DT-Web

DB00257 - Clotrimazole


Identification
Name Clotrimazole
Accession Number DB00257 (APRD00244)
Type small molecule
Description An imidazole derivative with a broad spectrum of antimycotic activity. It inhibits biosynthesis of the sterol ergostol, an important component of fungal cell membranes. Its action leads to increased membrane permeability and apparent disruption of enzyme systems bound to the membrane. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 344.837
Groups approved
Monoisotopic Weight 344.108026261
Pharmacology
Indication For the local treatment of oropharyngeal candidiasis and vaginal yeast infections, also used in fungal infections of the skin such as ringworm, athlete's foot, and jock itch.
Mechanism of action Clotrimazole interacts with yeast 14-α demethylase, a cytochrome P-450 enzyme that converts lanosterol to ergosterol, an essential component of the membrane. In this way, clotrimazole inhibits ergosterol synthesis, resulting in increased cellular permeability. Clotrimazole may also inhibit endogenous respiration, interact with membrane phospholipids, inhibit the transformation of yeasts to mycelial forms and the uptake of purine, impair triglyceride and/or phospholipid biosynthesis, and inhibit the movement of calcium and potassium ions across the cell membrane by blocking the ion transport pathway known as the Gardos channel.
Absorption Poorly and erratically absorbed orally, minimal vaginal or topical absorption.
Protein binding 90%
Biotransformation Hepatic (metabolized to inactive metabolites)
Route of elimination Not Available
Toxicity Symptoms of overdose include erythema, stinging, blistering, peeling, edema, pruritus, urticaria, burning, and general irritation of the skin, and cramps.
Affected organisms
  • Yeast and other fungi
Interactions
Drug Interactions
Drug Mechanism of interaction
Alvimopan Decreases levels by P-glycoprotein (MDR-1) efflux transporter. Can significantly increase systemic exposure to P-glycoprotein substrates.
Budesonide CYP3A4 Inhibitors (Moderate) such as clotrimazole may increase the serum concentration of Budesonide (Systemic, Oral Inhalation). Consider reducing the oral budesonide dose when used together with a CYP3A4 inhibitor. This interaction is likely less severe with orally inhaled budesonide. Any patient receiving both budesonide and a moderate CYP3A4 inhibitor should be monitored closely for signs/symptoms of corticosteroid excess.
Colchicine CYP3A4 Inhibitors (Moderate) such as clotrimazole may increase the serum concentration of colchicine. Reduce colchicine dose (for gout flares: to 1.2 mg x 1 dose, with next dose no sooner than 3 days later; for Familial Mediterranean Fever: to no more than 1.2 mg/day) when using in combination with a moderate CYP3A4 inhibitor such as erythromycin or verapamil. Increase monitoring for colchicine-related toxicity when using such combinations. Use extra caution in patients with impaired renal and/or hepatic function.
Everolimus CYP3A4 Inhibitors (Moderate)such as clotrimazole may increase the serum concentration of everolimus. The prescribing information for the Afinitor branded everolimus product lists indication-specific recommendations for managing this interaction.
Fentanyl CYP3A4 Inhibitors (Moderate) such as clotrimazole may increase the serum concentration of fentanyl. Concurrent use of fentanyl with any CYP3A4 inhibitor may result in increased fentanyl concentrations and could increase or prolong adverse effects, including potentially fatal respiratory depression. Patients receiving fentanyl and any CYP3A4 inhibitor should be closely monitored for several days following initiation of the combination, and fentanyl dosage reductions should be made as appropriate.
Halofantrine CYP3A4 Inhibitors (Moderate) such as clotrmazole may increase the serum concentration of halofantrine. Extreme caution, with possibly increased monitoring of cardiac status (e.g., ECG), should be used with concurrent use of halofantrine with any moderate CYP3A4 inhibitor(s).
Lurasidone CYP3A4 Inhibitors (Moderate) such as clotrimazole may increase the serum concentration of lurasidone. Limit adult lurasidone dose to 40 mg/day in patients receiving a moderate CYP3A4 inhibitor.
Ranolazine CYP3A4 Inhibitors (Moderate) such as clotrimazole may increase the serum concentration of ranolazine. Limit the ranolazine dose to a maximum of 500mg twice daily in patients concurrently receiving moderate CYP3A4 inhibitors (e.g., diltiazem, verapamil, erythromycin, etc.). Monitor for increased effects/toxicity of ranolazine during concomitant use.
Tacrolimus The antifungal, Clotrimazole, may increase serum concentrations of Tacrolimus. Monitor for changes in the therapeutic/toxic effects of Tacrolimus if Clotrimazole therapy is initiated, discontinued or altered.
Tamsulosin Clotrimazole, a CYP3A4 inhibitor, may decrease the metabolism and clearance of Tamsulosin, a CYP3A4 substrate. Monitor for changes in therapeutic/adverse effects of Tamsulosin if Clotrimazole is initiated, discontinued, or dose changed.
Tolterodine Clotrimazole may decrease the metabolism and clearance of Tolterodine. Adjust Tolterodine dose and monitor for efficacy and toxicity.
Tolvaptan CYP3A4 Inhibitors (Moderate) may increase the serum concentration of tolvaptan. Coadministration of a strong CYP3A4 inhibitor with tolvaptan is contraindicated.
Tramadol Clotrimazole may increase Tramadol toxicity by decreasing Tramadol metabolism and clearance.
Trazodone The CYP3A4 inhibitor, Clotrimazole, may increase Trazodone efficacy/toxicity by decreasing Trazodone metabolism and clearance. Monitor for changes in Trazodone efficacy/toxicity if Clotrimazole is initiated, discontinued or dose changed.
Food Interactions Not Available

Targets


Cytochrome P450 51
Name Cytochrome P450 51
Gene Name ERG11
Pharmacological action yes
Actions antagonist,inhibitor
References
  • Warrilow AG, Martel CM, Parker JE, Melo N, Lamb DC, Nes WD, Kelly DE, Kelly SL: Azole binding properties of Candida albicans sterol 14-alpha demethylase (CaCYP51). Antimicrob Agents Chemother. 2010 Oct;54(10):4235-45. Epub 2010 Jul 12. - Pubmed
  • Gachotte D, Pierson CA, Lees ND, Barbuch R, Koegel C, Bard M: A yeast sterol auxotroph (erg25) is rescued by addition of azole antifungals and reduced levels of heme. Proc Natl Acad Sci U S A. 1997 Oct 14;94(21):11173-8. - Pubmed
  • Henry KW, Nickels JT, Edlind TD: Upregulation of ERG genes in Candida species by azoles and other sterol biosynthesis inhibitors. Antimicrob Agents Chemother. 2000 Oct;44(10):2693-700. - Pubmed
  • Lorenz RT, Parks LW: Physiological effects of fenpropimorph on wild-type Saccharomyces cerevisiae and fenpropimorph-resistant mutants. Antimicrob Agents Chemother. 1991 Aug;35(8):1532-7. - Pubmed
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 0.5258
Intermediate conductance calcium-activated potassium channel protein 4
Name Intermediate conductance calcium-activated potassium channel protein 4
Gene Name KCNN4
Pharmacological action yes
Actions inhibitor
References
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
  • Brugnara C, Gee B, Armsby CC, Kurth S, Sakamoto M, Rifai N, Alper SL, Platt OS: Therapy with oral clotrimazole induces inhibition of the Gardos channel and reduction of erythrocyte dehydration in patients with sickle cell disease. J Clin Invest. 1996 Mar 1;97(5):1227-34. - Pubmed
DTHybrid score 0.1283

Enzymes


Cytochrome P450 2C8
Name Cytochrome P450 2C8
Gene Name CYP2C8
Actions inhibitor
References
  • Walsky RL, Gaman EA, Obach RS: Examination of 209 drugs for inhibition of cytochrome P450 2C8. J Clin Pharmacol. 2005 Jan;45(1):68-78. - Pubmed
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.6033
Cytochrome P450 3A4
Name Cytochrome P450 3A4
Gene Name CYP3A4
Actions inhibitor,inducer
References
  • Bjornsson TD, Callaghan JT, Einolf HJ, Fischer V, Gan L, Grimm S, Kao J, King SP, Miwa G, Ni L, Kumar G, McLeod J, Obach SR, Roberts S, Roe A, Shah A, Snikeris F, Sullivan JT, Tweedie D, Vega JM, Walsh J, Wrighton SA: The conduct of in vitro and in vivo drug-drug interaction studies: a PhRMA perspective. J Clin Pharmacol. 2003 May;43(5):443-69. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 1.1736
Cytochrome P450 2B6
Name Cytochrome P450 2B6
Gene Name CYP2B6
Actions inhibitor,inducer
References
  • Walsky RL, Astuccio AV, Obach RS: Evaluation of 227 drugs for in vitro inhibition of cytochrome P450 2B6. J Clin Pharmacol. 2006 Dec;46(12):1426-38. - Pubmed
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.5397
Cholesterol side-chain cleavage enzyme, mitochondrial
Name Cholesterol side-chain cleavage enzyme, mitochondrial
Gene Name CYP11A1
Actions inhibitor
References
  • Mason JI, Murry BA, Olcott M, Sheets JJ: Imidazole antimycotics: inhibitors of steroid aromatase. Biochem Pharmacol. 1985 Apr 1;34(7):1087-92. - Pubmed
DTHybrid score 0.2536
Cytochrome P450 1A2
Name Cytochrome P450 1A2
Gene Name CYP1A2
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.7069
Cytochrome P450 2D6
Name Cytochrome P450 2D6
Gene Name CYP2D6
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.7688
Cytochrome P450 11B1, mitochondrial
Name Cytochrome P450 11B1, mitochondrial
Gene Name CYP11B1
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.272
Cytochrome P450 19A1
Name Cytochrome P450 19A1
Gene Name CYP19A1
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.5275
Cytochrome P450 2A6
Name Cytochrome P450 2A6
Gene Name CYP2A6
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.4825
Cytochrome P450 2C19
Name Cytochrome P450 2C19
Gene Name CYP2C19
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.751
Cytochrome P450 2C9
Name Cytochrome P450 2C9
Gene Name CYP2C9
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.8174
Cytochrome P450 2E1
Name Cytochrome P450 2E1
Gene Name CYP2E1
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.5345
Cytochrome P450 3A7
Name Cytochrome P450 3A7
Gene Name CYP3A7
Actions inducer
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.4412

Transporters


Canalicular multispecific organic anion transporter 2
Name Canalicular multispecific organic anion transporter 2
Gene Name ABCC3
Actions inducer
References
  • Teng S, Jekerle V, Piquette-Miller M: Induction of ABCC3 (MRP3) by pregnane X receptor activators. Drug Metab Dispos. 2003 Nov;31(11):1296-9. - Pubmed
DTHybrid score 0.1989
Multidrug resistance protein 1
Name Multidrug resistance protein 1
Gene Name ABCB1
Actions inhibitor,inducer
References
  • Geick A, Eichelbaum M, Burk O: Nuclear receptor response elements mediate induction of intestinal MDR1 by rifampin. J Biol Chem. 2001 May 4;276(18):14581-7. Epub 2001 Jan 31. - Pubmed
  • Schuetz EG, Beck WT, Schuetz JD: Modulators and substrates of P-glycoprotein and cytochrome P4503A coordinately up-regulate these proteins in human colon carcinoma cells. Mol Pharmacol. 1996 Feb;49(2):311-8. - Pubmed
  • Ekins S, Kim RB, Leake BF, Dantzig AH, Schuetz EG, Lan LB, Yasuda K, Shepard RL, Winter MA, Schuetz JD, Wikel JH, Wrighton SA: Three-dimensional quantitative structure-activity relationships of inhibitors of P-glycoprotein. Mol Pharmacol. 2002 May;61(5):964-73. - Pubmed
  • Schwab D, Fischer H, Tabatabaei A, Poli S, Huwyler J: Comparison of in vitro P-glycoprotein screening assays: recommendations for their use in drug discovery. J Med Chem. 2003 Apr 24;46(9):1716-25. - Pubmed
  • Bain LJ, LeBlanc GA: Interaction of structurally diverse pesticides with the human MDR1 gene product P-glycoprotein. Toxicol Appl Pharmacol. 1996 Nov;141(1):288-98. - Pubmed
  • Yasuda K, Lan LB, Sanglard D, Furuya K, Schuetz JD, Schuetz EG: Interaction of cytochrome P450 3A inhibitors with P-glycoprotein. J Pharmacol Exp Ther. 2002 Oct;303(1):323-32. - Pubmed
DTHybrid score 0.7265
Canalicular multispecific organic anion transporter 1
Name Canalicular multispecific organic anion transporter 1
Gene Name ABCC2
Actions inducer
References
  • Kauffmann HM, Pfannschmidt S, Zoller H, Benz A, Vorderstemann B, Webster JI, Schrenk D: Influence of redox-active compounds and PXR-activators on human MRP1 and MRP2 gene expression. Toxicology. 2002 Feb 28;171(2-3):137-46. - Pubmed
DTHybrid score 0.3279

Predictions


Id Partner name Gene Name Score
761 Cytochrome P450 51 ERG11 0.5258
3163 Cytochrome P450 51 cyp51 0.5258
4118 Cytochrome P450 3A5 CYP3A5 0.4752
6024 Cytochrome P450 1A1 CYP1A1 0.265
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.211
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.1823
587 Serum albumin ALB 0.1786
20 Prostaglandin G/H synthase 1 PTGS1 0.1612
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.1486
862 Multidrug resistance-associated protein 1 ABCC1 0.1371
6106 Cytochrome P450 2C18 CYP2C18 0.1275
1010 Cytochrome P450 51A1 CYP51A1 0.1206
776 Bile salt export pump ABCB11 0.1151
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.1149
492 Histamine H1 receptor HRH1 0.1103
146 Androgen receptor AR 0.108
1898 Cytochrome P450 1B1 CYP1B1 0.106
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.1031
2164 Multidrug resistance-associated protein 4 ABCC4 0.103
6145 Solute carrier family 22 member 1 SLC22A1 0.1023
1729 Solute carrier family 22 member 6 SLC22A6 0.101
136 Estrogen receptor ESR1 0.0998
824 Sodium-dependent serotonin transporter SLC6A4 0.0976
1181 Alpha-1-acid glycoprotein 1 ORM1 0.093
6144 Solute carrier family 22 member 2 SLC22A2 0.0912
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0893
756 Sex hormone-binding globulin SHBG 0.0872
118 Organic cation/carnitine transporter 2 SLC22A5 0.0846
831 D(2) dopamine receptor DRD2 0.0822
290 Prostaglandin G/H synthase 2 PTGS2 0.0798
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0788
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0773
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0766
502 5-hydroxytryptamine 2A receptor HTR2A 0.0753
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0729
556 Alpha-1A adrenergic receptor ADRA1A 0.0715
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0706
380 Cytochrome P450 17A1 CYP17A1 0.0705
6142 Solute carrier family 22 member 8 SLC22A8 0.0705
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0681
6143 Solute carrier family 22 member 7 SLC22A7 0.0664
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0631
871 Glucocorticoid receptor NR3C1 0.0613
847 Mu-type opioid receptor OPRM1 0.0609
3941 Amine oxidase [flavin-containing] A MAOA 0.0589
766 Beta-2 adrenergic receptor ADRB2 0.0569
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0568
6031 Cytochrome P450 3A43 CYP3A43 0.0557
468 Cytochrome P450 4A11 CYP4A11 0.0553
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0549
713 Sodium-dependent dopamine transporter SLC6A3 0.0538
731 HIV-1 protease HIV-1 protease 0.0538
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0531
6147 Solute carrier family 22 member 3 SLC22A3 0.0529
833 Organic cation/carnitine transporter 1 SLC22A4 0.0523
318 Alpha-2A adrenergic receptor ADRA2A 0.0519
590 5-hydroxytryptamine 2C receptor HTR2C 0.0515
817 DNA topoisomerase 2-alpha TOP2A 0.051
6148 Multidrug resistance-associated protein 7 ABCC10 0.0503
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.05
320 5-hydroxytryptamine 1A receptor HTR1A 0.0495
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0489
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0482
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0477
465 Calmodulin CALM1 0.0473
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.047
23 D(1A) dopamine receptor DRD1 0.0469
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0464
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0462
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0456
467 Delta-type opioid receptor OPRD1 0.0452
6136 Multidrug resistance-associated protein 5 ABCC5 0.045
193 Beta-1 adrenergic receptor ADRB1 0.0449
6141 Sodium/bile acid cotransporter SLC10A1 0.0448
3939 Amine oxidase [flavin-containing] B MAOB 0.0447
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0447
341 5-hydroxytryptamine 3 receptor HTR3A 0.044
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0439
737 Mineralocorticoid receptor NR3C2 0.0436
632 Alpha-1B adrenergic receptor ADRA1B 0.0433
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0429
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0416
3923 Cholinesterase BCHE 0.0414
696 Kappa-type opioid receptor OPRK1 0.0414
629 Alpha-2B adrenergic receptor ADRA2B 0.0413
6137 Multidrug resistance-associated protein 6 ABCC6 0.041
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0408
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0406
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0405
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0404
1024 Solute carrier family 22 member 11 SLC22A11 0.0394
614 Progesterone receptor PGR 0.0389
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0366
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0362
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0362
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0362
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0362
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.036
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.036
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.036
269 Adrenodoxin, mitochondrial FDX1 0.0358
70 Type-1 angiotensin II receptor AGTR1 0.0357
885 5-hydroxytryptamine 1B receptor HTR1B 0.0352
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0351
94 5-hydroxytryptamine 4 receptor HTR4 0.0347
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0346
6182 Cytochrome P450 2J2 CYP2J2 0.0346
638 D(3) dopamine receptor DRD3 0.0346
477 DNA topoisomerase 4 subunit A parC 0.0345
886 DNA topoisomerase 4 subunit A parC 0.0345
6226 DNA topoisomerase 4 subunit A parC 0.0345
232 Corticosteroid-binding globulin SERPINA6 0.034
404 DNA gyrase subunit A gyrA 0.034
6224 DNA gyrase subunit A gyrA 0.034
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.033
4116 Dihydropteroate synthetase Not Available 0.033
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0327
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0327
563 Thyroid peroxidase TPO 0.0322
6014 Cytochrome P450 2A13 CYP2A13 0.032
482 Glycine receptor subunit alpha-1 GLRA1 0.0317
4604 Liver carboxylesterase 1 CES1 0.0313
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0309
122 P2Y purinoceptor 12 P2RY12 0.0308
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0304
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0304
976 Platelet glycoprotein IX GP9 0.03
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0298
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0296
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0296
24 Thymidylate synthase TMP1 0.0295
359 Thymidylate synthase TYMS 0.0295
2626 Thymidylate synthase thyA 0.0295
2729 Thymidylate synthase thyA 0.0295
5352 Thymidylate synthase THYA 0.0295
869 Estrogen receptor beta ESR2 0.0293
789 Alpha-1D adrenergic receptor ADRA1D 0.0293
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0291
725 5-hydroxytryptamine 1D receptor HTR1D 0.029
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0289
537 ATP synthase delta chain, mitochondrial ATP5D 0.0289
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0286
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0286
891 Dihydropteroate synthase folP 0.0276
5359 Dihydropteroate synthase folP 0.0276
7175 Dihydropteroate synthase sulI 0.0276
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0273
3947 Xanthine dehydrogenase/oxidase XDH 0.0272
7 Nitric oxide synthase, inducible NOS2 0.0272
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0266
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0265
5934 Cytochrome P450 26A1 CYP26A1 0.0264
36 Insulin receptor INSR 0.0258
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0256
1680 Solute carrier family 2, facilitated glucose transporter member 1 SLC2A1 0.0255
469 Annexin A1 ANXA1 0.0252
161 Tubulin beta chain TUBB 0.0251
312 Tubulin beta chain TUB2 0.0251
4120 NADPH--cytochrome P450 reductase POR 0.0249
6102 Arylamine N-acetyltransferase 2 NAT2 0.0246
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0243
2298 Cytochrome P450-cam camC 0.0242
504 Mast/stem cell growth factor receptor KIT 0.0241
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0239
844 Epidermal growth factor receptor EGFR 0.0236
811 Translocator protein TSPO 0.0236
1757 Myeloperoxidase MPO 0.0235
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0232
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0232
777 Tumor necrosis factor TNF 0.0232
378 Alpha-2C adrenergic receptor ADRA2C 0.0229
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0228
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0228
1656 CYP2B protein CYP2B 0.0225
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0225
124 Histamine H2 receptor HRH2 0.0224
1178 Adenosine A2a receptor ADORA2A 0.0223
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0223
432 D(4) dopamine receptor DRD4 0.022
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0217
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0217
6167 Organic solute transporter subunit beta OSTB 0.0216
436 5-hydroxytryptamine 2B receptor HTR2B 0.0216
6166 Organic solute transporter subunit alpha OSTA 0.0216
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0214
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0212
6220 Aryl hydrocarbon receptor AHR 0.021
6044 Serum paraoxonase/lactonase 3 PON3 0.0207
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0207
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0206
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0206
1268 Neuropeptide S receptor NPSR1 0.0206
634 Squalene monooxygenase SQLE 0.0205
7196 Squalene monooxygenase ERG1 0.0205
738 Monocarboxylate transporter 1 SLC16A1 0.0204
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0203
6020 Aldehyde oxidase AOX1 0.0202
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0202
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0202
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0202
226 Gonadotropin-releasing hormone receptor GNRHR 0.02
29 Tubulin beta-1 chain TUBB1 0.0199
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0199
442 Envelope glycoprotein gp41 0.0198
4859 Envelope glycoprotein env 0.0198
16 Adenosine A1 receptor ADORA1 0.0196
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0195
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0195
716 5-hydroxytryptamine 7 receptor HTR7 0.0194
26 Vascular endothelial growth factor receptor 3 FLT4 0.0194
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0192
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0192
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0192
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0192
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0192
1192 Sulfotransferase 1A1 SULT1A1 0.0191
606 Cytochrome P450 27, mitochondrial CYP27A1 0.019
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.019
291 Nitric-oxide synthase, endothelial NOS3 0.0189
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0188
407 Vascular endothelial growth factor receptor 2 KDR 0.0187
474 Acetylcholinesterase ACHE 0.0186
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0186
32 Vascular endothelial growth factor receptor 1 FLT1 0.0185
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0183
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0183
228 Beta platelet-derived growth factor receptor PDGFRB 0.0182
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0182
904 Glutathione S-transferase P GSTP1 0.0182
818 50S ribosomal protein L10 rplJ 0.0181
275 Arachidonate 5-lipoxygenase ALOX5 0.018
84 Nuclear receptor 0B1 NR0B1 0.018
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0179
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0179
908 Glutathione S-transferase theta-1 GSTT1 0.0178
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0178
3810 Catechol O-methyltransferase COMT 0.0177
705 Glutamate receptor 1 GRIA1 0.0176
6073 Potassium channel subfamily K member 9 KCNK9 0.0176
6072 Potassium channel subfamily K member 3 KCNK3 0.0176
6085 Fatty acid-binding protein, intestinal FABP2 0.0175
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0175
148 Lutropin-choriogonadotropic hormone receptor LHCGR 0.0175
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0173
373 Transthyretin TTR 0.0172
3917 Methylenetetrahydrofolate reductase MTHFR 0.017
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0166
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0165
921 Glutamate receptor 2 GRIA2 0.0164
365 Dihydrofolate reductase DHFR 0.0163
2381 Dihydrofolate reductase DFR1 0.0163
2833 Dihydrofolate reductase Not Available 0.0163
2931 Dihydrofolate reductase folA 0.0163
3544 Dihydrofolate reductase folA 0.0163
3682 Dihydrofolate reductase folA 0.0163
6642 Dihydrofolate reductase folA 0.0163
6756 Dihydrofolate reductase dfrA 0.0163
3809 Estrogen-related receptor gamma ESRRG 0.0162
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.016
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0156
13 Aminomethyltransferase, mitochondrial AMT 0.0154
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0153
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0151
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0151
131 Synaptic vesicular amine transporter SLC18A2 0.0151
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.015
2539 Tubulin alpha-1 chain TUBA4A 0.015
581 Cytochrome P450 2R1 CYP2R1 0.015
273 Apoptosis regulator Bcl-2 BCL2 0.015
427 Substance-P receptor TACR1 0.0149
571 Melatonin receptor type 1A MTNR1A 0.0148
362 Melatonin receptor type 1B MTNR1B 0.0148
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0147
4237 50S ribosomal protein L22 rplV 0.0146
4148 Serine/threonine-protein kinase mTOR MTOR 0.0146
174 Sigma 1-type opioid receptor SIGMAR1 0.0145
952 Dipeptidyl peptidase 4 DPP4 0.0145
4122 Histone deacetylase 2 HDAC2 0.0145
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0145
596 3-oxo-5-alpha-steroid 4-dehydrogenase 1 SRD5A1 0.0144
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0143
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0143
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0143
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0142
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.014
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.014
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0139
163 D(1B) dopamine receptor DRD5 0.0138
88 Retinoic acid receptor RXR-beta RXRB 0.0138
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0138
4238 50S ribosomal protein L4 rplD 0.0138
5578 50S ribosomal protein L4 rplD 0.0138
6173 50S ribosomal protein L4 rplD 0.0138
6219 50S ribosomal protein L4 rplD 0.0138
6146 High affinity copper uptake protein 1 SLC31A1 0.0137
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0137
295 Carbonic anhydrase 1 CA1 0.0135
2207 Rhodopsin RHO 0.0134
3957 Adenosine deaminase ADA 0.0133
3932 Glutathione S-transferase A2 GSTA2 0.0133
185 Vasopressin V1a receptor AVPR1A 0.0131
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.013
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.013
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.013
1992 Vitamin D-binding protein GC 0.013
856 Vitamin D3 receptor VDR 0.0129
780 Retinoic acid receptor RXR-gamma RXRG 0.0128
1852 Microtubule-associated protein 2 MAP2 0.0128
322 Vasopressin V2 receptor AVPR2 0.0128
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0127
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0127
1256 5-hydroxytryptamine 6 receptor HTR6 0.0127
284 DNA-directed RNA polymerase beta chain rpoB 0.0126
5773 DNA-directed RNA polymerase beta chain rpoB 0.0126
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0126
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0126
528 5-hydroxytryptamine 1E receptor HTR1E 0.0126
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0126
117 Sterol O-acyltransferase 1 SOAT1 0.0125
1629 Transcription factor AP-1 JUN 0.0123
518 Peroxidase/catalase T katG 0.0122
251 Alcohol dehydrogenase 1A ADH1A 0.0121
1650 Heme carrier protein 1 SLC46A1 0.0121
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0119
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0119
444 Alcohol dehydrogenase 1B ADH1B 0.0119
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0117
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0117
2808 Chloramphenicol acetyltransferase 3 cat3 0.0116
592 Carbonic anhydrase 4 CA4 0.0116
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0116
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0115
165 FL cytokine receptor FLT3 0.0115
6149 Solute carrier family 22 member 10 SLC22A10 0.0115
517 Alcohol dehydrogenase 1C ADH1C 0.0115
1050 Bile salt sulfotransferase SULT2A1 0.0114
2230 Catalase CAT 0.0114
3249 Catalase katA 0.0114
3625 Catalase katA 0.0114
4539 Catalase katA 0.0114
4941 Catalase katB 0.0114
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.0113
162 Retinoic acid receptor gamma-1 RARG 0.0112
1435 Synaptic vesicle glycoprotein 2A SV2A 0.0112
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0112
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0111
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0111
293 Gamma-glutamyl hydrolase GGH 0.0111
5923 Microtubule-associated protein tau MAPT 0.0111
5924 Microtubule-associated protein 4 MAP4 0.0111
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0111
890 Niemann-Pick C1-like protein 1 NPC1L1 0.011
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.011
2443 Azurin azu 0.0108
613 Atrial natriuretic peptide receptor A NPR1 0.0106
896 Glutathione S-transferase Mu 1 GSTM1 0.0106
6138 Multidrug resistance protein 3 ABCB4 0.0105
319 Opioid receptor, sigma 1 OPRS1 0.0103
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0103
6432 Transporter snf 0.0103
5626 Nucleoside diphosphate kinase B NME2 0.0102
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0102
6165 Copper-transporting ATPase 1 ATP7A 0.0102
6163 Copper-transporting ATPase 2 ATP7B 0.0102
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0101
357 Carbonic anhydrase 2 CA2 0.0101
4192 DNA topoisomerase 2-beta TOP2B 0.0099
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0098
68 Cannabinoid receptor 1 CNR1 0.0097
1760 Aminopeptidase N ANPEP 0.0097
6843 Aminopeptidase N pepN 0.0097
958 Insulin-like growth factor 1 receptor IGF1R 0.0097
1353 DNA topoisomerase 1 TOP1 0.0096
3552 DNA topoisomerase 1 topA 0.0096
49 Endothelin B receptor EDNRB 0.0096
511 5-hydroxytryptamine 1F receptor HTR1F 0.0095
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0095
1618 High affinity nerve growth factor receptor NTRK1 0.0094
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0094
4773 Deoxycytidine kinase DCK 0.0094
2449 Tubulin alpha-3 chain TUBA1A 0.0093
814 Ryanodine receptor 1 RYR1 0.0093
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0092
823 Fibroblast growth factor receptor 2 FGFR2 0.0091
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0091
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0091
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0091
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0091
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0091
578 Endothelin-1 receptor EDNRA 0.009
1630 Integrin beta-2 ITGB2 0.0089
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.0088
459 Retinoic acid receptor RXR-alpha RXRA 0.0088
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0087
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0087
208 DNA-directed RNA polymerase beta' chain rpoC 0.0087
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0087
6043 Putative G-protein coupled receptor 44 GPR44 0.0086
33 Cystine/glutamate transporter SLC7A11 0.0086
299 Folate receptor beta FOLR2 0.0086
718 Folate receptor gamma FOLR3 0.0086
804 Mitochondrial folate transporter/carrier SLC25A32 0.0086
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0086
6174 50S ribosomal protein L32 rpmF 0.0086
4226 Uridine phosphorylase 2 UPP2 0.0085
229 Retinoic acid receptor beta RARB 0.0084
6126 Carbonic anhydrase 7 CA7 0.0084
5294 Nucleoside diphosphate kinase A NME1 0.0083
1275 Estrogen sulfotransferase SULT1E1 0.0083
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0083
730 Retinoic acid receptor alpha RARA 0.0083
183 Vascular endothelial growth factor A VEGFA 0.0082
850 Vasopressin V1b receptor AVPR1B 0.0081
1517 Beta-3 adrenergic receptor ADRB3 0.0081
4203 Histamine N-methyltransferase HNMT 0.0081
565 Extracellular calcium-sensing receptor CASR 0.008
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0079
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0079
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0079
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0079
2112 Toll-like receptor 9 TLR9 0.0079
239 Coagulation factor X F10 0.0079
173 Toll-like receptor 7 TLR7 0.0079
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0078
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0078
4225 Uridine phosphorylase 1 UPP1 0.0078
2183 Fatty acid-binding protein, adipocyte FABP4 0.0077
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.0077
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0076
244 Angiotensin-converting enzyme ACE 0.0076
723 Cytosolic phospholipase A2 PLA2G4A 0.0076
144 Hemoglobin subunit alpha HBA1 0.0076
558 Solute carrier family 12 member 1 SLC12A1 0.0075
2981 Phospholipase A2, membrane associated PLA2G2A 0.0075
768 FK506-binding protein 1A FKBP1A 0.0074
1541 Metalloproteinase mmp20 0.0074
3639 Thymidine phosphorylase deoA 0.0074
3936 Thymidine phosphorylase TYMP 0.0074
413 Amidophosphoribosyltransferase PPAT 0.0073
2515 Amidophosphoribosyltransferase purF 0.0073
3714 Amidophosphoribosyltransferase purF 0.0073
153 Dopamine beta-hydroxylase DBH 0.0073
106 Cannabinoid receptor 2 CNR2 0.0072
3937 Fatty-acid amide hydrolase FAAH 0.0071
790 DNA polymerase subunit alpha B POLA2 0.0071
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0071
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0071
5300 Antigen peptide transporter 1 TAP1 0.0071
4311 tRNA TRDMT1 0.0071
4325 tRNA trmD 0.0071
4328 tRNA trmD 0.0071
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.007
1483 Membrane copper amine oxidase AOC3 0.007
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.007
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.007
3587 Gastrotropin FABP6 0.007
1649 Small inducible cytokine A2 CCL2 0.007
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0069
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0069
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0069
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0069
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0069
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0069
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0069
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0069
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0069
1636 Trace amine-associated receptor 1 TAAR1 0.0067
702 UMP-CMP kinase CMPK1 0.0067
3808 Dihydropteroate synthase 2 folP2 0.0067
3601 Dihydropteroate synthase 1 folP1 0.0067
3807 Dihydropteroate synthase 1 folP1 0.0067
4103 Proteasome subunit beta type 2 PSMB2 0.0066
4102 Proteasome subunit beta type 5 PSMB5 0.0066
4101 Proteasome subunit beta type 1 PSMB1 0.0066
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0066
342 P protein [Includes: DNA-directed DNA polymerase P 0.0066
612 P protein [Includes: DNA-directed DNA polymerase P 0.0066
6766 O-GlcNAcase BT_4395 BT_4395 0.0066
6218 Pannexin-1 PANX1 0.0066
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0065
2499 Tubulin beta-2C chain TUBB2C 0.0065
751 Potassium channel subfamily K member 6 KCNK6 0.0065
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0065
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0064
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0064
1196 Complement decay-accelerating factor CD55 0.0064
267 Plasminogen activator inhibitor 1 SERPINE1 0.0064
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0064
1648 Elastin ELN 0.0063
3432 Multidrug-efflux transporter 1 regulator bmrR 0.0063
4476 Mannitol dehydrogenase mtlD 0.0063
489 Monocarboxylate transporter 2 SLC16A7 0.0063
133 Dihydropterate synthase sulI 0.0063
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0063
982 Cocaine- and amphetamine-regulated transcript protein CARTPT 0.0062
3270 Elongation factor G fusA 0.0062
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0062
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0061
54 Prothrombin F2 0.0061
172 Potassium channel subfamily K member 1 KCNK1 0.006
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0059
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0059
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0059
2232 Interleukin-5 IL5 0.0059
3830 Calreticulin CALR 0.0059
1593 Mucin-2 MUC2 0.0059
6221 Steroid hormone receptor ERR1 ESRRA 0.0058
5880 Thrombopoietin receptor MPL 0.0058
714 Glutathione reductase, mitochondrial GSR 0.0058
3856 Fibroblast growth factor receptor 3 FGFR3 0.0057
572 Integrin alpha-L ITGAL 0.0057
719 Retinoic acid receptor responder protein 1 RARRES1 0.0057
770 Retinoic acid-induced protein 3 GPRC5A 0.0057
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0055
1313 Lactoylglutathione lyase GLO1 0.0055
3913 Glutamic acid decarboxylase GAD65 0.0055
642 3-oxo-5-alpha-steroid 4-dehydrogenase 2 SRD5A2 0.0055
6034 Hydroxyindole O-methyltransferase ASMT 0.0055
6035 Nuclear receptor ROR-beta RORB 0.0055
6036 Eosinophil peroxidase EPX 0.0055
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0055
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0055
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0055
686 Aldo-keto reductase family 1 member C2 AKR1C2 0.0055
6506 Stathmin-4 STMN4 0.0055
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0055
461 Glycine receptor subunit alpha-3 GLRA3 0.0054
164 Histamine H4 receptor HRH4 0.0054
65 Matrix metalloproteinase-9 Not Available 0.0054
992 Protein tyrosine kinase 2 beta PTK2B 0.0054
4217 Telomerase reverse transcriptase TERT 0.0053
390 Adenosine A3 receptor ADORA3 0.0053
5998 Toll-like receptor 8 TLR8 0.0053
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0052
1262 Corticotropin-lipotropin POMC 0.0052
5787 Angiopoietin-1 receptor TEK 0.0052
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0052
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0052
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0052
712 Tubulin alpha chain TUB1 0.0052
3090 Chitosanase csn 0.0052
4149 Nuclear factor NF-kappa-B p100 subunit NFKB2 0.0052
6168 Solute carrier family 22 member 16 SLC22A16 0.0052
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.0051
3823 Cytokine receptor common gamma chain IL2RG 0.0051
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0051
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0051
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0051
2417 Chloramphenicol acetyltransferase cat 0.0051
3278 Chloramphenicol acetyltransferase cat 0.0051
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0051
2810 Dr hemagglutinin structural subunit draA 0.005
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.005
569 Retinal dehydrogenase 2 ALDH1A2 0.005
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.005
6042 Prostaglandin reductase 2 PTGR2 0.0049
6599 HTH-type transcriptional regulator ttgR ttgR 0.0049
1360 Sphingomyelin phosphodiesterase SMPD1 0.0049
1123 Eosinophil cationic protein RNASE3 0.0049
3404 Exotoxin A eta 0.0049
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0048
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.0048
765 Indoleamine 2,3-dioxygenase IDO1 0.0048
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0048
611 Retinal dehydrogenase 1 ALDH1A1 0.0047
2616 Ganglioside GM2 activator GM2A 0.0047
683 Potassium transporter GK0582 0.0047
1253 Interferon gamma IFNG 0.0046
4228 Keratin, type II cytoskeletal 7 KRT7 0.0046
3904 Alanine aminotransferase 2 GPT2 0.0046
735 Alanine aminotransferase 1 GPT 0.0046
527 Prostacyclin receptor PTGIR 0.0045
1039 Histone deacetylase 9 HDAC9 0.0045
6211 Tubulin epsilon chain TUBE1 0.0045
6210 Tubulin delta chain TUBD1 0.0045
6212 Tubulin gamma-1 chain TUBG1 0.0045
3086 Plasmepsin-2 Not Available 0.0045
724 Interleukin-2 receptor alpha chain IL2RA 0.0045
717 Interleukin-2 receptor subunit beta IL2RB 0.0045
2178 Metabotropic glutamate receptor 5 GRM5 0.0045
820 Glycine receptor subunit alpha-2 GLRA2 0.0045
2599 Tyrosine-protein kinase HCK HCK 0.0044
1714 Mitogen-activated protein kinase 3 MAPK3 0.0044
1374 Natriuretic peptides B NPPB 0.0044
1827 Gap junction alpha-1 protein GJA1 0.0044
1908 Vascular cell adhesion protein 1 VCAM1 0.0044
130 Prostacyclin synthase PTGIS 0.0044
936 Ephrin type-A receptor 2 EPHA2 0.0043
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0043
473 L-lactate dehydrogenase A chain LDHA 0.0042
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0042
5818 Folate receptor alpha FOLR1 0.0042
2320 Thymidine kinase, cytosolic TK1 0.0042
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0042
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0042
1569 G1/S-specific cyclin-D1 CCND1 0.0041
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0041
6048 Troponin C, skeletal muscle TNNC2 0.0041
3997 Cytochrome P450 24A1, mitochondrial CYP24A1 0.0041
400 Coagulation factor IX F9 0.004
5461 Coagulation factor IX F9 0.004
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.004
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.004
268 Adenosine A2b receptor ADORA2B 0.004
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0039
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0039
2268 Cholesterol oxidase choB 0.0039
2822 Cholesterol oxidase choA 0.0039
1864 RET proto-oncogene RET 0.0039
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0039
6105 3-oxo-5-beta-steroid 4-dehydrogenase AKR1D1 0.0039
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0039
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0039
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0039
2290 ADP-ribosyl cyclase 2 BST1 0.0039
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.0039
1129 C-C chemokine receptor type 5 CCR5 0.0039
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0038
4164 Potassium voltage-gated channel subfamily KQT member 5 KCNQ5 0.0038
4163 Potassium voltage-gated channel subfamily KQT member 4 KCNQ4 0.0038
605 Fumarate reductase flavoprotein subunit frdA 0.0038
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0038
3673 Fumarate reductase flavoprotein subunit fccA 0.0038
4912 Fumarate reductase flavoprotein subunit ifcA 0.0038
6549 Fumarate reductase flavoprotein subunit frdA 0.0038
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0038
2391 Ferrochelatase hemH 0.0038
6502 Ferrochelatase DKFZp686P18130 0.0038
1591 Ferrochelatase, mitochondrial FECH 0.0038
6824 Tyrosine-protein kinase Lyn LYN 0.0038
85 Growth hormone receptor GHR 0.0038
594 Thyroxine-binding globulin SERPINA7 0.0037
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0037
76 Nitric-oxide synthase, brain NOS1 0.0037
6103 Arylamine N-acetyltransferase 1 NAT1 0.0037
4081 Vitamin K epoxide reductase complex subunit 1-like protein 1 VKORC1L1 0.0037
604 Vitamin K-dependent protein Z PROZ 0.0037
5798 Mitogen-activated protein kinase 11 MAPK11 0.0037
2283 Steroid Delta-isomerase ksi 0.0037
2920 Steroid Delta-isomerase ksi 0.0037
2782 Complement C1s subcomponent C1S 0.0037
633 Penicillin-binding proteins 1A/1B pbpA 0.0036
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.0036
6837 Serine/threonine-protein kinase 17B STK17B 0.0036
543 Penicillin-binding protein 1B mrcB 0.0035
6186 Penicillin-binding protein 1B ponB 0.0035
6822 Penicillin-binding protein 1b pbp1b 0.0035
6844 Penicillin-binding protein 1b pbp1b 0.0035
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0035
2300 Lysozyme E 0.0035
3633 Lysozyme R 0.0035
5597 Lysozyme 17 0.0035
159 Penicillin-binding protein 2B penA 0.0035
6121 Penicillin-binding protein 2B penA 0.0035
939 50S ribosomal protein L3 rplC 0.0035
758 Thyroid hormone receptor alpha THRA 0.0034
3815 Complement C1q subcomponent subunit A C1QA 0.0034
3816 Complement C1q subcomponent subunit B C1QB 0.0034
3817 Complement C1q subcomponent subunit C C1QC 0.0034
2325 Sulfotransferase family cytosolic 2B member 1 SULT2B1 0.0034
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0034
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0034
3818 Low affinity immunoglobulin gamma Fc region receptor III-A FCGR3A 0.0034
3819 Low affinity immunoglobulin gamma Fc region receptor II-a FCGR2A 0.0034
1102 Low affinity immunoglobulin gamma Fc region receptor III-B FCGR3B 0.0034
3821 Low affinity immunoglobulin gamma Fc region receptor II-c FCGR2C 0.0034
3814 Complement C1r subcomponent C1R 0.0034
1245 Vitamin K-dependent protein S PROS1 0.0034
422 Vitamin K-dependent protein C PROC 0.0034
3820 Low affinity immunoglobulin gamma Fc region receptor II-b FCGR2B 0.0034
6496 Cytochrome c oxidase subunit 8A, mitochondrial COX8A 0.0033
6499 Cytochrome c oxidase polypeptide 7A1, mitochondrial COX7A1 0.0033
6495 Cytochrome c oxidase subunit 7C, mitochondrial COX7C 0.0033
6497 Cytochrome c oxidase subunit 6A2, mitochondrial COX6A2 0.0033
6493 Cytochrome c oxidase subunit 6C COX6C 0.0033
6494 Cytochrome c oxidase subunit 7B, mitochondrial COX7B 0.0033
6498 Cytochrome c oxidase subunit 6B1 COX6B1 0.0033
6491 Cytochrome c oxidase subunit 5A, mitochondrial COX5A 0.0033
6489 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial COX4I1 0.0033
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.0033
6559 Cytochrome c oxidase subunit 2 ctaC 0.0033
6669 Cytochrome c oxidase subunit 2 ctaC 0.0033
6490 Cytochrome c oxidase subunit 3 MT-CO3 0.0033
371 Cytochrome c oxidase subunit 1 MT-CO1 0.0033
6558 Cytochrome c oxidase subunit 1 ctaD 0.0033
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0033
1525 Heparin-binding growth factor 2 FGF2 0.0033
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0032
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0032
784 High affinity immunoglobulin gamma Fc receptor I FCGR1A 0.0032
2107 Microtubule-associated protein 1A MAP1A 0.0032
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0032
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0032
140 30S ribosomal protein S9 rpsI 0.0031
6719 30S ribosomal protein S9 rpsI 0.0031
6725 30S ribosomal protein S9 rpsI 0.0031
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0031
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.0031
1227 Cytochrome b MT-CYB 0.0031
6386 Cytochrome b petB 0.0031
6937 Cytochrome b MT-CYB 0.0031
674 Dihydroorotate dehydrogenase homolog, mitochondrial PFF0160c 0.0031
78 Acetyl-CoA acetyltransferase, mitochondrial ACAT1 0.0031
4041 Microsomal glutathione S-transferase 2 MGST2 0.0031
346 Thyroid hormone receptor beta-1 THRB 0.0031
2578 Tubulin beta-3 chain TUBB3 0.003
2285 Streptogramin A acetyltransferase vatD 0.003
448 Vitamin K-dependent gamma-carboxylase GGCX 0.003
2540 Choloylglycine hydrolase cbh 0.003
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.003
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.003
3611 Cytidine deaminase cdd 0.003
3707 Cytidine deaminase cdd 0.003
4211 Cytidine deaminase CDA 0.003
512 DNA-directed RNA polymerase alpha chain rpoA 0.0029
5772 DNA-directed RNA polymerase alpha chain rpoA 0.0029
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0029
233 Potassium channel subfamily K member 2 KCNK2 0.0029
6459 Glycodelin PAEP 0.0028
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.0028
1291 cAMP response element-binding protein CREB1 0.0028
6501 Fatty acid-binding protein, liver FABP1 0.0028
330 Spermidine synthase SRM 0.0028
3038 Spermidine synthase speE 0.0028
1200 AMBP protein AMBP 0.0028
3866 Serum amyloid A protein SAA1 0.0028
1932 Apolipoprotein E APOE 0.0028
798 Osteocalcin BGLAP 0.0028
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.0027
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0027
1176 Mitogen-activated protein kinase 1 MAPK1 0.0027
6232 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short GNAS 0.0027
6233 Adenylate cyclase type 2 ADCY2 0.0027
6234 Adenylate cyclase type 5 ADCY5 0.0027
199 Monocarboxylate transporter 8 SLC16A2 0.0027
1144 Hepatocyte growth factor receptor MET 0.0027
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0027
4210 Toll-like receptor 4 TLR4 0.0027
4173 Tyrosine-protein kinase JAK2 JAK2 0.0027
2159 Quinone oxidoreductase CRYZ 0.0027
358 Cystathionine beta-synthase CBS 0.0027
3849 Insulin-like growth factor-binding protein 7 IGFBP7 0.0027
2009 Protein NOV homolog NOV 0.0027
3847 Neuroendocrine convertase 2 PCSK2 0.0027
1949 Carboxypeptidase E CPE 0.0027
3850 Synaptotagmin-like protein 4 SYTL4 0.0027
3848 Neuroendocrine convertase 1 PCSK1 0.0027
3846 Retinoblastoma-associated protein RB1 0.0027
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0026
2101 Glutathione-requiring prostaglandin D synthase HPGDS 0.0026
5997 Tumor necrosis factor ligand superfamily member 11 TNFSF11 0.0026
2216 Fibroblast growth factor receptor 4 FGFR4 0.0026
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.0026
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.0025
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.0025
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0025
6859 Protein S100-A4 S100A4 0.0025
484 Tyrosine-protein kinase ABL2 ABL2 0.0025
2021 Thrombomodulin THBD 0.0025
1385 Angiotensin-converting enzyme 2 ACE2 0.0025
6033 High affinity interleukin-8 receptor A CXCR1 0.0025
369 Coagulation factor VII F7 0.0025
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0024
4034 Glutaredoxin-1 GLRX 0.0024
1928 Leukotriene C4 synthase LTC4S 0.0024
907 Glutathione peroxidase 2 GPX2 0.0024
4043 Glutaredoxin-2, mitochondrial GLRX2 0.0024
4037 Hypothetical protein GPX1 0.0024
4297 Hypothetical protein SP_1951 0.0024
4521 Hypothetical protein BC_2969 0.0024
4540 Hypothetical protein TM_1070 0.0024
4555 Hypothetical protein MT1739 0.0024
4569 Hypothetical protein mshD 0.0024
4578 Hypothetical protein PA3270 0.0024
4747 Hypothetical protein PA3967 0.0024
5177 Hypothetical protein TM_0096 0.0024
5194 Hypothetical protein PA1204 0.0024
5240 Hypothetical protein Rv2991 0.0024
5370 Hypothetical protein TM_1158 0.0024
5710 Hypothetical protein Tb927.5.1360 0.0024
4029 Microsomal glutathione S-transferase 3 MGST3 0.0024
4032 Microsomal glutathione S-transferase 1 MGST1 0.0024
4030 Thioredoxin domain-containing protein 12 TXNDC12 0.0024
4040 Glutathione peroxidase 7 GPX7 0.0024
910 Epididymal secretory glutathione peroxidase GPX5 0.0024
903 Glutathione S-transferase A5 GSTA5 0.0024
4038 Glutathione peroxidase 4 GPX4 0.0024
1975 Phospholipid hydroperoxide glutathione peroxidase, mitochondrial GPX4 0.0024
906 Glutathione peroxidase 1 GPX1 0.0024
4033 S-formylglutathione hydrolase ESD 0.0024
4039 CDNA FLJ23636 fis, clone CAS07176 GPX8 0.0024
4035 Glutathione S-transferase Mu 5 GSTM5 0.0024
4036 Glutathione peroxidase 6 GPX6 0.0024
900 Glutathione S-transferase A4 GSTA4 0.0024
911 Glutathione peroxidase 3 GPX3 0.0024
4042 Glutathione transferase omega-2 GSTO2 0.0024
1056 Gamma-glutamyltranspeptidase 1 GGT1 0.0024
334 S-adenosylmethionine synthetase isoform type-2 MAT2A 0.0024
4031 Glutathione S-transferase A1 GSTA1 0.0024
544 Potassium voltage-gated channel subfamily E member 1 KCNE1 0.0024
6039 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A PDE11A 0.0024
6500 Phospholipase A2 PLA2G1B 0.0024
6070 Nischarin NISCH 0.0024
5852 Type-2 angiotensin II receptor AGTR2 0.0024
760 Fibroblast growth factor 1 FGF1 0.0024
1770 Phospholipase C PLCL1 0.0024
2841 Phospholipase C plc 0.0024
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0024
4221 Vascular endothelial growth factor VEGF 0.0023
5816 Cadherin-5 CDH5 0.0023
550 Amiloride-sensitive sodium channel subunit delta SCNN1D 0.0023
27 Amiloride-sensitive sodium channel subunit beta SCNN1B 0.0023
552 Amiloride-sensitive sodium channel subunit gamma SCNN1G 0.0023
213 Amiloride-sensitive sodium channel subunit alpha SCNN1A 0.0023
1830 5'-nucleotidase NT5E 0.0023
453 S-adenosylmethionine synthetase isoform type-1 MAT1A 0.0023
1341 Histamine H3 receptor HRH3 0.0023
6131 Carbonic anhydrase 14 CA14 0.0023
3221 Cytochrome c4 cc4 0.0023
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.0022
707 72 kDa type IV collagenase MMP2 0.0022
113 S-adenosylmethionine decarboxylase proenzyme AMD1 0.0022
3319 Hydroxyacylglutathione hydrolase HAGH 0.0022
898 Glutathione S-transferase A3 GSTA3 0.0022
897 Glutathione S-transferase kappa 1 GSTK1 0.0022
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.0022
411 Glycine N-methyltransferase GNMT 0.0022
2155 Insulin-degrading enzyme IDE 0.0022
909 Maleylacetoacetate isomerase GSTZ1 0.0021
298 Renin REN 0.0021
6122 Carbonic anhydrase 3 CA3 0.0021
2091 Endoplasmin HSP90B1 0.0021
905 Glutathione transferase omega-1 GSTO1 0.0021
899 Glutathione S-transferase Mu 3 GSTM3 0.0021
1244 Low-density lipoprotein receptor-related protein 2 LRP2 0.0021
63 Malate dehydrogenase mdh 0.0021
2329 Malate dehydrogenase mdh 0.0021
3445 Malate dehydrogenase mdh 0.0021
4420 Malate dehydrogenase mdh 0.0021
4438 Malate dehydrogenase mdh 0.0021
828 Phenylalanine-4-hydroxylase PAH 0.0021
3109 Phenylalanine-4-hydroxylase phhA 0.0021
5433 UPF0230 protein TM_1468 TM_1468 0.002
3616 Fatty acid-binding protein, epidermal FABP5 0.002
5431 Lipid binding protein Not Available 0.002
5430 Hepatocyte nuclear factor 4-gamma HNF4G 0.002
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.002
1820 Beta-nerve growth factor NGF 0.002
2236 Casein kinase II subunit alpha CSNK2A1 0.0019
2165 Glutathione S-transferase Mu 2 GSTM2 0.0019
207 Glutathione synthetase GSS 0.0019
5269 Glutathione synthetase gshB 0.0019
3426 Glutamine synthetase glnA 0.0019
3987 Glutamine synthetase GLUL 0.0019
893 [Citrate [pro-3S]-lyase] ligase citC 0.0018
845 Pyruvate dehydrogenase [cytochrome] poxB 0.0018
3920 Methylenetetrahydrofolate reductase intermediate form MTHFR 0.0018
3763 5,10-methylenetetrahydrofolate reductase metF 0.0018
3918 5,10-methylenetetrahydrofolate reductase MTHFR 0.0018
5094 5,10-methylenetetrahydrofolate reductase metF 0.0018
59 AMT protein AMT 0.0018
3919 Methionyl-tRNA formyltransferase, mitochondrial MTFMT 0.0018
1202 10-formyltetrahydrofolate dehydrogenase ALDH1L1 0.0018
901 Glutathione S-transferase Mu 4 GSTM4 0.0018
1968 ATP-sensitive inward rectifier potassium channel 12 KCNJ12 0.0018
327 Glutathione reductase gor 0.0018
5110 Glutathione reductase GR2 0.0018
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0018
1063 Signal transducer and activator of transcription 5B STAT5B 0.0018
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.0017
1792 Tissue-type plasminogen activator PLAT 0.0017
283 SEC14-like protein 2 SEC14L2 0.0017
6151 Monocarboxylate transporter 10 SLC16A10 0.0017
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0017
1243 Cathepsin D CTSD 0.0016
5432 Trafficking protein particle complex subunit 3 TRAPPC3 0.0016
2211 Fatty acid-binding protein, heart FABP3 0.0016
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0016
3238 Multidrug resistance protein mexA mexA 0.0016
3709 Glycerol uptake facilitator protein glpF 0.0016
3116 Bacterioferritin bfr 0.0016
4906 Bacterioferritin bfr 0.0016
4965 Bacterioferritin bfr 0.0016
5489 Ribonucleoside-diphosphate reductase 1 subunit beta nrdB 0.0016
3173 Enolase eno 0.0016
3336 C4-dicarboxylate transport transcriptional regulatory protein dctD dctD 0.0016
3393 TGF-beta receptor type-2 TGFBR2 0.0016
3233 Bile acid receptor NR1H4 0.0015
296 Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial MTHFD2 0.0015
2408 Tyrosine-protein kinase SYK SYK 0.0015
2853 14 kDa fatty acid-binding protein Not Available 0.0015
6755 Poliovirus receptor PVR 0.0015
6677 Myelin P2 protein PMP2 0.0015
340 Apoptotic protease-activating factor 1 APAF1 0.0015
3844 HLA class II histocompatibility antigen, DQ(6) alpha chain HLA-DQA2 0.0015
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0015
3884 SHMT2 protein SHMT2 0.0014
3901 SHMT2 protein SHMT2 0.0014
3885 Hypothetical protein DKFZp686P09201 DKFZp686P09201 0.0014
3879 Serine hydroxymethyltransferase 2 Not Available 0.0014
321 Serine hydroxymethyltransferase, mitochondrial SHMT2 0.0014
2129 Sucrase-isomaltase, intestinal SI 0.0014
2852 DNA mismatch repair protein mutL mutL 0.0014
914 Formimidoyltransferase-cyclodeaminase FTCD 0.0014
3007 Carbonic anhydrase 12 CA12 0.0014
4205 Carbonic anhydrase 9 CA9 0.0014
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0013
679 C-1-tetrahydrofolate synthase, cytoplasmic MTHFD1 0.0013
3191 Histidinol dehydrogenase hisD 0.0013
809 Methionine synthase MTR 0.0013
2935 Methionine synthase metH 0.0013
6228 Nuclear receptor coactivator 1 NCOA1 0.0013
825 Arsenical pump-driving ATPase ASNA1 0.0013
3435 Arsenical pump-driving ATPase arsA 0.0013
486 Serine/threonine-protein kinase ALS2CR7 CDK15 0.0013
510 Serine/threonine-protein kinase receptor R3 ACVRL1 0.0013
2105 ATP-binding cassette sub-family G member 1 ABCG1 0.0013
745 Anti-Muellerian hormone type-2 receptor AMHR2 0.0013
483 A-Raf proto-oncogene serine/threonine-protein kinase ARAF 0.0013
733 Activin receptor type 1B ACVR1B 0.0013
225 NEDD8-activating enzyme E1 regulatory subunit NAE1 0.0013
154 AFG3-like protein 2 AFG3L2 0.0013
377 Beta-adrenergic receptor kinase 1 ADRBK1 0.0013
21 Beta-adrenergic receptor kinase 2 ADRBK2 0.0013
395 ALK tyrosine kinase receptor Not Available 0.0013
6241 Nuclear receptor coactivator 2 NCOA2 0.0013
860 Nicotinamide N-methyltransferase NNMT 0.0013
699 Nicotinic acid receptor 1 GPR109A 0.0013
928 Nicotinic acid receptor 2 GPR109B 0.0013
583 Nicotinate-nucleotide pyrophosphorylase [carboxylating] QPRT 0.0013
2442 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
2459 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
6116 Gastric triacylglycerol lipase LIPF 0.0012
367 Serine hydroxymethyltransferase, cytosolic SHMT1 0.0012
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0012
4692 A/G-specific adenine glycosylase mutY 0.0012
3382 Glycolipid transfer protein GLTP 0.0012
694 Matrix protein 2 M 0.0012
2240 Cell division protein kinase 2 CDK2 0.0012
2297 Genome polyprotein Not Available 0.0012
2322 Genome polyprotein Not Available 0.0012
2694 Genome polyprotein Not Available 0.0012
2719 Genome polyprotein Not Available 0.0012
2860 Genome polyprotein Not Available 0.0012
2928 Genome polyprotein Not Available 0.0012
3160 Genome polyprotein Not Available 0.0012
3260 Genome polyprotein Not Available 0.0012
4783 Genome polyprotein Not Available 0.0012
5726 Genome polyprotein Not Available 0.0012
5779 Genome polyprotein Not Available 0.0012
5867 Genome polyprotein Not Available 0.0012
6253 Genome polyprotein Not Available 0.0012
6301 Genome polyprotein Not Available 0.0012
6380 Genome polyprotein Not Available 0.0012
6381 Genome polyprotein Not Available 0.0012
6437 Genome polyprotein Not Available 0.0012
6520 Genome polyprotein Not Available 0.0012
6521 Genome polyprotein Not Available 0.0012
6652 Genome polyprotein Not Available 0.0012
6734 Genome polyprotein Not Available 0.0012
6735 Genome polyprotein Not Available 0.0012
6736 Genome polyprotein Not Available 0.0012
6737 Genome polyprotein Not Available 0.0012
6738 Genome polyprotein Not Available 0.0012
6739 Genome polyprotein Not Available 0.0012
6744 Genome polyprotein Not Available 0.0012
6748 Genome polyprotein Not Available 0.0012
6894 Genome polyprotein Not Available 0.0012
6898 Genome polyprotein Not Available 0.0012
338 DNA polymerase UL30 0.0012
379 DNA polymerase UL54 0.0012
697 DNA polymerase ORF28 0.0012
2482 DNA polymerase 43 0.0012
4104 DNA polymerase BALF5 0.0012
292 Activin receptor type-1 ACVR1 0.0012
4948 Cytochrome c-553 Not Available 0.0012
4923 Cytochrome c3 DvMF_2499 0.0012
4945 Cytochrome c3 Not Available 0.0012
4949 Cytochrome c3 DVU_3171 0.0012
4968 Cytochrome c3 cytc3 0.0012
4997 Cytochrome c3 SO_2727 0.0012
5219 Cytochrome c3 cyd 0.0012
1295 Fatty acid synthase FASN 0.0012
4902 Nine-heme cytochrome c Ddes_2038 0.0012
3189 High-molecular-weight cytochrome c hmcA 0.0012
849 Activated CDC42 kinase 1 TNK2 0.0012
704 Long-chain-fatty-acid--CoA ligase 1 ACSL1 0.0011
821 Acetyl-coenzyme A synthetase 2-like, mitochondrial ACSS1 0.0011
386 Acetyl-coenzyme A synthetase, cytoplasmic ACSS2 0.0011
297 Adenylate cyclase type 1 ADCY1 0.0011
289 Cytosolic purine 5'-nucleotidase NT5C2 0.0011
754 Pancreatic triacylglycerol lipase PNLIP 0.0011
2802 Endoglucanase G celCCG 0.0011
6316 ADP-ribosylation factor 1 ARF1 0.0011
1810 Protein S100-A1 S100A1 0.001
6097 Protein S100-A2 S100A2 0.001
4386 Hemoglobin-like protein HbN glbN 0.001
493 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial CYP27B1 0.001
2473 Tyrosine-protein kinase CSK CSK 0.001
2398 Tyrosine-protein kinase ZAP-70 ZAP70 0.001
740 Argininosuccinate synthase ASS1 0.001
865 Argininosuccinate synthase ASS1 0.001
2680 Argininosuccinate synthase argG 0.001
3194 Argininosuccinate synthase argG 0.001
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.001
661 ADP/ATP translocase 1 SLC25A4 0.0009
6021 Adenosine kinase ADK 0.0009
997 Protein kinase C beta type PRKCB 0.0009
242 Asparagine synthetase [glutamine-hydrolyzing] ASNS 0.0009
1064 DNA (cytosine-5)-methyltransferase 1 DNMT1 0.0009
1048 Protein S100-A13 S100A13 0.0009
2226 Protein S100-A12 S100A12 0.0009
1970 Protein kinase C alpha type PRKCA 0.0009
6171 Solute carrier family 28 member 3 SLC28A3 0.0009
2132 Protein S100-B S100B 0.0009
22 30S ribosomal protein S4 rpsD 0.0008
6714 30S ribosomal protein S4 rpsD 0.0008
4954 Soluble cytochrome b558 Not Available 0.0008
4925 Cytochrome c-type protein SHP shp 0.0008
4916 Cyanoglobin glbN 0.0008
4947 Bacterial hemoglobin vhb 0.0008
4915 Cytochrome c-550 psbV 0.0008
4959 Cytochrome c-550 psbV 0.0008
5216 Cytochrome c-550 psbV 0.0008
4934 Cytochrome c-551 nirM 0.0008
5218 Cytochrome c-551 nirM 0.0008
4943 Cytochrome c6 petJ 0.0008
4975 Cytochrome c-556 RPA3973 0.0008
4936 Cytochrome c2 iso-2 Not Available 0.0008
4994 Hemoglobin-like protein HbO glbO 0.0008
4905 Cytochrome c2 Not Available 0.0008
4939 Cytochrome c2 cycA 0.0008
4964 Cytochrome c2 cycA 0.0008
4979 Cytochrome c2 cycA 0.0008
6673 Cytochrome c2 cycA 0.0008
4984 Neuroglobin NGB 0.0008
4998 Hemoglobin-like protein yjbI yjbI 0.0008
5000 HemO hemO 0.0008
4910 Cytoglobin CYGB 0.0008
4909 CooA protein cooA 0.0008
4981 Iron-starvation protein PigA pigA 0.0008
4907 Cytochrome c-L moxG 0.0008
6865 Cytochrome c-L moxG 0.0008
644 Heme oxygenase 2 HMOX2 0.0008
4982 Heme oxygenase 2 pbsA2 0.0008
4942 Diheme cytochrome c napB napB 0.0008
4935 Cytochrome c-554 cycA1 0.0008
4961 Hemophore HasA hasA 0.0008
4904 Cytochrome c family protein GSU1996 0.0008
4971 Nonaheme cytochrome c hmcA 0.0008
4976 Apocytochrome f petA 0.0008
6407 Apocytochrome f petA 0.0008
4764 Cytochrome P450 165C4 CYP165C4 0.0008
4999 Cytochrome P450 165B3 CYP165B3 0.0008
4960 Putative cytochrome P450-family protein SCO7417 0.0008
4931 Cytochrome P450 167A1 CYP167A1 0.0008
4989 Cytochrome c551 peroxidase ccp 0.0008
5222 Cytochrome c551 peroxidase ccpA 0.0008
4937 Cytochrome oxidase subunit II rcoxA 0.0008
4972 P450cin cinA 0.0008
4903 Methyl-accepting chemotaxis protein Tar4 0.0008
4926 Heme-based aerotactic transducer hemAT hemAT 0.0008
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0008
4922 Cytochrome c, putative SO_4144 0.0008
4993 Hydroxylamine oxidoreductase hao1 0.0008
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0008
3093 Catalase HPII katE 0.0008
4952 Catalase/peroxidase katA 0.0008
1867 Major prion protein PRNP 0.0008
1507 Cytochrome c CYCS 0.0008
500 Monocarboxylate transporter 4 SLC16A3 0.0008
2530 Protein kinase C theta type PRKCQ 0.0008
1025 Aquaporin-1 AQP1 0.0008
866 Large neutral amino acids transporter small subunit 2 SLC7A8 0.0007
822 Aldose reductase AKR1B1 0.0007
6207 30S ribosomal protein S14 rpsN 0.0007
6209 30S ribosomal protein S19 rpsS 0.0007
6712 30S ribosomal protein S19 rpsS 0.0007
6726 30S ribosomal protein S19 rpsS 0.0007
6134 Sodium channel subunit beta-3 SCN3B 0.0007
6133 Sodium channel subunit beta-2 SCN2B 0.0007
6135 Sodium channel subunit beta-4 SCN4B 0.0007
6132 Sodium channel subunit beta-1 SCN1B 0.0007
6129 Carbonic anhydrase-related protein 11 CA11 0.0007
6127 Carbonic anhydrase-related protein CA8 0.0007
6128 Carbonic anhydrase-related protein 10 CA10 0.0007
645 Penicillin-binding protein 1A mrcA 0.0007
5805 Penicillin-binding protein 1A ponA 0.0007
6185 Penicillin-binding protein 1A mrcA 0.0007
6799 Penicillin-binding protein 1A pbpA 0.0007
2511 MAP kinase-activated protein kinase 2 MAPKAPK2 0.0007
125 DNA polymerase beta POLB 0.0007
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0006
6130 Carbonic anhydrase 13 CA13 0.0006
4920 Peroxidase/catalase katG 0.0006
2119 Cytochrome b5 CYB5A 0.0006
4990 PpcA ppcA 0.0006
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0006
3375 Acidic cytochrome c3 Not Available 0.0006
4988 Sulfite oxidase, mitochondrial SUOX 0.0006
2915 Sensor protein fixL fixL 0.0006
4944 Sensor protein fixL fixL 0.0006
4385 Cytochrome c' Not Available 0.0006
4967 Cytochrome c' cycA 0.0006
5038 Cytochrome c' Not Available 0.0006
5223 Cytochrome c' cycP 0.0006
3570 Cytochrome P450 152A1 cypC 0.0006
4813 Heme oxygenase hmuO 0.0006
5769 Heme oxygenase Not Available 0.0006
4289 Cytochrome P450 TT_P0059 0.0006
6262 Cytochrome P450 staP 0.0006
4992 Cytochrome c peroxidase Not Available 0.0006
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.0006
5221 Cytochrome c3, 13 kDa Not Available 0.0006
3152 Cytochrome c'' cycA 0.0006
5220 Split-Soret cytochrome c Ddes_2150 0.0006
3700 Cytochrome c-552 precursor nrfA 0.0006
1721 Glycogen synthase kinase-3 beta GSK3B 0.0005
3411 Cytochrome P450 121 cyp121 0.0005
3670 Soluble cytochrome b562 precursor cybC 0.0005
3291 Cytochrome c-552 cycA 0.0005
4927 Cytochrome c-552 nrfA 0.0005
4938 Cytochrome c-552 cycA 0.0005
4953 Cytochrome c-552 nrfA 0.0005
5217 Cytochrome c-552 cycM 0.0005
2617 Nitric oxide synthase oxygenase nos 0.0005
2701 Nitric oxide synthase oxygenase nos 0.0005
3102 Flavohemoprotein hmp 0.0005
4969 Flavohemoprotein hmp 0.0005
3127 Nitrite reductase nirS 0.0005
3284 Nitrite reductase nirS 0.0005
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0005
2972 6-deoxyerythronolide B hydroxylase eryF 0.0005
4608 Putative cytochrome P450 SCO1207 0.0004
4963 Putative cytochrome P450 SCO2884 0.0004
6254 Putative cytochrome P450 SCO6998 0.0004
3405 Quinohaemoprotein ethanol dehydrogenase type-1 qheDH 0.0004
693 Hemoglobin subunit beta HBB 0.0004
6268 Hydroxyacid oxidase 1 HAO1 0.0004
810 Heme oxygenase 1 HMOX1 0.0004
3391 Heme oxygenase 1 pbsA1 0.0004
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