DT-Web

DB00912 - Repaglinide


Identification
Name Repaglinide
Accession Number DB00912 (APRD00439)
Type small molecule
Description Repaglinide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the meglitinide class of short-acting insulin secretagogues, which act by binding to ? cells of the pancreas to stimulate insulin release. Repaglinide induces an early insulin response to meals decreasing postprandial blood glucose levels. It should only be taken with meals and meal-time doses should be skipped with any skipped meal. Approximately one month of therapy is required before a decrease in fasting blood glucose is seen. Meglitnides may have a neutral effect on weight or cause a slight increase in weight. The average weight gain caused by meglitinides appears to be lower than that caused by sulfonylureas and insulin and appears to occur only in those na?ve to oral antidiabetic agents. Due to their mechanism of action, meglitinides may cause hypoglycemia although the risk is thought to be lower than that of sulfonylureas since their action is dependent on the presence of glucose. In addition to reducing postprandial and fasting blood glucose, meglitnides have been shown to decrease glycosylated hemoglobin (HbA1c) levels, which are reflective of the last 8-10 weeks of glucose control. Meglitinides appear to be more effective at lowering postprandial blood glucose than metformin, sulfonylureas and thiazolidinediones. Repaglinide is extensively metabolized in the liver and excreted in bile. Repaglinide metabolites do not possess appreciable hypoglycemic activity. Approximately 90% of a single orally administered dose is eliminated in feces and 8% in urine.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 452.5857
Groups approved
Monoisotopic Weight 452.26750765
Pharmacology
Indication As an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.
Mechanism of action Repaglinide activity is dependent on the presence functioning β cells and glucose. In contrast to sulfonylurea insulin secretatogogues, repaglinide has no effect on insulin release in the absence of glucose. Rather, it potentiates the effect of extracellular glucose on ATP-sensitive potassium channel and has little effect on insulin levels between meals and overnight. As such, repaglinide is more effective at reducing postprandial blood glucose levels than fasting blood glucose levels and requires a longer duration of therapy (approximately one month) before decreases in fasting blood glucose are observed. The insulinotropic effects of repaglinide are highest at intermediate glucose levels (3 to 10 mmol/L) and it does not increase insulin release already stimulated by high glucose concentrations (greater than 15 mmol/L). Repaglinide appears to be selective for pancreatic β cells and does not appear to affect skeletal or cardiac muscle or thyroid tissue.
Absorption Rapidly and completely absorbed following oral administration. Peak plasma concentrations are observed within 1 hour (range 0.5-1.4 hours). The absolute bioavailability is approximately 56%. Maximal biological effect is observed within 3-3.5 hours and plasma insulin levels remain elevated for 4-6 hours. When a single 2 mg dose of repaglinide is given to healthy subjects, the area under the curve (AUC) is 18.0 - 18.7 (ng/mL/h)^3.
Protein binding >98% (e.g. to to albumin and α1-acid glycoprotein)
Biotransformation Repaglinide is rapidly metabolized via oxidation and dealkylation by cytochrome P450 3A4 and 2C9 to form the major dicarboxylic acid derivative (M2). Further oxidation produces the aromatic amine derivative (M1). Glucuronidation of the carboxylic acid group of repaglinide yields an acyl glucuronide (M7). Several other unidentified metabolites have been detected. Repaglinide metabolites to not possess appreciable hypoglycemic activity.
Route of elimination 90% eliminated in feces (<2% as unchanged drug), 8% in urine (0.1% as unchanged drug)
Toxicity LD50 >1 g/kg (rat) (W. Grell)
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Acebutolol Acebutolol may decrease symptoms of hypoglycemia and increase the time required for the body to compensate for hypoglycemia.
Atenolol The beta-blocker, atenolol, may decrease symptoms of hypoglycemia.
Betaxolol The beta-blocker, betaxolol, may decrease symptoms of hypoglycemia.
Bevantolol The beta-blocker, bevantolol, may decrease symptoms of hypoglycemia.
Bisoprolol The beta-blocker, bisoprolol, may decrease symptoms of hypoglycemia.
Carteolol The beta-blocker, carteolol, may decrease symptoms of hypoglycemia.
Carvedilol The beta-blocker, carvedilol, may decrease symptoms of hypoglycemia.
Clarithromycin Clarithromycin may increase the effect of repaglinide.
Cyclosporine Cyclosporine may increase the therapeutic and adverse effects of repaglinide.
Erythromycin The macrolide, erythromycin, may increase the effect of repaglinide.
Esmolol The beta-blocker, esmolol, may decrease symptoms of hypoglycemia.
Fluvastatin Inhibitors of CYP3A4 and P-glycoprotein may increase serum concentrations of repaglinide. Monitor concomitant therapy closely.
Gemfibrozil Gemfibrozil may increase the effect and toxicity of repaglinide.
Glucosamine Possible hyperglycemia
Josamycin The macrolide, josamycin, may increase the effect of repaglinide.
Labetalol The beta-blocker, labetalol, may decrease symptoms of hypoglycemia.
Metoprolol The beta-blocker, metoprolol, may decrease symptoms of hypoglycemia.
Nadolol The beta-blocker, nadolol, may decrease symptoms of hypoglycemia.
Oxprenolol The beta-blocker, oxprenolol, may decrease symptoms of hypoglycemia.
Penbutolol The beta-blocker, penbutolol, may decrease symptoms of hypoglycemia.
Pindolol The beta-blocker, pindolol, may decrease symptoms of hypoglycemia.
Practolol The beta-blocker, practolol, may decrease symptoms of hypoglycemia.
Pravastatin Substrates of organic anion transporters may increase levels of repaglinide. Monitor concomitant therapy closely.
Propranolol The beta-blocker, propranolol, may decrease symptoms of hypoglycemia.
Rifampin Rifampin decreases the effect of repaglinide
Sotalol The beta-blocker, sotalol, may decrease symptoms of hypoglycemia.
Telithromycin Telithromycin may reduce clearance of Repaglinide. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Repaglinide if Telithromycin is initiated, discontinued or dose changed.
Timolol The beta-blocker, timolol, may decrease symptoms of hypoglycemia.
Voriconazole Voriconazole, a strong CYP3A4 inhibitor, may increase the serum concentration of repaglinide by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of repaglinide if voriconazole is initiated, discontinued or dose changed.
Food Interactions
  • Take up to 30 minutes before meals.
  • When taken with a high-fat meal, AUC and Cmax decreases.

Targets


ATP-binding cassette transporter sub-family C member 8
Name ATP-binding cassette transporter sub-family C member 8
Gene Name ABCC8
Pharmacological action yes
Actions inhibitor
References
  • Hu S, Wang S, Fanelli B, Bell PA, Dunning BE, Geisse S, Schmitz R, Boettcher BR: Pancreatic beta-cell K(ATP) channel activity and membrane-binding studies with nateglinide: A comparison with sulfonylureas and repaglinide. J Pharmacol Exp Ther. 2000 May;293(2):444-52. - Pubmed
  • Sunaga Y, Gonoi T, Shibasaki T, Ichikawa K, Kusama H, Yano H, Seino S: The effects of mitiglinide (KAD-1229), a new anti-diabetic drug, on ATP-sensitive K+ channels and insulin secretion: comparison with the sulfonylureas and nateglinide. Eur J Pharmacol. 2001 Nov 9;431(1):119-25. - Pubmed
  • Hansen AM, Christensen IT, Hansen JB, Carr RD, Ashcroft FM, Wahl P: Differential interactions of nateglinide and repaglinide on the human beta-cell sulphonylurea receptor 1. Diabetes. 2002 Sep;51(9):2789-95. - Pubmed
  • Wangler B, Schneider S, Thews O, Schirrmacher E, Comagic S, Feilen P, Schwanstecher C, Schwanstecher M, Shiue CY, Alavi A, Hohnemann S, Piel M, Rosch F, Schirrmacher R: Synthesis and evaluation of (S)-2-(2-[18F]fluoroethoxy)-4-([3-methyl-1-(2-piperidin-1-yl-phenyl)-butyl -carbamoyl]-methyl)-benzoic acid ([18F]repaglinide): a promising radioligand for quantification of pancreatic beta-cell mass with positron emission tomography (PET). Nucl Med Biol. 2004 Jul;31(5):639-47. - Pubmed
  • Wangler B, Beck C, Shiue CY, Schneider S, Schwanstecher C, Schwanstecher M, Feilen PJ, Alavi A, Rosch F, Schirrmacher R: Synthesis and in vitro evaluation of (S)-2-([11C]methoxy)-4-[3-methyl-1-(2-piperidine-1-yl-phenyl)-butyl-carbam oyl]-benzoic acid ([11C]methoxy-repaglinide): a potential beta-cell imaging agent. Bioorg Med Chem Lett. 2004 Oct 18;14(20):5205-9. - Pubmed
  • Dornhorst A: Insulinotropic meglitinide analogues. Lancet. 2001 Nov 17;358(9294):1709-16. - Pubmed
DTHybrid score 0.3538
Peroxisome proliferator-activated receptor gamma
Name Peroxisome proliferator-activated receptor gamma
Gene Name PPARG
Pharmacological action unknown
Actions agonist
References
  • Scarsi M, Podvinec M, Roth A, Hug H, Kersten S, Albrecht H, Schwede T, Meyer UA, Rucker C: Sulfonylureas and glinides exhibit peroxisome proliferator-activated receptor gamma activity: a combined virtual screening and biological assay approach. Mol Pharmacol. 2007 Feb;71(2):398-406. Epub 2006 Nov 2. - Pubmed
DTHybrid score 1.0024

Enzymes


Cytochrome P450 3A4
Name Cytochrome P450 3A4
Gene Name CYP3A4
Actions substrate,inhibitor
References
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
  • Bidstrup TB, Bjornsdottir I, Sidelmann UG, Thomsen MS, Hansen KT: CYP2C8 and CYP3A4 are the principal enzymes involved in the human in vitro biotransformation of the insulin secretagogue repaglinide. Br J Clin Pharmacol. 2003 Sep;56(3):305-14. - Pubmed
DTHybrid score 0.4137
Cytochrome P450 2C8
Name Cytochrome P450 2C8
Gene Name CYP2C8
Actions substrate
References
  • Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
  • Bidstrup TB, Bjornsdottir I, Sidelmann UG, Thomsen MS, Hansen KT: CYP2C8 and CYP3A4 are the principal enzymes involved in the human in vitro biotransformation of the insulin secretagogue repaglinide. Br J Clin Pharmacol. 2003 Sep;56(3):305-14. - Pubmed
DTHybrid score 0.2522

Transporters


Solute carrier organic anion transporter family member 1B1
Name Solute carrier organic anion transporter family member 1B1
Gene Name SLCO1B1
Actions substrate
References
  • He J, Qiu Z, Li N, Yu Y, Lu Y, Han D, Li T, Zhao D, Sun W, Fang F, Zheng J, Fan H, Chen X: Effects of SLCO1B1 polymorphisms on the pharmacokinetics and pharmacodynamics of repaglinide in healthy Chinese volunteers. Eur J Clin Pharmacol. 2011 Jul;67(7):701-7. doi: 10.1007/s00228-011-0994-7. Epub 2011 Feb 17. - Pubmed
DTHybrid score 0.2237

Carriers


Solute carrier organic anion transporter family member 1B1
Name Solute carrier organic anion transporter family member 1B1
Gene Name SLCO1B1
Actions
References Not Available
DTHybrid score 0.2237

Predictions


Id Partner name Gene Name Score
4757 Cytochrome P450 2C9 CYP2C9 0.242
6016 Cytochrome P450 2C19 CYP2C19 0.1673
1588 Multidrug resistance protein 1 ABCB1 0.166
4119 Cytochrome P450 2D6 CYP2D6 0.1373
4118 Cytochrome P450 3A5 CYP3A5 0.1216
4200 Cytochrome P450 1A2 CYP1A2 0.1106
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0949
20 Prostaglandin G/H synthase 1 PTGS1 0.0934
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0873
6107 Cytochrome P450 3A7 CYP3A7 0.0823
1729 Solute carrier family 22 member 6 SLC22A6 0.0817
6030 Cytochrome P450 2B6 CYP2B6 0.0815
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0797
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0754
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0696
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0616
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.061
6013 Cytochrome P450 2E1 CYP2E1 0.0586
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0574
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0569
290 Prostaglandin G/H synthase 2 PTGS2 0.0517
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0516
6024 Cytochrome P450 1A1 CYP1A1 0.0504
6228 Nuclear receptor coactivator 1 NCOA1 0.0465
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0461
6142 Solute carrier family 22 member 8 SLC22A8 0.0433
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0424
862 Multidrug resistance-associated protein 1 ABCC1 0.0421
5718 Cytochrome P450 2A6 CYP2A6 0.0389
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0387
2164 Multidrug resistance-associated protein 4 ABCC4 0.0379
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0366
6106 Cytochrome P450 2C18 CYP2C18 0.0331
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.033
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0327
459 Retinoic acid receptor RXR-alpha RXRA 0.0321
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0302
776 Bile salt export pump ABCB11 0.0294
183 Vascular endothelial growth factor A VEGFA 0.0291
6145 Solute carrier family 22 member 1 SLC22A1 0.0286
1024 Solute carrier family 22 member 11 SLC22A11 0.0284
6241 Nuclear receptor coactivator 2 NCOA2 0.028
70 Type-1 angiotensin II receptor AGTR1 0.0275
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0265
6143 Solute carrier family 22 member 7 SLC22A7 0.0264
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0264
275 Arachidonate 5-lipoxygenase ALOX5 0.0261
891 Dihydropteroate synthase folP 0.025
5359 Dihydropteroate synthase folP 0.025
7175 Dihydropteroate synthase sulI 0.025
3811 Cytochrome P450 19A1 CYP19A1 0.0241
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0229
871 Glucocorticoid receptor NR3C1 0.0228
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0223
136 Estrogen receptor ESR1 0.0218
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0214
492 Histamine H1 receptor HRH1 0.0212
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0208
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0208
6141 Sodium/bile acid cotransporter SLC10A1 0.0195
502 5-hydroxytryptamine 2A receptor HTR2A 0.019
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0189
731 HIV-1 protease HIV-1 protease 0.0186
1898 Cytochrome P450 1B1 CYP1B1 0.0186
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0186
738 Monocarboxylate transporter 1 SLC16A1 0.0181
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0171
1389 Transforming growth factor beta-1 TGFB1 0.0169
118 Organic cation/carnitine transporter 2 SLC22A5 0.0166
831 D(2) dopamine receptor DRD2 0.0162
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0162
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.016
824 Sodium-dependent serotonin transporter SLC6A4 0.0159
320 5-hydroxytryptamine 1A receptor HTR1A 0.0155
847 Mu-type opioid receptor OPRM1 0.0152
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0148
556 Alpha-1A adrenergic receptor ADRA1A 0.0148
4604 Liver carboxylesterase 1 CES1 0.0147
758 Thyroid hormone receptor alpha THRA 0.0146
6541 Peptostreptococcal albumin-binding protein pab 0.0142
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0136
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0135
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0135
6144 Solute carrier family 22 member 2 SLC22A2 0.0135
23 D(1A) dopamine receptor DRD1 0.0132
467 Delta-type opioid receptor OPRD1 0.0131
346 Thyroid hormone receptor beta-1 THRB 0.013
696 Kappa-type opioid receptor OPRK1 0.0128
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0125
373 Transthyretin TTR 0.0123
703 NADPH azoreductase azr 0.0122
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0118
833 Organic cation/carnitine transporter 1 SLC22A4 0.0118
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0118
3587 Gastrotropin FABP6 0.0118
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0117
594 Thyroxine-binding globulin SERPINA7 0.0116
5880 Thrombopoietin receptor MPL 0.0114
756 Sex hormone-binding globulin SHBG 0.0114
6085 Fatty acid-binding protein, intestinal FABP2 0.0112
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0112
632 Alpha-1B adrenergic receptor ADRA1B 0.0111
2183 Fatty acid-binding protein, adipocyte FABP4 0.0108
2211 Fatty acid-binding protein, heart FABP3 0.0108
468 Cytochrome P450 4A11 CYP4A11 0.0105
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0104
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0103
29 Tubulin beta-1 chain TUBB1 0.0102
318 Alpha-2A adrenergic receptor ADRA2A 0.0102
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0101
146 Androgen receptor AR 0.0101
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.01
6031 Cytochrome P450 3A43 CYP3A43 0.01
614 Progesterone receptor PGR 0.0097
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0097
6148 Multidrug resistance-associated protein 7 ABCC10 0.0097
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0097
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0097
844 Epidermal growth factor receptor EGFR 0.0096
1757 Myeloperoxidase MPO 0.0096
566 Serotransferrin TF 0.0094
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0094
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0094
4148 Serine/threonine-protein kinase mTOR MTOR 0.0094
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0094
26 Vascular endothelial growth factor receptor 3 FLT4 0.0093
811 Translocator protein TSPO 0.0093
260 Cytochrome P450 51 ERG11 0.0092
761 Cytochrome P450 51 ERG11 0.0092
3163 Cytochrome P450 51 cyp51 0.0092
6136 Multidrug resistance-associated protein 5 ABCC5 0.0091
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0091
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0091
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0089
32 Vascular endothelial growth factor receptor 1 FLT1 0.0089
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0088
407 Vascular endothelial growth factor receptor 2 KDR 0.0088
6147 Solute carrier family 22 member 3 SLC22A3 0.0087
3923 Cholinesterase BCHE 0.0086
122 P2Y purinoceptor 12 P2RY12 0.0085
705 Glutamate receptor 1 GRIA1 0.0085
33 Cystine/glutamate transporter SLC7A11 0.0084
6182 Cytochrome P450 2J2 CYP2J2 0.0083
590 5-hydroxytryptamine 2C receptor HTR2C 0.0083
885 5-hydroxytryptamine 1B receptor HTR1B 0.0081
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0081
232 Corticosteroid-binding globulin SERPINA6 0.008
6525 Group IID secretory phospholipase A2 PLA2G2D 0.008
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.008
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.008
504 Mast/stem cell growth factor receptor KIT 0.0079
725 5-hydroxytryptamine 1D receptor HTR1D 0.0079
6102 Arylamine N-acetyltransferase 2 NAT2 0.0079
645 Penicillin-binding protein 1A mrcA 0.0078
5805 Penicillin-binding protein 1A ponA 0.0078
6185 Penicillin-binding protein 1A mrcA 0.0078
6799 Penicillin-binding protein 1A pbpA 0.0078
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0078
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0077
869 Estrogen receptor beta ESR2 0.0077
3941 Amine oxidase [flavin-containing] A MAOA 0.0077
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0076
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0075
6043 Putative G-protein coupled receptor 44 GPR44 0.0075
341 5-hydroxytryptamine 3 receptor HTR3A 0.0074
952 Dipeptidyl peptidase 4 DPP4 0.0074
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0074
768 FK506-binding protein 1A FKBP1A 0.0074
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0073
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0073
537 ATP synthase delta chain, mitochondrial ATP5D 0.0073
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0072
543 Penicillin-binding protein 1B mrcB 0.0072
6186 Penicillin-binding protein 1B ponB 0.0072
6822 Penicillin-binding protein 1b pbp1b 0.0072
6844 Penicillin-binding protein 1b pbp1b 0.0072
482 Glycine receptor subunit alpha-1 GLRA1 0.0072
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0072
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0072
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0072
199 Monocarboxylate transporter 8 SLC16A2 0.0072
1 Peptidoglycan synthetase ftsI ftsI 0.0071
4155 Peptidoglycan synthetase ftsI ftsI 0.0071
2539 Tubulin alpha-1 chain TUBA4A 0.007
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.007
380 Cytochrome P450 17A1 CYP17A1 0.0069
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0068
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0068
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0068
789 Alpha-1D adrenergic receptor ADRA1D 0.0068
6167 Organic solute transporter subunit beta OSTB 0.0066
6166 Organic solute transporter subunit alpha OSTA 0.0066
36 Insulin receptor INSR 0.0066
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0066
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0065
766 Beta-2 adrenergic receptor ADRB2 0.0064
465 Calmodulin CALM1 0.0064
3809 Estrogen-related receptor gamma ESRRG 0.0064
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0064
6137 Multidrug resistance-associated protein 6 ABCC6 0.0063
1119 Peroxiredoxin-5, mitochondrial PRDX5 0.0063
3312 Fatty acid-binding protein, brain FABP7 0.0062
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0062
3932 Glutathione S-transferase A2 GSTA2 0.0061
558 Solute carrier family 12 member 1 SLC12A1 0.0061
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0061
1525 Heparin-binding growth factor 2 FGF2 0.0061
1650 Heme carrier protein 1 SLC46A1 0.0061
6020 Aldehyde oxidase AOX1 0.0061
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.006
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.006
1050 Bile salt sulfotransferase SULT2A1 0.006
713 Sodium-dependent dopamine transporter SLC6A3 0.006
228 Beta platelet-derived growth factor receptor PDGFRB 0.0059
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.0059
818 50S ribosomal protein L10 rplJ 0.0058
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0057
365 Dihydrofolate reductase DHFR 0.0057
2381 Dihydrofolate reductase DFR1 0.0057
2833 Dihydrofolate reductase Not Available 0.0057
2931 Dihydrofolate reductase folA 0.0057
3544 Dihydrofolate reductase folA 0.0057
3682 Dihydrofolate reductase folA 0.0057
6642 Dihydrofolate reductase folA 0.0057
6756 Dihydrofolate reductase dfrA 0.0057
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0056
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0056
629 Alpha-2B adrenergic receptor ADRA2B 0.0056
638 D(3) dopamine receptor DRD3 0.0055
78 Acetyl-CoA acetyltransferase, mitochondrial ACAT1 0.0055
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0055
759 Free fatty acid receptor 1 FFAR1 0.0054
88 Retinoic acid receptor RXR-beta RXRB 0.0054
1818 Long-chain-fatty-acid--CoA ligase 3 ACSL3 0.0054
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0053
378 Alpha-2C adrenergic receptor ADRA2C 0.0053
2853 14 kDa fatty acid-binding protein Not Available 0.0053
267 Plasminogen activator inhibitor 1 SERPINE1 0.0053
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0052
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0052
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0051
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0051
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0051
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0051
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0051
6221 Steroid hormone receptor ERR1 ESRRA 0.0051
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0051
3856 Fibroblast growth factor receptor 3 FGFR3 0.005
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.005
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.005
606 Cytochrome P450 27, mitochondrial CYP27A1 0.005
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.005
6027 Alkaline phosphatase, tissue-nonspecific isozyme ALPL 0.005
1541 Metalloproteinase mmp20 0.0049
340 Apoptotic protease-activating factor 1 APAF1 0.0049
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0048
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0048
6184 D-alanyl-D-alanine carboxypeptidase dacC dacC 0.0048
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0048
24 Thymidylate synthase TMP1 0.0048
359 Thymidylate synthase TYMS 0.0048
2626 Thymidylate synthase thyA 0.0048
2729 Thymidylate synthase thyA 0.0048
5352 Thymidylate synthase THYA 0.0048
737 Mineralocorticoid receptor NR3C2 0.0047
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0047
6103 Arylamine N-acetyltransferase 1 NAT1 0.0047
1053 BC269730_2 FADS1 0.0047
1395 Sodium/calcium exchanger 1 SLC8A1 0.0047
436 5-hydroxytryptamine 2B receptor HTR2B 0.0046
3382 Glycolipid transfer protein GLTP 0.0046
284 DNA-directed RNA polymerase beta chain rpoB 0.0046
5773 DNA-directed RNA polymerase beta chain rpoB 0.0046
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0045
193 Beta-1 adrenergic receptor ADRB1 0.0045
2021 Thrombomodulin THBD 0.0045
161 Tubulin beta chain TUBB 0.0044
312 Tubulin beta chain TUB2 0.0044
115 Penicillin-binding protein 2 mrdA 0.0044
6069 Penicillin-binding protein 2 mrdA 0.0044
6118 Penicillin-binding protein 2 penA 0.0044
6187 Penicillin-binding protein 2 pbpA 0.0044
6686 Penicillin-binding protein 2 pbp2 0.0044
6939 Penicillin-binding protein 2 mrdA 0.0044
7163 Penicillin-binding protein 2 pbpA 0.0044
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0044
563 Thyroid peroxidase TPO 0.0044
162 Retinoic acid receptor gamma-1 RARG 0.0044
6151 Monocarboxylate transporter 10 SLC16A10 0.0044
6149 Solute carrier family 22 member 10 SLC22A10 0.0044
2178 Metabotropic glutamate receptor 5 GRM5 0.0044
1558 Transient receptor potential cation channel subfamily V member 1 TRPV1 0.0044
4122 Histone deacetylase 2 HDAC2 0.0044
5645 DNA topoisomerase 4 subunit B parE 0.0044
6227 DNA topoisomerase 4 subunit B parE 0.0044
887 DNA gyrase subunit B gyrB 0.0044
4150 DNA gyrase subunit B gyrB 0.0044
6225 DNA gyrase subunit B gyrB 0.0044
825 Arsenical pump-driving ATPase ASNA1 0.0043
3435 Arsenical pump-driving ATPase arsA 0.0043
2105 ATP-binding cassette sub-family G member 1 ABCG1 0.0043
510 Serine/threonine-protein kinase receptor R3 ACVRL1 0.0043
733 Activin receptor type 1B ACVR1B 0.0043
745 Anti-Muellerian hormone type-2 receptor AMHR2 0.0043
486 Serine/threonine-protein kinase ALS2CR7 CDK15 0.0043
483 A-Raf proto-oncogene serine/threonine-protein kinase ARAF 0.0043
21 Beta-adrenergic receptor kinase 2 ADRBK2 0.0043
377 Beta-adrenergic receptor kinase 1 ADRBK1 0.0043
154 AFG3-like protein 2 AFG3L2 0.0043
225 NEDD8-activating enzyme E1 regulatory subunit NAE1 0.0043
395 ALK tyrosine kinase receptor Not Available 0.0043
856 Vitamin D3 receptor VDR 0.0043
633 Penicillin-binding proteins 1A/1B pbpA 0.0043
273 Apoptosis regulator Bcl-2 BCL2 0.0043
817 DNA topoisomerase 2-alpha TOP2A 0.0042
814 Ryanodine receptor 1 RYR1 0.0042
5787 Angiopoietin-1 receptor TEK 0.0042
6220 Aryl hydrocarbon receptor AHR 0.0041
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0041
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0041
3947 Xanthine dehydrogenase/oxidase XDH 0.0041
6677 Myelin P2 protein PMP2 0.0041
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0041
229 Retinoic acid receptor beta RARB 0.0041
3997 Cytochrome P450 24A1, mitochondrial CYP24A1 0.0041
1353 DNA topoisomerase 1 TOP1 0.0041
3552 DNA topoisomerase 1 topA 0.0041
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.004
6508 Putative uncharacterized protein srtB 0.004
6543 Putative uncharacterized protein tcp14 0.004
6615 Putative uncharacterized protein MT0785 0.004
6623 Putative uncharacterized protein Not Available 0.004
6806 Putative uncharacterized protein AGR_C_2535 0.004
6813 Putative uncharacterized protein SAV4671 0.004
6815 Putative uncharacterized protein AFE_1514 0.004
6819 Putative uncharacterized protein RUMGNA_03254 0.004
6825 Putative uncharacterized protein CV_3270 0.004
4161 Furin FURIN 0.004
730 Retinoic acid receptor alpha RARA 0.004
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.004
4120 NADPH--cytochrome P450 reductase POR 0.004
4210 Toll-like receptor 4 TLR4 0.0039
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0039
1129 C-C chemokine receptor type 5 CCR5 0.0039
484 Tyrosine-protein kinase ABL2 ABL2 0.0038
6067 Penicillin binding protein 2a mecA 0.0038
1630 Integrin beta-2 ITGB2 0.0038
292 Activin receptor type-1 ACVR1 0.0038
849 Activated CDC42 kinase 1 TNK2 0.0038
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0038
704 Long-chain-fatty-acid--CoA ligase 1 ACSL1 0.0038
297 Adenylate cyclase type 1 ADCY1 0.0038
821 Acetyl-coenzyme A synthetase 2-like, mitochondrial ACSS1 0.0038
386 Acetyl-coenzyme A synthetase, cytoplasmic ACSS2 0.0038
511 5-hydroxytryptamine 1F receptor HTR1F 0.0038
289 Cytosolic purine 5'-nucleotidase NT5C2 0.0038
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0037
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0037
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0037
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0037
777 Tumor necrosis factor TNF 0.0037
1760 Aminopeptidase N ANPEP 0.0037
6843 Aminopeptidase N pepN 0.0037
432 D(4) dopamine receptor DRD4 0.0037
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0037
6014 Cytochrome P450 2A13 CYP2A13 0.0037
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0036
1291 cAMP response element-binding protein CREB1 0.0036
716 5-hydroxytryptamine 7 receptor HTR7 0.0036
68 Cannabinoid receptor 1 CNR1 0.0036
819 Penicillin-binding protein 4 dacB 0.0036
117 Sterol O-acyltransferase 1 SOAT1 0.0036
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0035
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0035
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.0035
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0035
4237 50S ribosomal protein L22 rplV 0.0035
4116 Dihydropteroate synthetase Not Available 0.0035
185 Vasopressin V1a receptor AVPR1A 0.0035
780 Retinoic acid receptor RXR-gamma RXRG 0.0035
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0035
939 50S ribosomal protein L3 rplC 0.0035
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0035
1656 CYP2B protein CYP2B 0.0034
1992 Vitamin D-binding protein GC 0.0034
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.0034
322 Vasopressin V2 receptor AVPR2 0.0034
1483 Membrane copper amine oxidase AOC3 0.0034
1010 Cytochrome P450 51A1 CYP51A1 0.0034
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0034
5300 Antigen peptide transporter 1 TAP1 0.0034
357 Carbonic anhydrase 2 CA2 0.0034
474 Acetylcholinesterase ACHE 0.0033
596 3-oxo-5-alpha-steroid 4-dehydrogenase 1 SRD5A1 0.0033
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0033
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0033
2981 Phospholipase A2, membrane associated PLA2G2A 0.0033
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0033
6033 High affinity interleukin-8 receptor A CXCR1 0.0033
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0033
740 Argininosuccinate synthase ASS1 0.0032
865 Argininosuccinate synthase ASS1 0.0032
2680 Argininosuccinate synthase argG 0.0032
3194 Argininosuccinate synthase argG 0.0032
1792 Tissue-type plasminogen activator PLAT 0.0032
1867 Major prion protein PRNP 0.0032
592 Carbonic anhydrase 4 CA4 0.0032
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0032
3939 Amine oxidase [flavin-containing] B MAOB 0.0032
595 Fibrinogen alpha chain FGA 0.0032
140 30S ribosomal protein S9 rpsI 0.0031
6719 30S ribosomal protein S9 rpsI 0.0031
6725 30S ribosomal protein S9 rpsI 0.0031
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0031
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0031
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0031
295 Carbonic anhydrase 1 CA1 0.0031
6044 Serum paraoxonase/lactonase 3 PON3 0.0031
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0031
3086 Plasmepsin-2 Not Available 0.0031
3760 Penicillin-binding protein 5 precursor dacA 0.0031
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0031
1648 Elastin ELN 0.0031
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0031
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0031
427 Substance-P receptor TACR1 0.0031
242 Asparagine synthetase [glutamine-hydrolyzing] ASNS 0.0031
6501 Fatty acid-binding protein, liver FABP1 0.003
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.003
2578 Tubulin beta-3 chain TUBB3 0.003
2285 Streptogramin A acetyltransferase vatD 0.003
6021 Adenosine kinase ADK 0.003
4203 Histamine N-methyltransferase HNMT 0.003
94 5-hydroxytryptamine 4 receptor HTR4 0.003
6042 Prostaglandin reductase 2 PTGR2 0.003
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.003
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.003
1629 Transcription factor AP-1 JUN 0.003
1618 High affinity nerve growth factor receptor NTRK1 0.003
208 DNA-directed RNA polymerase beta' chain rpoC 0.003
5774 DNA-directed RNA polymerase beta' chain rpoC 0.003
636 Mitochondrial carnitine/acylcarnitine carrier protein SLC25A20 0.0029
109 Mitochondrial carnitine/acylcarnitine carrier protein CACL SLC25A29 0.0029
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0029
3813 Fibrinogen gamma chain FGG 0.0029
3812 Fibrinogen beta chain [Contains: Fibrinopeptide B] FGB 0.0029
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0029
661 ADP/ATP translocase 1 SLC25A4 0.0029
6138 Multidrug resistance protein 3 ABCB4 0.0029
572 Integrin alpha-L ITGAL 0.0029
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0029
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0029
233 Potassium channel subfamily K member 2 KCNK2 0.0028
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0028
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0028
1517 Beta-3 adrenergic receptor ADRB3 0.0028
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0028
6168 Solute carrier family 22 member 16 SLC22A16 0.0028
6207 30S ribosomal protein S14 rpsN 0.0028
6209 30S ribosomal protein S19 rpsS 0.0028
6712 30S ribosomal protein S19 rpsS 0.0028
6726 30S ribosomal protein S19 rpsS 0.0028
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0028
5431 Lipid binding protein Not Available 0.0028
3616 Fatty acid-binding protein, epidermal FABP5 0.0028
5433 UPF0230 protein TM_1468 TM_1468 0.0028
1278 Pro-epidermal growth factor EGF 0.0028
5430 Hepatocyte nuclear factor 4-gamma HNF4G 0.0028
723 Cytosolic phospholipase A2 PLA2G4A 0.0027
3917 Methylenetetrahydrofolate reductase MTHFR 0.0027
5934 Cytochrome P450 26A1 CYP26A1 0.0027
4173 Tyrosine-protein kinase JAK2 JAK2 0.0027
889 3-oxoacyl-[acyl-carrier-protein] synthase 1 fabB 0.0027
6860 3-oxoacyl-[acyl-carrier-protein] synthase 1 kasA 0.0027
904 Glutathione S-transferase P GSTP1 0.0026
760 Fibroblast growth factor 1 FGF1 0.0026
5432 Trafficking protein particle complex subunit 3 TRAPPC3 0.0026
16 Adenosine A1 receptor ADORA1 0.0026
921 Glutamate receptor 2 GRIA2 0.0026
581 Cytochrome P450 2R1 CYP2R1 0.0026
49 Endothelin B receptor EDNRB 0.0026
412 Peroxisomal carnitine O-octanoyltransferase CROT 0.0026
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0025
551 Carnitine O-acetyltransferase CRAT 0.0025
4252 Penicillin-binding protein 5 dacA 0.0025
2207 Rhodopsin RHO 0.0025
1178 Adenosine A2a receptor ADORA2A 0.0025
518 Peroxidase/catalase T katG 0.0025
4217 Telomerase reverse transcriptase TERT 0.0025
3426 Glutamine synthetase glnA 0.0025
3987 Glutamine synthetase GLUL 0.0025
163 D(1B) dopamine receptor DRD5 0.0024
751 Potassium channel subfamily K member 6 KCNK6 0.0024
578 Endothelin-1 receptor EDNRA 0.0024
1256 5-hydroxytryptamine 6 receptor HTR6 0.0024
544 Potassium voltage-gated channel subfamily E member 1 KCNE1 0.0024
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0024
159 Penicillin-binding protein 2B penA 0.0024
6121 Penicillin-binding protein 2B penA 0.0024
6039 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A PDE11A 0.0024
1313 Lactoylglutathione lyase GLO1 0.0024
2112 Toll-like receptor 9 TLR9 0.0024
6231 Pepsin A PGA3 0.0024
5852 Type-2 angiotensin II receptor AGTR2 0.0024
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0024
642 3-oxo-5-alpha-steroid 4-dehydrogenase 2 SRD5A2 0.0023
283 SEC14-like protein 2 SEC14L2 0.0023
469 Annexin A1 ANXA1 0.0023
332 Beta-lactamase blaZ 0.0023
2478 Beta-lactamase ampC 0.0023
2613 Beta-lactamase ampC 0.0023
2635 Beta-lactamase ampC 0.0023
2700 Beta-lactamase penP 0.0023
5445 Beta-lactamase blaB 0.0023
6019 Beta-lactamase SHV-7 0.0023
6701 Beta-lactamase cphA 0.0023
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0023
3810 Catechol O-methyltransferase COMT 0.0023
1852 Microtubule-associated protein 2 MAP2 0.0023
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0022
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0022
124 Histamine H2 receptor HRH2 0.0022
4311 tRNA TRDMT1 0.0022
4325 tRNA trmD 0.0022
4328 tRNA trmD 0.0022
172 Potassium channel subfamily K member 1 KCNK1 0.0022
6459 Glycodelin PAEP 0.0022
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0022
1714 Mitogen-activated protein kinase 3 MAPK3 0.0022
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0022
2449 Tubulin alpha-3 chain TUBA1A 0.0021
298 Renin REN 0.0021
6506 Stathmin-4 STMN4 0.0021
165 FL cytokine receptor FLT3 0.0021
707 72 kDa type IV collagenase MMP2 0.0021
4226 Uridine phosphorylase 2 UPP2 0.0021
6174 50S ribosomal protein L32 rpmF 0.0021
5818 Folate receptor alpha FOLR1 0.0021
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0021
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.0021
244 Angiotensin-converting enzyme ACE 0.0021
1196 Complement decay-accelerating factor CD55 0.0021
331 Retinol-binding protein I, cellular RBP1 0.0021
6432 Transporter snf 0.002
239 Coagulation factor X F10 0.002
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.002
3937 Fatty-acid amide hydrolase FAAH 0.002
2320 Thymidine kinase, cytosolic TK1 0.002
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.002
4225 Uridine phosphorylase 1 UPP1 0.002
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.002
2499 Tubulin beta-2C chain TUBB2C 0.0019
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0019
528 5-hydroxytryptamine 1E receptor HTR1E 0.0019
634 Squalene monooxygenase SQLE 0.0019
7196 Squalene monooxygenase ERG1 0.0019
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0019
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0019
477 DNA topoisomerase 4 subunit A parC 0.0019
886 DNA topoisomerase 4 subunit A parC 0.0019
6226 DNA topoisomerase 4 subunit A parC 0.0019
65 Matrix metalloproteinase-9 Not Available 0.0018
293 Gamma-glutamyl hydrolase GGH 0.0018
404 DNA gyrase subunit A gyrA 0.0018
6224 DNA gyrase subunit A gyrA 0.0018
413 Amidophosphoribosyltransferase PPAT 0.0018
2515 Amidophosphoribosyltransferase purF 0.0018
3714 Amidophosphoribosyltransferase purF 0.0018
2808 Chloramphenicol acetyltransferase 3 cat3 0.0018
5998 Toll-like receptor 8 TLR8 0.0018
1262 Corticotropin-lipotropin POMC 0.0018
84 Nuclear receptor 0B1 NR0B1 0.0018
4238 50S ribosomal protein L4 rplD 0.0018
5578 50S ribosomal protein L4 rplD 0.0018
6173 50S ribosomal protein L4 rplD 0.0018
6219 50S ribosomal protein L4 rplD 0.0018
712 Tubulin alpha chain TUB1 0.0018
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0018
1968 ATP-sensitive inward rectifier potassium channel 12 KCNJ12 0.0018
565 Extracellular calcium-sensing receptor CASR 0.0018
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0018
1192 Sulfotransferase 1A1 SULT1A1 0.0018
683 Potassium transporter GK0582 0.0018
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0018
1198 Serum paraoxonase/arylesterase 1 PON1 0.0018
6223 Penicillin-binding protein 1C pbpC 0.0018
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0017
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0017
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.0017
613 Atrial natriuretic peptide receptor A NPR1 0.0017
6218 Pannexin-1 PANX1 0.0017
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0017
823 Fibroblast growth factor receptor 2 FGFR2 0.0017
489 Monocarboxylate transporter 2 SLC16A7 0.0017
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0017
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0017
6824 Tyrosine-protein kinase Lyn LYN 0.0017
2417 Chloramphenicol acetyltransferase cat 0.0017
3278 Chloramphenicol acetyltransferase cat 0.0017
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0017
3601 Dihydropteroate synthase 1 folP1 0.0017
3807 Dihydropteroate synthase 1 folP1 0.0017
3808 Dihydropteroate synthase 2 folP2 0.0017
2810 Dr hemagglutinin structural subunit draA 0.0016
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0016
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0016
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0016
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0016
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0016
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0016
173 Toll-like receptor 7 TLR7 0.0016
3913 Glutamic acid decarboxylase GAD65 0.0016
3233 Bile acid receptor NR1H4 0.0015
3639 Thymidine phosphorylase deoA 0.0015
3936 Thymidine phosphorylase TYMP 0.0015
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0015
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0015
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0015
319 Opioid receptor, sigma 1 OPRS1 0.0015
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0014
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0014
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0014
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0014
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0014
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0014
5923 Microtubule-associated protein tau MAPT 0.0014
5924 Microtubule-associated protein 4 MAP4 0.0014
2599 Tyrosine-protein kinase HCK HCK 0.0014
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.0014
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0014
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0014
976 Platelet glycoprotein IX GP9 0.0014
4103 Proteasome subunit beta type 2 PSMB2 0.0014
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0014
4102 Proteasome subunit beta type 5 PSMB5 0.0014
4101 Proteasome subunit beta type 1 PSMB1 0.0014
2391 Ferrochelatase hemH 0.0014
6502 Ferrochelatase DKFZp686P18130 0.0014
1591 Ferrochelatase, mitochondrial FECH 0.0014
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0014
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0013
2216 Fibroblast growth factor receptor 4 FGFR4 0.0013
735 Alanine aminotransferase 1 GPT 0.0013
3904 Alanine aminotransferase 2 GPT2 0.0013
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0013
6146 High affinity copper uptake protein 1 SLC31A1 0.0013
605 Fumarate reductase flavoprotein subunit frdA 0.0013
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0013
3673 Fumarate reductase flavoprotein subunit fccA 0.0013
4912 Fumarate reductase flavoprotein subunit ifcA 0.0013
6549 Fumarate reductase flavoprotein subunit frdA 0.0013
1405 Thiopurine S-methyltransferase TPMT 0.0013
6116 Gastric triacylglycerol lipase LIPF 0.0012
4192 DNA topoisomerase 2-beta TOP2B 0.0012
822 Aldose reductase AKR1B1 0.0012
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0012
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0012
174 Sigma 1-type opioid receptor SIGMAR1 0.0012
3823 Cytokine receptor common gamma chain IL2RG 0.0012
85 Growth hormone receptor GHR 0.0012
6126 Carbonic anhydrase 7 CA7 0.0012
2107 Microtubule-associated protein 1A MAP1A 0.0012
571 Melatonin receptor type 1A MTNR1A 0.0012
362 Melatonin receptor type 1B MTNR1B 0.0012
338 DNA polymerase UL30 0.0012
379 DNA polymerase UL54 0.0012
697 DNA polymerase ORF28 0.0012
2482 DNA polymerase 43 0.0012
4104 DNA polymerase BALF5 0.0012
1864 RET proto-oncogene RET 0.0012
6048 Troponin C, skeletal muscle TNNC2 0.0012
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0012
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0012
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0012
1295 Fatty acid synthase FASN 0.0012
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0012
6495 Cytochrome c oxidase subunit 7C, mitochondrial COX7C 0.0012
6499 Cytochrome c oxidase polypeptide 7A1, mitochondrial COX7A1 0.0012
6496 Cytochrome c oxidase subunit 8A, mitochondrial COX8A 0.0012
6493 Cytochrome c oxidase subunit 6C COX6C 0.0012
6494 Cytochrome c oxidase subunit 7B, mitochondrial COX7B 0.0012
6491 Cytochrome c oxidase subunit 5A, mitochondrial COX5A 0.0012
6498 Cytochrome c oxidase subunit 6B1 COX6B1 0.0012
6489 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial COX4I1 0.0012
6497 Cytochrome c oxidase subunit 6A2, mitochondrial COX6A2 0.0012
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.0012
6559 Cytochrome c oxidase subunit 2 ctaC 0.0012
6669 Cytochrome c oxidase subunit 2 ctaC 0.0012
6490 Cytochrome c oxidase subunit 3 MT-CO3 0.0012
371 Cytochrome c oxidase subunit 1 MT-CO1 0.0012
6558 Cytochrome c oxidase subunit 1 ctaD 0.0012
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0012
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0012
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0012
719 Retinoic acid receptor responder protein 1 RARRES1 0.0012
770 Retinoic acid-induced protein 3 GPRC5A 0.0012
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0012
268 Adenosine A2b receptor ADORA2B 0.0012
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0011
936 Ephrin type-A receptor 2 EPHA2 0.0011
1268 Neuropeptide S receptor NPSR1 0.0011
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0011
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0011
754 Pancreatic triacylglycerol lipase PNLIP 0.0011
2540 Choloylglycine hydrolase cbh 0.0011
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0011
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0011
724 Interleukin-2 receptor alpha chain IL2RA 0.0011
717 Interleukin-2 receptor subunit beta IL2RB 0.0011
164 Histamine H4 receptor HRH4 0.001
54 Prothrombin F2 0.001
5798 Mitogen-activated protein kinase 11 MAPK11 0.001
1810 Protein S100-A1 S100A1 0.001
6097 Protein S100-A2 S100A2 0.001
4228 Keratin, type II cytoskeletal 7 KRT7 0.001
2461 D-alanyl-D-alanine carboxypeptidase Not Available 0.001
5756 D-alanyl-D-alanine carboxypeptidase dac 0.001
6073 Potassium channel subfamily K member 9 KCNK9 0.001
6072 Potassium channel subfamily K member 3 KCNK3 0.001
517 Alcohol dehydrogenase 1C ADH1C 0.001
569 Retinal dehydrogenase 2 ALDH1A2 0.001
1144 Hepatocyte growth factor receptor MET 0.001
493 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial CYP27B1 0.001
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.001
512 DNA-directed RNA polymerase alpha chain rpoA 0.001
5772 DNA-directed RNA polymerase alpha chain rpoA 0.001
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.001
4041 Microsomal glutathione S-transferase 2 MGST2 0.001
7 Nitric oxide synthase, inducible NOS2 0.001
6837 Serine/threonine-protein kinase 17B STK17B 0.001
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.001
1275 Estrogen sulfotransferase SULT1E1 0.001
611 Retinal dehydrogenase 1 ALDH1A1 0.001
2268 Cholesterol oxidase choB 0.0009
2822 Cholesterol oxidase choA 0.0009
4773 Deoxycytidine kinase DCK 0.0009
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0009
6105 3-oxo-5-beta-steroid 4-dehydrogenase AKR1D1 0.0009
1048 Protein S100-A13 S100A13 0.0009
2226 Protein S100-A12 S100A12 0.0009
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0009
1770 Phospholipase C PLCL1 0.0009
2841 Phospholipase C plc 0.0009
2298 Cytochrome P450-cam camC 0.0009
1039 Histone deacetylase 9 HDAC9 0.0009
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0009
908 Glutathione S-transferase theta-1 GSTT1 0.0009
6131 Carbonic anhydrase 14 CA14 0.0009
2283 Steroid Delta-isomerase ksi 0.0009
2920 Steroid Delta-isomerase ksi 0.0009
153 Dopamine beta-hydroxylase DBH 0.0009
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0009
390 Adenosine A3 receptor ADORA3 0.0009
2132 Protein S100-B S100B 0.0009
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0008
3404 Exotoxin A eta 0.0008
6500 Phospholipase A2 PLA2G1B 0.0008
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.0008
22 30S ribosomal protein S4 rpsD 0.0008
6714 30S ribosomal protein S4 rpsD 0.0008
6122 Carbonic anhydrase 3 CA3 0.0008
2325 Sulfotransferase family cytosolic 2B member 1 SULT2B1 0.0008
2232 Interleukin-5 IL5 0.0008
1593 Mucin-2 MUC2 0.0008
4031 Glutathione S-transferase A1 GSTA1 0.0008
6599 HTH-type transcriptional regulator ttgR ttgR 0.0008
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0008
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0008
1649 Small inducible cytokine A2 CCL2 0.0008
3957 Adenosine deaminase ADA 0.0008
1025 Aquaporin-1 AQP1 0.0008
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0008
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0008
2091 Endoplasmin HSP90B1 0.0008
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.0007
896 Glutathione S-transferase Mu 1 GSTM1 0.0007
473 L-lactate dehydrogenase A chain LDHA 0.0007
461 Glycine receptor subunit alpha-3 GLRA3 0.0007
130 Prostacyclin synthase PTGIS 0.0007
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0007
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.0007
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.0007
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.0007
2290 ADP-ribosyl cyclase 2 BST1 0.0007
226 Gonadotropin-releasing hormone receptor GNRHR 0.0007
1830 5'-nucleotidase NT5E 0.0007
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0007
125 DNA polymerase beta POLB 0.0007
131 Synaptic vesicular amine transporter SLC18A2 0.0007
1123 Eosinophil cationic protein RNASE3 0.0007
144 Hemoglobin subunit alpha HBA1 0.0006
106 Cannabinoid receptor 2 CNR2 0.0006
4943 Cytochrome c6 petJ 0.0006
4954 Soluble cytochrome b558 Not Available 0.0006
4916 Cyanoglobin glbN 0.0006
4947 Bacterial hemoglobin vhb 0.0006
4936 Cytochrome c2 iso-2 Not Available 0.0006
4994 Hemoglobin-like protein HbO glbO 0.0006
5000 HemO hemO 0.0006
4942 Diheme cytochrome c napB napB 0.0006
4975 Cytochrome c-556 RPA3973 0.0006
4915 Cytochrome c-550 psbV 0.0006
4959 Cytochrome c-550 psbV 0.0006
5216 Cytochrome c-550 psbV 0.0006
4925 Cytochrome c-type protein SHP shp 0.0006
4934 Cytochrome c-551 nirM 0.0006
5218 Cytochrome c-551 nirM 0.0006
4905 Cytochrome c2 Not Available 0.0006
4939 Cytochrome c2 cycA 0.0006
4964 Cytochrome c2 cycA 0.0006
4979 Cytochrome c2 cycA 0.0006
6673 Cytochrome c2 cycA 0.0006
4981 Iron-starvation protein PigA pigA 0.0006
4984 Neuroglobin NGB 0.0006
4961 Hemophore HasA hasA 0.0006
4935 Cytochrome c-554 cycA1 0.0006
4909 CooA protein cooA 0.0006
3116 Bacterioferritin bfr 0.0006
4906 Bacterioferritin bfr 0.0006
4965 Bacterioferritin bfr 0.0006
4910 Cytoglobin CYGB 0.0006
4998 Hemoglobin-like protein yjbI yjbI 0.0006
4904 Cytochrome c family protein GSU1996 0.0006
644 Heme oxygenase 2 HMOX2 0.0006
4982 Heme oxygenase 2 pbsA2 0.0006
4937 Cytochrome oxidase subunit II rcoxA 0.0006
4931 Cytochrome P450 167A1 CYP167A1 0.0006
4971 Nonaheme cytochrome c hmcA 0.0006
4989 Cytochrome c551 peroxidase ccp 0.0006
5222 Cytochrome c551 peroxidase ccpA 0.0006
4976 Apocytochrome f petA 0.0006
6407 Apocytochrome f petA 0.0006
4907 Cytochrome c-L moxG 0.0006
6865 Cytochrome c-L moxG 0.0006
4999 Cytochrome P450 165B3 CYP165B3 0.0006
4960 Putative cytochrome P450-family protein SCO7417 0.0006
4903 Methyl-accepting chemotaxis protein Tar4 0.0006
4764 Cytochrome P450 165C4 CYP165C4 0.0006
4926 Heme-based aerotactic transducer hemAT hemAT 0.0006
4972 P450cin cinA 0.0006
4922 Cytochrome c, putative SO_4144 0.0006
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0006
4993 Hydroxylamine oxidoreductase hao1 0.0006
4952 Catalase/peroxidase katA 0.0006
3093 Catalase HPII katE 0.0006
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0006
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.0006
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0006
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.0006
3611 Cytidine deaminase cdd 0.0006
3707 Cytidine deaminase cdd 0.0006
4211 Cytidine deaminase CDA 0.0006
1569 G1/S-specific cyclin-D1 CCND1 0.0006
1341 Histamine H3 receptor HRH3 0.0005
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0005
6743 Non-fluorescent flavoprotein luxF 0.0005
6753 Apolipoprotein M APOM 0.0005
2528 Fatty acid metabolism regulator protein fadR 0.0005
6740 Fatty acid metabolism regulator protein fadR 0.0005
6752 Guanylyl cyclase-activating protein 1 GUCA1A 0.0005
394 Calcineurin subunit B isoform 1 PPP3R1 0.0005
6742 Recoverin RCVRN 0.0005
6747 Chalcone/stilbene synthase family protein MT1417 0.0005
6741 Peroxisomal 3,2-trans-enoyl-CoA isomerase PECI 0.0005
6522 Hepatocyte nuclear factor 4-alpha HNF4A 0.0005
6751 Gag polyprotein gag 0.0005
6746 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform PPP3CA 0.0005
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0005
6749 Polyprotein Not Available 0.0005
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0005
6211 Tubulin epsilon chain TUBE1 0.0005
6212 Tubulin gamma-1 chain TUBG1 0.0005
6210 Tubulin delta chain TUBD1 0.0005
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0005
291 Nitric-oxide synthase, endothelial NOS3 0.0005
4920 Peroxidase/catalase katG 0.0005
5961 Insulin INS 0.0005
4948 Cytochrome c-553 Not Available 0.0005
2119 Cytochrome b5 CYB5A 0.0005
4923 Cytochrome c3 DvMF_2499 0.0005
4945 Cytochrome c3 Not Available 0.0005
4949 Cytochrome c3 DVU_3171 0.0005
4968 Cytochrome c3 cytc3 0.0005
4997 Cytochrome c3 SO_2727 0.0005
5219 Cytochrome c3 cyd 0.0005
4902 Nine-heme cytochrome c Ddes_2038 0.0005
3189 High-molecular-weight cytochrome c hmcA 0.0005
4990 PpcA ppcA 0.0005
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0005
3375 Acidic cytochrome c3 Not Available 0.0005
4988 Sulfite oxidase, mitochondrial SUOX 0.0005
3570 Cytochrome P450 152A1 cypC 0.0005
4037 Hypothetical protein GPX1 0.0005
4297 Hypothetical protein SP_1951 0.0005
4521 Hypothetical protein BC_2969 0.0005
4540 Hypothetical protein TM_1070 0.0005
4555 Hypothetical protein MT1739 0.0005
4569 Hypothetical protein mshD 0.0005
4578 Hypothetical protein PA3270 0.0005
4747 Hypothetical protein PA3967 0.0005
5177 Hypothetical protein TM_0096 0.0005
5194 Hypothetical protein PA1204 0.0005
5240 Hypothetical protein Rv2991 0.0005
5370 Hypothetical protein TM_1158 0.0005
5710 Hypothetical protein Tb927.5.1360 0.0005
2915 Sensor protein fixL fixL 0.0005
4944 Sensor protein fixL fixL 0.0005
4813 Heme oxygenase hmuO 0.0005
5769 Heme oxygenase Not Available 0.0005
4289 Cytochrome P450 TT_P0059 0.0005
6262 Cytochrome P450 staP 0.0005
4385 Cytochrome c' Not Available 0.0005
4967 Cytochrome c' cycA 0.0005
5038 Cytochrome c' Not Available 0.0005
5223 Cytochrome c' cycP 0.0005
4992 Cytochrome c peroxidase Not Available 0.0005
2236 Casein kinase II subunit alpha CSNK2A1 0.0005
6527 Lymphocyte antigen 96 LY96 0.0005
6755 Poliovirus receptor PVR 0.0005
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0004
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0004
2230 Catalase CAT 0.0004
3249 Catalase katA 0.0004
3625 Catalase katA 0.0004
4539 Catalase katA 0.0004
4941 Catalase katB 0.0004
6750 ADP-ribosylation factor 6 ARF6 0.0004
4373 Medium-chain-fatty-acid--CoA ligase Not Available 0.0004
6524 Protein tonB tonB 0.0004
3670 Soluble cytochrome b562 precursor cybC 0.0004
3411 Cytochrome P450 121 cyp121 0.0004
3291 Cytochrome c-552 cycA 0.0004
4927 Cytochrome c-552 nrfA 0.0004
4938 Cytochrome c-552 cycA 0.0004
4953 Cytochrome c-552 nrfA 0.0004
5217 Cytochrome c-552 cycM 0.0004
2617 Nitric oxide synthase oxygenase nos 0.0004
2701 Nitric oxide synthase oxygenase nos 0.0004
1374 Natriuretic peptides B NPPB 0.0004
1827 Gap junction alpha-1 protein GJA1 0.0004
1908 Vascular cell adhesion protein 1 VCAM1 0.0004
3102 Flavohemoprotein hmp 0.0004
4969 Flavohemoprotein hmp 0.0004
4386 Hemoglobin-like protein HbN glbN 0.0004
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0004
1063 Signal transducer and activator of transcription 5B STAT5B 0.0004
2616 Ganglioside GM2 activator GM2A 0.0004
76 Nitric-oxide synthase, brain NOS1 0.0004
2435 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase lpxC 0.0004
6613 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase lpxC 0.0004
1176 Mitogen-activated protein kinase 1 MAPK1 0.0004
251 Alcohol dehydrogenase 1A ADH1A 0.0004
3127 Nitrite reductase nirS 0.0004
3284 Nitrite reductase nirS 0.0004
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0004
3221 Cytochrome c4 cc4 0.0004
2972 6-deoxyerythronolide B hydroxylase eryF 0.0004
2297 Genome polyprotein Not Available 0.0004
2322 Genome polyprotein Not Available 0.0004
2694 Genome polyprotein Not Available 0.0004
2719 Genome polyprotein Not Available 0.0004
2860 Genome polyprotein Not Available 0.0004
2928 Genome polyprotein Not Available 0.0004
3160 Genome polyprotein Not Available 0.0004
3260 Genome polyprotein Not Available 0.0004
4783 Genome polyprotein Not Available 0.0004
5726 Genome polyprotein Not Available 0.0004
5779 Genome polyprotein Not Available 0.0004
5867 Genome polyprotein Not Available 0.0004
6253 Genome polyprotein Not Available 0.0004
6301 Genome polyprotein Not Available 0.0004
6380 Genome polyprotein Not Available 0.0004
6381 Genome polyprotein Not Available 0.0004
6437 Genome polyprotein Not Available 0.0004
6520 Genome polyprotein Not Available 0.0004
6521 Genome polyprotein Not Available 0.0004
6652 Genome polyprotein Not Available 0.0004
6734 Genome polyprotein Not Available 0.0004
6735 Genome polyprotein Not Available 0.0004
6736 Genome polyprotein Not Available 0.0004
6737 Genome polyprotein Not Available 0.0004
6738 Genome polyprotein Not Available 0.0004
6739 Genome polyprotein Not Available 0.0004
6744 Genome polyprotein Not Available 0.0004
6748 Genome polyprotein Not Available 0.0004
6894 Genome polyprotein Not Available 0.0004
6898 Genome polyprotein Not Available 0.0004
6316 ADP-ribosylation factor 1 ARF1 0.0004
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0004
820 Glycine receptor subunit alpha-2 GLRA2 0.0003
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0003
4608 Putative cytochrome P450 SCO1207 0.0003
4963 Putative cytochrome P450 SCO2884 0.0003
6254 Putative cytochrome P450 SCO6998 0.0003
864 Gag-Pol polyprotein gag-pol 0.0003
2237 Gag-Pol polyprotein gag-pol 0.0003
2326 Gag-Pol polyprotein gag-pol 0.0003
2451 Gag-Pol polyprotein gag-pol 0.0003
2901 Gag-Pol polyprotein gag-pol 0.0003
3165 Gag-Pol polyprotein gag-pol 0.0003
3722 Gag-Pol polyprotein gag-pol 0.0003
6306 Gag-Pol polyprotein gag-pol 0.0003
6624 Gag-Pol polyprotein gag-pol 0.0003
828 Phenylalanine-4-hydroxylase PAH 0.0003
3109 Phenylalanine-4-hydroxylase phhA 0.0003
444 Alcohol dehydrogenase 1B ADH1B 0.0003
2240 Cell division protein kinase 2 CDK2 0.0003
358 Cystathionine beta-synthase CBS 0.0003
1507 Cytochrome c CYCS 0.0003
693 Hemoglobin subunit beta HBB 0.0003
2427 Ferrichrome-iron receptor fhuA 0.0003
6268 Hydroxyacid oxidase 1 HAO1 0.0003
810 Heme oxygenase 1 HMOX1 0.0003
3391 Heme oxygenase 1 pbsA1 0.0003
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0003
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0003
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0003
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0003
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0003
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0003
6264 cAMP-dependent protein kinase inhibitor alpha PKIA 0.0003
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0003
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.0003
1360 Sphingomyelin phosphodiesterase SMPD1 0.0003
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0002
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0002
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0002
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0002
6135 Sodium channel subunit beta-4 SCN4B 0.0002
6134 Sodium channel subunit beta-3 SCN3B 0.0002
6132 Sodium channel subunit beta-1 SCN1B 0.0002
6127 Carbonic anhydrase-related protein CA8 0.0002
6128 Carbonic anhydrase-related protein 10 CA10 0.0002
6133 Sodium channel subunit beta-2 SCN2B 0.0002
6129 Carbonic anhydrase-related protein 11 CA11 0.0002
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0002
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0002
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0002
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0002
6130 Carbonic anhydrase 13 CA13 0.0002
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0002
3007 Carbonic anhydrase 12 CA12 0.0002
4205 Carbonic anhydrase 9 CA9 0.0002
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0002
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