DT-Web: DB00321

Identification

Name

Amitriptyline

Accession Number

DB00321 (APRD00227)

Type

small molecule

Description

Amitriptyline hydrochloride is a dibenzocycloheptene-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, amitriptyline does not affect mood or arousal, but may cause sedation. In depressed individuals, amitriptyline exerts a positive effect on mood. TCAs are potent inhibitors of serotonin and norepinephrine reuptake. Tertiary amine TCAs, such as amitriptyline, are more potent inhibitors of serotonin reuptake than secondary amine TCAs, such as nortriptyline. TCAs also down-regulate cerebral cortical β-adrenergic receptors and sensitize post-synaptic serotonergic receptors with chronic use. The antidepressant effects of TCAs are thought to be due to an overall increase in serotonergic neurotransmission. TCAs also block histamine-H₁ receptors, α₁-adrenergic receptors and muscarinic receptors, which accounts for their sedative, hypotensive and anticholinergic effects (e.g. blurred vision, dry mouth, constipation, urinary retention), respectively. See toxicity section below for a complete listing of side effects. Amitriptyline may be used to treat depression, chronic pain (unlabeled use), irritable bowel syndrome (unlabeled use), diabetic neuropathy (unlabeled use), post-traumatic stress disorder (unlabeled use), and for migraine prophylaxis (unlabeled use).

Structure

MOL SDF PDB SMILES InChI

Categories ^(*)

Molecular Weight

277.4033

Groups

approved

Monoisotopic Weight

277.183049741

Pharmacology

Indication

For the treatment of depression, chronic pain, irritable bowel syndrome, sleep disorders, diabetic neuropathy, agitation and insomnia, and migraine prophylaxis.

Mechanism of action

Amitriptyline is metabolized to nortriptyline which inhibits the reuptake of norepinephrine and serotonin almost equally. Amitriptyline inhibits the membrane pump mechanism responsible for uptake of norepinephrine and serotonin in adrenergic and serotonergic neurons. Pharmacologically this action may potentiate or prolong neuronal activity since reuptake of these biogenic amines is important physiologically in terminating transmitting activity. This interference with the reuptake of norepinephrine and/or serotonin is believed by some to underlie the antidepressant activity of amitriptyline.

Absorption

Rapidly and well absorbed following oral administration (bioavailability is 30-60% due to first pass metabolism). Peak plasma concentrations occur 2-12 hours following oral or intramuscular administration.

Protein binding

Very highly protein bound (90% or more) in plasma and tissues

Biotransformation

Exclusively hepatic, with first pass effect. Amitriptyline is demethylated in the liver to its primary active metabolite, nortriptyline.

Route of elimination

Virtually the entire dose is excreted as glucuronide or sulfate conjugate of metabolites, with little unchanged drug appearing in the urine. 25-50% of a single orally administered dose is excreted in urine as inactive metabolites within 24 hours. Small amounts are excreted in feces via biliary elimination.

Toxicity

LD₅₀=350 mg/kg (in mice). Symptoms of overdose include abnormally low blood pressure, confusion, convulsions, dilated pupils and other eye problems, disturbed concentration, drowsiness, hallucinations, impaired heart function, rapid or irregular heartbeat, reduced body temperature, stupor, and unresponsiveness or coma. Side effects include: sedation, hypotension, blurred vision, dry mouth, constipation, urinary retention, postural hypotension, tachycardia, hypertension, ECG changes, heart failure, impaired memory and delirium, and precipitation of hypomanic or manic episodes in bipolar depression. Withdrawal symptoms include gastrointestinal disturbances, anxiety, and insomnia.

Affected organisms

Humans and other mammals

Interactions

Drug Interactions

Drug	Mechanism of interaction
Altretamine	Risk of severe hypotension
Artemether	Additive QTc-prolongation may occur. Concomitant therapy should be avoided.
Atazanavir	Atazanavir may increase the effect and toxicity of the tricyclic antidepressant, amitriptyline, by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of amitriptyline if atazanavir if initiated, discontinued or dose changed.
Butabarbital	Barbiturates like butabarbital may increase the metabolism of tricyclic antidepressants like amitriptyline. Monitor for decreased therapeutic effects of tricyclic antidepressants if a barbiturate is initiated/dose increased, or increased effects if a barbiturate is discontinued/dose decreased. The tricyclic antidepressant dosage will likely need to be increased during concomitant barbiturate therapy, and reduced upon barbiturate discontinuation.
Butalbital	Barbiturates such as butalbital may increase the metabolism of tricyclic antidepressants such as amitriptyline. Monitor for decreased therapeutic effects of tricyclic antidepressants if a barbiturate is initiated/dose increased, or increased effects if a barbiturate is discontinued/dose decreased. The tricyclic antidepressant dosage will likely need to be increased during concomitant barbiturate therapy, and reduced upon barbiturate discontinuation.
Carbamazepine	Carbamazepine may decrease the serum concentration of the tricyclic antidepressant, amitriptyline, by increasing its metabolism. Monitor for changes in the therapeutic and adverse effects of amitriptyline if carbamazepine is initiated, discontinued or dose changed.
Cimetidine	Cimetidine may increase the effect of the tricyclic antidepressant, amitriptyline, by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of amitriptyline if cimetidine is initiated, discontinued or dose changed.
Cisapride	Increased risk of cardiotoxicity and arrhythmias
Clonidine	The tricyclic antidepressant, amitriptyline, decreases the effect of clonidine.
Desvenlafaxine	Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Dihydroquinidine barbiturate	Dihydroquinidine barbiturate increases the effect of the tricyclic antidepressant, amitriptyline.
Dobutamine	The tricyclic antidepressant, amitriptyline, increases the sympathomimetic effect, dobutamine.
Donepezil	Possible antagonism of action
Dopamine	The tricyclic antidepressant, amitriptyline, increases the sympathomimetic effect, dopamine.
Duloxetine	Possible increase in the levels of this agent when used with duloxetine
Ephedra	The tricyclic antidepressant, amitriptyline, increases the sympathomimetic effect of ephedra.
Ephedrine	The tricyclic antidepressant, amitriptyline, increases the sympathomimetic effect of ephedrine.
Epinephrine	The tricyclic antidepressant, amitriptyline, may increase the sympathomimetic effect of epinephrine.
Fenoterol	The tricyclic antidepressant, amitriptyline, may increase the sympathomimetic effect of fenoterol.
Fluconazole	Fluconazole may increase the effect and toxicity of the tricyclic antidepressant, amitriptyline, by decreasing its metabolism. Additive QTc-prolonging effects may also occur. Monitor for changes in the therapeutic and adverse effects of amitriptyline if fluconazole is initiated, discontinued or dose changed. Monitor for the development of torsades de pointes during concomitant therapy.
Fluoxetine	The SSRI, fluoxetine, may increase the serum concentration of the tricyclic antidepressant, amitriptyline, by decreasing its metabolism. Additive modulation of serotonin activity also increases the risk of serotonin syndrome. Monitor for development of serotonin syndrome during concomitant therapy. Monitor for changes in the therapeutic and adverse effects of amitriptyline if fluoxetine is initiated, discontinued or dose changed.
Fluvoxamine	The SSRI, fluvoxamine, may increase the serum concentration of the tricyclic antidepressant, amitriptyline, by decreasing its metabolism. Additive modulation of serotonin activity also increases the risk of serotonin syndrome. Monitor for development of serotonin syndrome during concomitant therapy. Monitor for changes in the therapeutic and adverse effects of amitriptyline if fluvoxamine is initiated, discontinued or dose changed.
Galantamine	Possible antagonism of action
Grepafloxacin	Increased risk of cardiotoxicity and arrhythmias
Guanethidine	The tricyclic antidepressant, amitriptyline, decreases the effect of guanethidine.
Indacaterol	Concomitant therapy with monoamine oxidase inhibitors, tricyclic antidepressants, or other drugs that prolong the QTc interval should be monitored closely. These drugs may potentiate the effect of adrenergic agonist on the cardiovascular system.
Iobenguane	May diminish the therapeutic effect and increase chances of producing a false negative imaging result of Iobenguane as it inhibits noradrenaline transporter function
Isocarboxazid	Possibility of severe adverse effects
Isoproterenol	The tricyclic antidepressant, amitriptyline, increases the sympathomimetic effect of isoproterenol.
Ketoconazole	Ketoconazole, a moderate CYP2D6 inhibitor, may increase the serum concentration of amitriptyline by increasing its metabolism. Monitor for changes in the therapeutic and adverse effects of amitriptyline if ketoconazole is initiated, discontinued or dose changed.
Lumefantrine	Additive QTc-prolongation may occur. Concomitant therapy should be avoided.
Mephentermine	The tricyclic antidepressant, amitriptyline, increases the sympathomimetic effect of mephentermine.
Mesoridazine	Increased risk of cardiotoxicity and arrhythmias
Metaraminol	The tricyclic antidepressant, amitriptyline, increases the sympathomimetic effect of metaraminol.
Methoxamine	The tricyclic antidepressant, amitriptyline, increases the sympathomimetic effect of methoxamine.
Moclobemide	Possible severe adverse reaction with this combination
Norepinephrine	The tricyclic antidepressant, amitriptyline, increases the sympathomimetic effect of norepinephrine.
Orciprenaline	The tricyclic antidepressant, amitriptyline, increases the sympathomimetic effect of orciprenaline.
Phenelzine	Possibility of severe adverse effects
Phenylephrine	The tricyclic antidepressant, amitriptyline, increases the sympathomimetic effect of phenylephrine.
Phenylpropanolamine	The tricyclic antidepressant, amitriptyline, increases the sympathomimetic effect of phenylpropanolamine.
Pirbuterol	The tricyclic antidepressant, amitriptyline, increases the sympathomimetic effect of pirbuterol.
Procaterol	The tricyclic antidepressant, amitriptyline, increases the sympathomimetic effect of procaterol.
Pseudoephedrine	The tricyclic antidepressant, amitriptyline, increases the sympathomimetic effect of pseudoephedrine.
Quinidine	Additive QTc-prolonging effects may occur. Quinidine may also increase the serum concentration of the tricyclic antidepressant, amitriptyline, by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of amitriptyline if quinidine is initiated, discontinued or dose changed. Monitor for the development of torsades de pointes during concomitant therapy.
Quinidine barbiturate	Quinidine barbiturate increases the effect of tricyclic antidepressant, amitriptyline.
Rasagiline	Possibility of severe adverse effects
Rifabutin	The rifamycin, rifabutin, may decrease the effect of the tricyclic antidepressant, amitriptyline, by increasing its metabolism. Monitor for changes in the therapeutic and adverse effects of amitriptyline if rifabutin is initiated, discontinued or dose changed.
Rifampin	The rifamycin, rifampin, may decrease the effect of the tricyclic antidepressant, amitriptyline, by increasing its metabolism. Monitor for changes in the therapeutic and adverse effects of amitriptyline if rifampin is initiated, discontinued or dose changed.
Ritonavir	Ritonavir may increase the effect and toxicity of the tricyclic antidepressant, amitriptyline, by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of amitriptyline if ritonavir if initiated, discontinued or dose changed.
Rivastigmine	Possible antagonism of action
Salbutamol	The tricyclic antidepressant, amitriptyline, increases the sympathomimetic effect of salbutamol.
Sibutramine	Increased risk of CNS adverse effects
Sparfloxacin	Increased risk of cardiotoxicity and arrhythmias
Tacrine	The therapeutic effects of the central acetylcholinesterase inhibitor, Tacrine, and/or the anticholinergic, Amitriptyline, may be reduced due to antagonism. The interaction may be beneficial when the anticholinergic action is a side effect. Monitor for decreased efficacy of both agents.
Tacrolimus	Additive QTc-prolongation may occur increasing the risk of serious ventricular arrhythmias. Concomitant therapy should be used with caution.
Terbinafine	Terbinafine may reduce the metabolism and clearance of Amitryptyline. Consider alternate therapy or monitor for therapeutic/adverse effects of Amytriptyline if Terbinafine is initiated, discontinued or dose changed.
Terbutaline	The tricyclic antidepressant, amitriptyline, increases the sympathomimetic effect of terbutaline.
Terfenadine	Increased risk of cardiotoxicity and arrhythmias
Thioridazine	Increased risk of cardiotoxicity and arrhythmias
Thiothixene	May cause additive QTc-prolonging effects. Increased risk of ventricular arrhythmias. Consider alternate therapy. Thorough risk:benefit assessment is required prior to co-administration.
Toremifene	Additive QTc-prolongation may occur, increasing the risk of serious ventricular arrhythmias. Consider alternate therapy. A thorough risk:benefit assessment is required prior to co-administration.
Tramadol	Tramadol increases the risk of serotonin syndrome and seizures.
Tranylcypromine	Increased risk of serotonin syndrome. Concomitant therapy should be avoided. A significant washout period, dependent on the half-lives of the agents, should be employed between therapies.
Trazodone	Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Trimethobenzamide	Trimethobenzamide and Amitriptyline, two anticholinergics, may cause additive anticholinergic effects and enhance their adverse/toxic effects. Monitor for enhanced anticholinergic effects.
Trimipramine	Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome. Additive QTc-prolongation may also occur, increasing the risk of serious ventricular arrhythmias. Concomitant therapy should be used with caution.
Triprolidine	Triprolidine and Amitriptyline, two anticholinergics, may cause additive anticholinergic effects and enhance their adverse/toxic effects. Additive CNS depressant effects may also occur. Monitor for enhanced anticholinergic and CNS depressant effects.
Trospium	Trospium and Amitriptyline, two anticholinergics, may cause additive anticholinergic effects and enhanced adverse/toxic effects. Monitor for enhanced anticholinergic effects.
Venlafaxine	Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Vilazodone	Monitor for toxic effects of tricyclic antidepressants if a selective serotonin reuptake inhibitor (SSRI) is initiated or the dose is increased. The influence of the SSRI may take several days or weeks to be fully realized or resolved.
Voriconazole	Additive QTc prolongation may occur. Consider alternate therapy or monitor for QTc prolongation as this can lead to Torsade de Pointes (TdP).
Vorinostat	Additive QTc prolongation may occur. Consider alternate therapy or monitor for QTc prolongation as this can lead to Torsade de Pointes (TdP).
Ziprasidone	Additive QTc-prolonging effects may increase the risk of severe arrhythmias. Concomitant therapy is contraindicated.
Zolmitriptan	Use of two serotonin modulators, such as zolmitriptan and amitriptyline, increases the risk of serotonin syndrome. Consider alternate therapy or monitor for serotonin syndrome during concomitant therapy.
Zuclopenthixol	Additive QTc prolongation may occur. Consider alternate therapy or use caution and monitor for QTc prolongation as this can lead to Torsade de Pointes (TdP).

Food Interactions

Avoid excessive quantities of coffee or tea (Caffeine).
Take with food to reduce irritation.
Avoid St.John's Wort.
Avoid alcohol.

Sodium-dependent noradrenaline transporter
Name	Sodium-dependent noradrenaline transporter
Gene Name	SLC6A2
Pharmacological action	yes
Actions	inhibitor
References	Vaishnavi SN, Nemeroff CB, Plott SJ, Rao SG, Kranzler J, Owens MJ: Milnacipran: a comparative analysis of human monoamine uptake and transporter binding affinity. Biol Psychiatry. 2004 Feb 1;55(3):320-2. - Pubmed Tatsumi M, Groshan K, Blakely RD, Richelson E: Pharmacological profile of antidepressants and related compounds at human monoamine transporters. Eur J Pharmacol. 1997 Dec 11;340(2-3):249-58. - Pubmed
DTHybrid score	0.7586
Sodium-dependent serotonin transporter
Name	Sodium-dependent serotonin transporter
Gene Name	SLC6A4
Pharmacological action	yes
Actions	inhibitor
References	Gould GG, Altamirano AV, Javors MA, Frazer A: A comparison of the chronic treatment effects of venlafaxine and other antidepressants on serotonin and norepinephrine transporters. Biol Psychiatry. 2006 Mar 1;59(5):408-14. Epub 2005 Sep 2. - Pubmed Troelsen KB, Nielsen EO, Mirza NR: Chronic treatment with duloxetine is necessary for an anxiolytic-like response in the mouse zero maze: the role of the serotonin transporter. Psychopharmacology (Berl). 2005 Oct;181(4):741-50. Epub 2005 Sep 29. - Pubmed Vaishnavi SN, Nemeroff CB, Plott SJ, Rao SG, Kranzler J, Owens MJ: Milnacipran: a comparative analysis of human monoamine uptake and transporter binding affinity. Biol Psychiatry. 2004 Feb 1;55(3):320-2. - Pubmed Ushijima K, Sakaguchi H, Sato Y, To H, Koyanagi S, Higuchi S, Ohdo S: Chronopharmacological study of antidepressants in forced swimming test of mice. J Pharmacol Exp Ther. 2005 Nov;315(2):764-70. Epub 2005 Aug 3. - Pubmed Kalia M: Neurobiological basis of depression: an update. Metabolism. 2005 May;54(5 Suppl 1):24-7. - Pubmed Tatsumi M, Groshan K, Blakely RD, Richelson E: Pharmacological profile of antidepressants and related compounds at human monoamine transporters. Eur J Pharmacol. 1997 Dec 11;340(2-3):249-58. - Pubmed
DTHybrid score	0.6288
5-hydroxytryptamine 2A receptor
Name	5-hydroxytryptamine 2A receptor
Gene Name	HTR2A
Pharmacological action	yes
Actions	antagonist
References	Cusack B, Nelson A, Richelson E: Binding of antidepressants to human brain receptors: focus on newer generation compounds. Psychopharmacology (Berl). 1994 May;114(4):559-65. - Pubmed
DTHybrid score	0.6176
5-hydroxytryptamine 1A receptor
Name	5-hydroxytryptamine 1A receptor
Gene Name	HTR1A
Pharmacological action	unknown
Actions	unknown
References	Cusack B, Nelson A, Richelson E: Binding of antidepressants to human brain receptors: focus on newer generation compounds. Psychopharmacology (Berl). 1994 May;114(4):559-65. - Pubmed
DTHybrid score	0.4612
Delta-type opioid receptor
Name	Delta-type opioid receptor
Gene Name	OPRD1
Pharmacological action	unknown
Actions	agonist
References	Onali P, Dedoni S, Olianas MC: Direct agonist activity of tricyclic antidepressants at distinct opioid receptor subtypes. J Pharmacol Exp Ther. 2010 Jan;332(1):255-65. Epub 2009 Oct 14. - Pubmed
DTHybrid score	0.6568
Kappa-type opioid receptor
Name	Kappa-type opioid receptor
Gene Name	OPRK1
Pharmacological action	unknown
Actions	agonist
References	Onali P, Dedoni S, Olianas MC: Direct agonist activity of tricyclic antidepressants at distinct opioid receptor subtypes. J Pharmacol Exp Ther. 2010 Jan;332(1):255-65. Epub 2009 Oct 14. - Pubmed
DTHybrid score	0.6578
High affinity nerve growth factor receptor
Name	High affinity nerve growth factor receptor
Gene Name	NTRK1
Pharmacological action	unknown
Actions	agonist
References	Jang SW, Liu X, Chan CB, Weinshenker D, Hall RA, Xiao G, Ye K: Amitriptyline is a TrkA and TrkB receptor agonist that promotes TrkA/TrkB heterodimerization and has potent neurotrophic activity. Chem Biol. 2009 Jun 26;16(6):644-56. - Pubmed
DTHybrid score	0.1594
BDNF/NT-3 growth factors receptor
Name	BDNF/NT-3 growth factors receptor
Gene Name	NTRK2
Pharmacological action	unknown
Actions	agonist
References	Jang SW, Liu X, Chan CB, Weinshenker D, Hall RA, Xiao G, Ye K: Amitriptyline is a TrkA and TrkB receptor agonist that promotes TrkA/TrkB heterodimerization and has potent neurotrophic activity. Chem Biol. 2009 Jun 26;16(6):644-56. - Pubmed
DTHybrid score	0.1545
Alpha-1A adrenergic receptor
Name	Alpha-1A adrenergic receptor
Gene Name	ADRA1A
Pharmacological action	no
Actions	antagonist
References	Cusack B, Nelson A, Richelson E: Binding of antidepressants to human brain receptors: focus on newer generation compounds. Psychopharmacology (Berl). 1994 May;114(4):559-65. - Pubmed Nojimoto FD, Mueller A, Hebeler-Barbosa F, Akinaga J, Lima V, Kiguti LR, Pupo AS: The tricyclic antidepressants amitriptyline, nortriptyline and imipramine are weak antagonists of human and rat alpha1B-adrenoceptors. Neuropharmacology. 2010 Jul-Aug;59(1-2):49-57. Epub 2010 Apr 2. - Pubmed
DTHybrid score	0.8297
Alpha-1D adrenergic receptor
Name	Alpha-1D adrenergic receptor
Gene Name	ADRA1D
Pharmacological action	no
Actions	antagonist
References	Nojimoto FD, Mueller A, Hebeler-Barbosa F, Akinaga J, Lima V, Kiguti LR, Pupo AS: The tricyclic antidepressants amitriptyline, nortriptyline and imipramine are weak antagonists of human and rat alpha1B-adrenoceptors. Neuropharmacology. 2010 Jul-Aug;59(1-2):49-57. Epub 2010 Apr 2. - Pubmed
DTHybrid score	0.4079
Alpha-2A adrenergic receptor
Name	Alpha-2A adrenergic receptor
Gene Name	ADRA2A
Pharmacological action	no
Actions	antagonist
References	Cusack B, Nelson A, Richelson E: Binding of antidepressants to human brain receptors: focus on newer generation compounds. Psychopharmacology (Berl). 1994 May;114(4):559-65. - Pubmed Ozdogan UK, Lahdesmaki J, Mansikka H, Scheinin M: Loss of amitriptyline analgesia in alpha 2A-adrenoceptor deficient mice. Eur J Pharmacol. 2004 Feb 6;485(1-3):193-6. - Pubmed
DTHybrid score	0.6026
Histamine H1 receptor
Name	Histamine H1 receptor
Gene Name	HRH1
Pharmacological action	no
Actions	antagonist
References	Cusack B, Nelson A, Richelson E: Binding of antidepressants to human brain receptors: focus on newer generation compounds. Psychopharmacology (Berl). 1994 May;114(4):559-65. - Pubmed
DTHybrid score	0.9195
Muscarinic acetylcholine receptor M1
Name	Muscarinic acetylcholine receptor M1
Gene Name	CHRM1
Pharmacological action	no
Actions	antagonist
References	Cusack B, Nelson A, Richelson E: Binding of antidepressants to human brain receptors: focus on newer generation compounds. Psychopharmacology (Berl). 1994 May;114(4):559-65. - Pubmed
DTHybrid score	1.153
Muscarinic acetylcholine receptor M2
Name	Muscarinic acetylcholine receptor M2
Gene Name	CHRM2
Pharmacological action	no
Actions	antagonist
References	Cusack B, Nelson A, Richelson E: Binding of antidepressants to human brain receptors: focus on newer generation compounds. Psychopharmacology (Berl). 1994 May;114(4):559-65. - Pubmed
DTHybrid score	0.9887
Muscarinic acetylcholine receptor M3
Name	Muscarinic acetylcholine receptor M3
Gene Name	CHRM3
Pharmacological action	no
Actions	antagonist
References	Cusack B, Nelson A, Richelson E: Binding of antidepressants to human brain receptors: focus on newer generation compounds. Psychopharmacology (Berl). 1994 May;114(4):559-65. - Pubmed
DTHybrid score	1.0012
Muscarinic acetylcholine receptor M4
Name	Muscarinic acetylcholine receptor M4
Gene Name	CHRM4
Pharmacological action	no
Actions	antagonist
References	Cusack B, Nelson A, Richelson E: Binding of antidepressants to human brain receptors: focus on newer generation compounds. Psychopharmacology (Berl). 1994 May;114(4):559-65. - Pubmed
DTHybrid score	0.7362
Muscarinic acetylcholine receptor M5
Name	Muscarinic acetylcholine receptor M5
Gene Name	CHRM5
Pharmacological action	no
Actions	antagonist
References	Cusack B, Nelson A, Richelson E: Binding of antidepressants to human brain receptors: focus on newer generation compounds. Psychopharmacology (Berl). 1994 May;114(4):559-65. - Pubmed
DTHybrid score	0.6413
Potassium voltage-gated channel subfamily KQT member 2
Name	Potassium voltage-gated channel subfamily KQT member 2
Gene Name	KCNQ2
Pharmacological action	no
Actions	inhibitor
References	Punke MA, Friederich P: Amitriptyline is a potent blocker of human Kv1.1 and Kv7.2/7.3 channels. Anesth Analg. 2007 May;104(5):1256-64, tables of contents. - Pubmed
DTHybrid score	0.216
Potassium voltage-gated channel subfamily A member 1
Name	Potassium voltage-gated channel subfamily A member 1
Gene Name	KCNA1
Pharmacological action	no
Actions	inhibitor
References	Punke MA, Friederich P: Amitriptyline is a potent blocker of human Kv1.1 and Kv7.2/7.3 channels. Anesth Analg. 2007 May;104(5):1256-64, tables of contents. - Pubmed
DTHybrid score	0.3646
Potassium voltage-gated channel subfamily D member 2
Name	Potassium voltage-gated channel subfamily D member 2
Gene Name	KCND2
Pharmacological action	no
Actions	inhibitor
References	Casis O, Sanchez-Chapula JA: Disopyramide, imipramine, and amitriptyline bind to a common site on the transient outward K+ channel. J Cardiovasc Pharmacol. 1998 Oct;32(4):521-6. - Pubmed
DTHybrid score	0.4722
Potassium voltage-gated channel subfamily D member 3
Name	Potassium voltage-gated channel subfamily D member 3
Gene Name	KCND3
Pharmacological action	no
Actions	inhibitor
References	Casis O, Sanchez-Chapula JA: Disopyramide, imipramine, and amitriptyline bind to a common site on the transient outward K+ channel. J Cardiovasc Pharmacol. 1998 Oct;32(4):521-6. - Pubmed
DTHybrid score	0.4722

Cytochrome P450 2D6
Name	Cytochrome P450 2D6
Gene Name	CYP2D6
Actions	substrate,inhibitor
References	Baumann P: Pharmacokinetic-pharmacodynamic relationship of the selective serotonin reuptake inhibitors. Clin Pharmacokinet. 1996 Dec;31(6):444-69. - Pubmed Wen B, Ma L, Zhu M: Bioactivation of the tricyclic antidepressant amitriptyline and its metabolite nortriptyline to arene oxide intermediates in human liver microsomes and recombinant P450s. Chem Biol Interact. 2008 May 9;173(1):59-67. Epub 2008 Feb 14. - Pubmed Ghahramani P, Ellis SW, Lennard MS, Ramsay LE, Tucker GT: Cytochromes P450 mediating the N-demethylation of amitriptyline. Br J Clin Pharmacol. 1997 Feb;43(2):137-44. - Pubmed Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed Venkatakrishnan K, von Moltke LL, Greenblatt DJ: Application of the relative activity factor approach in scaling from heterologously expressed cytochromes p450 to human liver microsomes: studies on amitriptyline as a model substrate. J Pharmacol Exp Ther. 2001 Apr;297(1):326-37. - Pubmed
DTHybrid score	1.2899
Cytochrome P450 1A2
Name	Cytochrome P450 1A2
Gene Name	CYP1A2
Actions	substrate
References	Wen B, Ma L, Zhu M: Bioactivation of the tricyclic antidepressant amitriptyline and its metabolite nortriptyline to arene oxide intermediates in human liver microsomes and recombinant P450s. Chem Biol Interact. 2008 May 9;173(1):59-67. Epub 2008 Feb 14. - Pubmed Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table Information Hyperlinked Over Proteins (iHOP) - - Website Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed Venkatakrishnan K, von Moltke LL, Greenblatt DJ: Application of the relative activity factor approach in scaling from heterologously expressed cytochromes p450 to human liver microsomes: studies on amitriptyline as a model substrate. J Pharmacol Exp Ther. 2001 Apr;297(1):326-37. - Pubmed
DTHybrid score	0.8814
Cytochrome P450 2C19
Name	Cytochrome P450 2C19
Gene Name	CYP2C19
Actions	substrate,inhibitor
References	Shin JG, Park JY, Kim MJ, Shon JH, Yoon YR, Cha IJ, Lee SS, Oh SW, Kim SW, Flockhart DA: Inhibitory effects of tricyclic antidepressants (TCAs) on human cytochrome P450 enzymes in vitro: mechanism of drug interaction between TCAs and phenytoin. Drug Metab Dispos. 2002 Oct;30(10):1102-7. - Pubmed Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed Venkatakrishnan K, von Moltke LL, Greenblatt DJ: Application of the relative activity factor approach in scaling from heterologously expressed cytochromes p450 to human liver microsomes: studies on amitriptyline as a model substrate. J Pharmacol Exp Ther. 2001 Apr;297(1):326-37. - Pubmed
DTHybrid score	0.8362
Cytochrome P450 2C9
Name	Cytochrome P450 2C9
Gene Name	CYP2C9
Actions	substrate
References	Ghahramani P, Ellis SW, Lennard MS, Ramsay LE, Tucker GT: Cytochromes P450 mediating the N-demethylation of amitriptyline. Br J Clin Pharmacol. 1997 Feb;43(2):137-44. - Pubmed Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed Venkatakrishnan K, von Moltke LL, Greenblatt DJ: Application of the relative activity factor approach in scaling from heterologously expressed cytochromes p450 to human liver microsomes: studies on amitriptyline as a model substrate. J Pharmacol Exp Ther. 2001 Apr;297(1):326-37. - Pubmed
DTHybrid score	0.9194
Cytochrome P450 3A4
Name	Cytochrome P450 3A4
Gene Name	CYP3A4
Actions	substrate
References	Wen B, Ma L, Zhu M: Bioactivation of the tricyclic antidepressant amitriptyline and its metabolite nortriptyline to arene oxide intermediates in human liver microsomes and recombinant P450s. Chem Biol Interact. 2008 May 9;173(1):59-67. Epub 2008 Feb 14. - Pubmed Ghahramani P, Ellis SW, Lennard MS, Ramsay LE, Tucker GT: Cytochromes P450 mediating the N-demethylation of amitriptyline. Br J Clin Pharmacol. 1997 Feb;43(2):137-44. - Pubmed Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed Venkatakrishnan K, von Moltke LL, Greenblatt DJ: Application of the relative activity factor approach in scaling from heterologously expressed cytochromes p450 to human liver microsomes: studies on amitriptyline as a model substrate. J Pharmacol Exp Ther. 2001 Apr;297(1):326-37. - Pubmed
DTHybrid score	1.5042
Cytochrome P450 3A5
Name	Cytochrome P450 3A5
Gene Name	CYP3A5
Actions	substrate
References	Wen B, Ma L, Zhu M: Bioactivation of the tricyclic antidepressant amitriptyline and its metabolite nortriptyline to arene oxide intermediates in human liver microsomes and recombinant P450s. Chem Biol Interact. 2008 May 9;173(1):59-67. Epub 2008 Feb 14. - Pubmed
DTHybrid score	0.6147
Cytochrome P450 2B6
Name	Cytochrome P450 2B6
Gene Name	CYP2B6
Actions	substrate
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed Venkatakrishnan K, von Moltke LL, Greenblatt DJ: Application of the relative activity factor approach in scaling from heterologously expressed cytochromes p450 to human liver microsomes: studies on amitriptyline as a model substrate. J Pharmacol Exp Ther. 2001 Apr;297(1):326-37. - Pubmed
DTHybrid score	0.6296
Cytochrome P450 2C8
Name	Cytochrome P450 2C8
Gene Name	CYP2C8
Actions	substrate,inhibitor
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed Venkatakrishnan K, von Moltke LL, Greenblatt DJ: Application of the relative activity factor approach in scaling from heterologously expressed cytochromes p450 to human liver microsomes: studies on amitriptyline as a model substrate. J Pharmacol Exp Ther. 2001 Apr;297(1):326-37. - Pubmed
DTHybrid score	0.6449
Cytochrome P450 2E1
Name	Cytochrome P450 2E1
Gene Name	CYP2E1
Actions	substrate,inhibitor
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.6593

Multidrug resistance protein 1
Name	Multidrug resistance protein 1
Gene Name	ABCB1
Actions	substrate,inhibitor
References	Mahar Doan KM, Humphreys JE, Webster LO, Wring SA, Shampine LJ, Serabjit-Singh CJ, Adkison KK, Polli JW: Passive permeability and P-glycoprotein-mediated efflux differentiate central nervous system (CNS) and non-CNS marketed drugs. J Pharmacol Exp Ther. 2002 Dec;303(3):1029-37. - Pubmed Faassen F, Vogel G, Spanings H, Vromans H: Caco-2 permeability, P-glycoprotein transport ratios and brain penetration of heterocyclic drugs. Int J Pharm. 2003 Sep 16;263(1-2):113-22. - Pubmed
DTHybrid score	0.9086

Multidrug resistance protein 1
Name	Multidrug resistance protein 1
Gene Name	ABCB1
Actions
References	Not Available
DTHybrid score	0.9086

Id	Partner name	Gene Name	Score
847	Mu-type opioid receptor	OPRM1	0.5849
6107	Cytochrome P450 3A7	CYP3A7	0.4225
632	Alpha-1B adrenergic receptor	ADRA1B	0.3913
831	D(2) dopamine receptor	DRD2	0.3832
590	5-hydroxytryptamine 2C receptor	HTR2C	0.329
713	Sodium-dependent dopamine transporter	SLC6A3	0.3041
23	D(1A) dopamine receptor	DRD1	0.2968
6024	Cytochrome P450 1A1	CYP1A1	0.2521
5718	Cytochrome P450 2A6	CYP2A6	0.2458
629	Alpha-2B adrenergic receptor	ADRA2B	0.2419
378	Alpha-2C adrenergic receptor	ADRA2C	0.2303
6145	Solute carrier family 22 member 1	SLC22A1	0.2246
20	Prostaglandin G/H synthase 1	PTGS1	0.2103
1732	ATP-binding cassette sub-family G member 2	ABCG2	0.1951
6144	Solute carrier family 22 member 2	SLC22A2	0.1847
638	D(3) dopamine receptor	DRD3	0.1723
432	D(4) dopamine receptor	DRD4	0.1695
885	5-hydroxytryptamine 1B receptor	HTR1B	0.1643
6106	Cytochrome P450 2C18	CYP2C18	0.1614
436	5-hydroxytryptamine 2B receptor	HTR2B	0.1519
725	5-hydroxytryptamine 1D receptor	HTR1D	0.1511
766	Beta-2 adrenergic receptor	ADRB2	0.1504
220	Sodium channel protein type 5 subunit alpha	SCN5A	0.1464
3941	Amine oxidase [flavin-containing] A	MAOA	0.1454
193	Beta-1 adrenergic receptor	ADRB1	0.1447
3923	Cholinesterase	BCHE	0.1357
6022	UDP-glucuronosyltransferase 1-1	UGT1A1	0.1294
872	Gamma-aminobutyric-acid receptor subunit alpha-1	GABRA1	0.1267
716	5-hydroxytryptamine 7 receptor	HTR7	0.1255
1729	Solute carrier family 22 member 6	SLC22A6	0.1203
6018	UDP-glucuronosyltransferase 1-9	UGT1A9	0.1193
163	D(1B) dopamine receptor	DRD5	0.1182
290	Prostaglandin G/H synthase 2	PTGS2	0.1179
6139	Solute carrier organic anion transporter family member 1A2	SLCO1A2	0.1138
341	5-hydroxytryptamine 3 receptor	HTR3A	0.1137
1735	Canalicular multispecific organic anion transporter 1	ABCC2	0.1123
1490	Solute carrier organic anion transporter family member 1B1	SLCO1B1	0.112
101	Potassium voltage-gated channel subfamily H member 2	KCNH2	0.106
4162	Potassium voltage-gated channel subfamily KQT member 3	KCNQ3	0.1049
862	Multidrug resistance-associated protein 1	ABCC1	0.1032
465	Calmodulin	CALM1	0.1016
705	Glutamate receptor 1	GRIA1	0.1012
6178	UDP-glucuronosyltransferase 2B7	UGT2B7	0.1006
241	Calcium-transporting ATPase type 2C member 1	ATP2C1	0.1
131	Synaptic vesicular amine transporter	SLC18A2	0.0978
537	ATP synthase delta chain, mitochondrial	ATP5D	0.0973
118	Organic cation/carnitine transporter 2	SLC22A5	0.0964
482	Glycine receptor subunit alpha-1	GLRA1	0.0943
1256	5-hydroxytryptamine 6 receptor	HTR6	0.0926
6147	Solute carrier family 22 member 3	SLC22A3	0.0921
6176	UDP-glucuronosyltransferase 1-3	UGT1A3	0.0915
813	Neuronal acetylcholine receptor subunit alpha-2	CHRNA2	0.0912
559	NADH-ubiquinone oxidoreductase chain 1	MT-ND1	0.0894
833	Organic cation/carnitine transporter 1	SLC22A4	0.0883
3939	Amine oxidase [flavin-containing] B	MAOB	0.0873
1716	Tripartite motif-containing protein 13	TRIM13	0.0816
3811	Cytochrome P450 19A1	CYP19A1	0.075
1898	Cytochrome P450 1B1	CYP1B1	0.0746
706	Glutamate [NMDA] receptor subunit 3A	GRIN3A	0.0697
6432	Transporter	snf	0.0688
528	5-hydroxytryptamine 1E receptor	HTR1E	0.0659
1262	Corticotropin-lipotropin	POMC	0.0642
124	Histamine H2 receptor	HRH2	0.0623
776	Bile salt export pump	ABCB11	0.0607
6142	Solute carrier family 22 member 8	SLC22A8	0.06
2164	Multidrug resistance-associated protein 4	ABCC4	0.0595
6158	Solute carrier organic anion transporter family member 1C1	SLCO1C1	0.0583
1656	CYP2B protein	CYP2B	0.0578
6025	UDP-glucuronosyltransferase 1-4	UGT1A4	0.057
4115	Voltage-dependent L-type calcium channel subunit alpha-1D	CACNA1D	0.0569
136	Estrogen receptor	ESR1	0.0566
94	5-hydroxytryptamine 4 receptor	HTR4	0.0562
478	Voltage-dependent L-type calcium channel subunit alpha-1C	CACNA1C	0.0556
1632	Solute carrier organic anion transporter family member 2B1	SLCO2B1	0.055
1517	Beta-3 adrenergic receptor	ADRB3	0.0536
6157	Solute carrier organic anion transporter family member 1B3	SLCO1B3	0.0536
504	Mast/stem cell growth factor receptor	KIT	0.0525
275	Arachidonate 5-lipoxygenase	ALOX5	0.0524
174	Sigma 1-type opioid receptor	SIGMAR1	0.0499
6101	Dimethylaniline monooxygenase [N-oxide-forming] 3	FMO3	0.0491
4110	Voltage-dependent L-type calcium channel subunit beta-2	CACNB2	0.049
731	HIV-1 protease	HIV-1 protease	0.0483
228	Beta platelet-derived growth factor receptor	PDGFRB	0.0478
6182	Cytochrome P450 2J2	CYP2J2	0.0474
6102	Arylamine N-acetyltransferase 2	NAT2	0.0471
950	Alpha platelet-derived growth factor receptor	PDGFRA	0.047
6017	Cholesterol side-chain cleavage enzyme, mitochondrial	CYP11A1	0.0463
260	Cytochrome P450 51	ERG11	0.0459
761	Cytochrome P450 51	ERG11	0.0459
3163	Cytochrome P450 51	cyp51	0.0459
1709	Canalicular multispecific organic anion transporter 2	ABCC3	0.0458
6143	Solute carrier family 22 member 7	SLC22A7	0.0452
871	Glucocorticoid receptor	NR3C1	0.0449
891	Dihydropteroate synthase	folP	0.0445
5359	Dihydropteroate synthase	folP	0.0445
7175	Dihydropteroate synthase	sulI	0.0445
4111	Voltage-dependent L-type calcium channel subunit alpha-1S	CACNA1S	0.044
401	Glutamate [NMDA] receptor subunit zeta-1	GRIN1	0.0436
4163	Potassium voltage-gated channel subfamily KQT member 4	KCNQ4	0.0436
4164	Potassium voltage-gated channel subfamily KQT member 5	KCNQ5	0.0435
17	Proto-oncogene tyrosine-protein kinase ABL1	ABL1	0.0426
514	Potassium voltage-gated channel subfamily H member 6	KCNH6	0.0422
772	Potassium voltage-gated channel subfamily H member 7	KCNH7	0.0422
6180	UDP-glucuronosyltransferase 2B4	UGT2B4	0.041
580	Gamma-aminobutyric-acid receptor subunit alpha-3	GABRA3	0.0409
1539	Oligopeptide transporter, small intestine isoform	SLC15A1	0.0408
423	Gamma-aminobutyric-acid receptor subunit alpha-2	GABRA2	0.0407
6104	Dimethylaniline monooxygenase [N-oxide-forming] 1	FMO1	0.0403
787	Vitamin K epoxide reductase complex subunit 1	VKORC1	0.04
1024	Solute carrier family 22 member 11	SLC22A11	0.0394
6031	Cytochrome P450 3A43	CYP3A43	0.0389
5878	Alpha-7 nicotinic cholinergic receptor subunit	CHRFAM7A	0.0389
474	Acetylcholinesterase	ACHE	0.0387
198	Sodium channel protein type 10 subunit alpha	SCN10A	0.0387
468	Cytochrome P450 4A11	CYP4A11	0.0382
805	Cytochrome P450 11B1, mitochondrial	CYP11B1	0.0381
762	Voltage-dependent calcium channel subunit alpha-2/delta-1	CACNA2D1	0.038
523	Gamma-aminobutyric-acid receptor subunit alpha-5	GABRA5	0.0376
844	Epidermal growth factor receptor	EGFR	0.0374
319	Opioid receptor, sigma 1	OPRS1	0.0373
817	DNA topoisomerase 2-alpha	TOP2A	0.0365
122	P2Y purinoceptor 12	P2RY12	0.0347
535	Voltage-dependent T-type calcium channel subunit alpha-1G	CACNA1G	0.0341
26	Vascular endothelial growth factor receptor 3	FLT4	0.0335
698	B-Raf proto-oncogene serine/threonine-protein kinase	BRAF	0.0333
2129	Sucrase-isomaltase, intestinal	SI	0.0331
964	Voltage-dependent T-type calcium channel subunit alpha-1H	CACNA1H	0.0328
36	Insulin receptor	INSR	0.0325
32	Vascular endothelial growth factor receptor 1	FLT1	0.0322
631	3-hydroxy-3-methylglutaryl-coenzyme A reductase	HMGCR	0.0307
3387	3-hydroxy-3-methylglutaryl-coenzyme A reductase	mvaA	0.0307
407	Vascular endothelial growth factor receptor 2	KDR	0.0302
1864	RET proto-oncogene	RET	0.0293
1950	Epithelial discoidin domain-containing receptor 1	DDR1	0.0293
530	Gamma-aminobutyric-acid receptor subunit alpha-4	GABRA4	0.0292
511	5-hydroxytryptamine 1F receptor	HTR1F	0.0292
6094	BCR/ABL fusion protein isoform X9	BCR/ABL fusion	0.0292
5787	Angiopoietin-1 receptor	TEK	0.0292
6170	ATP-binding cassette sub-family A member 3	ABCA3	0.0292
4100	Gamma-aminobutyric-acid receptor subunit beta-2	GABRB2	0.0289
4099	Gamma-aminobutyric-acid receptor subunit beta-3	GABRB3	0.0286
146	Androgen receptor	AR	0.0283
841	Gamma-aminobutyric-acid receptor subunit alpha-6	GABRA6	0.0283
4177	Proto-oncogene tyrosine-protein kinase receptor ret	RET	0.0283
828	Phenylalanine-4-hydroxylase	PAH	0.0282
3109	Phenylalanine-4-hydroxylase	phhA	0.0282
380	Cytochrome P450 17A1	CYP17A1	0.0278
230	ATP-binding cassette transporter sub-family C member 8	ABCC8	0.0278
4137	Nociceptin receptor	OPRL1	0.0276
4604	Liver carboxylesterase 1	CES1	0.0275
40	RAF proto-oncogene serine/threonine-protein kinase	RAF1	0.0275
238	Peroxisome proliferator-activated receptor gamma	PPARG	0.0274
6181	UDP-glucuronosyltransferase 1-8	UGT1A8	0.0272
823	Fibroblast growth factor receptor 2	FGFR2	0.0268
610	Calcium-activated potassium channel subunit alpha 1	KCNMA1	0.0268
4120	NADPH--cytochrome P450 reductase	POR	0.026
1757	Myeloperoxidase	MPO	0.0259
458	Neuronal acetylcholine receptor subunit alpha-10	CHRNA10	0.0258
385	Potassium-transporting ATPase alpha chain 1	ATP4A	0.0257
464	Glutamate [NMDA] receptor subunit epsilon-2	GRIN2B	0.0256
6138	Multidrug resistance protein 3	ABCB4	0.0255
5798	Mitogen-activated protein kinase 11	MAPK11	0.0252
373	Transthyretin	TTR	0.0251
3804	Sodium channel protein type 4 subunit alpha	SCN4A	0.025
15	Voltage-dependent T-type calcium channel subunit alpha-1I	CACNA1I	0.0247
6141	Sodium/bile acid cotransporter	SLC10A1	0.0246
6148	Multidrug resistance-associated protein 7	ABCC10	0.0244
70	Type-1 angiotensin II receptor	AGTR1	0.0242
1284	Nuclear receptor subfamily 1 group I member 2	NR1I2	0.0242
734	D1 dopamine receptor-interacting protein calcyon	CALY	0.0241
811	Translocator protein	TSPO	0.0238
951	Macrophage colony-stimulating factor 1 receptor	CSF1R	0.0237
3854	Basic fibroblast growth factor receptor 1	FGFR1	0.0236
4113	Voltage-dependent L-type calcium channel subunit alpha-1F	CACNA1F	0.0236
3876	Aromatic-L-amino-acid decarboxylase	DDC	0.0235
756	Sex hormone-binding globulin	SHBG	0.0234
6086	Gamma-aminobutyric acid receptor subunit gamma-2	GABRG2	0.0234
750	Voltage-dependent calcium channel gamma-1 subunit	CACNG1	0.0234
439	Glutamate [NMDA] receptor subunit epsilon-4	GRIN2D	0.0231
777	Tumor necrosis factor	TNF	0.0231
158	Sodium channel protein type 1 subunit alpha	SCN1A	0.0228
6220	Aryl hydrocarbon receptor	AHR	0.0226
1360	Sphingomyelin phosphodiesterase	SMPD1	0.0224
614	Progesterone receptor	PGR	0.0223
6047	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	PDE1A	0.0218
1636	Trace amine-associated receptor 1	TAAR1	0.0218
6137	Multidrug resistance-associated protein 6	ABCC6	0.0217
837	Glutamate [NMDA] receptor subunit epsilon-1	GRIN2A	0.0217
6136	Multidrug resistance-associated protein 5	ABCC5	0.0217
1974	Oligopeptide transporter, kidney isoform	SLC15A2	0.0216
936	Ephrin type-A receptor 2	EPHA2	0.0214
723	Cytosolic phospholipase A2	PLA2G4A	0.0211
6093	Gamma-aminobutyric acid receptor subunit delta	GABRD	0.021
6087	Gamma-aminobutyric acid receptor subunit gamma-1	GABRG1	0.021
6089	Gamma-aminobutyric acid receptor subunit epsilon	GABRE	0.021
204	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE5A	0.0207
5692	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	PDE1B	0.0207
477	DNA topoisomerase 4 subunit A	parC	0.0205
886	DNA topoisomerase 4 subunit A	parC	0.0205
6226	DNA topoisomerase 4 subunit A	parC	0.0205
4098	Gamma-aminobutyric-acid receptor subunit beta-1	GABRB1	0.0203
567	Receptor tyrosine-protein kinase erbB-2	ERBB2	0.0203
869	Estrogen receptor beta	ESR2	0.0202
404	DNA gyrase subunit A	gyrA	0.0202
6224	DNA gyrase subunit A	gyrA	0.0202
147	Aldehyde dehydrogenase, mitochondrial	ALDH2	0.0202
6177	UDP-glucuronosyltransferase 1-10	UGT1A10	0.02
1341	Histamine H3 receptor	HRH3	0.0198
442	Envelope glycoprotein	gp41	0.0198
4859	Envelope glycoprotein	env	0.0198
2184	Cystic fibrosis transmembrane conductance regulator	CFTR	0.0195
392	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	CACNA1A	0.0194
16	Adenosine A1 receptor	ADORA1	0.0193
3810	Catechol O-methyltransferase	COMT	0.0193
183	Vascular endothelial growth factor A	VEGFA	0.0192
2981	Phospholipase A2, membrane associated	PLA2G2A	0.019
485	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	PDE3A	0.019
1010	Cytochrome P450 51A1	CYP51A1	0.0189
6088	Gamma-aminobutyric acid receptor subunit gamma-3	GABRG3	0.0187
6090	Gamma-aminobutyric acid receptor subunit pi	GABRP	0.0187
6092	Gamma-aminobutyric acid receptor subunit rho-2	GABRR2	0.0187
6115	Gamma-aminobutyric acid receptor subunit rho-3	GABRR3	0.0187
142	Gamma-aminobutyric-acid receptor subunit rho-1	GABRR1	0.0185
80	Peroxisome proliferator-activated receptor alpha	PPARA	0.0183
6020	Aldehyde oxidase	AOX1	0.0183
6079	Neuronal acetylcholine receptor subunit alpha-3	CHRNA3	0.0182
818	50S ribosomal protein L10	rplJ	0.0176
1178	Adenosine A2a receptor	ADORA2A	0.0176
5838	Transient receptor potential cation channel subfamily V member 3	TRPV3	0.0176
2162	Transient receptor potential cation channel subfamily M member 8	TRPM8	0.0176
1944	Transient receptor potential cation channel subfamily A member 1	TRPA1	0.0176
462	Intermediate conductance calcium-activated potassium channel protein 4	KCNN4	0.0175
161	Tubulin beta chain	TUBB	0.0174
312	Tubulin beta chain	TUB2	0.0174
3947	Xanthine dehydrogenase/oxidase	XDH	0.0172
164	Histamine H4 receptor	HRH4	0.0171
6023	Cytochrome P450 11B2, mitochondrial	CYP11B2	0.0171
921	Glutamate receptor 2	GRIA2	0.017
1389	Transforming growth factor beta-1	TGFB1	0.0169
516	Neurotensin receptor type 2	NTSR2	0.0168
6091	Gamma-aminobutyric acid receptor subunit theta	GABRQ	0.0168
389	Amiloride-sensitive cation channel 2, neuronal	ACCN2	0.0167
738	Monocarboxylate transporter 1	SLC16A1	0.0166
4095	Neuronal acetylcholine receptor subunit alpha-7	CHRNA7	0.0166
947	Neuronal acetylcholine receptor subunit alpha-4	CHRNA4	0.0166
3426	Glutamine synthetase	glnA	0.0164
3987	Glutamine synthetase	GLUL	0.0164
29	Tubulin beta-1 chain	TUBB1	0.0163
1291	cAMP response element-binding protein	CREB1	0.0163
6154	Multidrug and toxin extrusion protein 1	SLC47A1	0.0162
6014	Cytochrome P450 2A13	CYP2A13	0.0161
1995	Sodium channel protein type 9 subunit alpha	SCN9A	0.016
904	Glutathione S-transferase P	GSTP1	0.0157
6085	Fatty acid-binding protein, intestinal	FABP2	0.0157
1275	Estrogen sulfotransferase	SULT1E1	0.0155
4210	Toll-like receptor 4	TLR4	0.0154
737	Mineralocorticoid receptor	NR3C2	0.0153
952	Dipeptidyl peptidase 4	DPP4	0.0151
620	Bifunctional dihydrofolate reductase-thymidylate synthase	Not Available	0.015
232	Corticosteroid-binding globulin	SERPINA6	0.015
1050	Bile salt sulfotransferase	SULT2A1	0.0149
4112	Voltage-dependent L-type calcium channel subunit beta-4	CACNB4	0.0149
4114	Voltage-dependent L-type calcium channel subunit beta-3	CACNB3	0.0149
365	Dihydrofolate reductase	DHFR	0.0148
2381	Dihydrofolate reductase	DFR1	0.0148
2833	Dihydrofolate reductase	Not Available	0.0148
2931	Dihydrofolate reductase	folA	0.0148
3544	Dihydrofolate reductase	folA	0.0148
3682	Dihydrofolate reductase	folA	0.0148
6642	Dihydrofolate reductase	folA	0.0148
6756	Dihydrofolate reductase	dfrA	0.0148
215	Sodium channel protein type 11 subunit alpha	SCN11A	0.0147
6164	POU domain, class 5, transcription factor 1	POU5F1	0.0147
6541	Peptostreptococcal albumin-binding protein	pab	0.0142
427	Substance-P receptor	TACR1	0.0142
6169	ATP-binding cassette sub-family A member 5	ABCA5	0.0136
918	Glutamate receptor, ionotropic kainate 2	GRIK2	0.0135
1192	Sulfotransferase 1A1	SULT1A1	0.0135
333	Voltage-dependent L-type calcium channel subunit beta-1	CACNB1	0.0135
6150	Solute carrier organic anion transporter family member 4C1	SLCO4C1	0.0134
4148	Serine/threonine-protein kinase mTOR	MTOR	0.0134
709	ATP-sensitive inward rectifier potassium channel 1	KCNJ1	0.0134
541	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	PDE4B	0.0133
4116	Dihydropteroate synthetase	Not Available	0.0131
768	FK506-binding protein 1A	FKBP1A	0.013
3932	Glutathione S-transferase A2	GSTA2	0.013
4122	Histone deacetylase 2	HDAC2	0.0129
505	Glutamate [NMDA] receptor subunit epsilon-3	GRIN2C	0.0126
2183	Fatty acid-binding protein, adipocyte	FABP4	0.0124
295	Carbonic anhydrase 1	CA1	0.0124
591	Glutamate [NMDA] receptor subunit 3B	GRIN3B	0.0122
571	Melatonin receptor type 1A	MTNR1A	0.0122
362	Melatonin receptor type 1B	MTNR1B	0.0122
4160	Voltage-dependent calcium channel subunit alpha-2/delta-2	CACNA2D2	0.0122
6040	6-phosphogluconate dehydrogenase, decarboxylating	PGD	0.0121
778	Cysteinyl leukotriene receptor 1	CYSLTR1	0.012
592	Carbonic anhydrase 4	CA4	0.0116
4203	Histamine N-methyltransferase	HNMT	0.0115
2211	Fatty acid-binding protein, heart	FABP3	0.0114
4199	Sphingosine 1-phosphate receptor Edg-8	S1PR5	0.0113
6045	Voltage-dependent calcium channel subunit alpha-2/delta-3	CACNA2D3	0.0113
6151	Monocarboxylate transporter 10	SLC16A10	0.0106
613	Atrial natriuretic peptide receptor A	NPR1	0.0106
606	Cytochrome P450 27, mitochondrial	CYP27A1	0.0106
233	Potassium channel subfamily K member 2	KCNK2	0.0102
6153	Solute carrier organic anion transporter family member 4A1	SLCO4A1	0.0102
88	Retinoic acid receptor RXR-beta	RXRB	0.0102
6068	Guanylate cyclase soluble subunit alpha-2	GUCY1A2	0.0101
273	Apoptosis regulator Bcl-2	BCL2	0.0101
6070	Nischarin	NISCH	0.0099
2539	Tubulin alpha-1 chain	TUBA4A	0.0098
6038	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6H	0.0098
239	Coagulation factor X	F10	0.0097
958	Insulin-like growth factor 1 receptor	IGF1R	0.0097
2112	Toll-like receptor 9	TLR9	0.0097
357	Carbonic anhydrase 2	CA2	0.0096
5300	Antigen peptide transporter 1	TAP1	0.0096
1457	Long-chain-fatty-acid--CoA ligase 4	ACSL4	0.0096
2180	3-phosphoinositide-dependent protein kinase 1	PDPK1	0.0096
49	Endothelin B receptor	EDNRB	0.0096
3970	Voltage-dependent N-type calcium channel subunit alpha-1B	CACNA1B	0.0095
153	Dopamine beta-hydroxylase	DBH	0.0095
558	Solute carrier family 12 member 1	SLC12A1	0.0094
566	Serotransferrin	TF	0.0094
596	3-oxo-5-alpha-steroid 4-dehydrogenase 1	SRD5A1	0.0094
518	Peroxidase/catalase T	katG	0.0093
781	ATP-sensitive inward rectifier potassium channel 11	KCNJ11	0.0093
244	Angiotensin-converting enzyme	ACE	0.0092
6037	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6G	0.0092
1787	Nuclear factor NF-kappa-B p105 subunit	NFKB1	0.0092
24	Thymidylate synthase	TMP1	0.0091
359	Thymidylate synthase	TYMS	0.0091
2626	Thymidylate synthase	thyA	0.0091
2729	Thymidylate synthase	thyA	0.0091
5352	Thymidylate synthase	THYA	0.0091
578	Endothelin-1 receptor	EDNRA	0.009
814	Ryanodine receptor 1	RYR1	0.009
1353	DNA topoisomerase 1	TOP1	0.0089
3552	DNA topoisomerase 1	topA	0.0089
1971	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	PDE4A	0.0089
621	Periplasmic [Fe] hydrogenase 1	Not Available	0.0088
5251	Carbonyl reductase [NADPH] 1	CBR1	0.0088
2222	Equilibrative nucleoside transporter 1	SLC29A1	0.0088
780	Retinoic acid receptor RXR-gamma	RXRG	0.0088
165	FL cytokine receptor	FLT3	0.0088
259	Microsomal triglyceride transfer protein large subunit	MTTP	0.0087
4311	tRNA	TRDMT1	0.0087
4325	tRNA	trmD	0.0087
4328	tRNA	trmD	0.0087
4237	50S ribosomal protein L22	rplV	0.0087
563	Thyroid peroxidase	TPO	0.0086
3802	Sodium channel protein type 2 subunit alpha	SCN2A	0.0086
1561	Troponin C, slow skeletal and cardiac muscles	TNNC1	0.0084
6126	Carbonic anhydrase 7	CA7	0.0084
642	3-oxo-5-alpha-steroid 4-dehydrogenase 2	SRD5A2	0.0083
284	DNA-directed RNA polymerase beta chain	rpoB	0.0082
5773	DNA-directed RNA polymerase beta chain	rpoB	0.0082
1629	Transcription factor AP-1	JUN	0.0082
243	Ribosyldihydronicotinamide dehydrogenase [quinone]	NQO2	0.0081
139	Aldo-keto reductase family 1 member C1	AKR1C1	0.0081
565	Extracellular calcium-sensing receptor	CASR	0.008
208	DNA-directed RNA polymerase beta' chain	rpoC	0.008
5774	DNA-directed RNA polymerase beta' chain	rpoC	0.008
6525	Group IID secretory phospholipase A2	PLA2G2D	0.008
806	Sodium/potassium-transporting ATPase alpha-1 chain	ATP1A1	0.008
54	Prothrombin	F2	0.0079
173	Toll-like receptor 7	TLR7	0.0079
444	Alcohol dehydrogenase 1B	ADH1B	0.0079
459	Retinoic acid receptor RXR-alpha	RXRA	0.0078
645	Penicillin-binding protein 1A	mrcA	0.0078
5805	Penicillin-binding protein 1A	ponA	0.0078
6185	Penicillin-binding protein 1A	mrcA	0.0078
6799	Penicillin-binding protein 1A	pbpA	0.0078
2178	Metabotropic glutamate receptor 5	GRM5	0.0078
6179	UDP-glucuronosyltransferase 2B17	UGT2B17	0.0078
6043	Putative G-protein coupled receptor 44	GPR44	0.0078
2038	Inhibitor of nuclear factor kappa-B kinase subunit beta	IKBKB	0.0078
84	Nuclear receptor 0B1	NR0B1	0.0077
469	Annexin A1	ANXA1	0.0077
1638	Solute carrier family 2, facilitated glucose transporter member 2	SLC2A2	0.0077
251	Alcohol dehydrogenase 1A	ADH1A	0.0077
162	Retinoic acid receptor gamma-1	RARG	0.0076
650	Aldo-keto reductase family 1 member C3	AKR1C3	0.0076
2449	Tubulin alpha-3 chain	TUBA1A	0.0076
923	Glutamate receptor 3	GRIA3	0.0075
6152	Solute carrier organic anion transporter family member 2A1	SLCO2A1	0.0074
1541	Metalloproteinase	mmp20	0.0074
4238	50S ribosomal protein L4	rplD	0.0074
5578	50S ribosomal protein L4	rplD	0.0074
6173	50S ribosomal protein L4	rplD	0.0074
6219	50S ribosomal protein L4	rplD	0.0074
102	DNA topoisomerase I, mitochondrial	TOP1MT	0.0074
976	Platelet glycoprotein IX	GP9	0.0073
65	Matrix metalloproteinase-9	Not Available	0.0073
543	Penicillin-binding protein 1B	mrcB	0.0072
6186	Penicillin-binding protein 1B	ponB	0.0072
6822	Penicillin-binding protein 1b	pbp1b	0.0072
6844	Penicillin-binding protein 1b	pbp1b	0.0072
1992	Vitamin D-binding protein	GC	0.0072
1	Peptidoglycan synthetase ftsI	ftsI	0.0071
4155	Peptidoglycan synthetase ftsI	ftsI	0.0071
6174	50S ribosomal protein L32	rpmF	0.0071
856	Vitamin D3 receptor	VDR	0.0071
790	DNA polymerase subunit alpha B	POLA2	0.0071
990	Dual specificity mitogen-activated protein kinase kinase 1	MAP2K1	0.0071
6044	Serum paraoxonase/lactonase 3	PON3	0.0071
6155	ATP-binding cassette transporter sub-family C member 11	ABCC11	0.007
3809	Estrogen-related receptor gamma	ESRRG	0.007
594	Thyroxine-binding globulin	SERPINA7	0.007
1852	Microtubule-associated protein 2	MAP2	0.007
6146	High affinity copper uptake protein 1	SLC31A1	0.0069
6078	Neuronal acetylcholine receptor subunit beta-4	CHRNB4	0.0069
6206	DNA-directed RNA polymerase subunit beta'	rpoC	0.0069
200	Carnitine O-palmitoyltransferase 2, mitochondrial	CPT2	0.0069
451	Carnitine O-palmitoyltransferase I, liver isoform	CPT1A	0.0069
2853	14 kDa fatty acid-binding protein	Not Available	0.0068
634	Squalene monooxygenase	SQLE	0.0068
7196	Squalene monooxygenase	ERG1	0.0068
68	Cannabinoid receptor 1	CNR1	0.0068
3086	Plasmepsin-2	Not Available	0.0068
1483	Membrane copper amine oxidase	AOC3	0.0067
3937	Fatty-acid amide hydrolase	FAAH	0.0067
5934	Cytochrome P450 26A1	CYP26A1	0.0067
4103	Proteasome subunit beta type 2	PSMB2	0.0066
4102	Proteasome subunit beta type 5	PSMB5	0.0066
4101	Proteasome subunit beta type 1	PSMB1	0.0066
1502	Peroxisome proliferator-activated receptor delta	PPARD	0.0066
33	Cystine/glutamate transporter	SLC7A11	0.0066
3856	Fibroblast growth factor receptor 3	FGFR3	0.0066
6766	O-GlcNAcase BT_4395	BT_4395	0.0066
1630	Integrin beta-2	ITGB2	0.0066
2499	Tubulin beta-2C chain	TUBB2C	0.0065
581	Cytochrome P450 2R1	CYP2R1	0.0065
6149	Solute carrier family 22 member 10	SLC22A10	0.0065
758	Thyroid hormone receptor alpha	THRA	0.0064
7	Nitric oxide synthase, inducible	NOS2	0.0064
751	Potassium channel subfamily K member 6	KCNK6	0.0064
2157	NAD(P)H dehydrogenase [quinone] 1	NQO1	0.0064
1648	Elastin	ELN	0.0063
3432	Multidrug-efflux transporter 1 regulator	bmrR	0.0063
4476	Mannitol dehydrogenase	mtlD	0.0063
3601	Dihydropteroate synthase 1	folP1	0.0063
3807	Dihydropteroate synthase 1	folP1	0.0063
3808	Dihydropteroate synthase 2	folP2	0.0063
1119	Peroxiredoxin-5, mitochondrial	PRDX5	0.0063
1374	Natriuretic peptides B	NPPB	0.0063
1827	Gap junction alpha-1 protein	GJA1	0.0063
133	Dihydropterate synthase	sulI	0.0063
1908	Vascular cell adhesion protein 1	VCAM1	0.0063
280	4-aminobutyrate aminotransferase, mitochondrial	ABAT	0.0062
908	Glutathione S-transferase theta-1	GSTT1	0.0061
517	Alcohol dehydrogenase 1C	ADH1C	0.0061
6097	Protein S100-A2	S100A2	0.006
1810	Protein S100-A1	S100A1	0.006
6859	Protein S100-A4	S100A4	0.006
185	Vasopressin V1a receptor	AVPR1A	0.006
1196	Complement decay-accelerating factor	CD55	0.006
6103	Arylamine N-acetyltransferase 1	NAT1	0.0059
633	Penicillin-binding proteins 1A/1B	pbpA	0.0059
172	Potassium channel subfamily K member 1	KCNK1	0.0059
3382	Glycolipid transfer protein	GLTP	0.0058
368	Enoyl-[acyl-carrier-protein] reductase [NADH]	inhA	0.0058
3228	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0058
3678	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0058
6856	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0058
322	Vasopressin V2 receptor	AVPR2	0.0058
5880	Thrombopoietin receptor	MPL	0.0058
229	Retinoic acid receptor beta	RARB	0.0058
6270	Group IIE secretory phospholipase A2	PLA2G2E	0.0058
346	Thyroid hormone receptor beta-1	THRB	0.0058
6046	Voltage-gated calcium channel beta 1 subunit splice variant CavB1d	CACNB1	0.0057
73	Prostaglandin E2 receptor, EP1 subtype	PTGER1	0.0057
730	Retinoic acid receptor alpha	RARA	0.0057
4192	DNA topoisomerase 2-beta	TOP2B	0.0056
515	26S proteasome non-ATPase regulatory subunit 1	PSMD1	0.0055
522	26S proteasome non-ATPase regulatory subunit 2	PSMD2	0.0055
6506	Stathmin-4	STMN4	0.0055
3957	Adenosine deaminase	ADA	0.0055
992	Protein tyrosine kinase 2 beta	PTK2B	0.0054
3917	Methylenetetrahydrofolate reductase	MTHFR	0.0054
194	NADH dehydrogenase [ubiquinone] 1 subunit C2	NDUFC2	0.0053
390	Adenosine A3 receptor	ADORA3	0.0053
5998	Toll-like receptor 8	TLR8	0.0053
137	FolC bifunctional protein [Includes: Folylpolyglutamate synthase	folC	0.0052
6140	Ileal sodium/bile acid cotransporter	SLC10A2	0.0052
712	Tubulin alpha chain	TUB1	0.0052
2808	Chloramphenicol acetyltransferase 3	cat3	0.0052
3090	Chitosanase	csn	0.0052
1048	Protein S100-A13	S100A13	0.0052
4149	Nuclear factor NF-kappa-B p100 subunit	NFKB2	0.0052
2226	Protein S100-A12	S100A12	0.0052
66	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II	HSD3B2	0.0051
3913	Glutamic acid decarboxylase	GAD65	0.0051
3823	Cytokine receptor common gamma chain	IL2RG	0.0051
1525	Heparin-binding growth factor 2	FGF2	0.0051
2616	Ganglioside GM2 activator	GM2A	0.0051
2230	Catalase	CAT	0.005
3249	Catalase	katA	0.005
3625	Catalase	katA	0.005
4539	Catalase	katA	0.005
4941	Catalase	katB	0.005
6027	Alkaline phosphatase, tissue-nonspecific isozyme	ALPL	0.005
2207	Rhodopsin	RHO	0.0049
3404	Exotoxin A	eta	0.0049
2132	Protein S100-B	S100B	0.0049
6080	Neuronal acetylcholine receptor subunit alpha-5	CHRNA5	0.0049
6082	Neuronal acetylcholine receptor subunit beta-3	CHRNB3	0.0049
948	Neuronal acetylcholine receptor subunit beta-2	CHRNB2	0.0049
564	Cellular retinoic acid-binding protein 1	CRABP1	0.0048
6184	D-alanyl-D-alanine carboxypeptidase dacC	dacC	0.0048
5923	Microtubule-associated protein tau	MAPT	0.0048
5924	Microtubule-associated protein 4	MAP4	0.0048
360	Ribonucleoside-diphosphate reductase large subunit	RRM1	0.0048
364	Corticosteroid 11-beta-dehydrogenase isozyme 1	HSD11B1	0.0048
276	Sodium- and chloride-dependent GABA transporter 1	SLC6A1	0.0048
4773	Deoxycytidine kinase	DCK	0.0047
6677	Myelin P2 protein	PMP2	0.0047
2417	Chloramphenicol acetyltransferase	cat	0.0047
3278	Chloramphenicol acetyltransferase	cat	0.0047
859	Cellular retinoic acid-binding protein 2	CRABP2	0.0047
2810	Dr hemagglutinin structural subunit	draA	0.0047
683	Potassium transporter	GK0582	0.0047
1759	85 kDa calcium-independent phospholipase A2	PLA2G6	0.0046
1770	Phospholipase C	PLCL1	0.0046
2841	Phospholipase C	plc	0.0046
2718	Chloramphenicol 3-O phosphotransferase	Not Available	0.0046
1253	Interferon gamma	IFNG	0.0046
245	Large neutral amino acids transporter small subunit 1	SLC7A5	0.0046
4228	Keratin, type II cytoskeletal 7	KRT7	0.0046
4217	Telomerase reverse transcriptase	TERT	0.0046
199	Monocarboxylate transporter 8	SLC16A2	0.0046
6931	Calcium-activated potassium channel subunit beta-1	KCNMB1	0.0046
6933	Calcium-activated potassium channel subunit beta-4	KCNMB4	0.0046
6932	Calcium-activated potassium channel subunit beta-3	KCNMB3	0.0046
6934	Small conductance calcium-activated potassium channel protein 1	KCNN1	0.0046
6935	Small conductance calcium-activated potassium channel protein 2	KCNN2	0.0046
6936	Small conductance calcium-activated potassium channel protein 3	KCNN3	0.0046
527	Prostacyclin receptor	PTGIR	0.0045
6824	Tyrosine-protein kinase Lyn	LYN	0.0045
6081	Neuronal acetylcholine receptor subunit alpha-6	CHRNA6	0.0045
724	Interleukin-2 receptor alpha chain	IL2RA	0.0045
717	Interleukin-2 receptor subunit beta	IL2RB	0.0045
820	Glycine receptor subunit alpha-2	GLRA2	0.0045
4097	Neuronal acetylcholine receptor subunit alpha-9	CHRNA9	0.0045
115	Penicillin-binding protein 2	mrdA	0.0044
6069	Penicillin-binding protein 2	mrdA	0.0044
6118	Penicillin-binding protein 2	penA	0.0044
6187	Penicillin-binding protein 2	pbpA	0.0044
6686	Penicillin-binding protein 2	pbp2	0.0044
6939	Penicillin-binding protein 2	mrdA	0.0044
7163	Penicillin-binding protein 2	pbpA	0.0044
130	Prostacyclin synthase	PTGIS	0.0044
5645	DNA topoisomerase 4 subunit B	parE	0.0044
6227	DNA topoisomerase 4 subunit B	parE	0.0044
887	DNA gyrase subunit B	gyrB	0.0044
4150	DNA gyrase subunit B	gyrB	0.0044
6225	DNA gyrase subunit B	gyrB	0.0044
6033	High affinity interleukin-8 receptor A	CXCR1	0.0044
707	72 kDa type IV collagenase	MMP2	0.0044
117	Sterol O-acyltransferase 1	SOAT1	0.0043
5766	NAD-dependent deacetylase sirtuin-5	SIRT5	0.0043
937	Proto-oncogene tyrosine-protein kinase LCK	LCK	0.0043
735	Alanine aminotransferase 1	GPT	0.0043
3904	Alanine aminotransferase 2	GPT2	0.0043
473	L-lactate dehydrogenase A chain	LDHA	0.0042
714	Glutathione reductase, mitochondrial	GSR	0.0042
2450	Tyrosine-protein kinase ITK/TSK	ITK	0.0042
6459	Glycodelin	PAEP	0.0041
424	Dihydroorotate dehydrogenase, mitochondrial	DHODH	0.0041
3997	Cytochrome P450 24A1, mitochondrial	CYP24A1	0.0041
106	Cannabinoid receptor 2	CNR2	0.004
933	Proto-oncogene tyrosine-protein kinase Src	SRC	0.004
6032	PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE)	fas	0.004
5463	Calcium-activated potassium channel subunit beta 2	KCNMB2	0.004
6508	Putative uncharacterized protein	srtB	0.004
6543	Putative uncharacterized protein	tcp14	0.004
6615	Putative uncharacterized protein	MT0785	0.004
6623	Putative uncharacterized protein	Not Available	0.004
6806	Putative uncharacterized protein	AGR_C_2535	0.004
6813	Putative uncharacterized protein	SAV4671	0.004
6815	Putative uncharacterized protein	AFE_1514	0.004
6819	Putative uncharacterized protein	RUMGNA_03254	0.004
6825	Putative uncharacterized protein	CV_3270	0.004
4161	Furin	FURIN	0.004
268	Adenosine A2b receptor	ADORA2B	0.004
572	Integrin alpha-L	ITGAL	0.004
3868	Calcineurin subunit B isoform 2	PPP3R2	0.004
421	Calcium signal-modulating cyclophilin ligand	CAMLG	0.004
1714	Mitogen-activated protein kinase 3	MAPK3	0.004
1039	Histone deacetylase 9	HDAC9	0.0039
2290	ADP-ribosyl cyclase 2	BST1	0.0039
741	Potassium voltage-gated channel subfamily KQT member 1	KCNQ1	0.0039
3639	Thymidine phosphorylase	deoA	0.0039
3936	Thymidine phosphorylase	TYMP	0.0039
267	Plasminogen activator inhibitor 1	SERPINE1	0.0039
1768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit	GNG2	0.0039
1268	Neuropeptide S receptor	NPSR1	0.0039
1571	G protein-activated inward rectifier potassium channel 1	KCNJ3	0.0039
1129	C-C chemokine receptor type 5	CCR5	0.0039
1581	G protein-activated inward rectifier potassium channel 2	KCNJ6	0.0039
4209	ATP-sensitive inward rectifier potassium channel 8	KCNJ8	0.0038
6067	Penicillin binding protein 2a	mecA	0.0038
605	Fumarate reductase flavoprotein subunit	frdA	0.0038
2709	Fumarate reductase flavoprotein subunit	SO_0970	0.0038
3673	Fumarate reductase flavoprotein subunit	fccA	0.0038
4912	Fumarate reductase flavoprotein subunit	ifcA	0.0038
6549	Fumarate reductase flavoprotein subunit	frdA	0.0038
6048	Troponin C, skeletal muscle	TNNC2	0.0038
85	Growth hormone receptor	GHR	0.0038
1302	Dihydropyrimidine dehydrogenase [NADP+]	DPYD	0.0037
719	Retinoic acid receptor responder protein 1	RARRES1	0.0037
770	Retinoic acid-induced protein 3	GPRC5A	0.0037
2320	Thymidine kinase, cytosolic	TK1	0.0036
291	Nitric-oxide synthase, endothelial	NOS3	0.0036
1650	Heme carrier protein 1	SLC46A1	0.0036
3616	Fatty acid-binding protein, epidermal	FABP5	0.0036
5431	Lipid binding protein	Not Available	0.0036
5433	UPF0230 protein TM_1468	TM_1468	0.0036
5430	Hepatocyte nuclear factor 4-gamma	HNF4G	0.0036
819	Penicillin-binding protein 4	dacB	0.0036
2216	Fibroblast growth factor receptor 4	FGFR4	0.0035
4226	Uridine phosphorylase 2	UPP2	0.0035
2021	Thrombomodulin	THBD	0.0035
6221	Steroid hormone receptor ERR1	ESRRA	0.0035
6073	Potassium channel subfamily K member 9	KCNK9	0.0035
6072	Potassium channel subfamily K member 3	KCNK3	0.0035
2300	Lysozyme	E	0.0035
3633	Lysozyme	R	0.0035
5597	Lysozyme	17	0.0035
939	50S ribosomal protein L3	rplC	0.0035
6217	High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B	PDE8B	0.0035
3126	Poly [ADP-ribose] polymerase 1	PARP1	0.0034
182	2-oxoglutarate dehydrogenase E1 component, mitochondrial	OGDH	0.0034
6599	HTH-type transcriptional regulator ttgR	ttgR	0.0034
630	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial	ACADSB	0.0034
5432	Trafficking protein particle complex subunit 3	TRAPPC3	0.0033
569	Retinal dehydrogenase 2	ALDH1A2	0.0033
896	Glutathione S-transferase Mu 1	GSTM1	0.0033
4225	Uridine phosphorylase 1	UPP1	0.0033
6105	3-oxo-5-beta-steroid 4-dehydrogenase	AKR1D1	0.0032
838	Inosine-5'-monophosphate dehydrogenase 1	IMPDH1	0.0032
796	Inosine-5'-monophosphate dehydrogenase 2	IMPDH2	0.0032
1867	Major prion protein	PRNP	0.0032
6218	Pannexin-1	PANX1	0.0032
2107	Microtubule-associated protein 1A	MAP1A	0.0032
595	Fibrinogen alpha chain	FGA	0.0032
140	30S ribosomal protein S9	rpsI	0.0031
6719	30S ribosomal protein S9	rpsI	0.0031
6725	30S ribosomal protein S9	rpsI	0.0031
2298	Cytochrome P450-cam	camC	0.0031
1227	Cytochrome b	MT-CYB	0.0031
6386	Cytochrome b	petB	0.0031
6937	Cytochrome b	MT-CYB	0.0031
674	Dihydroorotate dehydrogenase homolog, mitochondrial	PFF0160c	0.0031
3760	Penicillin-binding protein 5 precursor	dacA	0.0031
6163	Copper-transporting ATPase 2	ATP7B	0.0031
6165	Copper-transporting ATPase 1	ATP7A	0.0031
611	Retinal dehydrogenase 1	ALDH1A1	0.0031
1524	Peptidyl-prolyl cis-trans isomerase A	PPIA	0.0031
6700	Peptidyl-prolyl cis-trans isomerase A	ppiA	0.0031
6216	High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A	PDE8A	0.003
2578	Tubulin beta-3 chain	TUBB3	0.003
413	Amidophosphoribosyltransferase	PPAT	0.003
2515	Amidophosphoribosyltransferase	purF	0.003
3714	Amidophosphoribosyltransferase	purF	0.003
2285	Streptogramin A acetyltransferase	vatD	0.003
489	Monocarboxylate transporter 2	SLC16A7	0.003
283	SEC14-like protein 2	SEC14L2	0.003
2599	Tyrosine-protein kinase HCK	HCK	0.003
3961	G protein-activated inward rectifier potassium channel 4	KCNJ5	0.003
3611	Cytidine deaminase	cdd	0.003
3707	Cytidine deaminase	cdd	0.003
4211	Cytidine deaminase	CDA	0.003
170	Succinate semialdehyde dehydrogenase, mitochondrial	ALDH5A1	0.0029
3813	Fibrinogen gamma chain	FGG	0.0029
3812	Fibrinogen beta chain [Contains: Fibrinopeptide B]	FGB	0.0029
691	cAMP-specific 3',5'-cyclic phosphodiesterase 7B	PDE7B	0.0029
4152	Superoxide dismutase [Cu-Zn]	SOD1	0.0029
512	DNA-directed RNA polymerase alpha chain	rpoA	0.0029
5772	DNA-directed RNA polymerase alpha chain	rpoA	0.0029
1435	Synaptic vesicle glycoprotein 2A	SV2A	0.0028
358	Cystathionine beta-synthase	CBS	0.0028
521	ATP-binding cassette transporter sub-family C member 9	ABCC9	0.0028
330	Spermidine synthase	SRM	0.0028
3038	Spermidine synthase	speE	0.0028
6207	30S ribosomal protein S14	rpsN	0.0028
6209	30S ribosomal protein S19	rpsS	0.0028
6712	30S ribosomal protein S19	rpsS	0.0028
6726	30S ribosomal protein S19	rpsS	0.0028
935	Proto-oncogene tyrosine-protein kinase Yes	YES1	0.0028
1063	Signal transducer and activator of transcription 5B	STAT5B	0.0028
1278	Pro-epidermal growth factor	EGF	0.0028
1200	AMBP protein	AMBP	0.0028
3866	Serum amyloid A protein	SAA1	0.0028
1932	Apolipoprotein E	APOE	0.0028
6232	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	GNAS	0.0027
6233	Adenylate cyclase type 2	ADCY2	0.0027
6234	Adenylate cyclase type 5	ADCY5	0.0027
1144	Hepatocyte growth factor receptor	MET	0.0027
4173	Tyrosine-protein kinase JAK2	JAK2	0.0027
2159	Quinone oxidoreductase	CRYZ	0.0027
6160	Solute carrier organic anion transporter family member 3A1	SLCO3A1	0.0027
6167	Organic solute transporter subunit beta	OSTB	0.0027
6166	Organic solute transporter subunit alpha	OSTA	0.0027
144	Hemoglobin subunit alpha	HBA1	0.0027
3849	Insulin-like growth factor-binding protein 7	IGFBP7	0.0027
2009	Protein NOV homolog	NOV	0.0027
3847	Neuroendocrine convertase 2	PCSK2	0.0027
1949	Carboxypeptidase E	CPE	0.0027
3850	Synaptotagmin-like protein 4	SYTL4	0.0027
3848	Neuroendocrine convertase 1	PCSK1	0.0027
3846	Retinoblastoma-associated protein	RB1	0.0027
889	3-oxoacyl-[acyl-carrier-protein] synthase 1	fabB	0.0027
6860	3-oxoacyl-[acyl-carrier-protein] synthase 1	kasA	0.0027
779	High-affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A	PDE7A	0.0026
293	Gamma-glutamyl hydrolase	GGH	0.0026
382	Glutamate receptor, ionotropic kainate 1	GRIK1	0.0026
132	ATP-binding cassette sub-family A member 1	ABCA1	0.0026
5997	Tumor necrosis factor ligand superfamily member 11	TNFSF11	0.0026
6123	Carbonic anhydrase 5A, mitochondrial	CA5A	0.0025
484	Tyrosine-protein kinase ABL2	ABL2	0.0025
1385	Angiotensin-converting enzyme 2	ACE2	0.0025
4252	Penicillin-binding protein 5	dacA	0.0025
3830	Calreticulin	CALR	0.0025
934	Proto-oncogene tyrosine-protein kinase Fyn	FYN	0.0024
3221	Cytochrome c4	cc4	0.0024
1792	Tissue-type plasminogen activator	PLAT	0.0024
334	S-adenosylmethionine synthetase isoform type-2	MAT2A	0.0024
544	Potassium voltage-gated channel subfamily E member 1	KCNE1	0.0024
159	Penicillin-binding protein 2B	penA	0.0024
6121	Penicillin-binding protein 2B	penA	0.0024
6039	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	PDE11A	0.0024
4109	cAMP-specific 3',5'-cyclic phosphodiesterase 4C	PDE4C	0.0024
6231	Pepsin A	PGA3	0.0024
5852	Type-2 angiotensin II receptor	AGTR2	0.0024
760	Fibroblast growth factor 1	FGF1	0.0024
6034	Hydroxyindole O-methyltransferase	ASMT	0.0023
6035	Nuclear receptor ROR-beta	RORB	0.0023
6036	Eosinophil peroxidase	EPX	0.0023
4221	Vascular endothelial growth factor	VEGF	0.0023
5816	Cadherin-5	CDH5	0.0023
332	Beta-lactamase	blaZ	0.0023
2478	Beta-lactamase	ampC	0.0023
2613	Beta-lactamase	ampC	0.0023
2635	Beta-lactamase	ampC	0.0023
2700	Beta-lactamase	penP	0.0023
5445	Beta-lactamase	blaB	0.0023
6019	Beta-lactamase	SHV-7	0.0023
6701	Beta-lactamase	cphA	0.0023
550	Amiloride-sensitive sodium channel subunit delta	SCNN1D	0.0023
27	Amiloride-sensitive sodium channel subunit beta	SCNN1B	0.0023
552	Amiloride-sensitive sodium channel subunit gamma	SCNN1G	0.0023
213	Amiloride-sensitive sodium channel subunit alpha	SCNN1A	0.0023
1830	5'-nucleotidase	NT5E	0.0023
453	S-adenosylmethionine synthetase isoform type-1	MAT1A	0.0023
6501	Fatty acid-binding protein, liver	FABP1	0.0023
6131	Carbonic anhydrase 14	CA14	0.0023
113	S-adenosylmethionine decarboxylase proenzyme	AMD1	0.0022
686	Aldo-keto reductase family 1 member C2	AKR1C2	0.0022
695	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	PDE10A	0.0022
411	Glycine N-methyltransferase	GNMT	0.0022
2155	Insulin-degrading enzyme	IDE	0.0022
2232	Interleukin-5	IL5	0.0022
298	Renin	REN	0.0021
1593	Mucin-2	MUC2	0.0021
6122	Carbonic anhydrase 3	CA3	0.0021
2091	Endoplasmin	HSP90B1	0.0021
6211	Tubulin epsilon chain	TUBE1	0.0021
6212	Tubulin gamma-1 chain	TUBG1	0.0021
6210	Tubulin delta chain	TUBD1	0.0021
1244	Low-density lipoprotein receptor-related protein 2	LRP2	0.0021
63	Malate dehydrogenase	mdh	0.0021
2329	Malate dehydrogenase	mdh	0.0021
3445	Malate dehydrogenase	mdh	0.0021
4420	Malate dehydrogenase	mdh	0.0021
4438	Malate dehydrogenase	mdh	0.0021
331	Retinol-binding protein I, cellular	RBP1	0.0021
400	Coagulation factor IX	F9	0.0021
5461	Coagulation factor IX	F9	0.0021
748	5'-AMP-activated protein kinase catalytic subunit alpha-1	PRKAA1	0.002
765	Indoleamine 2,3-dioxygenase	IDO1	0.002
6042	Prostaglandin reductase 2	PTGR2	0.002
6893	Calcium/calmodulin-dependent protein kinase type II gamma chain	CAMK2G	0.002
1820	Beta-nerve growth factor	NGF	0.002
6755	Poliovirus receptor	PVR	0.002
822	Aldose reductase	AKR1B1	0.002
6172	ATP-binding cassette sub-family B member 8, mitochondrial	ABCB8	0.0019
2236	Casein kinase II subunit alpha	CSNK2A1	0.0019
2358	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	PDE4D	0.0019
718	Folate receptor gamma	FOLR3	0.0019
299	Folate receptor beta	FOLR2	0.0019
804	Mitochondrial folate transporter/carrier	SLC25A32	0.0019
461	Glycine receptor subunit alpha-3	GLRA3	0.0019
217	Estradiol 17-beta-dehydrogenase 1	HSD17B1	0.0019
4081	Vitamin K epoxide reductase complex subunit 1-like protein 1	VKORC1L1	0.0019
604	Vitamin K-dependent protein Z	PROZ	0.0019
893	[Citrate [pro-3S]-lyase] ligase	citC	0.0018
845	Pyruvate dehydrogenase [cytochrome]	poxB	0.0018
5626	Nucleoside diphosphate kinase B	NME2	0.0018
1968	ATP-sensitive inward rectifier potassium channel 12	KCNJ12	0.0018
327	Glutathione reductase	gor	0.0018
5110	Glutathione reductase	GR2	0.0018
3312	Fatty acid-binding protein, brain	FABP7	0.0018
1198	Serum paraoxonase/arylesterase 1	PON1	0.0018
6223	Penicillin-binding protein 1C	pbpC	0.0018
1123	Eosinophil cationic protein	RNASE3	0.0018
67	Prolyl 4-hydroxylase subunit alpha-1	P4HA1	0.0017
422	Vitamin K-dependent protein C	PROC	0.0017
1245	Vitamin K-dependent protein S	PROS1	0.0017
6161	Probable low affinity copper uptake protein 2	SLC31A2	0.0017
214	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	NDUFS3	0.0017
337	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial	NDUFS7	0.0017
803	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	NDUFS2	0.0017
6168	Solute carrier family 22 member 16	SLC22A16	0.0017
6124	Carbonic anhydrase 5B, mitochondrial	CA5B	0.0017
6836	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial	HIBCH	0.0016
6837	Serine/threonine-protein kinase 17B	STK17B	0.0016
78	Acetyl-CoA acetyltransferase, mitochondrial	ACAT1	0.0016
6861	Alcohol dehydrogenase [NADP+]	AKR1A1	0.0016
6228	Nuclear receptor coactivator 1	NCOA1	0.0016
1243	Cathepsin D	CTSD	0.0016
2404	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PIK3CG	0.0016
890	Niemann-Pick C1-like protein 1	NPC1L1	0.0016
2297	Genome polyprotein	Not Available	0.0016
2322	Genome polyprotein	Not Available	0.0016
2694	Genome polyprotein	Not Available	0.0016
2719	Genome polyprotein	Not Available	0.0016
2860	Genome polyprotein	Not Available	0.0016
2928	Genome polyprotein	Not Available	0.0016
3160	Genome polyprotein	Not Available	0.0016
3260	Genome polyprotein	Not Available	0.0016
4783	Genome polyprotein	Not Available	0.0016
5726	Genome polyprotein	Not Available	0.0016
5779	Genome polyprotein	Not Available	0.0016
5867	Genome polyprotein	Not Available	0.0016
6253	Genome polyprotein	Not Available	0.0016
6301	Genome polyprotein	Not Available	0.0016
6380	Genome polyprotein	Not Available	0.0016
6381	Genome polyprotein	Not Available	0.0016
6437	Genome polyprotein	Not Available	0.0016
6520	Genome polyprotein	Not Available	0.0016
6521	Genome polyprotein	Not Available	0.0016
6652	Genome polyprotein	Not Available	0.0016
6734	Genome polyprotein	Not Available	0.0016
6735	Genome polyprotein	Not Available	0.0016
6736	Genome polyprotein	Not Available	0.0016
6737	Genome polyprotein	Not Available	0.0016
6738	Genome polyprotein	Not Available	0.0016
6739	Genome polyprotein	Not Available	0.0016
6744	Genome polyprotein	Not Available	0.0016
6748	Genome polyprotein	Not Available	0.0016
6894	Genome polyprotein	Not Available	0.0016
6898	Genome polyprotein	Not Available	0.0016
1313	Lactoylglutathione lyase	GLO1	0.0016
3238	Multidrug resistance protein mexA	mexA	0.0016
3709	Glycerol uptake facilitator protein	glpF	0.0016
3116	Bacterioferritin	bfr	0.0016
4906	Bacterioferritin	bfr	0.0016
4965	Bacterioferritin	bfr	0.0016
5489	Ribonucleoside-diphosphate reductase 1 subunit beta	nrdB	0.0016
3173	Enolase	eno	0.0016
3336	C4-dicarboxylate transport transcriptional regulatory protein dctD	dctD	0.0016
3393	TGF-beta receptor type-2	TGFBR2	0.0016
3233	Bile acid receptor	NR1H4	0.0015
2408	Tyrosine-protein kinase SYK	SYK	0.0015
76	Nitric-oxide synthase, brain	NOS1	0.0015
448	Vitamin K-dependent gamma-carboxylase	GGCX	0.0015
702	UMP-CMP kinase	CMPK1	0.0015
982	Cocaine- and amphetamine-regulated transcript protein	CARTPT	0.0015
3844	HLA class II histocompatibility antigen, DQ(6) alpha chain	HLA-DQA2	0.0015
1939	Heat shock protein HSP 90-alpha	HSP90AA1	0.0015
5294	Nucleoside diphosphate kinase A	NME1	0.0015
1569	G1/S-specific cyclin-D1	CCND1	0.0015
6656	UDP-glucuronosyltransferase 3A1	UGT3A1	0.0014
6316	ADP-ribosylation factor 1	ARF1	0.0014
2347	Proto-oncogene serine/threonine-protein kinase Pim-1	PIM1	0.0014
476	RAC-alpha serine/threonine-protein kinase	AKT1	0.0014
4948	Cytochrome c-553	Not Available	0.0014
4923	Cytochrome c3	DvMF_2499	0.0014
4945	Cytochrome c3	Not Available	0.0014
4949	Cytochrome c3	DVU_3171	0.0014
4968	Cytochrome c3	cytc3	0.0014
4997	Cytochrome c3	SO_2727	0.0014
5219	Cytochrome c3	cyd	0.0014
4902	Nine-heme cytochrome c	Ddes_2038	0.0014
3189	High-molecular-weight cytochrome c	hmcA	0.0014
1760	Aminopeptidase N	ANPEP	0.0014
6843	Aminopeptidase N	pepN	0.0014
798	Osteocalcin	BGLAP	0.0014
2852	DNA mismatch repair protein mutL	mutL	0.0014
3007	Carbonic anhydrase 12	CA12	0.0014
4205	Carbonic anhydrase 9	CA9	0.0014
5278	Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1	PAPSS1	0.0013
3191	Histidinol dehydrogenase	hisD	0.0013
6241	Nuclear receptor coactivator 2	NCOA2	0.0013
369	Coagulation factor VII	F7	0.0013
860	Nicotinamide N-methyltransferase	NNMT	0.0013
699	Nicotinic acid receptor 1	GPR109A	0.0013
928	Nicotinic acid receptor 2	GPR109B	0.0013
583	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	QPRT	0.0013
2442	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	nadC	0.0013
2459	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	nadC	0.0013
1405	Thiopurine S-methyltransferase	TPMT	0.0013
6116	Gastric triacylglycerol lipase	LIPF	0.0012
3806	cGMP-dependent 3',5'-cyclic phosphodiesterase	PDE2A	0.0012
4692	A/G-specific adenine glycosylase	mutY	0.0012
694	Matrix protein 2	M	0.0012
2240	Cell division protein kinase 2	CDK2	0.0012
4386	Hemoglobin-like protein HbN	glbN	0.0012
338	DNA polymerase	UL30	0.0012
379	DNA polymerase	UL54	0.0012
697	DNA polymerase	ORF28	0.0012
2482	DNA polymerase	43	0.0012
4104	DNA polymerase	BALF5	0.0012
1295	Fatty acid synthase	FASN	0.0012
6344	ATP synthase subunit gamma, mitochondrial	ATP5C1	0.0012
6343	ATP synthase subunit beta, mitochondrial	ATP5B	0.0012
6342	ATP synthase subunit alpha, mitochondrial	ATP5A1	0.0012
3610	Thioredoxin reductase 1, cytoplasmic	TXNRD1	0.0012
754	Pancreatic triacylglycerol lipase	PNLIP	0.0011
4954	Soluble cytochrome b558	Not Available	0.0011
4916	Cyanoglobin	glbN	0.0011
4943	Cytochrome c6	petJ	0.0011
4925	Cytochrome c-type protein SHP	shp	0.0011
4947	Bacterial hemoglobin	vhb	0.0011
4915	Cytochrome c-550	psbV	0.0011
4959	Cytochrome c-550	psbV	0.0011
5216	Cytochrome c-550	psbV	0.0011
4994	Hemoglobin-like protein HbO	glbO	0.0011
4975	Cytochrome c-556	RPA3973	0.0011
4934	Cytochrome c-551	nirM	0.0011
5218	Cytochrome c-551	nirM	0.0011
4984	Neuroglobin	NGB	0.0011
5000	HemO	hemO	0.0011
4936	Cytochrome c2 iso-2	Not Available	0.0011
4905	Cytochrome c2	Not Available	0.0011
4939	Cytochrome c2	cycA	0.0011
4964	Cytochrome c2	cycA	0.0011
4979	Cytochrome c2	cycA	0.0011
6673	Cytochrome c2	cycA	0.0011
4981	Iron-starvation protein PigA	pigA	0.0011
4942	Diheme cytochrome c napB	napB	0.0011
4998	Hemoglobin-like protein yjbI	yjbI	0.0011
4910	Cytoglobin	CYGB	0.0011
4909	CooA protein	cooA	0.0011
4935	Cytochrome c-554	cycA1	0.0011
4961	Hemophore HasA	hasA	0.0011
644	Heme oxygenase 2	HMOX2	0.0011
4982	Heme oxygenase 2	pbsA2	0.0011
4907	Cytochrome c-L	moxG	0.0011
6865	Cytochrome c-L	moxG	0.0011
4971	Nonaheme cytochrome c	hmcA	0.0011
4904	Cytochrome c family protein	GSU1996	0.0011
4976	Apocytochrome f	petA	0.0011
6407	Apocytochrome f	petA	0.0011
4931	Cytochrome P450 167A1	CYP167A1	0.0011
4937	Cytochrome oxidase subunit II	rcoxA	0.0011
4989	Cytochrome c551 peroxidase	ccp	0.0011
5222	Cytochrome c551 peroxidase	ccpA	0.0011
4764	Cytochrome P450 165C4	CYP165C4	0.0011
4999	Cytochrome P450 165B3	CYP165B3	0.0011
4903	Methyl-accepting chemotaxis protein	Tar4	0.0011
4960	Putative cytochrome P450-family protein	SCO7417	0.0011
4972	P450cin	cinA	0.0011
4926	Heme-based aerotactic transducer hemAT	hemAT	0.0011
4970	Cytochrome c nitrite reductase catalytic subunit	nrfA	0.0011
4922	Cytochrome c, putative	SO_4144	0.0011
4993	Hydroxylamine oxidoreductase	hao1	0.0011
4952	Catalase/peroxidase	katA	0.0011
4908	Heme-regulated cyclic AMP phosphodiesterase	dosP	0.0011
3093	Catalase HPII	katE	0.0011
5818	Folate receptor alpha	FOLR1	0.0011
2802	Endoglucanase G	celCCG	0.0011
6259	(3R)-hydroxymyristoyl-acyl carrier protein dehydratase	fabZ	0.001
2461	D-alanyl-D-alanine carboxypeptidase	Not Available	0.001
5756	D-alanyl-D-alanine carboxypeptidase	dac	0.001
493	25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	CYP27B1	0.001
2101	Glutathione-requiring prostaglandin D synthase	HPGDS	0.001
4041	Microsomal glutathione S-transferase 2	MGST2	0.001
1176	Mitogen-activated protein kinase 1	MAPK1	0.001
2473	Tyrosine-protein kinase CSK	CSK	0.001
2398	Tyrosine-protein kinase ZAP-70	ZAP70	0.001
2268	Cholesterol oxidase	choB	0.0009
2822	Cholesterol oxidase	choA	0.0009
997	Protein kinase C beta type	PRKCB	0.0009
1507	Cytochrome c	CYCS	0.0009
1064	DNA (cytosine-5)-methyltransferase 1	DNMT1	0.0009
2283	Steroid Delta-isomerase	ksi	0.0009
2920	Steroid Delta-isomerase	ksi	0.0009
1970	Protein kinase C alpha type	PRKCA	0.0009
6171	Solute carrier family 28 member 3	SLC28A3	0.0009
773	Folylpolyglutamate synthase, mitochondrial	FPGS	0.0009
22	30S ribosomal protein S4	rpsD	0.0008
6714	30S ribosomal protein S4	rpsD	0.0008
6263	cAMP-dependent protein kinase catalytic subunit alpha	PRKACA	0.0008
2325	Sulfotransferase family cytosolic 2B member 1	SULT2B1	0.0008
4920	Peroxidase/catalase	katG	0.0008
2119	Cytochrome b5	CYB5A	0.0008
4990	PpcA	ppcA	0.0008
4956	Quinohemoprotein alcohol dehydrogenase ADH IIB	qbdA	0.0008
3375	Acidic cytochrome c3	Not Available	0.0008
4988	Sulfite oxidase, mitochondrial	SUOX	0.0008
2915	Sensor protein fixL	fixL	0.0008
4944	Sensor protein fixL	fixL	0.0008
3570	Cytochrome P450 152A1	cypC	0.0008
4037	Hypothetical protein	GPX1	0.0008
4297	Hypothetical protein	SP_1951	0.0008
4521	Hypothetical protein	BC_2969	0.0008
4540	Hypothetical protein	TM_1070	0.0008
4555	Hypothetical protein	MT1739	0.0008
4569	Hypothetical protein	mshD	0.0008
4578	Hypothetical protein	PA3270	0.0008
4747	Hypothetical protein	PA3967	0.0008
5177	Hypothetical protein	TM_0096	0.0008
5194	Hypothetical protein	PA1204	0.0008
5240	Hypothetical protein	Rv2991	0.0008
5370	Hypothetical protein	TM_1158	0.0008
5710	Hypothetical protein	Tb927.5.1360	0.0008
4385	Cytochrome c'	Not Available	0.0008
4967	Cytochrome c'	cycA	0.0008
5038	Cytochrome c'	Not Available	0.0008
5223	Cytochrome c'	cycP	0.0008
4813	Heme oxygenase	hmuO	0.0008
5769	Heme oxygenase	Not Available	0.0008
4289	Cytochrome P450	TT_P0059	0.0008
6262	Cytochrome P450	staP	0.0008
4992	Cytochrome c peroxidase	Not Available	0.0008
4031	Glutathione S-transferase A1	GSTA1	0.0008
500	Monocarboxylate transporter 4	SLC16A3	0.0008
2287	Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase	ATIC	0.0008
1649	Small inducible cytokine A2	CCL2	0.0008
2530	Protein kinase C theta type	PRKCQ	0.0008
1025	Aquaporin-1	AQP1	0.0008
866	Large neutral amino acids transporter small subunit 2	SLC7A8	0.0007
3411	Cytochrome P450 121	cyp121	0.0007
3670	Soluble cytochrome b562 precursor	cybC	0.0007
3291	Cytochrome c-552	cycA	0.0007
4927	Cytochrome c-552	nrfA	0.0007
4938	Cytochrome c-552	cycA	0.0007
4953	Cytochrome c-552	nrfA	0.0007
5217	Cytochrome c-552	cycM	0.0007
2617	Nitric oxide synthase oxygenase	nos	0.0007
2701	Nitric oxide synthase oxygenase	nos	0.0007
3102	Flavohemoprotein	hmp	0.0007
4969	Flavohemoprotein	hmp	0.0007
6134	Sodium channel subunit beta-3	SCN3B	0.0007
6133	Sodium channel subunit beta-2	SCN2B	0.0007
6135	Sodium channel subunit beta-4	SCN4B	0.0007
6132	Sodium channel subunit beta-1	SCN1B	0.0007
6129	Carbonic anhydrase-related protein 11	CA11	0.0007
6127	Carbonic anhydrase-related protein	CA8	0.0007
6128	Carbonic anhydrase-related protein 10	CA10	0.0007
3587	Gastrotropin	FABP6	0.0007
2511	MAP kinase-activated protein kinase 2	MAPKAPK2	0.0007
226	Gonadotropin-releasing hormone receptor	GNRHR	0.0007
125	DNA polymerase beta	POLB	0.0007
2845	Bifunctional P-450:NADPH-P450 reductase	CYP102A1	0.0006
2972	6-deoxyerythronolide B hydroxylase	eryF	0.0006
342	P protein [Includes: DNA-directed DNA polymerase	P	0.0006
612	P protein [Includes: DNA-directed DNA polymerase	P	0.0006
3803	Sodium channel protein type 3 subunit alpha	SCN3A	0.0006
6130	Carbonic anhydrase 13	CA13	0.0006
677	Choline-phosphate cytidylyltransferase A	PCYT1A	0.0006
4608	Putative cytochrome P450	SCO1207	0.0006
4963	Putative cytochrome P450	SCO2884	0.0006
6254	Putative cytochrome P450	SCO6998	0.0006
5221	Cytochrome c3, 13 kDa	Not Available	0.0006
3152	Cytochrome c''	cycA	0.0006
5220	Split-Soret cytochrome c	Ddes_2150	0.0006
3700	Cytochrome c-552 precursor	nrfA	0.0006
1721	Glycogen synthase kinase-3 beta	GSK3B	0.0005
693	Hemoglobin subunit beta	HBB	0.0005
6743	Non-fluorescent flavoprotein	luxF	0.0005
6753	Apolipoprotein M	APOM	0.0005
2528	Fatty acid metabolism regulator protein	fadR	0.0005
6740	Fatty acid metabolism regulator protein	fadR	0.0005
6752	Guanylyl cyclase-activating protein 1	GUCA1A	0.0005
394	Calcineurin subunit B isoform 1	PPP3R1	0.0005
6742	Recoverin	RCVRN	0.0005
6747	Chalcone/stilbene synthase family protein	MT1417	0.0005
6741	Peroxisomal 3,2-trans-enoyl-CoA isomerase	PECI	0.0005
6522	Hepatocyte nuclear factor 4-alpha	HNF4A	0.0005
6751	Gag polyprotein	gag	0.0005
6746	Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	PPP3CA	0.0005
6749	Polyprotein	Not Available	0.0005
6268	Hydroxyacid oxidase 1	HAO1	0.0005
810	Heme oxygenase 1	HMOX1	0.0005
3391	Heme oxygenase 1	pbsA1	0.0005
3127	Nitrite reductase	nirS	0.0005
3284	Nitrite reductase	nirS	0.0005
5961	Insulin	INS	0.0005
6002	Prostaglandin E2 receptor EP4 subtype	PTGER4	0.0005
6527	Lymphocyte antigen 96	LY96	0.0005
4131	Prostaglandin E2 receptor, EP3 subtype	PTGER3	0.0004
406	Prostaglandin E2 receptor, EP2 subtype	PTGER2	0.0004
3405	Quinohaemoprotein ethanol dehydrogenase type-1	qheDH	0.0004
6750	ADP-ribosylation factor 6	ARF6	0.0004
4373	Medium-chain-fatty-acid--CoA ligase	Not Available	0.0004
6524	Protein tonB	tonB	0.0004
2435	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase	lpxC	0.0004
6613	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase	lpxC	0.0004
340	Apoptotic protease-activating factor 1	APAF1	0.0004
2391	Ferrochelatase	hemH	0.0004
6502	Ferrochelatase	DKFZp686P18130	0.0004
1591	Ferrochelatase, mitochondrial	FECH	0.0004
864	Gag-Pol polyprotein	gag-pol	0.0003
2237	Gag-Pol polyprotein	gag-pol	0.0003
2326	Gag-Pol polyprotein	gag-pol	0.0003
2451	Gag-Pol polyprotein	gag-pol	0.0003
2901	Gag-Pol polyprotein	gag-pol	0.0003
3165	Gag-Pol polyprotein	gag-pol	0.0003
3722	Gag-Pol polyprotein	gag-pol	0.0003
6306	Gag-Pol polyprotein	gag-pol	0.0003
6624	Gag-Pol polyprotein	gag-pol	0.0003
825	Arsenical pump-driving ATPase	ASNA1	0.0003
3435	Arsenical pump-driving ATPase	arsA	0.0003
486	Serine/threonine-protein kinase ALS2CR7	CDK15	0.0003
2105	ATP-binding cassette sub-family G member 1	ABCG1	0.0003
377	Beta-adrenergic receptor kinase 1	ADRBK1	0.0003
510	Serine/threonine-protein kinase receptor R3	ACVRL1	0.0003
733	Activin receptor type 1B	ACVR1B	0.0003
225	NEDD8-activating enzyme E1 regulatory subunit	NAE1	0.0003
745	Anti-Muellerian hormone type-2 receptor	AMHR2	0.0003
483	A-Raf proto-oncogene serine/threonine-protein kinase	ARAF	0.0003
21	Beta-adrenergic receptor kinase 2	ADRBK2	0.0003
154	AFG3-like protein 2	AFG3L2	0.0003
395	ALK tyrosine kinase receptor	Not Available	0.0003
6496	Cytochrome c oxidase subunit 8A, mitochondrial	COX8A	0.0003
6493	Cytochrome c oxidase subunit 6C	COX6C	0.0003
6495	Cytochrome c oxidase subunit 7C, mitochondrial	COX7C	0.0003
6499	Cytochrome c oxidase polypeptide 7A1, mitochondrial	COX7A1	0.0003
6494	Cytochrome c oxidase subunit 7B, mitochondrial	COX7B	0.0003
6491	Cytochrome c oxidase subunit 5A, mitochondrial	COX5A	0.0003
6498	Cytochrome c oxidase subunit 6B1	COX6B1	0.0003
6497	Cytochrome c oxidase subunit 6A2, mitochondrial	COX6A2	0.0003
6489	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	COX4I1	0.0003
5793	Cytochrome c oxidase subunit 2	MT-CO2	0.0003
6559	Cytochrome c oxidase subunit 2	ctaC	0.0003
6669	Cytochrome c oxidase subunit 2	ctaC	0.0003
6490	Cytochrome c oxidase subunit 3	MT-CO3	0.0003
371	Cytochrome c oxidase subunit 1	MT-CO1	0.0003
6558	Cytochrome c oxidase subunit 1	ctaD	0.0003
292	Activin receptor type-1	ACVR1	0.0003
849	Activated CDC42 kinase 1	TNK2	0.0003
2540	Choloylglycine hydrolase	cbh	0.0003
2427	Ferrichrome-iron receptor	fhuA	0.0003
704	Long-chain-fatty-acid--CoA ligase 1	ACSL1	0.0003
821	Acetyl-coenzyme A synthetase 2-like, mitochondrial	ACSS1	0.0003
386	Acetyl-coenzyme A synthetase, cytoplasmic	ACSS2	0.0003
297	Adenylate cyclase type 1	ADCY1	0.0003
289	Cytosolic purine 5'-nucleotidase	NT5C2	0.0003
6264	cAMP-dependent protein kinase inhibitor alpha	PKIA	0.0003
740	Argininosuccinate synthase	ASS1	0.0002
865	Argininosuccinate synthase	ASS1	0.0002
2680	Argininosuccinate synthase	argG	0.0002
3194	Argininosuccinate synthase	argG	0.0002
661	ADP/ATP translocase 1	SLC25A4	0.0002
6021	Adenosine kinase	ADK	0.0002
242	Asparagine synthetase [glutamine-hydrolyzing]	ASNS	0.0002
6500	Phospholipase A2	PLA2G1B	0.0002

(*) Categorization taken from DrugBank: therapeutic category or general category of a drug (i.e. anti-convulsant, antibacterial, etc.)

DB00321 - Amitriptyline

Targets

Enzymes

Transporters

Carriers

Predictions