DT-Web

DB00841 - Dobutamine


Identification
Name Dobutamine
Accession Number DB00841 (APRD00122)
Type small molecule
Description A beta-2 agonist catecholamine that has cardiac stimulant action without evoking vasoconstriction or tachycardia. It is proposed as a cardiotonic after myocardial infarction or open heart surgery. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 301.3801
Groups approved
Monoisotopic Weight 301.167793607
Pharmacology
Indication For inotropic support in the short- term treatment of patients with cardiac decompensation due to depressed contractility resulting either from organic heart disease or from cardiac surgical procedures
Mechanism of action Dobutamine directly stimulates beta-1 receptors of the heart to increase myocardial contractility and stroke volume, resulting in increased cardiac output.
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination In human urine, the major excretion products are the conjugates of dobutamine and 3-O-methyl dobutamine.
Toxicity Not Available
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Amitriptyline The tricyclic antidepressant, amitriptyline, increases the sympathomimetic effect, dobutamine.
Amoxapine The tricyclic antidepressant, amoxapine, increases the sympathomimetic effect of dobutamine.
Clomipramine The tricyclic antidepressant, clomipramine, increases the sympathomimetic effect of dobutamine.
Desipramine The tricyclic antidepressant, desipramine, increases the sympathomimetic effect of dobutamine.
Doxepin The tricyclic antidepressant, doxepin, increases the sympathomimetic effect of dobutamine.
Entacapone Entacapone increases the effect and toxicity of the sympathomimetic, dobutamine.
Guanethidine Dobutamine may decrease the effect of guanethidine.
Imipramine The tricyclic antidepressant, imipramine, increases the sympathomimetic effect of dobutamine.
Isocarboxazid Increased arterial pressure
Linezolid Possible increase of arterial pressure
Methyldopa Increased arterial pressure
Midodrine Increased arterial pressure
Moclobemide Moclobemide increases the sympathomimetic effect of dobutamine.
Nortriptyline The tricyclic antidepressant, nortriptyline, increases the sympathomimetic effect of dobutamine.
Phenelzine Increased arterial pressure
Rasagiline Increased arterial pressure
Reserpine Increased arterial pressure
Food Interactions Not Available

Targets


Beta-1 adrenergic receptor
Name Beta-1 adrenergic receptor
Gene Name ADRB1
Pharmacological action yes
Actions agonist
References
  • Junker V, Becker A, Huhne R, Zembatov M, Ravati A, Culmsee C, Krieglstein J: Stimulation of beta-adrenoceptors activates astrocytes and provides neuroprotection. Eur J Pharmacol. 2002 Jun 20;446(1-3):25-36. - Pubmed
  • La Rosee K, Huntgeburth M, Rosenkranz S, Bohm M, Schnabel P: The Arg389Gly beta1-adrenoceptor gene polymorphism determines contractile response to catecholamines. Pharmacogenetics. 2004 Nov;14(11):711-6. - Pubmed
  • Bruck H, Leineweber K, Temme T, Weber M, Heusch G, Philipp T, Brodde OE: The Arg389Gly beta1-adrenoceptor polymorphism and catecholamine effects on plasma-renin activity. J Am Coll Cardiol. 2005 Dec 6;46(11):2111-5. Epub 2005 Nov 4. - Pubmed
  • Raddatz A, Kubulus D, Winning J, Bauer I, Pradarutti S, Wolf B, Kreuer S, Rensing H: Dobutamine improves liver function after hemorrhagic shock through induction of heme oxygenase-1. Am J Respir Crit Care Med. 2006 Jul 15;174(2):198-207. Epub 2006 Apr 20. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score 0.7054
Beta-2 adrenergic receptor
Name Beta-2 adrenergic receptor
Gene Name ADRB2
Pharmacological action unknown
Actions agonist
References
  • Tibayan FA, Chesnutt AN, Folkesson HG, Eandi J, Matthay MA: Dobutamine increases alveolar liquid clearance in ventilated rats by beta-2 receptor stimulation. Am J Respir Crit Care Med. 1997 Aug;156(2 Pt 1):438-44. - Pubmed
DTHybrid score 0.7112

Enzymes


Catechol O-methyltransferase
Name Catechol O-methyltransferase
Gene Name COMT
Actions substrate
References
  • -
  • Raxworthy MJ, Youde IR, Gulliver PA: Catechol-O-methyltransferase: substrate-specificity and stereoselectivity for beta-adrenoceptor agents. Xenobiotica. 1986 Jan;16(1):47-52. - Pubmed
  • Yan M, Webster LT Jr, Blumer JL: Kinetic interactions of dopamine and dobutamine with human catechol-O-methyltransferase and monoamine oxidase in vitro. J Pharmacol Exp Ther. 2002 Apr;301(1):315-21. - Pubmed
  • Yan M, Webster LT Jr, Blumer JL: Kinetic interactions of dopamine and dobutamine with human catechol-O-methyltransferase and monoamine oxidase in vitro. J Pharmacol Exp Ther. 2002 Apr;301(1):315-21. - Pubmed
DTHybrid score 0.7947

Predictions


Id Partner name Gene Name Score
1517 Beta-3 adrenergic receptor ADRB3 0.1348
4119 Cytochrome P450 2D6 CYP2D6 0.1101
556 Alpha-1A adrenergic receptor ADRA1A 0.0576
1588 Multidrug resistance protein 1 ABCB1 0.0545
318 Alpha-2A adrenergic receptor ADRA2A 0.0534
5455 Arylsulfatase A ARSA 0.0518
320 5-hydroxytryptamine 1A receptor HTR1A 0.0509
4512 Cytochrome P450 3A4 CYP3A4 0.0397
3941 Amine oxidase [flavin-containing] A MAOA 0.0395
4757 Cytochrome P450 2C9 CYP2C9 0.0374
6144 Solute carrier family 22 member 2 SLC22A2 0.0354
4200 Cytochrome P450 1A2 CYP1A2 0.0342
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0326
3939 Amine oxidase [flavin-containing] B MAOB 0.0295
885 5-hydroxytryptamine 1B receptor HTR1B 0.0284
3923 Cholinesterase BCHE 0.028
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0267
6016 Cytochrome P450 2C19 CYP2C19 0.0265
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0262
2300 Lysozyme E 0.0243
3633 Lysozyme R 0.0243
5597 Lysozyme 17 0.0243
632 Alpha-1B adrenergic receptor ADRA1B 0.022
629 Alpha-2B adrenergic receptor ADRA2B 0.022
6145 Solute carrier family 22 member 1 SLC22A1 0.0212
146 Androgen receptor AR 0.021
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0186
6024 Cytochrome P450 1A1 CYP1A1 0.0184
378 Alpha-2C adrenergic receptor ADRA2C 0.0184
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0181
1181 Alpha-1-acid glycoprotein 1 ORM1 0.018
1820 Beta-nerve growth factor NGF 0.0166
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.016
4146 Phosphatidylinositol 3-kinase regulatory subunit gamma PIK3R3 0.0151
4145 Phosphatidylinositol 3-kinase regulatory subunit beta PIK3R2 0.0151
330 Spermidine synthase SRM 0.0149
3038 Spermidine synthase speE 0.0149
828 Phenylalanine-4-hydroxylase PAH 0.0149
3109 Phenylalanine-4-hydroxylase phhA 0.0149
5718 Cytochrome P450 2A6 CYP2A6 0.0143
713 Sodium-dependent dopamine transporter SLC6A3 0.0139
789 Alpha-1D adrenergic receptor ADRA1D 0.0131
6013 Cytochrome P450 2E1 CYP2E1 0.0131
113 S-adenosylmethionine decarboxylase proenzyme AMD1 0.0128
453 S-adenosylmethionine synthetase isoform type-1 MAT1A 0.0126
334 S-adenosylmethionine synthetase isoform type-2 MAT2A 0.0126
1281 Phosphatidylinositol 3-kinase regulatory subunit alpha PIK3R1 0.0125
4292 Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase lpxA 0.0124
411 Glycine N-methyltransferase GNMT 0.0122
3076 Antigen 85-C fbpC 0.0122
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0122
824 Sodium-dependent serotonin transporter SLC6A4 0.0118
358 Cystathionine beta-synthase CBS 0.0117
777 Tumor necrosis factor TNF 0.0112
6147 Solute carrier family 22 member 3 SLC22A3 0.0109
118 Organic cation/carnitine transporter 2 SLC22A5 0.0107
23 D(1A) dopamine receptor DRD1 0.0094
6847 Lactase-phlorizin hydrolase LCT 0.0093
4924 Cytochrome P450 2C8 CYP2C8 0.0083
1176 Mitogen-activated protein kinase 1 MAPK1 0.0083
6107 Cytochrome P450 3A7 CYP3A7 0.008
4118 Cytochrome P450 3A5 CYP3A5 0.0076
3809 Estrogen-related receptor gamma ESRRG 0.0072
136 Estrogen receptor ESR1 0.0069
1374 Natriuretic peptides B NPPB 0.0061
1827 Gap junction alpha-1 protein GJA1 0.0061
1908 Vascular cell adhesion protein 1 VCAM1 0.0061
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.006
432 D(4) dopamine receptor DRD4 0.0059
131 Synaptic vesicular amine transporter SLC18A2 0.0058
638 D(3) dopamine receptor DRD3 0.0057
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0055
869 Estrogen receptor beta ESR2 0.0054
373 Transthyretin TTR 0.0051
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.005
831 D(2) dopamine receptor DRD2 0.0048
153 Dopamine beta-hydroxylase DBH 0.0047
3811 Cytochrome P450 19A1 CYP19A1 0.0045
183 Vascular endothelial growth factor A VEGFA 0.0045
6151 Monocarboxylate transporter 10 SLC16A10 0.004
6149 Solute carrier family 22 member 10 SLC22A10 0.004
6167 Organic solute transporter subunit beta OSTB 0.0037
6166 Organic solute transporter subunit alpha OSTA 0.0037
1360 Sphingomyelin phosphodiesterase SMPD1 0.0036
163 D(1B) dopamine receptor DRD5 0.0036
502 5-hydroxytryptamine 2A receptor HTR2A 0.0036
492 Histamine H1 receptor HRH1 0.0035
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0034
3947 Xanthine dehydrogenase/oxidase XDH 0.0032
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0031
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0031
1256 5-hydroxytryptamine 6 receptor HTR6 0.003
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0029
6141 Sodium/bile acid cotransporter SLC10A1 0.0029
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0028
124 Histamine H2 receptor HRH2 0.0028
465 Calmodulin CALM1 0.0028
716 5-hydroxytryptamine 7 receptor HTR7 0.0028
6432 Transporter snf 0.0027
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0027
436 5-hydroxytryptamine 2B receptor HTR2B 0.0026
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0025
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0025
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0025
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0025
20 Prostaglandin G/H synthase 1 PTGS1 0.0024
1024 Solute carrier family 22 member 11 SLC22A11 0.0024
233 Potassium channel subfamily K member 2 KCNK2 0.0023
2164 Multidrug resistance-associated protein 4 ABCC4 0.0023
590 5-hydroxytryptamine 2C receptor HTR2C 0.0023
862 Multidrug resistance-associated protein 1 ABCC1 0.0022
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0022
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0022
6142 Solute carrier family 22 member 8 SLC22A8 0.0021
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.002
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0019
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0019
6106 Cytochrome P450 2C18 CYP2C18 0.0019
1729 Solute carrier family 22 member 6 SLC22A6 0.0019
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0019
833 Organic cation/carnitine transporter 1 SLC22A4 0.0019
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0018
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0018
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0017
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0017
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0016
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0016
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0015
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0015
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0015
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0015
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0014
6030 Cytochrome P450 2B6 CYP2B6 0.0014
587 Serum albumin ALB 0.0009
↑