DT-Web: DB00668

Identification

Name

Epinephrine

Accession Number

DB00668 (APRD00450, EXPT00496)

Type

small molecule

Description

The active sympathomimetic hormone from the adrenal medulla in most species. It stimulates both the alpha- and beta- adrenergic systems, causes systemic vasoconstriction and gastrointestinal relaxation, stimulates the heart, and dilates bronchi and cerebral vessels. It is used in asthma and cardiac failure and to delay absorption of local anesthetics. [PubChem]

Structure

MOL SDF PDB SMILES InChI

Categories ^(*)

Molecular Weight

183.2044

Groups

approved

Monoisotopic Weight

183.089543287

Pharmacology

Indication

Used to treat anaphylaxis and sepsis. Also one of the body's main adrenergic neurotransmitters.

Mechanism of action

Epinephrine works via the stimulation of alpha and beta-1 adrenergic receptors, and a moderate activity at beta-2 adrenergic receptors.

Absorption

Usually this vasodilator effect of the drug on the circulation predominates so that the modest rise in systolic pressure which follows slow injection or absorption is mainly the result of direct cardiac stimulation and increase in cardiac output.

Protein binding

Not Available

Biotransformation

Epinephrine is rapidly inactivated in the body and is degraded by enzymes in the liver and other tissues. The larger portion of injected doses is excreted in the urine as inactivated compounds and the remainder either partly unchanged or conjugated. The drug becomes fixed in the tissues and is inactivated chiefly by enzymatic transformation to metanephrine or normetanephrine either of which is subsequently conjugated and excreted in the urine in the form of sulfates and glucuronides. Either sequence results in the formation of 3-methoxy-4-hydroxy-mandelic acid which also is detectable in the urine. Main metabolic enzymes include MAO and COMT

Route of elimination

Renal

Toxicity

Skin, LD₅₀ = 62 mg/kg (rat)

Affected organisms

Humans and other mammals

Interactions

Drug Interactions

Drug	Mechanism of interaction
Acebutolol	Hypertension, then bradycardia
Alseroxylon	Increased arterial pressure
Amitriptyline	The tricyclic antidepressant, amitriptyline, may increase the sympathomimetic effect of epinephrine.
Amoxapine	The tricyclic antidepressant, amoxapine, increases the sympathomimetic effect of epinephrine.
Atenolol	Hypertension, then bradycardia
Betaxolol	Beta-Blockers such as betaxolol may enhance the vasopressor effect of epinephrine. Monitor for increases in pressor effects of alpha-/beta-agonists if used in patients receiving beta-blocker therapy (including ophthalmic products). Beta1-selective (i.e., "cardioselective") agents may confer a more limited risk if used in low enough doses to allow them to retain their selectivity. The amount of epinephrine used in dental procedures as part of local anesthetic administration is not likely to be of clinical concern. Infiltrating larger volumes of local anesthetics for other surgical procedures (e.g., more than 0.06mg epinephrine) may cause clinically-relevant problems. Patients with allergies that require carrying and periodically using subcutaneous epinephrine (e.g., bee sting kits) should probably avoid the use of beta blockers.
Bevantolol	Hypertension, then bradycardia
Bisoprolol	Hypertension, then bradycardia
Carteolol	Hypertension, then bradycardia
Carvedilol	Hypertension, then bradycardia
Clomipramine	The tricyclic antidepressant, clomipramine, increases the sympathomimetic effect of epinephrine.
Deserpidine	Increased arterial pressure
Desipramine	Trimipramine may increase the vasopressor effect of the direct-acting alpha-/beta-agonist, Epinephrine. Avoid combination if possible. Monitor sympathetic response to therapy if used concomitantly.
Desvenlafaxine	Desvenlafaxine may increase the tachycardic and vasopressor effects of epinephrine. Consider alternate therapy or monitor for increased sympathomimetic effects, such as increased blood pressure, chest pain and headache.
Doxepin	The tricyclic antidepressant, doxepin, increases the sympathomimetic effect of epinephrine.
Entacapone	Entacapone may increase the effect and toxicity of the sympathomimetic, epinephrine.
Ergonovine	Possible marked increase of arterial pressure
Esmolol	Hypertension, then bradycardia
Guanethidine	Epinephrine may decrease the effect of guanethidine.
Imipramine	The tricyclic antidepressant, imipramine, increases the sympathomimetic effect of epinephrine.
Insulin Lispro	Concomitant therapy with sympathomimetic agents may reduce the blood-glucose-lowering effect of insulin lispro.
Isocarboxazid	Increased arterial pressure
Labetalol	Hypertension, then bradycardia
Linezolid	Possible increase of arterial pressure
Lurasidone	Epinephrine increases toxicity (enhance hypotensive effects) of lurasidone by pharmacodynamic synergism.
Methyldopa	Increased arterial pressure
Methylergonovine	Possible marked increase of arterial pressure
Metoprolol	Hypertension, then bradycardia
Midodrine	Increased arterial pressure
Moclobemide	Moclobemide increases the sympathomimetic effect of epinephrine.
Nadolol	Hypertension, then bradycardia
Nortriptyline	The tricyclic antidepressant, nortriptyline, increases the sympathomimetic effect of epinephrine.
Oxprenolol	Hypertension, then bradycardia
Oxytocin	Possible marked increase of arterial pressure
Pargyline	Increased arterial pressure
Penbutolol	Hypertension, then bradycardia
Phenelzine	Increased arterial pressure
Pindolol	Hypertension, then bradycardia
Practolol	Hypertension, then bradycardia
Propranolol	Hypertension, then bradycardia
Protriptyline	The tricyclic antidepressant, protriptyline, increases the sympathomimetic effect of epinephrine.
Rasagiline	Increased arterial pressure
Reserpine	Increased arterial pressure
Sotalol	Hypertension, then bradycardia
Timolol	Hypertension, then bradycardia
Tranylcypromine	Increased arterial pressure
Trimipramine	Trimipramine may increase the vasopressor effect of the direct-acting alpha-/beta-agonist, Epinephrine. Avoid combination if possible. Monitor sympathetic response to therapy if used concomitantly.
Venlafaxine	Venlafaxine may increase the tachycardic and vasopressor effects of epinephrine. Consider alternate therapy or monitor for increased sympathomimetic effects, such as increased blood pressure, chest pain and headache.

Food Interactions

Not Available

Alpha-1A adrenergic receptor
Name	Alpha-1A adrenergic receptor
Gene Name	ADRA1A
Pharmacological action	yes
Actions	agonist
References	Sanbe A, Tanaka Y, Fujiwara Y, Tsumura H, Yamauchi J, Cotecchia S, Koike K, Tsujimoto G, Tanoue A: alpha(1)-Adrenoceptors are required for normal male sexual function. Br J Pharmacol. 2007 Oct;152(3):332-40. Epub 2007 Jul 2. - Pubmed Tomiyama Y, Kobayashi K, Tadachi M, Kobayashi S, Inada Y, Kobayashi M, Yamazaki Y: Expressions and mechanical functions of alpha(1)-adrenoceptor subtypes in hamster ureter. Eur J Pharmacol. 2007 Nov 14;573(1-3):201-5. Epub 2007 Jul 6. - Pubmed Du L, Li M: Modeling the interactions between alpha(1)-adrenergic receptors and their antagonists. Curr Comput Aided Drug Des. 2010 Sep;6(3):165-78. - Pubmed Jensen BC, Swigart PM, Montgomery MD, Simpson PC: Functional alpha-1B adrenergic receptors on human epicardial coronary artery endothelial cells. Naunyn Schmiedebergs Arch Pharmacol. 2010 Dec;382(5-6):475-82. Epub 2010 Sep 22. - Pubmed
DTHybrid score	0.7052
Alpha-1B adrenergic receptor
Name	Alpha-1B adrenergic receptor
Gene Name	ADRA1B
Pharmacological action	yes
Actions	agonist
References	Cotecchia S: The alpha1-adrenergic receptors: diversity of signaling networks and regulation. J Recept Signal Transduct Res. 2010 Dec;30(6):410-9. Epub 2010 Oct 18. - Pubmed Shieh JP, Chu CC, Wang JJ, Lin MT: Epinephrine, phenylephrine, and methoxamine induce infiltrative anesthesia via alpha1-adrenoceptors in rats. Acta Pharmacol Sin. 2009 Sep;30(9):1227-36. - Pubmed Du L, Li M: Modeling the interactions between alpha(1)-adrenergic receptors and their antagonists. Curr Comput Aided Drug Des. 2010 Sep;6(3):165-78. - Pubmed Jensen BC, Swigart PM, Montgomery MD, Simpson PC: Functional alpha-1B adrenergic receptors on human epicardial coronary artery endothelial cells. Naunyn Schmiedebergs Arch Pharmacol. 2010 Dec;382(5-6):475-82. Epub 2010 Sep 22. - Pubmed
DTHybrid score	0.4931
Beta-1 adrenergic receptor
Name	Beta-1 adrenergic receptor
Gene Name	ADRB1
Pharmacological action	yes
Actions	agonist
References	Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed Ozakca I, Arioglu E, Guner S, Altan VM, Ozcelikay AT: Role of Beta-3-Adrenoceptor in Catecholamine-Induced Relaxations in Gastric Fundus from Control and Diabetic Rats. Pharmacology. 2007 Jul 6;80(4):227-238. - Pubmed Leineweber K, Bogedain P, Wolf C, Wagner S, Weber M, Jakob HG, Heusch G, Philipp T, Brodde OE: In patients chronically treated with metoprolol, the demand of inotropic catecholamine support after coronary artery bypass grafting is determined by the Arg389Gly-beta 1-adrenoceptor polymorphism. Naunyn Schmiedebergs Arch Pharmacol. 2007 Jul;375(5):303-9. Epub 2007 Jun 1. - Pubmed
DTHybrid score	0.8071
Beta-2 adrenergic receptor
Name	Beta-2 adrenergic receptor
Gene Name	ADRB2
Pharmacological action	yes
Actions	agonist
References	Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed Ozakca I, Arioglu E, Guner S, Altan VM, Ozcelikay AT: Role of Beta-3-Adrenoceptor in Catecholamine-Induced Relaxations in Gastric Fundus from Control and Diabetic Rats. Pharmacology. 2007 Jul 6;80(4):227-238. - Pubmed Prenner L, Sieben A, Zeller K, Weiser D, Haberlein H: Reduction of high-affinity beta2-adrenergic receptor binding by hyperforin and hyperoside on rat C6 glioblastoma cells measured by fluorescence correlation spectroscopy. Biochemistry. 2007 May 1;46(17):5106-13. Epub 2007 Apr 7. - Pubmed Lucin KM, Sanders VM, Jones TB, Malarkey WB, Popovich PG: Impaired antibody synthesis after spinal cord injury is level dependent and is due to sympathetic nervous system dysregulation. Exp Neurol. 2007 Sep;207(1):75-84. Epub 2007 Jun 2. - Pubmed
DTHybrid score	0.8203
Alpha-2A adrenergic receptor
Name	Alpha-2A adrenergic receptor
Gene Name	ADRA2A
Pharmacological action	yes
Actions	agonist
References	Nyronen T, Pihlavisto M, Peltonen JM, Hoffren AM, Varis M, Salminen T, Wurster S, Marjamaki A, Kanerva L, Katainen E, Laaksonen L, Savola JM, Scheinin M, Johnson MS: Molecular mechanism for agonist-promoted alpha(2A)-adrenoceptor activation by norepinephrine and epinephrine. Mol Pharmacol. 2001 May;59(5):1343-54. - Pubmed MacLennan SJ, Reynen PH, Martin RS, Eglen RM, Martin GR: Characterization of human recombinant alpha(2A)-adrenoceptors expressed in Chinese hamster lung cells using extracellular acidification rate changes. Br J Pharmacol. 2000 Apr;129(7):1333-8. - Pubmed Hieble JP, Hehr A, Li YO, Ruffolo RR Jr: Molecular basis for the stereoselective interactions of catecholamines with alpha-adrenoceptors. Proc West Pharmacol Soc. 1998;41:225-8. - Pubmed Nash DT: Alpha-adrenergic blockers: mechanism of action, blood pressure control, and effects of lipoprotein metabolism. Clin Cardiol. 1990 Nov;13(11):764-72. - Pubmed Giovannoni MP, Ghelardini C, Vergelli C, Dal Piaz V: Alpha2-agonists as analgesic agents. Med Res Rev. 2009 Mar;29(2):339-68. - Pubmed Gilsbach R, Hein L: Presynaptic metabotropic receptors for acetylcholine and adrenaline/noradrenaline. Handb Exp Pharmacol. 2008;(184):261-88. - Pubmed
DTHybrid score	0.5534
Alpha-2B adrenergic receptor
Name	Alpha-2B adrenergic receptor
Gene Name	ADRA2B
Pharmacological action	yes
Actions	agonist
References	Gobbi M, Frittoli E, Mennini T: The modulation of [3H]noradrenaline and [3H]serotonin release from rat brain synaptosomes is not mediated by the alpha 2B-adrenoceptor subtype. Naunyn Schmiedebergs Arch Pharmacol. 1990 Oct;342(4):382-6. - Pubmed Vizi ES, Katona I, Freund TF: Evidence for presynaptic cannabinoid CB(1) receptor-mediated inhibition of noradrenaline release in the guinea pig lung. Eur J Pharmacol. 2001 Nov 16;431(2):237-44. - Pubmed Rudling JE, Richardson J, Evans PD: A comparison of agonist-specific coupling of cloned human alpha(2)-adrenoceptor subtypes. Br J Pharmacol. 2000 Nov;131(5):933-41. - Pubmed Nash DT: Alpha-adrenergic blockers: mechanism of action, blood pressure control, and effects of lipoprotein metabolism. Clin Cardiol. 1990 Nov;13(11):764-72. - Pubmed Gilsbach R, Hein L: Presynaptic metabotropic receptors for acetylcholine and adrenaline/noradrenaline. Handb Exp Pharmacol. 2008;(184):261-88. - Pubmed
DTHybrid score	0.3354
Alpha-1D adrenergic receptor
Name	Alpha-1D adrenergic receptor
Gene Name	ADRA1D
Pharmacological action	unknown
Actions	antagonist
References	Cotecchia S: The alpha1-adrenergic receptors: diversity of signaling networks and regulation. J Recept Signal Transduct Res. 2010 Dec;30(6):410-9. Epub 2010 Oct 18. - Pubmed Shieh JP, Chu CC, Wang JJ, Lin MT: Epinephrine, phenylephrine, and methoxamine induce infiltrative anesthesia via alpha1-adrenoceptors in rats. Acta Pharmacol Sin. 2009 Sep;30(9):1227-36. - Pubmed Du L, Li M: Modeling the interactions between alpha(1)-adrenergic receptors and their antagonists. Curr Comput Aided Drug Des. 2010 Sep;6(3):165-78. - Pubmed Jensen BC, Swigart PM, Montgomery MD, Simpson PC: Functional alpha-1B adrenergic receptors on human epicardial coronary artery endothelial cells. Naunyn Schmiedebergs Arch Pharmacol. 2010 Dec;382(5-6):475-82. Epub 2010 Sep 22. - Pubmed
DTHybrid score	0.361
Phenylalanine-4-hydroxylase
Name	Phenylalanine-4-hydroxylase
Gene Name	PAH
Pharmacological action	no
Actions	antagonist
References	Erlandsen H, Flatmark T, Stevens RC, Hough E: Crystallographic analysis of the human phenylalanine hydroxylase catalytic domain with bound catechol inhibitors at 2.0 A resolution. Biochemistry. 1998 Nov 10;37(45):15638-46. - Pubmed
DTHybrid score	0.6549

Cytochrome P450 1A2
Name	Cytochrome P450 1A2
Gene Name	CYP1A2
Actions	inhibitor
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.4817
Cytochrome P450 2C9
Name	Cytochrome P450 2C9
Gene Name	CYP2C9
Actions	inhibitor
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.3639
Cytochrome P450 3A4
Name	Cytochrome P450 3A4
Gene Name	CYP3A4
Actions	inhibitor
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.6071

Solute carrier family 22 member 2
Name	Solute carrier family 22 member 2
Gene Name	SLC22A2
Actions	substrate,inhibitor
References	Urakami Y, Okuda M, Masuda S, Akazawa M, Saito H, Inui K: Distinct characteristics of organic cation transporters, OCT1 and OCT2, in the basolateral membrane of renal tubules. Pharm Res. 2001 Nov;18(11):1528-34. - Pubmed Grundemann D, Koster S, Kiefer N, Breidert T, Engelhardt M, Spitzenberger F, Obermuller N, Schomig E: Transport of monoamine transmitters by the organic cation transporter type 2, OCT2. J Biol Chem. 1998 Nov 20;273(47):30915-20. - Pubmed
DTHybrid score	0.3185
Solute carrier family 22 member 1
Name	Solute carrier family 22 member 1
Gene Name	SLC22A1
Actions	substrate,inhibitor
References	Urakami Y, Okuda M, Masuda S, Akazawa M, Saito H, Inui K: Distinct characteristics of organic cation transporters, OCT1 and OCT2, in the basolateral membrane of renal tubules. Pharm Res. 2001 Nov;18(11):1528-34. - Pubmed Breidert T, Spitzenberger F, Grundemann D, Schomig E: Catecholamine transport by the organic cation transporter type 1 (OCT1). Br J Pharmacol. 1998 Sep;125(1):218-24. - Pubmed
DTHybrid score	0.3772
Organic cation/carnitine transporter 2
Name	Organic cation/carnitine transporter 2
Gene Name	SLC22A5
Actions	inhibitor
References	Ohashi R, Tamai I, Nezu Ji J, Nikaido H, Hashimoto N, Oku A, Sai Y, Shimane M, Tsuji A: Molecular and physiological evidence for multifunctionality of carnitine/organic cation transporter OCTN2. Mol Pharmacol. 2001 Feb;59(2):358-66. - Pubmed
DTHybrid score	0.2904

Id	Partner name	Gene Name	Score
3109	Phenylalanine-4-hydroxylase	phhA	0.6549
4119	Cytochrome P450 2D6	CYP2D6	0.4763
1588	Multidrug resistance protein 1	ABCB1	0.3083
378	Alpha-2C adrenergic receptor	ADRA2C	0.2736
6016	Cytochrome P450 2C19	CYP2C19	0.2583
1517	Beta-3 adrenergic receptor	ADRB3	0.1952
502	5-hydroxytryptamine 2A receptor	HTR2A	0.195
320	5-hydroxytryptamine 1A receptor	HTR1A	0.1894
23	D(1A) dopamine receptor	DRD1	0.1869
831	D(2) dopamine receptor	DRD2	0.1825
4118	Cytochrome P450 3A5	CYP3A5	0.1729
540	Sodium-dependent noradrenaline transporter	SLC6A2	0.1693
4924	Cytochrome P450 2C8	CYP2C8	0.1544
492	Histamine H1 receptor	HRH1	0.1412
6147	Solute carrier family 22 member 3	SLC22A3	0.1375
590	5-hydroxytryptamine 2C receptor	HTR2C	0.1307
6013	Cytochrome P450 2E1	CYP2E1	0.1261
6030	Cytochrome P450 2B6	CYP2B6	0.124
6107	Cytochrome P450 3A7	CYP3A7	0.1235
6024	Cytochrome P450 1A1	CYP1A1	0.1223
885	5-hydroxytryptamine 1B receptor	HTR1B	0.1202
5666	Parathyroid hormone	PTH	0.1158
1181	Alpha-1-acid glycoprotein 1	ORM1	0.112
432	D(4) dopamine receptor	DRD4	0.1072
833	Organic cation/carnitine transporter 1	SLC22A4	0.1032
638	D(3) dopamine receptor	DRD3	0.0995
713	Sodium-dependent dopamine transporter	SLC6A3	0.0988
101	Potassium voltage-gated channel subfamily H member 2	KCNH2	0.0983
725	5-hydroxytryptamine 1D receptor	HTR1D	0.0982
824	Sodium-dependent serotonin transporter	SLC6A4	0.0971
163	D(1B) dopamine receptor	DRD5	0.0936
587	Serum albumin	ALB	0.0935
617	Muscarinic acetylcholine receptor M2	CHRM2	0.0843
51	Muscarinic acetylcholine receptor M3	CHRM3	0.0826
103	Muscarinic acetylcholine receptor M1	CHRM1	0.0819
3941	Amine oxidase [flavin-containing] A	MAOA	0.0817
5718	Cytochrome P450 2A6	CYP2A6	0.0799
676	Tyrosine 3-monooxygenase	TH	0.0797
274	Muscarinic acetylcholine receptor M5	CHRM5	0.0725
1729	Solute carrier family 22 member 6	SLC22A6	0.0719
450	Muscarinic acetylcholine receptor M4	CHRM4	0.0705
3923	Cholinesterase	BCHE	0.0684
20	Prostaglandin G/H synthase 1	PTGS1	0.0682
131	Synaptic vesicular amine transporter	SLC18A2	0.0676
1732	ATP-binding cassette sub-family G member 2	ABCG2	0.0671
6142	Solute carrier family 22 member 8	SLC22A8	0.067
7	Nitric oxide synthase, inducible	NOS2	0.0628
1735	Canalicular multispecific organic anion transporter 1	ABCC2	0.0612
436	5-hydroxytryptamine 2B receptor	HTR2B	0.0609
1539	Oligopeptide transporter, small intestine isoform	SLC15A1	0.0571
716	5-hydroxytryptamine 7 receptor	HTR7	0.0539
341	5-hydroxytryptamine 3 receptor	HTR3A	0.0535
291	Nitric-oxide synthase, endothelial	NOS3	0.0509
290	Prostaglandin G/H synthase 2	PTGS2	0.0507
862	Multidrug resistance-associated protein 1	ABCC1	0.0487
6164	POU domain, class 5, transcription factor 1	POU5F1	0.0466
1256	5-hydroxytryptamine 6 receptor	HTR6	0.0457
1490	Solute carrier organic anion transporter family member 1B1	SLCO1B1	0.0455
514	Potassium voltage-gated channel subfamily H member 6	KCNH6	0.0454
772	Potassium voltage-gated channel subfamily H member 7	KCNH7	0.0454
6139	Solute carrier organic anion transporter family member 1A2	SLCO1A2	0.0445
6106	Cytochrome P450 2C18	CYP2C18	0.0441
3939	Amine oxidase [flavin-containing] B	MAOB	0.0426
1974	Oligopeptide transporter, kidney isoform	SLC15A2	0.0412
124	Histamine H2 receptor	HRH2	0.0409
3876	Aromatic-L-amino-acid decarboxylase	DDC	0.0392
3810	Catechol O-methyltransferase	COMT	0.039
477	DNA topoisomerase 4 subunit A	parC	0.038
886	DNA topoisomerase 4 subunit A	parC	0.038
6226	DNA topoisomerase 4 subunit A	parC	0.038
404	DNA gyrase subunit A	gyrA	0.0374
6224	DNA gyrase subunit A	gyrA	0.0374
220	Sodium channel protein type 5 subunit alpha	SCN5A	0.0374
6151	Monocarboxylate transporter 10	SLC16A10	0.0358
2675	Pteridine reductase 1	PTR1	0.035
3811	Cytochrome P450 19A1	CYP19A1	0.0349
776	Bile salt export pump	ABCB11	0.0343
134	Tryptophan 5-hydroxylase 1	TPH1	0.0336
817	DNA topoisomerase 2-alpha	TOP2A	0.033
1024	Solute carrier family 22 member 11	SLC22A11	0.033
6178	UDP-glucuronosyltransferase 2B7	UGT2B7	0.0328
6143	Solute carrier family 22 member 7	SLC22A7	0.0325
1632	Solute carrier organic anion transporter family member 2B1	SLCO2B1	0.032
465	Calmodulin	CALM1	0.0315
872	Gamma-aminobutyric-acid receptor subunit alpha-1	GABRA1	0.0313
6070	Nischarin	NISCH	0.0305
1898	Cytochrome P450 1B1	CYP1B1	0.0305
813	Neuronal acetylcholine receptor subunit alpha-2	CHRNA2	0.0305
76	Nitric-oxide synthase, brain	NOS1	0.0301
2300	Lysozyme	E	0.03
3633	Lysozyme	R	0.03
5597	Lysozyme	17	0.03
2360	Dihydroneopterin aldolase	folB	0.0293
474	Acetylcholinesterase	ACHE	0.029
6022	UDP-glucuronosyltransferase 1-1	UGT1A1	0.0277
136	Estrogen receptor	ESR1	0.0274
709	ATP-sensitive inward rectifier potassium channel 1	KCNJ1	0.0271
528	5-hydroxytryptamine 1E receptor	HTR1E	0.0264
36	Insulin receptor	INSR	0.0258
4115	Voltage-dependent L-type calcium channel subunit alpha-1D	CACNA1D	0.0255
31	Phenylalanyl-tRNA synthetase, mitochondrial	FARS2	0.0251
42	Phenylalanyl-tRNA synthetase alpha chain	FARSA	0.0251
6602	Phenylalanyl-tRNA synthetase alpha chain	pheS	0.0251
618	Phenylalanyl-tRNA synthetase beta chain	FARSB	0.0251
6603	Phenylalanyl-tRNA synthetase beta chain	pheT	0.0251
478	Voltage-dependent L-type calcium channel subunit alpha-1C	CACNA1C	0.0249
6010	Thiamine transporter 1	SLC19A2	0.0248
6138	Multidrug resistance protein 3	ABCB4	0.0245
1636	Trace amine-associated receptor 1	TAAR1	0.0243
4110	Voltage-dependent L-type calcium channel subunit beta-2	CACNB2	0.0228
2164	Multidrug resistance-associated protein 4	ABCC4	0.0227
6040	6-phosphogluconate dehydrogenase, decarboxylating	PGD	0.0222
175	Thiamin pyrophosphokinase 1	TPK1	0.0222
6154	Multidrug and toxin extrusion protein 1	SLC47A1	0.0221
6018	UDP-glucuronosyltransferase 1-9	UGT1A9	0.0213
6020	Aldehyde oxidase	AOX1	0.0211
731	HIV-1 protease	HIV-1 protease	0.0208
4111	Voltage-dependent L-type calcium channel subunit alpha-1S	CACNA1S	0.0207
805	Cytochrome P450 11B1, mitochondrial	CYP11B1	0.0205
777	Tumor necrosis factor	TNF	0.0197
6025	UDP-glucuronosyltransferase 1-4	UGT1A4	0.0195
3947	Xanthine dehydrogenase/oxidase	XDH	0.0191
6137	Multidrug resistance-associated protein 6	ABCC6	0.0188
1820	Beta-nerve growth factor	NGF	0.0186
871	Glucocorticoid receptor	NR3C1	0.0186
159	Penicillin-binding protein 2B	penA	0.0182
6121	Penicillin-binding protein 2B	penA	0.0182
866	Large neutral amino acids transporter small subunit 2	SLC7A8	0.018
6101	Dimethylaniline monooxygenase [N-oxide-forming] 3	FMO3	0.0179
1709	Canalicular multispecific organic anion transporter 2	ABCC3	0.0179
763	Tyrosine aminotransferase	TAT	0.0178
5493	Tyrosine aminotransferase	Not Available	0.0178
4097	Neuronal acetylcholine receptor subunit alpha-9	CHRNA9	0.0176
4113	Voltage-dependent L-type calcium channel subunit alpha-1F	CACNA1F	0.0175
6098	Potassium voltage-gated channel subfamily D member 2	KCND2	0.0174
6099	Potassium voltage-gated channel subfamily D member 3	KCND3	0.0174
738	Monocarboxylate transporter 1	SLC16A1	0.0173
1757	Myeloperoxidase	MPO	0.0166
6148	Multidrug resistance-associated protein 7	ABCC10	0.0166
6017	Cholesterol side-chain cleavage enzyme, mitochondrial	CYP11A1	0.0164
696	Kappa-type opioid receptor	OPRK1	0.0163
6157	Solute carrier organic anion transporter family member 1B3	SLCO1B3	0.0162
233	Potassium channel subfamily K member 2	KCNK2	0.0155
467	Delta-type opioid receptor	OPRD1	0.0155
164	Histamine H4 receptor	HRH4	0.0155
4114	Voltage-dependent L-type calcium channel subunit beta-3	CACNB3	0.0153
4112	Voltage-dependent L-type calcium channel subunit beta-4	CACNB4	0.0153
4146	Phosphatidylinositol 3-kinase regulatory subunit gamma	PIK3R3	0.0151
4145	Phosphatidylinositol 3-kinase regulatory subunit beta	PIK3R2	0.0151
6160	Solute carrier organic anion transporter family member 3A1	SLCO3A1	0.0151
847	Mu-type opioid receptor	OPRM1	0.0148
734	D1 dopamine receptor-interacting protein calcyon	CALY	0.0146
706	Glutamate [NMDA] receptor subunit 3A	GRIN3A	0.0145
6023	Cytochrome P450 11B2, mitochondrial	CYP11B2	0.0144
6176	UDP-glucuronosyltransferase 1-3	UGT1A3	0.0142
198	Sodium channel protein type 10 subunit alpha	SCN10A	0.0142
6432	Transporter	snf	0.0142
4773	Deoxycytidine kinase	DCK	0.0141
4203	Histamine N-methyltransferase	HNMT	0.014
580	Gamma-aminobutyric-acid receptor subunit alpha-3	GABRA3	0.0139
158	Sodium channel protein type 1 subunit alpha	SCN1A	0.0139
333	Voltage-dependent L-type calcium channel subunit beta-1	CACNB1	0.0139
423	Gamma-aminobutyric-acid receptor subunit alpha-2	GABRA2	0.0139
4209	ATP-sensitive inward rectifier potassium channel 8	KCNJ8	0.0138
281	5'-AMP-activated protein kinase subunit beta-1	PRKAB1	0.0137
147	Aldehyde dehydrogenase, mitochondrial	ALDH2	0.0134
748	5'-AMP-activated protein kinase catalytic subunit alpha-1	PRKAA1	0.013
122	P2Y purinoceptor 12	P2RY12	0.0128
624	Guanidinoacetate N-methyltransferase	GAMT	0.0128
2472	Voltage-gated potassium channel	kcsA	0.0128
6366	Voltage-gated potassium channel	kcsA	0.0128
260	Cytochrome P450 51	ERG11	0.0127
761	Cytochrome P450 51	ERG11	0.0127
3163	Cytochrome P450 51	cyp51	0.0127
523	Gamma-aminobutyric-acid receptor subunit alpha-5	GABRA5	0.0126
1281	Phosphatidylinositol 3-kinase regulatory subunit alpha	PIK3R1	0.0125
672	Prostaglandin F2-alpha receptor	PTGFR	0.0125
4292	Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase	lpxA	0.0124
6136	Multidrug resistance-associated protein 5	ABCC5	0.0123
633	Penicillin-binding proteins 1A/1B	pbpA	0.0123
3076	Antigen 85-C	fbpC	0.0122
4120	NADPH--cytochrome P450 reductase	POR	0.0121
1656	CYP2B protein	CYP2B	0.0117
891	Dihydropteroate synthase	folP	0.0116
5359	Dihydropteroate synthase	folP	0.0116
7175	Dihydropteroate synthase	sulI	0.0116
6014	Cytochrome P450 2A13	CYP2A13	0.0114
385	Potassium-transporting ATPase alpha chain 1	ATP4A	0.0113
485	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	PDE3A	0.0112
762	Voltage-dependent calcium channel subunit alpha-2/delta-1	CACNA2D1	0.011
380	Cytochrome P450 17A1	CYP17A1	0.0109
6104	Dimethylaniline monooxygenase [N-oxide-forming] 1	FMO1	0.0109
756	Sex hormone-binding globulin	SHBG	0.0109
1341	Histamine H3 receptor	HRH3	0.0109
6158	Solute carrier organic anion transporter family member 1C1	SLCO1C1	0.0108
468	Cytochrome P450 4A11	CYP4A11	0.0108
787	Vitamin K epoxide reductase complex subunit 1	VKORC1	0.0106
3970	Voltage-dependent N-type calcium channel subunit alpha-1B	CACNA1B	0.0105
1064	DNA (cytosine-5)-methyltransferase 1	DNMT1	0.0105
6141	Sodium/bile acid cotransporter	SLC10A1	0.0104
70	Type-1 angiotensin II receptor	AGTR1	0.0104
1830	5'-nucleotidase	NT5E	0.01
869	Estrogen receptor beta	ESR2	0.01
5126	Arginase	rocF	0.01
1360	Sphingomyelin phosphodiesterase	SMPD1	0.01
614	Progesterone receptor	PGR	0.01
230	ATP-binding cassette transporter sub-family C member 8	ABCC8	0.0099
115	Penicillin-binding protein 2	mrdA	0.0099
6069	Penicillin-binding protein 2	mrdA	0.0099
6118	Penicillin-binding protein 2	penA	0.0099
6187	Penicillin-binding protein 2	pbpA	0.0099
6686	Penicillin-binding protein 2	pbp2	0.0099
6939	Penicillin-binding protein 2	mrdA	0.0099
7163	Penicillin-binding protein 2	pbpA	0.0099
6031	Cytochrome P450 3A43	CYP3A43	0.0099
964	Voltage-dependent T-type calcium channel subunit alpha-1H	CACNA1H	0.0099
1374	Natriuretic peptides B	NPPB	0.0099
1827	Gap junction alpha-1 protein	GJA1	0.0098
1908	Vascular cell adhesion protein 1	VCAM1	0.0098
183	Vascular endothelial growth factor A	VEGFA	0.0098
509	Thymidine kinase	TK	0.0097
570	Thymidine kinase	TK	0.0097
2559	Thymidine kinase	TK	0.0097
3430	Thymidine kinase	tdk	0.0097
3518	Thymidine kinase	TK	0.0097
5301	Thymidine kinase	tdk	0.0097
5771	Thymidine kinase	ORF36	0.0097
7009	Thymidine kinase	ORF36	0.0097
958	Insulin-like growth factor 1 receptor	IGF1R	0.0097
6152	Solute carrier organic anion transporter family member 2A1	SLCO2A1	0.0095
462	Intermediate conductance calcium-activated potassium channel protein 4	KCNN4	0.0095
530	Gamma-aminobutyric-acid receptor subunit alpha-4	GABRA4	0.0094
6153	Solute carrier organic anion transporter family member 4A1	SLCO4A1	0.0094
737	Mineralocorticoid receptor	NR3C2	0.0094
841	Gamma-aminobutyric-acid receptor subunit alpha-6	GABRA6	0.0093
6847	Lactase-phlorizin hydrolase	LCT	0.0093
1618	High affinity nerve growth factor receptor	NTRK1	0.0093
677	Choline-phosphate cytidylyltransferase A	PCYT1A	0.0092
204	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE5A	0.0091
571	Melatonin receptor type 1A	MTNR1A	0.009
362	Melatonin receptor type 1B	MTNR1B	0.009
3426	Glutamine synthetase	glnA	0.009
3987	Glutamine synthetase	GLUL	0.009
976	Platelet glycoprotein IX	GP9	0.009
1680	Solute carrier family 2, facilitated glucose transporter member 1	SLC2A1	0.0089
818	50S ribosomal protein L10	rplJ	0.0089
16	Adenosine A1 receptor	ADORA1	0.0088
1176	Mitogen-activated protein kinase 1	MAPK1	0.0087
6220	Aryl hydrocarbon receptor	AHR	0.0087
694	Matrix protein 2	M	0.0086
2222	Equilibrative nucleoside transporter 1	SLC29A1	0.0086
338	DNA polymerase	UL30	0.0086
379	DNA polymerase	UL54	0.0086
697	DNA polymerase	ORF28	0.0086
2482	DNA polymerase	43	0.0086
4104	DNA polymerase	BALF5	0.0086
3611	Cytidine deaminase	cdd	0.0085
3707	Cytidine deaminase	cdd	0.0085
4211	Cytidine deaminase	CDA	0.0085
15	Voltage-dependent T-type calcium channel subunit alpha-1I	CACNA1I	0.0085
535	Voltage-dependent T-type calcium channel subunit alpha-1G	CACNA1G	0.0084
153	Dopamine beta-hydroxylase	DBH	0.0083
1	Peptidoglycan synthetase ftsI	ftsI	0.0083
4155	Peptidoglycan synthetase ftsI	ftsI	0.0083
1284	Nuclear receptor subfamily 1 group I member 2	NR1I2	0.0082
194	NADH dehydrogenase [ubiquinone] 1 subunit C2	NDUFC2	0.0082
527	Prostacyclin receptor	PTGIR	0.0082
504	Mast/stem cell growth factor receptor	KIT	0.0081
213	Amiloride-sensitive sodium channel subunit alpha	SCNN1A	0.0081
550	Amiloride-sensitive sodium channel subunit delta	SCNN1D	0.0081
27	Amiloride-sensitive sodium channel subunit beta	SCNN1B	0.0081
552	Amiloride-sensitive sodium channel subunit gamma	SCNN1G	0.0081
125	DNA polymerase beta	POLB	0.0081
4100	Gamma-aminobutyric-acid receptor subunit beta-2	GABRB2	0.0081
232	Corticosteroid-binding globulin	SERPINA6	0.008
645	Penicillin-binding protein 1A	mrcA	0.0079
5805	Penicillin-binding protein 1A	ponA	0.0079
6185	Penicillin-binding protein 1A	mrcA	0.0079
6799	Penicillin-binding protein 1A	pbpA	0.0079
4099	Gamma-aminobutyric-acid receptor subunit beta-3	GABRB3	0.0079
6086	Gamma-aminobutyric acid receptor subunit gamma-2	GABRG2	0.0079
146	Androgen receptor	AR	0.0078
867	Penicillin-binding protein 3	pbpC	0.0077
6119	Penicillin-binding protein 3	pbp3	0.0077
7154	Penicillin-binding protein 3	pbp3	0.0077
7157	Penicillin-binding protein 3	LMHCC_2184	0.0077
7162	Penicillin-binding protein 3	pbpB	0.0077
7172	Penicillin-binding protein 3	pbp3	0.0077
3704	Spermidine/putrescine-binding periplasmic protein precursor	potD	0.0077
401	Glutamate [NMDA] receptor subunit zeta-1	GRIN1	0.0077
4095	Neuronal acetylcholine receptor subunit alpha-7	CHRNA7	0.0077
947	Neuronal acetylcholine receptor subunit alpha-4	CHRNA4	0.0077
4604	Liver carboxylesterase 1	CES1	0.0075
1178	Adenosine A2a receptor	ADORA2A	0.0074
811	Translocator protein	TSPO	0.0074
6146	High affinity copper uptake protein 1	SLC31A1	0.0073
238	Peroxisome proliferator-activated receptor gamma	PPARG	0.0073
4116	Dihydropteroate synthetase	Not Available	0.0072
6087	Gamma-aminobutyric acid receptor subunit gamma-1	GABRG1	0.0072
6093	Gamma-aminobutyric acid receptor subunit delta	GABRD	0.0072
6089	Gamma-aminobutyric acid receptor subunit epsilon	GABRE	0.0072
80	Peroxisome proliferator-activated receptor alpha	PPARA	0.0072
228	Beta platelet-derived growth factor receptor	PDGFRB	0.0071
6047	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	PDE1A	0.0071
6171	Solute carrier family 28 member 3	SLC28A3	0.007
4098	Gamma-aminobutyric-acid receptor subunit beta-1	GABRB1	0.007
49	Endothelin B receptor	EDNRB	0.0069
844	Epidermal growth factor receptor	EGFR	0.0069
357	Carbonic anhydrase 2	CA2	0.0069
6088	Gamma-aminobutyric acid receptor subunit gamma-3	GABRG3	0.0069
6090	Gamma-aminobutyric acid receptor subunit pi	GABRP	0.0069
6092	Gamma-aminobutyric acid receptor subunit rho-2	GABRR2	0.0069
6115	Gamma-aminobutyric acid receptor subunit rho-3	GABRR3	0.0069
6182	Cytochrome P450 2J2	CYP2J2	0.0068
389	Amiloride-sensitive cation channel 2, neuronal	ACCN2	0.0068
142	Gamma-aminobutyric-acid receptor subunit rho-1	GABRR1	0.0068
2157	NAD(P)H dehydrogenase [quinone] 1	NQO1	0.0067
781	ATP-sensitive inward rectifier potassium channel 11	KCNJ11	0.0067
5692	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	PDE1B	0.0067
3560	Gentamicin 3'-acetyltransferase	aacC1	0.0067
592	Carbonic anhydrase 4	CA4	0.0067
295	Carbonic anhydrase 1	CA1	0.0067
6079	Neuronal acetylcholine receptor subunit alpha-3	CHRNA3	0.0066
749	Amiloride-sensitive cation channel 1, neuronal	ACCN1	0.0066
6177	UDP-glucuronosyltransferase 1-10	UGT1A10	0.0065
578	Endothelin-1 receptor	EDNRA	0.0065
858	Potassium voltage-gated channel subfamily A member 1	KCNA1	0.0065
1759	85 kDa calcium-independent phospholipase A2	PLA2G6	0.0064
1770	Phospholipase C	PLCL1	0.0064
2841	Phospholipase C	plc	0.0064
723	Cytosolic phospholipase A2	PLA2G4A	0.0063
192	Creatine kinase, ubiquitous mitochondrial	CKMT1A	0.0063
456	Creatine kinase, sarcomeric mitochondrial	CKMT2	0.0063
904	Glutathione S-transferase P	GSTP1	0.0063
92	Creatine kinase B-type	CKB	0.0063
414	Sodium- and chloride-dependent creatine transporter 1	SLC6A8	0.0063
6068	Guanylate cyclase soluble subunit alpha-2	GUCY1A2	0.0063
407	Vascular endothelial growth factor receptor 2	KDR	0.0063
133	Dihydropterate synthase	sulI	0.0063
161	Tubulin beta chain	TUBB	0.0062
312	Tubulin beta chain	TUB2	0.0062
1629	Transcription factor AP-1	JUN	0.0061
1995	Sodium channel protein type 9 subunit alpha	SCN9A	0.0061
908	Glutathione S-transferase theta-1	GSTT1	0.0061
6100	BDNF/NT-3 growth factors receptor	NTRK2	0.006
464	Glutamate [NMDA] receptor subunit epsilon-2	GRIN2B	0.006
982	Cocaine- and amphetamine-regulated transcript protein	CARTPT	0.006
4160	Voltage-dependent calcium channel subunit alpha-2/delta-2	CACNA2D2	0.006
17	Proto-oncogene tyrosine-protein kinase ABL1	ABL1	0.0059
6102	Arylamine N-acetyltransferase 2	NAT2	0.0059
332	Beta-lactamase	blaZ	0.0059
2478	Beta-lactamase	ampC	0.0059
2613	Beta-lactamase	ampC	0.0059
2635	Beta-lactamase	ampC	0.0059
2700	Beta-lactamase	penP	0.0059
5445	Beta-lactamase	blaB	0.0059
6019	Beta-lactamase	SHV-7	0.0059
6701	Beta-lactamase	cphA	0.0059
6091	Gamma-aminobutyric acid receptor subunit theta	GABRQ	0.0059
4148	Serine/threonine-protein kinase mTOR	MTOR	0.0059
387	Amiloride-sensitive amine oxidase [copper-containing]	ABP1	0.0059
7187	Amiloride-sensitive amine oxidase [copper-containing]	ABP1	0.0059
3610	Thioredoxin reductase 1, cytoplasmic	TXNRD1	0.0059
631	3-hydroxy-3-methylglutaryl-coenzyme A reductase	HMGCR	0.0059
3387	3-hydroxy-3-methylglutaryl-coenzyme A reductase	mvaA	0.0059
950	Alpha platelet-derived growth factor receptor	PDGFRA	0.0059
6149	Solute carrier family 22 member 10	SLC22A10	0.0058
751	Potassium channel subfamily K member 6	KCNK6	0.0058
6165	Copper-transporting ATPase 1	ATP7A	0.0058
6163	Copper-transporting ATPase 2	ATP7B	0.0058
6067	Penicillin binding protein 2a	mecA	0.0058
6111	DNA polymerase epsilon subunit 4	POLE4	0.0058
827	Sodium/hydrogen exchanger 1	SLC9A1	0.0058
6112	DNA polymerase epsilon subunit 3	POLE3	0.0058
6108	Ribonucleoside-diphosphate reductase subunit M2 B	RRM2B	0.0058
6110	DNA polymerase epsilon subunit 2	POLE2	0.0058
6109	DNA polymerase epsilon catalytic subunit A	POLE	0.0058
275	Arachidonate 5-lipoxygenase	ALOX5	0.0057
2449	Tubulin alpha-3 chain	TUBA1A	0.0057
6180	UDP-glucuronosyltransferase 2B4	UGT2B4	0.0057
788	Creatine kinase M-type	CKM	0.0057
94	5-hydroxytryptamine 4 receptor	HTR4	0.0057
778	Cysteinyl leukotriene receptor 1	CYSLTR1	0.0057
5682	Ribonuclease pancreatic	RNASE1	0.0056
427	Substance-P receptor	TACR1	0.0056
3929	Phosphoethanolamine/phosphocholine phosphatase	PHOSPHO1	0.0056
3933	Choline/ethanolaminephosphotransferase	CEPT1	0.0056
549	Choline-phosphate cytidylyltransferase B	PCYT1B	0.0056
3926	Choline transporter-like protein 2	SLC44A2	0.0056
861	Choline kinase alpha	CHKA	0.0056
1686	Choline transporter-like protein 1	SLC44A1	0.0056
769	High-affinity choline transporter 1	SLC5A7	0.0056
3927	Choline transporter-like protein 3	SLC44A3	0.0056
3925	Choline transporter-like protein 4	SLC44A4	0.0056
264	Choline/ethanolamine kinase [Includes: Choline kinase beta	CHKB	0.0056
700	Choline dehydrogenase, mitochondrial	CHDH	0.0056
576	Choline O-acetyltransferase	CHAT	0.0056
3922	Phospholipase D2	PLD2	0.0056
3924	Phospholipase D1	PLD1	0.0056
4122	Histone deacetylase 2	HDAC2	0.0056
6155	ATP-binding cassette transporter sub-family C member 11	ABCC11	0.0055
1086	Potassium voltage-gated channel subfamily KQT member 2	KCNQ2	0.0055
6218	Pannexin-1	PANX1	0.0055
896	Glutathione S-transferase Mu 1	GSTM1	0.0054
6085	Fatty acid-binding protein, intestinal	FABP2	0.0054
458	Neuronal acetylcholine receptor subunit alpha-10	CHRNA10	0.0054
4152	Superoxide dismutase [Cu-Zn]	SOD1	0.0054
620	Bifunctional dihydrofolate reductase-thymidylate synthase	Not Available	0.0054
172	Potassium channel subfamily K member 1	KCNK1	0.0053
5998	Toll-like receptor 8	TLR8	0.0053
6078	Neuronal acetylcholine receptor subunit beta-4	CHRNB4	0.0053
6080	Neuronal acetylcholine receptor subunit alpha-5	CHRNA5	0.0053
948	Neuronal acetylcholine receptor subunit beta-2	CHRNB2	0.0053
6082	Neuronal acetylcholine receptor subunit beta-3	CHRNB3	0.0053
365	Dihydrofolate reductase	DHFR	0.0052
2381	Dihydrofolate reductase	DFR1	0.0052
2833	Dihydrofolate reductase	Not Available	0.0052
2931	Dihydrofolate reductase	folA	0.0052
3544	Dihydrofolate reductase	folA	0.0052
3682	Dihydrofolate reductase	folA	0.0052
6642	Dihydrofolate reductase	folA	0.0052
6756	Dihydrofolate reductase	dfrA	0.0052
565	Extracellular calcium-sensing receptor	CASR	0.0052
712	Tubulin alpha chain	TUB1	0.0052
29	Tubulin beta-1 chain	TUBB1	0.0052
259	Microsomal triglyceride transfer protein large subunit	MTTP	0.0052
860	Nicotinamide N-methyltransferase	NNMT	0.0051
583	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	QPRT	0.0051
2442	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	nadC	0.0051
2459	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	nadC	0.0051
699	Nicotinic acid receptor 1	GPR109A	0.0051
928	Nicotinic acid receptor 2	GPR109B	0.0051
284	DNA-directed RNA polymerase beta chain	rpoB	0.0051
5773	DNA-directed RNA polymerase beta chain	rpoB	0.0051
5626	Nucleoside diphosphate kinase B	NME2	0.0051
73	Prostaglandin E2 receptor, EP1 subtype	PTGER1	0.0051
4177	Proto-oncogene tyrosine-protein kinase receptor ret	RET	0.005
6167	Organic solute transporter subunit beta	OSTB	0.005
613	Atrial natriuretic peptide receptor A	NPR1	0.005
6166	Organic solute transporter subunit alpha	OSTA	0.005
4218	Ribonucleoside-diphosphate reductase M2 subunit	RRM2	0.005
837	Glutamate [NMDA] receptor subunit epsilon-1	GRIN2A	0.0049
273	Apoptosis regulator Bcl-2	BCL2	0.0049
6081	Neuronal acetylcholine receptor subunit alpha-6	CHRNA6	0.0049
6859	Protein S100-A4	S100A4	0.0048
26	Vascular endothelial growth factor receptor 3	FLT4	0.0048
482	Glycine receptor subunit alpha-1	GLRA1	0.0048
1864	RET proto-oncogene	RET	0.0047
621	Periplasmic [Fe] hydrogenase 1	Not Available	0.0047
1950	Epithelial discoidin domain-containing receptor 1	DDR1	0.0047
6170	ATP-binding cassette sub-family A member 3	ABCA3	0.0047
6094	BCR/ABL fusion protein isoform X9	BCR/ABL fusion	0.0047
511	5-hydroxytryptamine 1F receptor	HTR1F	0.0047
3804	Sodium channel protein type 4 subunit alpha	SCN4A	0.0047
814	Ryanodine receptor 1	RYR1	0.0046
606	Cytochrome P450 27, mitochondrial	CYP27A1	0.0046
6140	Ileal sodium/bile acid cotransporter	SLC10A2	0.0046
541	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	PDE4B	0.0046
243	Ribosyldihydronicotinamide dehydrogenase [quinone]	NQO2	0.0046
68	Cannabinoid receptor 1	CNR1	0.0046
32	Vascular endothelial growth factor receptor 1	FLT1	0.0046
173	Toll-like receptor 7	TLR7	0.0046
4237	50S ribosomal protein L22	rplV	0.0046
992	Protein tyrosine kinase 2 beta	PTK2B	0.0045
303	Diamine acetyltransferase 2	SAT2	0.0045
623	Spermine oxidase	SMOX	0.0045
1317	Spermine synthase	SMS	0.0045
6181	UDP-glucuronosyltransferase 1-8	UGT1A8	0.0045
6043	Putative G-protein coupled receptor 44	GPR44	0.0044
918	Glutamate receptor, ionotropic kainate 2	GRIK2	0.0044
1010	Cytochrome P450 51A1	CYP51A1	0.0044
342	P protein [Includes: DNA-directed DNA polymerase	P	0.0044
612	P protein [Includes: DNA-directed DNA polymerase	P	0.0044
130	Prostacyclin synthase	PTGIS	0.0044
1275	Estrogen sulfotransferase	SULT1E1	0.0044
603	DNA polymerase alpha catalytic subunit	POLA1	0.0043
3755	Nucleoside-specific channel-forming protein tsx precursor	tsx	0.0043
1787	Nuclear factor NF-kappa-B p105 subunit	NFKB1	0.0043
780	Retinoic acid receptor RXR-gamma	RXRG	0.0043
952	Dipeptidyl peptidase 4	DPP4	0.0043
558	Solute carrier family 12 member 1	SLC12A1	0.0042
714	Glutathione reductase, mitochondrial	GSR	0.0042
1971	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	PDE4A	0.0042
373	Transthyretin	TTR	0.0042
1648	Elastin	ELN	0.0041
424	Dihydroorotate dehydrogenase, mitochondrial	DHODH	0.0041
360	Ribonucleoside-diphosphate reductase large subunit	RRM1	0.0041
5878	Alpha-7 nicotinic cholinergic receptor subunit	CHRFAM7A	0.0041
856	Vitamin D3 receptor	VDR	0.0041
459	Retinoic acid receptor RXR-alpha	RXRA	0.0041
3997	Cytochrome P450 24A1, mitochondrial	CYP24A1	0.0041
921	Glutamate receptor 2	GRIA2	0.0041
5294	Nucleoside diphosphate kinase A	NME1	0.0041
951	Macrophage colony-stimulating factor 1 receptor	CSF1R	0.004
123	Diamine acetyltransferase 1	SAT1	0.004
1561	Troponin C, slow skeletal and cardiac muscles	TNNC1	0.004
6032	PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE)	fas	0.004
54	Prothrombin	F2	0.004
200	Carnitine O-palmitoyltransferase 2, mitochondrial	CPT2	0.0039
451	Carnitine O-palmitoyltransferase I, liver isoform	CPT1A	0.0039
1541	Metalloproteinase	mmp20	0.0039
215	Sodium channel protein type 11 subunit alpha	SCN11A	0.0039
88	Retinoic acid receptor RXR-beta	RXRB	0.0039
1129	C-C chemokine receptor type 5	CCR5	0.0039
698	B-Raf proto-oncogene serine/threonine-protein kinase	BRAF	0.0038
605	Fumarate reductase flavoprotein subunit	frdA	0.0038
2709	Fumarate reductase flavoprotein subunit	SO_0970	0.0038
3673	Fumarate reductase flavoprotein subunit	fccA	0.0038
4912	Fumarate reductase flavoprotein subunit	ifcA	0.0038
6549	Fumarate reductase flavoprotein subunit	frdA	0.0038
6126	Carbonic anhydrase 7	CA7	0.0038
24	Thymidylate synthase	TMP1	0.0038
359	Thymidylate synthase	TYMS	0.0038
2626	Thymidylate synthase	thyA	0.0038
2729	Thymidylate synthase	thyA	0.0038
5352	Thymidylate synthase	THYA	0.0038
6045	Voltage-dependent calcium channel subunit alpha-2/delta-3	CACNA2D3	0.0037
702	UMP-CMP kinase	CMPK1	0.0037
705	Glutamate receptor 1	GRIA1	0.0037
6044	Serum paraoxonase/lactonase 3	PON3	0.0037
33	Cystine/glutamate transporter	SLC7A11	0.0036
6211	Tubulin epsilon chain	TUBE1	0.0036
6212	Tubulin gamma-1 chain	TUBG1	0.0036
6210	Tubulin delta chain	TUBD1	0.0036
1074	Urokinase-type plasminogen activator	PLAU	0.0036
4192	DNA topoisomerase 2-beta	TOP2B	0.0035
1502	Peroxisome proliferator-activated receptor delta	PPARD	0.0035
185	Vasopressin V1a receptor	AVPR1A	0.0035
6206	DNA-directed RNA polymerase subunit beta'	rpoC	0.0035
117	Sterol O-acyltransferase 1	SOAT1	0.0035
4217	Telomerase reverse transcriptase	TERT	0.0035
939	50S ribosomal protein L3	rplC	0.0035
322	Vasopressin V2 receptor	AVPR2	0.0034
489	Monocarboxylate transporter 2	SLC16A7	0.0034
2499	Tubulin beta-2C chain	TUBB2C	0.0034
596	3-oxo-5-alpha-steroid 4-dehydrogenase 1	SRD5A1	0.0033
6002	Prostaglandin E2 receptor EP4 subtype	PTGER4	0.0033
277	Purine nucleoside phosphorylase	PNP	0.0033
2870	Purine nucleoside phosphorylase	punA	0.0033
2945	Purine nucleoside phosphorylase	punA	0.0033
4659	Purine nucleoside phosphorylase	TM_1596	0.0033
4825	Purine nucleoside phosphorylase	TTHA1435	0.0033
499	Arginine decarboxylase	ADC	0.0033
2251	Thymidylate kinase	tmk	0.0033
2254	Thymidylate kinase	DTYMK	0.0033
3522	Thymidylate kinase	tmk	0.0033
3478	Glucose-1-phosphate thymidylyltransferase	rmlA	0.0032
4277	Glucose-1-phosphate thymidylyltransferase	rmlA	0.0032
610	Calcium-activated potassium channel subunit alpha 1	KCNMA1	0.0032
109	Mitochondrial carnitine/acylcarnitine carrier protein CACL	SLC25A29	0.0032
636	Mitochondrial carnitine/acylcarnitine carrier protein	SLC25A20	0.0032
500	Monocarboxylate transporter 4	SLC16A3	0.0032
140	30S ribosomal protein S9	rpsI	0.0031
6719	30S ribosomal protein S9	rpsI	0.0031
6725	30S ribosomal protein S9	rpsI	0.0031
276	Sodium- and chloride-dependent GABA transporter 1	SLC6A1	0.0031
2257	Uridine phosphorylase	udp	0.0031
5132	Uridine phosphorylase	udp	0.0031
449	Ornithine decarboxylase	ODC1	0.0031
4131	Prostaglandin E2 receptor, EP3 subtype	PTGER3	0.0031
1227	Cytochrome b	MT-CYB	0.0031
6386	Cytochrome b	petB	0.0031
6937	Cytochrome b	MT-CYB	0.0031
674	Dihydroorotate dehydrogenase homolog, mitochondrial	PFF0160c	0.0031
577	Argininosuccinate lyase	ASL	0.0031
406	Prostaglandin E2 receptor, EP2 subtype	PTGER2	0.0031
834	Arginase-2, mitochondrial	ARG2	0.0031
2578	Tubulin beta-3 chain	TUBB3	0.003
2285	Streptogramin A acetyltransferase	vatD	0.003
518	Peroxidase/catalase T	katG	0.003
4228	Keratin, type II cytoskeletal 7	KRT7	0.003
6168	Solute carrier family 22 member 16	SLC22A16	0.003
150	Cationic amino acid transporter 3	SLC7A3	0.003
235	High-affinity cationic amino acid transporter 1	SLC7A1	0.003
58	Cationic amino acid transporter 4	SLC7A4	0.003
750	Voltage-dependent calcium channel gamma-1 subunit	CACNG1	0.0029
4238	50S ribosomal protein L4	rplD	0.0029
5578	50S ribosomal protein L4	rplD	0.0029
6173	50S ribosomal protein L4	rplD	0.0029
6219	50S ribosomal protein L4	rplD	0.0029
1039	Histone deacetylase 9	HDAC9	0.0029
3957	Adenosine deaminase	ADA	0.0029
512	DNA-directed RNA polymerase alpha chain	rpoA	0.0029
5772	DNA-directed RNA polymerase alpha chain	rpoA	0.0029
239	Coagulation factor X	F10	0.0028
740	Argininosuccinate synthase	ASS1	0.0028
865	Argininosuccinate synthase	ASS1	0.0028
2680	Argininosuccinate synthase	argG	0.0028
3194	Argininosuccinate synthase	argG	0.0028
1200	AMBP protein	AMBP	0.0028
3866	Serum amyloid A protein	SAA1	0.0028
1932	Apolipoprotein E	APOE	0.0028
543	Penicillin-binding protein 1B	mrcB	0.0028
6186	Penicillin-binding protein 1B	ponB	0.0028
6822	Penicillin-binding protein 1b	pbp1b	0.0028
6844	Penicillin-binding protein 1b	pbp1b	0.0028
823	Fibroblast growth factor receptor 2	FGFR2	0.0027
650	Aldo-keto reductase family 1 member C3	AKR1C3	0.0027
1144	Hepatocyte growth factor receptor	MET	0.0027
66	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II	HSD3B2	0.0027
4173	Tyrosine-protein kinase JAK2	JAK2	0.0027
2159	Quinone oxidoreductase	CRYZ	0.0027
563	Thyroid peroxidase	TPO	0.0027
392	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	CACNA1A	0.0027
3849	Insulin-like growth factor-binding protein 7	IGFBP7	0.0027
2009	Protein NOV homolog	NOV	0.0027
3847	Neuroendocrine convertase 2	PCSK2	0.0027
1949	Carboxypeptidase E	CPE	0.0027
3850	Synaptotagmin-like protein 4	SYTL4	0.0027
3848	Neuroendocrine convertase 1	PCSK1	0.0027
3846	Retinoblastoma-associated protein	RB1	0.0027
412	Peroxisomal carnitine O-octanoyltransferase	CROT	0.0027
2320	Thymidine kinase, cytosolic	TK1	0.0027
1050	Bile salt sulfotransferase	SULT2A1	0.0027
551	Carnitine O-acetyltransferase	CRAT	0.0027
567	Receptor tyrosine-protein kinase erbB-2	ERBB2	0.0026
790	DNA polymerase subunit alpha B	POLA2	0.0026
241	Calcium-transporting ATPase type 2C member 1	ATP2C1	0.0026
634	Squalene monooxygenase	SQLE	0.0025
7196	Squalene monooxygenase	ERG1	0.0025
630	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial	ACADSB	0.0025
5880	Thrombopoietin receptor	MPL	0.0025
182	2-oxoglutarate dehydrogenase E1 component, mitochondrial	OGDH	0.0025
390	Adenosine A3 receptor	ADORA3	0.0025
1457	Long-chain-fatty-acid--CoA ligase 4	ACSL4	0.0025
768	FK506-binding protein 1A	FKBP1A	0.0025
537	ATP synthase delta chain, mitochondrial	ATP5D	0.0025
6038	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6H	0.0024
1192	Sulfotransferase 1A1	SULT1A1	0.0024
544	Potassium voltage-gated channel subfamily E member 1	KCNE1	0.0024
1483	Membrane copper amine oxidase	AOC3	0.0024
6039	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	PDE11A	0.0024
3639	Thymidine phosphorylase	deoA	0.0024
3936	Thymidine phosphorylase	TYMP	0.0024
5852	Type-2 angiotensin II receptor	AGTR2	0.0024
515	26S proteasome non-ATPase regulatory subunit 1	PSMD1	0.0024
522	26S proteasome non-ATPase regulatory subunit 2	PSMD2	0.0024
559	NADH-ubiquinone oxidoreductase chain 1	MT-ND1	0.0023
208	DNA-directed RNA polymerase beta' chain	rpoC	0.0023
5774	DNA-directed RNA polymerase beta' chain	rpoC	0.0023
642	3-oxo-5-alpha-steroid 4-dehydrogenase 2	SRD5A2	0.0023
40	RAF proto-oncogene serine/threonine-protein kinase	RAF1	0.0023
6037	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6G	0.0023
1302	Dihydropyrimidine dehydrogenase [NADP+]	DPYD	0.0023
581	Cytochrome P450 2R1	CYP2R1	0.0023
280	4-aminobutyrate aminotransferase, mitochondrial	ABAT	0.0022
990	Dual specificity mitogen-activated protein kinase kinase 1	MAP2K1	0.0022
6179	UDP-glucuronosyltransferase 2B17	UGT2B17	0.0022
170	Succinate semialdehyde dehydrogenase, mitochondrial	ALDH5A1	0.0022
2155	Insulin-degrading enzyme	IDE	0.0022
2232	Interleukin-5	IL5	0.0022
2981	Phospholipase A2, membrane associated	PLA2G2A	0.0021
298	Renin	REN	0.0021
1593	Mucin-2	MUC2	0.0021
6506	Stathmin-4	STMN4	0.0021
1638	Solute carrier family 2, facilitated glucose transporter member 2	SLC2A2	0.0021
2091	Endoplasmin	HSP90B1	0.0021
2184	Cystic fibrosis transmembrane conductance regulator	CFTR	0.0021
1244	Low-density lipoprotein receptor-related protein 2	LRP2	0.0021
741	Potassium voltage-gated channel subfamily KQT member 1	KCNQ1	0.0021
2539	Tubulin alpha-1 chain	TUBA4A	0.0021
1852	Microtubule-associated protein 2	MAP2	0.0021
2461	D-alanyl-D-alanine carboxypeptidase	Not Available	0.002
5756	D-alanyl-D-alanine carboxypeptidase	dac	0.002
6150	Solute carrier organic anion transporter family member 4C1	SLCO4C1	0.002
6161	Probable low affinity copper uptake protein 2	SLC31A2	0.002
6103	Arylamine N-acetyltransferase 1	NAT1	0.002
4199	Sphingosine 1-phosphate receptor Edg-8	S1PR5	0.002
3932	Glutathione S-transferase A2	GSTA2	0.0019
368	Enoyl-[acyl-carrier-protein] reductase [NADH]	inhA	0.0019
3228	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0019
3678	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0019
6856	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0019
4311	tRNA	TRDMT1	0.0019
4325	tRNA	trmD	0.0019
4328	tRNA	trmD	0.0019
4103	Proteasome subunit beta type 2	PSMB2	0.0018
4102	Proteasome subunit beta type 5	PSMB5	0.0018
4101	Proteasome subunit beta type 1	PSMB1	0.0018
6766	O-GlcNAcase BT_4395	BT_4395	0.0018
3854	Basic fibroblast growth factor receptor 1	FGFR1	0.0018
1968	ATP-sensitive inward rectifier potassium channel 12	KCNJ12	0.0018
683	Potassium transporter	GK0582	0.0018
1123	Eosinophil cationic protein	RNASE3	0.0018
67	Prolyl 4-hydroxylase subunit alpha-1	P4HA1	0.0017
564	Cellular retinoic acid-binding protein 1	CRABP1	0.0017
165	FL cytokine receptor	FLT3	0.0017
137	FolC bifunctional protein [Includes: Folylpolyglutamate synthase	folC	0.0017
106	Cannabinoid receptor 2	CNR2	0.0017
6174	50S ribosomal protein L32	rpmF	0.0017
859	Cellular retinoic acid-binding protein 2	CRABP2	0.0017
6046	Voltage-gated calcium channel beta 1 subunit splice variant CavB1d	CACNB1	0.0017
251	Alcohol dehydrogenase 1A	ADH1A	0.0017
1196	Complement decay-accelerating factor	CD55	0.0017
3809	Estrogen-related receptor gamma	ESRRG	0.0017
1243	Cathepsin D	CTSD	0.0016
5251	Carbonyl reductase [NADPH] 1	CBR1	0.0016
102	DNA topoisomerase I, mitochondrial	TOP1MT	0.0016
936	Ephrin type-A receptor 2	EPHA2	0.0016
3830	Calreticulin	CALR	0.0016
820	Glycine receptor subunit alpha-2	GLRA2	0.0016
268	Adenosine A2b receptor	ADORA2B	0.0015
3233	Bile acid receptor	NR1H4	0.0015
2853	14 kDa fatty acid-binding protein	Not Available	0.0015
3856	Fibroblast growth factor receptor 3	FGFR3	0.0015
3937	Fatty-acid amide hydrolase	FAAH	0.0015
139	Aldo-keto reductase family 1 member C1	AKR1C1	0.0015
5787	Angiopoietin-1 receptor	TEK	0.0015
1714	Mitogen-activated protein kinase 3	MAPK3	0.0015
6034	Hydroxyindole O-methyltransferase	ASMT	0.0015
3844	HLA class II histocompatibility antigen, DQ(6) alpha chain	HLA-DQA2	0.0015
6035	Nuclear receptor ROR-beta	RORB	0.0015
6036	Eosinophil peroxidase	EPX	0.0015
1939	Heat shock protein HSP 90-alpha	HSP90AA1	0.0015
444	Alcohol dehydrogenase 1B	ADH1B	0.0015
3802	Sodium channel protein type 2 subunit alpha	SCN2A	0.0015
2808	Chloramphenicol acetyltransferase 3	cat3	0.0014
84	Nuclear receptor 0B1	NR0B1	0.0014
162	Retinoic acid receptor gamma-1	RARG	0.0014
4226	Uridine phosphorylase 2	UPP2	0.0014
2180	3-phosphoinositide-dependent protein kinase 1	PDPK1	0.0014
3917	Methylenetetrahydrofolate reductase	MTHFR	0.0013
1353	DNA topoisomerase 1	TOP1	0.0013
3552	DNA topoisomerase 1	topA	0.0013
2417	Chloramphenicol acetyltransferase	cat	0.0013
3278	Chloramphenicol acetyltransferase	cat	0.0013
3808	Dihydropteroate synthase 2	folP2	0.0013
3601	Dihydropteroate synthase 1	folP1	0.0013
3807	Dihydropteroate synthase 1	folP1	0.0013
2810	Dr hemagglutinin structural subunit	draA	0.0013
2718	Chloramphenicol 3-O phosphotransferase	Not Available	0.0013
2236	Casein kinase II subunit alpha	CSNK2A1	0.0013
6123	Carbonic anhydrase 5A, mitochondrial	CA5A	0.0013
765	Indoleamine 2,3-dioxygenase	IDO1	0.0013
6933	Calcium-activated potassium channel subunit beta-4	KCNMB4	0.0013
6931	Calcium-activated potassium channel subunit beta-1	KCNMB1	0.0013
6932	Calcium-activated potassium channel subunit beta-3	KCNMB3	0.0013
4225	Uridine phosphorylase 1	UPP1	0.0013
6934	Small conductance calcium-activated potassium channel protein 1	KCNN1	0.0013
6935	Small conductance calcium-activated potassium channel protein 2	KCNN2	0.0013
6936	Small conductance calcium-activated potassium channel protein 3	KCNN3	0.0013
517	Alcohol dehydrogenase 1C	ADH1C	0.0013
6116	Gastric triacylglycerol lipase	LIPF	0.0012
5934	Cytochrome P450 26A1	CYP26A1	0.0012
3806	cGMP-dependent 3',5'-cyclic phosphodiesterase	PDE2A	0.0012
3823	Cytokine receptor common gamma chain	IL2RG	0.0012
85	Growth hormone receptor	GHR	0.0012
2107	Microtubule-associated protein 1A	MAP1A	0.0012
413	Amidophosphoribosyltransferase	PPAT	0.0012
2515	Amidophosphoribosyltransferase	purF	0.0012
3714	Amidophosphoribosyltransferase	purF	0.0012
5924	Microtubule-associated protein 4	MAP4	0.0012
5923	Microtubule-associated protein tau	MAPT	0.0012
3587	Gastrotropin	FABP6	0.0012
1295	Fatty acid synthase	FASN	0.0012
1992	Vitamin D-binding protein	GC	0.0012
319	Opioid receptor, sigma 1	OPRS1	0.0012
933	Proto-oncogene tyrosine-protein kinase Src	SRC	0.0011
935	Proto-oncogene tyrosine-protein kinase Yes	YES1	0.0011
1063	Signal transducer and activator of transcription 5B	STAT5B	0.0011
5463	Calcium-activated potassium channel subunit beta 2	KCNMB2	0.0011
2450	Tyrosine-protein kinase ITK/TSK	ITK	0.0011
754	Pancreatic triacylglycerol lipase	PNLIP	0.0011
1630	Integrin beta-2	ITGB2	0.0011
2183	Fatty acid-binding protein, adipocyte	FABP4	0.0011
591	Glutamate [NMDA] receptor subunit 3B	GRIN3B	0.0011
2178	Metabotropic glutamate receptor 5	GRM5	0.0011
724	Interleukin-2 receptor alpha chain	IL2RA	0.0011
717	Interleukin-2 receptor subunit beta	IL2RB	0.0011
469	Annexin A1	ANXA1	0.0011
6033	High affinity interleukin-8 receptor A	CXCR1	0.001
1810	Protein S100-A1	S100A1	0.001
6097	Protein S100-A2	S100A2	0.001
493	25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	CYP27B1	0.001
695	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	PDE10A	0.001
934	Proto-oncogene tyrosine-protein kinase Fyn	FYN	0.001
439	Glutamate [NMDA] receptor subunit epsilon-4	GRIN2D	0.001
5300	Antigen peptide transporter 1	TAP1	0.001
4041	Microsomal glutathione S-transferase 2	MGST2	0.001
6824	Tyrosine-protein kinase Lyn	LYN	0.001
4162	Potassium voltage-gated channel subfamily KQT member 3	KCNQ3	0.001
174	Sigma 1-type opioid receptor	SIGMAR1	0.001
2268	Cholesterol oxidase	choB	0.0009
2822	Cholesterol oxidase	choA	0.0009
6048	Troponin C, skeletal muscle	TNNC2	0.0009
937	Proto-oncogene tyrosine-protein kinase LCK	LCK	0.0009
484	Tyrosine-protein kinase ABL2	ABL2	0.0009
719	Retinoic acid receptor responder protein 1	RARRES1	0.0009
229	Retinoic acid receptor beta	RARB	0.0009
770	Retinoic acid-induced protein 3	GPRC5A	0.0009
6105	3-oxo-5-beta-steroid 4-dehydrogenase	AKR1D1	0.0009
3086	Plasmepsin-2	Not Available	0.0009
730	Retinoic acid receptor alpha	RARA	0.0009
1048	Protein S100-A13	S100A13	0.0009
2226	Protein S100-A12	S100A12	0.0009
806	Sodium/potassium-transporting ATPase alpha-1 chain	ATP1A1	0.0009
6131	Carbonic anhydrase 14	CA14	0.0009
2283	Steroid Delta-isomerase	ksi	0.0009
2920	Steroid Delta-isomerase	ksi	0.0009
6169	ATP-binding cassette sub-family A member 5	ABCA5	0.0009
2132	Protein S100-B	S100B	0.0009
382	Glutamate receptor, ionotropic kainate 1	GRIK1	0.0008
3961	G protein-activated inward rectifier potassium channel 4	KCNJ5	0.0008
3404	Exotoxin A	eta	0.0008
572	Integrin alpha-L	ITGAL	0.0008
22	30S ribosomal protein S4	rpsD	0.0008
6714	30S ribosomal protein S4	rpsD	0.0008
3868	Calcineurin subunit B isoform 2	PPP3R2	0.0008
421	Calcium signal-modulating cyclophilin ligand	CAMLG	0.0008
6122	Carbonic anhydrase 3	CA3	0.0008
5798	Mitogen-activated protein kinase 11	MAPK11	0.0008
2325	Sulfotransferase family cytosolic 2B member 1	SULT2B1	0.0008
569	Retinal dehydrogenase 2	ALDH1A2	0.0008
267	Plasminogen activator inhibitor 1	SERPINE1	0.0008
760	Fibroblast growth factor 1	FGF1	0.0008
1867	Major prion protein	PRNP	0.0008
4948	Cytochrome c-553	Not Available	0.0008
4923	Cytochrome c3	DvMF_2499	0.0008
4945	Cytochrome c3	Not Available	0.0008
4949	Cytochrome c3	DVU_3171	0.0008
4968	Cytochrome c3	cytc3	0.0008
4997	Cytochrome c3	SO_2727	0.0008
5219	Cytochrome c3	cyd	0.0008
4902	Nine-heme cytochrome c	Ddes_2038	0.0008
3189	High-molecular-weight cytochrome c	hmcA	0.0008
4031	Glutathione S-transferase A1	GSTA1	0.0008
1649	Small inducible cytokine A2	CCL2	0.0008
611	Retinal dehydrogenase 1	ALDH1A1	0.0008
1025	Aquaporin-1	AQP1	0.0008
1768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit	GNG2	0.0008
1268	Neuropeptide S receptor	NPSR1	0.0008
1571	G protein-activated inward rectifier potassium channel 1	KCNJ3	0.0008
1581	G protein-activated inward rectifier potassium channel 2	KCNJ6	0.0008
5766	NAD-dependent deacetylase sirtuin-5	SIRT5	0.0008
400	Coagulation factor IX	F9	0.0008
5461	Coagulation factor IX	F9	0.0008
6893	Calcium/calmodulin-dependent protein kinase type II gamma chain	CAMK2G	0.0007
2298	Cytochrome P450-cam	camC	0.0007
473	L-lactate dehydrogenase A chain	LDHA	0.0007
461	Glycine receptor subunit alpha-3	GLRA3	0.0007
6221	Steroid hormone receptor ERR1	ESRRA	0.0007
521	ATP-binding cassette transporter sub-family C member 9	ABCC9	0.0007
217	Estradiol 17-beta-dehydrogenase 1	HSD17B1	0.0007
822	Aldose reductase	AKR1B1	0.0007
2112	Toll-like receptor 9	TLR9	0.0007
4081	Vitamin K epoxide reductase complex subunit 1-like protein 1	VKORC1L1	0.0007
604	Vitamin K-dependent protein Z	PROZ	0.0007
6228	Nuclear receptor coactivator 1	NCOA1	0.0007
6207	30S ribosomal protein S14	rpsN	0.0007
6209	30S ribosomal protein S19	rpsS	0.0007
6712	30S ribosomal protein S19	rpsS	0.0007
6726	30S ribosomal protein S19	rpsS	0.0007
6241	Nuclear receptor coactivator 2	NCOA2	0.0007
6073	Potassium channel subfamily K member 9	KCNK9	0.0007
6072	Potassium channel subfamily K member 3	KCNK3	0.0007
2290	ADP-ribosyl cyclase 2	BST1	0.0007
226	Gonadotropin-releasing hormone receptor	GNRHR	0.0007
4386	Hemoglobin-like protein HbN	glbN	0.0007
132	ATP-binding cassette sub-family A member 1	ABCA1	0.0007
2599	Tyrosine-protein kinase HCK	HCK	0.0007
1524	Peptidyl-prolyl cis-trans isomerase A	PPIA	0.0006
6700	Peptidyl-prolyl cis-trans isomerase A	ppiA	0.0006
144	Hemoglobin subunit alpha	HBA1	0.0006
1245	Vitamin K-dependent protein S	PROS1	0.0006
422	Vitamin K-dependent protein C	PROC	0.0006
364	Corticosteroid 11-beta-dehydrogenase isozyme 1	HSD11B1	0.0006
3221	Cytochrome c4	cc4	0.0006
890	Niemann-Pick C1-like protein 1	NPC1L1	0.0006
3126	Poly [ADP-ribose] polymerase 1	PARP1	0.0006
1291	cAMP response element-binding protein	CREB1	0.0006
448	Vitamin K-dependent gamma-carboxylase	GGCX	0.0006
1569	G1/S-specific cyclin-D1	CCND1	0.0006
1525	Heparin-binding growth factor 2	FGF2	0.0006
2021	Thrombomodulin	THBD	0.0006
5221	Cytochrome c3, 13 kDa	Not Available	0.0006
3152	Cytochrome c''	cycA	0.0006
5220	Split-Soret cytochrome c	Ddes_2150	0.0006
3700	Cytochrome c-552 precursor	nrfA	0.0006
4210	Toll-like receptor 4	TLR4	0.0005
1760	Aminopeptidase N	ANPEP	0.0005
6843	Aminopeptidase N	pepN	0.0005
1262	Corticotropin-lipotropin	POMC	0.0005
1507	Cytochrome c	CYCS	0.0005
2207	Rhodopsin	RHO	0.0005
244	Angiotensin-converting enzyme	ACE	0.0005
798	Osteocalcin	BGLAP	0.0005
3127	Nitrite reductase	nirS	0.0005
3284	Nitrite reductase	nirS	0.0005
369	Coagulation factor VII	F7	0.0005
3913	Glutamic acid decarboxylase	GAD65	0.0005
505	Glutamate [NMDA] receptor subunit epsilon-3	GRIN2C	0.0004
2038	Inhibitor of nuclear factor kappa-B kinase subunit beta	IKBKB	0.0004
476	RAC-alpha serine/threonine-protein kinase	AKT1	0.0004
3405	Quinohaemoprotein ethanol dehydrogenase type-1	qheDH	0.0004
6042	Prostaglandin reductase 2	PTGR2	0.0004
2216	Fibroblast growth factor receptor 4	FGFR4	0.0004
735	Alanine aminotransferase 1	GPT	0.0004
3904	Alanine aminotransferase 2	GPT2	0.0004
1792	Tissue-type plasminogen activator	PLAT	0.0004
594	Thyroxine-binding globulin	SERPINA7	0.0004
758	Thyroid hormone receptor alpha	THRA	0.0003
2240	Cell division protein kinase 2	CDK2	0.0003
199	Monocarboxylate transporter 8	SLC16A2	0.0003
1313	Lactoylglutathione lyase	GLO1	0.0003
245	Large neutral amino acids transporter small subunit 1	SLC7A5	0.0003
838	Inosine-5'-monophosphate dehydrogenase 1	IMPDH1	0.0003
796	Inosine-5'-monophosphate dehydrogenase 2	IMPDH2	0.0003
346	Thyroid hormone receptor beta-1	THRB	0.0003
4954	Soluble cytochrome b558	Not Available	0.0003
4916	Cyanoglobin	glbN	0.0003
4934	Cytochrome c-551	nirM	0.0003
5218	Cytochrome c-551	nirM	0.0003
4947	Bacterial hemoglobin	vhb	0.0003
4915	Cytochrome c-550	psbV	0.0003
4959	Cytochrome c-550	psbV	0.0003
5216	Cytochrome c-550	psbV	0.0003
4925	Cytochrome c-type protein SHP	shp	0.0003
4905	Cytochrome c2	Not Available	0.0003
4939	Cytochrome c2	cycA	0.0003
4964	Cytochrome c2	cycA	0.0003
4979	Cytochrome c2	cycA	0.0003
6673	Cytochrome c2	cycA	0.0003
4943	Cytochrome c6	petJ	0.0003
4998	Hemoglobin-like protein yjbI	yjbI	0.0003
4984	Neuroglobin	NGB	0.0003
4936	Cytochrome c2 iso-2	Not Available	0.0003
4975	Cytochrome c-556	RPA3973	0.0003
4994	Hemoglobin-like protein HbO	glbO	0.0003
5000	HemO	hemO	0.0003
4910	Cytoglobin	CYGB	0.0003
4981	Iron-starvation protein PigA	pigA	0.0003
4909	CooA protein	cooA	0.0003
3116	Bacterioferritin	bfr	0.0003
4906	Bacterioferritin	bfr	0.0003
4965	Bacterioferritin	bfr	0.0003
4935	Cytochrome c-554	cycA1	0.0003
4907	Cytochrome c-L	moxG	0.0003
6865	Cytochrome c-L	moxG	0.0003
4971	Nonaheme cytochrome c	hmcA	0.0003
4904	Cytochrome c family protein	GSU1996	0.0003
4942	Diheme cytochrome c napB	napB	0.0003
644	Heme oxygenase 2	HMOX2	0.0003
4982	Heme oxygenase 2	pbsA2	0.0003
4989	Cytochrome c551 peroxidase	ccp	0.0003
5222	Cytochrome c551 peroxidase	ccpA	0.0003
4961	Hemophore HasA	hasA	0.0003
4976	Apocytochrome f	petA	0.0003
6407	Apocytochrome f	petA	0.0003
4764	Cytochrome P450 165C4	CYP165C4	0.0003
4931	Cytochrome P450 167A1	CYP167A1	0.0003
4960	Putative cytochrome P450-family protein	SCO7417	0.0003
4937	Cytochrome oxidase subunit II	rcoxA	0.0003
4922	Cytochrome c, putative	SO_4144	0.0003
4926	Heme-based aerotactic transducer hemAT	hemAT	0.0003
4903	Methyl-accepting chemotaxis protein	Tar4	0.0003
4993	Hydroxylamine oxidoreductase	hao1	0.0003
4999	Cytochrome P450 165B3	CYP165B3	0.0003
4972	P450cin	cinA	0.0003
4970	Cytochrome c nitrite reductase catalytic subunit	nrfA	0.0003
6172	ATP-binding cassette sub-family B member 8, mitochondrial	ABCB8	0.0003
4952	Catalase/peroxidase	katA	0.0003
3093	Catalase HPII	katE	0.0003
4908	Heme-regulated cyclic AMP phosphodiesterase	dosP	0.0003
337	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial	NDUFS7	0.0002
803	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	NDUFS2	0.0002
214	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	NDUFS3	0.0002
6135	Sodium channel subunit beta-4	SCN4B	0.0002
6134	Sodium channel subunit beta-3	SCN3B	0.0002
6132	Sodium channel subunit beta-1	SCN1B	0.0002
6127	Carbonic anhydrase-related protein	CA8	0.0002
6128	Carbonic anhydrase-related protein 10	CA10	0.0002
6133	Sodium channel subunit beta-2	SCN2B	0.0002
6129	Carbonic anhydrase-related protein 11	CA11	0.0002
6861	Alcohol dehydrogenase [NADP+]	AKR1A1	0.0002
3803	Sodium channel protein type 3 subunit alpha	SCN3A	0.0002
6130	Carbonic anhydrase 13	CA13	0.0002
6124	Carbonic anhydrase 5B, mitochondrial	CA5B	0.0002
4920	Peroxidase/catalase	katG	0.0002
2119	Cytochrome b5	CYB5A	0.0002
4990	PpcA	ppcA	0.0002
4956	Quinohemoprotein alcohol dehydrogenase ADH IIB	qbdA	0.0002
3375	Acidic cytochrome c3	Not Available	0.0002
4988	Sulfite oxidase, mitochondrial	SUOX	0.0002
2915	Sensor protein fixL	fixL	0.0002
4944	Sensor protein fixL	fixL	0.0002
3570	Cytochrome P450 152A1	cypC	0.0002
4385	Cytochrome c'	Not Available	0.0002
4967	Cytochrome c'	cycA	0.0002
5038	Cytochrome c'	Not Available	0.0002
5223	Cytochrome c'	cycP	0.0002
4813	Heme oxygenase	hmuO	0.0002
5769	Heme oxygenase	Not Available	0.0002
4037	Hypothetical protein	GPX1	0.0002
4297	Hypothetical protein	SP_1951	0.0002
4521	Hypothetical protein	BC_2969	0.0002
4540	Hypothetical protein	TM_1070	0.0002
4555	Hypothetical protein	MT1739	0.0002
4569	Hypothetical protein	mshD	0.0002
4578	Hypothetical protein	PA3270	0.0002
4747	Hypothetical protein	PA3967	0.0002
5177	Hypothetical protein	TM_0096	0.0002
5194	Hypothetical protein	PA1204	0.0002
5240	Hypothetical protein	Rv2991	0.0002
5370	Hypothetical protein	TM_1158	0.0002
5710	Hypothetical protein	Tb927.5.1360	0.0002
4289	Cytochrome P450	TT_P0059	0.0002
6262	Cytochrome P450	staP	0.0002
4992	Cytochrome c peroxidase	Not Available	0.0002
2230	Catalase	CAT	0.0002
3249	Catalase	katA	0.0002
3625	Catalase	katA	0.0002
4539	Catalase	katA	0.0002
4941	Catalase	katB	0.0002
3670	Soluble cytochrome b562 precursor	cybC	0.0002
3411	Cytochrome P450 121	cyp121	0.0002
3291	Cytochrome c-552	cycA	0.0002
4927	Cytochrome c-552	nrfA	0.0002
4938	Cytochrome c-552	cycA	0.0002
4953	Cytochrome c-552	nrfA	0.0002
5217	Cytochrome c-552	cycM	0.0002
2617	Nitric oxide synthase oxygenase	nos	0.0002
2701	Nitric oxide synthase oxygenase	nos	0.0002
3102	Flavohemoprotein	hmp	0.0002
4969	Flavohemoprotein	hmp	0.0002
3007	Carbonic anhydrase 12	CA12	0.0002
4205	Carbonic anhydrase 9	CA9	0.0002
2845	Bifunctional P-450:NADPH-P450 reductase	CYP102A1	0.0001
2972	6-deoxyerythronolide B hydroxylase	eryF	0.0001
4608	Putative cytochrome P450	SCO1207	0.0001
4963	Putative cytochrome P450	SCO2884	0.0001
6254	Putative cytochrome P450	SCO6998	0.0001
358	Cystathionine beta-synthase	CBS	0.0001
693	Hemoglobin subunit beta	HBB	0.0001
6268	Hydroxyacid oxidase 1	HAO1	0.0001
810	Heme oxygenase 1	HMOX1	0.0001
3391	Heme oxygenase 1	pbsA1	0.0001

(*) Categorization taken from DrugBank: therapeutic category or general category of a drug (i.e. anti-convulsant, antibacterial, etc.)

DB00668 - Epinephrine

Targets

Enzymes

Transporters

Predictions