DT-Web

DB01394 - Colchicine


Identification
Name Colchicine
Accession Number DB01394
Type small molecule
Description A major alkaloid from Colchicum autumnale L. and found also in other Colchicum species. Its primary therapeutic use is in the treatment of gout, but it has been used also in the therapy of familial Mediterranean fever (periodic disease). [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 399.437
Groups approved
Monoisotopic Weight 399.168187537
Pharmacology
Indication For treatment and relief of pain in attacks of acute gouty arthritis.
Mechanism of action The precise mechanism of action has not been completely established. In patients with gout, colchicine apparently interrupts the cycle of monosodium urate crystal deposition in joint tissues and the resultant inflammatory response that initiates and sustains an acute attack. Colchicine decreases leukocyte chemotaxis and phagocytosis and inhibits the formation and release of a chemotactic glycoprotein that is produced during phagocytosis of urate crystals. Colchicine also inhibits urate crystal deposition, which is enhanced by a low pH in the tissues, probably by inhibiting oxidation of glucose and subsequent lactic acid production in leukocytes. Colchicine has no analgesic or antihyperuricemic activity. Colchicine inhibits microtubule assembly in various cells, including leukocytes, probably by binding to and interfering with polymerization of the microtubule subunit tubulin. Although some studies have found that this action probably does not contribute significantly to colchicine's antigout action, a recent in vitro study has shown that it may be at least partially involved.
Absorption Colchicine is rapidly absorbed after oral administration, probably from the jejunum and ileum. However, the rate and extent of absorption are variable, depending on the tablet dissolution rate; variability in gastric emptying, intestinal motility, and pH at the absorption site; and the extent to which colchicine is bound to microtubules in gastrointestinal mucosal cells.
Protein binding Low to moderate (30 to 50%).
Biotransformation Probably hepatic. Although colchicine metabolites have not been identified in humans, metabolism by mammalian hepatic microsomes has been demonstrated in vitro.
Route of elimination In healthy volunteers (n=12) 40 - 65% of 1 mg orally administered colchicine was recovered unchanged in urine. Enterohepatic recirculation and biliary excretion are also postulated to play a role in colchicine elimination.
Toxicity The onset of toxic effects is usually delayed for several hours or more after the ingestion of an acute overdose. Nausea, vomiting, abdominal pain, and diarrhea occur first. The diarrhea may be bloody due to hemorrhagic gastroenteritis. Burning sensations of the throat, stomach, and skin may be prominent symptoms. Extensive vascular damage may result in shock. Kidney damage, evidenced by hematuria and oliguria, may occur. Muscular weakness may be marked, and ascending paralysis of the central nervous system may develop; the patient usually remains conscious. Delirium and convulsions may occur. Death due to respiratory arrest may result. Although death from the ingestion of as little as 7 mg has been reported, much larger doses have been survived .
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Atorvastatin Increased risk of rhadbomyolysis with this combination.
Bicalutamide CYP3A4 Inhibitors like bicalutamide may increase the serum concentration of colchicine. Increase monitoring for colchicine-related toxicity when using such combinations. Use extra caution in patients with impaired renal and/or hepatic function.
Cerivastatin Increased risk of rhabdomyolysis with this combination
Clarithromycin Severe colchicine toxicity can occur
Clotrimazole CYP3A4 Inhibitors (Moderate) such as clotrimazole may increase the serum concentration of colchicine. Reduce colchicine dose (for gout flares: to 1.2 mg x 1 dose, with next dose no sooner than 3 days later; for Familial Mediterranean Fever: to no more than 1.2 mg/day) when using in combination with a moderate CYP3A4 inhibitor such as erythromycin or verapamil. Increase monitoring for colchicine-related toxicity when using such combinations. Use extra caution in patients with impaired renal and/or hepatic function.
Conivaptan CYP3A4 Inhibitors (Strong) may increase the serum concentration of Colchicine. In patients with normal renal and hepatic function, reduce colchicine dose (for gout flares: to 0.6 mg x 1 dose, followed by 0.3 mg 1 hour later, with next dose no sooner than 3 days later; for gout flare prophylaxis: if target dose would otherwise be 0.6 mg daily, change to 0.3 mg every other day, and if target dose would otherwise be 0.6 mg twice daily, change to 0.3 mg daily; for Familial Mediterranean Fever: to no more than 0.6 mg/day) when using in combination with a strong CYP3A4 inhibitor such as clarithromycin or ritonavir. Increase monitoring for colchicine-related toxicity when using such combinations. Colchicine use is contraindicated in patients with impaired renal and/or hepatic function who are also receiving a strong CYP3A4 inhibitor.
Cyclosporine Increased toxicity of both drugs
Erythromycin Severe colchicine toxicity can occur
Fluvastatin Increased risk of rhabdomyolysis with this combination
Lovastatin Increased risk of rhabdomyolysis with this combination
Pitavastatin Increased incidence of adverse drug reactions (ie. rhabdomyolysis) of both colchicine and pitavastatin via pharmacodynamic synergism.
Pravastatin Increased risk of rhabdomyolysis with this combination
Rosuvastatin Increased risk of rhabdomyolysis with this combination
Simvastatin Increased risk of rhabdomyolysis with this combination
Telithromycin Telithromycin may reduce clearance of Colchicine. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Colchicine if Telithromycin is initiated, discontinued or dose changed.
Troleandomycin Severe colchicine toxicity can occur
Verapamil Verapamil may increase the serum concentration of Colchicine. This likely occurs via Verapamil-mediated inhibition of CYP3A4 and p-glycoprotein-mediated transport. Monitor for changes in the therapeutic/adverse effects of Colchicine if Verapamil is initiated, discontinued or dose changed.
Voriconazole Voriconazole, a strong CYP3A4 inhibitor, may increase the serum concentration of colchicine by decreasing its metabolism. A dose reduction of colchicine is recommended along with increased monitoring for colchicine toxicity. Concomitant therapy is contraindicated in patients with renal and/or hepatic impairment.
Food Interactions
  • Take without regard to meals.
  • Avoid alcohol since it increases uric acid levels.
  • Drink liberally.

Targets


Tubulin beta-1 chain
Name Tubulin beta-1 chain
Gene Name TUBB1
Pharmacological action yes
Actions inhibitor
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Acharya BR, Choudhury D, Das A, Chakrabarti G: Vitamin K3 disrupts the microtubule networks by binding to tubulin: a novel mechanism of its antiproliferative activity. Biochemistry. 2009 Jul 28;48(29):6963-74. - Pubmed
  • Li CM, Lu Y, Ahn S, Narayanan R, Miller DD, Dalton JT: Competitive mass spectrometry binding assay for characterization of three binding sites of tubulin. J Mass Spectrom. 2010 Sep 1. - Pubmed
  • Finkelstein Y, Aks SE, Hutson JR, Juurlink DN, Nguyen P, Dubnov-Raz G, Pollak U, Koren G, Bentur Y: Colchicine poisoning: the dark side of an ancient drug. Clin Toxicol (Phila). 2010 Jun;48(5):407-14. - Pubmed
  • Cerquaglia C, Diaco M, Nucera G, La Regina M, Montalto M, Manna R: Pharmacological and clinical basis of treatment of Familial Mediterranean Fever (FMF) with colchicine or analogues: an update. Curr Drug Targets Inflamm Allergy. 2005 Feb;4(1):117-24. - Pubmed
DTHybrid score 0.3383
Tubulin beta chain
Name Tubulin beta chain
Gene Name TUBB
Pharmacological action yes
Actions inhibitor
References
  • Yee KW, Hagey A, Verstovsek S, Cortes J, Garcia-Manero G, O'Brien SM, Faderl S, Thomas D, Wierda W, Kornblau S, Ferrajoli A, Albitar M, McKeegan E, Grimm DR, Mueller T, Holley-Shanks RR, Sahelijo L, Gordon GB, Kantarjian HM, Giles FJ: Phase 1 study of ABT-751, a novel microtubule inhibitor, in patients with refractory hematologic malignancies. Clin Cancer Res. 2005 Sep 15;11(18):6615-24. - Pubmed
  • Acharya BR, Choudhury D, Das A, Chakrabarti G: Vitamin K3 disrupts the microtubule networks by binding to tubulin: a novel mechanism of its antiproliferative activity. Biochemistry. 2009 Jul 28;48(29):6963-74. - Pubmed
  • Li CM, Lu Y, Ahn S, Narayanan R, Miller DD, Dalton JT: Competitive mass spectrometry binding assay for characterization of three binding sites of tubulin. J Mass Spectrom. 2010 Sep 1. - Pubmed
  • Cerquaglia C, Diaco M, Nucera G, La Regina M, Montalto M, Manna R: Pharmacological and clinical basis of treatment of Familial Mediterranean Fever (FMF) with colchicine or analogues: an update. Curr Drug Targets Inflamm Allergy. 2005 Feb;4(1):117-24. - Pubmed
DTHybrid score 0.3083

Enzymes


Cytochrome P450 3A4
Name Cytochrome P450 3A4
Gene Name CYP3A4
Actions substrate,inhibitor,inducer
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.7693
Cytochrome P450 2B6
Name Cytochrome P450 2B6
Gene Name CYP2B6
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.3587
Cytochrome P450 2C8
Name Cytochrome P450 2C8
Gene Name CYP2C8
Actions inhibitor,inducer
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.4008
Cytochrome P450 2C9
Name Cytochrome P450 2C9
Gene Name CYP2C9
Actions inhibitor,inducer
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.4963
Cytochrome P450 2E1
Name Cytochrome P450 2E1
Gene Name CYP2E1
Actions inducer
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.3301

Transporters


Multidrug resistance protein 3
Name Multidrug resistance protein 3
Gene Name ABCB4
Actions inducer
References
  • Vollrath V, Wielandt AM, Acuna C, Duarte I, Andrade L, Chianale J: Effect of colchicine and heat shock on multidrug resistance gene and P-glycoprotein expression in rat liver. J Hepatol. 1994 Nov;21(5):754-63. - Pubmed
DTHybrid score 0.2594
Solute carrier family 22 member 3
Name Solute carrier family 22 member 3
Gene Name SLC22A3
Actions inhibitor
References
  • Grundemann D, Schechinger B, Rappold GA, Schomig E: Molecular identification of the corticosterone-sensitive extraneuronal catecholamine transporter. Nat Neurosci. 1998 Sep;1(5):349-51. - Pubmed
DTHybrid score 0.2143
Multidrug resistance protein 1
Name Multidrug resistance protein 1
Gene Name ABCB1
Actions substrate,inhibitor
References
  • Polli JW, Wring SA, Humphreys JE, Huang L, Morgan JB, Webster LO, Serabjit-Singh CS: Rational use of in vitro P-glycoprotein assays in drug discovery. J Pharmacol Exp Ther. 2001 Nov;299(2):620-8. - Pubmed
  • Schwab D, Fischer H, Tabatabaei A, Poli S, Huwyler J: Comparison of in vitro P-glycoprotein screening assays: recommendations for their use in drug discovery. J Med Chem. 2003 Apr 24;46(9):1716-25. - Pubmed
  • Nagy H, Goda K, Fenyvesi F, Bacso Z, Szilasi M, Kappelmayer J, Lustyik G, Cianfriglia M, Szabo G Jr: Distinct groups of multidrug resistance modulating agents are distinguished by competition of P-glycoprotein-specific antibodies. Biochem Biophys Res Commun. 2004 Mar 19;315(4):942-9. - Pubmed
  • Troutman MD, Thakker DR: Novel experimental parameters to quantify the modulation of absorptive and secretory transport of compounds by P-glycoprotein in cell culture models of intestinal epithelium. Pharm Res. 2003 Aug;20(8):1210-24. - Pubmed
  • Ambudkar SV, Lelong IH, Zhang J, Cardarelli CO, Gottesman MM, Pastan I: Partial purification and reconstitution of the human multidrug-resistance pump: characterization of the drug-stimulatable ATP hydrolysis. Proc Natl Acad Sci U S A. 1992 Sep 15;89(18):8472-6. - Pubmed
  • Bebawy M, Morris MB, Roufogalis BD: A continuous fluorescence assay for the study of P-glycoprotein-mediated drug efflux using inside-out membrane vesicles. Anal Biochem. 1999 Mar 15;268(2):270-7. - Pubmed
  • Kuo CC, Hsieh HP, Pan WY, Chen CP, Liou JP, Lee SJ, Chang YL, Chen LT, Chen CT, Chang JY: BPR0L075, a novel synthetic indole compound with antimitotic activity in human cancer cells, exerts effective antitumoral activity in vivo. Cancer Res. 2004 Jul 1;64(13):4621-8. - Pubmed
  • Tiwari AK, Sodani K, Wang SR, Kuang YH, Ashby CR Jr, Chen X, Chen ZS: Nilotinib (AMN107, Tasigna) reverses multidrug resistance by inhibiting the activity of the ABCB1/Pgp and ABCG2/BCRP/MXR transporters. Biochem Pharmacol. 2009 Jul 15;78(2):153-61. Epub 2009 Apr 11. - Pubmed
DTHybrid score 0.542
Multidrug resistance-associated protein 1
Name Multidrug resistance-associated protein 1
Gene Name ABCC1
Actions substrate
References
  • Stride BD, Grant CE, Loe DW, Hipfner DR, Cole SP, Deeley RG: Pharmacological characterization of the murine and human orthologs of multidrug-resistance protein in transfected human embryonic kidney cells. Mol Pharmacol. 1997 Sep;52(3):344-53. - Pubmed
DTHybrid score 0.2785

Predictions


Id Partner name Gene Name Score
4119 Cytochrome P450 2D6 CYP2D6 0.3284
6016 Cytochrome P450 2C19 CYP2C19 0.3117
312 Tubulin beta chain TUB2 0.3083
4200 Cytochrome P450 1A2 CYP1A2 0.2556
4118 Cytochrome P450 3A5 CYP3A5 0.2398
6107 Cytochrome P450 3A7 CYP3A7 0.1719
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.1634
2539 Tubulin alpha-1 chain TUBA4A 0.1497
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.1298
5718 Cytochrome P450 2A6 CYP2A6 0.1209
6024 Cytochrome P450 1A1 CYP1A1 0.1202
587 Serum albumin ALB 0.1065
6144 Solute carrier family 22 member 2 SLC22A2 0.0925
2565 Tubulin beta-4 chain TUBB4 0.0911
6145 Solute carrier family 22 member 1 SLC22A1 0.0902
20 Prostaglandin G/H synthase 1 PTGS1 0.0899
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0893
2444 Tubulin beta-4q chain TUBB4Q 0.0874
2578 Tubulin beta-3 chain TUBB3 0.0862
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0859
556 Alpha-1A adrenergic receptor ADRA1A 0.0843
776 Bile salt export pump ABCB11 0.0822
2449 Tubulin alpha-3 chain TUBA1A 0.0806
2499 Tubulin beta-2C chain TUBB2C 0.0787
2480 Tubulin alpha-8 chain TUBA8 0.0785
2601 Tubulin alpha-2 chain TUBA3C 0.0785
2536 Tubulin alpha-6 chain TUBA1C 0.0745
2342 Tubulin alpha-ubiquitous chain TUBA1B 0.0745
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0737
789 Alpha-1D adrenergic receptor ADRA1D 0.0727
632 Alpha-1B adrenergic receptor ADRA1B 0.0694
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0669
1898 Cytochrome P450 1B1 CYP1B1 0.0662
118 Organic cation/carnitine transporter 2 SLC22A5 0.0645
817 DNA topoisomerase 2-alpha TOP2A 0.0638
1729 Solute carrier family 22 member 6 SLC22A6 0.0631
6106 Cytochrome P450 2C18 CYP2C18 0.0613
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0607
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0594
492 Histamine H1 receptor HRH1 0.058
3811 Cytochrome P450 19A1 CYP19A1 0.0576
6148 Multidrug resistance-associated protein 7 ABCC10 0.0556
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0553
824 Sodium-dependent serotonin transporter SLC6A4 0.0515
290 Prostaglandin G/H synthase 2 PTGS2 0.0513
6142 Solute carrier family 22 member 8 SLC22A8 0.0502
2164 Multidrug resistance-associated protein 4 ABCC4 0.0476
540 Sodium-dependent noradrenaline transporter SLC6A2 0.047
136 Estrogen receptor ESR1 0.0445
833 Organic cation/carnitine transporter 1 SLC22A4 0.0439
6143 Solute carrier family 22 member 7 SLC22A7 0.0413
731 HIV-1 protease HIV-1 protease 0.0409
6137 Multidrug resistance-associated protein 6 ABCC6 0.0407
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0383
502 5-hydroxytryptamine 2A receptor HTR2A 0.0369
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0368
220 Sodium channel protein type 5 subunit alpha SCN5A 0.036
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0353
871 Glucocorticoid receptor NR3C1 0.0348
831 D(2) dopamine receptor DRD2 0.0346
318 Alpha-2A adrenergic receptor ADRA2A 0.0344
5923 Microtubule-associated protein tau MAPT 0.0339
5924 Microtubule-associated protein 4 MAP4 0.0339
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0334
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0333
1852 Microtubule-associated protein 2 MAP2 0.0325
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0319
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0316
713 Sodium-dependent dopamine transporter SLC6A3 0.0316
260 Cytochrome P450 51 ERG11 0.0305
761 Cytochrome P450 51 ERG11 0.0305
3163 Cytochrome P450 51 cyp51 0.0305
273 Apoptosis regulator Bcl-2 BCL2 0.0303
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0293
3923 Cholinesterase BCHE 0.0289
465 Calmodulin CALM1 0.0286
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0283
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0282
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0281
3941 Amine oxidase [flavin-containing] A MAOA 0.0278
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0274
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0274
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0269
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0263
847 Mu-type opioid receptor OPRM1 0.0263
468 Cytochrome P450 4A11 CYP4A11 0.0261
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0256
378 Alpha-2C adrenergic receptor ADRA2C 0.0256
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0254
6136 Multidrug resistance-associated protein 5 ABCC5 0.0254
1024 Solute carrier family 22 member 11 SLC22A11 0.025
766 Beta-2 adrenergic receptor ADRB2 0.0249
6141 Sodium/bile acid cotransporter SLC10A1 0.0248
122 P2Y purinoceptor 12 P2RY12 0.0244
6211 Tubulin epsilon chain TUBE1 0.0244
6212 Tubulin gamma-1 chain TUBG1 0.0244
6210 Tubulin delta chain TUBD1 0.0244
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0239
467 Delta-type opioid receptor OPRD1 0.0227
4604 Liver carboxylesterase 1 CES1 0.0226
3939 Amine oxidase [flavin-containing] B MAOB 0.0225
6031 Cytochrome P450 3A43 CYP3A43 0.0222
23 D(1A) dopamine receptor DRD1 0.022
629 Alpha-2B adrenergic receptor ADRA2B 0.0218
696 Kappa-type opioid receptor OPRK1 0.0215
1629 Transcription factor AP-1 JUN 0.0215
590 5-hydroxytryptamine 2C receptor HTR2C 0.021
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0208
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0206
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0203
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0201
614 Progesterone receptor PGR 0.0198
341 5-hydroxytryptamine 3 receptor HTR3A 0.0198
891 Dihydropteroate synthase folP 0.0197
5359 Dihydropteroate synthase folP 0.0197
7175 Dihydropteroate synthase sulI 0.0197
193 Beta-1 adrenergic receptor ADRB1 0.0193
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0191
320 5-hydroxytryptamine 1A receptor HTR1A 0.0189
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0188
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0188
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0186
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0185
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0185
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0184
869 Estrogen receptor beta ESR2 0.0182
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.018
380 Cytochrome P450 17A1 CYP17A1 0.018
4120 NADPH--cytochrome P450 reductase POR 0.0175
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0173
146 Androgen receptor AR 0.0172
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0172
6182 Cytochrome P450 2J2 CYP2J2 0.0171
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0166
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0165
811 Translocator protein TSPO 0.0162
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0161
844 Epidermal growth factor receptor EGFR 0.016
952 Dipeptidyl peptidase 4 DPP4 0.0156
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0156
124 Histamine H2 receptor HRH2 0.0155
70 Type-1 angiotensin II receptor AGTR1 0.0155
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0154
482 Glycine receptor subunit alpha-1 GLRA1 0.0152
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0152
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0152
638 D(3) dopamine receptor DRD3 0.0152
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0151
6085 Fatty acid-binding protein, intestinal FABP2 0.015
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0149
756 Sex hormone-binding globulin SHBG 0.0145
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0142
504 Mast/stem cell growth factor receptor KIT 0.0139
131 Synaptic vesicular amine transporter SLC18A2 0.0137
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0135
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0135
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0135
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0135
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0135
6599 HTH-type transcriptional regulator ttgR ttgR 0.0134
5626 Nucleoside diphosphate kinase B NME2 0.0132
4116 Dihydropteroate synthetase Not Available 0.0131
6102 Arylamine N-acetyltransferase 2 NAT2 0.0131
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.013
885 5-hydroxytryptamine 1B receptor HTR1B 0.013
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.013
3307 Acriflavine resistance protein B acrB 0.013
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.013
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0129
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0129
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0128
3810 Catechol O-methyltransferase COMT 0.0128
6014 Cytochrome P450 2A13 CYP2A13 0.0128
281 5'-AMP-activated protein kinase subunit beta-1 PRKAB1 0.0127
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0127
705 Glutamate receptor 1 GRIA1 0.0126
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0125
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0125
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0125
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0125
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0125
738 Monocarboxylate transporter 1 SLC16A1 0.0125
6220 Aryl hydrocarbon receptor AHR 0.0125
777 Tumor necrosis factor TNF 0.0124
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0123
1010 Cytochrome P450 51A1 CYP51A1 0.0123
1757 Myeloperoxidase MPO 0.0122
1636 Trace amine-associated receptor 1 TAAR1 0.0122
1353 DNA topoisomerase 1 TOP1 0.0122
3552 DNA topoisomerase 1 topA 0.0122
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0122
537 ATP synthase delta chain, mitochondrial ATP5D 0.0121
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0121
442 Envelope glycoprotein gp41 0.012
4859 Envelope glycoprotein env 0.012
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0119
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0119
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0118
2331 HTH-type transcriptional regulator qacR qacR 0.0118
6461 HTH-type transcriptional regulator qacR qacR 0.0118
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0117
818 50S ribosomal protein L10 rplJ 0.0117
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0116
723 Cytosolic phospholipase A2 PLA2G4A 0.0116
737 Mineralocorticoid receptor NR3C2 0.0115
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0115
373 Transthyretin TTR 0.0115
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0114
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0114
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0114
365 Dihydrofolate reductase DHFR 0.0113
2381 Dihydrofolate reductase DFR1 0.0113
2833 Dihydrofolate reductase Not Available 0.0113
2931 Dihydrofolate reductase folA 0.0113
3544 Dihydrofolate reductase folA 0.0113
3682 Dihydrofolate reductase folA 0.0113
6642 Dihydrofolate reductase folA 0.0113
6756 Dihydrofolate reductase dfrA 0.0113
725 5-hydroxytryptamine 1D receptor HTR1D 0.0113
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0113
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0113
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0112
3947 Xanthine dehydrogenase/oxidase XDH 0.0112
477 DNA topoisomerase 4 subunit A parC 0.0111
886 DNA topoisomerase 4 subunit A parC 0.0111
6226 DNA topoisomerase 4 subunit A parC 0.0111
16 Adenosine A1 receptor ADORA1 0.0111
404 DNA gyrase subunit A gyrA 0.011
6224 DNA gyrase subunit A gyrA 0.011
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0109
1192 Sulfotransferase 1A1 SULT1A1 0.0106
5294 Nucleoside diphosphate kinase A NME1 0.0106
174 Sigma 1-type opioid receptor SIGMAR1 0.0106
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0105
407 Vascular endothelial growth factor receptor 2 KDR 0.0105
436 5-hydroxytryptamine 2B receptor HTR2B 0.0105
4203 Histamine N-methyltransferase HNMT 0.0104
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0102
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0102
982 Cocaine- and amphetamine-regulated transcript protein CARTPT 0.0101
904 Glutathione S-transferase P GSTP1 0.0101
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.01
474 Acetylcholinesterase ACHE 0.01
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0099
1050 Bile salt sulfotransferase SULT2A1 0.0098
1178 Adenosine A2a receptor ADORA2A 0.0097
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0097
4237 50S ribosomal protein L22 rplV 0.0097
94 5-hydroxytryptamine 4 receptor HTR4 0.0097
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0097
908 Glutathione S-transferase theta-1 GSTT1 0.0097
295 Carbonic anhydrase 1 CA1 0.0096
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0095
6058 Geranylgeranyl pyrophosphate synthetase GGPS1 0.0095
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0094
432 D(4) dopamine receptor DRD4 0.0093
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0093
853 Farnesyl pyrophosphate synthetase FDPS 0.0092
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0091
342 P protein [Includes: DNA-directed DNA polymerase P 0.0091
612 P protein [Includes: DNA-directed DNA polymerase P 0.0091
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0091
588 Chromodomain-helicase-DNA-binding protein 1 CHD1 0.0091
232 Corticosteroid-binding globulin SERPINA6 0.0091
26 Vascular endothelial growth factor receptor 3 FLT4 0.009
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.009
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.009
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.009
1656 CYP2B protein CYP2B 0.009
921 Glutamate receptor 2 GRIA2 0.0089
716 5-hydroxytryptamine 7 receptor HTR7 0.0089
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.0088
427 Substance-P receptor TACR1 0.0088
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0087
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0087
153 Dopamine beta-hydroxylase DBH 0.0087
32 Vascular endothelial growth factor receptor 1 FLT1 0.0087
592 Carbonic anhydrase 4 CA4 0.0086
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0086
3932 Glutathione S-transferase A2 GSTA2 0.0086
6020 Aldehyde oxidase AOX1 0.0085
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0085
228 Beta platelet-derived growth factor receptor PDGFRB 0.0085
4238 50S ribosomal protein L4 rplD 0.0085
5578 50S ribosomal protein L4 rplD 0.0085
6173 50S ribosomal protein L4 rplD 0.0085
6219 50S ribosomal protein L4 rplD 0.0085
24 Thymidylate synthase TMP1 0.0084
359 Thymidylate synthase TYMS 0.0084
2626 Thymidylate synthase thyA 0.0084
2729 Thymidylate synthase thyA 0.0084
5352 Thymidylate synthase THYA 0.0084
164 Histamine H4 receptor HRH4 0.0084
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0084
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0084
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0084
6432 Transporter snf 0.0083
183 Vascular endothelial growth factor A VEGFA 0.0083
4148 Serine/threonine-protein kinase mTOR MTOR 0.0083
6070 Nischarin NISCH 0.0083
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0083
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.0082
275 Arachidonate 5-lipoxygenase ALOX5 0.0082
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0082
6339 Ig kappa chain V-II region RPMI 6410 Not Available 0.0081
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0081
5787 Angiopoietin-1 receptor TEK 0.008
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0079
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0079
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0078
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0077
2183 Fatty acid-binding protein, adipocyte FABP4 0.0077
4773 Deoxycytidine kinase DCK 0.0076
2472 Voltage-gated potassium channel kcsA 0.0075
6366 Voltage-gated potassium channel kcsA 0.0075
4122 Histone deacetylase 2 HDAC2 0.0074
1541 Metalloproteinase mmp20 0.0074
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0074
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0074
613 Atrial natriuretic peptide receptor A NPR1 0.0074
6146 High affinity copper uptake protein 1 SLC31A1 0.0074
319 Opioid receptor, sigma 1 OPRS1 0.0073
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0073
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0073
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0073
88 Retinoic acid receptor RXR-beta RXRB 0.0072
1341 Histamine H3 receptor HRH3 0.0071
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0071
702 UMP-CMP kinase CMPK1 0.0071
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.007
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.007
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.007
3809 Estrogen-related receptor gamma ESRRG 0.0069
49 Endothelin B receptor EDNRB 0.0069
244 Angiotensin-converting enzyme ACE 0.0068
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0068
4192 DNA topoisomerase 2-beta TOP2B 0.0068
814 Ryanodine receptor 1 RYR1 0.0067
284 DNA-directed RNA polymerase beta chain rpoB 0.0067
5773 DNA-directed RNA polymerase beta chain rpoB 0.0067
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0066
444 Alcohol dehydrogenase 1B ADH1B 0.0066
578 Endothelin-1 receptor EDNRA 0.0065
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0065
461 Glycine receptor subunit alpha-3 GLRA3 0.0065
357 Carbonic anhydrase 2 CA2 0.0065
6149 Solute carrier family 22 member 10 SLC22A10 0.0064
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0064
3432 Multidrug-efflux transporter 1 regulator bmrR 0.0063
4476 Mannitol dehydrogenase mtlD 0.0063
133 Dihydropterate synthase sulI 0.0063
1064 DNA (cytosine-5)-methyltransferase 1 DNMT1 0.0063
251 Alcohol dehydrogenase 1A ADH1A 0.0062
6126 Carbonic anhydrase 7 CA7 0.0062
823 Fibroblast growth factor receptor 2 FGFR2 0.0062
163 D(1B) dopamine receptor DRD5 0.0062
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0061
5126 Arginase rocF 0.0061
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.006
2981 Phospholipase A2, membrane associated PLA2G2A 0.006
896 Glutathione S-transferase Mu 1 GSTM1 0.006
185 Vasopressin V1a receptor AVPR1A 0.006
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0059
856 Vitamin D3 receptor VDR 0.0059
1275 Estrogen sulfotransferase SULT1E1 0.0059
992 Protein tyrosine kinase 2 beta PTK2B 0.0059
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0059
322 Vasopressin V2 receptor AVPR2 0.0058
517 Alcohol dehydrogenase 1C ADH1C 0.0058
1618 High affinity nerve growth factor receptor NTRK1 0.0058
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0058
518 Peroxidase/catalase T katG 0.0057
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0057
6163 Copper-transporting ATPase 2 ATP7B 0.0057
6165 Copper-transporting ATPase 1 ATP7A 0.0057
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0057
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0057
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.0056
68 Cannabinoid receptor 1 CNR1 0.0055
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0055
780 Retinoic acid receptor RXR-gamma RXRG 0.0055
84 Nuclear receptor 0B1 NR0B1 0.0055
1517 Beta-3 adrenergic receptor ADRB3 0.0054
563 Thyroid peroxidase TPO 0.0054
7 Nitric oxide synthase, inducible NOS2 0.0053
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0053
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0053
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0053
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0053
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0053
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0052
469 Annexin A1 ANXA1 0.0052
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.0051
3823 Cytokine receptor common gamma chain IL2RG 0.0051
239 Coagulation factor X F10 0.0051
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0051
6043 Putative G-protein coupled receptor 44 GPR44 0.0051
54 Prothrombin F2 0.005
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.005
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.005
5300 Antigen peptide transporter 1 TAP1 0.005
1360 Sphingomyelin phosphodiesterase SMPD1 0.005
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.005
2599 Tyrosine-protein kinase HCK HCK 0.005
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0049
581 Cytochrome P450 2R1 CYP2R1 0.0048
2230 Catalase CAT 0.0048
3249 Catalase katA 0.0048
3625 Catalase katA 0.0048
4539 Catalase katA 0.0048
4941 Catalase katB 0.0048
1483 Membrane copper amine oxidase AOC3 0.0048
6766 O-GlcNAcase BT_4395 BT_4395 0.0048
489 Monocarboxylate transporter 2 SLC16A7 0.0048
165 FL cytokine receptor FLT3 0.0048
162 Retinoic acid receptor gamma-1 RARG 0.0047
624 Guanidinoacetate N-methyltransferase GAMT 0.0047
2616 Ganglioside GM2 activator GM2A 0.0047
683 Potassium transporter GK0582 0.0047
1648 Elastin ELN 0.0046
3937 Fatty-acid amide hydrolase FAAH 0.0045
527 Prostacyclin receptor PTGIR 0.0045
6167 Organic solute transporter subunit beta OSTB 0.0045
6166 Organic solute transporter subunit alpha OSTA 0.0045
2300 Lysozyme E 0.0045
3633 Lysozyme R 0.0045
5597 Lysozyme 17 0.0045
790 DNA polymerase subunit alpha B POLA2 0.0045
724 Interleukin-2 receptor alpha chain IL2RA 0.0045
717 Interleukin-2 receptor subunit beta IL2RB 0.0045
2178 Metabotropic glutamate receptor 5 GRM5 0.0045
208 DNA-directed RNA polymerase beta' chain rpoC 0.0044
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0044
4103 Proteasome subunit beta type 2 PSMB2 0.0044
4102 Proteasome subunit beta type 5 PSMB5 0.0044
4101 Proteasome subunit beta type 1 PSMB1 0.0044
1256 5-hydroxytryptamine 6 receptor HTR6 0.0044
1262 Corticotropin-lipotropin POMC 0.0044
130 Prostacyclin synthase PTGIS 0.0044
33 Cystine/glutamate transporter SLC7A11 0.0044
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0043
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0043
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0043
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.0042
6837 Serine/threonine-protein kinase 17B STK17B 0.0042
528 5-hydroxytryptamine 1E receptor HTR1E 0.0042
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0042
3917 Methylenetetrahydrofolate reductase MTHFR 0.0042
6174 50S ribosomal protein L32 rpmF 0.0042
768 FK506-binding protein 1A FKBP1A 0.0042
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0041
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0041
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0041
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0041
3997 Cytochrome P450 24A1, mitochondrial CYP24A1 0.0041
3808 Dihydropteroate synthase 2 folP2 0.0041
3601 Dihydropteroate synthase 1 folP1 0.0041
3807 Dihydropteroate synthase 1 folP1 0.0041
1630 Integrin beta-2 ITGB2 0.004
976 Platelet glycoprotein IX GP9 0.004
3868 Calcineurin subunit B isoform 2 PPP3R2 0.004
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.004
459 Retinoic acid receptor RXR-alpha RXRA 0.004
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0039
1129 C-C chemokine receptor type 5 CCR5 0.0039
2021 Thrombomodulin THBD 0.0039
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0038
571 Melatonin receptor type 1A MTNR1A 0.0038
362 Melatonin receptor type 1B MTNR1B 0.0038
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0038
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0038
3856 Fibroblast growth factor receptor 3 FGFR3 0.0038
828 Phenylalanine-4-hydroxylase PAH 0.0038
3109 Phenylalanine-4-hydroxylase phhA 0.0038
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0037
594 Thyroxine-binding globulin SERPINA7 0.0037
6103 Arylamine N-acetyltransferase 1 NAT1 0.0037
634 Squalene monooxygenase SQLE 0.0037
7196 Squalene monooxygenase ERG1 0.0037
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.0037
390 Adenosine A3 receptor ADORA3 0.0037
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0036
1992 Vitamin D-binding protein GC 0.0036
558 Solute carrier family 12 member 1 SLC12A1 0.0036
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0036
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0036
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0036
3404 Exotoxin A eta 0.0036
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0035
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0035
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0035
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0035
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0035
2112 Toll-like receptor 9 TLR9 0.0035
4311 tRNA TRDMT1 0.0035
4325 tRNA trmD 0.0035
4328 tRNA trmD 0.0035
751 Potassium channel subfamily K member 6 KCNK6 0.0035
6218 Pannexin-1 PANX1 0.0035
939 50S ribosomal protein L3 rplC 0.0035
758 Thyroid hormone receptor alpha THRA 0.0034
3929 Phosphoethanolamine/phosphocholine phosphatase PHOSPHO1 0.0034
3927 Choline transporter-like protein 3 SLC44A3 0.0034
549 Choline-phosphate cytidylyltransferase B PCYT1B 0.0034
769 High-affinity choline transporter 1 SLC5A7 0.0034
264 Choline/ethanolamine kinase [Includes: Choline kinase beta CHKB 0.0034
3933 Choline/ethanolaminephosphotransferase CEPT1 0.0034
1686 Choline transporter-like protein 1 SLC44A1 0.0034
3926 Choline transporter-like protein 2 SLC44A2 0.0034
861 Choline kinase alpha CHKA 0.0034
700 Choline dehydrogenase, mitochondrial CHDH 0.0034
291 Nitric-oxide synthase, endothelial NOS3 0.0034
3925 Choline transporter-like protein 4 SLC44A4 0.0034
576 Choline O-acetyltransferase CHAT 0.0034
3922 Phospholipase D2 PLD2 0.0034
3924 Phospholipase D1 PLD1 0.0034
596 3-oxo-5-alpha-steroid 4-dehydrogenase 1 SRD5A1 0.0033
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0033
5682 Ribonuclease pancreatic RNASE1 0.0033
3587 Gastrotropin FABP6 0.0033
6824 Tyrosine-protein kinase Lyn LYN 0.0033
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0033
293 Gamma-glutamyl hydrolase GGH 0.0033
5880 Thrombopoietin receptor MPL 0.0033
936 Ephrin type-A receptor 2 EPHA2 0.0032
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0032
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0032
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0032
172 Potassium channel subfamily K member 1 KCNK1 0.0032
229 Retinoic acid receptor beta RARB 0.0032
2107 Microtubule-associated protein 1A MAP1A 0.0032
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0032
3090 Chitosanase csn 0.0031
4149 Nuclear factor NF-kappa-B p100 subunit NFKB2 0.0031
140 30S ribosomal protein S9 rpsI 0.0031
6719 30S ribosomal protein S9 rpsI 0.0031
6725 30S ribosomal protein S9 rpsI 0.0031
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0031
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0031
1196 Complement decay-accelerating factor CD55 0.0031
730 Retinoic acid receptor alpha RARA 0.0031
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0031
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0031
65 Matrix metalloproteinase-9 Not Available 0.0031
820 Glycine receptor subunit alpha-2 GLRA2 0.0031
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0031
473 L-lactate dehydrogenase A chain LDHA 0.0031
3086 Plasmepsin-2 Not Available 0.0031
1227 Cytochrome b MT-CYB 0.0031
6386 Cytochrome b petB 0.0031
6937 Cytochrome b MT-CYB 0.0031
674 Dihydroorotate dehydrogenase homolog, mitochondrial PFF0160c 0.0031
5798 Mitogen-activated protein kinase 11 MAPK11 0.0031
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0031
346 Thyroid hormone receptor beta-1 THRB 0.0031
3913 Glutamic acid decarboxylase GAD65 0.003
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.003
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.003
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.003
6228 Nuclear receptor coactivator 1 NCOA1 0.003
2285 Streptogramin A acetyltransferase vatD 0.003
1374 Natriuretic peptides B NPPB 0.003
2207 Rhodopsin RHO 0.003
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.003
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.003
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.003
1827 Gap junction alpha-1 protein GJA1 0.003
1908 Vascular cell adhesion protein 1 VCAM1 0.003
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.003
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.003
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.003
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.003
2298 Cytochrome P450-cam camC 0.003
6241 Nuclear receptor coactivator 2 NCOA2 0.003
3611 Cytidine deaminase cdd 0.003
3707 Cytidine deaminase cdd 0.003
4211 Cytidine deaminase CDA 0.003
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0029
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0029
1650 Heme carrier protein 1 SLC46A1 0.0029
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0029
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0029
719 Retinoic acid receptor responder protein 1 RARRES1 0.0028
6459 Glycodelin PAEP 0.0028
770 Retinoic acid-induced protein 3 GPRC5A 0.0028
2290 ADP-ribosyl cyclase 2 BST1 0.0028
605 Fumarate reductase flavoprotein subunit frdA 0.0028
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0028
3673 Fumarate reductase flavoprotein subunit fccA 0.0028
4912 Fumarate reductase flavoprotein subunit ifcA 0.0028
6549 Fumarate reductase flavoprotein subunit frdA 0.0028
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0028
1291 cAMP response element-binding protein CREB1 0.0028
1435 Synaptic vesicle glycoprotein 2A SV2A 0.0028
268 Adenosine A2b receptor ADORA2B 0.0028
3957 Adenosine deaminase ADA 0.0028
1253 Interferon gamma IFNG 0.0028
330 Spermidine synthase SRM 0.0028
3038 Spermidine synthase speE 0.0028
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0028
1200 AMBP protein AMBP 0.0028
3866 Serum amyloid A protein SAA1 0.0028
1932 Apolipoprotein E APOE 0.0028
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0027
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0027
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0027
2808 Chloramphenicol acetyltransferase 3 cat3 0.0027
6232 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short GNAS 0.0027
6233 Adenylate cyclase type 2 ADCY2 0.0027
6234 Adenylate cyclase type 5 ADCY5 0.0027
199 Monocarboxylate transporter 8 SLC16A2 0.0027
106 Cannabinoid receptor 2 CNR2 0.0027
6168 Solute carrier family 22 member 16 SLC22A16 0.0027
1144 Hepatocyte growth factor receptor MET 0.0027
4210 Toll-like receptor 4 TLR4 0.0027
4173 Tyrosine-protein kinase JAK2 JAK2 0.0027
2159 Quinone oxidoreductase CRYZ 0.0027
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.0027
358 Cystathionine beta-synthase CBS 0.0027
5934 Cytochrome P450 26A1 CYP26A1 0.0027
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0027
1792 Tissue-type plasminogen activator PLAT 0.0027
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0026
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0026
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0026
4217 Telomerase reverse transcriptase TERT 0.0026
5997 Tumor necrosis factor ligand superfamily member 11 TNFSF11 0.0026
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0026
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0026
1268 Neuropeptide S receptor NPSR1 0.0026
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0026
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0026
511 5-hydroxytryptamine 1F receptor HTR1F 0.0026
3639 Thymidine phosphorylase deoA 0.0025
3936 Thymidine phosphorylase TYMP 0.0025
735 Alanine aminotransferase 1 GPT 0.0025
3904 Alanine aminotransferase 2 GPT2 0.0025
1385 Angiotensin-converting enzyme 2 ACE2 0.0025
6033 High affinity interleukin-8 receptor A CXCR1 0.0025
569 Retinal dehydrogenase 2 ALDH1A2 0.0025
267 Plasminogen activator inhibitor 1 SERPINE1 0.0025
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0025
2417 Chloramphenicol acetyltransferase cat 0.0025
3278 Chloramphenicol acetyltransferase cat 0.0025
2810 Dr hemagglutinin structural subunit draA 0.0025
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0025
1313 Lactoylglutathione lyase GLO1 0.0025
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0025
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0024
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0024
334 S-adenosylmethionine synthetase isoform type-2 MAT2A 0.0024
544 Potassium voltage-gated channel subfamily E member 1 KCNE1 0.0024
6039 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A PDE11A 0.0024
233 Potassium channel subfamily K member 2 KCNK2 0.0024
5852 Type-2 angiotensin II receptor AGTR2 0.0024
6048 Troponin C, skeletal muscle TNNC2 0.0024
611 Retinal dehydrogenase 1 ALDH1A1 0.0024
1770 Phospholipase C PLCL1 0.0024
2841 Phospholipase C plc 0.0024
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0024
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0024
642 3-oxo-5-alpha-steroid 4-dehydrogenase 2 SRD5A2 0.0023
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0023
4221 Vascular endothelial growth factor VEGF 0.0023
6073 Potassium channel subfamily K member 9 KCNK9 0.0023
6072 Potassium channel subfamily K member 3 KCNK3 0.0023
5816 Cadherin-5 CDH5 0.0023
453 S-adenosylmethionine synthetase isoform type-1 MAT1A 0.0023
6042 Prostaglandin reductase 2 PTGR2 0.0023
6221 Steroid hormone receptor ERR1 ESRRA 0.0023
3221 Cytochrome c4 cc4 0.0023
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0022
6044 Serum paraoxonase/lactonase 3 PON3 0.0022
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0022
113 S-adenosylmethionine decarboxylase proenzyme AMD1 0.0022
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0022
1039 Histone deacetylase 9 HDAC9 0.0022
686 Aldo-keto reductase family 1 member C2 AKR1C2 0.0022
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.0022
411 Glycine N-methyltransferase GNMT 0.0022
2232 Interleukin-5 IL5 0.0022
298 Renin REN 0.0021
1593 Mucin-2 MUC2 0.0021
6506 Stathmin-4 STMN4 0.0021
76 Nitric-oxide synthase, brain NOS1 0.0021
572 Integrin alpha-L ITGAL 0.0021
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0021
2320 Thymidine kinase, cytosolic TK1 0.002
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.002
5433 UPF0230 protein TM_1468 TM_1468 0.002
3616 Fatty acid-binding protein, epidermal FABP5 0.002
5431 Lipid binding protein Not Available 0.002
5430 Hepatocyte nuclear factor 4-gamma HNF4G 0.002
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.002
2216 Fibroblast growth factor receptor 4 FGFR4 0.002
633 Penicillin-binding proteins 1A/1B pbpA 0.0019
718 Folate receptor gamma FOLR3 0.0019
299 Folate receptor beta FOLR2 0.0019
804 Mitochondrial folate transporter/carrier SLC25A32 0.0019
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0019
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0019
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0019
6131 Carbonic anhydrase 14 CA14 0.0019
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0019
5818 Folate receptor alpha FOLR1 0.0019
4041 Microsomal glutathione S-transferase 2 MGST2 0.0018
5998 Toll-like receptor 8 TLR8 0.0018
712 Tubulin alpha chain TUB1 0.0018
1968 ATP-sensitive inward rectifier potassium channel 12 KCNJ12 0.0018
565 Extracellular calcium-sensing receptor CASR 0.0018
2391 Ferrochelatase hemH 0.0018
6502 Ferrochelatase DKFZp686P18130 0.0018
1591 Ferrochelatase, mitochondrial FECH 0.0018
6122 Carbonic anhydrase 3 CA3 0.0018
1123 Eosinophil cationic protein RNASE3 0.0018
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.0017
543 Penicillin-binding protein 1B mrcB 0.0017
6186 Penicillin-binding protein 1B ponB 0.0017
6822 Penicillin-binding protein 1b pbp1b 0.0017
6844 Penicillin-binding protein 1b pbp1b 0.0017
283 SEC14-like protein 2 SEC14L2 0.0017
159 Penicillin-binding protein 2B penA 0.0017
6121 Penicillin-binding protein 2B penA 0.0017
144 Hemoglobin subunit alpha HBA1 0.0017
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0017
2101 Glutathione-requiring prostaglandin D synthase HPGDS 0.0017
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0017
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0016
4226 Uridine phosphorylase 2 UPP2 0.0016
5432 Trafficking protein particle complex subunit 3 TRAPPC3 0.0016
2211 Fatty acid-binding protein, heart FABP3 0.0016
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0016
173 Toll-like receptor 7 TLR7 0.0016
3238 Multidrug resistance protein mexA mexA 0.0016
3709 Glycerol uptake facilitator protein glpF 0.0016
3116 Bacterioferritin bfr 0.0016
4906 Bacterioferritin bfr 0.0016
4965 Bacterioferritin bfr 0.0016
5489 Ribonucleoside-diphosphate reductase 1 subunit beta nrdB 0.0016
3173 Enolase eno 0.0016
3336 C4-dicarboxylate transport transcriptional regulatory protein dctD dctD 0.0016
3393 TGF-beta receptor type-2 TGFBR2 0.0016
6495 Cytochrome c oxidase subunit 7C, mitochondrial COX7C 0.0016
6497 Cytochrome c oxidase subunit 6A2, mitochondrial COX6A2 0.0015
6493 Cytochrome c oxidase subunit 6C COX6C 0.0015
6494 Cytochrome c oxidase subunit 7B, mitochondrial COX7B 0.0015
6498 Cytochrome c oxidase subunit 6B1 COX6B1 0.0015
6496 Cytochrome c oxidase subunit 8A, mitochondrial COX8A 0.0015
6499 Cytochrome c oxidase polypeptide 7A1, mitochondrial COX7A1 0.0015
6491 Cytochrome c oxidase subunit 5A, mitochondrial COX5A 0.0015
6489 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial COX4I1 0.0015
6490 Cytochrome c oxidase subunit 3 MT-CO3 0.0015
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.0015
6559 Cytochrome c oxidase subunit 2 ctaC 0.0015
6669 Cytochrome c oxidase subunit 2 ctaC 0.0015
3233 Bile acid receptor NR1H4 0.0015
371 Cytochrome c oxidase subunit 1 MT-CO1 0.0015
6558 Cytochrome c oxidase subunit 1 ctaD 0.0015
2408 Tyrosine-protein kinase SYK SYK 0.0015
2853 14 kDa fatty acid-binding protein Not Available 0.0015
6755 Poliovirus receptor PVR 0.0015
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0015
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0015
6677 Myelin P2 protein PMP2 0.0015
4225 Uridine phosphorylase 1 UPP1 0.0015
1525 Heparin-binding growth factor 2 FGF2 0.0015
1569 G1/S-specific cyclin-D1 CCND1 0.0015
4031 Glutathione S-transferase A1 GSTA1 0.0014
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0014
2540 Choloylglycine hydrolase cbh 0.0014
760 Fibroblast growth factor 1 FGF1 0.0014
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0014
1760 Aminopeptidase N ANPEP 0.0014
6843 Aminopeptidase N pepN 0.0014
2129 Sucrase-isomaltase, intestinal SI 0.0014
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.0014
413 Amidophosphoribosyltransferase PPAT 0.0014
2515 Amidophosphoribosyltransferase purF 0.0014
3714 Amidophosphoribosyltransferase purF 0.0014
117 Sterol O-acyltransferase 1 SOAT1 0.0014
2852 DNA mismatch repair protein mutL mutL 0.0014
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0013
3191 Histidinol dehydrogenase hisD 0.0013
6501 Fatty acid-binding protein, liver FABP1 0.0013
400 Coagulation factor IX F9 0.0013
5461 Coagulation factor IX F9 0.0013
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0013
1864 RET proto-oncogene RET 0.0013
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0013
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0013
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0013
6116 Gastric triacylglycerol lipase LIPF 0.0012
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0012
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0012
4692 A/G-specific adenine glycosylase mutY 0.0012
3382 Glycolipid transfer protein GLTP 0.0012
694 Matrix protein 2 M 0.0012
2240 Cell division protein kinase 2 CDK2 0.0012
85 Growth hormone receptor GHR 0.0012
1714 Mitogen-activated protein kinase 3 MAPK3 0.0012
2297 Genome polyprotein Not Available 0.0012
2322 Genome polyprotein Not Available 0.0012
2694 Genome polyprotein Not Available 0.0012
2719 Genome polyprotein Not Available 0.0012
2860 Genome polyprotein Not Available 0.0012
2928 Genome polyprotein Not Available 0.0012
3160 Genome polyprotein Not Available 0.0012
3260 Genome polyprotein Not Available 0.0012
4783 Genome polyprotein Not Available 0.0012
5726 Genome polyprotein Not Available 0.0012
5779 Genome polyprotein Not Available 0.0012
5867 Genome polyprotein Not Available 0.0012
6253 Genome polyprotein Not Available 0.0012
6301 Genome polyprotein Not Available 0.0012
6380 Genome polyprotein Not Available 0.0012
6381 Genome polyprotein Not Available 0.0012
6437 Genome polyprotein Not Available 0.0012
6520 Genome polyprotein Not Available 0.0012
6521 Genome polyprotein Not Available 0.0012
6652 Genome polyprotein Not Available 0.0012
6734 Genome polyprotein Not Available 0.0012
6735 Genome polyprotein Not Available 0.0012
6736 Genome polyprotein Not Available 0.0012
6737 Genome polyprotein Not Available 0.0012
6738 Genome polyprotein Not Available 0.0012
6739 Genome polyprotein Not Available 0.0012
6744 Genome polyprotein Not Available 0.0012
6748 Genome polyprotein Not Available 0.0012
6894 Genome polyprotein Not Available 0.0012
6898 Genome polyprotein Not Available 0.0012
338 DNA polymerase UL30 0.0012
379 DNA polymerase UL54 0.0012
697 DNA polymerase ORF28 0.0012
2482 DNA polymerase 43 0.0012
4104 DNA polymerase BALF5 0.0012
4948 Cytochrome c-553 Not Available 0.0012
4923 Cytochrome c3 DvMF_2499 0.0012
4945 Cytochrome c3 Not Available 0.0012
4949 Cytochrome c3 DVU_3171 0.0012
4968 Cytochrome c3 cytc3 0.0012
4997 Cytochrome c3 SO_2727 0.0012
5219 Cytochrome c3 cyd 0.0012
1295 Fatty acid synthase FASN 0.0012
4902 Nine-heme cytochrome c Ddes_2038 0.0012
3189 High-molecular-weight cytochrome c hmcA 0.0012
4081 Vitamin K epoxide reductase complex subunit 1-like protein 1 VKORC1L1 0.0012
604 Vitamin K-dependent protein Z PROZ 0.0012
6151 Monocarboxylate transporter 10 SLC16A10 0.0012
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0012
6859 Protein S100-A4 S100A4 0.0012
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0012
707 72 kDa type IV collagenase MMP2 0.0011
484 Tyrosine-protein kinase ABL2 ABL2 0.0011
6500 Phospholipase A2 PLA2G1B 0.0011
754 Pancreatic triacylglycerol lipase PNLIP 0.0011
2236 Casein kinase II subunit alpha CSNK2A1 0.0011
422 Vitamin K-dependent protein C PROC 0.0011
1245 Vitamin K-dependent protein S PROS1 0.0011
2802 Endoglucanase G celCCG 0.0011
6316 ADP-ribosylation factor 1 ARF1 0.0011
1810 Protein S100-A1 S100A1 0.001
6097 Protein S100-A2 S100A2 0.001
4228 Keratin, type II cytoskeletal 7 KRT7 0.001
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.001
1063 Signal transducer and activator of transcription 5B STAT5B 0.001
4386 Hemoglobin-like protein HbN glbN 0.001
3007 Carbonic anhydrase 12 CA12 0.001
4205 Carbonic anhydrase 9 CA9 0.001
493 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial CYP27B1 0.001
512 DNA-directed RNA polymerase alpha chain rpoA 0.001
5772 DNA-directed RNA polymerase alpha chain rpoA 0.001
1176 Mitogen-activated protein kinase 1 MAPK1 0.001
2473 Tyrosine-protein kinase CSK CSK 0.001
2398 Tyrosine-protein kinase ZAP-70 ZAP70 0.001
448 Vitamin K-dependent gamma-carboxylase GGCX 0.001
1928 Leukotriene C4 synthase LTC4S 0.001
4043 Glutaredoxin-2, mitochondrial GLRX2 0.001
4034 Glutaredoxin-1 GLRX 0.001
910 Epididymal secretory glutathione peroxidase GPX5 0.001
4036 Glutathione peroxidase 6 GPX6 0.001
4037 Hypothetical protein GPX1 0.001
4297 Hypothetical protein SP_1951 0.001
4521 Hypothetical protein BC_2969 0.001
4540 Hypothetical protein TM_1070 0.001
4555 Hypothetical protein MT1739 0.001
4569 Hypothetical protein mshD 0.001
4578 Hypothetical protein PA3270 0.001
4747 Hypothetical protein PA3967 0.001
5177 Hypothetical protein TM_0096 0.001
5194 Hypothetical protein PA1204 0.001
5240 Hypothetical protein Rv2991 0.001
5370 Hypothetical protein TM_1158 0.001
5710 Hypothetical protein Tb927.5.1360 0.001
4029 Microsomal glutathione S-transferase 3 MGST3 0.001
900 Glutathione S-transferase A4 GSTA4 0.001
4030 Thioredoxin domain-containing protein 12 TXNDC12 0.001
911 Glutathione peroxidase 3 GPX3 0.001
4040 Glutathione peroxidase 7 GPX7 0.001
907 Glutathione peroxidase 2 GPX2 0.001
4032 Microsomal glutathione S-transferase 1 MGST1 0.001
906 Glutathione peroxidase 1 GPX1 0.001
4039 CDNA FLJ23636 fis, clone CAS07176 GPX8 0.001
4035 Glutathione S-transferase Mu 5 GSTM5 0.001
903 Glutathione S-transferase A5 GSTA5 0.001
4042 Glutathione transferase omega-2 GSTO2 0.001
4033 S-formylglutathione hydrolase ESD 0.001
4038 Glutathione peroxidase 4 GPX4 0.001
1975 Phospholipid hydroperoxide glutathione peroxidase, mitochondrial GPX4 0.001
1056 Gamma-glutamyltranspeptidase 1 GGT1 0.001
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.001
2268 Cholesterol oxidase choB 0.0009
2822 Cholesterol oxidase choA 0.0009
997 Protein kinase C beta type PRKCB 0.0009
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0009
6105 3-oxo-5-beta-steroid 4-dehydrogenase AKR1D1 0.0009
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.0009
1048 Protein S100-A13 S100A13 0.0009
2226 Protein S100-A12 S100A12 0.0009
3319 Hydroxyacylglutathione hydrolase HAGH 0.0009
798 Osteocalcin BGLAP 0.0009
898 Glutathione S-transferase A3 GSTA3 0.0009
2283 Steroid Delta-isomerase ksi 0.0009
2920 Steroid Delta-isomerase ksi 0.0009
897 Glutathione S-transferase kappa 1 GSTK1 0.0009
1970 Protein kinase C alpha type PRKCA 0.0009
909 Maleylacetoacetate isomerase GSTZ1 0.0009
6171 Solute carrier family 28 member 3 SLC28A3 0.0009
2132 Protein S100-B S100B 0.0009
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0008
899 Glutathione S-transferase Mu 3 GSTM3 0.0008
905 Glutathione transferase omega-1 GSTO1 0.0008
22 30S ribosomal protein S4 rpsD 0.0008
6714 30S ribosomal protein S4 rpsD 0.0008
2325 Sulfotransferase family cytosolic 2B member 1 SULT2B1 0.0008
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0008
4954 Soluble cytochrome b558 Not Available 0.0008
4925 Cytochrome c-type protein SHP shp 0.0008
4916 Cyanoglobin glbN 0.0008
4947 Bacterial hemoglobin vhb 0.0008
4915 Cytochrome c-550 psbV 0.0008
4959 Cytochrome c-550 psbV 0.0008
5216 Cytochrome c-550 psbV 0.0008
4934 Cytochrome c-551 nirM 0.0008
5218 Cytochrome c-551 nirM 0.0008
4943 Cytochrome c6 petJ 0.0008
4975 Cytochrome c-556 RPA3973 0.0008
4936 Cytochrome c2 iso-2 Not Available 0.0008
4994 Hemoglobin-like protein HbO glbO 0.0008
4905 Cytochrome c2 Not Available 0.0008
4939 Cytochrome c2 cycA 0.0008
4964 Cytochrome c2 cycA 0.0008
4979 Cytochrome c2 cycA 0.0008
6673 Cytochrome c2 cycA 0.0008
4984 Neuroglobin NGB 0.0008
4998 Hemoglobin-like protein yjbI yjbI 0.0008
5000 HemO hemO 0.0008
4910 Cytoglobin CYGB 0.0008
4909 CooA protein cooA 0.0008
4981 Iron-starvation protein PigA pigA 0.0008
4907 Cytochrome c-L moxG 0.0008
6865 Cytochrome c-L moxG 0.0008
644 Heme oxygenase 2 HMOX2 0.0008
4982 Heme oxygenase 2 pbsA2 0.0008
4942 Diheme cytochrome c napB napB 0.0008
4935 Cytochrome c-554 cycA1 0.0008
4961 Hemophore HasA hasA 0.0008
4904 Cytochrome c family protein GSU1996 0.0008
4971 Nonaheme cytochrome c hmcA 0.0008
4976 Apocytochrome f petA 0.0008
6407 Apocytochrome f petA 0.0008
4764 Cytochrome P450 165C4 CYP165C4 0.0008
4999 Cytochrome P450 165B3 CYP165B3 0.0008
4960 Putative cytochrome P450-family protein SCO7417 0.0008
4931 Cytochrome P450 167A1 CYP167A1 0.0008
4989 Cytochrome c551 peroxidase ccp 0.0008
5222 Cytochrome c551 peroxidase ccpA 0.0008
4937 Cytochrome oxidase subunit II rcoxA 0.0008
4972 P450cin cinA 0.0008
4903 Methyl-accepting chemotaxis protein Tar4 0.0008
4926 Heme-based aerotactic transducer hemAT hemAT 0.0008
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0008
4922 Cytochrome c, putative SO_4144 0.0008
4993 Hydroxylamine oxidoreductase hao1 0.0008
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0008
3093 Catalase HPII katE 0.0008
4952 Catalase/peroxidase katA 0.0008
369 Coagulation factor VII F7 0.0008
1867 Major prion protein PRNP 0.0008
2165 Glutathione S-transferase Mu 2 GSTM2 0.0008
1507 Cytochrome c CYCS 0.0008
1649 Small inducible cytokine A2 CCL2 0.0008
2530 Protein kinase C theta type PRKCQ 0.0008
207 Glutathione synthetase GSS 0.0008
5269 Glutathione synthetase gshB 0.0008
1025 Aquaporin-1 AQP1 0.0008
3830 Calreticulin CALR 0.0008
2091 Endoplasmin HSP90B1 0.0008
901 Glutathione S-transferase Mu 4 GSTM4 0.0007
6034 Hydroxyindole O-methyltransferase ASMT 0.0007
6035 Nuclear receptor ROR-beta RORB 0.0007
6036 Eosinophil peroxidase EPX 0.0007
6207 30S ribosomal protein S14 rpsN 0.0007
6209 30S ribosomal protein S19 rpsS 0.0007
6712 30S ribosomal protein S19 rpsS 0.0007
6726 30S ribosomal protein S19 rpsS 0.0007
645 Penicillin-binding protein 1A mrcA 0.0007
5805 Penicillin-binding protein 1A ponA 0.0007
6185 Penicillin-binding protein 1A mrcA 0.0007
6799 Penicillin-binding protein 1A pbpA 0.0007
2511 MAP kinase-activated protein kinase 2 MAPKAPK2 0.0007
226 Gonadotropin-releasing hormone receptor GNRHR 0.0007
1830 5'-nucleotidase NT5E 0.0007
125 DNA polymerase beta POLB 0.0007
714 Glutathione reductase, mitochondrial GSR 0.0006
765 Indoleamine 2,3-dioxygenase IDO1 0.0006
3426 Glutamine synthetase glnA 0.0006
3987 Glutamine synthetase GLUL 0.0006
4920 Peroxidase/catalase katG 0.0006
2119 Cytochrome b5 CYB5A 0.0006
4990 PpcA ppcA 0.0006
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0006
3375 Acidic cytochrome c3 Not Available 0.0006
4988 Sulfite oxidase, mitochondrial SUOX 0.0006
2915 Sensor protein fixL fixL 0.0006
4944 Sensor protein fixL fixL 0.0006
4385 Cytochrome c' Not Available 0.0006
4967 Cytochrome c' cycA 0.0006
5038 Cytochrome c' Not Available 0.0006
5223 Cytochrome c' cycP 0.0006
3570 Cytochrome P450 152A1 cypC 0.0006
4813 Heme oxygenase hmuO 0.0006
5769 Heme oxygenase Not Available 0.0006
4289 Cytochrome P450 TT_P0059 0.0006
6262 Cytochrome P450 staP 0.0006
4992 Cytochrome c peroxidase Not Available 0.0006
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.0006
5221 Cytochrome c3, 13 kDa Not Available 0.0006
3152 Cytochrome c'' cycA 0.0006
5220 Split-Soret cytochrome c Ddes_2150 0.0006
3700 Cytochrome c-552 precursor nrfA 0.0006
1721 Glycogen synthase kinase-3 beta GSK3B 0.0005
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0005
3411 Cytochrome P450 121 cyp121 0.0005
3670 Soluble cytochrome b562 precursor cybC 0.0005
3291 Cytochrome c-552 cycA 0.0005
4927 Cytochrome c-552 nrfA 0.0005
4938 Cytochrome c-552 cycA 0.0005
4953 Cytochrome c-552 nrfA 0.0005
5217 Cytochrome c-552 cycM 0.0005
2617 Nitric oxide synthase oxygenase nos 0.0005
2701 Nitric oxide synthase oxygenase nos 0.0005
3102 Flavohemoprotein hmp 0.0005
4969 Flavohemoprotein hmp 0.0005
3127 Nitrite reductase nirS 0.0005
3284 Nitrite reductase nirS 0.0005
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0005
2972 6-deoxyerythronolide B hydroxylase eryF 0.0005
4608 Putative cytochrome P450 SCO1207 0.0004
4963 Putative cytochrome P450 SCO2884 0.0004
6254 Putative cytochrome P450 SCO6998 0.0004
3405 Quinohaemoprotein ethanol dehydrogenase type-1 qheDH 0.0004
693 Hemoglobin subunit beta HBB 0.0004
340 Apoptotic protease-activating factor 1 APAF1 0.0004
6268 Hydroxyacid oxidase 1 HAO1 0.0004
810 Heme oxygenase 1 HMOX1 0.0004
3391 Heme oxygenase 1 pbsA1 0.0004
825 Arsenical pump-driving ATPase ASNA1 0.0003
3435 Arsenical pump-driving ATPase arsA 0.0003
486 Serine/threonine-protein kinase ALS2CR7 CDK15 0.0003
2105 ATP-binding cassette sub-family G member 1 ABCG1 0.0003
377 Beta-adrenergic receptor kinase 1 ADRBK1 0.0003
510 Serine/threonine-protein kinase receptor R3 ACVRL1 0.0003
733 Activin receptor type 1B ACVR1B 0.0003
225 NEDD8-activating enzyme E1 regulatory subunit NAE1 0.0003
745 Anti-Muellerian hormone type-2 receptor AMHR2 0.0003
483 A-Raf proto-oncogene serine/threonine-protein kinase ARAF 0.0003
21 Beta-adrenergic receptor kinase 2 ADRBK2 0.0003
154 AFG3-like protein 2 AFG3L2 0.0003
395 ALK tyrosine kinase receptor Not Available 0.0003
292 Activin receptor type-1 ACVR1 0.0003
849 Activated CDC42 kinase 1 TNK2 0.0003
704 Long-chain-fatty-acid--CoA ligase 1 ACSL1 0.0003
821 Acetyl-coenzyme A synthetase 2-like, mitochondrial ACSS1 0.0003
386 Acetyl-coenzyme A synthetase, cytoplasmic ACSS2 0.0003
297 Adenylate cyclase type 1 ADCY1 0.0003
289 Cytosolic purine 5'-nucleotidase NT5C2 0.0003
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.0003
740 Argininosuccinate synthase ASS1 0.0002
865 Argininosuccinate synthase ASS1 0.0002
2680 Argininosuccinate synthase argG 0.0002
3194 Argininosuccinate synthase argG 0.0002
661 ADP/ATP translocase 1 SLC25A4 0.0002
6021 Adenosine kinase ADK 0.0002
242 Asparagine synthetase [glutamine-hydrolyzing] ASNS 0.0002
6135 Sodium channel subunit beta-4 SCN4B 0.0002
6134 Sodium channel subunit beta-3 SCN3B 0.0002
6132 Sodium channel subunit beta-1 SCN1B 0.0002
6127 Carbonic anhydrase-related protein CA8 0.0002
6128 Carbonic anhydrase-related protein 10 CA10 0.0002
6133 Sodium channel subunit beta-2 SCN2B 0.0002
6129 Carbonic anhydrase-related protein 11 CA11 0.0002
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0002
6130 Carbonic anhydrase 13 CA13 0.0002
↑