DT-Web

DB00368 - Norepinephrine


Identification
Name Norepinephrine
Accession Number DB00368 (APRD01299)
Type small molecule
Description Precursor of epinephrine that is secreted by the adrenal medulla and is a widespread central and autonomic neurotransmitter. Norepinephrine is the principal transmitter of most postganglionic sympathetic fibers and of the diffuse projection system in the brain arising from the locus ceruleus. It is also found in plants and is used pharmacologically as a sympathomimetic. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 169.1778
Groups approved
Monoisotopic Weight 169.073893223
Pharmacology
Indication Mainly used to treat patients in vasodilatory shock states such as septic shock and neurogenic shock and has shown a survival benefit over dopamine. Also used as a vasopressor medication for patients with critical hypotension.
Mechanism of action Norepinephrine functions as a peripheral vasoconstrictor by acting on alpha-adrenergic receptors. It is also an inotropic stimulator of the heart and dilator of coronary arteries as a result of it's activity at the beta-adrenergic receptors.
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity In high dose and especially when it is combined with other vasopressors, it can lead to limb ischemia and limb death.
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Amitriptyline The tricyclic antidepressant, amitriptyline, increases the sympathomimetic effect of norepinephrine.
Amoxapine The tricyclic antidepressant, amoxapine, increases the sympathomimetic effect of norepinephrine.
Clomipramine The tricyclic antidepressant, clomipramine, increases the sympathomimetic effect of norepinephrine.
Desipramine The tricyclic antidepressant, desipramine, increases the sympathomimetic effect of norepinephrine.
Desvenlafaxine Desvenlafaxine may increase the tachycardic and vasopressor effects of norepinephrine. Consider alternate therapy or monitor for increased sympathomimetic effects, such as increased blood pressure, chest pain and headache.
Doxepin The tricyclic antidepressant, doxepin, increases the sympathomimetic effect of norepinephrine.
Entacapone Entacapone increases the effect and toxicity of the sympathomimetic, norepinephrine.
Guanethidine Norepinephrine may decrease the effect of guanethidine.
Imipramine The tricyclic antidepressant, imipramine, increases the sympathomimetic effect of norepinephrine.
Isocarboxazid Increased arterial pressure
Linezolid Possible increase of arterial pressure
Methyldopa Increased arterial pressure
Midodrine Increased arterial pressure
Moclobemide Moclobemide increases the sympathomimetic effect of norepinephrine.
Nortriptyline The tricyclic antidepressant, nortriptyline, increases the sympathomimetic effect of norepinephrine.
Phenelzine Increased arterial pressure
Rasagiline Increased arterial pressure
Reserpine Increased arterial pressure
Trimipramine Trimipramine may increase the vasopressor effect of the direct-acting alpha-/beta-agonist, Norepinephrine. Avoid combination if possible. Monitor sympathetic response to therapy if used concomitantly.
Venlafaxine Venlafaxine may increase the tachycardic and vasopressor effects of Norepinephrine. Consider alternate therapy or monitor for increased sympathomimetic effects, such as increased blood pressure, chest pain and headache.
Food Interactions Not Available

Targets


Alpha-1A adrenergic receptor
Name Alpha-1A adrenergic receptor
Gene Name ADRA1A
Pharmacological action yes
Actions agonist
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Lachnit WG, Tran AM, Clarke DE, Ford AP: Pharmacological characterization of an alpha 1A-adrenoceptor mediating contractile responses to noradrenaline in isolated caudal artery of rat. Br J Pharmacol. 1997 Mar;120(5):819-26. - Pubmed
  • Burt RP, Chapple CR, Marshall I: The role of diacylglycerol and activation of protein kinase C in alpha 1A-adrenoceptor-mediated contraction to noradrenaline of rat isolated epididymal vas deferens. Br J Pharmacol. 1996 Jan;117(1):224-30. - Pubmed
  • Bishop MJ: Recent advances in the discovery of alpha1-adrenoceptor agonists. Curr Top Med Chem. 2007;7(2):135-45. - Pubmed
DTHybrid score 0.8038
Alpha-1B adrenergic receptor
Name Alpha-1B adrenergic receptor
Gene Name ADRA1B
Pharmacological action yes
Actions agonist
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Izzo NJ Jr, Tulenko TN, Colucci WS: Phorbol esters and norepinephrine destabilize alpha 1B-adrenergic receptor mRNA in vascular smooth muscle cells. J Biol Chem. 1994 Jan 21;269(3):1705-10. - Pubmed
  • Testa R, Guarneri L, Poggesi E, Simonazzi I, Taddei C, Leonardi A: Mediation of noradrenaline-induced contractions of rat aorta by the alpha 1B-adrenoceptor subtype. Br J Pharmacol. 1995 Feb;114(4):745-50. - Pubmed
  • Izzo NJ Jr, Colucci WS: Regulation of alpha 1B-adrenergic receptor half-life: protein synthesis dependence and effect of norepinephrine. Am J Physiol. 1994 Mar;266(3 Pt 1):C771-5. - Pubmed
  • Bishop MJ: Recent advances in the discovery of alpha1-adrenoceptor agonists. Curr Top Med Chem. 2007;7(2):135-45. - Pubmed
  • Gilsbach R, Hein L: Presynaptic metabotropic receptors for acetylcholine and adrenaline/noradrenaline. Handb Exp Pharmacol. 2008;(184):261-88. - Pubmed
DTHybrid score 0.5656
Alpha-1D adrenergic receptor
Name Alpha-1D adrenergic receptor
Gene Name ADRA1D
Pharmacological action yes
Actions agonist
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Cleary L, Slattery J, Bexis S, Docherty JR: Sympathectomy reveals alpha 1A- and alpha 1D-adrenoceptor components to contractions to noradrenaline in rat vas deferens. Br J Pharmacol. 2004 Nov;143(6):745-52. Epub 2004 Sep 27. - Pubmed
  • Kenny BA, Chalmers DH, Philpott PC, Naylor AM: Characterization of an alpha 1D-adrenoceptor mediating the contractile response of rat aorta to noradrenaline. Br J Pharmacol. 1995 Jul;115(6):981-6. - Pubmed
  • Testa R, Destefani C, Guarneri L, Poggesi E, Simonazzi I, Taddei C, Leonardi A: The alpha 1d-adrenoceptor subtype is involved in the noradrenaline-induced contractions of rat aorta. Life Sci. 1995;57(13):PL159-63. - Pubmed
  • Bishop MJ: Recent advances in the discovery of alpha1-adrenoceptor agonists. Curr Top Med Chem. 2007;7(2):135-45. - Pubmed
  • Gilsbach R, Hein L: Presynaptic metabotropic receptors for acetylcholine and adrenaline/noradrenaline. Handb Exp Pharmacol. 2008;(184):261-88. - Pubmed
DTHybrid score 0.4254
Alpha-2A adrenergic receptor
Name Alpha-2A adrenergic receptor
Gene Name ADRA2A
Pharmacological action yes
Actions agonist
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Nyronen T, Pihlavisto M, Peltonen JM, Hoffren AM, Varis M, Salminen T, Wurster S, Marjamaki A, Kanerva L, Katainen E, Laaksonen L, Savola JM, Scheinin M, Johnson MS: Molecular mechanism for agonist-promoted alpha(2A)-adrenoceptor activation by norepinephrine and epinephrine. Mol Pharmacol. 2001 May;59(5):1343-54. - Pubmed
  • MacLennan SJ, Reynen PH, Martin RS, Eglen RM, Martin GR: Characterization of human recombinant alpha(2A)-adrenoceptors expressed in Chinese hamster lung cells using extracellular acidification rate changes. Br J Pharmacol. 2000 Apr;129(7):1333-8. - Pubmed
  • Hieble JP, Hehr A, Li YO, Ruffolo RR Jr: Molecular basis for the stereoselective interactions of catecholamines with alpha-adrenoceptors. Proc West Pharmacol Soc. 1998;41:225-8. - Pubmed
  • Nash DT: Alpha-adrenergic blockers: mechanism of action, blood pressure control, and effects of lipoprotein metabolism. Clin Cardiol. 1990 Nov;13(11):764-72. - Pubmed
  • Giovannoni MP, Ghelardini C, Vergelli C, Dal Piaz V: Alpha2-agonists as analgesic agents. Med Res Rev. 2009 Mar;29(2):339-68. - Pubmed
  • Gilsbach R, Hein L: Presynaptic metabotropic receptors for acetylcholine and adrenaline/noradrenaline. Handb Exp Pharmacol. 2008;(184):261-88. - Pubmed
DTHybrid score 0.6926
Alpha-2B adrenergic receptor
Name Alpha-2B adrenergic receptor
Gene Name ADRA2B
Pharmacological action yes
Actions agonist
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Gobbi M, Frittoli E, Mennini T: The modulation of [3H]noradrenaline and [3H]serotonin release from rat brain synaptosomes is not mediated by the alpha 2B-adrenoceptor subtype. Naunyn Schmiedebergs Arch Pharmacol. 1990 Oct;342(4):382-6. - Pubmed
  • Vizi ES, Katona I, Freund TF: Evidence for presynaptic cannabinoid CB(1) receptor-mediated inhibition of noradrenaline release in the guinea pig lung. Eur J Pharmacol. 2001 Nov 16;431(2):237-44. - Pubmed
  • Rudling JE, Richardson J, Evans PD: A comparison of agonist-specific coupling of cloned human alpha(2)-adrenoceptor subtypes. Br J Pharmacol. 2000 Nov;131(5):933-41. - Pubmed
  • Nash DT: Alpha-adrenergic blockers: mechanism of action, blood pressure control, and effects of lipoprotein metabolism. Clin Cardiol. 1990 Nov;13(11):764-72. - Pubmed
  • Gilsbach R, Hein L: Presynaptic metabotropic receptors for acetylcholine and adrenaline/noradrenaline. Handb Exp Pharmacol. 2008;(184):261-88. - Pubmed
DTHybrid score 0.4834
Alpha-2C adrenergic receptor
Name Alpha-2C adrenergic receptor
Gene Name ADRA2C
Pharmacological action yes
Actions agonist
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Shreve PE, Toews ML, Bylund DB: Alpha 2A- and alpha 2C-adrenoceptor subtypes are differentially down-regulated by norepinephrine. Eur J Pharmacol. 1991 Jul 12;207(3):275-6. - Pubmed
  • Rump LC, Bohmann C, Schaible U, Schollhorn J, Limberger N: Alpha 2C-adrenoceptor-modulated release of noradrenaline in human right atrium. Br J Pharmacol. 1995 Nov;116(6):2617-24. - Pubmed
  • Bruck H, Schwerdtfeger T, Toliat M, Leineweber K, Heusch G, Philipp T, Nurnberg P, Brodde OE: Presynaptic alpha-2C Adrenoceptor-mediated Control of Noradrenaline Release in Humans: Genotype- or Age-Dependent? Clin Pharmacol Ther. 2007 Apr 4;. - Pubmed
  • Nash DT: Alpha-adrenergic blockers: mechanism of action, blood pressure control, and effects of lipoprotein metabolism. Clin Cardiol. 1990 Nov;13(11):764-72. - Pubmed
  • Gilsbach R, Hein L: Presynaptic metabotropic receptors for acetylcholine and adrenaline/noradrenaline. Handb Exp Pharmacol. 2008;(184):261-88. - Pubmed
DTHybrid score 0.4605
Beta-1 adrenergic receptor
Name Beta-1 adrenergic receptor
Gene Name ADRB1
Pharmacological action yes
Actions agonist
References
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
  • Mersmann HJ: Overview of the effects of beta-adrenergic receptor agonists on animal growth including mechanisms of action. J Anim Sci. 1998 Jan;76(1):160-72. - Pubmed
  • El-Armouche A, Eschenhagen T: Beta-adrenergic stimulation and myocardial function in the failing heart. Heart Fail Rev. 2009 Dec;14(4):225-41. - Pubmed
  • Gilsbach R, Hein L: Presynaptic metabotropic receptors for acetylcholine and adrenaline/noradrenaline. Handb Exp Pharmacol. 2008;(184):261-88. - Pubmed
DTHybrid score 1.0058
Beta-2 adrenergic receptor
Name Beta-2 adrenergic receptor
Gene Name ADRB2
Pharmacological action yes
Actions agonist
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Sanders VM: The role of norepinephrine and beta-2-adrenergic receptor stimulation in the modulation of Th1, Th2, and B lymphocyte function. Adv Exp Med Biol. 1998;437:269-78. - Pubmed
  • Tarizzo VI, Coppes RP, Dahlof C, Zaagsma J: Pre- and postganglionic stimulation-induced noradrenaline overflow is markedly facilitated by a prejunctional beta 2-adrenoceptor-mediated control mechanism in the pithed rat. Naunyn Schmiedebergs Arch Pharmacol. 1994 Jun;349(6):570-7. - Pubmed
  • Weinshenker D, Szot P, Miller NS, Palmiter RD: Alpha(1) and beta(2) adrenoreceptor agonists inhibit pentylenetetrazole-induced seizures in mice lacking norepinephrine. J Pharmacol Exp Ther. 2001 Sep;298(3):1042-8. - Pubmed
  • Mersmann HJ: Overview of the effects of beta-adrenergic receptor agonists on animal growth including mechanisms of action. J Anim Sci. 1998 Jan;76(1):160-72. - Pubmed
  • El-Armouche A, Eschenhagen T: Beta-adrenergic stimulation and myocardial function in the failing heart. Heart Fail Rev. 2009 Dec;14(4):225-41. - Pubmed
  • Gilsbach R, Hein L: Presynaptic metabotropic receptors for acetylcholine and adrenaline/noradrenaline. Handb Exp Pharmacol. 2008;(184):261-88. - Pubmed
DTHybrid score 1.0162
Beta-3 adrenergic receptor
Name Beta-3 adrenergic receptor
Gene Name ADRB3
Pharmacological action yes
Actions agonist
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Carpene C, Galitzky J, Collon P, Esclapez F, Dauzats M, Lafontan M: Desensitization of beta-1 and beta-2, but not beta-3, adrenoceptor-mediated lipolytic responses of adipocytes after long-term norepinephrine infusion. J Pharmacol Exp Ther. 1993 Apr;265(1):237-47. - Pubmed
  • Galitzky J, Carpene C, Lafontan M, Berlan M: [Specific stimulation of adipose tissue adrenergic beta 3 receptors by octopamine] C R Acad Sci III. 1993;316(5):519-23. - Pubmed
  • Tamaoki J, Chiyotani A, Sakai N, Konno K: Stimulation of ciliary motility mediated by atypical beta-adrenoceptor in canine bronchial epithelium. Life Sci. 1993;53(20):1509-15. - Pubmed
  • Mersmann HJ: Overview of the effects of beta-adrenergic receptor agonists on animal growth including mechanisms of action. J Anim Sci. 1998 Jan;76(1):160-72. - Pubmed
DTHybrid score 0.5358
Phenylalanine-4-hydroxylase
Name Phenylalanine-4-hydroxylase
Gene Name PAH
Pharmacological action no
Actions inhibitor
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Martinez A, Andersson KK, Haavik J, Flatmark T: EPR and 1H-NMR spectroscopic studies on the paramagnetic iron at the active site of phenylalanine hydroxylase and its interaction with substrates and inhibitors. Eur J Biochem. 1991 Jun 15;198(3):675-82. - Pubmed
  • Martinez A, Haavik J, Flatmark T: Cooperative homotropic interaction of L-noradrenaline with the catalytic site of phenylalanine 4-monooxygenase. Eur J Biochem. 1990 Oct 5;193(1):211-9. - Pubmed
  • Molinoff PB: The regulation of the noradrenergic neuron. J Psychiatr Res. 1974;11:339-45. - Pubmed
DTHybrid score 0.7116

Enzymes


Cytochrome P450 1A2
Name Cytochrome P450 1A2
Gene Name CYP1A2
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.4837

Transporters


Sodium-dependent noradrenaline transporter
Name Sodium-dependent noradrenaline transporter
Gene Name SLC6A2
Actions substrate
References
  • Habecker BA, Willison BD, Shi X, Woodward WR: Chronic depolarization stimulates norepinephrine transporter expression via catecholamines. J Neurochem. 2006 May;97(4):1044-51. Epub 2006 Mar 29. - Pubmed
  • Bonisch H, Bruss M: The norepinephrine transporter in physiology and disease. Handb Exp Pharmacol. 2006;(175):485-524. - Pubmed
  • Mandela P, Ordway GA: KCl stimulation increases norepinephrine transporter function in PC12 cells. J Neurochem. 2006 Sep;98(5):1521-30. Epub 2006 Jul 31. - Pubmed
  • Gutman DA, Owens MJ: Serotonin and norepinephrine transporter binding profile of SSRIs. Essent Psychopharmacol. 2006;7(1):35-41. - Pubmed
  • Ksiazek P, Buraczynska K, Buraczynska M: Norepinephrine transporter gene (NET) polymorphism in patients with type 2 diabetes. Kidney Blood Press Res. 2006;29(6):338-43. Epub 2006 Nov 23. - Pubmed
DTHybrid score 0.5254
Solute carrier family 22 member 2
Name Solute carrier family 22 member 2
Gene Name SLC22A2
Actions substrate,inhibitor
References
  • Urakami Y, Akazawa M, Saito H, Okuda M, Inui K: cDNA cloning, functional characterization, and tissue distribution of an alternatively spliced variant of organic cation transporter hOCT2 predominantly expressed in the human kidney. J Am Soc Nephrol. 2002 Jul;13(7):1703-10. - Pubmed
  • Wu X, Kekuda R, Huang W, Fei YJ, Leibach FH, Chen J, Conway SJ, Ganapathy V: Identity of the organic cation transporter OCT3 as the extraneuronal monoamine transporter (uptake2) and evidence for the expression of the transporter in the brain. J Biol Chem. 1998 Dec 4;273(49):32776-86. - Pubmed
  • Busch AE, Karbach U, Miska D, Gorboulev V, Akhoundova A, Volk C, Arndt P, Ulzheimer JC, Sonders MS, Baumann C, Waldegger S, Lang F, Koepsell H: Human neurons express the polyspecific cation transporter hOCT2, which translocates monoamine neurotransmitters, amantadine, and memantine. Mol Pharmacol. 1998 Aug;54(2):342-52. - Pubmed
  • Grundemann D, Koster S, Kiefer N, Breidert T, Engelhardt M, Spitzenberger F, Obermuller N, Schomig E: Transport of monoamine transmitters by the organic cation transporter type 2, OCT2. J Biol Chem. 1998 Nov 20;273(47):30915-20. - Pubmed
DTHybrid score 0.4151
Solute carrier family 22 member 3
Name Solute carrier family 22 member 3
Gene Name SLC22A3
Actions substrate,inhibitor
References
  • Wu X, Kekuda R, Huang W, Fei YJ, Leibach FH, Chen J, Conway SJ, Ganapathy V: Identity of the organic cation transporter OCT3 as the extraneuronal monoamine transporter (uptake2) and evidence for the expression of the transporter in the brain. J Biol Chem. 1998 Dec 4;273(49):32776-86. - Pubmed
  • Grundemann D, Schechinger B, Rappold GA, Schomig E: Molecular identification of the corticosterone-sensitive extraneuronal catecholamine transporter. Nat Neurosci. 1998 Sep;1(5):349-51. - Pubmed
DTHybrid score 0.3238
Organic cation/carnitine transporter 2
Name Organic cation/carnitine transporter 2
Gene Name SLC22A5
Actions inhibitor
References
  • Ohashi R, Tamai I, Nezu Ji J, Nikaido H, Hashimoto N, Oku A, Sai Y, Shimane M, Tsuji A: Molecular and physiological evidence for multifunctionality of carnitine/organic cation transporter OCTN2. Mol Pharmacol. 2001 Feb;59(2):358-66. - Pubmed
  • Wu X, Huang W, Prasad PD, Seth P, Rajan DP, Leibach FH, Chen J, Conway SJ, Ganapathy V: Functional characteristics and tissue distribution pattern of organic cation transporter 2 (OCTN2), an organic cation/carnitine transporter. J Pharmacol Exp Ther. 1999 Sep;290(3):1482-92. - Pubmed
DTHybrid score 0.3628
Solute carrier family 22 member 1
Name Solute carrier family 22 member 1
Gene Name SLC22A1
Actions substrate
References
  • Busch AE, Quester S, Ulzheimer JC, Gorboulev V, Akhoundova A, Waldegger S, Lang F, Koepsell H: Monoamine neurotransmitter transport mediated by the polyspecific cation transporter rOCT1. FEBS Lett. 1996 Oct 21;395(2-3):153-6. - Pubmed
  • Breidert T, Spitzenberger F, Grundemann D, Schomig E: Catecholamine transport by the organic cation transporter type 1 (OCT1). Br J Pharmacol. 1998 Sep;125(1):218-24. - Pubmed
DTHybrid score 0.4671
POU domain, class 5, transcription factor 1
Name POU domain, class 5, transcription factor 1
Gene Name POU5F1
Actions substrate
References
  • Zhu HJ, Appel DI, Grundemann D, Markowitz JS: Interaction of organic cation transporter 3 (SLC22A3) and amphetamine. J Neurochem. 2010 Jul;114(1):142-9. Epub 2010 Apr 6. - Pubmed
DTHybrid score 0.1801

Predictions


Id Partner name Gene Name Score
3109 Phenylalanine-4-hydroxylase phhA 0.7116
4119 Cytochrome P450 2D6 CYP2D6 0.4852
4512 Cytochrome P450 3A4 CYP3A4 0.3873
1588 Multidrug resistance protein 1 ABCB1 0.2899
320 5-hydroxytryptamine 1A receptor HTR1A 0.2416
713 Sodium-dependent dopamine transporter SLC6A3 0.2361
502 5-hydroxytryptamine 2A receptor HTR2A 0.2361
23 D(1A) dopamine receptor DRD1 0.2337
831 D(2) dopamine receptor DRD2 0.2263
824 Sodium-dependent serotonin transporter SLC6A4 0.2185
6016 Cytochrome P450 2C19 CYP2C19 0.1884
4757 Cytochrome P450 2C9 CYP2C9 0.1693
885 5-hydroxytryptamine 1B receptor HTR1B 0.1661
590 5-hydroxytryptamine 2C receptor HTR2C 0.1642
432 D(4) dopamine receptor DRD4 0.1552
492 Histamine H1 receptor HRH1 0.1543
638 D(3) dopamine receptor DRD3 0.1479
163 D(1B) dopamine receptor DRD5 0.1448
6024 Cytochrome P450 1A1 CYP1A1 0.1345
3941 Amine oxidase [flavin-containing] A MAOA 0.1322
1181 Alpha-1-acid glycoprotein 1 ORM1 0.1311
833 Organic cation/carnitine transporter 1 SLC22A4 0.1275
4118 Cytochrome P450 3A5 CYP3A5 0.1258
725 5-hydroxytryptamine 1D receptor HTR1D 0.1236
131 Synaptic vesicular amine transporter SLC18A2 0.118
5666 Parathyroid hormone PTH 0.1158
6107 Cytochrome P450 3A7 CYP3A7 0.0955
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0949
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.094
6013 Cytochrome P450 2E1 CYP2E1 0.0937
617 Muscarinic acetylcholine receptor M2 CHRM2 0.093
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0908
3939 Amine oxidase [flavin-containing] B MAOB 0.089
6030 Cytochrome P450 2B6 CYP2B6 0.088
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0843
3923 Cholinesterase BCHE 0.0836
436 5-hydroxytryptamine 2B receptor HTR2B 0.0829
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0821
676 Tyrosine 3-monooxygenase TH 0.0797
587 Serum albumin ALB 0.0743
4924 Cytochrome P450 2C8 CYP2C8 0.0729
716 5-hydroxytryptamine 7 receptor HTR7 0.0716
6142 Solute carrier family 22 member 8 SLC22A8 0.0702
7 Nitric oxide synthase, inducible NOS2 0.0618
1729 Solute carrier family 22 member 6 SLC22A6 0.0605
6070 Nischarin NISCH 0.0593
3810 Catechol O-methyltransferase COMT 0.0575
5718 Cytochrome P450 2A6 CYP2A6 0.0566
1256 5-hydroxytryptamine 6 receptor HTR6 0.0555
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0552
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0543
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0527
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0518
341 5-hydroxytryptamine 3 receptor HTR3A 0.0508
291 Nitric-oxide synthase, endothelial NOS3 0.0503
1636 Trace amine-associated receptor 1 TAAR1 0.0495
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.049
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.049
124 Histamine H2 receptor HRH2 0.048
6151 Monocarboxylate transporter 10 SLC16A10 0.0469
1820 Beta-nerve growth factor NGF 0.0469
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0465
862 Multidrug resistance-associated protein 1 ABCC1 0.0431
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0415
4146 Phosphatidylinositol 3-kinase regulatory subunit gamma PIK3R3 0.0408
4145 Phosphatidylinositol 3-kinase regulatory subunit beta PIK3R2 0.0408
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0376
477 DNA topoisomerase 4 subunit A parC 0.0361
886 DNA topoisomerase 4 subunit A parC 0.0361
6226 DNA topoisomerase 4 subunit A parC 0.0361
153 Dopamine beta-hydroxylase DBH 0.036
404 DNA gyrase subunit A gyrA 0.0356
6224 DNA gyrase subunit A gyrA 0.0356
2675 Pteridine reductase 1 PTR1 0.035
1281 Phosphatidylinositol 3-kinase regulatory subunit alpha PIK3R1 0.0345
465 Calmodulin CALM1 0.0344
777 Tumor necrosis factor TNF 0.0336
134 Tryptophan 5-hydroxylase 1 TPH1 0.0336
2300 Lysozyme E 0.0334
3633 Lysozyme R 0.0334
5597 Lysozyme 17 0.0334
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0332
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.033
220 Sodium channel protein type 5 subunit alpha SCN5A 0.032
528 5-hydroxytryptamine 1E receptor HTR1E 0.0317
474 Acetylcholinesterase ACHE 0.0307
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0306
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0304
6106 Cytochrome P450 2C18 CYP2C18 0.03
76 Nitric-oxide synthase, brain NOS1 0.0299
776 Bile salt export pump ABCB11 0.0294
2360 Dihydroneopterin aldolase folB 0.0293
1024 Solute carrier family 22 member 11 SLC22A11 0.0288
6138 Multidrug resistance protein 3 ABCB4 0.0281
6020 Aldehyde oxidase AOX1 0.0278
6143 Solute carrier family 22 member 7 SLC22A7 0.0268
817 DNA topoisomerase 2-alpha TOP2A 0.0267
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0264
281 5'-AMP-activated protein kinase subunit beta-1 PRKAB1 0.0264
1898 Cytochrome P450 1B1 CYP1B1 0.0261
20 Prostaglandin G/H synthase 1 PTGS1 0.026
36 Insulin receptor INSR 0.0258
290 Prostaglandin G/H synthase 2 PTGS2 0.0258
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0254
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0253
31 Phenylalanyl-tRNA synthetase, mitochondrial FARS2 0.0251
42 Phenylalanyl-tRNA synthetase alpha chain FARSA 0.0251
6602 Phenylalanyl-tRNA synthetase alpha chain pheS 0.0251
618 Phenylalanyl-tRNA synthetase beta chain FARSB 0.0251
6603 Phenylalanyl-tRNA synthetase beta chain pheT 0.0251
6010 Thiamine transporter 1 SLC19A2 0.0248
1176 Mitogen-activated protein kinase 1 MAPK1 0.023
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0226
6432 Transporter snf 0.0226
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0223
175 Thiamin pyrophosphokinase 1 TPK1 0.0222
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0216
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0208
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0208
164 Histamine H4 receptor HRH4 0.0206
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0205
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0204
2472 Voltage-gated potassium channel kcsA 0.0203
6366 Voltage-gated potassium channel kcsA 0.0203
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0199
1757 Myeloperoxidase MPO 0.0198
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0194
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0192
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0192
2164 Multidrug resistance-associated protein 4 ABCC4 0.0189
866 Large neutral amino acids transporter small subunit 2 SLC7A8 0.018
763 Tyrosine aminotransferase TAT 0.0178
5493 Tyrosine aminotransferase Not Available 0.0178
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0178
3811 Cytochrome P450 19A1 CYP19A1 0.0175
624 Guanidinoacetate N-methyltransferase GAMT 0.0175
6148 Multidrug resistance-associated protein 7 ABCC10 0.0172
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0172
1064 DNA (cytosine-5)-methyltransferase 1 DNMT1 0.0167
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0167
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0167
159 Penicillin-binding protein 2B penA 0.0165
6121 Penicillin-binding protein 2B penA 0.0165
233 Potassium channel subfamily K member 2 KCNK2 0.0165
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0163
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0163
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0162
982 Cocaine- and amphetamine-regulated transcript protein CARTPT 0.0161
5126 Arginase rocF 0.0161
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0161
3947 Xanthine dehydrogenase/oxidase XDH 0.016
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.016
5626 Nucleoside diphosphate kinase B NME2 0.0156
4773 Deoxycytidine kinase DCK 0.0153
4203 Histamine N-methyltransferase HNMT 0.0152
1341 Histamine H3 receptor HRH3 0.0151
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0149
738 Monocarboxylate transporter 1 SLC16A1 0.0148
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0148
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0142
1360 Sphingomyelin phosphodiesterase SMPD1 0.0141
6137 Multidrug resistance-associated protein 6 ABCC6 0.0141
198 Sodium channel protein type 10 subunit alpha SCN10A 0.014
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0138
6136 Multidrug resistance-associated protein 5 ABCC5 0.0134
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.013
136 Estrogen receptor ESR1 0.0126
672 Prostaglandin F2-alpha receptor PTGFR 0.0125
696 Kappa-type opioid receptor OPRK1 0.0125
5294 Nucleoside diphosphate kinase A NME1 0.0125
4292 Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase lpxA 0.0124
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0122
3076 Antigen 85-C fbpC 0.0122
6014 Cytochrome P450 2A13 CYP2A13 0.0121
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0121
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0116
6141 Sodium/bile acid cotransporter SLC10A1 0.0107
161 Tubulin beta chain TUBB 0.0106
312 Tubulin beta chain TUB2 0.0106
1656 CYP2B protein CYP2B 0.0105
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0105
467 Delta-type opioid receptor OPRD1 0.0104
633 Penicillin-binding proteins 1A/1B pbpA 0.0104
380 Cytochrome P450 17A1 CYP17A1 0.0102
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.01
115 Penicillin-binding protein 2 mrdA 0.0099
6069 Penicillin-binding protein 2 mrdA 0.0099
6118 Penicillin-binding protein 2 penA 0.0099
6187 Penicillin-binding protein 2 pbpA 0.0099
6686 Penicillin-binding protein 2 pbp2 0.0099
6939 Penicillin-binding protein 2 mrdA 0.0099
7163 Penicillin-binding protein 2 pbpA 0.0099
756 Sex hormone-binding globulin SHBG 0.0098
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0098
509 Thymidine kinase TK 0.0097
570 Thymidine kinase TK 0.0097
2559 Thymidine kinase TK 0.0097
3430 Thymidine kinase tdk 0.0097
3518 Thymidine kinase TK 0.0097
5301 Thymidine kinase tdk 0.0097
5771 Thymidine kinase ORF36 0.0097
7009 Thymidine kinase ORF36 0.0097
958 Insulin-like growth factor 1 receptor IGF1R 0.0097
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0096
1830 5'-nucleotidase NT5E 0.0094
6847 Lactase-phlorizin hydrolase LCT 0.0093
904 Glutathione S-transferase P GSTP1 0.0092
342 P protein [Includes: DNA-directed DNA polymerase P 0.0091
612 P protein [Includes: DNA-directed DNA polymerase P 0.0091
3929 Phosphoethanolamine/phosphocholine phosphatase PHOSPHO1 0.009
549 Choline-phosphate cytidylyltransferase B PCYT1B 0.009
3927 Choline transporter-like protein 3 SLC44A3 0.009
3933 Choline/ethanolaminephosphotransferase CEPT1 0.009
769 High-affinity choline transporter 1 SLC5A7 0.009
3926 Choline transporter-like protein 2 SLC44A2 0.009
861 Choline kinase alpha CHKA 0.009
1686 Choline transporter-like protein 1 SLC44A1 0.009
264 Choline/ethanolamine kinase [Includes: Choline kinase beta CHKB 0.009
700 Choline dehydrogenase, mitochondrial CHDH 0.009
3925 Choline transporter-like protein 4 SLC44A4 0.009
576 Choline O-acetyltransferase CHAT 0.009
3922 Phospholipase D2 PLD2 0.009
3924 Phospholipase D1 PLD1 0.009
6146 High affinity copper uptake protein 1 SLC31A1 0.0089
5682 Ribonuclease pancreatic RNASE1 0.0089
1680 Solute carrier family 2, facilitated glucose transporter member 1 SLC2A1 0.0089
1374 Natriuretic peptides B NPPB 0.0088
4120 NADPH--cytochrome P450 reductase POR 0.0088
1827 Gap junction alpha-1 protein GJA1 0.0088
1908 Vascular cell adhesion protein 1 VCAM1 0.0088
1618 High affinity nerve growth factor receptor NTRK1 0.0087
6165 Copper-transporting ATPase 1 ATP7A 0.0086
6163 Copper-transporting ATPase 2 ATP7B 0.0086
694 Matrix protein 2 M 0.0086
737 Mineralocorticoid receptor NR3C2 0.0086
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0085
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0084
3426 Glutamine synthetase glnA 0.0084
3987 Glutamine synthetase GLUL 0.0084
908 Glutathione S-transferase theta-1 GSTT1 0.0083
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0083
1 Peptidoglycan synthetase ftsI ftsI 0.0083
4155 Peptidoglycan synthetase ftsI ftsI 0.0083
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0081
213 Amiloride-sensitive sodium channel subunit alpha SCNN1A 0.0081
550 Amiloride-sensitive sodium channel subunit delta SCNN1D 0.0081
27 Amiloride-sensitive sodium channel subunit beta SCNN1B 0.0081
552 Amiloride-sensitive sodium channel subunit gamma SCNN1G 0.0081
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0081
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0079
976 Platelet glycoprotein IX GP9 0.0079
867 Penicillin-binding protein 3 pbpC 0.0077
6119 Penicillin-binding protein 3 pbp3 0.0077
7154 Penicillin-binding protein 3 pbp3 0.0077
7157 Penicillin-binding protein 3 LMHCC_2184 0.0077
7162 Penicillin-binding protein 3 pbpB 0.0077
7172 Penicillin-binding protein 3 pbp3 0.0077
3704 Spermidine/putrescine-binding periplasmic protein precursor potD 0.0077
125 DNA polymerase beta POLB 0.0074
338 DNA polymerase UL30 0.0073
379 DNA polymerase UL54 0.0073
697 DNA polymerase ORF28 0.0073
2482 DNA polymerase 43 0.0073
4104 DNA polymerase BALF5 0.0073
869 Estrogen receptor beta ESR2 0.0073
645 Penicillin-binding protein 1A mrcA 0.0073
5805 Penicillin-binding protein 1A ponA 0.0073
6185 Penicillin-binding protein 1A mrcA 0.0073
6799 Penicillin-binding protein 1A pbpA 0.0073
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0072
702 UMP-CMP kinase CMPK1 0.0072
847 Mu-type opioid receptor OPRM1 0.0072
6171 Solute carrier family 28 member 3 SLC28A3 0.007
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0069
896 Glutathione S-transferase Mu 1 GSTM1 0.0069
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0069
731 HIV-1 protease HIV-1 protease 0.0068
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0067
3560 Gentamicin 3'-acetyltransferase aacC1 0.0067
749 Amiloride-sensitive cation channel 1, neuronal ACCN1 0.0066
16 Adenosine A1 receptor ADORA1 0.0066
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0066
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0066
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0066
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0066
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0065
183 Vascular endothelial growth factor A VEGFA 0.0065
3611 Cytidine deaminase cdd 0.0065
3707 Cytidine deaminase cdd 0.0065
4211 Cytidine deaminase CDA 0.0065
192 Creatine kinase, ubiquitous mitochondrial CKMT1A 0.0063
456 Creatine kinase, sarcomeric mitochondrial CKMT2 0.0063
92 Creatine kinase B-type CKB 0.0063
414 Sodium- and chloride-dependent creatine transporter 1 SLC6A8 0.0063
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0062
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0062
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.006
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.006
332 Beta-lactamase blaZ 0.0059
2478 Beta-lactamase ampC 0.0059
2613 Beta-lactamase ampC 0.0059
2635 Beta-lactamase ampC 0.0059
2700 Beta-lactamase penP 0.0059
5445 Beta-lactamase blaB 0.0059
6019 Beta-lactamase SHV-7 0.0059
6701 Beta-lactamase cphA 0.0059
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0059
387 Amiloride-sensitive amine oxidase [copper-containing] ABP1 0.0059
7187 Amiloride-sensitive amine oxidase [copper-containing] ABP1 0.0059
6067 Penicillin binding protein 2a mecA 0.0058
6111 DNA polymerase epsilon subunit 4 POLE4 0.0058
827 Sodium/hydrogen exchanger 1 SLC9A1 0.0058
6112 DNA polymerase epsilon subunit 3 POLE3 0.0058
6108 Ribonucleoside-diphosphate reductase subunit M2 B RRM2B 0.0058
6110 DNA polymerase epsilon subunit 2 POLE2 0.0058
6109 DNA polymerase epsilon catalytic subunit A POLE 0.0058
788 Creatine kinase M-type CKM 0.0057
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0056
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0056
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0056
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0056
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0056
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0056
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0055
1770 Phospholipase C PLCL1 0.0055
2841 Phospholipase C plc 0.0055
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0054
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0054
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0054
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0053
1178 Adenosine A2a receptor ADORA2A 0.0053
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0053
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0052
571 Melatonin receptor type 1A MTNR1A 0.0052
482 Glycine receptor subunit alpha-1 GLRA1 0.0052
362 Melatonin receptor type 1B MTNR1B 0.0052
4604 Liver carboxylesterase 1 CES1 0.0052
860 Nicotinamide N-methyltransferase NNMT 0.0051
583 Nicotinate-nucleotide pyrophosphorylase [carboxylating] QPRT 0.0051
2442 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0051
2459 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0051
699 Nicotinic acid receptor 1 GPR109A 0.0051
928 Nicotinic acid receptor 2 GPR109B 0.0051
751 Potassium channel subfamily K member 6 KCNK6 0.0051
6182 Cytochrome P450 2J2 CYP2J2 0.0051
4218 Ribonucleoside-diphosphate reductase M2 subunit RRM2 0.005
6859 Protein S100-A4 S100A4 0.0048
6218 Pannexin-1 PANX1 0.0047
172 Potassium channel subfamily K member 1 KCNK1 0.0047
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0047
2981 Phospholipase A2, membrane associated PLA2G2A 0.0047
29 Tubulin beta-1 chain TUBB1 0.0046
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0045
6220 Aryl hydrocarbon receptor AHR 0.0045
303 Diamine acetyltransferase 2 SAT2 0.0045
623 Spermine oxidase SMOX 0.0045
1317 Spermine synthase SMS 0.0045
468 Cytochrome P450 4A11 CYP4A11 0.0044
6167 Organic solute transporter subunit beta OSTB 0.0044
6166 Organic solute transporter subunit alpha OSTA 0.0044
228 Beta platelet-derived growth factor receptor PDGFRB 0.0044
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0044
603 DNA polymerase alpha catalytic subunit POLA1 0.0043
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0043
3755 Nucleoside-specific channel-forming protein tsx precursor tsx 0.0043
6149 Solute carrier family 22 member 10 SLC22A10 0.0042
614 Progesterone receptor PGR 0.0042
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0042
714 Glutathione reductase, mitochondrial GSR 0.0042
2539 Tubulin alpha-1 chain TUBA4A 0.0042
6031 Cytochrome P450 3A43 CYP3A43 0.0042
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.0041
504 Mast/stem cell growth factor receptor KIT 0.0041
123 Diamine acetyltransferase 1 SAT1 0.004
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.004
6085 Fatty acid-binding protein, intestinal FABP2 0.004
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0039
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0039
1864 RET proto-oncogene RET 0.0039
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0039
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0039
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0039
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0038
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0038
605 Fumarate reductase flavoprotein subunit frdA 0.0038
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0038
3673 Fumarate reductase flavoprotein subunit fccA 0.0038
4912 Fumarate reductase flavoprotein subunit ifcA 0.0038
6549 Fumarate reductase flavoprotein subunit frdA 0.0038
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0038
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0038
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0037
511 5-hydroxytryptamine 1F receptor HTR1F 0.0037
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0037
527 Prostacyclin receptor PTGIR 0.0036
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0036
723 Cytosolic phospholipase A2 PLA2G4A 0.0036
1629 Transcription factor AP-1 JUN 0.0036
2449 Tubulin alpha-3 chain TUBA1A 0.0036
1074 Urokinase-type plasminogen activator PLAU 0.0036
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0035
5998 Toll-like receptor 8 TLR8 0.0035
273 Apoptosis regulator Bcl-2 BCL2 0.0034
565 Extracellular calcium-sensing receptor CASR 0.0034
712 Tubulin alpha chain TUB1 0.0034
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0033
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0033
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0033
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0033
4122 Histone deacetylase 2 HDAC2 0.0033
277 Purine nucleoside phosphorylase PNP 0.0033
2870 Purine nucleoside phosphorylase punA 0.0033
2945 Purine nucleoside phosphorylase punA 0.0033
4659 Purine nucleoside phosphorylase TM_1596 0.0033
4825 Purine nucleoside phosphorylase TTHA1435 0.0033
844 Epidermal growth factor receptor EGFR 0.0033
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0033
499 Arginine decarboxylase ADC 0.0033
613 Atrial natriuretic peptide receptor A NPR1 0.0033
2251 Thymidylate kinase tmk 0.0033
2254 Thymidylate kinase DTYMK 0.0033
3522 Thymidylate kinase tmk 0.0033
3478 Glucose-1-phosphate thymidylyltransferase rmlA 0.0032
4277 Glucose-1-phosphate thymidylyltransferase rmlA 0.0032
109 Mitochondrial carnitine/acylcarnitine carrier protein CACL SLC25A29 0.0032
636 Mitochondrial carnitine/acylcarnitine carrier protein SLC25A20 0.0032
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0032
500 Monocarboxylate transporter 4 SLC16A3 0.0032
2257 Uridine phosphorylase udp 0.0031
5132 Uridine phosphorylase udp 0.0031
449 Ornithine decarboxylase ODC1 0.0031
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0031
6212 Tubulin gamma-1 chain TUBG1 0.0031
6210 Tubulin delta chain TUBD1 0.0031
6211 Tubulin epsilon chain TUBE1 0.0031
577 Argininosuccinate lyase ASL 0.0031
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0031
834 Arginase-2, mitochondrial ARG2 0.0031
1353 DNA topoisomerase 1 TOP1 0.003
3552 DNA topoisomerase 1 topA 0.003
818 50S ribosomal protein L10 rplJ 0.003
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.003
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.003
259 Microsomal triglyceride transfer protein large subunit MTTP 0.003
173 Toll-like receptor 7 TLR7 0.003
150 Cationic amino acid transporter 3 SLC7A3 0.003
235 High-affinity cationic amino acid transporter 1 SLC7A1 0.003
58 Cationic amino acid transporter 4 SLC7A4 0.003
117 Sterol O-acyltransferase 1 SOAT1 0.003
489 Monocarboxylate transporter 2 SLC16A7 0.003
4192 DNA topoisomerase 2-beta TOP2B 0.0029
146 Androgen receptor AR 0.0029
992 Protein tyrosine kinase 2 beta PTK2B 0.0028
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0028
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0028
740 Argininosuccinate synthase ASS1 0.0028
865 Argininosuccinate synthase ASS1 0.0028
2680 Argininosuccinate synthase argG 0.0028
3194 Argininosuccinate synthase argG 0.0028
6044 Serum paraoxonase/lactonase 3 PON3 0.0028
6168 Solute carrier family 22 member 16 SLC22A16 0.0028
33 Cystine/glutamate transporter SLC7A11 0.0028
543 Penicillin-binding protein 1B mrcB 0.0028
6186 Penicillin-binding protein 1B ponB 0.0028
6822 Penicillin-binding protein 1b pbp1b 0.0028
6844 Penicillin-binding protein 1b pbp1b 0.0028
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0028
558 Solute carrier family 12 member 1 SLC12A1 0.0027
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0027
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0027
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0027
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0027
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0027
3849 Insulin-like growth factor-binding protein 7 IGFBP7 0.0027
2009 Protein NOV homolog NOV 0.0027
3847 Neuroendocrine convertase 2 PCSK2 0.0027
1949 Carboxypeptidase E CPE 0.0027
3850 Synaptotagmin-like protein 4 SYTL4 0.0027
3848 Neuroendocrine convertase 1 PCSK1 0.0027
3846 Retinoblastoma-associated protein RB1 0.0027
412 Peroxisomal carnitine O-octanoyltransferase CROT 0.0027
551 Carnitine O-acetyltransferase CRAT 0.0027
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.0026
790 DNA polymerase subunit alpha B POLA2 0.0026
94 5-hydroxytryptamine 4 receptor HTR4 0.0025
5880 Thrombopoietin receptor MPL 0.0025
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0025
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0025
4217 Telomerase reverse transcriptase TERT 0.0024
3957 Adenosine deaminase ADA 0.0023
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0023
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0023
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0023
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0023
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0022
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0022
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0022
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0022
1039 Histone deacetylase 9 HDAC9 0.0022
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0022
26 Vascular endothelial growth factor receptor 3 FLT4 0.0022
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0022
2155 Insulin-degrading enzyme IDE 0.0022
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.0021
260 Cytochrome P450 51 ERG11 0.0021
761 Cytochrome P450 51 ERG11 0.0021
3163 Cytochrome P450 51 cyp51 0.0021
1244 Low-density lipoprotein receptor-related protein 2 LRP2 0.0021
32 Vascular endothelial growth factor receptor 1 FLT1 0.0021
871 Glucocorticoid receptor NR3C1 0.0021
2461 D-alanyl-D-alanine carboxypeptidase Not Available 0.002
5756 D-alanyl-D-alanine carboxypeptidase dac 0.002
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.002
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.002
4228 Keratin, type II cytoskeletal 7 KRT7 0.002
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0019
357 Carbonic anhydrase 2 CA2 0.0019
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0019
284 DNA-directed RNA polymerase beta chain rpoB 0.0019
5773 DNA-directed RNA polymerase beta chain rpoB 0.0019
512 DNA-directed RNA polymerase alpha chain rpoA 0.0019
5772 DNA-directed RNA polymerase alpha chain rpoA 0.0019
2320 Thymidine kinase, cytosolic TK1 0.0018
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0018
122 P2Y purinoceptor 12 P2RY12 0.0018
6766 O-GlcNAcase BT_4395 BT_4395 0.0018
1648 Elastin ELN 0.0017
275 Arachidonate 5-lipoxygenase ALOX5 0.0017
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0017
407 Vascular endothelial growth factor receptor 2 KDR 0.0017
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0017
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0016
390 Adenosine A3 receptor ADORA3 0.0016
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0016
1243 Cathepsin D CTSD 0.0016
1010 Cytochrome P450 51A1 CYP51A1 0.0016
373 Transthyretin TTR 0.0016
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0016
427 Substance-P receptor TACR1 0.0016
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0016
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0016
921 Glutamate receptor 2 GRIA2 0.0015
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0015
70 Type-1 angiotensin II receptor AGTR1 0.0015
2499 Tubulin beta-2C chain TUBB2C 0.0015
3844 HLA class II histocompatibility antigen, DQ(6) alpha chain HLA-DQA2 0.0015
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0014
6102 Arylamine N-acetyltransferase 2 NAT2 0.0014
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0014
2091 Endoplasmin HSP90B1 0.0014
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0013
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0013
4311 tRNA TRDMT1 0.0012
4325 tRNA trmD 0.0012
4328 tRNA trmD 0.0012
3587 Gastrotropin FABP6 0.0012
518 Peroxidase/catalase T katG 0.0012
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0012
4238 50S ribosomal protein L4 rplD 0.0011
5578 50S ribosomal protein L4 rplD 0.0011
6173 50S ribosomal protein L4 rplD 0.0011
6219 50S ribosomal protein L4 rplD 0.0011
6043 Putative G-protein coupled receptor 44 GPR44 0.0011
563 Thyroid peroxidase TPO 0.0011
634 Squalene monooxygenase SQLE 0.001
7196 Squalene monooxygenase ERG1 0.001
239 Coagulation factor X F10 0.001
4237 50S ribosomal protein L22 rplV 0.001
1714 Mitogen-activated protein kinase 3 MAPK3 0.001
564 Cellular retinoic acid-binding protein 1 CRABP1 0.001
1192 Sulfotransferase 1A1 SULT1A1 0.001
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.001
859 Cellular retinoic acid-binding protein 2 CRABP2 0.001
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.001
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.001
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.001
823 Fibroblast growth factor receptor 2 FGFR2 0.001
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.001
780 Retinoic acid receptor RXR-gamma RXRG 0.0009
229 Retinoic acid receptor beta RARB 0.0009
730 Retinoic acid receptor alpha RARA 0.0009
3917 Methylenetetrahydrofolate reductase MTHFR 0.0009
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0009
365 Dihydrofolate reductase DHFR 0.0009
2381 Dihydrofolate reductase DFR1 0.0009
2833 Dihydrofolate reductase Not Available 0.0009
2931 Dihydrofolate reductase folA 0.0009
3544 Dihydrofolate reductase folA 0.0009
3682 Dihydrofolate reductase folA 0.0009
6642 Dihydrofolate reductase folA 0.0009
6756 Dihydrofolate reductase dfrA 0.0009
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0009
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0009
459 Retinoic acid receptor RXR-alpha RXRA 0.0008
88 Retinoic acid receptor RXR-beta RXRB 0.0008
2236 Casein kinase II subunit alpha CSNK2A1 0.0008
3830 Calreticulin CALR 0.0008
162 Retinoic acid receptor gamma-1 RARG 0.0008
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0008
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0008
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0008
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0008
6034 Hydroxyindole O-methyltransferase ASMT 0.0008
6035 Nuclear receptor ROR-beta RORB 0.0008
6036 Eosinophil peroxidase EPX 0.0008
811 Translocator protein TSPO 0.0008
3856 Fibroblast growth factor receptor 3 FGFR3 0.0008
400 Coagulation factor IX F9 0.0008
5461 Coagulation factor IX F9 0.0008
4103 Proteasome subunit beta type 2 PSMB2 0.0007
4102 Proteasome subunit beta type 5 PSMB5 0.0007
4101 Proteasome subunit beta type 1 PSMB1 0.0007
1063 Signal transducer and activator of transcription 5B STAT5B 0.0007
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0007
4226 Uridine phosphorylase 2 UPP2 0.0007
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0007
814 Ryanodine receptor 1 RYR1 0.0007
822 Aldose reductase AKR1B1 0.0007
4081 Vitamin K epoxide reductase complex subunit 1-like protein 1 VKORC1L1 0.0007
604 Vitamin K-dependent protein Z PROZ 0.0007
6228 Nuclear receptor coactivator 1 NCOA1 0.0007
6241 Nuclear receptor coactivator 2 NCOA2 0.0007
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0007
765 Indoleamine 2,3-dioxygenase IDO1 0.0007
251 Alcohol dehydrogenase 1A ADH1A 0.0007
4225 Uridine phosphorylase 1 UPP1 0.0007
705 Glutamate receptor 1 GRIA1 0.0007
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0007
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0006
820 Glycine receptor subunit alpha-2 GLRA2 0.0006
268 Adenosine A2b receptor ADORA2B 0.0006
1245 Vitamin K-dependent protein S PROS1 0.0006
413 Amidophosphoribosyltransferase PPAT 0.0006
2515 Amidophosphoribosyltransferase purF 0.0006
3714 Amidophosphoribosyltransferase purF 0.0006
422 Vitamin K-dependent protein C PROC 0.0006
537 ATP synthase delta chain, mitochondrial ATP5D 0.0006
936 Ephrin type-A receptor 2 EPHA2 0.0006
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0006
484 Tyrosine-protein kinase ABL2 ABL2 0.0006
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0006
444 Alcohol dehydrogenase 1B ADH1B 0.0006
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0006
448 Vitamin K-dependent gamma-carboxylase GGCX 0.0006
1275 Estrogen sulfotransferase SULT1E1 0.0005
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0005
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0005
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0005
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0005
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0005
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0005
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0005
3639 Thymidine phosphorylase deoA 0.0005
3936 Thymidine phosphorylase TYMP 0.0005
760 Fibroblast growth factor 1 FGF1 0.0005
517 Alcohol dehydrogenase 1C ADH1C 0.0005
798 Osteocalcin BGLAP 0.0005
5934 Cytochrome P450 26A1 CYP26A1 0.0005
1050 Bile salt sulfotransferase SULT2A1 0.0005
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0005
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0005
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0005
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0005
369 Coagulation factor VII F7 0.0005
3937 Fatty-acid amide hydrolase FAAH 0.0005
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0005
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0004
165 FL cytokine receptor FLT3 0.0004
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0004
24 Thymidylate synthase TMP1 0.0004
359 Thymidylate synthase TYMS 0.0004
2626 Thymidylate synthase thyA 0.0004
2729 Thymidylate synthase thyA 0.0004
5352 Thymidylate synthase THYA 0.0004
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0004
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0004
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0004
295 Carbonic anhydrase 1 CA1 0.0004
54 Prothrombin F2 0.0003
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