.0121
4912 Fumarate reductase flavoprotein subunit ifcA 0.0121
6549 Fumarate reductase flavoprotein subunit frdA 0.0121
161 Tubulin beta chain TUBB 0.012
312 Tubulin beta chain TUB2 0.012
3932 Glutathione S-transferase A2 GSTA2 0.012
4203 Histamine N-methyltransferase HNMT 0.012
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0119
500 Monocarboxylate transporter 4 SLC16A3 0.0118
295 Carbonic anhydrase 1 CA1 0.0118
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0117
199 Monocarboxylate transporter 8 SLC16A2 0.0115
6043 Putative G-protein coupled receptor 44 GPR44 0.0115
2112 Toll-like receptor 9 TLR9 0.0115
3856 Fibroblast growth factor receptor 3 FGFR3 0.0115
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0114
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0114
474 Acetylcholinesterase ACHE 0.0113
2449 Tubulin alpha-3 chain TUBA1A 0.0113
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0113
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0113
2499 Tubulin beta-2C chain TUBB2C 0.0113
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0112
1852 Microtubule-associated protein 2 MAP2 0.0112
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0112
1192 Sulfotransferase 1A1 SULT1A1 0.0111
5923 Microtubule-associated protein tau MAPT 0.0111
5924 Microtubule-associated protein 4 MAP4 0.0111
2981 Phospholipase A2, membrane associated PLA2G2A 0.0108
115 Penicillin-binding protein 2 mrdA 0.0108
6069 Penicillin-binding protein 2 mrdA 0.0108
6118 Penicillin-binding protein 2 penA 0.0108
6187 Penicillin-binding protein 2 pbpA 0.0108
6686 Penicillin-binding protein 2 pbp2 0.0108
6939 Penicillin-binding protein 2 mrdA 0.0108
7163 Penicillin-binding protein 2 pbpA 0.0108
921 Glutamate receptor 2 GRIA2 0.0107
6067 Penicillin binding protein 2a mecA 0.0107
56 Delta-aminolevulinic acid dehydratase ALAD 0.0106
2356 Delta-aminolevulinic acid dehydratase hemB 0.0106
3613 Delta-aminolevulinic acid dehydratase hemB 0.0106
3674 Delta-aminolevulinic acid dehydratase hemB 0.0106
563 Thyroid peroxidase TPO 0.0106
592 Carbonic anhydrase 4 CA4 0.0105
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0105
611 Retinal dehydrogenase 1 ALDH1A1 0.0104
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0104
1039 Histone deacetylase 9 HDAC9 0.0103
489 Monocarboxylate transporter 2 SLC16A7 0.0103
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0102
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0102
1618 High affinity nerve growth factor receptor NTRK1 0.0101
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0101
4311 tRNA TRDMT1 0.0101
4325 tRNA trmD 0.0101
4328 tRNA trmD 0.0101
1256 5-hydroxytryptamine 6 receptor HTR6 0.01
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0099
1050 Bile salt sulfotransferase SULT2A1 0.0099
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0099
5650 NimA-related protein DR_0842 0.0098
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0097
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0097
4116 Dihydropteroate synthetase Not Available 0.0097
527 Prostacyclin receptor PTGIR 0.0097
131 Synaptic vesicular amine transporter SLC18A2 0.0097
958 Insulin-like growth factor 1 receptor IGF1R 0.0097
49 Endothelin B receptor EDNRB 0.0096
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0096
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0095
511 5-hydroxytryptamine 1F receptor HTR1F 0.0094
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0094
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0094
596 3-oxo-5-alpha-steroid 4-dehydrogenase 1 SRD5A1 0.0094
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0094
165 FL cytokine receptor FLT3 0.0094
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0093
1275 Estrogen sulfotransferase SULT1E1 0.0092
5300 Antigen peptide transporter 1 TAP1 0.0092
2544 Bacterial leucyl aminopeptidase Not Available 0.0092
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0091
860 Nicotinamide N-methyltransferase NNMT 0.0091
583 Nicotinate-nucleotide pyrophosphorylase [carboxylating] QPRT 0.0091
2442 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0091
2459 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0091
699 Nicotinic acid receptor 1 GPR109A 0.0091
928 Nicotinic acid receptor 2 GPR109B 0.0091
102 DNA topoisomerase I, mitochondrial TOP1MT 0.009
578 Endothelin-1 receptor EDNRA 0.009
4228 Keratin, type II cytoskeletal 7 KRT7 0.009
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0089
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.0088
84 Nuclear receptor 0B1 NR0B1 0.0088
3317 Holo-[acyl-carrier-protein] synthase acpS 0.0088
4381 Holo-[acyl-carrier-protein] synthase acpS 0.0088
3125 Protease synthase and sporulation negative regulatory protein PAI 1 paiA 0.0088
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0088
88 Retinoic acid receptor RXR-beta RXRB 0.0088
814 Ryanodine receptor 1 RYR1 0.0087
528 5-hydroxytryptamine 1E receptor HTR1E 0.0086
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0085
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0085
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0085
581 Cytochrome P450 2R1 CYP2R1 0.0085
856 Vitamin D3 receptor VDR 0.0084
790 DNA polymerase subunit alpha B POLA2 0.0084
6146 High affinity copper uptake protein 1 SLC31A1 0.0084
642 3-oxo-5-alpha-steroid 4-dehydrogenase 2 SRD5A2 0.0083
820 Glycine receptor subunit alpha-2 GLRA2 0.0083
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0083
904 Glutathione S-transferase P GSTP1 0.0083
68 Cannabinoid receptor 1 CNR1 0.0083
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0083
6113 MecA PBP2' (penicillin binding protein 2') mecA 0.0082
24 Thymidylate synthase TMP1 0.0082
359 Thymidylate synthase TYMS 0.0082
2626 Thymidylate synthase thyA 0.0082
2729 Thymidylate synthase thyA 0.0082
5352 Thymidylate synthase THYA 0.0082
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0081
239 Coagulation factor X F10 0.008
565 Extracellular calcium-sensing receptor CASR 0.008
208 DNA-directed RNA polymerase beta' chain rpoC 0.008
5774 DNA-directed RNA polymerase beta' chain rpoC 0.008
183 Vascular endothelial growth factor A VEGFA 0.008
2636 Shikimate dehydrogenase aroE 0.0079
3515 Shikimate dehydrogenase aroE 0.0079
3254 Bifunctional protein putA [Includes: Proline dehydrogenase putA 0.0079
768 FK506-binding protein 1A FKBP1A 0.0079
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0079
173 Toll-like receptor 7 TLR7 0.0079
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0078
357 Carbonic anhydrase 2 CA2 0.0078
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0078
442 Envelope glycoprotein gp41 0.0078
4859 Envelope glycoprotein env 0.0078
936 Ephrin type-A receptor 2 EPHA2 0.0077
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0077
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0077
537 ATP synthase delta chain, mitochondrial ATP5D 0.0077
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0076
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0076
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0076
1353 DNA topoisomerase 1 TOP1 0.0075
3552 DNA topoisomerase 1 topA 0.0075
4192 DNA topoisomerase 2-beta TOP2B 0.0075
1541 Metalloproteinase mmp20 0.0074
780 Retinoic acid receptor RXR-gamma RXRG 0.0073
2183 Fatty acid-binding protein, adipocyte FABP4 0.0072
5787 Angiopoietin-1 receptor TEK 0.0071
518 Peroxidase/catalase T katG 0.0071
976 Platelet glycoprotein IX GP9 0.0071
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0071
908 Glutathione S-transferase theta-1 GSTT1 0.0071
634 Squalene monooxygenase SQLE 0.0071
7196 Squalene monooxygenase ERG1 0.0071
3937 Fatty-acid amide hydrolase FAAH 0.007
1992 Vitamin D-binding protein GC 0.007
6126 Carbonic anhydrase 7 CA7 0.007
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.007
3060 Leukotriene A-4 hydrolase LTA4H 0.0069
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.0069
469 Annexin A1 ANXA1 0.0068
5599 3-carboxy-cis,cis-muconate cycloisomerase pcaB 0.0068
1141 Sialidase-1 NEU1 0.0068
64 Neuraminidase NA 0.0068
641 Neuraminidase NA 0.0068
2676 Neuraminidase NA 0.0068
3026 Neuraminidase NA 0.0068
3519 Neuraminidase NA 0.0068
6007 Neuraminidase NA 0.0068
3086 Plasmepsin-2 Not Available 0.0068
4217 Telomerase reverse transcriptase TERT 0.0067
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0067
153 Dopamine beta-hydroxylase DBH 0.0067
444 Alcohol dehydrogenase 1B ADH1B 0.0066
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0066
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0066
5934 Cytochrome P450 26A1 CYP26A1 0.0066
5669 50S ribosomal protein L27 rpmA 0.0066
5675 Chaperone protein torD torD 0.0065
5670 Organic hydroperoxide resistance protein ohr 0.0065
5672 Molybdenum cofactor biosynthesis protein A moaA 0.0065
5410 Unsaturated glucuronyl hydrolase ugl 0.0065
5676 Axin-1 AXIN1 0.0065
5673 C protein alpha-antigen bca 0.0065
517 Alcohol dehydrogenase 1C ADH1C 0.0065
1820 Beta-nerve growth factor NGF 0.0064
569 Retinal dehydrogenase 2 ALDH1A2 0.0063
1648 Elastin ELN 0.0063
6432 Transporter snf 0.0063
133 Dihydropterate synthase sulI 0.0063
162 Retinoic acid receptor gamma-1 RARG 0.0062
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0062
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0062
65 Matrix metalloproteinase-9 Not Available 0.0062
760 Fibroblast growth factor 1 FGF1 0.0061
6174 50S ribosomal protein L32 rpmF 0.0061
4237 50S ribosomal protein L22 rplV 0.006
5798 Mitogen-activated protein kinase 11 MAPK11 0.006
1196 Complement decay-accelerating factor CD55 0.006
707 72 kDa type IV collagenase MMP2 0.0059
4103 Proteasome subunit beta type 2 PSMB2 0.0059
4102 Proteasome subunit beta type 5 PSMB5 0.0059
4101 Proteasome subunit beta type 1 PSMB1 0.0059
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0059
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0059
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0059
2285 Streptogramin A acetyltransferase vatD 0.0059
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.0058
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0058
6766 O-GlcNAcase BT_4395 BT_4395 0.0058
751 Potassium channel subfamily K member 6 KCNK6 0.0057
251 Alcohol dehydrogenase 1A ADH1A 0.0057
6832 Serine/threonine-protein kinase SRPK2 SRPK2 0.0057
106 Cannabinoid receptor 2 CNR2 0.0057
6579 Calcium/calmodulin-dependent protein kinase type II alpha chain CAMK2A 0.0057
1714 Mitogen-activated protein kinase 3 MAPK3 0.0056
159 Penicillin-binding protein 2B penA 0.0056
6121 Penicillin-binding protein 2B penA 0.0056
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0056
6506 Stathmin-4 STMN4 0.0055
558 Solute carrier family 12 member 1 SLC12A1 0.0054
6042 Prostaglandin reductase 2 PTGR2 0.0054
4252 Penicillin-binding protein 5 dacA 0.0054
1483 Membrane copper amine oxidase AOC3 0.0054
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0053
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0053
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0053
7 Nitric oxide synthase, inducible NOS2 0.0053
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0053
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0053
5998 Toll-like receptor 8 TLR8 0.0053
172 Potassium channel subfamily K member 1 KCNK1 0.0053
4811 Amylosucrase ams 0.0053
1525 Heparin-binding growth factor 2 FGF2 0.0053
2280 Listeriolysin regulatory protein prfA 0.0052
2320 Thymidine kinase, cytosolic TK1 0.0052
3191 Histidinol dehydrogenase hisD 0.0052
551 Carnitine O-acetyltransferase CRAT 0.0052
6339 Ig kappa chain V-II region RPMI 6410 Not Available 0.0052
338 DNA polymerase UL30 0.0052
379 DNA polymerase UL54 0.0052
697 DNA polymerase ORF28 0.0052
2482 DNA polymerase 43 0.0052
4104 DNA polymerase BALF5 0.0052
4084 Peptidyl-prolyl cis-trans isomerase B PPIB 0.0052
191 Peptide methionine sulfoxide reductase MSRA 0.0052
5482 Sialidase-2 NEU2 0.0052
712 Tubulin alpha chain TUB1 0.0052
2808 Chloramphenicol acetyltransferase 3 cat3 0.0052
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0052
6837 Serine/threonine-protein kinase 17B STK17B 0.0052
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.0052
909 Maleylacetoacetate isomerase GSTZ1 0.0052
719 Retinoic acid receptor responder protein 1 RARRES1 0.0052
770 Retinoic acid-induced protein 3 GPRC5A 0.0052
4752 Peroxisomal trans-2-enoyl-CoA reductase PECR 0.0052
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0051
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0051
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0051
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0051
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0051
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.005
4109 cAMP-specific 3',5'-cyclic phosphodiesterase 4C PDE4C 0.005
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0049
714 Glutathione reductase, mitochondrial GSR 0.0048
6288 Low molecular weight phosphotyrosine protein phosphatase ACP1 0.0048
3601 Dihydropteroate synthase 1 folP1 0.0047
3807 Dihydropteroate synthase 1 folP1 0.0047
3808 Dihydropteroate synthase 2 folP2 0.0047
2417 Chloramphenicol acetyltransferase cat 0.0047
3278 Chloramphenicol acetyltransferase cat 0.0047
3957 Adenosine deaminase ADA 0.0047
332 Beta-lactamase blaZ 0.0047
2478 Beta-lactamase ampC 0.0047
2613 Beta-lactamase ampC 0.0047
2635 Beta-lactamase ampC 0.0047
2700 Beta-lactamase penP 0.0047
5445 Beta-lactamase blaB 0.0047
6019 Beta-lactamase SHV-7 0.0047
6701 Beta-lactamase cphA 0.0047
2159 Quinone oxidoreductase CRYZ 0.0047
2810 Dr hemagglutinin structural subunit draA 0.0047
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0047
822 Aldose reductase AKR1B1 0.0047
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0046
128 Adenine phosphoribosyltransferase APRT 0.0046
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0046
509 Thymidine kinase TK 0.0046
570 Thymidine kinase TK 0.0046
2559 Thymidine kinase TK 0.0046
3430 Thymidine kinase tdk 0.0046
3518 Thymidine kinase TK 0.0046
5301 Thymidine kinase tdk 0.0046
5771 Thymidine kinase ORF36 0.0046
7009 Thymidine kinase ORF36 0.0046
2599 Tyrosine-protein kinase HCK HCK 0.0046
3014 Ribonuclease UK114 HRSP12 0.0046
3718 Hydrogen peroxide-inducible genes activator oxyR 0.0046
5428 Replication protein repA 0.0046
3617 Non-heme chloroperoxidase cpo 0.0046
5426 Non-heme chloroperoxidase cpo 0.0046
5427 Hydroxyquinol 1,2-dioxygenase chqB 0.0046
3018 HTH-type transcriptional regulator malT malT 0.0046
164 Histamine H4 receptor HRH4 0.0045
992 Protein tyrosine kinase 2 beta PTK2B 0.0045
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.0045
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0045
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0045
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0045
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0045
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0045
4238 50S ribosomal protein L4 rplD 0.0045
5578 50S ribosomal protein L4 rplD 0.0045
6173 50S ribosomal protein L4 rplD 0.0045
6219 50S ribosomal protein L4 rplD 0.0045
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0044
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0044
130 Prostacyclin synthase PTGIS 0.0044
1262 Corticotropin-lipotropin POMC 0.0044
3830 Calreticulin CALR 0.0043
4692 A/G-specific adenine glycosylase mutY 0.0043
268 Adenosine A2b receptor ADORA2B 0.0043
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0043
461 Glycine receptor subunit alpha-3 GLRA3 0.0043
1650 Heme carrier protein 1 SLC46A1 0.0043
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0042
4773 Deoxycytidine kinase DCK 0.0042
3760 Penicillin-binding protein 5 precursor dacA 0.0042
4606 Purine trans deoxyribosylase ptd 0.0042
3729 Citrate synthase gltA 0.0042
4575 Citrate synthase cit 0.0042
4580 Citrate synthase gltA 0.0042
2358 cAMP-specific 3',5'-cyclic phosphodiesterase 4D PDE4D 0.0042
1374 Natriuretic peptides B NPPB 0.0041
1313 Lactoylglutathione lyase GLO1 0.0041
1827 Gap junction alpha-1 protein GJA1 0.0041
1908 Vascular cell adhesion protein 1 VCAM1 0.0041
1176 Mitogen-activated protein kinase 1 MAPK1 0.0041
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0041
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0041
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0041
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0041
6034 Hydroxyindole O-methyltransferase ASMT 0.0041
6035 Nuclear receptor ROR-beta RORB 0.0041
3997 Cytochrome P450 24A1, mitochondrial CYP24A1 0.0041
6036 Eosinophil peroxidase EPX 0.0041
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.004
3679 MTA/SAH nucleosidase mtnN 0.004
1958 S-methyl-5-thioadenosine phosphorylase MTAP 0.004
6184 D-alanyl-D-alanine carboxypeptidase dacC dacC 0.004
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.004
2314 Triosephosphate isomerase TPI 0.004
3417 Triosephosphate isomerase tpiA 0.004
3443 Triosephosphate isomerase tpiA 0.004
6346 Triosephosphate isomerase TPI1 0.004
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.004
775 Acetyl-CoA carboxylase 2 ACACB 0.004
2958 Probable tautomerase ydcE pptA 0.004
2573 Cocaine esterase cocE 0.004
7263 Cocaine esterase Not Available 0.004
866 Large neutral amino acids transporter small subunit 2 SLC7A8 0.004
2236 Casein kinase II subunit alpha CSNK2A1 0.004
2371 Pantothenate kinase coaA 0.0039
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.0039
3115 Ras-related protein Rab-9 RAB9A 0.0039
4146 Phosphatidylinositol 3-kinase regulatory subunit gamma PIK3R3 0.0039
4145 Phosphatidylinositol 3-kinase regulatory subunit beta PIK3R2 0.0039
3603 Chlorocatechol 1,2-dioxygenase clcA 0.0039
1129 C-C chemokine receptor type 5 CCR5 0.0039
2391 Ferrochelatase hemH 0.0039
6502 Ferrochelatase DKFZp686P18130 0.0039
1591 Ferrochelatase, mitochondrial FECH 0.0039
6168 Solute carrier family 22 member 16 SLC22A16 0.0039
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0038
5818 Folate receptor alpha FOLR1 0.0038
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0038
867 Penicillin-binding protein 3 pbpC 0.0038
6119 Penicillin-binding protein 3 pbp3 0.0038
7154 Penicillin-binding protein 3 pbp3 0.0038
7157 Penicillin-binding protein 3 LMHCC_2184 0.0038
7162 Penicillin-binding protein 3 pbpB 0.0038
7172 Penicillin-binding protein 3 pbp3 0.0038
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0038
1063 Signal transducer and activator of transcription 5B STAT5B 0.0038
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0038
85 Growth hormone receptor GHR 0.0038
6103 Arylamine N-acetyltransferase 1 NAT1 0.0037
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0037
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.0037
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.0037
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.0037
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0037
3913 Glutamic acid decarboxylase GAD65 0.0037
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0036
4564 YvbK protein yvbK 0.0036
4567 Putative acyl-CoA thioester hydrolase HI0827 HI_0827 0.0036
4566 Acyl-CoA hydrolase BC_2038 0.0036
4572 Acyl-CoA hydrolase BH0798 0.0036
4576 Aac(6')-Ii protein aac(6')-Ii 0.0036
4577 4'-phosphopantetheinyl transferase sfp sfp 0.0036
2528 Fatty acid metabolism regulator protein fadR 0.0036
6740 Fatty acid metabolism regulator protein fadR 0.0036
4579 Serine acetyltransferase cysE 0.0036
6807 Serine acetyltransferase cysE 0.0036
4037 Hypothetical protein GPX1 0.0036
4297 Hypothetical protein SP_1951 0.0036
4521 Hypothetical protein BC_2969 0.0036
4540 Hypothetical protein TM_1070 0.0036
4555 Hypothetical protein MT1739 0.0036
4569 Hypothetical protein mshD 0.0036
4578 Hypothetical protein PA3270 0.0036
4747 Hypothetical protein PA3967 0.0036
5177 Hypothetical protein TM_0096 0.0036
5194 Hypothetical protein PA1204 0.0036
5240 Hypothetical protein Rv2991 0.0036
5370 Hypothetical protein TM_1158 0.0036
5710 Hypothetical protein Tb927.5.1360 0.0036
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0036
765 Indoleamine 2,3-dioxygenase IDO1 0.0035
185 Vasopressin V1a receptor AVPR1A 0.0035
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0035
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0035
939 50S ribosomal protein L3 rplC 0.0035
322 Vasopressin V2 receptor AVPR2 0.0034
1119 Peroxiredoxin-5, mitochondrial PRDX5 0.0034
6495 Cytochrome c oxidase subunit 7C, mitochondrial COX7C 0.0033
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0033
6499 Cytochrome c oxidase polypeptide 7A1, mitochondrial COX7A1 0.0033
6494 Cytochrome c oxidase subunit 7B, mitochondrial COX7B 0.0033
6496 Cytochrome c oxidase subunit 8A, mitochondrial COX8A 0.0033
6493 Cytochrome c oxidase subunit 6C COX6C 0.0033
6491 Cytochrome c oxidase subunit 5A, mitochondrial COX5A 0.0033
6498 Cytochrome c oxidase subunit 6B1 COX6B1 0.0033
6489 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial COX4I1 0.0033
6497 Cytochrome c oxidase subunit 6A2, mitochondrial COX6A2 0.0033
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.0033
6559 Cytochrome c oxidase subunit 2 ctaC 0.0033
6669 Cytochrome c oxidase subunit 2 ctaC 0.0033
6490 Cytochrome c oxidase subunit 3 MT-CO3 0.0033
371 Cytochrome c oxidase subunit 1 MT-CO1 0.0033
6558 Cytochrome c oxidase subunit 1 ctaD 0.0033
293 Gamma-glutamyl hydrolase GGH 0.0033
1281 Phosphatidylinositol 3-kinase regulatory subunit alpha PIK3R1 0.0033
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0033
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0033
229 Retinoic acid receptor beta RARB 0.0033
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.0033
5328 Prostaglandin F synthase Tb11.02.2310 0.0033
730 Retinoic acid receptor alpha RARA 0.0032
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0032
6048 Troponin C, skeletal muscle TNNC2 0.0032
6105 3-oxo-5-beta-steroid 4-dehydrogenase AKR1D1 0.0032
1864 RET proto-oncogene RET 0.0032
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0032
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0032
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0032
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0032
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0032
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0032
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0032
1770 Phospholipase C PLCL1 0.0032
2841 Phospholipase C plc 0.0032
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0032
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0032
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0032
896 Glutathione S-transferase Mu 1 GSTM1 0.0032
140 30S ribosomal protein S9 rpsI 0.0031
6719 30S ribosomal protein S9 rpsI 0.0031
6725 30S ribosomal protein S9 rpsI 0.0031
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.0031
1636 Trace amine-associated receptor 1 TAAR1 0.0031
3489 Acetyl-coenzyme A synthetase acs 0.0031
2396 Formyl-coenzyme A transferase frc 0.0031
3457 Formyl-coenzyme A transferase frc 0.0031
4574 PROBABLE NAPHTHOATE SYNTHASE MENB menB 0.0031
3024 Crotonobetainyl-CoA:carnitine CoA-transferase caiB 0.0031
2409 Acetyl-CoA acetyltransferase, cytosolic ACAT2 0.0031
4563 Acetyl transferase rimL 0.0031
4565 Aminoglycoside 6'-N-acetyltransferase aac(6')-Iy 0.0031
1227 Cytochrome b MT-CYB 0.0031
6386 Cytochrome b petB 0.0031
6937 Cytochrome b MT-CYB 0.0031
674 Dihydroorotate dehydrogenase homolog, mitochondrial PFF0160c 0.0031
3560 Gentamicin 3'-acetyltransferase aacC1 0.0031
2264 Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase cobT 0.0031
735 Alanine aminotransferase 1 GPT 0.0031
3904 Alanine aminotransferase 2 GPT2 0.0031
2540 Choloylglycine hydrolase cbh 0.0031
484 Tyrosine-protein kinase ABL2 ABL2 0.0031
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0031
3639 Thymidine phosphorylase deoA 0.003
3936 Thymidine phosphorylase TYMP 0.003
2578 Tubulin beta-3 chain TUBB3 0.003
2091 Endoplasmin HSP90B1 0.003
2693 Heat-labile enterotoxin B chain eltB 0.003
4674 2-hydroxy-6-oxo-7-methylocta-2,4-dienoate hydrolase cumD 0.003
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.003
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.003
6163 Copper-transporting ATPase 2 ATP7B 0.003
6165 Copper-transporting ATPase 1 ATP7A 0.003
636 Mitochondrial carnitine/acylcarnitine carrier protein SLC25A20 0.0029
109 Mitochondrial carnitine/acylcarnitine carrier protein CACL SLC25A29 0.0029
6645 D-amino-acid oxidase DAO 0.0029
2216 Fibroblast growth factor receptor 4 FGFR4 0.0029
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0029
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0029
6501 Fatty acid-binding protein, liver FABP1 0.0029
1569 G1/S-specific cyclin-D1 CCND1 0.0029
646 Malate dehydrogenase, cytoplasmic MDH1 0.0029
6824 Tyrosine-protein kinase Lyn LYN 0.0029
4573 Histone acetyltransferase PCAF KAT2B 0.0029
2377 Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex Not Available 0.0029
2560 Galactoside O-acetyltransferase lacA 0.0029
512 DNA-directed RNA polymerase alpha chain rpoA 0.0029
5772 DNA-directed RNA polymerase alpha chain rpoA 0.0029
3199 Phosphopantetheine adenylyltransferase coaD 0.0029
3543 Phosphopantetheine adenylyltransferase coaD 0.0029
3567 Phosphopantetheine adenylyltransferase coaD 0.0029
5289 Phosphopantetheine adenylyltransferase coaD 0.0029
2248 Malate synthase G glcB 0.0028
3190 Malate synthase G glcB 0.0028
3697 Bifunctional protein glmU [Includes: UDP-N-acetylglucosamine pyrophosphorylase glmU 0.0028
3178 Formate acetyltransferase 1 pflB 0.0028
635 Estradiol 17-beta-dehydrogenase 8 HSD17B8 0.0028
666 NADP-dependent malic enzyme ME1 0.0028
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0028
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0028
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0028
1200 AMBP protein AMBP 0.0028
3866 Serum amyloid A protein SAA1 0.0028
1932 Apolipoprotein E APOE 0.0028
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0028
1144 Hepatocyte growth factor receptor MET 0.0027
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0027
4173 Tyrosine-protein kinase JAK2 JAK2 0.0027
4404 FcbC1 protein fcbC 0.0027
1123 Eosinophil cationic protein RNASE3 0.0027
11 NAD(P) transhydrogenase, mitochondrial NNT 0.0027
3849 Insulin-like growth factor-binding protein 7 IGFBP7 0.0027
2009 Protein NOV homolog NOV 0.0027
3847 Neuroendocrine convertase 2 PCSK2 0.0027
1949 Carboxypeptidase E CPE 0.0027
3850 Synaptotagmin-like protein 4 SYTL4 0.0027
3848 Neuroendocrine convertase 1 PCSK1 0.0027
3846 Retinoblastoma-associated protein RB1 0.0027
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0026
291 Nitric-oxide synthase, endothelial NOS3 0.0026
473 L-lactate dehydrogenase A chain LDHA 0.0026
2376 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase dapD 0.0026
6131 Carbonic anhydrase 14 CA14 0.0026
412 Peroxisomal carnitine O-octanoyltransferase CROT 0.0026
5322 Oxidoreductase ydhF ydhF 0.0025
5333 Alcohol dehydrogenase, iron-containing TM_0920 0.0025
3772 3-oxoacyl-[acyl-carrier-protein] reductase fabG 0.0025
5342 NADH-dependent butanol dehydrogenase, putative TM_0820 0.0025
5326 Oxidoreductase, short chain dehydrogenase/reductase family TM_0441 0.0025
5157 Dehydrogenase/reductase SDR family member 11 DHRS11 0.0025
5346 Oxidoreductase, aldo/keto reductase family TM_1009 0.0025
5332 MtdA bifunctional protein mtdA 0.0025
3778 NAD(P) transhydrogenase subunit beta pntB 0.0025
4403 Protein iolS iolS 0.0025
5343 NADP-dependent fatty aldehyde dehydrogenase aldH 0.0025
5330 General stress protein 69 yhdN 0.0025
6033 High affinity interleukin-8 receptor A CXCR1 0.0025
390 Adenosine A3 receptor ADORA3 0.0025
1360 Sphingomyelin phosphodiesterase SMPD1 0.0025
76 Nitric-oxide synthase, brain NOS1 0.0025
686 Aldo-keto reductase family 1 member C2 AKR1C2 0.0024
400 Coagulation factor IX F9 0.0024
5461 Coagulation factor IX F9 0.0024
4484 2,5-diketo-D-gluconic acid reductase A dkgA 0.0024
544 Potassium voltage-gated channel subfamily E member 1 KCNE1 0.0024
2300 Lysozyme E 0.0024
3633 Lysozyme R 0.0024
5597 Lysozyme 17 0.0024
6039 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A PDE11A 0.0024
6122 Carbonic anhydrase 3 CA3 0.0024
615 3-oxoacyl-[acyl-carrier-protein] synthase 3 fabH 0.0024
3138 3-oxoacyl-[acyl-carrier-protein] synthase 3 fabH 0.0024
4568 3-oxoacyl-[acyl-carrier-protein] synthase 3 fabH 0.0024
6370 3-oxoacyl-[acyl-carrier-protein] synthase 3 fabH 0.0024
6500 Phospholipase A2 PLA2G1B 0.0024
6070 Nischarin NISCH 0.0024
233 Potassium channel subfamily K member 2 KCNK2 0.0024
5852 Type-2 angiotensin II receptor AGTR2 0.0024
4388 Aminoglycoside 2'-N-acetyltransferase aac 0.0024
679 C-1-tetrahydrofolate synthase, cytoplasmic MTHFD1 0.0024
4226 Uridine phosphorylase 2 UPP2 0.0023
2596 Acetyl-CoA acetyltransferase phbA 0.0023
550 Amiloride-sensitive sodium channel subunit delta SCNN1D 0.0023
27 Amiloride-sensitive sodium channel subunit beta SCNN1B 0.0023
552 Amiloride-sensitive sodium channel subunit gamma SCNN1G 0.0023
213 Amiloride-sensitive sodium channel subunit alpha SCNN1A 0.0023
1830 5'-nucleotidase NT5E 0.0023
1341 Histamine H3 receptor HRH3 0.0023
654 Flavin reductase BLVRB 0.0023
4081 Vitamin K epoxide reductase complex subunit 1-like protein 1 VKORC1L1 0.0022
604 Vitamin K-dependent protein Z PROZ 0.0022
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0022
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0022
2375 ADP-L-glycero-D-manno-heptose-6-epimerase hldD 0.0022
5073 Ferredoxin--NADP reductase petH 0.0022
5076 Ferredoxin--NADP reductase fpr 0.0022
5119 Ferredoxin--NADP reductase petH 0.0022
5121 Ferredoxin--NADP reductase fpr 0.0022
5075 Sulfite reductase [NADPH] flavoprotein alpha-component cysJ 0.0022
2305 Isocitrate dehydrogenase [NADP] cytoplasmic IDH1 0.0022
3446 NADP-dependent alcohol dehydrogenase adh 0.0022
2286 Isocitrate dehydrogenase [NADP] icd 0.0022
2302 Isocitrate dehydrogenase [NADP] icd 0.0022
2771 Isocitrate dehydrogenase [NADP] icd 0.0022
4582 Putative pteridine reductase 2 ptr2 0.0022
2207 Rhodopsin RHO 0.0022
1799 Glucose-6-phosphate 1-dehydrogenase G6PD 0.0022
2630 Glucose-6-phosphate 1-dehydrogenase zwf 0.0022
4628 NADP-dependent glyceraldehyde-3-phosphate dehydrogenase gapN 0.0022
989 L-xylulose reductase DCXR 0.0022
3404 Exotoxin A eta 0.0022
2155 Insulin-degrading enzyme IDE 0.0022
2232 Interleukin-5 IL5 0.0022
298 Renin REN 0.0021
1593 Mucin-2 MUC2 0.0021
4225 Uridine phosphorylase 1 UPP1 0.0021
2461 D-alanyl-D-alanine carboxypeptidase Not Available 0.0021
5756 D-alanyl-D-alanine carboxypeptidase dac 0.0021
4366 Riboflavin kinase/FMN adenylyltransferase TM_0857 0.0021
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0021
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0021
1244 Low-density lipoprotein receptor-related protein 2 LRP2 0.0021
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0021
1268 Neuropeptide S receptor NPSR1 0.0021
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0021
63 Malate dehydrogenase mdh 0.0021
2329 Malate dehydrogenase mdh 0.0021
3445 Malate dehydrogenase mdh 0.0021
4420 Malate dehydrogenase mdh 0.0021
4438 Malate dehydrogenase mdh 0.0021
828 Phenylalanine-4-hydroxylase PAH 0.0021
3109 Phenylalanine-4-hydroxylase phhA 0.0021
422 Vitamin K-dependent protein C PROC 0.002
1245 Vitamin K-dependent protein S PROS1 0.002
3090 Chitosanase csn 0.002
4149 Nuclear factor NF-kappa-B p100 subunit NFKB2 0.002
3611 Cytidine deaminase cdd 0.002
3707 Cytidine deaminase cdd 0.002
4211 Cytidine deaminase CDA 0.002
6297 Prostaglandin reductase 1 PTGR1 0.002
6862 Aldo-keto reductase family 1 member B10 AKR1B10 0.002
413 Amidophosphoribosyltransferase PPAT 0.002
2515 Amidophosphoribosyltransferase purF 0.002
3714 Amidophosphoribosyltransferase purF 0.002
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.002
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.002
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.002
4531 Putative ketoacyl reductase actIII 0.002
3062 Aspartate-semialdehyde dehydrogenase asd 0.002
5325 2,4-dienoyl-CoA reductase, mitochondrial DECR1 0.002
6218 Pannexin-1 PANX1 0.0019
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0019
1291 cAMP response element-binding protein CREB1 0.0019
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0019
2675 Pteridine reductase 1 PTR1 0.0019
3573 2,4-dienoyl-CoA reductase [NADPH] fadH 0.0019
6073 Potassium channel subfamily K member 9 KCNK9 0.0019
6072 Potassium channel subfamily K member 3 KCNK3 0.0019
2697 Uridine-cytidine kinase 2 UCK2 0.0019
1124 Sepiapterin reductase SPR 0.0019
4992 Cytochrome c peroxidase Not Available 0.0018
627 11-cis retinol dehydrogenase RDH5 0.0018
893 [Citrate [pro-3S]-lyase] ligase citC 0.0018
640 Aldehyde dehydrogenase 1A3 ALDH1A3 0.0018
845 Pyruvate dehydrogenase [cytochrome] poxB 0.0018
1253 Interferon gamma IFNG 0.0018
4210 Toll-like receptor 4 TLR4 0.0018
448 Vitamin K-dependent gamma-carboxylase GGCX 0.0018
1968 ATP-sensitive inward rectifier potassium channel 12 KCNJ12 0.0018
327 Glutathione reductase gor 0.0018
5110 Glutathione reductase GR2 0.0018
5294 Nucleoside diphosphate kinase A NME1 0.0018
683 Potassium transporter GK0582 0.0018
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.0018
857 Malate dehydrogenase, mitochondrial MDH2 0.0018
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.0017
2290 ADP-ribosyl cyclase 2 BST1 0.0017
5288 Shikimate kinase aroK 0.0017
5287 Signaling protein Not Available 0.0017
5314 UPF0079 ATP-binding protein HI0065 HI_0065 0.0017
5293 Shikimate kinase 2 aroL 0.0017
5304 UPF0166 protein TM_0021 TM_0021 0.0017
4346 Polynucleotide kinase pseT 0.0017
5292 Putative partitioning protein TT_C1605 0.0017
5276 Chromosomal replication initiator protein dnaA dnaA 0.0017
5266 Activator of hgdC 0.0017
5259 Transcriptional regulator ntrC1 0.0017
6699 Transcriptional regulator Cgl2612 0.0017
2874 Nitrogenase iron protein 1 nifH1 0.0017
5283 D-alanine--D-alanine ligase B ddlB 0.0017
5281 Plasmid segregation protein parM parM 0.0017
3777 ATP-dependent Clp protease ATP-binding subunit clpA clpA 0.0017
5305 Phosphoribosylaminoimidazole carboxylase ATPase subunit purK 0.0017
5299 D-alanine--D-alanine ligase ddl 0.0017
6598 D-alanine--D-alanine ligase ddl 0.0017
5315 Chaperone protein htpG htpG 0.0017
3982 Phosphoribosylformylglycinamidine synthase PFAS 0.0017
5261 Phosphoribosylformylglycinamidine synthase purL 0.0017
5290 ATP-dependent hsl protease ATP-binding subunit hslU hslU 0.0017
5638 ATP-dependent hsl protease ATP-binding subunit hslU hslU 0.0017
5270 ATP-dependent Clp protease ATP-binding subunit clpX clpX 0.0017
5291 Glycogen synthase 1 glgA1 0.0017
5264 DNA replication protein REP 0.0017
5277 Preprotein translocase subunit secA secA 0.0017
4794 Phosphoenolpyruvate carboxykinase [ATP] pckA 0.0017
5275 Multidrug resistance ABC transporter ATP-binding and permease protein lmrA 0.0017
1549 Heat shock 70 kDa protein 1 HSPA1A 0.0017
5284 Large T antigen Not Available 0.0017
5308 Preprotein translocase secA 1 subunit secA1 0.0017
5285 Kinesin heavy chain KIF5B 0.0017
78 Acetyl-CoA acetyltransferase, mitochondrial ACAT1 0.0016
798 Osteocalcin BGLAP 0.0016
144 Hemoglobin subunit alpha HBA1 0.0016
201 Glutamate dehydrogenase 1, mitochondrial GLUD1 0.0016
1243 Cathepsin D CTSD 0.0016
3007 Carbonic anhydrase 12 CA12 0.0016
4205 Carbonic anhydrase 9 CA9 0.0016
2853 14 kDa fatty acid-binding protein Not Available 0.0015
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0015
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0015
982 Cocaine- and amphetamine-regulated transcript protein CARTPT 0.0015
369 Coagulation factor VII F7 0.0015
3844 HLA class II histocompatibility antigen, DQ(6) alpha chain HLA-DQA2 0.0015
6859 Protein S100-A4 S100A4 0.0014
4106 Guanylate kinase GUK1 0.0013
4516 Guanylate kinase gmk 0.0013
4837 Cag-alfa cag-alfa 0.0013
5682 Ribonuclease pancreatic RNASE1 0.0013
3390 Aminoglycoside 3'-phosphotransferase aphA 0.0013
6029 Aminoglycoside 3'-phosphotransferase aphA1 0.0013
5646 Galactokinase GALK1 0.0013
4838 PMS1 protein homolog 2 PMS2 0.0013
4839 DNA polymerase III subunit tau dnaX 0.0013
5302 TrwB trwB 0.0013
5265 FtsH ftsH 0.0013
5189 Trimethylamine dehydrogenase tmd 0.0013
4774 NTPase P4 Not Available 0.0013
6277 Heat shock cognate 71 kDa protein HSPA8 0.0013
2270 Dephospho-CoA kinase coaE 0.0013
2284 Adenylate kinase adk 0.0013
2296 Adenylate kinase adk 0.0013
2311 Adenylate kinase adk 0.0013
2312 Adenylate kinase Not Available 0.0013
3470 Hypothetical protein MG245 homolog MPN_348 0.0013
3175 Glutamate--cysteine ligase gshA 0.0013
3426 Glutamine synthetase glnA 0.0013
3987 Glutamine synthetase GLUL 0.0013
2751 Holliday junction ATP-dependent DNA helicase ruvB ruvB 0.0013
4755 Holliday junction ATP-dependent DNA helicase ruvB ruvB 0.0013
5295 2-keto-3-deoxy-gluconate kinase TT_P0036 0.0013
561 Retinol-binding protein II, cellular RBP2 0.0013
35 Dehydrogenase/reductase SDR family member 4 DHRS4 0.0013
4073 Retinol dehydrogenase 11 RDH11 0.0013
4074 Retinol dehydrogenase 14 RDH14 0.0013
1097 Lecithin retinol acyltransferase LRAT 0.0013
589 Retinoid-binding protein 7 RBP7 0.0013
753 Retinol-binding protein III, cellular RBP5 0.0013
4071 Short-chain dehydrogenase/reductase 3 DHRS3 0.0013
4075 Photoreceptor outer segment all-trans retinol dehydrogenase RDH8 0.0013
863 Cellular retinaldehyde-binding protein RLBP1 0.0013
800 Retinol dehydrogenase 12 RDH12 0.0013
282 Interphotoreceptor retinoid-binding protein RBP3 0.0013
651 Retinol dehydrogenase 13 RDH13 0.0013
4072 All-trans-retinol 13,14-reductase RETSAT 0.0013
6211 Tubulin epsilon chain TUBE1 0.0013
6212 Tubulin gamma-1 chain TUBG1 0.0013
6210 Tubulin delta chain TUBD1 0.0013
3087 Nicotinate-nucleotide adenylyltransferase nadD 0.0013
4469 Nicotinate-nucleotide adenylyltransferase nadD 0.0013
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0013
5626 Nucleoside diphosphate kinase B NME2 0.0013
2683 Mono-ADP-ribosyltransferase C3 C3 0.0013
6116 Gastric triacylglycerol lipase LIPF 0.0012
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0012
5590 N utilization substance protein B homolog nusB 0.0012
340 Apoptotic protease-activating factor 1 APAF1 0.0012
5598 Glycerol uptake operon antiterminator-related protein TM_1436 0.0012
5586 Pleckstrin homology domain-containing family A member 1 PLEKHA1 0.0012
5577 N5-carboxyaminoimidazole ribonucleotide mutase purE 0.0012
3792 KHG/KDPG aldolase [Includes: 4-hydroxy-2-oxoglutarate aldolase eda 0.0012
2838 Ribose-5-phosphate isomerase A rpiA 0.0012
2952 Ribose-5-phosphate isomerase A rpiA 0.0012
5595 Ribose-5-phosphate isomerase A rpiA 0.0012
4695 UPF0124 protein yfiH yfiH 0.0012
5060 Intron-associated endonuclease 1 ITEVIR 0.0012
5593 Transferase Not Available 0.0012
5588 Cell division protein FtsY TM_0570 0.0012
5591 Complement component C8 gamma chain C8G 0.0012
5587 Iron(III)-binding periplasmic protein fbpA 0.0012
5583 RNA 3'-terminal phosphate cyclase rtcA 0.0012
5582 Regulator of transcription; stringent starvation protein A sspA 0.0012
5592 Ribonucleoside-diphosphate reductase subunit beta nrdF 0.0012
5581 Beta-fructosidase bfrA 0.0012
5600 Pyruvate decarboxylase pdc 0.0012
4375 Glutamine synthetase 1 glnA1 0.0012
5575 Short tail fiber protein 12 0.0012
5580 Hexon protein PII 0.0012
5574 Invasin YPTB1668 0.0012
3823 Cytokine receptor common gamma chain IL2RG 0.0012
2107 Microtubule-associated protein 1A MAP1A 0.0012
997 Protein kinase C beta type PRKCB 0.0012
4948 Cytochrome c-553 Not Available 0.0012
4923 Cytochrome c3 DvMF_2499 0.0012
4945 Cytochrome c3 Not Available 0.0012
4949 Cytochrome c3 DVU_3171 0.0012
4968 Cytochrome c3 cytc3 0.0012
4997 Cytochrome c3 SO_2727 0.0012
5219 Cytochrome c3 cyd 0.0012
1295 Fatty acid synthase FASN 0.0012
4902 Nine-heme cytochrome c Ddes_2038 0.0012
3189 High-molecular-weight cytochrome c hmcA 0.0012
2390 Nonsecretory ribonuclease RNASE2 0.0012
5312 Kinesin-like protein KIF1A KIF1A 0.0012
2922 Glycerol kinase glpK 0.0012
5271 Focal adhesion kinase 1 PTK2 0.0012
5433 UPF0230 protein TM_1468 TM_1468 0.0012
5431 Lipid binding protein Not Available 0.0012
3616 Fatty acid-binding protein, epidermal FABP5 0.0012
5430 Hepatocyte nuclear factor 4-gamma HNF4G 0.0012
331 Retinol-binding protein I, cellular RBP1 0.0012
2282 Protein recA recA 0.0011
2315 Protein recA recA 0.0011
2332 Protein recA recA 0.0011
5263 Protein recA recA 0.0011
408 Riboflavin kinase RFK 0.0011
1970 Protein kinase C alpha type PRKCA 0.0011
754 Pancreatic triacylglycerol lipase PNLIP 0.0011
2615 Chemotaxis protein cheA cheA 0.0011
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0011
1881 Hexokinase-1 HK1 0.0011
2950 Inositol-trisphosphate 3-kinase A ITPKA 0.0011
1467 Tumor necrosis factor ligand superfamily member 13B TNFSF13B 0.0011
2892 Acetylglutamate kinase argB 0.0011
3550 Acetylglutamate kinase argB 0.0011
3669 Ribokinase rbsK 0.0011
6857 [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 2, mitochondrial PDK2 0.0011
825 Arsenical pump-driving ATPase ASNA1 0.0011
3435 Arsenical pump-driving ATPase arsA 0.0011
3132 Tryptophan synthase alpha chain trpA 0.0011
6568 Tryptophan synthase alpha chain trpA 0.0011
2408 Tyrosine-protein kinase SYK SYK 0.0011
5006 RNASE4 protein RNASE4 0.0011
2555 Pol polyprotein pol 0.0011
3242 Pol polyprotein gag-pol 0.0011
3471 Pol polyprotein gag-pro-pol 0.0011
5256 Pol polyprotein pol 0.0011
6469 Pol polyprotein gag-pol 0.0011
6565 Pol polyprotein Not Available 0.0011
3085 Molybdopterin-guanine dinucleotide biosynthesis protein A mobA 0.0011
4533 Glyoxalase family protein BC_1747 0.0011
2178 Metabotropic glutamate receptor 5 GRM5 0.0011
724 Interleukin-2 receptor alpha chain IL2RA 0.0011
717 Interleukin-2 receptor subunit beta IL2RB 0.0011
355 GMP synthase [glutamine-hydrolyzing] GMPS 0.0011
4353 GMP synthase [glutamine-hydrolyzing] guaA 0.0011
788 Creatine kinase M-type CKM 0.001
1810 Protein S100-A1 S100A1 0.001
6097 Protein S100-A2 S100A2 0.001
2727 S-adenosylmethionine synthetase metK 0.001
6390 Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 ATP2A1 0.001
4386 Hemoglobin-like protein HbN glbN 0.001
493 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial CYP27B1 0.001
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.001
2334 Dethiobiotin synthetase bioD 0.001
6555 Dethiobiotin synthetase bioD 0.001
283 SEC14-like protein 2 SEC14L2 0.001
2817 Phosphoribosylglycinamide formyltransferase 2 purT 0.001
345 Plasma retinol-binding protein RBP4 0.001
4041 Microsomal glutathione S-transferase 2 MGST2 0.001
4373 Medium-chain-fatty-acid--CoA ligase Not Available 0.001
2603 Beta-lactamase II blm 0.001
2521 Cell division protein ftsZ ftsZ 0.001
3301 Cell division protein ftsZ ftsZ 0.001
2149 Angiogenin ANG 0.001
3583 6-phosphogluconolactonase pgl 0.001
810 Heme oxygenase 1 HMOX1 0.001
3391 Heme oxygenase 1 pbsA1 0.001
453 S-adenosylmethionine synthetase isoform type-1 MAT1A 0.001
2298 Cytochrome P450-cam camC 0.001
61 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.001
2644 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.001
2710 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.001
2268 Cholesterol oxidase choB 0.0009
2822 Cholesterol oxidase choA 0.0009
5432 Trafficking protein particle complex subunit 3 TRAPPC3 0.0009
2211 Fatty acid-binding protein, heart FABP3 0.0009
6459 Glycodelin PAEP 0.0009
941 Betaine--homocysteine S-methyltransferase 1 BHMT 0.0009
2942 Sialidase nanH 0.0009
3546 Sialidase nedA 0.0009
3486 Fumarate hydratase class II fumC 0.0009
2511 MAP kinase-activated protein kinase 2 MAPKAPK2 0.0009
2869 1-deoxy-D-xylulose 5-phosphate reductoisomerase dxr 0.0009
1064 DNA (cytosine-5)-methyltransferase 1 DNMT1 0.0009
3221 Cytochrome c4 cc4 0.0009
2452 Tryptophanyl-tRNA synthetase trpS 0.0009
702 UMP-CMP kinase CMPK1 0.0009
2317 UDP-N-acetylmuramoylalanine--D-glutamate ligase murD 0.0009
1048 Protein S100-A13 S100A13 0.0009
207 Glutathione synthetase GSS 0.0009
5269 Glutathione synthetase gshB 0.0009
2226 Protein S100-A12 S100A12 0.0009
6395 Myosin-14 MYH14 0.0009
2251 Thymidylate kinase tmk 0.0009
2254 Thymidylate kinase DTYMK 0.0009
3522 Thymidylate kinase tmk 0.0009
6677 Myelin P2 protein PMP2 0.0009
2805 Heparan sulfate glucosamine 3-O-sulfotransferase 3A1 HS3ST3A1 0.0009
816 Biliverdin reductase A BLVRA 0.0009
579 Alcohol dehydrogenase class 4 mu/sigma chain ADH7 0.0009
2283 Steroid Delta-isomerase ksi 0.0009
2920 Steroid Delta-isomerase ksi 0.0009
316 4-trimethylaminobutyraldehyde dehydrogenase ALDH9A1 0.0009
792 Aldehyde dehydrogenase, dimeric NADP-preferring ALDH3A1 0.0009
2936 Oxygen-insensitive NAD(P)H nitroreductase nfnB 0.0009
5184 Oxygen-insensitive NAD(P)H nitroreductase nfnB 0.0009
1422 Serine/threonine-protein kinase 6 AURKA 0.0009
411 Glycine N-methyltransferase GNMT 0.0009
2132 Protein S100-B S100B 0.0009
3379 Kinesin-like protein KIF11 KIF11 0.0008
219 NADH-ubiquinone oxidoreductase chain 3 MT-ND3 0.0008
343 NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial NDUFC1 0.0008
236 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 NDUFA6 0.0008
755 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 NDUFA3 0.0008
353 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 NDUFA4L2 0.0008
300 NADH-ubiquinone oxidoreductase chain 4L MT-ND4L 0.0008
374 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 NDUFB1 0.0008
475 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial NDUFB2 0.0008
99 NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 NDUFS5 0.0008
30 NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial NDUFV3 0.0008
446 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 NDUFA7 0.0008
525 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 NDUFA5 0.0008
270 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial NDUFB5 0.0008
104 NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial NDUFS6 0.0008
247 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 NDUFA1 0.0008
417 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 NDUFB6 0.0008
324 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 NDUFB4 0.0008
598 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 NDUFA11 0.0008
582 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 NDUFA13 0.0008
190 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4 NDUFA4 0.0008
602 Acyl carrier protein, mitochondrial NDUFAB1 0.0008
609 15-hydroxyprostaglandin dehydrogenase [NAD+] HPGD 0.0008
405 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 NDUFA8 0.0008
313 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 NDUFB3 0.0008
384 NADH-ubiquinone oxidoreductase chain 6 MT-ND6 0.0008
607 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 NDUFA2 0.0008
555 NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial NDUFS4 0.0008
656 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 NDUFB9 0.0008
746 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial NDUFB8 0.0008
644 Heme oxygenase 2 HMOX2 0.0008
4982 Heme oxygenase 2 pbsA2 0.0008
41 NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial NDUFS8 0.0008
50 Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating NSDHL 0.0008
335 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial NDUFA9 0.0008
568 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 NDUFB7 0.0008
216 Aldehyde dehydrogenase 3B2 ALDH3B2 0.0008
9 Estradiol 17-beta-dehydrogenase 2 HSD17B2 0.0008
152 NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial NDUFV2 0.0008
829 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 NDUFA12 0.0008
145 Corticosteroid 11-beta-dehydrogenase isozyme 2 HSD11B2 0.0008
721 NADH-ubiquinone oxidoreductase chain 2 MT-ND2 0.0008
91 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial NDUFA10 0.0008
107 C-4 methylsterol oxidase SC4MOL 0.0008
608 NADH-ubiquinone oxidoreductase chain 4 MT-ND4 0.0008
539 NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial NDUFV1 0.0008
496 Aldehyde dehydrogenase 3B1 ALDH3B1 0.0008
272 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 NDUFB10 0.0008
372 Estradiol 17-beta-dehydrogenase 3 HSD17B3 0.0008
729 GDP-L-fucose synthetase TSTA3 0.0008
3463 GDP-L-fucose synthetase fcl 0.0008
487 Aldo-keto reductase family 1 member C4 AKR1C4 0.0008
167 L-lactate dehydrogenase C chain LDHC 0.0008
326 L-lactate dehydrogenase A-like 6A LDHAL6A 0.0008
141 3-hydroxyisobutyrate dehydrogenase, mitochondrial HIBADH 0.0008
180 D-3-phosphoglycerate dehydrogenase PHGDH 0.0008
3726 D-3-phosphoglycerate dehydrogenase serA 0.0008
4291 D-3-phosphoglycerate dehydrogenase serA 0.0008
206 3-keto-steroid reductase HSD17B7 0.0008
258 Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial ALDH6A1 0.0008
196 D-beta-hydroxybutyrate dehydrogenase, mitochondrial BDH1 0.0008
231 Glycerol-3-phosphate dehydrogenase [NAD+], cytoplasmic GPD1 0.0008
271 Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial ALDH4A1 0.0008
14 Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial IDH3A 0.0008
112 L-lactate dehydrogenase A-like 6B LDHAL6B 0.0008
616 Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial IDH3B 0.0008
671 Pyruvate dehydrogenase E1 component alpha subunit, testis-specific form, mitochondrial PDHA2 0.0008
628 Pyruvate dehydrogenase E1 component alpha subunit, somatic form, mitochondrial PDHA1 0.0008
848 Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial IDH3G 0.0008
34 7-dehydrocholesterol reductase DHCR7 0.0008
662 Fatty aldehyde dehydrogenase ALDH3A2 0.0008
288 Trifunctional enzyme subunit alpha, mitochondrial HADHA 0.0008
711 UDP-glucose 6-dehydrogenase UGDH 0.0008
3672 UDP-glucose 6-dehydrogenase hasB 0.0008
531 Aldehyde dehydrogenase X, mitochondrial ALDH1B1 0.0008
637 NADH-ubiquinone oxidoreductase chain 5 MT-ND5 0.0008
149 Alpha-aminoadipic semialdehyde dehydrogenase ALDH7A1 0.0008
643 Peroxisomal bifunctional enzyme EHHADH 0.0008
548 NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial NDUFS1 0.0008
393 GDH/6PGL endoplasmic bifunctional protein [Includes: Glucose 1-dehydrogenase H6PD 0.0008
22 30S ribosomal protein S4 rpsD 0.0008
6714 30S ribosomal protein S4 rpsD 0.0008
3456 Heat shock protein HSP 90-beta HSP90AB1 0.0008
2325 Sulfotransferase family cytosolic 2B member 1 SULT2B1 0.0008
5579 Carboxypeptidase B CPB1 0.0008
3822 Actin, alpha skeletal muscle ACTA1 0.0008
4954 Soluble cytochrome b558 Not Available 0.0008
4925 Cytochrome c-type protein SHP shp 0.0008
4916 Cyanoglobin glbN 0.0008
4947 Bacterial hemoglobin vhb 0.0008
4915 Cytochrome c-550 psbV 0.0008
4959 Cytochrome c-550 psbV 0.0008
5216 Cytochrome c-550 psbV 0.0008
4934 Cytochrome c-551 nirM 0.0008
5218 Cytochrome c-551 nirM 0.0008
4943 Cytochrome c6 petJ 0.0008
4975 Cytochrome c-556 RPA3973 0.0008
4936 Cytochrome c2 iso-2 Not Available 0.0008
4994 Hemoglobin-like protein HbO glbO 0.0008
4905 Cytochrome c2 Not Available 0.0008
4939 Cytochrome c2 cycA 0.0008
4964 Cytochrome c2 cycA 0.0008
4979 Cytochrome c2 cycA 0.0008
6673 Cytochrome c2 cycA 0.0008
4984 Neuroglobin NGB 0.0008
4998 Hemoglobin-like protein yjbI yjbI 0.0008
3116 Bacterioferritin bfr 0.0008
4906 Bacterioferritin bfr 0.0008
4965 Bacterioferritin bfr 0.0008
5000 HemO hemO 0.0008
4910 Cytoglobin CYGB 0.0008
4909 CooA protein cooA 0.0008
4981 Iron-starvation protein PigA pigA 0.0008
4907 Cytochrome c-L moxG 0.0008
6865 Cytochrome c-L moxG 0.0008
4942 Diheme cytochrome c napB napB 0.0008
4935 Cytochrome c-554 cycA1 0.0008
4961 Hemophore HasA hasA 0.0008
4904 Cytochrome c family protein GSU1996 0.0008
3478 Glucose-1-phosphate thymidylyltransferase rmlA 0.0008
4277 Glucose-1-phosphate thymidylyltransferase rmlA 0.0008
4971 Nonaheme cytochrome c hmcA 0.0008
4976 Apocytochrome f petA 0.0008
6407 Apocytochrome f petA 0.0008
4764 Cytochrome P450 165C4 CYP165C4 0.0008
4999 Cytochrome P450 165B3 CYP165B3 0.0008
4960 Putative cytochrome P450-family protein SCO7417 0.0008
4931 Cytochrome P450 167A1 CYP167A1 0.0008
4989 Cytochrome c551 peroxidase ccp 0.0008
5222 Cytochrome c551 peroxidase ccpA 0.0008
4937 Cytochrome oxidase subunit II rcoxA 0.0008
4972 P450cin cinA 0.0008
4903 Methyl-accepting chemotaxis protein Tar4 0.0008
4926 Heme-based aerotactic transducer hemAT hemAT 0.0008
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0008
4922 Cytochrome c, putative SO_4144 0.0008
4993 Hydroxylamine oxidoreductase hao1 0.0008
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0008
3093 Catalase HPII katE 0.0008
4952 Catalase/peroxidase katA 0.0008
3384 Macrophage migration inhibitory factor MIF 0.0008
178 NADH-cytochrome b5 reductase 3 CYB5R3 0.0008
812 Dihydrolipoyl dehydrogenase, mitochondrial DLD 0.0008
350 3-hydroxyacyl-CoA dehydrogenase type-2 HSD17B10 0.0008
454 Peroxisomal multifunctional enzyme type 2 HSD17B4 0.0008
396 Alcohol dehydrogenase 4 ADH4 0.0008
363 NADP-dependent malic enzyme, mitochondrial ME3 0.0008
328 Sorbitol dehydrogenase SORD 0.0008
597 Dihydropteridine reductase QDPR 0.0008
1867 Major prion protein PRNP 0.0008
1507 Cytochrome c CYCS 0.0008
4031 Glutathione S-transferase A1 GSTA1 0.0008
1649 Small inducible cytokine A2 CCL2 0.0008
419 Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial HADH 0.0008
1025 Aquaporin-1 AQP1 0.0008
830 Glutamate dehydrogenase 2, mitochondrial GLUD2 0.0008
12 Alcohol dehydrogenase class 3 ADH5 0.0008
839 Short-chain specific acyl-CoA dehydrogenase, mitochondrial ACADS 0.0008
77 L-lactate dehydrogenase B chain LDHB 0.0008
1721 Glycogen synthase kinase-3 beta GSK3B 0.0008
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.0007
74 Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial DLAT 0.0007
599 Glyceraldehyde-3-phosphate dehydrogenase GAPDH 0.0007
4426 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0007
4454 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0007
4489 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0007
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.0007
794 Glyceraldehyde-3-phosphate dehydrogenase, testis-specific GAPDHS 0.0007
248 Pyrroline-5-carboxylate reductase 1 PYCR1 0.0007
802 Pyrroline-5-carboxylate reductase 2 PYCR2 0.0007
626 Cysteine dioxygenase type 1 CDO1 0.0007
296 Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial MTHFD2 0.0007
110 Pyruvate dehydrogenase E1 component subunit beta, mitochondrial PDHB 0.0007
13 Aminomethyltransferase, mitochondrial AMT 0.0007
6228 Nuclear receptor coactivator 1 NCOA1 0.0007
6207 30S ribosomal protein S14 rpsN 0.0007
6209 30S ribosomal protein S19 rpsS 0.0007
6712 30S ribosomal protein S19 rpsS 0.0007
6726 30S ribosomal protein S19 rpsS 0.0007
166 NAD-dependent malic enzyme, mitochondrial ME2 0.0007
6134 Sodium channel subunit beta-3 SCN3B 0.0007
6133 Sodium channel subunit beta-2 SCN2B 0.0007
6135 Sodium channel subunit beta-4 SCN4B 0.0007
6241 Nuclear receptor coactivator 2 NCOA2 0.0007
6132 Sodium channel subunit beta-1 SCN1B 0.0007
6129 Carbonic anhydrase-related protein 11 CA11 0.0007
6127 Carbonic anhydrase-related protein CA8 0.0007
6128 Carbonic anhydrase-related protein 10 CA10 0.0007
83 Alpha-aminoadipic semialdehyde synthase, mitochondrial AASS 0.0007
226 Gonadotropin-releasing hormone receptor GNRHR 0.0007
125 DNA polymerase beta POLB 0.0007
57 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I HSD3B1 0.0006
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0006
279 Tyrosinase TYR 0.0006
6130 Carbonic anhydrase 13 CA13 0.0006
4920 Peroxidase/catalase katG 0.0006
2119 Cytochrome b5 CYB5A 0.0006
4990 PpcA ppcA 0.0006
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0006
3375 Acidic cytochrome c3 Not Available 0.0006
4988 Sulfite oxidase, mitochondrial SUOX 0.0006
2915 Sensor protein fixL fixL 0.0006
4944 Sensor protein fixL fixL 0.0006
4385 Cytochrome c' Not Available 0.0006
4967 Cytochrome c' cycA 0.0006
5038 Cytochrome c' Not Available 0.0006
5223 Cytochrome c' cycP 0.0006
3570 Cytochrome P450 152A1 cypC 0.0006
4813 Heme oxygenase hmuO 0.0006
5769 Heme oxygenase Not Available 0.0006
4289 Cytochrome P450 TT_P0059 0.0006
6262 Cytochrome P450 staP 0.0006
2230 Catalase CAT 0.0006
3249 Catalase katA 0.0006
3625 Catalase katA 0.0006
4539 Catalase katA 0.0006
4941 Catalase katB 0.0006
5221 Cytochrome c3, 13 kDa Not Available 0.0006
3152 Cytochrome c'' cycA 0.0006
5220 Split-Soret cytochrome c Ddes_2150 0.0006
3700 Cytochrome c-552 precursor nrfA 0.0006
3411 Cytochrome P450 121 cyp121 0.0005
3670 Soluble cytochrome b562 precursor cybC 0.0005
3291 Cytochrome c-552 cycA 0.0005
4927 Cytochrome c-552 nrfA 0.0005
4938 Cytochrome c-552 cycA 0.0005
4953 Cytochrome c-552 nrfA 0.0005
5217 Cytochrome c-552 cycM 0.0005
2617 Nitric oxide synthase oxygenase nos 0.0005
2701 Nitric oxide synthase oxygenase nos 0.0005
3102 Flavohemoprotein hmp 0.0005
4969 Flavohemoprotein hmp 0.0005
3127 Nitrite reductase nirS 0.0005
3284 Nitrite reductase nirS 0.0005
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0005
2972 6-deoxyerythronolide B hydroxylase eryF 0.0005
4608 Putative cytochrome P450 SCO1207 0.0004
4963 Putative cytochrome P450 SCO2884 0.0004
6254 Putative cytochrome P450 SCO6998 0.0004
3405 Quinohaemoprotein ethanol dehydrogenase type-1 qheDH 0.0004
358 Cystathionine beta-synthase CBS 0.0004
693 Hemoglobin subunit beta HBB 0.0004
6268 Hydroxyacid oxidase 1 HAO1 0.0004
2240 Cell division protein kinase 2 CDK2 0.0003
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